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**Title:** McCance & Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition
**Authors:** Kathryn L. McCance, Sue E. Huether, Valentina L. Brashers, Neal S. Rote
**Overview:**
"McCance & Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition" is a comprehensive textbook that provides an in-depth understanding of the mechanisms of disease and their manifestations in both adults and children. This edition continues to emphasize the biological and pathophysiological processes underlying diseases, integrating clinical implications and diagnostic considerations to prepare students for clinical practice. It is designed for students and practitioners in nursing, medicine, and allied health fields, offering a thorough grounding in the principles of pathophysiology and the latest research findings in the field.
**Structure and Content:**
1. **Unit I: The Cell:**
- **Chapter 1: Cellular Biology:** Overview of cell structure and function, including cell communication, energy production, and cell cycle.
- **Chapter 2: Altered Cellular and Tissue Biology:** Cellular adaptation, injury, and death, including mechanisms of cellular injury and repair.
- **Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids and Bases:** Fluid and electrolyte balance, acid-base homeostasis, and the role of buffers.
2. **Unit II: Genes and Genetic Diseases:**
- **Chapter 4: Genes and Genetic Diseases:** Genetic principles, patterns of inheritance, and the molecular basis of genetic diseases.
- **Chapter 5: Genes, Environment, and Common Diseases:** Interaction between genetic predisposition and environmental factors in disease development.
3. **Unit III: Mechanisms of Self-Defense:**
- **Chapter 6: Innate Immunity: Inflammation and Wound Healing:** Components and functions of
innate immunity, inflammation, and the healing process.
- **Chapter 7: Adaptive Immunity:** Development and function of adaptive immunity, including B and T lymphocytes.
- **Chapter 8: Alterations in Immunity and Inflammation:** Disorders of the immune system, including hypersensitivity, autoimmunity, and immunodeficiency.
- **Chapter 9: Infection:** Mechanisms of infection, host defense mechanisms, and the pathophysiology of infectious diseases.
4. **Unit IV: Cellular Proliferation and Cancer:**
- **Chapter 10: Biology of Cancer:** Cellular and molecular basis of cancer, including oncogenes, tumor suppressor genes, and the hallmarks of cancer.
- **Chapter 11: Cancer Epidemiology:** Risk factors, prevention, and screening for cancer.
- **Chapter 12: Cancer in Children:** Pediatric oncology, including common childhood cancers and their treatment.
5. **Unit V: The Neurologic System:**
- **Chapter 13: Structure and Function of the Neurologic System:** Anatomy and physiology of the nervous system.
- **Chapter 14: Pain, Temperature, Sleep, and Sensory Function:** Pathophysiology of pain, temperature regulation, sleep disorders, and sensory impairments.
- **Chapter 15: Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction:** Neurologic disorders, including stroke, epilepsy, multiple sclerosis, and neurodegenerative diseases.
- **Chapter 16: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders:** Pathophysiology of psychiatric disorders, including schizophrenia, depression, and anxiety.
6. **Unit VI: The Endocrine System:**
- **Chapter 17: Mechanisms of Hormonal Regulation:** Overview of endocrine system function and hormonal regulation.
- **Chapter 18: Alterations of Hormonal Regulation:** Disorders of the endocrine system, including diabetes, thyroid disorders, and adrenal dysfunction.
7. **Unit VII: The Hematologic System:**
- **Chapter 19: Structure and Function of the Hematologic System:** Anatomy and physiology of blood and the hematopoietic system.
- **Chapter 20: Alterations of Hematologic Function:** Hematologic disorders, including anemias, leukemias, lymphomas, and coagulopathies.
8. **Unit VIII: The Cardiovascular and Lymphatic Systems:**
- **Chapter 21: Structure and Function of the Cardiovascular and Lymphatic Systems:** Anatomy and physiology of the heart, blood vessels, and lymphatic system.
- **Chapter 22: Alterations of Cardiovascular Function:** Cardiovascular diseases, including hypertension, coronary artery disease, heart failure, and congenital heart defects.
- **Chapter 23: Alterations of Hematologic Function in Children:** Pediatric hematologic disorders.
9. **Unit IX: The Pulmonary System:**
- **Chapter 24: Structure and Function of the Pulmonary System:** Anatomy and physiology of the respiratory system.
- **Chapter 25: Alterations of Pulmonary Function:** Respiratory disorders, including chronic obstructive pulmonary disease (COPD), asthma, pneumonia, and pulmonary hypertension.
- **Chapter 26: Alterations of Pulmonary Function in Children:** Pediatric respiratory disorders.
10. **Unit X: The Renal and Urologic Systems:**
- **Chapter 27: Structure and Function of the Renal and Urologic Systems:** Anatomy and physiology of the kidneys and urinary system.
- **Chapter 28: Alterations of Renal and Urinary Tract Function:** Renal and urinary disorders, including acute kidney injury, chronic kidney disease, and urinary tract infections.
- **Chapter 29: Alterations of Renal and Urinary Tract Function in Children:** Pediatric renal and urinary disorders.
11. **Unit XI: The Digestive System:**
- **Chapter 30: Structure and Function of the Digestive System:** Anatomy and physiology of the gastrointestinal tract and accessory organs.
- **Chapter 31: Alterations of Digestive Function:** Gastrointestinal disorders, including inflammatory bowel disease (IBD), liver disease, and pancreatitis.
- **Chapter 32: Alterations of Digestive Function in Children:** Pediatric gastrointestinal disorders.
12. **Unit XII: The Reproductive Systems:**
- **Chapter 33: Structure and Function of the Reproductive Systems:** Anatomy and physiology of the male and female reproductive systems.
- **Chapter 34: Alterations of the Female Reproductive System:** Disorders of the female reproductive system, including polycystic ovary syndrome (PCOS), endometriosis, and breast cancer.
- **Chapter 35: Alterations of the Male Reproductive System:** Disorders of the male reproductive system, including prostate cancer, erectile dysfunction, and testicular disorders.
- **Chapter 36: Sexually Transmitted Infections:** Pathophysiology of common sexually transmitted infections (STIs).
13. **Unit XIII: The Integumentary System:**
- **Chapter 37: Structure and Function of the Integumentary System:** Anatomy and physiology of the skin and associated structures.
- **Chapter 38: Alterations of the Integument in Children:** Pediatric dermatologic disorders.
- **Chapter 39: Alterations of the Integument in Adults:** Dermatologic disorders, including skin infections, inflammatory skin conditions, and skin cancer.
14. **Unit XIV: The Musculoskeletal System:**
- **Chapter 40: Structure and Function of the Musculoskeletal System:** Anatomy and physiology of bones, muscles, and joints.
- **Chapter 41: Alterations of Musculoskeletal Function:** Musculoskeletal disorders, including osteoporosis, arthritis, and muscular dystrophies.
- **Chapter 42: Alterations of Musculoskeletal Function in Children:** Pediatric musculoskeletal disorders.
**Features:**
- **Detailed Pathophysiology:** Comprehensive coverage of the mechanisms of disease, from the cellular level to system-wide processes.
- **Clinical Correlations:** Integration of clinical scenarios and case studies to illustrate the application of pathophysiological concepts in practice.
- **Visual Aids:** Numerous tables, figures, and illustrations to enhance understanding of complex concepts and processes.
- **Summary and Review:** Each chapter includes summaries and review questions to reinforce learning and assess comprehension.
- **Current Research:** Incorporation of the latest research findings and clinical guidelines to ensure upto-date content.
**Audience:**
"McCance & Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition" is intended for students and practitioners in nursing, medicine, and allied health fields. The textbook is suitable for both undergraduate and graduate-level courses in pathophysiology, as well as for professionals seeking a comprehensive reference on the subject. It is also a valuable resource for educators, providing a structured and detailed curriculum for teaching pathophysiology.
**Conclusion:**
"McCance & Huether’s Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition" by Kathryn L. McCance, Sue E. Huether, Valentina L. Brashers, and Neal S. Rote is a cornerstone resource for understanding the complex mechanisms of disease. The textbook’s thorough and detailed approach to pathophysiology, combined with its clinical correlations and visual aids, makes it an indispensable tool for students and professionals in
the health sciences. Through its comprehensive coverage and clear explanations, this edition provides a solid foundation for the study and practice of pathophysiology.