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MedicationsAddressesincreasingcomplexityof Typeandtypediabetes:earlymeticulousglucosecontrolappearstopreventCVDmanyyearslater(“metabolic memory”and“legacyeffect”)“TheADArecommendsthata PMIDTreatmentapproachtotypediabetes:Past,presentandfuture.Preventionoftypediabetes Preventionoftypediabeteswillbringsubstantialbenefitstothepatient,whootherwisecouldentermanyadesofdrugtherapyandcomplicationsMetabolic surgeryDiabetesmellitus(DM)ischronic,lifelongprogressivemetabolicdiseasecharacterizedbyhyperglycaemiaduetoabsoluteorrelativeinsulinopaeniaFocus ontreatmentsforglycemiccontrolMichaelANauck,JakobWefers,JurisJMeierBehavioralapproachesAuthor pharmacologicaltreatmentsusedin Typediabeteshasexpanded·Treatmentoftypediabetes:challenges,hopes,andanticipatedsuccessesKristinaBlaslov,FranStjepanNaranđa,IvanKruljac,and IvanaPavlićRenarThereareseveraldifferenttypesofDMandeacharecausedbyacomplexinterplaybetweengeneticpredispositionandenvironmentalfactors SeveraldrugsincludedinNGhavenowbeenexploredincardiovascularoutcometrials(CVOTs); Typeusedtobecalledothernames(“juvenilediabetes”, “insulin-dependentdiabetes”).Considerableevidencesuggestthattypediabetescanbepreventedbymanagingobesityandimpairedglucoseregulationwith Choicesforthetreatmentoftypediabetesmellitus(T2DM)havemultipliedasourunderstandingoftheunderlyingpathophysiologicdefectshasevolvedTreatment shouldFoundationaltherapyismetforminandcomprehensivelifestylemanagement(includingweightmanagementandphysicalactivity)Metforministhepreferred initialglucoseloweringmedicationformostpeoplewithT2DThisrecommendationisbasedontheefficacy,safety,tolerability,andextensiveclinical•Typeand typediabetes:earlymeticulousglucosecontrolappearstopreventCVDmanyyearslater(“metabolicmemory”and“legacyeffect”)“TheADArecommendsthata reasonableA1CgoalformanynonpregnantadultswithtypediabetesislessthanpercentbasedontheavailableevidencetodateThisalgorithmformanagementof personswithtypediabetesincludesdistinctsections:(1)PrinciplesfortheManagementofTypeDiabetes;(2)Complications-CentricModelfortheCareofPersons withOverweight/Obesity;(3)PrediabetesAlgorithm;(4)AtheroscleroticCardiovascularDiseaseRiskReductionAlgorithm:Dyslipidemia;(5)Ather INTRODUCTIONIntype1,thepancreasdoesnotmakeinsulinDespitethesuccessfuldevelopmentofnew ImprovingGlycemicManagementItusually startsasachildorteen optimiseandpersonalisetreatments