Role of In Vitro Release Testing in Drug Development IVRT (In Vitro Release Testing) plays an indispensable role when it comes to analyzing the release performance and also drug test diffusion. It works effectively in saving both cost and time, especially when compared to those of traditional bioequivalence studies. The said testing method also has a crucial role in ensuring both consistency and also quality in the manufacturing process. Being a highly result-oriented research and development method, IVRT is useful in developing and optimizing formulations while letting you provide complete quality control too. It helps in monitoring the production quality with time. As a result-oriented method, IVRT also determines the rate of drug release. Besides, the process also works when it comes to choosing a clinical candidate with QbD (Quality by Design) principles. Besides, it's also effective in serving as a cost-effective method for analyzing products.
What is the Theory and Principle of IVRT? A proper IVRT method is related to mimicking skin permeation kinetics such as membrane, donor, and a complete receptor medium, which is determined for drug concentration. Besides, drug release from various semisolid dosage forms generally follows a simple equation of Higuchi. The equation is: Q = 2C0 • (Dt/n)1/2 One can use this equation mostly in the condition of the solubilized drug in the released drug and formation matrix. The drug quantity that is released during the experiment is directly proportional to the square root of time.
Tergus Provides FDA-approved IVRT Test Tergus is the most sought-after name that houses the largest inventory of 120+ vertical Franz diffusion cells for supporting world-class IVRT studies. The company works with highly specialized protocols for testing for matching the specific requirements of clients with several challenging APIs. It is blessed with a dynamic team in designing those discriminatory IVRT techniques.