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ARTFUL ENDING

CONFOCAL FLUORESCENCE MICROGRAPH: JEREMY G.T. WURTZEL AND LAWRENCE GOLDFINGER, PHD

Break Out the Bubbly A living fibroblast cell—at 630x magnification—effervescent with activity. The red bubbles are coated with Ras proteins, which stimulate growth. Ras proteins traffic through the cell’s vesicle membranes (blue), which bud off the Golgi of the cell (green). In normal growth, Ras proteins travel from the Golgi to the outer plasma membrane. Uncontrolled cell growth— and tumor formation—may be linked to abnormal patterns of Ras movement. “Location and direction mean everything,” says Assistant Professor Lawrence E. Goldfinger, PhD, who studies Ras intracellular trafficking. “Elucidating the patterns might help us determine how to inhibit the hyperactive growth linked with cancer and other diseases,” he says. WINTER 2014 | TEMPLE HEALTH MAGAZINE |

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Profile for Temple Health

Temple Health - Temple Health Magazine - Winter 2014  

Winter 2014 Issue of Temple Health Magazine

Temple Health - Temple Health Magazine - Winter 2014  

Winter 2014 Issue of Temple Health Magazine