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Dentist’s Guide to Medical Conditions, Medications & Complications

K anchan G anda , M.D.

Dentist’sGuidetoMedical Conditions,Medications, andComplications

Dentist’sGuideto MedicalConditions, Medications,and Complications

SecondEdition

Thiseditionfirstpublished2013 C 2013byJohnWiley&Sons,Inc. Firsteditionpublished2008.

Wiley-BlackwellisanimprintofJohnWiley&Sons,formedbythemergerofWiley’sglobalScientific, TechnicalandMedicalbusinesswithBlackwellPublishing.

Editorialoffices: 2121StateAvenue,Ames,Iowa50014-8300,USA TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK 9600GarsingtonRoad,Oxford,OX42DQ,UK

Fordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapply forpermissiontoreusethecopyrightmaterialinthisbookpleaseseeourwebsiteat www.wiley.com/wiley-blackwell.

Authorizationtophotocopyitemsforinternalorpersonaluse,ortheinternalorpersonaluseofspecific clients,isgrantedbyBlackwellPublishing,providedthatthebasefeeispaiddirectlytotheCopyright ClearanceCenter,222RosewoodDrive,Danvers,MA01923.Forthoseorganizationsthathavebeen grantedaphotocopylicensebyCCC,aseparatesystemofpaymentshasbeenarranged.Thefeecodes forusersoftheTransactionalReportingServiceareISBN-13:978-1-1183-1389-3/2013.

Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedastrademarks.All brandnamesandproductnamesusedinthisbookaretradenames,servicemarks,trademarksor registeredtrademarksoftheirrespectiveowners.Thepublisherisnotassociatedwithanyproductor vendormentionedinthisbook.

LimitofLiability/DisclaimerofWarranty:Whilethepublisherandauthor(s)haveusedtheirbest effortsinpreparingthisbook,theymakenorepresentationsorwarrantieswithrespecttotheaccuracy orcompletenessofthecontentsofthisbookandspecificallydisclaimanyimpliedwarrantiesof merchantabilityorfitnessforaparticularpurpose.Itissoldontheunderstandingthatthepublisheris notengagedinrenderingprofessionalservicesandneitherthepublishernortheauthorshallbeliable fordamagesarisingherefrom.Ifprofessionaladviceorotherexpertassistanceisrequired,theservices ofacompetentprofessionalshouldbesought.

LibraryofCongressCataloging-in-PublicationData

Ganda,KanchanM.,author.

[Dentist’sguidetomedicalconditionsandcomplications]

Dentist’sguidetomedicalconditions,medications,andcomplications/ KanchanM.Ganda.–Secondedition.

p.;cm.

Revisededitionof:Dentist’sguidetomedicalconditionsandcomplications/ KanchanM.Ganda.2008.

Includesbibliographicalreferencesandindex. ISBN978-1-118-31389-3(softback:alk.paper)–ISBN978-1-118-31390-9(epdf)–ISBN978-1-118-31391-6(epub)–ISBN978-1-118-31392-3(emobi)

I.Title.

[DNLM:1.StomatognathicDiseases–complications.2.DentalCareforChronicallyIll. 3.MedicalHistoryTaking.4.PharmaceuticalPreparations,Dental–administration&dosage. 5.PharmaceuticalPreparations,Dental–contraindications.6.StomatognathicDiseases–drug therapy.WU140]

RK55.S53

617.6 026–dc23

2013003815

AcataloguerecordforthisbookisavailablefromtheBritishLibrary. Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmay notbeavailableinelectronicbooks.

Coverimage: C webphotographeer CoverdesignbyMaggieVoss

Setin9.5/12ptPalatinobyAptara R Inc.,NewDelhi,India

12013

Dedication

Thisbookisdedicatedtoallmystudents,pastandpresent;tomylateparents,Amrit DeviandRoopKrishanDewan;andtomyfamily,foralltheirencouragementandlovingsupport.

Acknowledgmentsxii Introduction:IntegrationofMedicineinDentistryxiv

SectionI:PatientAssessment1

1.RoutineHistory-TakingandPhysicalExamination3

2.HistoryandPhysicalAssessmentoftheMedicallyComplex DentalPatient24

SectionII:Pharmacology33

3.EssentialsinPharmacology:DrugMetabolism,CytochromeP450 EnzymeSystem,andPrescriptionWriting35

4.LocalAnestheticsCommonlyUsedinDentistry:Assessment, Analysis,andAssociatedDentalManagementGuidelines54

5.PainPhysiology,Analgesics,OpioidDependencyMaintenance Therapies,MultimodalAnalgesia,andPainManagement Algorithms67

6.OdontogenicInfections,Antibiotics,andInfectionManagement Protocols110

7.AntifungalsCommonlyUsedinDentistry:Assessment,Analysis, andAssociatedDentalManagementGuidelines150

8.AntiviralsCommonlyUsedinDentistry:Assessment,Analysis, andAssociatedDentalManagementGuidelines155

SectionIII:AcuteCareandStressManagement159

9.ManagementofMedicalEmergencies:Assessment,Analysis,and AssociatedDentalManagementGuidelines161

10.OralandParenteralConsciousSedationforDentistry:Assessment, Analysis,andAssociatedDentalManagementGuidelines183

SectionIV:HematopoieticSystem199

11.CompleteBloodCount:Assessment,Analysis,andAssociated DentalManagementGuidelines201

12.RedBloodCellsAssociatedDisorder:Anemia:Assessment, Analysis,andAssociatedDentalManagementGuidelines209

13.RedBloodCellsAssociatedDisorder:Polycythemia:Assessment, Analysis,andAssociatedDentalManagementGuidelines222

14.RedBloodCellsAssociatedDisorder:Hemochromatosis: Assessment,Analysis,andAssociatedDentalManagement Guidelines225

SectionV:HemostasisandAssociatedBleedingDisorders229

15.PrimaryandSecondaryHemostasis:NormalMechanisms,Disease States,andCoagulationTests:Assessment,Analysis,and AssociatedDentalManagementGuidelines231

16.PlateletDisorders:Thrombocytopenia,PlateletDysfunction,and Thrombocytosis:Assessment,Analysis,andAssociatedDental ManagementGuidelines243

17.VonWillebrand’sDisease:Assessment,Analysis,andAssociated DentalManagementGuidelines250

18.CoagulationDisorders:CommonClottingFactorDeficiency DiseaseStates,AssociatedSystemicand/orLocalHemostasis Adjuncts,andDentalManagementGuidelines254

19.Anticoagulants:Assessment,Analysis,andAssociatedDental ManagementGuidelines262

SectionVI:CardiologyandRenalDisease273

20.RheumaticFever:Assessment,Analysis,andAssociatedDental ManagementGuidelines275

21.InfectiveEndocarditisandCurrentPremedicationProphylaxis Guidelines279

22.HypertensionandTargetOrganDiseaseStates:Assessment, Analysis,andAssociatedDentalManagementGuidelines288

23.CerebralCirculationDiseasesTIAsandCVAs:Assessment, Analysis,andAssociatedDentalManagementGuidelines300

24.CoronaryCirculationDiseases,ClassicAngina,andMyocardial Infarction:Assessment,Analysis,andAssociatedDental ManagementGuidelines302

25.CongestiveHeartFailure:Assessment,Analysis,andAssociated DentalManagementGuidelines311

26.CardiacArrhythmias:Assessment,Analysis,andAssociated DentalManagementGuidelines315

27.PeripheralCirculationDisease318

28.RenalFunctionTests,RenalDisease,andDialysis:Assessment, Analysis,andAssociatedDentalManagementGuidelines319

SectionVII:PulmonaryDiseases331

29.PulmonaryFunctionTestsandSedationwithPulmonaryDiseases: Assessment,Analysis,andAssociatedDentalManagement Guidelines333

30.UpperAirwayDisease:AllergicRhinitis,Sinusitis,and StreptococcalPharyngitis:Assessment,Analysis,andAssociated DentalManagementGuidelines337

31.AsthmaandAirwayEmergencies:Assessment,Analysis,and AssociatedDentalManagementGuidelines341

32.ChronicBronchitisandSmokingCessation348

33.Emphysema:Assessment,Analysis,andAssociatedDental ManagementGuidelines356

34.ChronicObstructivePulmonaryDisease:Assessment,Analysis, andAssociatedDentalManagementGuidelines358

35.ObstructiveSleepApnea:Assessment,Analysis,andAssociated DentalManagementGuidelines365

36.Tuberculosis:Assessment,Analysis,andAssociatedDental ManagementGuidelines367

SectionVIII:ClinicalPharmacology375

37.PrescribedandNonprescribedMedications:Assessment,Analysis, andAssociatedDentalManagementGuidelines377

SectionIX:Endocrinology383

38.IntroductiontoEndocrinologyandDiabetes:Assessment, Analysis,andAssociatedDentalManagementGuidelines385

39.ThyroidGlandDysfunctions:Assessment,Analysis,and AssociatedDentalManagementGuidelines403

40.AdrenalGlandDiseaseStates:Assessment,Analysis,and AssociatedDentalManagementGuidelines408

41.ParathyroidDysfunctionDiseaseStates:Assessment,Analysis, andAssociatedDentalManagementGuidelines417

42.GrowthHormoneDysfunctionandEndocrineTissuesofthe ReproductiveSystem433

SectionX:SeizureDisorders437

43.ClassicSeizures:Assessment,Analysis,andAssociatedDental ManagementGuidelines439

SectionXI:GastrointestinalConditionsandDiseases447

44.GastrointestinalDiseaseStatesandAssociatedOralCavity Lesions:Assessment,Analysis,andAssociatedDental ManagementGuidelines449

SectionXII:Hepatology465

45.LiverFunctionTests,Hepatitis,andCirrhosis:Assessment, Analysis,andAssociatedDentalManagementGuidelines467

SectionXIII:PostexposurePreventionandProphylaxis493

46.Needle-StickExposureProtocolandCDCRecommendationsfor DentalHealth-CareProvidersInfectedwiththeHepatitisBVirus495

SectionXIV:InfectiousDiseases503

47.HumanImmunodeficiencyVirus,HerpesSimplexandZoster, LymeDisease,MRSAInfection,andSexuallyTransmittedDiseases505

SectionXV:OralLesionsandDentistry539

48.TherapeuticManagementofOralLesionsinthe Immune-CompetentandtheImmune-CompromisedPatientinthe DentalSetting541

SectionXVI:TheFemalePatient:Pregnancy,Lactation,and Contraception565

49.Pregnancy,Lactation,andContraception:Assessmentand AssociatedDentalManagementGuidelines567

SectionXVII:Rheumatology:DiseasesoftheJoints,Bones, andMuscles587

50.ClassicRheumaticDiseases:AssessmentandAssociatedDental ManagementGuidelines589

SectionXVIII:Oncology:HeadandNeckCancers,Leukemias, Lymphomas,andMultipleMyeloma625

51.HeadandNeckCancersandAssociatedDentalManagement Guidelines627

SectionXIX:Psychiatry661

52.PsychiatricConditions:AssessmentofDiseaseStatesand AssociatedDentalManagementGuidelines663

SectionXX:Transplants683

53.OrganTransplants,ImmunosuppressiveDrugs,andAssociated DentalManagementGuidelines685

SectionXXI:CommonLaboratoryTests695

54ComprehensiveMetabolicPanelandCommonHematological Tests697

Appendix:SuggestedReading699 Index743

Acknowledgments

IwishtosincerelythankBruceJ.Baum,D.M.D.,Ph.D.,ChiefoftheGeneTherapy andTherapeuticsBranchattheNationalInstituteofDentalandCraniofacialResearch inBethesda,Maryland.Hewasinstrumentalinmentoringmeandmotivatingmeto publishmywork,whichisnowinitssecondedition.Dr.Baum’svisionfordentistry andhisconfidencethatmyworkwouldmakeadifferencehasbeenandcontinuesto beveryhumbling.

ThankstomyformerdeansatTuftsUniversitySchoolofDentalMedicine—Lonnie Norris,D.M.D,M.P.H.,andDeanofCurriculum,NancyArbree,D.D.S.,M.S.—formakingmyvisionofintegratingmedicineintothedentalcurriculumareality.Iwasgiven theflexibilitytocreateamedicinecurriculumforourstudentsandintegratethiseducationthroughallthefouryearsofdentalcurriculum.

MyverysincerethankstoHuwF.Thomas,B.D.S.,M.S.,Ph.D.,ourcurrentdeanatTuftsUniversitySchoolofDentalMedicine,andtoMarkNehring, M.Ed.,D.M.D.,M.P.H.,thechairoftheDepartmentofPublicHealthandCommunityServicesatTuftsUniversitySchoolofDentalMedicine(myformerchair), fortheirtremendoussupportinensuringarapidlyprocessedsabbatical,soI couldcompletethesecondeditionofmybook.Additionally,IamverygratefultomycolleaguesDianaEsshaki,D.M.D.,M.S.,andPatrickMcGarry,D.M.D., fortheirunconditionalsupportinefficientlyexecutingallresponsibilitieswhileI wasaway.

Toallthepastandpresentmedicinecoursespeakersandrotationdirectors,specialistsintheirrespectivefieldsofmedicine,thisuniquedentaleducationwouldhave beenincompletewithoutyouractiveparticipation,dedication,andsupport.Iwishto acknowledgeandthankyouallforyoureffortsandendlesssupport.

IalsowouldliketothankmyD’14studentMs.JaskarenK.Randhawaforherunflaggingsupportandhelpwiththeproofingofthematerial.

I’dliketothankmydaughterKiran,forpatientlyprovidingmewitharound-theclocktechnicalsupport.Also,sincerethankstomydaughterAnjaliandmyhusband, Om,bothofwhomarephysicians,forenthusiasticallyparticipatinginournumerous discussionsduringwhichtheyofferedtheirinsightsaboutpatientcare.

Thisfinestqualitysecondeditionwouldnothavebeenpossiblewithouttheassistanceofmyverytalentedprojectmanager,Ms.ShikhaSharmaofAptara,Inc., xii

NewDelhi,India.Herprofessionalism,veryfriendlypersonality,expertise,attentionto detailmadeitaverypleasurableexperienceindeed;sheissomeonewhowentabove andbeyondeverystepoftheway.Iamdelightedtohavebeenlinkedwithsucha talentedandknowledgeableindividualandIamsoextremelysatisfiedwiththefinal productshecreated!

Lastbutnotleast,Iwishtothankallmystudents,whohavebeenmyconstantsource ofinspiration.Inevercouldhaveexperiencedthejoyofteachingwithouttheiractive participationandenduranceinthelearningofmedicine!

Introduction:Integrationof MedicineinDentistry

Dentalcaretodayholdsmanychallengesforthedentalpractitioner.Patientsareliving longer,oftenretainingtheirowndentition,haveoneormoremedicalconditions,and routinelytakeseveralmedications.

Alongwithexcellenceindentistry,thepracticingdentisthasthedualtaskofstaying updatedwiththecurrentconceptsofmedicineandpharmacology.Theyshouldrightfullybecalledthe“PhysicianoftheOralCavity.”

Theintegrationofmedicineinthedentalcurriculumhasbecomeanecessity,and thisintegrationmustbeginwiththefreshmanclass,sothestudentscangainmaximum benefitandthechancetogaincredibility.Theintegrationofmedicineisbestachieved whendoneinacase-basedorproblem-basedformatandcorrelatedwiththebasicsciences,pharmacology,generalpathology,oralpathology,anddentistry.Thereneedsto beatruecommitmentand constant reinforcementoftheintegrationin all thedidactic andclinicalcourses.

Theintegrationofmedicine,pharmacology,andmedicallycomplexpatientcareis bestachievedwhendoneinapyramidalprocess,throughthefouryearsofdentaleducation.

Thefoundationshouldinstillabasicknowledgeof:

1.Standardandmedicallycomplexpatienthistory-takingandphysicalexamination.

2.Symptomsandsignsofhighest-priorityillnesses,alongwiththecommonlaboratorytestsevaluatingthosediseasestates.

3.Anesthetics,analgesics,antibiotics,antivirals,andantifungalsusedindentistry.

4.Prescriptionwriting.

“Normal”patientassessment,whenstressedinthefirstyear,preparesstudentsto betterunderstandthechangespromptedbydiseasestatesduringthesecondyearof theireducation,whendidacticandclinicalknowledgeofhighest-priorityillnesses,associateddiagnosticlaboratorytests,andthevastpharmacopeiausedforthecareofthose diseasesisincluded.Case-basedscenariosshouldbeusedtosolidifythisinformation.

Theprogressivelearninguptotheendofthesecondyearpreparesthestudentto “care”forthepatient“onpaper.”Withthestartoftheclinicalyears,thestudentispreparedtoapplythisknowledgetoward“actual”patientcare,whichoccurstypicallyduringthethirdandfourthyearsofeducation.

Duringthethirdyear,thestudentshouldparticipateinmedicalandsurgicalclinical rotationsinahospitalizedsettingandcompleteaHospitalClerkshipProgramwhere thestudentisexposedtohead-and-neckcancercare,emergencymedicine,criticalcare, anesthesia,hematology,oncology,transplants,cardiothoracicsurgery,andsoon.This exposurewillwidenthestudent’sknowledge,broadenclinicalperception,andfurther enhancethelinkbetweenmedicineanddentistry.

Duringtheclinicalyears,thestudentsshouldcompletefaculty-reviewedmedical consultsfor all theirmedicallycompromisedpatients, prior todentistry.Thispatientby-patienthealthstatusreviewwillhelpcorrectlytranslatetheirdidacticpatient-care knowledgeintheclinicalsetting.

Thetextisacompilationofmaterialsneededfortheintegrationofmedicineindentistry.Itisabookalldentalstudents and dentalpractitionerswillappreciatebothasa readandchair-side.

Thistextprovidesinformationonepidemiology,physiology,pathophysiology,laboratorytestsevaluation,associatedpharmacology,dentalalerts,andsuggesteddeviationsintheuseofanesthetics,analgesics,antibiotics,antivirals,andantifungalsforeach diseasestatediscussed.

Thestudentwillgreatlybenefitfromthesectionsdetailinghistory-takingandphysicalexamination;highlyexpandedclinicalandappliedpharmacologyofdentalanesthetics,analgesics,antibiotics,antivirals,andantifungals;stressmanagement;andmanagementofmedicalemergenciesinthedentalsetting.

I PatientAssessment

GENERALOVERVIEW

PatientInterviewIntroduction

1

RoutineHistory-Takingand PhysicalExamination

Theprimaryjobofthedentalstudentstartingclinicalworkistolearntoconducta patientworkupthoroughlyandefficiently.Theheartofeverypatientworkupisaset patterndoneinasequentialorderofdatacollectionandanalysis.

PatientWorkupSequentialPattern

Thesequentialpatternofpatientworkupconsistsofthefollowing:

1.Historyandphysicalexamination.

2.Laboratorydatacollectionandanalysis.

3.Diagnosticandtherapeuticplanformulation.

Thefirststep,thepatientinterview,orthehistory,isprobablythesinglemostimportanttaskinthediagnosticpatientworkupbecauseofitsimportanceindiagnosisandin thedevelopmentofagooddoctor-patientrelationship.Theprovidershoulddemonstrateaprofessionalmannerthatwillputthepatientatease.Duringtheinterview, alwayslistencarefullytothepatient.Useinterrogationsparingly,oruseitlatertoaida communicatingpatient,ortorestricttherarepatientwhohasatendencytoramble!

PatientInterviewPracticalPoints

Keepyourappearanceneatandclean.Thiswillhelpgainyourpatient’strust.Always introduceyourselfwhenmeetingapatientandrefertothepatientas“Mr.JohnDoe” or“MissJaneDoe.”Donotusefirstnamesduringtheinitialencounter.Exchangeafew briefpleasantriesbecausemovingforward,thiswillhelpbothyouandthepatientfeel comfortableandateasewithoneanother.

Dentist’sGuidetoMedicalConditions,Medications,andComplications,SecondEdition.KanchanM.Ganda. C 2013JohnWiley&Sons,Inc.Published2013byJohnWiley&Sons,Inc.

Alwayshaveafriendlyandsincereinterestinyourpatient’sproblem(s).Alwaysbe courteous,respectful,andconfidentialandshowacontinuedinterestwhileyouarewith thepatient.

PhysicalExaminationPracticalPoints

Priortothestartofthephysicalexaminationletthepatientknowthatyouaregoingto takethepulseandbloodpressureandexaminetheheadandneckarea.Thisheads-up willenablethepatienttounderstandthatyouwillbetouchinghimorher.Yourattentive andrespectfulwayswillenhanceagooddoctor-patientrelationship.

Thephysicalexaminationisanartthatislearnedbyconstantrepetition.Thereare manystylesandmethodsforconductingthegeneralexamination,andeveryclinician willultimatelychooseoneexaminationsequencetogoby.Mostclinicians,however, preferthehead-to-footorder.Whenexamininganyareaofthebody,itisusuallybestto followanorderlysequenceofinspection,palpation,percussion,andauscultation.This sequentialroutineensuresthoroughness.

Thephysicalexaminationshouldalwaysbeconductedandassessedinthecontextof thepatient’sdentalandmedicalhistory.Therangeof“normal”variesfrompatientto patient.

Thestudentneedstobecomefamiliarwiththeuseofthestethoscopeandtheblood pressurecuff.Fumblingwithyourequipmentorthetechniqueduringpatientexaminationwillcauseyouembarrassment.Thestudentalsoneedstopracticethehead-andneckexamtechniquesoftenonfriendsorfamilymemberstogetagoodsenseofthe normal.

History-TakingandPhysicalExamination:BroadConclusions

Afterthehistoryandphysicalexaminationiscompleted,youshould,inmostcases,be abletoanswerthefollowingquestions:

Thediseasestatesthatexistinthepatientandwhetherthepatient’sproblemsare acuteorchronic.

Theorgansystemsthatmaybeinvolved.

Thedifferentialdiagnosisofthepatient’sproblems.

Thelaboratoryteststhatwillbeneededfortheevaluationofthediseasestates.

Confirmationorexclusionofadiagnosisand/orwhethertofollowthecourseofa diseasestate.

HISTORY-TAKINGDETAILS

Thepurposeofmedicalhistoryandphysicalexaminationistocollectinformationfrom thepatient,toexaminethepatient,andtounderstandthepatient’sproblems.Traditionalhistory-takinghasseveralparts,eachwithaspecificpurpose.Inordertoachieve maximumsuccess,themedicalhistorymustbeaccurate,concise,andsystematic.

Thefollowingisastandardoutlineinsequentialorderofthedifferentcomponents ofhistory-taking.Theintroductorymaterialsinthehealthhistoryconsistofcollecting severaltypesofinformationfromthepatient.

DataCollection

Thefollowinginformationisobtainedinallpatientstogainabasicunderstandingof thepatient:

Dateofthevisit:Recordnumber:

Name: (last)(first)(middle)

Homeaddress:Homephone:

Businessaddress:Businessphone:Cellphone:

Occupation:Dateofbirth:

Sex:M/F/Transgender/Other

Maritalstatus:S/M/D/W/Partnership

Height:

Weight:

Referredby:

ChiefComplaint

Thechiefcomplaintstatesinthepatient’sownwordsthereasonforthevisit,forexample,“Ihaveatoothache”or“Ineedarootcanal.”

PresentHistory

Presenthistorylists,inclear,chronologicalorder,thedetailsoftheproblemorproblems forwhichthepatientisseekingcare.Youwilldeterminebyinterrogationatimelineof thefollowing:

1.Whendidthepatient’sproblem(s)begin?

2.Wheredidtheproblem(s)begin?

3.Whatkindsofsymptomsdidthepatientexperience?

4.Hasthepatienthadanytreatmentfortheproblem(s)?

5.Hasthetreatmenthadanypositiveornegativeeffectonthepatient’scondition?

6.Hasthepatient’slifestylebeenaffectedbytheproblem(s)?

PastHistory

Thepasthistorygivesyouaninsightaboutthehealthstatusofthepatientuntilnow. Checkwiththepatientforthepresenceorabsenceofdiseasesbyelicitingthe symptoms andsigns associatedwiththediseasestates.Itisbesttoaccessthediseasestateswith thepatientin alphabetical ordertoensureyouaddresseachdiseasestateanddonot missanything.Useinterrogationtocheckforthefollowingdiseasestates:

Anemia

Determinethepresenceorabsenceofthenutritional,congenital,andacquiredorchronic disease-associatedanemias.

BleedingDisorders

Determinethepresenceorabsenceofthecongenitalandacquiredtypesofbleeding disorders.

CardiorespiratoryDisorders

Determinewhetherthepatienthasahistoryofangina,myocardialinfarction,transientischemicattacks(TIAs),cerebrovascularattacks(CVAs/strokes),hypertension, rheumaticheartdisease,asthma,tuberculosis,bronchitis,sinusitis,andchronicobstructivepulmonarydisease(COPD).

Drugs/Medications

Determinethepatient’scurrentmedications.Checkforprescribed,herbal,andoverthe-counter(OTC)medications.Determinewhetherthepatientiscurrentlyoncorticosteroidsorhasbeenonthem,bymouthorbyinjection,fortwoweeksorlongerwithinthe pasttwoyears.Checkifthepatienthasknownallergiestoanydrugs,suchasNSAIDS, aspirin,codeine,morphine,penicillin,sulphaantimicrobials,bisulfites,metabisulfites, orlocalanesthetics.

EndocrineDisorders

Checkfordiabetes,hyperthyroidism,hypothyroidism,parathyroiddisorders,andpituitaryandadrenaldisorders(Addison’sdiseaseorCushing’ssyndrome).

FitsorFaints

Checkforthepresenceofdifferentkindsofseizures:grandmalepilepsy,petitmal epilepsy,temporallobeorpsychomotorepilepsy,orlocalizedmotorseizures.

GastrointestinalDisorders

Checkfororalulcerations,esophagitis,gastritis,pepticulcerations,Crohn’sdisease, celiacdisease,ulcerativecolitis,diverticulitis,polyps,andhemorrhoids.

HospitalAdmissions

Determinethecauseorcausesforadmissionandalsocheckifthepatienthadanyhistoryofaccidentsorinjuries.Determinewhetherthepatientwasgivenanyanesthesia, eitherlocalorgeneral,duringthehospitaladmission.Furthermore,determinewhether therewereanycomplicationsduringthehospitaladmissionduetotheanesthesiaor duetothemedical/surgicalconditionforwhichthepatientwasadmitted.Determine whetherthepatientwasgivenabloodtransfusionduringhospitalization.

ImmunologicalDiseases

Checkforlupus,Sjogrenssyndrome,rheumatoidarthritis,andpolyarthritisnodosa.

InfectiousDiseases

Checkforinfectiousdiseasesofchildhood:measles,mumps,chickenpox,streptococcuspharyngitis,rheumaticfever,orscarletfever.Alsocheckforinfectiousdiseasesof adulthood:sexuallytransmitteddiseases(STDs),hepatitis,HIVinfection,MethicillinResistantStaphylococcusAureus(MRSA)infection,andinfectiousmononucleosis.

JaundiceorLiverDisease

Ifthepatientisjaundicedorhashadjaundice,determinethecause.Isitduetoviral hepatitis,alcoholichepatitis,orgallstones?Determinewhetherthereisanyhistoryof gallbladderdysfunction.Checkwhetherthereisanyindicationofimproperliverfunction.

KidneyDisorders

Determinewhetherthereisanyindicationofkidneydysfunction,renalstones,urinary tractinfections,renaldisease,renalfailure,orrenaltransplant.

LikelihoodofPregnancy

Determinethedateofthepatient’slastmenstrualperiod(LMP)andwhetherthepatient ispregnant.Alwaysletthepatientknowthatpriortodentalradiographs,youneedto knowifthepatientispregnant.Youneedtoalsoknowthepregnancystatus,asthere arecertainanesthetics,analgesics,andantibioticsthatarecontraindicatedduringpregnancy.

MusculoskeletalDisorders

Checkforosteoporosisandothercausesofimpairedbonemetabolism,Paget’sdisease,osteoarthritis,rheumatoidarthritis,psoriaticarthritis,gout,musculardystrophy, polymyositis,andmyastheniagravis.

NeurologicalDisorders

Checkforcranialnervedisorders,headaches,facialpains,migraine,multiplesclerosis,motorneurondisease,transientischemicattacks(TIAs),orcerebrovascularaccidents(CVAs)associatedneurologicaldeficits,Parkinson’sdisease,andperipheralneuropathies.

ObstetricandGynecologicalDisorders

Checkforconditionsordiseasesthatcanleadtospontaneousabortions,miscarriages, bleeding,oranemia.Alsocheckforanytumorsneedingchemotherapyorradiotherapy.

PsychiatricDisease

Checkforpersonalitydisorders,neuroses,anxiety,phobias,hysteria,psychoses,schizophrenia,dementia,Alzheimer’sdisease,andposttraumaticstressdisorder(PTSD).

RadiationTherapy

CheckforanyradiationtotheheadandneckregionandtheRADSorGyofradiation received.

SkinDisorders

Lichenplanus,phemphigus,herpessimplex,herpeszoster,eczema,unhealedskin lesions,andurticaria(itchingoftheskin)areconditionsthatshouldbecheckedfor.

Tetanus

Determinethepatient’simmunizationstatusfortetanus,hepatitis,influenza,andpneumonia.

Violence

Checkfordomesticviolence,intimatepartnerviolence(IPV),andelderorchildabuse.

Wounds

Determinethepatient’swound-healingcapacity.

PersonalHistory

Inthispartofthehistory,wetrytogetaninsightintothepatient’slifestyle,occupation, andhabits.Inthelifestylecomponent,anattemptismadetounderstandwhatconstitutesatypicaldayforthepatient.Whatdoesthepatientdoforrecreation,relaxation, andsoon?Whatisthepatient’sjoblike?Arethereanyjob-relatedtoxicexposures?Is thereanyhistoryofalcohol,coffee,orteaintake?Howmuchofthesedoesthepatient consume?Isthereanyhistoryofdiarrheaorvomiting?

Isthereanyhistoryofsmokingcigarettesorusing“recreational”drugssuchasmarijuana,cocaine,oramphetamines?Hasthepatienteverusedintravenous(IV)drugsor swappedneedles?Hasthepatientbeenexposedtoanyinfectiousdiseasesorsexually transmitteddiseases(STDs)?Doesthepatientuseanyherbalmedicationsorover-thecountermedications?

Doesthepatientusedietpills,birthcontrolpills,laxatives,analgesics(aspirin, acetaminophen,NSAIDS,andotherpainmedications),orcough/coldmedications?

FamilyHistory

Oncethepatient’smedicalhistoryhasbeencompleted,itisimportanttoassessthe healthstatusoftheimmediatefamilymembers.Determinewhethercertaincommon

diseasesruninthefamilyorifafamilialdiseasepatternexists.Determinetheageand healthofthepatient’sparents,siblings,andchildren.Ifanymemberisdeceased,the causeofdeathandageatdeathshouldalwaysbeestablished.

Presenceofdiseaseswithastronghereditarycomponentortendencyforfamilial clusteringshouldbedetermined.Thesediseasesarecoronaryarterydisease(CAD), heartdisease,diabetesmellitus(DM),hypertension(Htn),stroke(CVA),asthma,allergies,arthritis,anemia,cancer,kidneydisease,orpsychiatricillness.

ReviewofSystems:OverviewandComponents

Reviewofsystems(ROS)isafinalmethodicalinquirypriortophysicalexamination. Allorgansystemsnotdiscussedduringtheinterviewaresystematicallyreviewedhere. Itprovidesathoroughsearchforfurther,asyetunestablished,diseaseprocessesinthe patient.Ifthepatienthasfailedtomentioncertainsymptoms,theprocessofROShelps remindthepatient.Also,ifyouhaveunknowinglyomittedquestioningthepatient aboutcertainaspectsofhisorherhealth,nowisthetimetoincludetheseaspects.

ReviewofSystems:AssessmentComponents

Constitutional

Determinewhetherthereisanyhistoryofrecentweightchange,anorexia(lossof appetite),weakness,fatigue,fever,chills,insomnia,irritability,ornightsweats.

Skin

Isthereanyhistoryofallergicskinrashes,itchingoftheskin,unhealedlesions(probably duetodiabetes,poordiet,steroids,HIV/AIDS,ansoon)?Istherashacuteorchronic? Istherashunilateralorbilateral?Doesthepatienthaveanyhistoryofbruisingor bleeding?

Head

Isthereanyhistoryofheadachesorlossofconsciousness(LOC)?LOCmaybedueto cardiovascular,neurologic,ormetaboliccauses;oritmaybeduetoanxiety.

Isthereanyhistoryofseizures?Aretheseizuresgeneralized(withorwithoutlossof consciousness)orfocal?Arethereanymotormovements?Isthereanyhistoryofhead injury?

Eyes

Checkforacuityofvision,historyofglaucoma(cancauseeyepain),redness,irritation, halos(seeingawhiteringaroundalightsource),orblurredvision.Isthereanyirritation oftheeyesorexcessivetearing?Thesesymptomscouldalsobeallergy-associated.

Ears

Checkforrecentchangesinhearing,earpain,discharge,vertigo(dizziness),orringing intheears(tinnitus).

LymphGlands

Checkforlymphglandularenlargementintheneckorelsewhere.Arethenodestenderorpainless,oraretheyhotorcoldtotouch?Whendidthepatientfirstnoticeany changesinthenodes?Arethenodesfreelymobile,oraretheyanchoredtotheunderlyingtissues?

RespiratorySystem

Askifthereisanyhistoryoffrequentsinusinfection,postnasaldrip,nosebleed,sore throat,orshortnessofbreath(SOB)onexertion,oratrest.SOBcanbeduetorespiratory, cardiac,ormetabolicdiseases.

Checkforwheezing(maybeduetoasthma,allergies,andsoon)andhemoptysis orbloodinthesputum(maybeduetodentalcausesorduetolungcausessuchas bronchitisortuberculosis).Checkifthecoughwithexpectorationisblood-tingedoris therefrankbloodinthesputum.Isthereanyhistoryofbronchitis,asthma,pneumonia, oremphysema?

CardiovascularSystem

Isthereanyhistoryofchestpainordiscomfortorpalpitations?Havethepalpitations beenassociatedwithsyncope(lossofconsciousness)?Isthereanyhistoryofeither hypertensionorhypotension?Doesthepatientexperienceanyparoxysmalnocturnal dyspnea(shortnessofbreathexperiencedinthemiddleofthenight)?Isthereanyshortnessofbreath(SOB)withexerciseorexertion?

Isthereanyhistoryoforthopnea(SOBwhenlyingflatinbed)?Doesthepatientuse morethanonepillowtosleep?Hasthisalwaysbeenthecase,orhasthepatientrecently startedusingmorepillows?

Isthereanyhistoryofedemaofthelegs,face,andsoon?Doesthepatientexperience anyhistoryoflegpainsorcramps?Arethecrampsrelievedbyrest?Ifso,thisissuggestiveofintermittentclaudication.Ifthecrampingorlegpainsareunremitting,itismore likelytobemuscularinorigin.

Isthereanyhistoryofmurmur(s),rheumaticfever,orvaricoseveins?Isthereany historyofhypercholesterolemia,gout,orexcessivesmokingthatcanleadtoorworsen heartdisease?

GastrointestinalSystem

Checkforahistoryofbleedinggums,oralulcers,orsores.Isthereanyhistoryofdysphagia(difficultyswallowing)?Canthepatientpointoutanddescribewherethedifficulty swallowingexists?Isthereanyhistoryofheartburn,indigestion,bloating,belching,or flatulence?Isthereanyhistoryofnausea?Isitrelatedtofood?Determinethefollowing:

Vomiting: Isthereanyassociatedweightloss?Aretherepsychosocialfactorsor medicationscausingit?

Hematemesis(vomitingblood): Askforassociatedulcerhistory,foodintolerance, abdominalpain,ordiscomfort.

Jaundice: Isthejaundiceduetoaviralcauseorgallstones?

Isthereahistoryofdiarrhea/constipationoranychangeincolorofstools?

GenitourinarySystem

Isthereahistoryofpolyuria(excessiveurination)duetodiabetes,renaldisease,oran unknowncause?Isitarecentchange?Isthereanyhistoryofnocturia(gettingupat nighttogotothebathroom)?Isthisarecentchange?Isthereanyhistoryofdysuria (painfulurination)?Ifdysuriaisbecauseofurinarytractinfection(UTI),frequencyand urgencywillalsobeexperienced.STDswillalsobeassociatedwithsimilarsymptoms. WithapositivehistoryofSTD,alwayschecktoseeiftreatmentforSTDwascompleted. Checkforrenalstones,painintheloins,andfrequentUTIs.

MenstrualHistory

Determinethedateofthelastmenstrualperiod.Neverforgettoparaphrasethisquestion,asdiscussedpreviously.Checkforanyhistoryofmenorrhagia(heavyperiods). Checkwhetherthepatientusesbirthcontrolororalcontraceptivepillsanddetailsof thetypeofcontraception.Letthepatientknowthatitisfirmlyestablishednowthatoral antibioticscanonlydecreasethepotencyofcombinedoralcontraceptivespills(COCPs) orprogesterone-onlycontraceptivepillswhenantibioticscause severepersistent diarrheaorvomiting,thusessentially“washingout”thepills.Itisonlythenthatthepatient willhavetouseextrabarrierprotectionuntiltheendofthenextcycletopreventpregnancy.ItiswelldocumentednowthatcertainmedicationslikeRifampinorantiseizure medicationsorazoleantifungalsthat induce cytochromeP450enzymesystem doaffect thepotencyof justtheCOCPs containingestrogenandprogesterone,asthesemedicationsnegativelyaffectthemetabolismofjustestrogenandnotprogesterone.Sowhileon theseenzyme-inducermedicationsincombinationwithCOCPs,thepatientwillhaveto usebarrierprotectiontopreventpregnancy.Antibioticsprescribedinthedentalsetting arenotCYP450enzymeinducers.Alwaysenteracasenoteintherecordstatingthatthe patienthasbeensoinformed.

MusculoskeletalSystem

Checkforahistoryofjointpainsandwhatjointsareaffected.Isthepainacuteorchronic, unilateralorbilateral,andisitinthemorningorintheevening?Arethereanysystemic symptoms?Isthereahistoryofrheumatoidarthritis,osteoarthritis,orgout?

EndocrineSystem

Checkforsymptomsassociatedwithdiabetes:polyuria(excessiveurination),polydypsia(excessivethirst),polyphagia(excessivehunger),orweightchange;thyroid: heat/coldintolerance,increased/decreasedheartrateorgoiter,andadrenals:weight change,easybruising,hypertension,andsoon.

NervousSystem

Checkforahistoryofstroke,cerebrovascularaccident/stroke(CVA),ortransient ischemicattack(TIA).Checkforahistoryofmuscleweakness,involuntarymovements duetotremors,seizures,oranxiety.Checkforhistoryofsensorylossofanykind,anesthesia(nosensation),parasthesias(alteredsensationcommonlyexperiencedaspinsand needles),orhyperesthesias(increasedsensations).Checkifthereisanychangeinmemory,especiallyarecentchange.

History-TakingConclusion

Itisimportantatthispointtocollecttherelevantdataorallpositivefindingsaboutthe patientandthenconstructalogicalframeworkofthecase.Youarenowabletodecide whichorganorbodyareaisaffectedandwheretofocusonduringphysicalexamination.

PHYSICALEXAMINATION:DETAILEDDISCUSSION

StructureandOverview

Thehistoryservestofocusonandprovidesemphasistothephysicalexaminationinthe sequenceofpatientworkup.Thepatientisexaminedfromheadtotoe,thusensuring thoroughnessandscreeningforabnormalities.Anyspecificphysicalfindingssuggested becauseofthehistoryfindingsaresought.

PHYSICALEXAMINATION:ASSESSMENTCOMPONENTS

Thefollowingarecomponentsofthephysicalexaminationinsequentialorder.

GeneralAppearance

Notethepatient’smentalstatus,abilitytointeract,speechpattern,neatness,andsoon.

VitalSigns:Pulse,RespirationRate,BloodPressure,Height,and Weight

Pulse

Notetherate,rhythm,volume,andregularityofthepulse.Countthepulserate/minute. Ifthepulserhythmisirregular,determinewhethertheirregularrhythmisregularor irregular.Anirregularity,morethan5beats/min,ispathologicalandshouldprompta consultwiththepatient’sMD(normalpulse:65–85beats/min).

RespirationRate

Notethebreathingpatternandtherespiratoryrate(RR)/min whiletaking thepulse, sothepatientisunawareandanxietydoesnotalterthebreathing(normalRR:12–16 breaths/min).

BloodPressureOverview

Takethebloodpressure(BP)inbotharmsduringthepatient’sfirstvisit.Alwaysobtain twobloodpressurereadings,takenfiveminutesapart,duringthepatient’sfirstvisit.If thebloodpressureishigh,confirmtheelevatedreadinginotherarmandthentaketwo morereadingsatthenextvisit.Anaverageofthreetofourreadingswilldeterminethe meanbloodpressureforthepatient.

Alwaysensurethatthepatienthasrestedsufficientlyinthechairpriortomonitoring theBP.Certainphysiologicalstatescanerroneouslyraisethebloodpressure.Stress,caffeine,heavymealconsumption,improperpositioningofthearm,orimpropercuffsize

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“Is some one ill?” she asked again.

“No; some one—some one is very well!” I managed to reply, lifting my eyes again to her wan face. The spectacle of its drawn lines and pallor all at once assailed my wearied and overtaxed nerves with crushing weight. I felt myself beginning to whimper, and rushing tears scalded my eyes. Something inside my breast seemed to be dragging me down through the stoop.

I have now only the recollection of Miss Stratford’s kneeling by my side, with a supporting arm around me, and of her thus unrolling and reading the proof-paper I had in my hand. We were in the hall now, instead of on the stoop, and there was a long silence. Then she put her head on my shoulder and wept. I could hear and feel her sobs as if they were my own.

“I—I didn’t think you’d cry—that you’d be so sorry,” I heard myself saying, at last, in despondent self-defence.

Miss Stratford lifted her head and, still kneeling as she was, put a finger under my chin to make me look her in her face. Lo! the eyes were laughing through their tears; the whole countenance was radiant once more with the light of happy youth and with that other glory which youth knows only once.

“Why, Andrew, boy,” she said, trembling, smiling, sobbing, beaming all at once, “didn’t you know that people cry for very joy sometimes?”

And as I shook my head she bent down and kissed me.

BIBLIOGRAPHICAL NOTE

[Since any list approaching a complete bibliography would be unduly long, these suggestions are merely for the convenience of those who, without special research, wish to read further and compare. They remain after rejection of many essays that seem hardly to advance the discussion.]

Cairns, William B., On the Development of American Literature from 1815 to 1833, with especial reference to periodicals; Bulletin of the University of Wisconsin, Philology and Literature Series, volume i, no. 1, pages 1–87.

Canby, Henry Seidel, The Short Story; Yale Studies in English, xii (revised as introduction to The Book of the ShortStory, edited by Alexander Jessup and Henry Seidel Canby).

Chassang, A., Histoire du Roman ... dans l’Antiquité GrecqueetLatine; Paris (2d ed.), 1862.

Gilbert, E., LeRomanenFrancependantlexixe Siècle; Paris (2d ed.), 1896.

Hart, Walter Morris, The Evolution of the Short Story; address delivered before the Alumni Association of Haverford College, June 12, 1901.

Matthews, Brander, The Philosophy of the Short Story; New York, 1901. (This, the standard essay on the subject, is now published separately, with notes and a few striking references.)

Moland et d’Héricault, Nouvelles Françoises en Prose du xiiime Siècle; Paris, 1856 (l’Empereur Constant, Amis et Amile, le Roi Flore et la Belle Jehane, la Comtesse de Ponthieu, Aucassin et Nicolette; introduction, notes).

Morris, William, OldFrenchRomancesdoneintoEnglishby William Morris, with introduction by Joseph Jacobs; London, 1896 (translation of the same tales as in the preceding, except Aucassin and Nicolette).

Peck, Harry Thurston, Trimalchio’s Dinner by Petronius Arbiter, translated from the original Latin, with an introduction and bibliographical appendix; New York, 1898. (The introduction discusses prose fiction in Greece and Rome.)

Perry, Bliss, AStudyofProseFiction; Boston, 1902.

FOOTNOTES

1 Donald G. Mitchell, AmericanLandsandLetters.

2 LiteraryPapersofWilliamAustin, Boston, 1890, page 43.

3 See Prof. William B. Cairns, On the Development of American Literature from 1815 to 1833, with especial reference to periodicals; Bulletin of the University of Wisconsin, Philology and Literature Series, volume i, No. 1.

4 For a pungent characterisation of the annuals, see Prof. Henry A. Beers’s life of N. P. Willis (American Men of Letters), pages 77 and following.

5 Fromentin (Un ÉtédansleSahara, page 59; Une Annéedans leSahel, pages 215 and following) lays this down for painting.

6 Bret Harte, The Rise of the Short Story, Cornhill Magazine, July, 1899.

7 See Cairns, as above, page 64. The influence of the Spectator form in France appears strikingly in L’Hermite de la Chaussée d’Antin, ou observations sur les mœurs et les usages français au commencement du xixme siècle, par M. de Jouy, Paris (collective volumes), 1813.

8 Cross, DevelopmentoftheEnglishNovel, pages 24, 25.

9 For Irving’s own view of his tales, see a quotation from his letters at page xix of Professor Brander Matthews’s edition of

the TalesofaTraveller.

10 “A rivulet of story meandering through a broad meadow of episode—a book of episodes with occasional digressions into the plot.” Kennedy’s preface to SwallowBarn.

11 This is the character of the tales of Mme. de Genlis, of which a volume was published in New York, 1825: New Moral Tales, selectedandtranslatedfromtheFrenchofMme.deGenlis,by anAmerican.

12 Nodier adopts the same setting for the same purpose (cf. Les Quatre Talismans, 1838); but the habit is at least as old as Voltaire.

13 So Godfrey Wallace’s Esmeralda, Atlantic Souvenir for 1829.

14 Miss Sedgwick’s Chivalric Sailor (1835) is essentially like our current historical romances. A typical instance is Dana’s Paul Felton(1822).

15 This tendency was confirmed, of course, by the predominance of Scott.

16 Brander Matthews, The Philosophy of the Short-Story, page 15.

17 Poetics, chapter x.

18 Poe’s review of Hawthorne’s tales (1842) begins by remarking that they are not all tales (Stedman and Woodberry edition of Poe, vol. vii, page 28).

19 Poe’s tales were translated into French, German, Italian, and Spanish. He was reviewed in the RevuedesDeuxMondes, Oct. 15, 1846 (new series, vol. xvi, page 341).

20 See Aristotle’s Poetics, chapters vii and viii. The “classical” French drama deduced from Aristotle’s general principle of

unity of action a strict system of practice. Of Poe’s adherence to this system a good instance is TheCaskofAmontillado.

21 In a review of Mrs. Sigourney, Southern Literary Messenger, volume ii, page 113 (January, 1836); quoted in Woodberry’s Life of Poe, page 94.

22 In a review of Hawthorne, Graham’s Magazine, May, 1842; Stedman and Woodberry’s edition of Poe, volume vii, page 30; quoted in the appendix to Brander Matthews’s Philosophy of theShort-Story.

23 A collection ascribed to Antonius Diogenes, compiled by Aristides of Miletus, was translated into Latin by Cornelius Sisenna (119–67 B.C.). The translation is lost.

24 The Cena of Petronius has more consistency, is in form more like the longer tales of antiquity.

25 The object of Lucian is always satire. This, not any purely narrative end, determines his method. But it is worth observing that The Ass is picaresque. For the rest, no single adventure of the string is more than anecdote.

26 The Greek title is ποιμενικά.

27 E.g., the fifteenth idyl of Theocritus, and the opening of the seventh oration of Dio Chrysostom. The latter, though brought in as anecdote, has extraordinary ingenuity and finish of form.

28 See the introduction by Joseph Jacobs to Old French RomancesdoneintoEnglishbyWilliamMorris.

29 This, perhaps, is typically the novella; but Boccaccio will not fix the term: “intendo di raccontare cento novelle, o favole o parabole o istorie, che dire le vogliamo ... nelle quali novelle....”—PrefacetoDecameron.

30

For reference in more detailed study of mediæval forms, this tentative classification of the Decameron may be tabulated as follows:

anecdote

(a) simpleanecdote 34

I, all but nov. 4; III, nov. 4; V, nov. 4; VI, entire; VIII, all but nov. 7 & 8; IX, nov. 1 & 7–10.

(b) anecdotemoreartisticallyelaborated 21

III, nov. 1, 2, 3, 5, 6; V, nov. 10; VII, entire; VIII, nov. 7; IX, nov. 2–5. scenarioorsummaryromance

55

40

II, nov. 3–10; III, nov. 7–10; IV, entire; V, all but nov. 4 & 10; X, entire. approachingshortstory 3

I, nov. 4; II, nov. 1; VIII, nov. 8. shortstory 2

II, nov. 2; IX, nov. 6.

100

31 E. Gilbert, LeromanenFrancependantlexixe siècle, page 65; A. France, Lavielittéraire, Ire série, page 47.

32 Brander Matthews, The Philosophy of the Short-Story, page 65.

33 Colombahas one hundred and fifty pages.

34 See an essay on The Literary Influence of Sterne in France, Publications of the Modern Language Association of America, volume xvii, pages 221–236.

35 It would be interesting, for instance, to determine whether Mérimée learned anything in form from Poushkin.

36 Vide the excellent discourse of G. C. Verplanck, Esq., before the New York Historical Society.

37 Not in the first edition.

38 In New Hampshire.

39 In the original publication the name is Patience.

40 [“In place of this clause the first edition has: “Her figure, her air, her features,—all, in their very minutest development were those—were identically (I can use no other sufficient term) were identically those of the Roderick Usher who sat beside me. A feeling of stupor,” etc.]

41 Watson, Dr. Percival, Spallanzani, and especially the Bishop of Llandaff. See Chemical Essays, vol. v.

42 The season of peach-blossoms was the only season of marriage in ancient China.

43 The most common decorations of rooms, halls, and temples, in China, are ornamental scrolls or labels of colored paper or wood, painted and gilded, and hung over doors or windows, and inscribed with a line or couplet conveying some allusion to the circumstances of the inhabitant, or some pious or philosophical axiom. For instance, a poetical one recorded by Dr. Morrison:

“From the pine forest the azure dragon ascends to the milky way,” typical of the prosperous man arising to wealth and honors.

INDEX

[Titles ofbooks andperiodicals are inquotation marks; titles ofseparate stories, in italics]

Addison, a model for Irving, 6

Aldrich, Thomas Bailey, 34

AliceDoane’sAppeal(Hawthorne), 13

Allegory, 10, 14, 23, 230

AmbitiousGuest,The(Hawthorne), 14

American literature, brevity of, 1; wherein American, 1–4, 8, 35; American life in, 3–6, 11, 12

“American Monthly Magazine, The,” 113

AmisandAmile, 25

Anecdote, 10, 24, 26, 27, 29

Annuals, American, 2, 4, 5, 9–12, 18

Antonius Diogenes, 24

“Appleton’s Journal,” 245

Apuleius, 30

Aristides of Miletus, 24

Aristotle, “Poetics,” 13, 19, 20

ArsèneGuillot(Mérimée), 31

Artificiality in short story, 20, 32

“Ass, The,” of Lucian, 24

“Atlantic Monthly, The,” 247

“Atlantic Souvenir, The,” 2, 4, 5, 11

AucassinandNicolette, 25, 27, 31

Austin, William, 1, 10, 12, 59–95; biographical and critical sketch, 59; JosephNatterstrom, 1, 10; PeterRugg, 10, 12, 60–95

Bacon, Delia, 11

Balzac, Honoré de, 32–33; Elverdugo, Lesproscrits, Lamessedel’athée, Z.Marcas, 32; form in, 32–33

Bandello, 29

Beckwith, Hiram W., 97

Bee-Tree,The(Kirkland), 195–210

Beers, Henry A., 2, 177

BenHadar(Paulding), 10

Berenice(Poe), 2, 3, 16, 18, 21, 22, 33

Blackwell, Robert, 97

Boccaccio, “The Decameron,” 26–28, 30

“Boston Book, The,” 61

Brunetière, Ferdinand, 26

BuckthorneandHisFriends(Irving), 8

Bunner, Henry Cuyler, 289–301; biographical and critical note, 289; TheThirdFigureoftheCotillion, 289; TheLoveLettersofSmith, 291–301

Burton’s “Gentleman’s Magazine,” 154

Cable, George W., 5, 34; PossonJone, 34

Cairns, William B., 2, 6, 325

Canby, Henry Seidel, 325

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