A4M

Dear Esteemed Colleagues,

Longevity is no longer an abstract concept; it’s a new reality taking shape in clinics, laboratories, and conversations around the globe. As our field enters mainstream focus and the race toward trend capitalization begins, we are faced with a profound question: how can we ensure longevity remains steadfastly rooted in evidence-based whole-person care?

You are at the very heart of the answer:

Welcome to the 33rd Annual A4M Spring Congress.

For over three decades, you have stood at the forefront of advancing longevity medicine. Now, this is your opportunity to define its practice, not merely as a passing trend or buzzword – but as a resolute commitment to extending the human healthspan with precision, responsibility, and integrity.

Today, a systemic disconnect threatens the foundation we have worked so hard to build: mainstream interest and investment focus primarily on extending life – often without equal consideration for the quality of those added years. As misinformation proliferates, profit takes precedence over patient outcomes, and quick-fix solutions eclipse data-driven protocols, we lose ground in our shared mission to deliver true health optimization.

Longevity without vitality is not progress.

A recent survey found that 66% of Americans would rather live a shorter yet healthier life than one with additional years burdened by illness, disability, or dysfunction. Our mission is to align lifespan with healthspan, empowering the population to not just live longer, but to live healthier, more vibrant, and more fulfilling lives.

This Congress is designed to equip you with the tools, insights, and network to lead by example – to practice functional, personalized care, ensuring extended lives are met with resilience, fulfillment, and quality. Scientific advancements can expand human potential, but the collective dedication of practitioners like you is what ensures that potential is realized responsibly and ethically.

Living Longer, Living Better: The Promise of Longevity Medicine

This year’s theme invites you to define how longevity is practiced – not as the singular pursuit of extending life but as a meaningful dedication to enhancing its quality. More importantly, it’s a call to action.

We’ve assembled an extraordinary lineup of speakers who translate theory into actionable clinical strategies. Gathered here are pioneers in genomics, reproductive longevity, cellular aging, personalized medicine, and neuroscience – includ-

ing Jennifer Garrison, PhD, Hellen Messier, MD, PhD, CCFP, Dave Rabin, MD, PhD, and dozens more.

Over the next few days, our experts will guide you through validated interventions with industry-leading impact. Every session ahead is intentionally designed to address persistent challenges with effective solutions – be it metabolic dysfunction overlooked by conventional medicine, hormonal imbalances dismissed as normal aging, or the untapped potential of cellular resilience.

The promise of longevity medicine is vast, but its fulfillment depends on practitioners like you who pair specialized expertise with clinical discernment and the latest science with practical application.

For the past 33 years, this community has shattered convention, outpacing expectations and achieving what was once deemed impossible. Your questions, case studies, and personal breakthroughs form the cutting edge of healthcare, driving forward innovation in ways textbooks and traditional CME never could.

With immense appreciation for your commitment, we eagerly anticipate the new pathways forged, strategic collaborations, and measurable progress that will emerge from this gathering. Your presence here signifies your role not just as a participant but as a vital architect of this movement.

Take these next few days to reinvigorate your vision for longevity beyond lifespan. Exchange bold ideas, ask boundary-pushing questions, and return home empowered to deliver not just longer lives but truly better ones.

Here’s to the next chapter in medical history – built on the promise of longevity, shaped by your collective wisdom, Ronald Klatz, MD, DO & Robert M. Goldman, MD, PhD A4M Founders

Ronald Klatz MD, DO Co-Founder

Robert Goldman MD, PhD, DO, FAASP Co-Founder

SHOW REGULATIONS

1. An official picture ID is required to pick up name badge.

2. Name badge must be worn at all times during show hours and official events.

3. No one under the age of 18 will be admitted into the Exhibit Hall.

4. This event is open to healthcare professionals and their invited guests only.

5. Photography is permitted in the Exhibit Hall only by press, with the prior permission of show management, and prior permission from the firm(s) whose booth(s) are being photographed. Videography in the Exhibit Hall (motion video, film, or digital) is permitted only at discretion and with advance permission of show management and the prior permission of individual(s) and/or firm being photographed.

6. Audio and video recording (tape or digital) of this event is expressly prohibited.

7. Unauthorized solicitation is prohibited. In addition, non-A4M and/or commercial literature of any kind may not be distributed near or at the event registration area and all event-related general public areas.

8. No medical procedures are permitted to take place in Exhibit Hall booths without prior permission of show management.

9. Show management reserves the right to expel any individual and/or company without recourse or refund at its sole discretion.

10. PHOTO RELEASE: Anyone in attendance at any A4M event may be subject to any photography or videography conducted during the event which may be used in any form for future media purposes. Please contact A4M with any concerns.

The American Academy of Anti-Aging Medicine (A4M.) All rights reserved. ISSN 1533-6700. Anti-Aging Medical News publishes materials in good faith and makes no claims or endorsements for products, services or procedures that appear in the publication. Opinions expressed in articles and advertisements are not necessarily those of Anti-Aging Medical News, its owners, affiliates, or its staff. The publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Under no circumstances is the content of Anti-Aging Medical News to be construed as medical advice. Always consult your personal physician prior to beginning a new therapy, or

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ARTICLES

By: Antonia Toupet, PhD

By: Nell Fitzgerald Jonathan Wright

By: Jim LaValle, RPh, CCN, MT

By: Nina Crowley, PhD, RD

By: Erika Schwartz, MD

By: Joseph M. Raffaele, MD

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EVENING WORKSHOPS

THURSDAY | APRIL 24TH

6:15 pm

Updates on Prescribing GLP-1 and Growth Hormone for Your Practice

Presented by: Dave Metayer

Barbie Barrett, MD

Andrew Jurow, MD

Location: Oceana Ballroom B

Mind Matters

Optimizing Brain Health & Memory for a Sharper Future

This session will examine the critical roles of gut health, diet, hormones, and environmental causes of inﬂammation in cognitive function, providing interventions that can be implemented immediately. Attendees will gain practical tools, including key functional medicine labs and clinical protocols, to enhance patient outcomes and address cognitive decline proactively.

Join us for this non-CME evening workshop!

•Friday, April 25th at 6:15pm

•PBCC- Ballroom B

P R E S E NTED B Y

Melanie Dorion, AGNP-BC

Melanie Dorion is an Integrative and Functional Nurse Practitioner, founder and Medical Director at Be Vital Health Center. She focuses on managing and reversing chronic illnesses, disease prevention and health optimization.

Connect with colleagues, enjoy great food, and get valuable insights into brain health and memory!

Scan the QR to let us know you’re attending, and get early access to exclusive educational downloads from the workshop.

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36 Metabolic and Biochemical Pathways

April 24 - 26, 2025

West Palm Beach, Florida

• Weight Balance

6 Key Health Areas

• Heart Health

• Blood Sugar Regulation

• Brain Health

• Fitness & Tissue Health

Keep a look out for Dr. Yael Joffe PhD, our Founder & Chief Science Ofﬁcer as well as our 3X4 Team who will be at the 33rd Annual Spring Congress in West Palm Beach to answer any questions about our 3X4 Genetics Test and 3X4 Blueprint.

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Muscle Tone Matters in Healthy Aging:

The Key to Optimal Body Composition and Metabolic Health

By: Antonia Toupet, PhD

Science Writer for Designs for Health

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine. The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Muscle tone is traditionally defined as the residual tension in a relaxed muscle or the passive partial contraction of the muscle during a resting state.1 Physical activity, especially resistance training, is considered an integral part of maintaining muscle tone by stimulating muscle protein synthesis and increasing or maintaining muscle mass. Muscle loss, on the other hand, has been associated with delayed recovery from illness, impaired wound healing, reduced resting metabolic rate, physical disability, poorer quality of life, and higher health care costs.2

Body composition can be measured in multiple ways, but in general, it refers to the amount and distribution of body fat and lean body mass.3 For example, people of the same height, gender, and weight may have different body types and compositions depending on their percentage distribution of fat, bone, water, and muscle. Optimal body composition has been associated with numerous health outcomes and may play an integral role in healthy aging and the risk factors for several diseases, such as cardiovascular disease, diabetes, osteoporosis, and osteoarthritis.4

Muscle Tone Matters

Aging:

Exercise and increasing muscle mass and tone can be an effective way to improve body composition. It has been shown to decrease body fat and increase lean body mass, thus improving overall body composition and promoting a healthy aging process.5 There is support for various exercise modalities that can improve body composition. A randomized control trial (RCT) (n = 89) showed that all types of exercise can improve the body composition of individuals with a sedentary lifestyle; however, strength training programs that develop the entire body may show the greatest impact.6 A meta-analysis comparing the effectiveness of several different types of exercise for overweight and obese individuals found that combined aerobic and resistance training improved body composition and inflammatory status the most.7 Finally, an overview of 12 systematic reviews and 149 controlled trials concluded that exercise favorably impacted body composition by reducing total and visceral fat.8

Metabolic health refers to how well the body generates and processes energy, considering cardiovascular risk, blood sugar regulation, blood pressure, and waist circumference.9 Metabolic health is required for healthy aging. According to a study based on the National Health and Nutrition Examination Survey, the prevalence of metabolic health in American adults is alarmingly low, posing serious individual and public health concerns.9 Muscle tone, maintained through physical activity, can be a powerful regulator of insulin sensitivity and overall metabolic health, with short-term benefits stemming from each training session and long-term adaptations that improve overall body composition.

The skeletal muscle is the largest metabolic tissue in the human body and an important site for glucose metabolism, both during exercise and while at rest.10 It is also regarded as an endocrine and paracrine organ, where muscle-derived proteins, called myokines, facilitate interactions between the muscles and other organs, such as the liver, pancreas, skeletal system, adipose tissues, and the cardiovascular system. During exercise, the muscles are used as a source of fuel for both muscle-stored glycogen and circulating plasma glucose, activating glucose metabolism through insulin-dependent mechanisms and optimizing insulin response and glucose oxidation.11 Routine exercise

further increases skeletal muscle tone, oxidative capacity, and mitochondrial biogenesis, leading to even greater glucose uptake.12 Muscles also influence energy and protein metabolism throughout the body by acting as a reservoir of amino acids, which can be released when needed elsewhere in the body.2 An observation study found that lower muscle mass was a risk factor for metabolic syndrome among people over 65 with normal body mass index.13 Regular exercise and improved muscle tone may improve metabolic health and reduce the risk for metabolic disease, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease.11

What are some nutrients that can support muscle tone and healthy body composition for healthy aging?

Collagen peptides have been shown to support the maintenance of collagen, the primary structural component of connective tissues, accounting for as much as 30% of the body’s total protein.14 Collagen is responsible for muscle flexibility and adaptation and provides structure, support, and strength to muscles, helping them function properly.15

An RCT (n = 53) found that male subjects with sarcopenia who were supplemented with collagen peptides following resistance training achieved improved body composition by increasing lean body mass more than the control group, who completed the same resistance training but without the collagen peptide supplementation.16 Another RCT (n = 77) investigated the effect of collagen peptide supplementation on the body composition and muscle strength of premenopausal women and found that subjects who received the collagen peptides increased lean body mass, hand-grip strength, and leg strength significantly more than the control group.17

Creatine is primarily stored in skeletal muscle and involved in muscular contractions. Both muscle strength and creatine levels naturally decline with age.18 Supplementation has been shown to increase intramuscular creatine concentrations, high-intensity exercise capacity, and lean body mass.19 A metaanalysis showed that older adults who receive creatine supplementation had increased lean body mass and muscle strength during resistance training. 20

Leucine is the essential amino acid that is considered to be the most anabolic.21 For effective muscle stimulation and protein synthesis, the International Society of Sports Nutrition recommends resistance exercise and adequate protein consumption in the range of 1.4 to 2 grams per kilogram of body weight per day (g/kg/d). A higher protein intake of 2.3 to 3.1 g/kg/d may be needed to maximize the retention of lean body mass in resistance-training individuals, where the protein source should contain 700 to 3,000 mg of leucine, in addition to a balanced content of all essential amino acids.22 A systematic review of 16 RCTs found that individuals 65 years or older supplemented with leucine experienced beneficial effects on body weight and lean body mass.23

Other nutrients that may support muscle tone and a healthy body composition include peptides from the fava bean (Vicia faba), whey protein, β-hydroxy βmethylbutyrate, vitamin D, and geranylgeraniol (GG).24–28 As the body ages, a combination of regular exercise, a nutrient-dense whole foods diet, and targeted supplementation, when needed, can support muscle health and overall well-being.

Author:

Antonia Toupet has a PhD in Behavioral and Experimental Economics and experience with data science and clinical research. She is a Science Writer for Designs for Health, a CNS candidate, and a certified health coach. atoupet@ designsforhealth.com

Designs for Health (DFH) is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.* This dedication to quality and passion for the industry, along with the DFH team who share these values, is why DFH customers have remained loyal to the brand for 35 years.

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References:

1. Ganguly J, Kulshreshtha D, Almotiri M, Jog M. Muscle tone physiology and abnormalities. Toxins (Basel). 2021;13(4):282. doi:10.3390/toxins13040282

2. Argilés JM, Campos N, Lopez-Pedrosa JM, Rueda R, RodriguezMañas L. Skeletal muscle regulates metabolism via interorgan crosstalk: roles in health and disease. Journal of the American Medical Directors Association. 2016;17(9):789-796. doi:10.1016/j. jamda.2016.04.019

3. Kuriyan R. Body composition techniques. Indian J Med Res. 2018;148(5):648-658. doi:10.4103/ijmr.IJMR_1777_18

4. Holmes CJ, Racette SB. The utility of body composition assessment in nutrition and clinical practice: an overview of current methodology. Nutrients. 2021;13(8):2493. doi:10.3390/nu13082493

5. Drenowatz C, Hand GA, Sagner M, Shook RP, Burgess S, Blair SN. The prospective association between different types of exercise and

body composition. Med Sci Sports Exerc. 2015;47(12):2535-2541. doi:10.1249/MSS.0000000000000701

6. Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L, Ruiz JR, Castillo MJ, Gutiérrez Á. Effects of different exercise training programs on body composition: a randomized control trial. Scand J Med Sci Sports. 2019;29(7):968-979. doi:10.1111/sms.13414

7. Wang S, Zhou H, Zhao C, He H. Effect of exercise training on body composition and inflammatory cytokine levels in overweight and obese individuals: a systematic review and network meta-analysis. Front Immunol. 2022;13:921085. doi:10.3389/fimmu.2022.921085

8. Bellicha A, van Baak MA, Battista F, et al. Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity: an overview of 12 systematic reviews and 149 studies. Obes Rev. 2021;22 Suppl 4(Suppl 4):e13256. doi:10.1111/obr.13256

9. Araújo J, Cai J, Stevens J. Prevalence of optimal metabolic health in American adults: National Health and Nutrition Examination Survey 2009-2016. Metab Syndr Relat Disord. 2019;17(1):46-52. doi:10.1089/met.2018.0105

10. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab 2013;17(2):162-184. doi:10.1016/j.cmet.2012.12.012

11. Kim G, Kim JH. Impact of skeletal muscle mass on metabolic health. Endocrinol Metab (Seoul). 2020;35(1):1-6. doi:10.3803/ EnM.2020.35.1.1

12. Holloszy JO. Regulation of mitochondrial biogenesis and GLUT4 expression by exercise. Compr Physiol. 2011;1(2):921-940. doi:10.1002/cphy.c100052

13. Moon JH, Choo SR, Kim JS. Relationship between low muscle mass and metabolic syndrome in elderly people with normal body mass index. J Bone Metab. 2015;22(3):99-106. doi:10.11005/ jbm.2015.22.3.99

14. Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021;53(10):1493. doi:10.1007/s00726-02103072-x

15. Holwerda AM, van Loon LJC. The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: a narrative review. Nutr Rev. 2022;80(6):1497-1514. doi:10.1093/ nutrit/nuab083

16. Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114(8):1237-1245. doi:10.1017/S0007114515002810

17. Jendricke P, Centner C, Zdzieblik D, Gollhofer A, König D. Specific collagen peptides in combination with resistance training improve body composition and regional muscle strength in premenopausal women: a randomized controlled trial. Nutrients. 2019;11(4):892. doi:10.3390/nu11040892

18. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18. doi:10.1186/s12970-017-0173-z

19. Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB. Creatine for exercise and sports performance, with recovery considerations for healthy populations. Nutrients. 2021;13(6):1915. doi:10.3390/nu13061915

20. Chilibeck PD, Kaviani M, Candow DG, Zello GA. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis. Open Access J Sports Med. 2017;8:213-226. doi:10.2147/OAJSM.S123529

21. Devries MC, McGlory C, Bolster DR, et al. Leucine, Not Total Protein, Content of a supplement is the primary determinant of muscle protein anabolic responses in healthy older women. J Nutr. 2018;148(7):1088-1095. doi:10.1093/jn/nxy091

22. äger R, Kerksick CM, Campbell BI, et al. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017;14:20. doi:10.1186/s12970-017-0177-8

23. Komar B, Schwingshackl L, Hoffmann G. Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: a systematic review and meta-analysis. J Nutr Health Aging. 2015;19(4):437-446. doi:10.1007/s12603-014-0559-4

24. Kerr A, Hart L, Davis H, et al. Improved strength recovery and reduced fatigue with suppressed plasma myostatin following supplementation of a Vicia faba hydrolysate, in a healthy male population. Nutrients. 2023;15(4):986. doi:10.3390/nu15040986

25. Kim CB, Park JH, Park HS, Kim HJ, Park JJ. Effects of whey protein supplement on 4-week resistance exercise-induced improvements in muscle mass and isokinetic muscular function under dietary control. Nutrients. 2023;15(4):1003. doi:10.3390/nu15041003

26. Bear DE, Langan A, Dimidi E, et al. β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis. Am J Clin Nutr. 2019;109(4):1119-1132. doi:10.1093/ajcn/nqy373

27. Rathmacher JA, Pitchford LM, Khoo P, et al. Long-term effects of calcium β-hydroxy-β-methylbutyrate and vitamin D3 supplementation on muscular function in older adults with and without resistance training: a randomized, double-blind, controlled study. J Gerontol A Biol Sci Med Sci. 2020;75(11):2089-2097. doi:10.1093/gerona/glaa218

28. Jaśkiewicz A, Pająk B, Łabieniec-Watała M, Palma CD, Orzechowski A. Diverse action of selected statins on skeletal muscle cells-an attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med. 2019;8(5):694. doi:10.3390/jcm8050694

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Test Your Luck!

Stop by the Doctor's Data booth all weekend to spin the reels to win great prizes such as an iPad, a free GI360TM kit, a free HuMapTM kit, and more!

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How IgG/C3d Food Sensitivity Screening Can Reduce General Inflammatory Symptoms

By: Nell Fitzgerald, Jonathan Wright KBMO Diagnostics

Abstract

Objective: To evaluate the effectiveness of an IgG/ C3d-based elimination diet in reducing inflammatory symptoms. Methods: Food sensitivities of 74 participants in Chengdu, China were identified by screening for IgG/C3d against a microarray of food antigens. Participants complied with personalized elimination diets based on the results, and changes to initial reported symptoms were evaluated. Results: Most participants (82.4%) reported a reduction in symptom severity following the elimination diet,

suggesting an association with IgG/C3d mediated food sensitivity and the adverse symptoms studied. Symptoms were categorized by the body system affected; gastrointestinal, dermal, nasal, neurological, musculoskeletal, body weight, insomnia, fatigue, and other. Conclusions: Reductions in inflammatory symptoms were observed after subjects underwent IgG/C3d-based elimination diets, supporting further research into the relevance of IgG/C3d as a sensitive biomarker of food sensitivity.

How IgG/C3d Food Sensitivity Screening Can Reduce General Inflammatory Symptoms

Introduction

Food hypersensitivity constitutes a diverse range of inflammatory symptoms that affect 5-20% of the global population.1 Distinct from Type I IgE mediated food allergy or food intolerance, hypersensitivity is immunoglobulin G (IgG) mediated, and may trigger a range of delayed symptoms, including gastrointestinal discomfort, joint pain, brain fog, and dermatitis. Most patients show delayed sensitivity to at least one of the eight food antigens (milk, eggs, fish, crustaceans, tree nuts, peanuts, wheat, and soybeans), which are responsible for 90% of food sensitivities worldwide.2 In addition, a rise in hidden allergens that may not appear on food labels may increase the difficulty of detecting food-related delayed hypersensitivities and identifying offending foods.3 Food sensitivities may lead to a lower quality of life and require careful personalized dietary and lifestyle management from a healthcare professional.

IgG-mediated food sensitivity is involved in two of the four types of hypersensitivity. Type I hypersensitivity is mediated by Immunoglobulin E (IgE), and is associated with the acute, adverse allergic reaction that results in histamine release and systemic or localized anaphylaxis.4 Type II hypersensitivity is a cytotoxic response mediated by IgG and immunoglobulin-M (IgM) antibody, and Type III hypersensitivity involves IgG or IgM immune complex reactions. Type IV sensitivities are hypersensitivities that are delayed cell-mediated immune responses in which T-cells mount inflammatory responses against endogenous or exogenous antigens.5 There is evidence to support that Type II and III hypersensitivities have significant inflammatory implications due to the activation of the complement system.

While the immunological mechanisms behind food sensitivities are debated, it is thought that the complement system may be one pathway through which certain foods trigger systemic inflammation.6 The complement system is an essential interface between the adaptive and innate immune systems as these systems produce proteins that guide leukocytes to infection sites.7 In the classical pathway, IgG1,3 activates the complement cascade, producing C1q leading to a conformational change that causes autocatalytic enzyme activity. Protein subunits

produce a serine zymogen that cleaves the protein complex C4 to the subunits C4a and C4b. C4b forms a complex that cleaves circulating C2 into C2a and C2b. C2b binds to C4b to form C4b2a (C3 convertase) that then cleaves circulating C3. C3 is then cleaved into the protein subunits C3a and C3b. The former is a peptide mediator in inflammation (anaphylatoxin) for the recruitment of neutrophils and monocytes while the latter covalently opsonizes to the membranes of pathogens. C3b then covalently binds to C3 convertase to form the protease C5 convertase which then cleaves circulating C5. C3b also opsonizes to pathogen surfaces to tag for phagocytosis. In the C5 convertase complex, circulating C5 and is then cleaved into C5a and C5b .8 Like C3a and C2a, C5a is an anaphylatoxin while C5b binds to C9 and forms a membrane attack complex, causing the lysis of pathogens.9 C3b can be cleaved by the plasma protein complement factor 1 (CF1) in concurrence with complement receptor 1 (CR1) and membrane-factor of proteolysis (MCP) into inactive fragments of iC3b.8 Furthermore, CF1 and CR1 cleaves iC3b into C3dg. Serum proteases cleave C3dg in the protein subunit C3d.9 This particular protein subunit binds to antibodies such as IgG and initiates B-cells to attack the bound pathogens.10

Complement receptors CR2 and CD25 coordinate with B-cell antigen receptors (BCR) to respond to antigens bound to C3d, which enhances the immune response when conjugated with an antibody.10,11 When antibody/ C3d complexes bind to pathogen cell surfaces, B-cells are recruited to the binding site and the threshold to produce antibodies is lowered. 12-13 This results in an increase in antibody production from B cells and an enhancement in the IgG-mediated inflammatory response. 4 In this way, measuring IgG/C3d immune complex may be indicative of food-related inflammation. 9

Research also suggests that intestinal permeability and epithelial dysfunction plays a role in mediating food sensitivities, which may manifest in conditions such as Crohn’s disease and irritable bowel syndrome (IBS). Intestinal permeability is a functional attribute of the digestive system allowing for nutrient absorption while maintaining a barrier to prevent potentially harmful lumen products from entering circulation.14 When inconsistent fluctuations of permeability occur for extended periods

of time and there is a decline in essential structural and regulatory protein expression, intestinal permeability occurs. Dietary factors can influence changes in gut microbiota that can negatively influence permeability.15 Delayed food sensitivities (i.e. Types II and III) can initiate a change in microbial species diversity and population proportions in the gut.16 An imbalance within the gut microbiota can compromise tight junction (TJ) proteins, such as occludin, claudin-3,-4,- & -5, as well as regulatory proteins like zonulin, leading to a breakdown of TJ barriers in the digestive lining. 15

Increased intestinal permeability as a result of food-related inflammation can cause ions, proteins, gut microbiota, and other lumen products to translocate into the bloodstream which triggers the formation of IgG/C3d immune complex through the complement pathway. Regulatory proteins, particularly zonulin, play a crucial role in controlling the degree of intracellular structure along digestive epithelia. When zonulin proteins permit excessive transport of intestinal contents, the immune system can generate IgG/ C3d responses that are associated with inflammation .9 Impaired intestinal permeability has links to gastrointestinal conditions such as Crohn’s disease and ulcerative colitis. In the former, reduced expression of occludin, claudin-3,-5, & -8 have been observed while the latter shows a reduced expression in claudin-1 & -4, along with an increased expression of pore-forming claudin-2. 15 It should be noted that less than 10% of patients with genetic susceptibility to intestinal permeability develop the condition, and environmental factors, possibly food antigens absorbed through the gut epithelia, are most likely to contribute. Evidence supports that such dysfunction of paracellular structural proteins could be linked to diseases such as Type 1 diabetes, Celiac disease, and even some cancers.17 Studies suggest that IgG-mediated food sensitivities may be associated with a wide range of chronic inflammatory disorders, including dermatitis and gastrointestinal distress, and may result from sensitivities to the same types of food.18 In addition, chronic inflammatory diseases such as arthritis and multiple sclerosis may be associated with food sensitivity as a result of intestinal permeability. 19 Recent research has found that sleep deprivation may be associated with inflammatory conditions, including inflammatory bowel disease (IBD), gut microbiome dysbiosis, and obesity.20 It is suggested that sleep deprivation that results

from chronic inflammatory conditions may also exacerbate these symptoms.21 In addition, patients with diseases such as rheumatoid arthritis and hepatitis, IgG levels are elevated. Even asymptomatic patients who are positive for IgG antibody against certain foods may be at risk for developing conditions later in life.22

Research has shown that elimination of IgG-specific foods through elimination or rotation diets can mitigate adverse clinical symptoms and reduce food-specific IgG titers leading to improvements in patients’ health.9 IgGbased elimination diets may be therapeutically effective in treating IBS, as well as quality of life, anxiety and depression, and non-gastrointestinal inflammatory conditions, as compared to alternate or sham dietary approaches.23 Compliance with IgG-based elimination diets may significantly reduce GI symptoms in IBS populations.24 Compared to low FODMAP and general healthy eating diets, IgG elimination diet was shown to lead to a significant decrease in symptoms.25 IgG-based elimination diets may also reduce migraine symptoms, as well as abdominal pain in participants with IBS.26,27

Recent work has also shown that most patients suffering from Crohn’s disease show improved symptoms following a food-specific elimination diet.28,29 With regards to atopic dermatitis, IgG has been shown to increase the levels of cutaneous lymphocyte-associated antigen (CLA) that subsequently influences the thymic maturation of certain types of T-cells. Since CLA is known to be a peripheral biomarker of atopic dermatitis, there are possible associations between IgG mediation and certain skin conditions.30 Research has also demonstrated that elimination diets based on IgG-mediated sensitivity has an influence on asthma-like symptoms such as wheezing and rhinitis, as well as rheumatoid arthritis.31,32

Through the gut-brain axis, IgG complexes against food antigens may also play a role in neuroinflammation and associated conditions, including major depression, Parkinson’s disease, Alzheimer’s disease, and epilepsy.33 Dysregulation of metabolic pathways from the central nervous system (like that of the kynurenine pathway for tryptophan metabolism) can lead to the production of neurotoxic metabolites (i.e. quinolinic acid) which plays a part in the progression of neurological

How

disorders.14 Based on the growing evidence of possible associations with many prevalent and major conditions, IgG-mediated food studies are pertinent in many areas of healthcare research, such as neurology and rheumatology.

Despite existing research, further studies are needed to support a causative relationship between IgG against dietary antigens and food hypersensitivity. Contradictory research suggests that certain food-specific IgG responses can have a protective effect against adverse symptoms. For example, some studies suggest a link with crabspecific IgG and eczema, yet an inverse relationship was shown with tomato-specific IgG and rhinitis.34 Evidence is limited, and studies have challenged the association between IgG and gastrointestinal conditions.35 An increase in research pertaining to IgG-mediated food sensitivity could help answer possible correlations with seemingly unrelated conditions.

It should be made clear that the presence of IgG alone could reflect exposure to dietary foods in both symptomatic and asymptomatic patients, as the production of IgG is likely a typical reaction to the immune system’s frequent encounter of those foods.36 For this reason, IgG/C3d immune complex (IC) may be a more sensitive marker in the identification of delayed food hypersensitivity reactions by measuring activation of the complement system (and thus inflammation), in addition to the adaptive immune response.

Materials & Methods

Subjects This prospective intervention study was carried out by Alanber Health Company, Ltd., in Chengdu, China, between the months of November 2021 and May 2023. All participants resided in Chengdu, China, and were existing patients of the Alanber Health Company clinic. Study participants’ ages ranged from 1-68 years old, and 39% were female.

The criteria for inclusion in the study was the presentation of symptoms prior to screening for IgG/C3d-IC against food antigens and additives, as well as full compliance with the 3-month elimination diet protocol and no consumption of dietary supplements. There was no exclusion criteria based on age, gender, or geographical location. The self-reported initial presenting symptoms were categorized based on the body system affected (Table 1). Participants reported symptoms affecting one or more body systems.

The current study aims to evaluate the therapeutic effectiveness of an elimination diet based on the IgG/C3d immune complex (IC) against 176 food antigens.37 To date, the clinical efficacy of an IgG/C3d-based elimination diet has not been evaluated. IgG/C3d-IC as a biomarker of food sensitivity may provide a more sensitive and targeted approach to identifying offending foods that activate not only the adaptive immune system, but also the innate inflammatory immune response.38 These findings may suggest that the eliminations diets based on IgG/C3d-IC are a more effective method of reducing inflammatory symptoms and have significant implications for personalized clinical dietary interventions.

Gastrointestinal symptoms represented the most frequently observed body system affected, followed by dermal, nasal, and neurological symptoms (Table 2). Less frequently reported symptoms included insomnia, musculoskeletal, general fatigue, and weight maintenance. 17% (13) reported “other” symptoms, including sore throat, itchy eyes, halitosis, arrythmia, coughing, asthma, and anxiety.

455 patients were initially screened for food sensitivities, with 39 presenting few or no symptoms and 255 with no record of symptoms (Figure 1). Out of the 161 participants presenting symptoms, 87 were compliant with the 3-month elimination diet protocol. 12 participants were lost to follow up after the elimination diet phase, leaving a total

of 74 participants for inclusion in the study. Informed consent was obtained by all subjects participating in the study, ensuring that subjects understood the purpose, significance, limitations, and risks of the test and diet management intervention.

Figure 1: Total Inclusion of Study Participants

Processing of the bloodspot samples included elution in extraction buffer for 2 hours at 2-8°. Samples were added to pre-coated 96-well ELISA plates and allowed to incubate overnight at 2-8°. The unbound sample was washed off using a wash buffer, and HRP-conjugated secondary antibody was added at working dilution. Unbound secondary antibody was washed off and colorimetric TMB substrate was added. An acid solution was added to halt the enzymatic reaction. Plates were read at 450nm.

Sensitivity to specific foods and additives was determined statistically by comparing reactivities between foods within a given sample. Antigens were graded on a scale of 0 (no reactivity) to 4 (maximum reactivity) based on statistical criteria, with 0 indicating no sensitivity, 1+ indicating low sensitivity, 2-3+ indicating moderate sensitivity, and 4+ indicating maximum sensitivity.

IgG/C3dg Antibody Detection against dietary antigens and additives Each study participant was screened for IgG/ C3dg-IC against a panel of 176 different dietary foods and additives using an enzyme-linked immunosorbent assay (ELISA)16. Sample types collected included dried bloodspots only. Briefly, bloodspot samples were collected using a contact-activated lancet to pierce the fingertip. 5 free-falling drops of capillary blood were dropped onto the filter paper of a 503 Bloodspot Card (Eastern Business Forms; Cat #: 10550021). The blood sample was allowed to dry for several hours at room temperature before shipment at ambient temperature.

Elimination Diet Protocol

For each test, a dietician interpreted the test results and issued a 3-month diet management program to each participant. The diet management program consisted of 2 phases: removal and replacement, followed by re-introduction. Initially, subjects were instructed to remove all foods having sensitivities of 2+, 3+, or 4+ from their diet for a minimum of 6 weeks. During this period, alternative sources of nutrients were included in the diet to avoid nutritional imbalance.

The reintroduction phase involved the reintroduction of 1 eliminated food at a time into the diet, followed by one week of observation where participants noted any changes in their initial symptoms. The concurrent introduction of multiple foods was not recommended. If no recurrent symptoms were observed, the specific food may be included in the diet moving forward. If recurrent symptoms were observed, it is assumed that the participant may have a food sensitivity against the reintroduced food, and the implicated food should be entirely removed from the diet. The reintroduction and observation cycles were repeated for each identified offending food until

How

all foods had been assessed. The diet management program lasted for a minimum of 12 weeks, or total time required to assess all food sensitivities for recurrent symptoms.

Onsite or virtual follow-up visits were conducted for each participant at the conclusion of the diet management program to assess changes in initial presenting symptoms. All changes in symptoms were self-reported and interpreted by the treating dietician. Children’s symptoms were documented and reported to the treating dietician by their caregivers.

Results

Reported Changes in Symptoms Overall, 82.4% of all participants (n = 74) reported an improvement in one or more initial symptoms. Among those initially reporting gastrointestinal symptoms, 41 of the 46 participants (89.1%) experienced a decrease in symptom severity after complying with the elimination diet protocol (Table 3). Participants testified that “symptoms of flatulence, diarrhea, gas, and brain fog improved”, and some experienced “less frequent occurrence of abdominal pain” (translated from Mandarin, Chinese).

Of the 38 participants reporting dermal symptoms, 31 (81.6%) reported a reduction in symptom severity (Table 3). Participants reported improvements in the severity of eczema, acne, pruritis, cheilitis, urticaria, and the general condition of the skin. Of the less frequently reported symptoms including joint pain, insomnia, fatigue, and weight maintenance, 83.3% (5), 75.0% (6), 100.0% (5), and 100.0% (2) reported a decrease in symptom severity, respectively (Table 3).

Discussion

To date, this is the first research to assess how an elimination diet that employs IgG/C3d immune complex (IC) may identify potential delayed hypersensitivities to dietary foods and evaluates an array of inflammatory symptoms, as opposed to a singular condition. Prior studies suggest that IgG-based elimination diets may improve conditions such as migraines and IBS, but this is the first study to evaluate multiple inflammatory symptoms within the same study group using the IgG/C3d-IC biomarker.

General symptoms of inflammation were assessed, and self-reported changes in symptoms demonstrated that the severity of initial symptoms decreased in most patients following the IgG/C3d-based elimination diet. This data is consistent with prior studies, which suggest that IgG based elimination diets may improve symptoms of migraines, IBS, and arthritis. However, our study expands upon prior research by demonstrating that IgG/C3d-IC may serve as a more sensitive and specific biomarker to identify delayed hypersensitivity, as opposed to IgG only. The use of IgG alone against dietary antigens in the identification of food sensitivities is clouded by the potential for elevated serum IgG due to exposure alone.17 For this reason, IgG/ C3d-IC demonstrates a more sensitive marker in the identification of inflammatory foods that may be at the root of inflammatory symptoms.16

These preliminary results support the continued assessment of IgG/C3d-IC as a clinically relevant biomarker for food sensitivity and suggest that elimination diets based on this marker may have clinical utility in reducing inflammatory symptoms. Throughout the sample collection procedure and elimination diet protocol, no adverse reactions were reported, supporting the safe integration of the protocol into clinical practice.

While the results of the current study are promising, they warrant continued evaluation through increasingly rigorous methods. Additionally, the diet protocol was conducted by trained dieticians that facilitated the

implementation and compliance with the elimination diet, which may not mirror “real-world” conditions in which patients do not receive coaching. Future studies should also target geographically diverse populations, which would increase the generalizability of the findings outside of the study population.

Conclusions

In summary, our data provide compelling evidence of the clinical utility of IgG/C3d-IC as a biomarker of delayed

Biography:

food hypersensitivity. Removal of identified dietary antigens from the diet may improve general symptoms of inflammation, suggesting the clinical utility of IgG/C3d-IC diagnostic testing. Further exploration of IgG/C3d-IC as a clinically useful biomarker is essential to expanding its integration into clinical practice, particularly in the sphere of personalized medicine.

Nell Fitzgerald leads in-house manufacturing at KBMO Diagnostics and has worked on the development of KBMO’s Gut Barrier Panel to screen for biomarkers of gut permeability. Jonathan Wright is a member of the manufacturing team at KBMO Diagnostics with a background in mathematics and biology.

Nell Fitzgerald Email: nfitzgerald@kbmodiagnostics.com Phone: 508-713-7812

References:

Jonathan Wright Email: john60468@gmail.com

Phone: 617-933-8130

1. Shakoor Z, Al Faifi A, Al Amro B, AlTawil LN, Al Ohaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016 Nov-Dec;36(6):386-390. doi: 10.5144/0256-4947.2016.386. PMID: 27920409; PMCID: PMC6074204.

2. USDA, food Allergies: The “Big 9”, https://www.fsis.usda.gov/foodsafety/safe-food-handling-and-preparation/food-safety-basics/foodallergies-big-9#:~:text=These%20eight%20foods%20account%20 for,%2C%20peanuts%2C%20wheat%20and%20soybeans., March 21st, 2024

3. qbal, Amjad & Shah, Farooq & Jamal, Yousaf & Hamayun, Muhammad & Islam, Badshah & Hayat, Zafar & Hussain, Anwar & Rehman, Gauhar & Ziaullah, & Shah, Sadiq. (2018). DETECTION OF FOOD ALLERGENS BY ELISA AND OTHER COMMON METHODS. Fresenius Environmental Bulletin. 27. 8340-8346.

4. Abbas M, Moussa M, Akel H. Type I Hypersensitivity Reaction. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32809396

5. Marwa K, Kondamudi NP. Type IV Hypersensitivity Reaction. [Updated 2023 Aug 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www. ncbi.nlm.nih.gov/books/NBK562228/

6. W. T., Godbey, Complement Cascade, Biotechnology and its Applications (Second Addition), https://www.sciencedirect. com/topics/engineering/complement-cascade#:~:text=The%20 complement%20system%20plays%20a,%2C%20and%20 psoriasis%2C%20among%20others., 2022

7. Noris M, Remuzzi G. Overview of complement activation and regulation. Semin Nephrol. 2013 Nov;33(6):479-92. doi: 10.1016/j. semnephrol.2013.08.001. PMID: 24161035; PMCID: PMC3820029.

8. aneway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. The complement system and innate immunity. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK27100/

9. Clarke, Damien, Burdette, Cheryl, Agolli, Gez, Dorval, Brent, Gaston, Antoinette, Chesla, Scott, The Relevance of Using the C3d/ Immunoglobulin G Test in Clinical Intervention, 2022,

10. Toapanta FR, Ross TM. Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity. Immunol Res. 2006;36(1-3):197-210. doi: 10.1385/IR:36:1:197. PMID: 17337780.

11. Rickert, R., Regulation of B Lymphocyte Regulation from C3 and the B cell coreceptor Complex, https://www.sciencedirect.com/ science/article/abs/pii/S0952791505000397, April 8, 2005

12. Carroll MC. The complement system in B cell regulation. Mol Immunol. 2004 Jun;41(2-3):141-6. doi: 10.1016/j. molimm.2004.03.017. PMID: 15159059.

13. Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. B Cells and Antibodies. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK26884/

14. Kearns, R. Gut-Brain Axis and Neuroinflammation: The Role

How

of Gut Permeability and the Kynurenine Pathway in Neurological Disorders, https://link.springer.com/article/10.1007/s10571-02401496-z#:~:text=The%20relationship%20between%20gut%20 permeability,&%20Cryan%202017a%2C%20b, Volume 44, Article 64, 2024

15. Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM. Intestinal permeability--a new target for disease prevention and therapy. BMC Gastroenterol. 2014 Nov 18;14:189. doi: 10.1186/s12876-014-0189-7. PMID: 25407511; PMCID: PMC4253991.

16. Caminero A, Meisel M, Jabri B, Verdu EF. Mechanisms by which gut microorganisms influence food sensitivities. Nat Rev Gastroenterol Hepatol. 2019 Jan;16(1):7-18. doi: 10.1038/s41575-018-0064-z. PMID: 30214038; PMCID: PMC6767923.

17. Fassano, A, Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer, https://journals.physiology.org/doi/full/10.1152/physrev.00003.2008, January 1, 2011

18. Pantoja-Arévalo L, Gesteiro E, Matthias T, Urrialde R, GonzálezGross M. Association between Food-Specific Immunoglobulin G4 Antibodies in Adults with Self-Reported Signs and Symptoms Attributed to Adverse Reactions to Foodstuffs. Biomedicines. 2023

19. Matei DE, Menon M, Alber DG, Smith AM, Nedjat-Shokouhi B, Fasano A, Magill L, Duhlin A, Bitoun S, Gleizes A, Hacein-BeyAbina S, Manson JJ, Rosser EC; ABIRISK Consortium; Klein N, Blair PA, Mauri C. Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease. Med. 2021 Jul 9;2(7):864-883.e9. doi: 10.1016/j.medj.2021.04.013. PMID: 34296202; PMCID: PMC8280953.

20. Vanuytsel T, Tack J, Farre R. The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Front Nutr. 2021 Aug 26;8:717925. doi: 10.3389/fnut.2021.717925. PMID: 34513903; PMCID: PMC842716.

21. “How Sleep Deprivation Can Cause Inflammation.” Harvard Health, 29 Apr. 2024.

22. Wu, M., Wang, X., Sun, L. et al. Associations between food-specific IgG and health outcomes in an asymptomatic physical examination cohort. Nutr Metab (Lond) 19, 22. 2022

23. Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 2004;53(10):1459-1464. doi:10.1136/ gut.2003.037697

24. Guo H, Jiang T, Wang J, Chang Y, Guo H, Zhang W. The Value of Eliminating Foods According to.Food-Specific Immunoglobulin G Antibodies in Irritable Bowel Syndrome with Diarrhoea. Journal of International Medical Research. 2012;40(1):204-210. doi:10.1177/147323001204000121

25. Ostrowska L, Wasiluk D, Lieners CFJ, Gałęcka M, Bartnicka A, Tveiten D. Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS-Results from an Open Label Study. J Clin Med. 2021 Sep 23;10(19):4317. doi: 10.3390/ jcm10194317. PMID: 34640335; PMCID: PMC8509634

26. Xie Y, Zhou G, Xu Y, et al. Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome. Pain Res Manag. 2019;2019:7890461. doi:10.1155/2019/789046

27. Alpay K, Ertaş M, Orhan EK, Üstay DK, Lieners C, Baykan

B. Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomized, cross-over trial. Cephalalgia. 2010;30(7):829-837. doi:10.1177/0333102410361404

28. S. Bentz, M. Hausmann, H. Piberger, S. Kellermeier, S. Paul, L. Held, W. Falk, F. Obermeier, M. Fried, J. Schölmerich, G. Rogler; Clinical Relevance of IgG Antibodies against Food Antigens in Crohn’s Disease: A Double-Blind Cross-Over Diet Intervention Study. Digestion 1 April 2010; 81 (4): 252–264. https://doi. org/10.1159/000264649

29. Uzunısmaıl H, Cengız M, Uzun H, Ozbakir F, Göksel S, Demırdağ F, Can G, Balci H. The effects of provocation by foods with raised IgG antibodies and additives on the course of Crohn’s disease: a pilot study. Turk J Gastroenterol. 2012 Feb;23(1):19-27. doi: 10.4318/ tjg.2012.0332. PMID: 22505375.

30. de Sousa TR, Fagundes BO, Nascimento A, Fernandes LA, Sgnotto FDR, Orfali RL, Aoki V, Duarte AJDS, Sanabani SS, Victor JR. IgG from Adult Atopic Dermatitis (AD) Patients Induces Thymic IL-22 Production and CLA Expression on CD4+ T Cells: Possible Epigenetic Implications Mediated by miRNA. Int J Mol Sci. 2022 Jun 20;23(12):6867. doi: 10.3390/ijms23126867. PMID: 35743308; PMCID: PMC9224968.

31. Shaw W., Clinical Usefulness of IgG Food Allergy, March 26, 2023, https://mosaicdx.com/resource/clinical-usefulness-of-igg-foodallergy-testing/

32. Gamlin L., Brostoff J, Food Sensitivity and Rheumatoid Arthritis, Environmental Toxicology and Pharmacology Vol. 4, Issues 1-2, pgs.43-49, 1997, https://www.sciencedirect.com/science/article/abs/ pii/S1382668997100400

33. Tao R, Fu Z, Xiao L. Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder. Genomics Proteomics Bioinformatics. 2019 Apr;17(2):183-189. doi: 10.1016/j.gpb.2019.05.002. Epub 2019 Jun 21. PMID: 31233833; PMCID: PMC6620418.

34. Zeng Q, Dong SY, Wu LX, Li H, Sun ZJ, Li JB, Jiang HX, Chen ZH, Wang QB, Chen WW. Variable food-specific IgG antibody levels in healthy and symptomatic Chinese adults. PLoS One. 2013;8(1):e53612. doi: 10.1371/journal.pone.0053612. Epub 2013 Jan 3. PMID: 23301096; PMCID: PMC3536737.

35. Capobianco I, Di Vincenzo F, Puca P, Becherucci G, Mentella MC, Petito V, Scaldaferri F. Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives. Nutrients. 2024 Jan 25;16(3):351. doi: 10.3390/nu16030351. PMID: 38337636; PMCID: PMC10857040.

36. The Myth of IgG Food Testing, https://www.aaaai.org/tools-for-thepublic/conditions-library/allergies/igg-food-test#:~:text=The%20 presence%20of%20IgG%20is,a%20specialist%20close%20 to%20home.&text=At%20home%20testing%20for%20food%20 intolerance.&text=If%20playback%20doesn’t%20begin%20 shortly%2C%20try%20restarting%20your%20device., January 10, 2024

37. Dorval B, Dantini DC. Detection of Antigen Specific Immunocomplexes. 2012;(US 8,309,318 B2).

38. Kruszewski J, Raczka A, Kłos M, Wiktor-Jedrzejczak W. High serum levels of allergen specific IgG-4 (asIgG-4) for common food allergens in healthy blood donors. Arch Immunol Ther Exp (Warsz). 1994;42(4):259-261.

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• Collagen and elastin synthesis

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seca Body Composition

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The Role of Body Composition Assessment in Improving Health and Longevity Outcomes

By: Nina Crowley, PhD, RD

Director of Clinical Education/Partnerships with seca

Introduction

Aging is an inevitable process that impacts metabolic health, muscle function, and fat distribution. Traditional weight-centric approaches to health assessment, particularly the reliance on Body Mass Index (BMI), fail to capture the complexities of body composition changes that occur with aging.¹ While BMI can be used for screening and population estimates, its limitations in distinguishing between fat mass and lean body mass make it inadequate for

evaluating an individuals’ metabolic health, physical function, and disease risk.²

As interest in longevity and metabolic resilience grows, Body Composition Analysis (BCA) is emerging as an essential tool in anti-aging medicine. By differentiating between skeletal muscle mass, visceral adipose tissue (VAT), and body fat percentage, BCA allows for more precise risk stratification and treatment

The Role of Body Composition Assessment in Improving Health and Longevity Outcomes

planning.³ Unlike BMI, which does not account for agerelated muscle loss (sarcopenia) or shifts in fat distribution, BCA provides quantitative insights into muscle quality, fat accumulation, and hydration status, enabling clinicians to implement targeted, data-driven interventions.⁴

This article explores the limitations of BMI in aging populations, the clinical importance of body composition metrics for longevity, metabolic health, and functional independence, and the role of BCA in optimizing hormonal interventions, including testosterone replacement therapy (TRT) and hormone replacement therapy (HRT).

The Limitations of BMI in Aging Populations

For decades, BMI has served as a standard metric for classifying individuals into weight categories based on height and weight. However, BMI does not distinguish between adipose and lean body mass, making it an unreliable measure of metabolic health.⁵ Studies have demonstrated that individuals with similar BMI values may have vastly different body compositions, with varying degrees of muscle mass, visceral fat, and overall metabolic risk.⁶

Furthermore, BMI fails to account for sarcopenia, the age-related loss of skeletal muscle, which contributes to frailty, insulin resistance, and functional decline.⁷ Research suggests that individuals with normal-range BMI but low muscle mass (sarcopenic obesity) face higher mortality risks than those classified as overweight with preserved muscle mass.⁸ Additionally, BMI does not provide insights into fat distribution, an important factor in cardiovascular risk and metabolic disease.⁹ Visceral adipose tissue (VAT), rather than overall fat mass, is more strongly associated with insulin resistance, inflammation, and cardiometabolic disease, yet BMI lacks the specificity to differentiate VAT from subcutaneous fat.¹⁰

Given these limitations, reliance on BMI alone may lead to misclassification of metabolic risk in aging populations, reinforcing the need for BCA in clinical practice.

The Role of Body Composition in Longevity and Metabolic Health

Muscle mass is a strong predictor of longevity and functional independence in older adults. Studies have shown that greater skeletal muscle mass correlates with improved glucose metabolism, reduced inflammatory markers, and lower risk of frailty and disability.¹¹ Conversely, low muscle mass and excessive visceral adiposity are associated with metabolic dysfunction, increased fall risk, and higher mortality.¹²

Visceral fat accumulation, in particular, is a hallmark of metabolic aging. VAT secretes pro-inflammatory cytokines, contributing to chronic low-grade inflammation, insulin resistance, and endothelial dysfunction, which accelerate the aging process.¹³ Research indicates that VAT is a stronger predictor of cardiovascular disease, type 2 diabetes, and allcause mortality than BMI or total fat mass.¹⁴

BCA enables clinicians to assess visceral adipose tissue, offering a more comprehensive picture of metabolic health. By tracking changes in skeletal muscle mass and VAT over time, providers can tailor interventions to preserve muscle mass, optimize metabolic function, and mitigate the risks associated with visceral adiposity.

Preventing Sarcopenia and Functional Decline

Sarcopenia is a primary contributor to frailty and disability in older adults and has been recognized as a major public health concern.¹⁵ The progressive decline in skeletal muscle mass and strength that accompanies aging is associated with higher rates of falls, fractures, loss of mobility, and premature mortality.¹⁶ Moreover, muscle loss has significant metabolic consequences, as skeletal muscle is the primary site of glucose disposal.¹⁷ Declines in muscle mass contribute to impaired insulin sensitivity, increased adiposity, and heightened inflammation, compounding the risk for metabolic syndrome and cardiovascular disease.¹⁸

Weight loss interventions that fail to account for muscle preservation may exacerbate sarcopenia, worsening overall health outcomes.¹⁹ Traditional caloric restriction without concurrent resistance training and adequate protein intake can result in loss of lean mass, decreased strength, and metabolic slowing.²⁰

BCA provides quantitative assessment of skeletal muscle mass, allowing for early detection of muscle deterioration and the implementation of targeted interventions. Clinicians can tailor resistance training protocols, optimize protein intake, and, when necessary, implement hormonal interventions to maintain muscle function and prevent disability.

As BCA provides a quantitative measure of lean mass, it also serves as an essential tool for assessing the impact of hormone-related interventions, particularly testosterone replacement therapy (TRT) and hormone replacement therapy (HRT). A growing body of evidence suggests that muscle loss and fat redistribution seen with aging can be mitigated with hormonal support, further emphasizing the need for precision-driven interventions.

The Utility of Body Composition Analysis in Hormone Management

Testosterone Replacement Therapy (TRT) and Body Composition

Testosterone plays a critical role in maintaining lean body mass, muscle strength, and fat distribution.²¹ With aging, testosterone levels decline, leading to muscle atrophy, increased visceral adiposity, and reduced metabolic efficiency.²² Hypogonadal men are more likely to experience sarcopenia, insulin resistance, and increased VAT accumulation, placing them at higher risk for cardiometabolic diseases.²³

Testosterone replacement therapy (TRT) has been shown to increase lean muscle mass, reduce VAT, and improve insulin sensitivity in hypogonadal men.²⁴ However, response to TRT varies based on baseline body composition, activity level, and concurrent metabolic conditions.²⁵

BCA serves as a valuable tool in monitoring TRT outcomes, allowing clinicians to: assess baseline muscle mass and fat distribution before initiating TRT, track improvements in lean mass and VAT reduction over time, and identify nonresponders and adjust therapy accordingly. Incorporating BCA-guided assessment into TRT protocols ensures more precise, individualized therapy, optimizing both muscular and metabolic benefits.

Hormone Replacement Therapy (HRT) and Fat Distribution

Women throughout the menopause transition frequently experience shifts in fat distribution, characterized by increased VAT and decreased lean mass.²⁶ Estrogen plays a key role in regulating fat metabolism, and its decline during menopause contributes to redistribution of fat toward the abdomen, increasing metabolic risk.²⁷

Hormone replacement therapy (HRT) has been shown to attenuate VAT accumulation and improve metabolic markers in postmenopausal women.²⁸ However, the effects of HRT on muscle mass and overall body composition vary among individuals, necessitating objective tracking.²⁹

BCA provides clinicians with a quantitative measure of HRT-induced changes in body composition, allowing for better assessment of therapy effectiveness and adjustments based on individual response.

Conclusion

As anti-aging medicine focuses on a precision-based approach, reliance on BMI as a singular health metric is becoming increasingly outdated. BCA offers a superior method for evaluating muscle mass, fat distribution, and metabolic health, providing clinicians with the objective data necessary to implement personalized, evidence-based interventions.

Through early detection of sarcopenia, targeted metabolic interventions, and hormone therapy optimization, BCA serves as a cornerstone in the advancement of longevity medicine. By integrating body composition metrics into routine assessments, healthcare providers can move beyond traditional weight-based models, fostering longer, healthier, and functionally independent aging trajectories.

The Role of Body Composition Assessment in Improving Health and Longevity Outcomes

Author Biography:

Dr. Nina Crowley, PhD, RD, Director of Clinical Education/Partnerships with seca, is a leader in body composition analysis education. A dietitian and health psychologist, she brings over two decades of experience in the metabolic health and obesity care field.

For inquiries, contact:

Dr. Nina Crowley, PhD, RD, Director of Clinical Education and Partnerships at seca North America nina.crowley@seca.com

References:

1. Bosy-Westphal A, Müller MJ. Quantification of visceral fat and abdominal obesity by magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. 2013;37(5):1225-1238.

2. Kyle UG, Bosaeus I, De Lorenzo AD, et al. Bioelectrical impedance analysis— part I: review of principles and methods. Clin Nutr. 2004;23(5):1226-1243.

3. Deurenberg P, Yap M, van Staveren WA. Body mass index and percent body fat: a meta-analysis among different ethnic groups. Int J Obes Relat Metab Disord. 1998;22(12):1164-1171.

4. Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med. 2017;376(3):254-266.

5. Wang Z, Deurenberg P, Wang W, Pietrobelli A, Baumgartner RN, Heymsfield SB. Hydration of fat-free body mass: review and critique of a classic bodycomposition constant. Am J Clin Nutr. 1999;69(5):833-841.

6. Lavie CJ, De Schutter A, Patel DA, Artham SM, Milani RV. Body composition and heart failure prognosis: getting to the fat of the matter in the ‘obesity paradox’. Mayo Clin Proc. 2010;85(7):605-608.

7. Bosy-Westphal A, Müller MJ. Impact of intra- and extra-organ fat on cardiometabolic diseases. Int J Obes (Lond). 2017;41(5):887-894.

8. Cauley JA, Lui LY, Ensrud KE, et al. Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA. 2005;293(17):2102-2108.

9. Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly. J Am Geriatr Soc. 1998;46(8):982-988.

10. Stenholm S, Harris TB, Rantanen T, et al. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care. 2008;11(6):693-700.

11. Heymsfield SB, Smith SR, Redman LM, et al. Energy intake and weight-loss maintenance. Am J Clin Nutr. 2016;104(4):852-860.

12. Roubenoff R. Sarcopenia: effects on body composition and function. J Gerontol A Biol Sci Med Sci. 2003;58(11):1012-1017.

13. Scott D, Johansson J, McMillan LB, et al. Midlife muscle mass and risk of frailty in older adults. Age Ageing. 2021;50(2):409-416.

14. Bouchard DR, Janssen I. Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci. 2010;65(1):71-77.

15. Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard BMI categories. JAMA. 2013;309(1):71-82.

16. Maltais ML, Desroches J, Dionne IJ. Changes in muscle mass and strength after weight loss in obese older adults: a systematic review. Obes Rev. 2009;10(4):366-376.

17. Sinclair M, Grossmann M, Gow PJ, Angus PW. Testosterone in men with advanced liver disease: abnormalities and implications. J Gastroenterol Hepatol. 2015;30(2):244-251.

18. Borst SE, Yarrow JF, Fernandez C, et al. Testosterone administration induces molecular programming augmenting physiological adaptations to resistance exercise training in older men. J Gerontol A Biol Sci Med Sci. 2015;70(9):1160-1167.

19. Giannoulis MG, Martin FC, Nair KS, et al. Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev. 2012;33(3):314-377.

20. Stout M, Tew GA, Doll H, et al. Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study. Am Heart J. 2012;164(6):893-901.

21. Behre HM, Tammela TL, Arver S, et al. A randomized, double-blind, placebo-controlled study of testosterone replacement therapy in men with hypogonadal to low normal levels of testosterone and symptoms of testosterone deficiency: the EARTH study. Eur J Endocrinol. 2012;166(4):675685.

22. Gianatti EJ, Dupuis P, Hoermann R, et al. Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: a randomized controlled trial. Diabetes Care. 2014;37(8):2098-2107.

23. Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care. 2000;23(4):490-

24. Allan CA, Strauss BJ, Burger HG, Forbes EA, McLachlan RI. Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. J Clin Endocrinol Metab. 2008;93(1):139-146.

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25. Maseroli E, Comeglio P, Corno C, et al. Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men. J Endocrinol Invest. 2021;44(4):723-740. �cite�turn0search2�

26. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003;88(6):2404-2411.

27. D’Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem. 2005;280(43):35983-35991.

28. Haarbo J, Marslew U, Gotfredsen A, Christiansen C. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism. 1991;40(12):1323-1326.

29. Gambacciani M, Ciaponi M, Cappagli B, et al. Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women. J Clin Endocrinol Metab. 1997;82(2):414-417.

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The Science of Telomerase Activation

PROVEN telomerase activator for safe telomere lengthening

ULTIMATE senolytic: -21% Senescent T cells, +12% Naïve T cells

VERIFIED by 10+ peer-reviewed, published studies

Renewed Focus on Telomere Biology as a Primary Driver of Aging: What’s TERT

Got to Do with It?

By: Joseph M. Raffaele, MD

Abstract

Recent discoveries in telomere biology have sparked renewed interest in leveraging telomerase reverse transcriptase (TERT) to address the underlying mechanisms of aging. Telomeres, which cap and protect the ends of chromosomes, shorten with each cell division and are influenced by oxidative stress. Telomerase, particularly its catalytic subunit TERT (also called hTERT in humans), can lengthen

telomeres in certain cell types and has been shown in animal models to reverse some phenotypes of aging. Recent studies highlight that TERT’s “noncanonical” activities—which include mitochondrial protection, regulation of reactive oxygen species (ROS), and epigenetic modulation—may be as critical as its canonical telomere-lengthening function. This article reviews the fundamentals

Renewed Focus on Telomere Biology as a Primary Driver of Aging: What’s TERT Got to Do with It?

of telomere biology, the role of TERT in aging, and the emerging data on small-molecule telomerase activators with the potential to mitigate age-related decline.

Introduction

Aging is a multifactorial process characterized by cumulative cellular damage, genomic instability, and a gradual decline in the body’s ability to repair and renew tissues. Among the diverse mechanisms that drive aging, telomere attrition has received significant attention since Leonard Hayflick’s pioneering work in 1961 revealed that human somatic cells possess a finite replicative lifespan.¹

Telomeres are repeated DNA sequences (TTAGGG) that protect chromosome ends. Telomeres shorten progressively with each cell division, eventually triggering cellular senescence or apoptosis.

Telomerase is the ribonucleoprotein enzyme complex primarily responsible for maintaining telomere length. In adult humans, telomerase activity is significantly repressed in most somatic tissues. However, it remains active in stem cells, germline cells, and certain highly proliferative tissues. Telomerase consists of two main subunits:

• Telomerase reverse transcriptase (TERT): the enzyme that adds new DNA repeats to the ends of chromosomes.

• Telomerase RNA component (TERC): the RNA blueprint for creating those repeats.

The following section examines how TERT may mitigate a broad range of aging mechanisms, not only by lengthening telomeres but also by modulating epigenetic regulation, cellular metabolism, and mitochondrial function. Evidence from rodent models and in vitro studies suggests that small-molecule telomerase activators can partially restore TERT function in aging tissues. These results pave the way for new therapies designed to extend and improve healthy human lifespans.

Telomeres and the Hayflick Limit

In his seminal work, Leonard Hayflick demonstrated

that human fibroblasts in culture have a finite replicative capacity—generally around 60 population doublings—before entering senescence.¹ Further studies show that telomeres serve as the “molecular clock” behind this limit. Telomeres shorten with each round of cell division, primarily due to:

• End-Replication Problem: DNA polymerase cannot fully replicate the 3’ end of linear chromosomes.

• Oxidative Stress: Telomeric DNA, particularly the guanine-rich G-strand, is highly susceptible to ROS.

• Stem Cell Turnover: Tissues with high proliferative demands (e.g., bone marrow, gut epithelium) experience accelerated telomere shortening if telomerase is insufficiently active.

In humans, telomere length ranges between 8 to 13 kilobases (kb) at birth and gradually decreases with age. Critically short telomeres of around 4 to 5 kb often signal cellular senescence or apoptosis, contributing to tissue dysfunction and association with numerous age-related diseases.²

Telomerase: TERT and TERC

Canonical Function

Telomerase is composed of two main subunits: TERT (telomerase reverse transcriptase) and TERC (telomerase RNA component). During embryonic development, telomerase is highly active, but in most adult somatic cells, TERT is repressed. A partial reactivation of telomerase in adult life can help maintain telomeres in specific tissues, such as hematopoietic stem cells. However, overall telomerase levels in most adult cells remain insufficient to prevent telomere erosion entirely. This insufficiency is further compounded by natural declines in telomerase activity, estimated at around 50% by middle age.

Non-Canonical Functions

Beyond its canonical role in telomere maintenance, TERT has been implicated in an array of “non-canonical” functions, including:

• Mitochondrial Protection and Metabolism:

TERT may translocate to mitochondria, reducing oxidative damage to mitochondrial DNA and improving cellular stress resistance.

• Epigenetic Regulation: TERT can influence DNA methylation patterns by modulating enzymes such as DNMT3b, thereby affecting gene expression and cell fate.

• Stress Response and Senescence: TERT appears capable of repressing or delaying cellular senescence markers like p16.

These additional functions suggest that turning telomerase back on in certain situations could help slow down aging throughout the body, not just by lengthening telomeres.

Lessons from Telomerase Knockout and Reactivation Mouse Models

Telomerase Knockout Models

Laboratory mice naturally have very long telomeres (50–70 kb), which can make them less representative of human aging. Researchers overcame this by creating telomerase knockout (KO) mice lacking TERC.³ After several generations, these KO mice developed significantly shorter telomeres, leading to premature aging phenotypes in tissues with high turnover (e.g., bone marrow, gut epithelium). Additional features included a progressive decrease in median lifespan and exacerbated degenerative pathologies over successive generations.

Reactivation and Age Reversal

In another groundbreaking study, researchers activated TERT in telomerase-deficient mice, showing that telomerase reactivation reversed multiple aging issues— including testicular atrophy, splenic atrophy, and neuronal decline.⁴ Similarly, gene therapy with viral vectors expressing TERT has demonstrated improvements in insulin sensitivity, osteoporosis, and neuromuscular coordination in normal aging mice.⁵ Remarkably, increasing TERT activity in these 1- and 2-year-old mice prolonged their median lifespan by 24 and 13%, respectively.

These findings highlight the possibility that restoring TERT activity to youthful levels may improve or even

reverse specific age-related pathologies in mammals.

TERT and the Hallmarks of Aging

The “Hallmarks of Aging” describes nine interconnected mechanisms—such as genomic instability, stem cell exhaustion, and altered intercellular communication— that collectively drive the aging process.⁶ TERT appears to intersect with many of these hallmarks:

• Genomic Instability: By maintaining telomeres and protecting chromosome ends, TERT reduces the DNA damage response that triggers cell senescence.

• Cellular Senescence: TERT can repress p16 and other senescence markers, mitigating the accumulation of senescent cells.

• Epigenetic Alterations: Through interactions with epigenetic regulators, TERT influences chromatin structure and gene expression, potentially reprogramming cells toward a more youthful state.

• Mitochondrial Dysfunction: TERT’s role in maintaining mitochondrial health extends its protective effects beyond the nucleus.

Ongoing research indicates that modest TERT reactivation can significantly mitigate aging by stabilizing the genome, reducing inflammation, and supporting stem cell function.

Small-Molecule Telomerase Activation

Telomerase Activating Compound (TAC) in Rodents

A screening of more than 650,000 compounds led to the discovery of several Telomerase Activating Compounds (TAC). In mouse models, one such compound demonstrated an approximately 40% increase in telomere length and a 50–90% reduction in the senescence marker p16. Short-term TAC treatment improved hippocampal gene expression related to neurogenesis, while longer-term administration in older mice enhanced cognition and neuromuscular function.7 While these preclinical results are promising, TAC safety and efficacy in humans remain unknown. The compound was administered intraperitoneally, which may limit direct translation to oral or other more patient-

Renewed Focus on Telomere Biology as a Primary Driver of Aging: What’s TERT Got to Do with It?

friendly administration routes. Rigorous toxicology studies and clinical trials are necessary to evaluate TAC’s potential in human longevity interventions.

Human-Applicable Approaches

Researchers are focusing on controlled, short-term telomerase activation. Although some plant extracts and synthetic compounds show promise in laboratory tests, extensive, well-designed clinical trials are still needed to verify their safety and effectiveness in humans.

TA-65: A Proven Commercially Available Telomerase Activation Product

TA-65 is a patented, all-natural, plant-based compound that can help maintain or rebuild telomeres that diminish as people get older. It has been shown to transiently activate telomerase and is formulated as a 99% pure extract.

• In telomeric repeat amplification protocol (TRAP) assays, TA-65 produces about a 3-fold increase in telomerase activity at 0.1 mcMol, making it a moderate telomerase activator in neonatal foreskin keratinocytes and fetal lung fibroblasts.

• Serum levels in humans reach the middle concentration range after a single dose, suggesting it could be relevant for clinical applications.

• TA-65 was one of the earliest telomeraseactivating molecules to undergo extensive study and is often considered the “gold standard” in the field. Over 12 published studies, including double-blind, placebo-controlled trials, have investigated TA-65’s impact on immune function, metabolic health, and other markers of aging.

Key Double-Blind, PlaceboControlled TA-65 Studies

• Immune Senescence in Healthy Adults

• A randomized, double-blind, placebo-controlled clinical trial with 500 healthy volunteers demonstrated that daily intake of TA-65 significantly decreased senescent T cells (CD8+CD28-) compared to placebo. Subjects

taking TA-65 saw meaningful improvements in immune markers with no product-related toxicity or serious adverse events.8,9

• TACTIC Trial in Post-Myocardial Infarction (MI) Patients

• The TACTIC trial (phase IIa, single-center, parallel-group) enrolled 90 participants aged 65+ who had experienced an MI within the previous six months. Participants received 8 mg doses of TA-65 or placebo twice daily for 12 months.

• Key findings included:

• Significant increases in total lymphocyte counts, particularly CD3+, CD4+, CD8+ T-lymphocytes, B-lymphocytes, and NK cells.

• A 62% reduction in the inflammatory marker hsCRP compared to placebo.

• Fewer post-MI complications (e.g., chest or joint pain) and a 30% lower incidence of adverse events in the TA-65 group.

• These results suggest that telomerase activation and improved mitochondrial function may combat immunosenescence and chronic inflammation after MI, potentially aiding in recovery and long-term cardiovascular health.9

Current Clinical Implications and Future Directions

Although telomerase-activating therapies in humans remain in early stages, partially restoring TERT to youthful levels is a compelling concept. Future clinical goals include:

• Reducing Cellular Senescence: By lengthening critically short telomeres, TERT reactivation may decrease the burden of senescent cells linked to chronic inflammation (inflammaging).

• Enhancing Tissue Regeneration: Key tissues, including the hematopoietic system, skin, and nervous system, may benefit from mild, targeted increases in telomerase.

• Improving Metabolic and Mitochondrial Health: TERT’s non-canonical roles in mitochondrial function may help improve insulin sensitivity and reduce oxidative damage.

With TA-65 already on the market, individuals seeking a telomerase-activating approach have an option supported by multiple studies. Nonetheless, continued research in this area will help confirm optimal dosing and which populations might benefit the most—particularly among those recovering from conditions like myocardial infarction.

Conclusion

Telomere biology is once again drawing major attention in anti-aging medicine, with TERT now seen as central to maintaining or renewing healthy cell function. Evidence from animal models demonstrates that moderate

Author Biography:

telomerase activation can reverse various aging-related pathologies, suggesting broad therapeutic potential.

Additionally, TA-65—a patented telomerase-activating extract—has emerged as a practical, scientifically backed tool for those looking to support healthy aging now. By bridging research findings and clinical practice, TA-65 illustrates how telomerase-targeted interventions might help individuals extend both lifespan and healthspan. Going forward, further studies will determine precisely how measured increases in telomerase activity can slow, halt, or partially reverse the aging process without increasing risk, reinforcing telomerase reactivation as a vital research frontier.

Joseph M. Raffaele, MD has practiced longevity medicine for 25 years, publishing studies on telomere biology, epigenetics, hormone therapy, and glycobiology. He is CEO/CMO of PhysioAge Health Analytics and writes at RaffaeleMedical.com.

Contact: jmr@raffaelemedical.com.

References:

1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614-636.

2. Victorelli S, Passos JF. Telomeres and cell senescence: size matters not. EBioMedicine. 2017;21:14-20. doi:10.1016/j.ebiom.2017.03.027. PMCID: PMC5514392. PMID: 28347656.

3. Donate LE, Blasco MA. Telomeres in cancer and ageing. Philos Trans R Soc Lond B Biol Sci.2011;366(1561):76.

4. Jaskelioff M, Muller FL, Paik JH, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011;469(7328):102-106.

5. Bernardes de Jesus B, Vera E, Schneeberger K, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012;4(8):691-704. doi:10.1002/emmm.201200245. PMCID: PMC3494070. PMID: 22585399.

6. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-1217.

7. Shim HS, Iaconelli J, Shang X, et al. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024 Jul 25;187(15):4030-4042.e13. doi:10.1016/j.cell.2024.05.048. PMCID: PMC11552617; PMID: 38908367.

8. Singaravelu G, Harley CB, Raffaele JM, Sudhakaran P, Suram A. Double-blind, placebo-controlled, randomized clinical trial demonstrates telomerase activator TA-65® decreases immunosenescent CD8+CD28- T cells in humans. Unpublished Data / T.A. Sciences Inc.

9. Bawamia B, Spray L, Wangsaputra VK, et al. TA-65 in myocardial infarction (TACTIC Trial). GeroScience.2023.

Mesenchymal Stem Cells

Unlocking the Potential of Regenerative Medicine

Join us for this non-CME afternoon presentation!

When: Friday, April 25th at 3:30 PM

Location: Ballroom B

Key Highlights:

A presentation by Dr Mattias Bernow, CEO of Swedish stem cell producer Cellcolabs

This presentation provides an in-depth look at the transformative potential of Mesenchymal Stem Cells (MSCs) in regenerative medicine.

1. Gain Insights into Good Manufacturing Practices (GMP) and Quality Assurance in Mesenchymal Stem Cell (MSC) Production

2. Differentiate Between MSC Sources and Treatment Approaches (allogeneic vs autologous)

3. Gain insight into the extensive research demonstrating the safety, versatility, and regenerative capabilities of MSCs across various medical indications

4. Learn about Cellcolabs Clinical’s patient-funded clinical trials in the Bahamas, focusing on cardiovascular disease prevention, musculoskeletal degeneration and aging frailty

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Don’t Let Your Doctor Kill You: The Ultimate Patient Playbook for Navigating Modern Healthcare

By: Erika Schwartz, MD

Introduction

In today’s complex healthcare landscape, where do you turn when the system designed to heal you seems more likely to harm you? Dr. Erika Schwartz’s updated bestseller, “Don’t Let Your Doctor Kill You,” offers a desperately needed roadmap for patients navigating a broken healthcare system.

From traditional doctor arrogance to a new era of questionable social media health influencers, Dr. Schwartz’s book is more relevant than ever. As healthcare costs continue to rise

while patient outcomes decline, Americans are increasingly caught between a system that views them as profit centers and self-proclaimed experts pushing unproven remedies online.

The Perfect Patient: A Dangerous Myth

Dr. Schwartz begins by introducing us to Ruth, a fifty-two-year-old woman experiencing fatigue and abdominal discomfort. After rushed appointments with specialists, Ruth finds herself being pushed toward a hysterectomy by a gynecologist who barely makes eye contact with her. In just minutes,

this doctor decides to remove her reproductive organs with minimal explanation or discussion of alternatives.

This scenario plays out countless times daily across America. Patients like Ruth become “perfect patients”— deferential, unquestioning, and compliant—out of fear and conditioning. They accept whatever their doctors say, even when their intuition suggests otherwise.

Consider Emily’s heartbreaking story. Her decades of blind obedience to doctors culminated in tragedy. Diagnosed with Stage IV breast cancer after years of treatments for benign lumps, Emily endured thirteen months of grueling chemotherapy without questioning her oncologist—even when he assured her she would “be around for years” despite her terminal condition. Ten days before her death, the hospital attempted to transfer her to a rehabilitation facility—not for her benefit, but to avoid having a death on their statistical record. Emily’s final word was her doctor’s name, still hoping for help that would never come.

These aren’t isolated incidents. They’re symptoms of a systemic disease plaguing American healthcare.

How We Got Here: From House Calls to Healthcare Inc.

Dr. Schwartz traces how American medicine transformed from a healing profession to a profit-driven industry. She contrasts today’s impersonal assembly-line care with the era of house calls, when doctors knew their patients as whole people, not collections of symptoms and billing codes.

“Before World War II, 40 percent of all doctor visits occurred in the home,” she writes. “The house-call doctors of old had a huge advantage that’s lost on today’s medical professionals: They knew how to listen to their patients and care for them as complete human beings, not just a collection of organs and diseases.”

What changed? Dr. Schwartz identifies several key factors:

1. The rise of specialization: As medicine became increasingly specialized, doctors focused on narrower aspects of health, losing sight of the whole patient.

2. Money-driven incentives: From pharmaceutical companies to insurance providers, profit motives have corrupted medical decision-making.

3. Medical training: Today’s physicians undergo a form of indoctrination that transforms idealistic students into jaded practitioners who view patients as revenue sources rather than human beings.

4. Disease-centered care: Modern medicine focuses on finding and treating disease rather than promoting health, creating a perpetual cycle of testing, diagnosis, and treatment.

One particularly striking example is Dr. G, a renowned cardiac surgeon who saved Rosie’s heart but treated her and her family with cold indifference. While technically brilliant, Dr. G exemplifies how modern medicine has mastered saving organs while forgetting the humans they belong to.

The Rise of Social Media Medicine

In this updated edition, Dr. Schwartz addresses a troubling new development: the explosion of health information and misinformation on social media.

“Since the first publication of Don’t Let Your Doctor Kill You, much has changed in the world,” she writes. “COVID, AI, and politics have brought about a huge shift in the way the public is involved in healthcare. Unfortunately, not much has improved the way doctors treat patients, and sadly an even more troublesome trend has emerged: the rise of biohackers, influencers, and longevity gurus who have free reign on social media.”

The aftermath of COVID has created an entirely new challenge for patients. The pandemic not only exposed the fragility of our healthcare system but unleashed a tsunami of self-proclaimed experts offering untested solutions. From “wellness influencers” with millions of followers to celebrity doctors who rarely practice medicine anymore, these new authorities often prioritize engagement and supplement sales over evidence-based advice.

Dr. Schwartz warns that while traditional doctors may

not know best, “a social media influencer probably knows even less.” She explores how both systems— traditional medicine and influencer culture—share disturbing similarities: exploiting fear, prioritizing profit over people, and making promises they can’t keep.

The GLP-1 weight loss drug saga illustrates this problem. While patients struggle with legitimate health conditions, pharmaceutical giants have seen their stock prices soar selling thousand-dollar medications. When shortages made these drugs unavailable, patients found affordable alternatives through compounding pharmacies—only to have the FDA abruptly declare the shortage “over” and crack down on these options.

This isn’t about patient safety; it’s about protecting pharmaceutical profits. These companies push unit dose packages specifically designed to put compounding pharmacies out of business. Their onesize-fits-all dosing is typically too high and lacks the personalization that compounding provides.

The Insurance Trap

Perhaps nowhere is the system’s dysfunction more evident than in the insurance industry. What began as a way to protect patients has morphed into a labyrinthine system that often blocks care while extracting maximum profit.

Dr. Schwartz shares the story of Lauren, whose comprehensive insurance coverage became a ticket to an endless carousel of specialists, tests, and procedures. After complaining of fatigue, Lauren entered a medical gauntlet that included blood tests, CT scans, MRIs, a bone marrow biopsy, and consultations with over twenty specialists—yet no one addressed her original complaint or coordinated her care.

“Once an insurance company is willing to pay for a system run amok,” Dr. Schwartz writes, “you are at risk of being broken down into millions of tiny little pieces, each with individual labels, without a clear treatment plan and absolutely no perspective or interest in improving your quality of life. It’s like donating your body to science while you’re still alive.”

She also reveals how the “game of documentation” has corrupted medical care. Doctors have learned to manipulate diagnosis codes to extract maximum payment from insurers, turning patients into collections of billable conditions rather than people needing help.

Victoria Reggio shares another heartbreaking example: her sister Emily faithfully paid premiums on a long-term care insurance policy for twenty years, only to have the insurer drag its feet when she needed coverage during her terminal illness. The company finally approved her claim—three days after she died. Emily had paid more than $100,000 in premiums but never received a penny of benefit.

Becoming an Empowered Patient

The brilliance of Dr. Schwartz’s book lies not just in identifying problems but in providing solutions. She offers practical guidance for transforming yourself from a “perfect patient” into an “empowered patient” who can navigate both traditional medicine and newer health information sources.

When evaluating any health advice, Dr. Schwartz recommends asking yourself:

• Who benefits financially from my following this advice?

• What evidence supports this claim beyond personal testimonials?

• What are the risks as well as the potential benefits?

• Is the person advising me willing to acknowledge the limitations of their approach?

• Does this advice acknowledge my unique situation or is it a one-size-fits-all solution?

She challenges readers to question assumptions, seek evidence, understand motivations, and remember that your body is uniquely yours. Both medical arrogance and influencer overconfidence can be dangerous, she warns. The path to optimal health often lies somewhere in between—taking what’s valuable from both conventional and alternative approaches while avoiding the pitfalls of each.

Don’t Let Your Doctor Kill You: The Ultimate Patient Playbook for Navigating

Dr. Schwartz shares her own journey as a physician who chose a different path. After watching colleagues prioritize procedures and profits over patients, she made a conscious decision to practice medicine differently—removing her white coat to eliminate barriers with patients, making house calls, and focusing on prevention rather than disease.

“I shed my white coat,” she writes. “I felt it did less to keep me from getting blood or other body secretions on my clothes, than it did to create distance between my patients and me. It made me appear different from them, the mighty doctor, not their partner in their health care as I wanted to be.”

This approach didn’t win her popularity contests with hospital administrators, who questioned why she admitted so few patients. But it did lead to better outcomes for her patients, who recovered “far better with simple changes like more sleep, exercise, dietary changes, and stress management—the commonsense stuff we never learned in medical school.”

A Blueprint for Change

“Don’t Let Your Doctor Kill You” provides more than criticism—it offers a blueprint for navigating the system and advocating for yourself. Dr. Schwartz provides guidance on:

• How to prepare for doctor’s appointments to maximize your time and get your questions answered

• When to seek second (or third) opinions and how to evaluate conflicting advice

• Understanding the financial incentives that may be influencing your care

• Recognizing red flags that indicate your doctor isn’t listening or seeing you as a whole person

• Evaluating health information from both traditional and newer sources

• Finding physicians who practice patient-centered medicine

• Making lifestyle changes that can prevent or mitigate chronic disease

• When to trust your intuition over a doctor’s recommendation

The book concludes with Victoria Reggio sharing her transformation from passive patient to empowered self-advocate. After watching her sister Emily’s tragic journey through the medical system, Victoria made a conscious decision to take control of her health:

“I never wanted to be flat on my back again, helpless and wondering if I was going to live or die. I decided it was time to take control of my life. That meant taking control of my health.”

She reorganized her life around sleep, nutrition, exercise, and stress management. She learned to say “no” to demands that undermined her wellbeing. Most importantly, she stopped seeing herself as a helpless patient and became an active participant in her health.

Why This Book Matters Now

In a post-COVID world where trust in institutions has eroded and health information comes from increasingly diverse sources, “Don’t Let Your Doctor Kill You” provides a crucial framework for making informed decisions. The pandemic revealed just how fragile our healthcare system is and how quickly conventional wisdom can shift.

As artificial intelligence enters medicine and promises to revolutionize care, patients need guidance more than ever. Will AI enhance the doctor-patient relationship by handling routine tasks, or will it further dehumanize care by reducing humans to data points? Dr. Schwartz acknowledges AI’s potential while emphasizing that “what’s missing from AI is the humanity piece.”

Dr. Schwartz’s book serves as both warning and guide. It exposes a system designed to profit from illness rather than promote wellness, while empowering readers to navigate that system without becoming its victims.

In a healthcare landscape where both traditional authorities and new voices compete for your trust, “Don’t Let Your Doctor Kill You” reminds us of an essential truth: No

one will ever care more about your health than you do. By becoming an informed, assertive advocate for yourself, you can transform from a “perfect patient” into an empowered participant in your own wellbeing.

As Dr. Schwartz writes in her conclusion: “It’s your life. You must put yourself first and stop worrying about what the doctor thinks. By the time you finish reading this book, you will have the tools you need to change your role in your healthcare. You will go from being a passive observer in your own healthcare to actively being in charge of your life.”

Praise for Don’t Let Your Doctor Kill You

“Are you sick of being sick? Dr. Erika has once again proven that YOU are your best patient advocate. Put down your phone, turn off social media and pick up this book to guide you through the many medical minefields and put you on a proper path to health.”

-Kelly Ripa, TV host and patient

“Modern medicine is obsessed with managing disease, not restoring health. We’ve built an empire on fear and pharma — but healing doesn’t come from a prescription pad. It comes from understanding the body’s language, down to its smallest molecules. We’re not here to fight illness. We’re here to rebuild health, cell by cell. If you’ve ever felt betrayed by a system that should’ve protected you, this book will wake you up — and arm you with the truth. Dr. Erika Schwartz has done something few have the courage to do: speak out, stand up, and give power back to the people. Read every word.”

- Dayan Goodenowe, PhD, Neuroscientist, Top Researcher in Metabolomics, & BestSelling Author of Breaking Alzheimer’s

“In today’s complex medical landscape, understanding your own body is essential. This book serves as your interpreter, cutting through confusing medical terminology and empowering you to truly listen to your body’s signals. Learn to ask the right questions, avoid hasty conclusions, and take control of your health journey when consulting medical professionals. These are the tools you need to confidently navigate your wellbeing.”

- Trinny Woodall, Entreprenuer and Businesswoman

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Functional Health Panels

Booth #409

Access Medical Labs

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Central Drugs Compounding Pharmacy

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DOCTORSDATA.COM

Scan code to download Doctor's Data HuMapTM Clinical and Therapeutic Considerations Guide

HuMapTM Clinical & Therapeutic Considerations Guide

Booth #213

Doctor’s Data, Inc.

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Humann

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Booth #301

Olympia Pharmaceuticals

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Researched Nutritionals

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TA Sciences

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Vibrant Wellness

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Booth #319

University Compounding Pharmacy

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Lab Testing that Fuels Discovery

Genova o ers personalized solutions for understanding gut health, metabolic function, hormone balance, and more.

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MUSCLE OS-O1 (AMPK

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P3035: 2.4 grams per 1 tsp serving

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LuxMed Transition Strategies specializes in helping medical wellness, aesthetics, and integrative health clinics navigate practice transitions with confidence. Whether you are looking to sell, merge, expand, or bring in a strategic partner, we provide expert guidance to ensure you make the best decision for your practice’s future.

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Influencing Biological Age: Understanding Inflammaging and Metaflammation

By: Jim LaValle, RPh, CCN, MT Chief Science officer Life Time

Co-Chair American Academy of Anti-Aging Medicine, Chair International Peptide Society

Both health care professionals and consumers interest in the quest for lengthening healthspan and performance health is escalating, the race against the disease of aging and its effects on metabolic balance is a constant pursuit to create countermeasures to preserve vitality. With aging, we often focus on the visible signs: wrinkles, graying hair, body contours and changes in posture. However, a less noticeable but more insidious process occurs known as “inflammaging.” This is the chronic, low-grade inflammation process that contributes significantly to the aging process and the onset of age-related diseases.

Inflammaging is not merely a symptom, but a process characterized by the chronic upregulation of the immune response, leading to a steady state of inflammation signaling resulting in damage tissues, organs and eventually the mitochondrial level. This process is often silent until significant damage occurs, manifesting as various diseases such as arthritis, osteoporosis, diabetes, heart disease, and neurodegenerative diseases.

Inflammaging is driven by metaflammation (metabolic inflammation). Metaflammation is triggered by metabolic changes associated with a

Influencing Biological Age: Understanding Inflammaging and Metaflammation

multitude of factors such as skewed diets, genetics, nutrient status, insufficient physical or excessive activity, persistent stress or in many cases environmental burden or infection. As the damage accelerates from subsequent inflammatory cytokine, neurochemical and hormone dysregulation, the evolution of dyslipidemia, muscle loss due to reduced IGF-1 production, alterations in iron and ferritin regulation, insulin resistance, bone loss, decrease in neurogenesis and the most critical damage occurs as mitochondrial renewal and mitochondrial energy production is compromised due to alterations in NAD/NADH ratios.

The Roots of Inflammaging and Metaflammation

The source metaflammation and inflammaging have multiple root causes most of the time. With some causality having greater urgency. It involves the innate immune system becoming increasingly dysregulated as we age or because hormonal disruption, lifestyle choices, environmental intoxication, and other factors accelerate the process. You can trigger this cascade prematurely and accelerate your biological age. Factors such as cellular debris, accumulation of senescent cells, and the production of reactive oxygen species contribute to this chronic inflammatory state. The immune system, designed to eliminate pathogens and resolve inflammation, begins to falter and, paradoxically, promotes inflammation resulting in damage to cells, organs and tissue.

Detecting and Measuring Inflammation

Understanding whether you are on the path to inflammaging or metaflammation involves recognizing their markers. Chronic inflammation can often be detected through biomarkers in the blood, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Elevated levels of these markers can indicate ongoing inflammation and suggest an increased risk of agerelated conditions. Other metabolic markers such as mean platelet volume, glucose, insulin, galectin 3, adiponectin advanced lipid tests including Lpa, LP-PLAII2, oxLDL, ApoB and urine pH can paint a more complete picture of all the metabolic processes that may need to be addressed in order to return the body to homeostasis. One of the most important things to understand that it is not how

many therapies to apply, it is understanding the sequence of when to apply advanced protocols, whether it is peptides, senescent therapies, detoxification or mitochondrial targets. Continually pushing biochemical pathways through stimulation or inhibition can lead to negative feedback loops that could result in more cellular damage.

Strategies to Combat Inflammaging and Metaflammation

1. Dietary Adjustments: Adopting a diet rich in antiinflammatory foods is crucial. Testing for food allergies and sensitivities can be helpful and in some cases essential. Focus on a Mediterraneanstyle diet that includes plenty vegetables, modest fruit, nuts, whole grains as tolerated or needed based on activity level, and lean grass fed or wild caught protein sources. The core foundation to longevity is maintaining gut integrity. A dysregulated gut microbiome can lead to increased production of lipopolysaccharides (LPS). When the microbiome becomes stressed and have enhanced die off, LPS levels can increase. Combined with increased intestinal permeability (often referred to as “leaky gut”), more LPS enters the bloodstream attaching to tissues and crosses the blood brain barrier activating microglial cells resulting in neuroinflammation.

2. Regular Physical Activity: Exercise not only helps in managing weight but also in reducing metaflammation. Moderate, regular physical activity can lower the levels of pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines. In addition, exercise stimulates the glymphatic system to help clear by-products of brain metabolism. The harder you train the more you need to focus on recovery. Over training can be just as damaging as not exercising.

3. Adequate Sleep and Stress Management: sleep disturbances and high stress are significant contributors to inflammation. Insomnia is considered a disorder of hyperarousal, the brain takes on too much sympathetic stress and cannot shift to deep wave sleep preventing circadian regulation of the suprachiasmatic nucleus, release of growth hormone and disrupts insulin response. Ensuring sufficient sleep and managing

stress through techniques such as meditation, yoga, or even 4 minutes of box breathing 2-3 times a day helps to reset the vagus nerve and restore parasympathetic tone. Supporting nutrients such as glycine, inositol, magnesium, theanine, relora and melatonin can have a signficnat impact on sleep hygiene

4. Supplements: There are so many supplements, peptides and bioregulators that can help correct metaflammation and inflammaging. The key to the success of these nutrients is learning what to take and how to know it is working. Synapsin for cognition, BPC 157, KPV and curcumin for supporting inflammation or the repair of tissues, adaptogens, aged garlic extract, S-acetyl glutathione, the list goes on and on. One of the biggest mistakes I have seen in my 40 years of precision health and biohacking is that people will take too many compounds without a specific goal or a desired result.

5. Pharmacological Interventions: Pharmacological treatments may be necessary to manage chronic inflammation and they do play a role in longevity health. This is where compounding pharmacy and other services shine. Whether it is for peptides, methylene blue, bio-identical hormones or rapamycin, at times these interventions can accelerate results and reverse meta inflammatory processes.

Conclusion

Inflammaging and metaflammation are not just buzzwords but real phenomena that affect health resilency, healthspan and longevity. By understanding these processes and integrating practices into daily life, the march toward the disease of aging can be minimized. As I often say, managing inflammation is not just about extending life— it’s about enhancing the quality of every year we gain.

EXHIBITOR INDEX

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EXHIBIT HALL A & B

EXHIBITOR LISTINGS

Booth #807

3120 139th Avenue Ste 500 Bellevue, WA 98005

USA

Ph: (425) 818-5333

Email: info@3x4genetics.com www.3x4genetics.com

Through just a single test, the 3X4 Genetic Blueprint gives you access to a paradigmshifting health and wellness tool that will equip you with everything you need to make empowered decisions about your own health.

Medical Labs

USA

Ph: (866) 720-8386

Email: info@accessmedlab.com www.accessmedlab.com

Access is the nation’s premier specialty diagnostic lab. We offer a broad menu of testing from blood, saliva, urine & swab samples. We perform all of your tests in our 25,000 sq. ft. ultra-automated facility in Jupiter, Florida & provide results within 24hrs. Since 2003, we continuously strive to innovate, inspire and improve solutions for physicians by providing an exceptional personalized experience with the most accurate testing.

Booth #90

1801 N Military Trail Ste 110 Boca Raton, FL 33431 USA

Ph: (561) 997-0112

Email: info@a4m.com

www.a4m.com

Driven by a visionary mission to revolutionize healthcare, The American Academy of Anti-Aging Medicine (A4M) is the world’s leading provider of advanced medical education in functional, preventive, and longevity medicine. Through its diverse array of innovative learning opportunities, A4M equips forwardthinking practitioners with the expertise and tools to deliver personalized, whole-person care that optimizes health, vitality, and resilience at every stage of life.

ACCESS CARE PHARMACY

Booth

#947

2601 S Military Trail Ste 25 Palm Beach, FL 33415 USA

Ph: (561) 660-7869

Email: INFO@ACPHARMACYFL.COM acpharmacyfl.com

ACCESS CARE PHARMACY IS A SPECIALIZED COMPOUNDING PHARMACY DEDICATED TO PERSONALIZED PATIENT CARE . WE COMPOUND FORMULATIONS FOR HORMONE THERAPY , ANTI-AGING , SKIN CONDITIONS , MELASMA ,PSORIASIS ,ARTHRITIS, AUTISM , VAGINAL DRYNESS ,MENOPAUSE WITH EXCELLENT QUALITY AND INNOVATION, WE HELP PATIENTS TO ACHIEVE BETTER HEALTH AND WELLBEING THROUGH PRECISION COMPOUNDING AND EXCEPTIONAL CUSTOMER SERVICE .

Health

N Lincoln Avenue

IL 60625

Ph: (773) 598-4387

Email: info@alignedmodernhealth.com alignedmodernhealth.com

Aligned Modern Health is a leading lifestyle medicine brand with 18 clinics across Chicagoland. Our inclinic and virtual Lifestyle Medicine Doctors provide outstanding clinical outcomes and patient experiences using modern diagnostic testing and nutritional science to correct imbalances and treat chronic disease. They work closely with Chiropractic Physicians, Massage Therapists, and Acupuncturists in a multidisciplinary, evidence-based model that offers solutions to hormone issues, stress/anxiety, autoimmunity, GI distress, infertility, musculoskeletal pain, and more.

AllCore360

6039 Rock School Road

Harpersville, AL 35078

USA

Ph: (833) 228-9922

Email: sales@allcore360.com

www.allcore360.com

Experts know core stability is at the heart of overall balance and strength. With the AllCore360º training program, you can offer your clients a turnkey solution that positions your business as a leader in core therapy and performance, and improves mind, body, and spirit. Regardless of mobility, AllCore360 training helps patients recover faster and improve total physical performance.

Alletess Medical Laboratory

Booth #927

14 Howard Street

Rockland, MA 02370

USA

Ph: (800) 225-5404

Email: alletess@foodallergy.com foodallergy.com

Founded in 1980, Alletess Medical Laboratory has been providing allergy and immunology testing services to clinicians worldwide. Our highly knowledgeable staff, cutting-edge medical technology, and customized wellness programs allow us to provide high-quality laboratory testing and services to our clients. We understand that test results impact patient lives, every day we strive to provide test results with actionable information to clinicians to improve patient’s health and quality of life. The test result is the beginning of the journey.

AnazaoHealth

Booth #128

5710 Hoover Blvd Tampa, FL 33634

USA

Ph: (800) 995-4363

Email: jvillalona@anazaohealth.com anazaohealth.com

AnazaoHealth is a specialty compounding pharmacy focusing on Wellness, Pain Management and Nuclear Medicine. We have a 30,000-square-foot 503B FDA-Registered Outsourcing Facility in Las Vegas and a 46,000-square-foot traditional 503A compounding pharmacy in Tampa. Both facilities have the appropriate licensure to conduct business in most states, the District of Columbia, and selected U.S. territories. Leading the future of compounding AnazaoHealth compounds preparations for Age Management, Weight Management, IV Therapy, Sexual Health, Vitamin Injections, Hormone Replacement, Hair Care Solutions & Aesthetics.

Pennsylvania Avenue Sarasota, FL 34243

USA

Ph: (941) 702-6100

Email: sales@n-icorp.com

www.Argentyn23.com

We have been the #1 leader in Bio - Active Silver and Copper Hydrosol for 25 years! Only using 99.9999% pharmaceutical grade water and silver. Making our product the most pure and effective supplement for our immune system and overall health.

ASEA

1488 W. Pleasant View Drive Pleasant Grove, UT 84062

USA

Ph: (801) 973-7499

Email: support@aseaglobal.org www.aseaglobal.com

ASEA is a wellness company founded on—and fueled by—human potential. Based in Utah and spanning worldwide, ASEA is a pioneering leader in cellular health. ASEA is the first to bring to market revolutionary redox signaling molecules, helping your cells work together as they’re meant to do. These lifesustaining cellular messengers can protect, rejuvenate, and optimize cellular health. Today, we operate in 34 markets where we have impacted hundreds of thousands of lives. ASEA ~ We power potential®

APEX Biologix

Booth #244

19321 US Hwy. 19 N Bldg.A

Clearwater, FL 33764

USA

Ph: (844) 897-4910

Email: info@apexbiologix.com apexbiologix.com

We strive to provide our customers with the latest regenerative medicine equipment and supplies, including PRP, BMC, MFAT, and Protein Concentrate, to keep them at the cutting edge of one of the most exciting and promising areas of modern medicine.

Co.

762650 Fred Waring Drive Ste 206 Palm Desert, CA 92260

USA

Ph: (818) 822-9726

Email: m.williams@bellavitaclinics.com bellavitaclinics.com

BellaVita Trading Co™: Advancing hormone optimization with expert care & support.

BHI Therapeutic Sciences

Booth

#246

214 State Street Ste 101

Hackensack, NJ 07601

USA

Ph: (212) 206-7073

Email: info@bluehorizoninternational.com www.bluehorizoninternational.com

At BHI Therapeutic Sciences, we harness the power of regenerative medicine to help patients reach their optimal health, which can alleviate pain and promote injury repair and disease management. Stem cell therapies continue to enhance the field of regenerative medicine and what it offers patients and scientists. Led by Brian Mehling, MD, board certified in orthopedic surgery and anti-aging and regenerative medicine, BHITS possesses a rich research background, with numerous publications in peer reviewed USA and international journals.

BodyHealth

745 Main Street Dunedin, FL 34698

USA

Ph: (877) 804-3258

Email: wholesale@bodyhealth.com www.bodyhealth.com

About BodyHealth BodyHealth is a trusted leader in premium nutritional supplements, dedicated to supporting optimal health, peak performance, and total body wellness. Founded with a commitment to scientific integrity and clean, high-quality ingredients, BodyHealth formulates products that enhance energy, muscle recovery, gut health, and overall vitality. The company’s mission is to empower individuals—whether athletes, health-conscious consumers, or healthcare practitioners—with cutting-edge supplements designed to fuel the body and optimize well-being.

Big Bold Health

Booth

#247

115 Hall Brothers Loop

Bainbridge Island, WA 98110 USA

Ph: (253) 208-4339

Email: kellybland@bigboldhealth.com pro.bigboldhealth.com

We are a team of doctors, researchers, nutritionists, and natural products experts committed to restoring human health through the boundless power of nature. In the soil and sea lie elements with astonishing properties. The power to restore. To rejuvenate. To rebuild, cell by cell. That’s why we cultivate nature’s purest elements at their height of potency. Sourced with extraordinary care to regenerate the whole.

Biotics Research

Booth #813

5245 Business Park Drive

Rosenberg, TX 77469

USA

Ph: (800) 231-5777

Email: communications@bioticsresearch.com www.bioticsresearch.com

Biotics Research Corporation was formed in 1975 and from day one the foundation has been “Innovation and Quality.” Our goals remain unchanged - innovative ideas, carefully researched concepts, and product development with advanced analytical and manufacturing techniques to develop and produce nutritional products of superior quality and effectiveness available exclusively to healthcare professionals. 1-800-231-5777 www.bioticsresearch.com

BOIRON

#1019

4 Campus Boulevard

Newtown Square, PA 19073

USA

Ph: (610) 325-8358

Email: carol.angelo@boiron.com www.boironusa.com

Boiron, world leader in homeopathic medicines, is best known for its pharmaceutical grade-quality drugs such as its Arnicare® line of pain relievers and Oscillococcinum® flu reliever. Founded in 1932, Boiron is the largest pharmaceutical company in its home country of France. With subsidiaries in 19 countries, Boiron distributes products in more than 50 countries in categories such as analgesics, cough, cold, flu, first aid, baby and children’s, oral and eye care, indigestion, and women’s health.

Boston Heart Diagnostics

Booth #1008

200 Crossing Blvd

Framingham, MA 01702

USA

Ph: (877) 425-1252

Email: customercare@bostonheart.eurofinsus. com

bostonheartdiagnostics.com

Boston Heart Diagnostics is transforming the treatment of cardiovascular and related diseases through novel clinical diagnostics, therapeutically focused reports, and personalized, scientifically designed nutrition and lifestyle programs that have the power to change the way healthcare providers and patients communicate about heart health.

BrainMaster Technologies Inc.

Booth

#902

195 Willis Street Bedford, OH 44146

USA

Ph: (440) 232-6000

Email: sales@brainmaster.com brainmaster.com

BrainMaster offers the most cutting edge and comprehensive variety of Clinical EEG, 3D Brain Imaging, QEEG and Neurofeedback on the market. Application areas include real-time imaging utilizing sLORETA, normative databases and pre/post therapeutic comparison. Clinical and personal database driven Neurofeedback, biofeedback, peak-performance, research, VR and brain-controlled systems. Partner with us, and help us change lives, one brain at a time!

BTL

Booth #838

362 Elm Street Marlboro, MA 01752

USA

Ph: (866) 285-1656

Email: info@btlnet.com bodybybtl.com

Founded in 1993, BTL has grown to become one of the world’s major medical and aesthetic equipment manufacturers. With 2,800 employees located in more than 71 countries, BTL has revolutionized the way to offer the most advanced non-invasive solutions for body shaping, skin tightening & other medical aesthetic treatments, including women’s intimate health and wellness. BTL’s brands include EMFACE, EMSCULPT NEO, EMSCULPT, EMSELLA, EMTONE, EMFEMME, and BTL Exilis ULTRA. Additional information can be found at www.bodybybtl.com.

Calmoseptine, Inc.

Booth #347

16602 Burke Lane

Huntington Beach, CA 92647

USA

Ph: (714) 840-3405

Email: Info@calmoseptine.com

calmoseptineointment.com

Calmoseptine Inc. markets Calmoseptine Ointment in all 50 states, Canada, United Arab Emirates, Jordan, Cuba, Peru, and Chili. Calmoseptine Ointment is an effective, multi-purpose moisture barrier that protects and helps heal skin irritations. Calmoseptine Ointment is available in 2.5-oz jars or tubes, 4-oz tubes, 1/8-oz packets, and 20g tubes through most wholesalers, distributors and pharmacies. For more information, please call us at 800-800-3405, e-mail us at info@ calmoseptine.com, or visit www.calmoseptine.com.

Calocurb Limited

Booth #1012

17B Farnham Street Ste 13517

Auckland, Auckland 01010

New Zealand

Ph: (642) 196-5440

Email: clinic@calocurb.com wholesale@calocurb.com

Calocurb is a clinically proven, natural GLP-1 activator. With 14 years and $20m invested in research, 3 human trials have shown that this supplement can stimulate GLP-1 to 600% above base level (+400% is required for gut-brain connection), reducing cravings by 40%, hunger by 30% and average calorie intake by 18%. Practitioners use Calocurb as a weight health support tool, or to compliment GLP-1 injectable ‘off ramping’, stimulating natural GLP-1 production and helping maintain weight loss.

BWH Labs

Booth #1130

1000 Cobb Pl. Blvd NW Ste. 407 Kennesaw, GA 30144

USA

Ph: (855) 504-5005

Email: support@bwhlabs.com bwhlabs.com

BWH Labs is dedicated to providing the purest and most biologically active Beta Glucan on the market.

Calroy Health Sciences

Booth #201

14362 N Frank Lloyd Wright Ste 1000 Scottsdale, AZ 85260 USA

Ph: (800) 609-6409

Email: support@calroy.com www.calroy.com

Advancing Science. Enhancing Health. At Calroy, we translate breakthrough science into unparalleled products. Through rigorous research and formulation, we develop transformative solutions for foundational health. Our team pioneers emerging scientific research and leverages expertise in world-class natural ingredients to craft our formulas. For premier vascular support, look to Calroy products - they work synergistically and standalone. We also regularly host educational series with vascular care experts and would love to see you there. Sign up for updates at calroy.com

Castle Connolly Private Health Partners, LLC

Booth #1146

530 7th Avenue Ste 2401

New York, NY 10018

USA

Ph: (212) 367-1950

Email: info@ccphp.net ccphp.net

Castle Connolly Private Health Partners works to empower and protect the physician-patient relationship through a concierge medicine model, helping physicians practice the way they intended, and patients to receive the care they deserve.

CellCore Biosciences

Booth #919

3399 PGA Boulevard Ste 300 Palm Beach Gardens, FL 33410

USA

Ph: (866) 902-1525

Email: support@cellcore.com cellcore.com

CellCore Biosciences provides supplements that address the underlying issues that may be impacting your patient’s health, such as toxins, pathogens, or infections. By supporting mitochondrial energy, proper drainage and detoxification processes, we achieve optimal organ function. As a result, the patient’s body is better prepared for further treatment if necessary. With BioActive Carbon, a proprietary blend of fulvic acids, CellCore products help bind, protect, and deliver essential nutrients to the body for maximum benefit.

Cell Science Systems

Booth #1118

852 S. Military Trail Deerfield Beach, FL 33442

USA

Ph: (800) 872-5228

Email: info@cellsciencesystems.com www.cellsciencesystems.com

Cell Science Systems is the developer and provider of the ALCAT Test®, the only validated blood test for food and chemical sensitivities. The ALCAT Test® is also useful for testing adverse reactions to medicinal herbs and functional foods that are often used in anti-aging protocols. Cell Science Systems also provides tests for nutritional assessment, antioxidant status, gut health, telomere length and others.

Cellcolabs

Booth #437

Scheeles vag 5, 171 65 Solna, Stockholms Lan 17165

Ph: 44 7717 311307

Email: nina.leibenfrost@cellcolabs.com cellcolabs.com

Cellcolabs is a Swedish biotech company specializing in large-scale mesenchymal stem cell (MSC) production. Its mission is to prevent and cure diseases by making high-quality stem cells accessible and affordable through industrial-scale production and partnerships. Following protocols developed by Professor Katarina Le Blanc at Karolinska Institutet for 20+ years, Cellcolabs was founded in 2021 and led by CEO Mattias Bernow. Its subsidiary, Cellcolabs Clinical, conducts patient funded clinical trials in the Bahamas on musculoskeletal injuries and cardiovascular disease prevention.

Central Drugs Compounding Pharmacy

Booth #311

520 W. La Habra Blvd La Habra, CA 90631

USA

Ph: (562) 691-6754

Email: clinicalrph@centraldrugsrx.com centraldrugsrx.com

Central Drugs is an industry leader in the art and science of custom compounding and individualized health-care solutions with a team of expert pharmacists at our state-of-the-art 503A compounding pharmacy. Central Drugs is your pharmacy partner, working with clinics to provide resources, education, and services to improve the overall health of your patients. Central Drugs specializes in compounding, seeking the most innovative, effective and trending formulations to meet the needs of clinics across 30 states.

Cerbo EHR

Booth #1134

350 SE Mill Street Ste 11 Portland, OR 97214

USA

Ph: (541) 391-4600

Email: sales@cer.bo Cer.bo

Cerbo is a powerful and user-friendly electronic health record (EHR) platform designed to help healthcare providers streamline patient management and elevate care. Built for cash-based, direct primary care (DPC) and functional medicine practices, Cerbo has the tools and flexibility you need to work more efficiently while enhancing the patient experience. It’s the all-in-one solution for modern healthcare.

Chromadex

Booth #942

1735 Flight Way Ste 200 Tustin, CA 92782

USA

Ph: (949) 410-3984

Email: practitioner@truniagen.com Pro.truniagen.com

Your NAD+ supply declines with age as well as in response to stressors on your body including alcohol consumption, intense exercise, and lack of sleep. While nicotinamide riboside can be found naturally in certain foods, you cannot get anywhere near the amount you need through a normal diet to effectively increase NAD+. That is why we created Tru Niagen®, the only patented, broadly studied, and safety-reviewed nicotinamide riboside in the world.

College Pharmacy

Booth #839

3505 Austin Bluffs Pkwy Ste.101 Colorado Springs, CO 80918

USA

Ph: (800) 888-9358 x137

Email: sky@collegepharmacy.com www.collegepharmacy.com

THE COLLEGE PHARMACY DIFFERENCE: QUALITY. INNOVATION. EXPERIENCE. SINCE 1974. For over 50 years, College Pharmacy has provided healthcare practitioners and patients with high-quality compounded preparations and outstanding customer service. Our experienced pharmacists collaborate with patients and healthcare practitioners to provide innovative solutions for health and wellness success. It is our compounding process, attention to detail, and quality of the compounding components that continues to make our formulations exceptional.

Circulate Health Booth #1137

1424 11th Avenue Ste 400 Seattle, WA 98122

USA

Ph: (360) 362-6196

Email: sara@circulate.health www.circulate.health

We are pioneering technologies and treatments to reverse aging and improve health outcomes. We are committed to innovating how people live healthier and longer lives by centering our approach on extensive research and clinical trials. Therapeutic Plasma Exchange (TPE) by Circulate is an evidence-based treatment that removes toxic, inflammatory, disease-causing and ageaccelerating substances from the bloodstream. Find out how you can offer TPE to your patients for zero upfront costs and zero operational burden.

Clinicians Supplement Consultants

Booth #1035

180 Froehlich Farm Blvd Woodbury, NY 11797

USA

Ph: (516) 222-2288

Email: dlc@cscprivatelabel.com www.cscprivatelabel.com

Clinicians Supplement Consultants allows practitioners to provide concierge service and sales of professional supplement brands and practitioners own private label supplements to their patients. CSC has an exclusive professional only brand, a concierge supplement fulfillment service, a private label development and management program. CSC allows practitioners focus on the patient while CSC handles all aspects of inventory, dispensing, fulfillment, and patient compliance . CSC handles the supplement business allowing practitioners to focus on their patients.

COSMED USA

Booth #642

1850 Bates Avenue Concord, CA 94520 USA

Ph: (925) 676-6002

Email: USA@cosmed.com www.cosmed.com

COSMED provides a complete portfolio of gold standard solutions for performance testing, including exercise testing, metabolic assessment and body composition analysis. Key products include the K5 Wearable Metabolic System, the Q-NRG Metabolic Monitor and the BOD POD GS-X Body Composition System. We also provide a comprehensive software solution called OMNIA that seamlessly integrates all products & data together to allow for analysis and trending.

CRE8 Pharmacy

Booth

#719

3700 NW 126th Avenue Coral Springs, FL 33065 USA

Ph: (888) 224-5181

Email: david@cre8rx.com www.cre8pharmacy.com

CRE8 Pharmacy offers compounding services for personalized medicine and patient-specific prescriptions. We are a team, working at creating perfect formulations, dispensing orders reliably and resolving any issues promptly. Licensed in 43 States CRE8 Pharmacy specializing in Peptides, Hormone Replacement Therapy, Sexual Wellness, Weight Loss & Energy, Cognitive & Mental Health formulas. Sterile & Non-Sterile compounds, Generic & Brand medications. Welcome to the future of compounding pharmacy.

Cyrex Laboratories

Booth

#235

2602 S. 24th Street

Phoenix, AZ 85034

USA

Ph: (657) 210-8029

Email: kara.b@cyrexlabs.com

www.JoinCyrex.com

Cyrex™ is a Clinical Immunology Laboratory Specializing in Functional Immunology and Autoimmunity. Cyrex™ offers multi-tissue antibody testing for the early detection and monitoring of today’s complex autoimmune conditions. Cyrex™ develops innovative arrays through continuous collaboration with leading experts in medical research and clinical practice.

Designs for Health

14 Commerce Blvd Palm Coast, FL 32164

USA

Ph: (860) 623-6314

Email: orders@designsforhealth.com www.designsforhealth.com

Our Mission: Designing a Well World We are driven by a higher purpose. We are activists for health - rooted in and united by science. Transforming boundaries, breaking barriers, setting new standards, disrupting the status quo. We believe in sciencebased nutrition and natural medicine, developing health products without compromise, and advancing the way education and technology support wellness for all. We design a new paradigm. We design a well world. We are Designs for Health.

Delavie Sciences

Booth #446

365 Plantation Street Ste 175

Worcester, MA 01605 USA

Ph: (508) 459-8803

Email: info@delaviesciences.com

www.delaviesciences.com

From the outer reaches of space to 5000 feet below the earth, our discovery scientists go to the extremes to discover entirely new ingredients that survive and thrive under the most intense conditions imaginable. We use these patented and proprietary discoveries to formulate bio-optimized skincare that embraces and empowers you on a cellular level—encouraging highest function, extended health, and ultimate longevity.

Designer Drugs Pharmacy

Booth

#635

7304 Jarnigan Road

Chattanooga, TN 37421

USA

Ph: (423) 954-2585

Email: form-submission@squarespace.info www.designerdrugs.us/

For more than 20 years, Designer Drugs has been working with patients and physicians to provide custom solutions for their pharmaceutical and clinical needs. Our technicians are certified to compound sterile and non-sterile medications. Our pharmacy proudly compounds ophthalmics, injections, dermatologics, HRT, and many more antiaging products. These preparations are designed to meet individual needs with the highest level of safety and accuracy. Designer Drugs is licensed to dispense and ship prescriptions to all fifty states.

Detox Pure Elements,

Dinhurts Ct Lutz, FL 34639 USA

Ph: (813) 438-7040

Email: customerservice@detoxpure.com

DetoxPure.com

DetoxPure Elements is a cutting-edge supplement brand designed to help your body detoxify from harmful toxic molds and other environmental toxins. Mycotoxins, which are toxic compounds produced by mold and fungi, can accumulate in your body and impact your health in various ways—causing fatigue, brain fog, digestive issues, and more. DetoxPure Elements was developed to combat these hidden dangers and assist your body in cleansing itself naturally and effectively.

Diagnoptics Technologies b.v

Aarhusweg 4-9 Groningen, Groningen 9723JJ

Ph: 31 50 589 0612

Email: sales@diagnoptics.com

www.age-scanner.com

Diagnoptics develops and markets a non-invasive diagnostic technology, which can assess the tissue accumulation of AGEs. The AGE Scanner is a cuttingedge, non-invasive device that instantly measures Advanced Glycation End-products (AGEs), a key biomarker of premature aging and metabolic health. Backed by 20 years of scientific research, it empowers CAM professionals with personalized insights to optimize patient wellness and longevity. Used worldwide, the AGE Scanner enhances preventive care strategies with quick, reliable assessments.

Diagnostic Solutions Laboratory

Booth #243

31 Lupi Court Ste 250 Palm Coast, FL 32137

USA

Ph: (877) 485-5336

Email: cs@diagnosticsolutionslab.com www.diagnosticsolutionslab.com

Diagnostic Solutions Laboratory is a functional medicine laboratory that offers cutting-edge laboratory tests including the GI-MAP stool test, OAp Organic Acids Profile, OMX (Organic Metabolomics) and more! Our test offerings help reveal the underlying root causes of symptoms and disease, providing practitioners with essential tools to develop tailored treatment plans that maximize patient health outcomes. Take the first step towards revolutionary healthcare solutions. Contact Diagnostic Solutions Laboratory today to explore advanced testing options designed to elevate your diagnostic capabilities.

2601 S. Bayshore Drive 18th Floor Coconut Grove, FL 33133

USA

Ph: (305) 398-7757

Email: drivanassist@lfstm.com www.lfstm.com

Dr. Ivan Rusilko Lifestyle Medicine is at the forefront of revolutionizing healthcare delivery by bridging the gap between traditional medicine and wellnessbased practices. Our mission is to empower a diverse network of healthcare providers to establish efficient, technology-driven online clinics—what we term as a “business in a box.” Whether you are a conventional medical doctor or a physician with alternative qualifications, Dr. Lifestyle Medicine equips you to elevate your practice and meet the needs of your patients effectively.

#1100

7135 E. Camelback Road Ste 230 Scottsdale, AZ 85251

USA

Ph: (725) 222-5468

Email: info@docovia.com

www.docovia.com

Docovia is a software platform which helps businesses streamline and simplify their new patient acquisition. Docovia can capture leads from your website or social channels as well as offer ondemand virtual telehealth services with our team of Nurse Practitioners who are available 7 days a week to meet virtually with your patients to assess the patient’s medical history and/or complete a Good Faith Exam (GFE) in roughly 5-7 minutes. Reach out today for your first 10 exams at no cost!

Doctor’s Data, Inc.

Booth

#213

3755 Illinois Avenue

St. Charles, IL 60174

USA

Ph: (630) 377-8139

Email: info@DoctorsData.com www.doctorsdata.com

Doctor’s Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced, CLIA-licensed clinical laboratory since 1972. A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, hormone status, cardiovascular risk, liver and metabolic abnormalities, and more.

Dr. Fuji / ACIGI

4399 Ingot Street Fremont, CA 94538

USA

Ph: (510) 651-9088

Email: marketing@drfuji.com www.drfuji.com

DRFUJI/ACIGI CO. has been in the health and wellness business for 30 years. With a background in eastern medicine and experience as a former orthopedic surgeon in Asia, he specializes in using acupuncture to alleviate chronic pain. In addition to providing acupuncture treatments, he has been designing and developing innovative fitness, health, wellness, and beauty products to help people achieve a higher quality of life since 1992.

DrTalks

7040 Avenida Encinas Ste 104-284 Carlsbad, CA 92011 USA

Ph: (619) 436-7750

Email:

DrTalks was established to provide real people with access to leading experts in health, wellness, and medical fields. Through our exclusive partnership, we offer ongoing, curated content tailored to your interests. Whether you’re looking to unlock the secrets of genetics, enhance your health through nutrition and exercise, learn about the latest cancer breakthroughs, or manage chronic conditions and pain, we bring you the latest insights directly from the doctors themselves.

Docovia

Booth

Dr Ivan Rusilko Lifestyle Medicine

Booth #331

Booth #1147

Booth #139

DrWell by BuildMyHealth

Booth

#535

2100 Webster Street Ste 429 San Fransico, CA 92114

USA

Ph: (401) 649-0086

Email: chad@drwell.com www,drwell.com

DrWell is a provider-to-consumer platform designed to help patients connect with trusted medical providers to kickstart their weight and wellness journeys. Unlike traditional direct-to-consumer platforms, we empower healthcare providers to offer the same high-quality, technology-driven experience with a more personalized and patient-centered approach.

DUTCH Test

Booth #601

3138 NE Rivergate Street McMinnville, OR 97128

USA

Ph: (503) 687-2050

Email: sales@dutchtest.com www.dutchtest.com

Precision Analytical created the DUTCH Test (dried urine test for comprehensive hormones) to help providers solve complex patient cases and profoundly change lives. DUTCH is a group of accurate and research-validated tests that provide a complete evaluation of a patient’s sex and adrenal hormones, including metabolites. The DUTCH Test uses convenient at-home collection with unparalleled clinical support and education, to give providers the tools they need to solve their patients’ most complex hormone-related issues.

3500 South DuPont Hwy Dover, DE 19901

USA

Ph: (628) 212-0588

Email: jose.flores@entity-health.com entity-health.com

At Entity, we go beyond basic nutrition to bring you effective products that are clinically proven to support longevity and healthspan. Our team of scientists, medical doctors, and pharmacists leverage the latest research to develop targeted, innovative supplements that address key areas of aging, such as energy & vitality, skin health, and sleep. Our products are designed not only to maintain your health but to enhance your quality of life at any age. We believe in visible, perceptible results!

Ergo-Flex Technologies

13622 Poplar Circle Ste 403 Conroe, TX 77304 USA

Ph: (936) 588-5510

Email: sales@ergoflextechnologies.com www.ergoflextechnologies.com

ERGO-FLEX Technologies, LLC is the developer, manufacturer, and distributor of innovative equipment for chiropractic and therapeutic healthcare professionals that provide extraordinary results for patients experiencing chronic pain. Our flagship products include Back on Trac and Knee on Trac. Ask us about our newest product introducing “Responsive Oxygen Therapy”.

Enlyte

Booth #543

PO Box 510 susnet, LA 70584 USA

Ph: (985) 290-1893

Email: customercare@enlyterx.com www.enlyterx.com

EnLyte Gel Cap contains all the methylation vitamin coenzymes, mineral cofactors, and phospholipids needed to normalize and balance neuronal biochemical endpoints correlating to Major Depressive Disorder remission in well-controlled clinical trials; thus, addressing root cause treatment principles.

Evexia Diagnostics

Booth #534 PO Box 1272 Washington, CT 06793 USA

Ph: (888) 852-2723

Email: sales@evexiadiagnostics.com www.evexiadiagnostics.com

A complete suite of diagnostic and laboratory solutions for health professionals Evexia Diagnostics provides comprehensive, cuttingedge, clinical laboratory services at unbeatable prices, focusing on Functional Medicine and Integrative Medicine, cash-based practice. We have spent more than a decade developing our state-of-the-art, proprietary infrastructure to better facilitate the needs of our clients, including both licensed and non-licensed clinicians. Our number one priority is to deliver fast, affordable, and reliable solutions to maximize your efficiency and profitability while delivering best-in-class service.

Booth #1045

EVEXIAS Health Solutions

Booth #607

920 S. Kimball Avenue STE 100 Southlake, TX 76092

USA

Ph: (888) 299-7544

Email: marketing@evexias.com

EVEXIAS.COM

EVEXIAS Health Solutions is the leading provider of integrated wellness solutions for men and women seeking relief from symptoms of hormone imbalance, including hot flashes, anxiety, weight gain, muscle loss, and sexual dysfunction. Our providers are experts at helping patients discover total wellness through integrative medical therapies, including hormone pellet therapy, nutraceuticals, and health lifestyle changes.

Formula30A

1992 Lewis Turner Blvd Fort Walton Beach, FL 32547

USA

Ph: (888) 366-7070

Email: info@formula30a.com www.formula30a.com

Formula30A collaborates exclusively with healthcare providers to offer premium, all-natural cannabinoids, including cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidiol (CBD), and cannabidiolic acid (CBDA). Utilizing a patented, solvent-free extraction process, our full-spectrum products are triple third-party tested to ensure purity and potency. Committed to advancing cannabinoid education and research, and the first company to perform an IRB-approved study on CBG in healthy adults, Formula30A empowers healthcare professionals to enhance patient wellness through safe, effective, and consistent cannabinoid therapies. Pure. Clean. Simple.

Evitalin

Booth #1144

14440 Myerlake Circle Clearwater, FL 33760

USA

Ph: (857) 233-5837

Email: certel@menmd.com

www.evitalin.com

Connecting you to more than medicine. From premium medications to direct pharmacy expertise, we provide a wide range of quality solutions your practice needs to succeed and grow.

Evolt

Booth #729

2457 Aviation Avenue Ste102 North Charleston, SC 29406

USA

Ph: (888) 983-8658

Email: info@evolt360.com wwww.evolt360.com

Evolt is a pioneering company specializing in advanced body composition analysis solutions, catering not only to individuals but also offering extensive benefits to businesses. Our state-of-the-art technology empowers fitness centers, wellness facilities, and healthcare providers to deliver personalized services, enhance client engagement, and drive business growth. Visit EVOLT360.COM for more information.

Forum Health

601 S. Saginaw Street 5th floor Flint, MI 48502

USA

Ph: (331) 645-2310

Email: info@forumhealth.com www.forumhealth.com

Forum Health is a growing network of healthcare providers & practices who serve patients around the world. Our providers have decades of experience practicing functional and integrative medicinedrawn from areas in clinical nutrition, anti-aging, environmental science, chronic disease, lifestyle medicine and more. Through practice acquisition and employing talented healthcare providers, we connect the best like-minded practitioners with business experts and a network of collaborative peers. Become part of our network today!

Fotona, LLC

Booth #218

4343 W Royal Lane Ste 116 Irving, TX 75063

USA

Ph: (469) 203-7839

Email: info@fotona.org www.fotona.com

With over 60 years of laser expertise and industry leadership, Fotona has sold over 30,000 lasers worldwide with distribution in over 60 countries. Fotona produces award-winning lasers in dentistry, aesthetics, dermatology, gynecology, and surgery. Having a strong history of dedication to R&D, Fotona has a reputation for unparalleled quality, reliability, ease-of-use and durability.

Booth #1006

Booth #339

Fullscript and Rupa Health

Booth #513

1750 Elm Street #1200

Manchester, NH 03104

USA

Ph: (866) 807-3828

Email: support@fullscript.com

fullscript.com

Fullscript has acquired Rupa Health, an industry leader in simplifying lab management. Together, we’re building a singular platform to access healthcare’s best supplements, industry-leading labs and a full suite of clinical tools to fuel your care cycle. Easily streamline your practice to order tests from a vast catalog featuring 30+ lab companies and recommend products from 375+ trusted supplement brands. Sign-up for free to learn how each platform can work for your practice!

Generation Lab

Booth

#114

893A Folsom Street

San Francisco, CA 94107

USA

Ph: (415) 786-3451

Email: info@generationlab.com www.generationlab.com

Generation Lab, founded from the UC Berkeley Longevity Lab, is revolutionizing health diagnostics by offering the only test that measures aging at the organ level. Our cutting-edge technology assesses biological aging across 19 organs, providing unparalleled insight into personalized health and longevity. By analyzing organ-specific aging patterns, we empower individuals and healthcare providers with actionable data to optimize health, prevent disease, and extend vitality. Generation Lab is redefining the future of precision medicine and longevity science.

Global Life Rejuvenation

Booth #735

168 East Main Street

Denville, NJ 07834

USA

Ph: (973) 627-1750

Email: demetriaglaab@denvillemedical.com

globalliferejuvenation.com

Global Life Rejuvenation A Leader in Anti-Aging Medicine and Hormone Replacement Therapy for Men and Women. Global Life Rejuvenation has Network Providers nationwide. Global Life educates and connects patients with our highly trained network physicians specializing in Anti -Aging Medicine.

GlycanAge Ltd.

Booth #1136

3 Science Square

Tyne & Wear, England Newcastle UK

Ph: 44 7528 203659

Email: jonathan@glycanage.com glycanage.com

GlycanAge, built on 30+ years of research and $40M in funding, measures chronic inflammation to reveal true biological age. Trusted by leading longevity clinics, functional medicine practitioners, and health optimization experts worldwide, it tracks response to interventions like HRT, TRT, and weight management. Empower your clients with data-driven, personalized, preventative health strategies and measurable progress.

Genova Diagnostics

Booth #327

63 Zillicoa Street

Asheville, NC 28801 USA

Ph: (828) 210-7362

Email: info@gdx.net www.gdx.net/

Genova Diagnostic is a leading health and wellness laboratory dedicated to advancing personalized healthcare through innovative diagnostic testing. Our comprehensive assessments provide insights into gut health, nutrition, metabolic function, hormonal balance, and immunology, empowering healthcare practitioners to develop targeted treatment plans for optimal health outcomes. With a commitment to rigorous scientific research and clinical excellence, we offer cuttingedge testing designed to uncover the root causes of health issues and guide effective interventions. For more information, please visit gdx.net.

GutID

Booth #1047

400 Farmington Avenue

Farmington, CT 06032 USA

Ph: (906) 364-3012

Email: ask@gutid.com www.gutid.com

GutID is transforming gut health with the first truly accurate microbiome test, powered by Intus Biosciences’ proprietary Titan-1™ platform. Unlike traditional tests, GutID™ identifies all the bacteria in your gut—including rare and previously unknown strains—to ensure the most precise and comprehensive microbiome analysis available today. With science-backed insights and personalized recommendations, GutID™ empowers you to optimize your digestion, immunity, and overall well-being.

HairSmart Inc.

Booth #931

675 Alpha Drive Ste E Highland Heights, OH 44143

USA

Ph: (216) 543-8169

Email: marketing@myhairsmart.com www.myhairsmart.com

HairSmart has combined Modern Western Technology of Low-Level Light Therapy + Ancient Eastern Science of Ayurveda + High Performing Nutritional Superfoods to create COMPLETE hair growth solutions for distinct needs.

Healthgevity

Booth #538

21a Allen Avenue

Allenhurst, NJ 07711

USA

Ph: (833) 940-4898

Email: support@healthgev.com

www.healthgev.com

Healthgevity is a leader in pioneering science, dedicated to unlocking the full potential of orally bioavailable peptides, proteins, and other natural bioactives. With a relentless focus on innovation, our mission is to enhance longevity, optimize healthspan, and elevate overall well-being. We collaborate with top doctors and scientific researchers to translate groundbreaking discoveries into advanced, clinically backed nutraceuticals. Every product is meticulously formulated to deliver the most effective, science-driven solutions, empowering individuals to take control of their health and longevity.

Harmony Care LLC

Booth #132

8940 Sunriver Meadows Avenue

Las Vegas, NV 89148

USA

Ph: (562) 338-6995

Email: expo@harmonycarellc.com

www.harmonycarellc.com

health and wellness products

Heads Up

Booth #1128

4400 N Scottsdale Road Ste 9445 Scottsdale, AZ 85251

USA

Ph: (602) 671-3074

Email: info@headsuphealth.com

www.headsuphealth.com

In today’s era of connected health, decisions happen in real-time using advanced digital health technology and actionable biofeedback. Our all-in-one platform integrates wearables, lab results, EHR data, and selftracking tools to give practitioners a 360° view of patient health. With customizable dashboards and automated reporting, it’s designed for concierge doctors, integrative and functional medicine practices, longevity programs, research teams, and digital health innovators. Streamline workflows, monitor trends, and intervene at the right moments with ease— empowering data-driven care for better outcomes.

Healthie

9450 SW Gemini Drive

Beaverton, OR 97008

USA

Ph: (206) 617-0534

Email: Hello@gethealthie.com

www.gethealthie.com

Healthie provides infrastructure to power the next generation of healthcare delivery. Healthie’s APIfirst EHR, Scheduling, and Engagement solutions, coupled with the Healthie Harbor - a marketplace of integrations, makes it easy for organizations of any size to launch and scale care delivery services.

Hue Light USA

146 Rock Hill Drive PO Box 960

Rock Hill, NY 12775

USA

Ph: (845) 796-9951

Email: info@huelightusa.com

huelightusa.com

Here at Hue Light, our goal is to provide support to help manage a healthy immune system for those of all ages. We provide therapeutic device healing and pain relief of all degrees, no matter how mild or severe the condition may be. We work tirelessly in research and development, studying the latest technologies, current market trends, and scientific findings to help you get one step closer to experiencing the healing and wellness you’ve been searching for.

Booth #120

Booth #1115

Humann

Booth #801

1250 S. Capital of TX Hwy.1-360 Austin, TX 78746

USA

Ph: (512) 488-4477

Email: professional@humann.com www.pro.humann.com

Since 2010, humann has excelled in pushing the boundaries of cardiovascular science to change how we look at our health. Founded on the groundbreaking Nobel-Prize winning discovery of Nitric Oxide, humann is committed to supporting our cardiovascular health through innovative, unique supplements and wellness solutions that are both easy to incorporate into your daily routine and effective for your body. A leader in plant-based cardiovascular health, humann’s products are widely used by physicians and health care professionals, athletes, and consumers.

Hyperion Medical

Booth #122

15932 Midway Road Dallas, TX 75001

USA

Ph: (877) 275-5691

Email: info@smartabi.com

www.hyperionmed.com

Hyperion Medical Technologies Inc. delivers cutting-edge diagnostic and therapeutic systems, specializing in ABI testing and advanced shockwave treatments. With a focus on wound care, podiatry, and pain management, our mission is to equip healthcare providers with superior tools that improve outcomes and streamline practices, transforming patient care across diverse medical settings.

imaet Bioenergetic Technology

Booth #435

1326 New Seneca Turnpike Ste A4

Skaneateles, NY 13152

USA

Ph: (315) 756-6111

Email: communications@imaet.com

www.imaet.com

imaet Bioenergetic Technology is a leading innovator in bioenergetic stress management and epigenetic healing, dedicated to enhancing the flow of subtle biocellular energies through advanced technology. Our flagship product, the imaet System, utilizes quantum field communication to interact with the body’s cellular network, promoting optimal energetic balance and epigenetic wellness.

InBody

Booth #129

13850 Cerritos Corporate Drive Unit C

Cerritos, CA 90703

USA

Ph: (323) 932-6503

Email: convention@inbody.com www.inbody.com

For over 25 years, InBody has provided in-depth insights for healthcare providers, revolutionizing how body composition and blood pressure are monitored. In seconds, InBody’s non-invasive tests capture essential data that allows you to individualize treatment plans for hormone replacement therapies. You can use InBody’s measurements to discover leading indicators of obesity and metabolic syndrome, such as changes in muscle mass, body fat, visceral fat, intra- and extracellular water, cellular health, and blood pressure.

Ironsail Pharma

1508-01 Cross Bay Blvd

Howard Bch, NY 11414

USA

Ph: (516) 740-0921

Email: astrid@ironsailpharma.com www.ironsailpharma.com

Ironsail Pharma gives you access to a network of compounding pharmacies, and helps to optimize your pharmaceutical services to best serve your patients, and improve your internal workflow.

2299 Summer Street Ste 1095

Stamford, CT 06905

USA

Ph:

Email: hello@jona.health www.jona.health

Jona is a microbiome technology company that brings cutting-edge microbiome science to clinicians, empowering them to provide personalized, datadriven care. Unlike standard pathogen panels, Jona analyzes the full microbiome ecosystem, offering deeper insights into gut health, metabolism, immunity, and inflammation. Our AI-driven platform interprets microbiome profiles in the context of thousands of studies, identifying microbiome signatures linked to various conditions. Leveraging digital twin technology, Jona generates tailored recommendations for diet, supplements, and lifestyle interventions—helping clients optimize their health.

Booth #747

Jona Booth #1102

KBMO Diagnostics

Booth #100

4 Business Way

Hopedale, MA 02332

USA

Ph: (617) 933-8130

Email: info@kbmodiagnostics.com kbmodiagnostics.com

KBMO Diagnostics is a fully integrated medical diagnostics company offering a patented multi-pathway food sensitivity test which now includes our unique Gut Barrier Panel via fingerstick or blood draw. The test measures; food sensitivities, via IGG 1-4, Inflammation via C3d and Gut Permeability via Candida, Zonulin, Occludin, and LPS. The Food Inflammation Test (FIT) measures up to 176 foods, colorings, and additives. We provide a color-based report, meal plan and mobile app for each patient and treatment protocols for providers.

Klima Sorrell Insurance Group

Medical Professional Liability Insurance Booth #546

2160 Duck Slough Blvd Ste 102 Trinity FL, 34655

USA

Ph: (877) 961-6110

Email: info@sorrellinsurance.com

www.sorrellinsurance.com

Klima Sorrell Insurance Group has been providing Medical Malpractice Insurance to the health care community since 1989. We have achieved key agent status with four of the nation’s largest insurance carriers,and grown to become one of the most directly appointed independent agencies in the industry. We will help to streamline your practice by providing employee management products, including health insurance, payroll and employee benefits packages. Our agency will work to match the needs of your practice with the top carriers in the industry, while providing the most affordable premium.

10927 Wonderland Trail Dallas, TX 75229

USA

Ph: (719) 694-1970

Email: info@luxmedtransition.com www.luxmedtransition.com

LuxMed Transition Strategies is the premier partner for aesthetic and wellness practices exploring seamless practice transitions. As an affiliate company of Professional Transition Strategies, LuxMed brings unparalleled expertise in practice sales, mergers and acquisitions to the aesthetics and wellness industry. Whether owners are considering retirement or expansion, LuxMed offers customized, expert solutions designed to optimize outcomes and secure the future of each practice.

LVLUP Health

22 Coolong Crescent

Carrara,Queensland 04211 AUS

Ph: 61 427 371 969 (whatsapp)

Email: info@lvluphealth.com www.lvluphealth.com

LVLUP Health leads the way in health optimization, combining cutting-edge science with traditional and naturopathic medicine to deliver groundbreaking, highly efficacious peptide and nutraceutical supplementation. Known for our commitment to quality, purity, and bioavailability, LVLUP Health empowers individuals and practitioners to elevate wellness practices with targeted solutions. These innovative formulations address prevalent health concerns, enhance patient outcomes, and fast-track results with convenient “protocols in a bottle” designed to simplify therapeutic interventions.

Klotho Skin

Booth #746

655 Redwood Highway Ste 160 Mill Valley, CA 94941

USA

Ph: (415) 400-5447

Email: Gail.Humble@klothoskin.com www.klothoskin.com

Klotho Skin is a biotech company introducing an innovative skin care line which uses genetically modified stem cell which have an increase in the anti aging gene/protein Klotho production. Cellular studies show a decrease in 40% reduction in DNA damage from daily UVA . Our clinical studies have shown a 36.5% reduction in dyschromia, 35% reversal in photo-damage, and 30% reduction of wrinkles and improvement in texture in just three months. Klotho skin is preventative, regenerative and protective.

Booth #344

970 W 190th Street Ste 435

Torrance, CA 90502 USA

Ph: 81 80 2918 4927

Email: info@mandausa.com mandausa.com

The Manda brand is over 300 years old. Originally a high quality sake brewery in southern Japan, the company now employs its traditional fermentation expertise with modern technology to create fermented products which contribute to the wellness of people and the earth. Now, we(Manda USA) are exporing our product and fermentation benefit to support maintainin your welness.

LuxMed Transition Strategies

Booth #734

Booth #430

Manda Fermentation USA, Inc

MaxGen Labs

Booth #647

170 E Main Street Ste D

Hendersonville, TN 37075

USA

Ph: (832) 683-1574

Email: accounts@maxgenlabs.com

www.maxgenlabs.com

MaxGen Lab was created by practicing physicians to provide a safe, accurate, and easy-to-understand way for people to learn about their bodies. Our reports are based on cutting-edge research, trusted by hundreds of physicians worldwide, and have received rave reviews and success stories. All of our reports contain actionable steps with easy-to-understand and implement results. Our simple and precise DNA tests have helped thousands of individuals make more proactive choices toward optimal health and healing.

McArthur Insurance Agency, Inc.

Booth #1042

12605 Ulmerton Road

Largo, FL 33774

USA

Ph: (727) 593-0398

Email: MikeM@McarthurAgency.com

www.mcarthuragency.com

McArthur Insurance Agency, has been a trusted provider of malpractice insurance solutions for more than 30 years. The agency works with more than 35 carriers nationwide to offer competitive rates and tailored coverage for healthcare professionals and clinics. McArthur Insurance Agency is known for its expertise in professional liability insurance, helping medical practitioners secure comprehensive protection.

MD PracticeFlow

Booth

#336

1470 Biscayne Blvd

Miami, FL 33132

USA

Ph: (305) 297-3441

Email: info@wellnessclinicmarketing.com mdpracticeflow.com

At our agency, we are a dedicated team of skilled software and medical marketing professionals committed to helping medical practices enhance their patient base and boost revenue. We specialize in providing software automation and marketing services tailored specifically for medical wellness practices that offer cash-based treatments aimed at restoring optimal hormone levels and improving overall well-being. With over a decade of experience, we understand that many medical businesses struggle with lead management and patient retention.

Med Results

Booth #938

1111 N Brand Blvd Ste 350 Glendale, CA 91202

USA

Ph: (310) 707-3223

Email: info@med-results.com med-results.com

Med Results, a top leading provider of aesthetic medical equipment, showcases Plexr Plus at A4M Spring Congress 2025—a noninvasive skin tissue removal device using innovative plasma technology. Our collaboration with the A4M Spring Congress 2025 underscores our commitment to advancing the aesthetic industry. We aim to connect with professionals prioritizing exceptional results, providing pioneering technologies for cosmetic procedures. Explore the future of aesthetic medicine with Med Results at A4M Spring Congress 2025.

edeia

Designed for Clinicians

7 W. Figueroa Street Ste 215 Santa Barbara, CA 93101

USA

Ph: (800) 433-4609

Email: info@medeia.com www.medeia.com

Since its inception in 1992, Medeia Inc has been on the forefront in the manufacture and distribution of Neuro Diagnostic and Heart Rate Variability / ANS products. Medeia Inc specializes in the development of state of the art biometrical software and hardware products intended to monitor physiology for research and educational purpose.

2700 Hall Place Longview, TX 75604

USA

Ph: (855) 212-1997

Email: Themedicaltechdp@gmail.com themedicaltech.net/

We provide top-quality medical wellness services, The technical team of Medical Tech Services produces revolutionary medical devices for the currently operating healthcare industry and even offers optimum quality services to customers. Our range of products includes medical devices like Ozone sauna ,First Smart Float Tank,Float Pod, Narrowband UVB Phototherapy, Professional Red Light Therapy Devices, PDT LED Light Therapy.

Medeia

Booth #1030

Medical Tech

Booth #827

Metagenics

Booth #1000

25 Enterprise Ste 200

Aliso Viejo, CA 92656

USA

Ph: (800) 692-9400

Email: Info.customerservice@metagenics.com www.metagenics.com

Metagenics has spent over 40 years dedicated to enhancing lives through scientifically-proven nutraceuticals. Our whole-body approach addresses the root causes of health concerns, utilizing precision science to create high-quality, rigorously tested supplements. Trusted by healthcare practitioners globally, our products evolve with your nutritional needs, working swiftly to support your health at every stage of life. At Metagenics, we harness the best of nature to help you live happier, healthier lives.

Microbiome Labs

Booth #519

77 Perry’s Chapel Church Road Ste 210 Franklinton,, NC 27525

USA

Ph: (904) 940-2208

Email: info@microbiomelabs.com

www.microbiomelabs.com

Microbiome Labs is a company focused on improving health outcomes through the modulation of the gut microbiome. The company was built upon three major pillars: clinical research, education, and product innovation. This unorthodox approach is far and away what continues to set Microbiome Labs apart from the rest of the supplement industry. We strive to create unique and effective solutions that help practitioners change lives all over the world.

2360 Campbell Creek Blvd Ste 530 Richardson, TX 75082

USA

Ph: (214) 945-3044

Email: contact@mnmlaesthetics.com www.mnmlaesthetics.com

MNML Aesthetics is a premier partner for med spas, doctors, and aesthetic medical businesses, offering cutting-edge devices, expert training, and unparalleled support. With nearly a decade of experience, we empower clients to stay ahead in the ever-evolving world of aesthetics. Based in Richardson, TX, our state-of-the-art facility provides a showroom, training center, and more. Dedicated to blending beauty and wellness, MNML Aesthetics delivers tailored solutions to help clients thrive and grow.

10455 Riverside Drive Ste 100 Palm Beach Gardens, FL 33410

USA

Ph: (352) 871-3803

Email: allergy@molekule.com molekule.com

Air quality is the most overlooked supplement for health and longevity. Molekule’s PECO technology surpasses HEPA, destroying toxic pollutants like mold, bacteria, and VOCs. The result? Better respiratory health, fewer allergies, improved cognition, and deeper sleep. Reduce indoor toxicity and breathe cleaner with Molekule.

miraDry, Inc.

Booth #1120

100 Bayview Circle Ste. 360 Newport Beach, CA 92660

USA

Ph: (855) 647-2379

Email: marketing@miradry.com www.miradry.com

miraDry is an innovative, FDA-cleared treatment that provides a long-lasting solution for excessive underarm sweat and odor. Safe, immediate and non-surgical, miraDry effectively reduces sweat and odor glands in the underarms, offering lasting results and 90% patient satisfaction. miraDry remains the first and only of its kind and is available globally, with more than 500,000 patients treated to date and growing. Learn more at miraDry.com.

MyAdvice

1850 West Ashton Blvd Ste 500

Lehi, UT 84043

USA

Ph: (435) 575-7470

Email: sales@myadvice.com www.myadvice.com

MyAdvice empowers practice owners to increase their revenue by attracting and retaining more patients through digital marketing. Our platform enables hands-on control and visibility into the performance of online marketing activities, backed by 20+ years of best practices and expertise. Our six-stage Pyramid of Success™ provides a proven step-by-step plan for how and when to implement growth-oriented marketing tactics for greatest impact, including website design, local directories, client reviews, social media, search engine optimization (SEO), and paid advertising.

MNML Aesthetics

Booth #110

Molekule

Booth #1037

Booth #934

Mymycolab, LLC

Booth #914

17849 Hunting Bow Circle Ste 102 Lutz, FL 33558

USA

Ph: (561) 631-3901

Email: spenaranda@mymycolab.com mymycolab.com

MyMycoLab is a laboratory specializing in blood serum antibody testing for mycotoxins. Our laboratory tests for 14 different mycotoxins for both IgG and IgE antibodies. This is the most precise and accurate method to determine if a person has been exposed to mycotoxins.

National Hair Loss Medical Aesthetics

Booth #342

7000 E. Shea Blvd Ste E-110 Scottsdale, AZ 85254

USA

Ph: (602) 283-2355

Email: info@nhlma.com www.nhlma.com

NHLMA was founded to be a 1stop shop for all hairloss services. We offer comprehensive services for women, men, and children, including telemedicine for personalized follow-ups and progress tracking. Specializing in unexplained hair loss due to autoimmune, thyroid, stress, postpartum, or pregnancy factors, NHLMA provides tailored solutions through a team-based approach. We also offer educational courses for providers on integrating hairloss programs into their practice. Our experts offer 1:1 care, making telehealth convenient and effective for restoring beauty and confidence.

NeuroScience

375 280th Street

Osceola, WI 54020

USA

Ph: (888) 342-7272

Email: customerservice@neurorelief.com www.neuroscienceinc.com

A better life starts with a healthy brain. And our passion is helping everybody understand and support their unique neuro-endocrine health with actionable information.__ As a family-owned leader in brain health since 2000, NeuroScience formulates impactful dietary supplement blends targeting the science behind sleep, stress, mood, energy, and cognitive health. We offer healthcare provider exclusive services to streamline supplement selection, including access to non-invasive laboratory testing for neurotransmitter and hormone activity. Wellness journeys start here.

Nordic Naturals

111 Jennigns Drive Watsonville, CA 95076

USA

Ph: (831) 566-6664

Email: ttrubey@nordic.com www.nordicpro.com

At Nordic Naturals, we’re committed to delivering the world’s safest, most effective nutrients essential to health. It’s what motivates us to ensure that all our products are research supported, expertly formulated, rigorously tested, proven effective, and best of all, great tasting. Transparency in supplement manufacturing is critical to your health and safety. Every Nordic Naturals product is tested to verify potency, purity, and freshness by certified laboratories.

NeuroAge Therapeutics

Booth #1044

135 Mississippi Street

San Francisco, CA 94107

USA

Ph:

Email: hello@neuroagetx.com www.neuroagetx.com

NeuroAge is revolutionizing brain health by reversing cognitive aging. The NeuroAge Test, the first of its kind, reveals your brain’s true age and predicts your risk of dementia over 30 years in advance. It includes a brain MRI, cognitive assessment, proprietary blood biomarkers, and genetic analysis. We offer clients personalized lifestyle recommendations based on the results. The NeuroAge Test is available in private clinics globally and directly to consumers.

Norsan Inc.

Booth #1046

444 Brickell Avenue Ste 700 Miami, FL 33131

USA

Ph: 49 151 2331 6647

Email: ilma.busilaite@norsan.de www.norsan-omega.com

We are a leading Omega-3 supplement brand, proudly recognized as the #1 choice in German pharmacies. Crafted with exceptional quality, purity, and sustainability, our clinically backed products support heart, brain, and overall health. Trusted by healthcare professionals and loved by consumers, we bring European excellence to the U.S. market. Available exclusively online, we ensure convenient access to premium Omega-3 solutions. Discover the trusted brand delivering health and well-being through science and innovation.

Booth #346

Booth #1021

North

Booth #831

250 Stephenson Highway

Troy, MI 48083

USA

Ph: (888) 274-3490

Email: sales@north.com www.north.com

Let North guide you to easier checkout and healthier profits. We know a thing or two about longevity. Since 1992, North has been committed to being the easiest payment technology company to do business with. Contact us today and we’ll help you take your payments and profits to a whole new level.

NuBioAge, LLC

Booth #1003

8144 Okeechobee Blvd West Palm Beach, FL 33411 USA

Ph: (855) 212-1997

Email: info@nubioage.com nubioage.com

We are a longevity science and wellness education network serving medical practitioners and allied health professionals focused on delivering patientcentric, evidence-based longevity medicine. Our mission is to evolve longevity care for better aging by providing the top medical minds of today with transparent, evidence-based knowledge, expert-quality, science-backed formulations, and physician-centric educational training events for learning how to deliver the clinical application of longevity medicine.

NuMedica

Booth #906

9503 E 55 Pl Tulsa, OK 74145

USA

Ph: (800) 869-8100

Email: mail@numedica.com www.numedica.com

NuMedica® is an NSF® GMP Certified, FDA registered company implementing the latest quality control standards in manufacturing and testing of our formulas. Our formulas are designed with active ingredients for higher performance along with advanced nutrient delivery methods and Enhanced Absorption Technologies™ offering value through increased bioavailability. We rely on our extensive and diverse network of healthcare practitioners, industry opinion leaders, educators and university partners to validate formula performance with clinical results.

5414 Hwy.12

Maple Plain, MN 55359

USA

Ph: (763) 656-8728

Email: joel@nutri-dyn.com

NutriDyn.com

For over 50 years, NutriDyn has partnered exclusively with healthcare practitioners to deliver clinically proven supplements that elevate patient care. With practitioner-focused education, dedicated support, and innovative formulas, we empower you to thrive in your practice and achieve better patient outcomes. At NutriDyn, we’re more than a trusted supplement provider—we’re a committed partner in your journey to transform lives through functional nutrition and shape the future of health and wellness together. Discover more at NutriDyn.com.

Nutritional Frontiers

3191 Washington Pike Bridgeville, PA 15017 USA

Ph: (412) 922-2566

Email: info@nutritionalfrontiers.com nutritionalfrontiers.com

Nutritional Frontiers is a family-owned, faith-based Pittsburgh company with a committed mission to Making the World Healthy. We source the best ingredients and create unique formulations to Improve Patient Outcomes and Increase Practice Profits. Every nutraceutical formulation is produced in an FDA inspected cGMP certified manufacturing facility. We partner with our clients in every way to create better outcomes for their patients and improve the profitability of their practices. Trust is the foundation of our company.

Olympia Pharmaceuticals

Booth

#301

6700 Conroy Road STE 155

Orlando, FL 32835 USA

Ph: (407) 250-4000

Email: inquiries@olympiapharmacy.com www.olympiapharmacy.com

Olympia Pharmaceuticals is the nation’s leading FDA registered 503B outsourcing facility. Olympia specializes in weight loss, dermatology, IV nutritional therapy, hormones, erectile dyfunction and more. With our two separate, state-of-the-art facilities, Olympia supports both patient-specific and office-use needs across the U.S., enabling our customers to comply with all national and state regulatory requirements while having the convenience of a single-source pharmacy partner.

NutriDyn

Booth #227

OMNIWAVE™

Booth #713

2980 NE 207th Street Ste 503

Aventura, FL 33180

USA

Ph: (833) 666-4928

Email: info@omniwave.com

www.omniwave.com

At OMNIWave™, we believe in effective, non-invasive treatments that go beyond medications and surgical procedures. Our electrohydraulic focused shockwave device provides a pain-free solution for chronic discomfort, tissue regeneration, collagen production and much more. OMNIWave™ is more than just a device—it’s a complete system dedicated to provider success through comprehensive training, business strategies, ongoing support, and a growing community of innovative providers. Visit booth #713 to learn more about OMNIWave™ and experience it firsthand!

OrganoLeaf

Booth #728

1720 Diplomacy Row Orlando, FL 32809 USA

Ph: (407) 730-4137

Email: info@organoleaf.com

www.organoleafwholesale.com

OrganoLeaf is a leading manufacturer and wholesale supplier of healthy, sugar-free nutraceutical gummies, delivering therapeutic doses of high-quality ingredients. We specialize in white-label solutions, using allulose and pectin to create delicious, functional gummies without sugar. Our GMP-certified facility in Orlando, FL, ensures the highest standards of safety, quality, and consistency. Whether you’re looking for private-label manufacturing or bulk wholesale, OrganoLeaf is your trusted partner for innovative, science-backed nutraceutical products.

Ortho Molecular Products

Booth #

219

540 W. Northwest Hwy Second Floor Barrington, IL 60010

USA

Ph: (815) 206-6541

Email: l.grendel@ompimail.com

www.orthomolecularproducts.com

For over 35 years, Ortho Molecular Products has partnered exclusively with health care providers to deliver nutritional solutions of the highest efficacy. The most trusted voices in health care put their trust in our products to help patients get better, faster. Our commitment to science, careful raw ingredient selection, and strict quality standards goes into every supplement we formulate. To learn more, visit www. orthomolecularproducts.com or call 1-800-332-2351.

OxyHealth Hyperbarics

10719 Norwalk Blvd

Santa Fe Springs, CA 90670

USA

Ph: (562) 906-8888

Email: info@oxyhealth.com www.oxyhealth.com

OxyHealth has forever changed the way the medical industry practices hyperbaric therapy. Since our inception, we are devoted to providing quality and brilliantly safe portable hyperbaric chambers to physicians, professional athletes, wellness centers, and families. All OxyHealth chambers are designed for patients to easily self-treat, which has fostered a cutting-edge trend in hyperbaric technology.

6833 S. Dayton Street Ste.1016 Greenwood Village, CO 80112 USA

Ph: (407) 793-9254

Email: aneff@patientnow.com www.patientnow.com

PatientNow is the industry leader in providing integrated EMR, practice management, patient retention, memberships, and before & after photo solutions for the modern elective medcial practice.

PD Labs Compounding Pharmacy

1513 East New Hope Drive Bldg. E Leander, TX 78641 USA

Ph: (512) 219-0724

Email: info@pdlabsrx.com pdlabsrx.com

At PD Labs Pharmacy in Cedar Park, we are your trusted partner in health, specializing in compounded medications for Lyme, mold, hormonal, thyroid, cognitive, and men’s and women’s health. With cutting-edge LPT technology and personalized care, we go beyond filling prescriptions—we transform lives. Dedicated to innovation, excellence, and community well-being, we lead in advanced solutions and proudly ship nationwide. Discover the difference and take charge of your health with PD Labs.

PatientNow

Personalized and Compounded Nutrients

Booth #744

68994 North Pine Street Sisters, OR 97759

USA

Ph: (541) 549-0333

Email: info@personalized-nutrients.com www.freedomtoformulate.com

Personalized Nutrients empowers practitioners by allowing for creating personalized nutrition supplements, custom-made to meet individual patient needs. Practitioners create custom label supplements that have been designed to maximize individual patient outcomes by harnessing the potential of personalized nutrition. Compounded Nutrients is for healthcare professionals looking to design their own high-quality custom private label supplements in manageable quantities. Bring your custom supplement ideas to real life formulas and express your clinical opinion.

Pharmanex / Get Healthy USA

Booth #1007

2728 Wymberly Drive Jupiter, FL 33458

USA

Ph: (561) 972-1122

Email: drsteve@gethealthyusa.com gethealthyusa.com

Get Healthy USA is the leading distributor of Pharmanex, offering science-backed wellness solutions and ageLOC technology to support healthy aging. We’ve developed the most effective systems for practice integration, helping healthcare professionals enhance patient care with cuttingedge nutraceuticals. We provide the only device that accurately measures carotenoid antioxidant status, ensuring real-time insights into health. Featured on Discovery Channel and soon in the BioHack Yourself documentary on Amazon, we’re at the forefront of innovation in health, vitality, and longevity.

PNOE, Inc.

67 Maplewood Street

Malden, MA 02148

USA

Ph: (650) 670-4450

Email: info@pnoe.com

pnoe.com

PNO_ is a breakthrough in health and fitness, making breath analysis—a key tool for understanding metabolism, fitness levels, and overall health—easily accessible to health professionals. Along with its special software and expert team support, PNO_ helps health experts give personalized advice on diet, workout, and lifestyle. It simplifies identifying health issues and offers custom recommendations. PNO_ is more than just a tool—it’s a complete system that improves client care and helps health and fitness practices stand out.

Power2Practice Booth #337

601 S. Saginaw Street 5th Fl Flint, MI 48502

USA

Ph: (331) 645-2310

Email: sales@power2practice.com power2practice.com

Power2Practice is specifically designed for functional and integrative medicine. With features such as customized note templates, cash-based billing module/superbills, specialty lab integrations, Fullscript interface, Power2Practice gives you all the EMR capabilities you expect, plus the specialized features you need. Our intuitive patient portal facilitates patient communication, online scheduling, appointment reminders and much more. Plus, with the addition of our newly released Televisit module, Power2Practice streamlines the efficiencies of the charting, front office and patient experience.

Physicians Lab Inc

Booth #1119

4850 T Rex Avenue Ste 150 Boca Raton, FL 33431 USA

Ph: (877) 326-5969

Email: info@physicianslab.com physicianslab.com

Physicians Lab, located in Boca Raton, FL, provides convenient at-home lab testing that is precise, reliable and timely. We serve physicians focused on integrative medicine and wellness for an aging population by shipping easy-to-use lab kits to patients’ homes. Urine hormone and micro nutrient testing is the primary focus of our Lab.

Professional Health Products

Booth #643

2104 Babcock Blvd Pittsburgh, PA 15209

USA

Ph: (412) 760-1115

Email: hlord@phpltd.com www.phpltd.com

Cutting corners when it comes to quality is an all too common practice in the supplement industry. We at PHP have been committed to using the highest quality ingredients, backed by science, in our formulations since our beginning in 1978. Our integrity and ingenuity goes into every product in our comprehensive line; making the partnership we have with clinicians above industry standard.

Progressive Labs

Booth #943

3131 Story Road West Irving, TX 75038

USA

Ph: (972) 518-9660

Email: sales@progressivelabs.com www.progressivelabs.com

For over 50 years Progressive Labs has been dedicated to delivering science based nutraceutical products that maximize the potential for health and wellness, providing nutritional support your patients need. We are a GMP and UL certified manufacturer of 200+ products that can be private labeled. Our in-house graphics team will create and print your personalized label. We also do contract manufacturing if you would like to create your own formula.

Protocol For Life Balance

Booth #646

244 Knollwood Drive Bloomingdale, IL 60108

USA

Ph: 877-776-8610

Email: sales@protocolforlife.com

www.protocolforlife.com

Protocol For Life Balance is a well-researched, potent, and efficacious brand of high-quality dietary supplements and natural products sold exclusively through licensed healthcare practitioners. Protocol For Life Balance offers many unique formulas and products, that come with a money -back guarantee if any patient is less than 100% satisfied. Our mission is simply to provide quality products that lead to healthy patients and satisfied physicians. Family Owned and Operated. www.protocolforlife.com 877-776-8610

Promise Pharmacy

Booth #447

31818 US Hwy 19N Palm Harbor, FL 34686 USA

Ph: (727) 772-0500

Email: info@promisepharmacy.com www.promisepharmacy.com

Promise Pharmacy is an independent compounding pharmacy dedicated to producing quality sterile and non-sterile drug products, working with practitioners of functional, integrative and regenerative medicine to serve the needs of their patients. Our focus is on providing safe, effective, high-quality compounded medications and superior customer service for hormone optimization, weight management, wellness and age-management, dermatology and ophthalmology. We’re licensed in 41 states and territories, including the District of Columbia and the US Virgin Islands.

ProRx, LLC

Booth #527

619 Jeffers Circle Exton, PA 19341

USA

Ph: (850) 554-7809

Email: Sales@prorxpharma.com www.prorxpharma.com

ProRx is a FDA-registered 503B outsourcing facility focused on wellness and longevity. Our expanded facility is prepared to meet the growing demand for medication, both now and in the future. We are dedicated to ensuring the highest standards of safety and efficacy for all of our products. At our booth, discover our unique approach towards the ongoing drug-shortage crisis, including our expertise in producing medications and formulations in health, wellness, and longevity. We service clinical centers, hospitals, and pharmaceutical companies.

Encapsulations

490 Boston Post Road

Sudbury, MA 01752 USA

Ph: (800) 753-2277

Email: customerservice@PureEncapsulations. com

www.pureencapsulationspro.com

We’re Pure Encapsulations®, the #1 most recommended professional supplement brand by healthcare professionals.1 Our products are backed by verifiable science, tested for purity and potency, and formulated using high-quality, pure ingredients FREE FROM unnecessary additives, and many common allergens. That’s goodness encapsulated. 1. Among U.S. healthcare professionals surveyed who recommend specific professional supplement brands; Nutrition Business Journal® Practitioner Survey 2016, 2020, 2023

Pure Peptide Solutions

Booth #334 / 335

993 S. Santa Fe Avenue c 90 Vista, CA 92083

USA

Ph: (877) 737-8133

Email: sales@purepeptidesolutions.com www.purepeptidesolutions.com

Pure Peptide Solutions is your premier direct-tomanufacturer source for top-quality peptides, APIs, co-enzymes, and more. We partner exclusively with FDA-inspected manufacturers, to ensure the highest purity and efficacy standards for products like Semaglutide, Tirzepatide, and NAD+. We serve manufacturers, 503A and 503B compounding pharmacies, med spas, clinics, researchers, and healthcare professionals - providing a reliable supply chain, competitive direct pricing, and expert guidance. FDA-Approved Peptides & APIs | Reliable Supply Chain | Competitive Pricing | Expert Support

Purepell

Booth #742

5 Cowboys Way Ste 300 Frisco, TX 75034

USA

Ph: (469) 214-0816

Email: rhettrichardson@ht-ca.com HT-CA.com

Purepell is a premier provider of turnkey Bioidentical Hormone Replacement Therapy (BHRT) solutions for medical practices. Our comprehensive program equips healthcare providers with world-class training, ongoing support, and powerful marketing tools to seamlessly integrate BHRT into their practice. At Purepell, we are committed to helping practitioners transform lives by providing a proven system that enhances patient care and drives practice growth. We also connect patients seeking hormone optimization with certified Purepell providers, ensuring they receive expert care from trained professionals.

#547

356 E 20 S American Fork, UT 84003

USA

Ph: (385) 412-1726

Email: nate@qest4.com qest4.com

The world leader in Bioenergetic testing. We provide holistic and wellness practitioners with the tools and resources needed to better help their clients and their communities.

PUR-FORM

Booth #737

3600 FAU Blvd Ste 101 Boca Raton, FL 33431 USA

Ph: (561) 368-1880

Email: ebo2sales@purformhealth.com purformhealth.com

PUR-FORM, led by renowned regenerative medicine expert Dr. Joseph Purita, is the world leader in EBO2 (Extracorporeal Blood Oxygenation and Ozonation) training. This groundbreaking treatment oxygenates and ozonates 5-7 liters of blood over 60-90 minutes, effectively removing inflammatory proteins, toxins, and impurities to enhance overall health. We provide expert-led, hands-on training directly in clients’ clinics, ensuring seamless integration. PUR-FORM is pioneering the future of regenerative health through science, innovation, and education.

Push Patch

3683 Garden Court Grove City, OH 43123 USA

Ph: (951) 840-8769

Email: orders@pushpatch.com www.pushpatch.com

Push Patche uses an Iontophoresis patch that is a proven drug delivery technology that dates back to the mid-18th century. Think of it as an “IV without a needle.” By using a mild electric current, iontophoresis enables molecules to penetrate the skin and enter the bloodstream. With modern advances in microprocessor technology, our Push Patch units are now wireless, easy to apply, and convenient for patients to wear.

USA

N. San Vicente Blvd 3rd

CA 90211

Ph: (424) 257-3977

Email: contact@qualiphy.me qualiphy.me/

Qualiphy connects medical practices with licensed providers for instant video exams, prescriptions, and medication shipping. We specialize in safe, compliant Good Faith Exams (GFEs) for med spas across 48 states and D.C., ensuring state-specific compliance. Our exams require no scheduling and are available 7 days a week, 365 days a year, for $27.99 per exam. We also support weight loss prescriptions with medication shipping and offer online urgent care services, all designed to operate seamlessly on behalf of your practice.

6701 Carnegie Avenue Cleveland, OH 44103

USA

Ph: (678) 438-7888

Email: chlcustomerserviceemails@ questdiagnostics.com www.clevelandheartlab.com

Cleveland HeartLab offers innovative, scientifically proven, and medically relevant biomarkers that are predictive of cardiovascular risk. We offer inflammatory and other advanced biomarker testing that practitioners from across North America, Europe and Asia use in the management and prevention of heart disease. Our Mission Aid clinicians in identifying risk and reducing cardiovascular events. Our Vision To be the premier cardiovascular testing provider. Our Values Evidence-based science and clinical testing Superior quality Solutions-oriented attitude Integrity in all we do

Booth #901

Quicksilver Scientific

1960 Cherry Street

LOUISVILLE, CO 80027

USA

Ph: (303) 531-0861

Email: support@quicksilverscientific.com

www.quicksilverscientific.com

Quicksilver Scientific® is a leading manufacturer of advanced nutritional systems with a focus on detoxification. We specialize in superior liposomal delivery systems and heavy metal testing to support optimal health. Our advanced liposomal supplements are highly absorbable and support the body in the elimination of the broad range of toxins we’re exposed to. We are passionate about health and well-being and are committed to improving the lives of everyone we touch.

Refine USA®

3521 Leonard Ct.

Santa Clara, CA 95054

USA

Ph: (866) 364-0963

Email: hello@regenere.com www.regenere.com

Regenere is rooted in scientifically grounded skincare, providing customized formulas that visibly rejuvenate the skin at the cellular level.

Ph: (866) 590-5533

Email: sales@refineusa.com

www.refineusa.com

RefineUSA® is a leader in advanced aesthetic device manufacturing and distribution, offering cutting-edge solutions for medical and aesthetic professionals. With two decades of industry expertise, our portfolio includes FDA-cleared technologies such as the Rejuvapen NXT® Microneedling System, PureSpin PRP®, and FaceLITE LED Therapy— all designed to optimize clinical outcomes and practice profitability. RefineUSA® is committed to innovation, safety, and results-driven performance.

Regenative Labs

Booth #343

1700 West Main Street Ste 500 Pensacola, FL 32502

USA

Ph: (800) 891-3452

Email: info@regenativelabs.com

www.regenativelabs.com

Regenative Labs’ mission is to facilitate predictable patient outcomes by providing the highest quality human tissue allografts available. With the goal of addressing the root cause rather than masking pain, Regenative Labs’ birth tissue allografts provide a nonaddictive, non-invasive option for patients. Our stateof-the-art production facility is in Pensacola, Florida. We spare no expense when it comes to the technology, we insist is necessary to produce the quality regenerative products we expect for our partners.

Researched Nutritionals

#326 PO Box 224

Olivos, CA 93441 USA

Ph: (805) 693-1802

Email: customerservice@ researchednutritionals.com

www.researchednutritionals.com

Researched Nutritionals® is dedicated to creating professional grade, research-based formulations that are designed to promote energy and vitality and are supported by ongoing clinical trials to demonstrate efficacy. With products formulated with multiple mechanisms of action and focused on key areas of health such as mitochondrial function, immune support, detoxification, and cytokine health, Researched Nutritionals® is a leader within the dietary supplement market. We’re committed to providing powerful solutions, working directly with healthcare practitioners for their most challenging patient needs

Rush Pharmacy

#945

1977 Alafaya Trail Ste 1112

Oviedo, FL 32765 USA

Ph: (407) 542-0880

Email: sales@rushpharmacy.com rushpharmacy.com

Rush Pharmacy is a trusted compounding pharmacy specializing in customized medications to meet unique patient needs. We are committed to delivering the highest quality products backed by rigorous potency testing, competitive pricing, and fast shipping. Accredited and staffed by board-certified professionals, Rush Pharmacy provides unparalleled customer service and reliability for both providers and patients. Partner with us to ensure top-tier care with every prescription. Visit rushpharmacy.com to learn more.

Regenere

Rx Harmony (The JOI Group)

Booth #1135

45 Technology Parkway S STE 150 Peachtree Corners, GA 30092

USA

Ph: (770) 838-3570

Email: clinicalsupport@thejoigroup.com www.thejoigroup.com

Rx Harmony simplifies concierge programs that connect doctors and pharmacies, creating residual income while improving patient care. We handle prescription management, billing, and support, reducing the burden on practitioners and staff. Our programs include weight loss, hair restoration, sexual wellness, men’s and women’s health, and allergy management. As an extension of your practice, we streamline operations so you can restore your joy of practicing medicine. With Rx Harmony, we ensure predictable, recurring revenue and an enhanced “white glove” patient experience.

Sanoviv Medical Institute / Amarevita SC

Booth #1105

Crr Libre Tijuana Ensenada KM 39 Rosarito Beach,Baja CA 22710

Ph: (800) 726-6848

Email: SanovivInquiries@sanoviv.com www.sanoviv.com

Sanoviv Medical Institute is a fully-licensed integrative hospital, located in beautiful Rosarito Beach, Mexico, just South of San Diego. Their “whole-body” approach focuses on getting to the root cause of illness, not just treating symptoms; while immersing each guest in a healing environment. Sanoviv is the perfect solution for integrative patients who are not progressing or who need advanced, in-patient care. Each guest is assigned an integrative team including a medical doctor, nutritionist, psychologist, chiropractor, biological dentist, and bioenergetic specialist.

SENSIQ Nootropics & Adaptogens

Booth #242

61 W. Palisade Avenue

Englewood, NJ 07631

USA

Ph: (786) 713-1470

Email: hello@sensiqnootropics.com www.sensiqnootropics.com

SensIQ Nootropics + Adaptogens is a doctorformulated supplement brand designed exclusively for healthcare practitioners. Our clinically backed formulas target cognitive health, stress, sleep, and longevity using pharmaceutical-grade ingredients. SensIQ is trusted by medical professionals for its efficacy, safety, and HCP-exclusive distribution. We provide innovative solutions to support patient wellness, backed by science and designed for real-world results.

Sexual Wellness Centers of America

#102

6225 Colleyville Blvd Ste 100

Colleyville, TX 76034

USA

Ph: (214) 556-1300

Email: info@swcofusa.com

REGENmax.com

The only patented CURE for Erectile Dysfunction, no pills, no surgery.

#627

1439 Stuart Engals Blvd Mount Pleasant, SC 29464

USA

Ph: (843) 513-8306

Email: info.us@seca.com www.secambca.com

Individualized Data. Personalized Treatment. With our medically validated body composition analyzers, you gain the insights needed to make well-informed and effective therapeutic decisions. seca. Helping you help since 1840.

SFI Health

Booth #112

795 Trademark Drive

Reno, NV 89521

USA

Ph: (775) 850-8800

Email: customerserviceusa@sfihealth.com us.sfihealth.com

SFI Health is fueled by a collective belief that nature’s healing powers should be accessible to all while upholding our legacy of purity, potency, performance, and our flagship Ther-Biotic brand. With a rich history of over 200 years, SFI Health represents an unwavering commitment to quality, through extensive research, rigorous processes, and a commitment to sourcing quality ingredients. SFI delivers premium natural solutions that are renowned for their quality, credibility, and reliability by all who use them around the world.

seca

Booth

ShapeScale

Booth #1001

179 11th Street

San Francisco, CA 94103

USA

Ph: (415) 520-1316

Email: sales@shapescale.com business.shapescale.com

ShapeScale is a pioneering 3D body scanning system that offers unprecedented insights into an individual’s health and fitness. By capturing precise body measurements, composition data, and 3D visualizations, ShapeScale empowers health professionals and wellness businesses to deliver personalized, data-driven care and track patient progress with exceptional accuracy. As the company continues to push the boundaries of body scanning and health analytics, ShapeScale will transform the way we approach wellness and disease prevention, paving the way for a healthier future.

Shop C60, Inc.

Booth #438

4845 Pearl E. Circle #101 Boulder, CO 80301

USA

Ph: (303) 588-8608

Email: chas@shopc60.com www.shopc60.com

C60 Power is the premier manufacturer and distributor of the highest quality Carbon 60 (C60) based products. C60 is the most potent antioxidant that has been discovered to date. C60 Power products are manufactured to the highest standards using 99.99% Pure Sublimated C60 and infused into 100% Organic oils. All C60 Power products are 3rd Party Tested for purity and concentration. Ensuring the highest quality.

SilverCeuticals Inc.

Booth #912

1396 W. 200 South Ste 2C

Lindon, UT 84042

USA

Ph: (385) 212-4044

Email: sales@silverceuticals.com www.silverceuticals.com

SilverCeuticals harnesses cutting-edge nano-silver technology to develop a range of products including immune supports, beautifying cosmetics, oral care, and wound care technologies. Our advanced formulations are designed to address the specific needs of anti-aging professionals and their patients, promoting wellness and rejuvenation. With a commitment to global well-being, we strive to alleviate suffering by delivering innovative solutions that enhance health and vitality. Discover the power of SilverCeuticals to transform aging gracefully.

Booth

111 Terrace hall Avenue

Burlington, MA 01803

USA

Ph: (781) 202-5192

Email: enterprise@siphoxhealth.com www.siphoxhealth.com

SiPhox Health is transforming home diagnostics with cutting-edge microfluidics and silicon photonics. Our at-home test kits measure up to 50 key biomarkers for cardiovascular, metabolic, hormonal, and nutritional health, delivering clinically accurate results in days. We provide seamless cobranded solutions - handling logistics, testing, and technical setup - so partners can enhance client engagement and unlock new revenue streams.

Skingenuity, LLC

1301 Seminole Blvd Ste 175

Largo, FL 33770 USA

Ph: (727) 239-0005

Email: info@skingenuity.co www.skingenuity.com

SkinGenuity, LLC is a Florida-based company with a global footprint that developed a new form of regenerative medicine for aesthetics that can target specific tissue types and conditions. Its InterCell Messenger Technology™ incorporates two Nobel-Prize winning discoveries, bioengineered human growth factors and DNA repair enzymes. This new breakthrough is known as targeted regenerative medicine. The extensive clinical studies conducted and published in leading journals demonstrates the clear benefits of using targeted growth factors to treat specific conditions.

Strive Compounding Pharmacy

AZ 85233

Ph: (480) 626-4366

Email: Info@strivepharmacy.com strivepharmacy.com

In a realm dominated by pharmaceutical giants, Strive stands apart - a compounding pharmacy endeavoring for the personal side of healthcare. With that comes substantially greater scrutiny compared to “Big Pharma.” Scrutiny which we benchmark as a badge of excellence. We offer better medication, emphasizing safety, efficacy, and trust.

SiPhox Health

Summus Medical Laser

Booth #236

1185 West Main Street

Franklin, TN 37064

USA

Ph: (615) 595-7749

Email: info@summuslaser.com

summuslaser.com

Summus Medical Laser is a renowned leader in the laser therapy industry, providing laser products to over 51 countries that have resulted in millions of treatments performed worldwide. With a strong commitment to continued innovation, reliable stateside customer service, and growing brand awareness, Summus Medical Laser is devoted to empowering healthcare professionals to provide optimal patient care through the use of advanced laser therapy. To learn more, visit https://www.summuslaser.com.

Sciences

7975 N Hayden Road Ste C-101 Scottsdale, AZ 85258

USA

Ph: (212) 588-8805

Email: info@tasciences.com www.tasciences.com

T.A. Sciences® was founded in New York City by Noel Thomas Patton in 2002. T.A. Sciences® is dedicated to creating research-based, clinically tested products that help address telomere shortening through Telomerase Activation. T.A. Sciences® is widely recognized as the leader in the field of Telomere Biology. T.A. Sciences® spends over $1 million each year on leading edge scientific research, including doubleblind, placebo-controlled studies proving the safety and effectiveness of its premiere product TA-65®.

Tailor Made Compounding

200 Moore Drive

Nicholasville, KY 40356

USA

Ph: (859) 887-0013

Email: ataylor@tailormadecompounding.com www.tailormadecompounding.com

The Tailor Made Difference A Higher Standard of Care As experts in compounded medications, we provide custom wellness solutions to satisfy the unique needs of all types of patients. Our individualized treatments not only yield better health results - but maintain them for years to come. Visit us at www.tailormadecompounding.com to learn more about our integrative care treatments!

USA

Ph: (847) 640-9241

Email: 4health@tanita.com www.tanita.com

TANITA is a world leader in weight and body composition measurement. For more than 75 years the quality and accuracy of our products have made TANITA THE STANDARD by which other scales and body compositions monitors are measured. TANITA offers a full line of innovating, versatile, and easy to use scales and monitors used by people around the world.

Ph: (480) 331-3316

Email: info@Taxanista.com www.Taxanista.com

Taxanista provides specialized financial and strategic guidance that helps medical and wellness businesses flourish. According to satisfied professionals, their timely solutions, streamlined accounting, and customized tax strategies reduce stress and free owners to focus on patient care. With years of proven results, Taxanista is your go-to partner for sustainable, growth-oriented financial planning. Let them handle the numbers so you can handle your patients’ wellbeing. It’s financial therapy without the co-pay.

Tesseract Medical Research

Booth #1015

1370 Trancas Street Ste. 376

Napa, CA 94558

USA

Ph: (707) 690-0140

Email: concierge@tessmed.com www.TessMed.com

Tesseract Medical Research (TMR) is a biotechnology/ medical sciences company committed to providing the necessary support to make patient health management seamless and effective. TMR manufactures highquality supplements composed of pure botanical extracts and nutrients delivered through a proprietary delivery technology for optimal solubility, absorption and bioavailability. TMR’s formulations are ideal for cardiovascular, metabolic, gastrointestinal, neurological, musculoskeletal, immune, endocrine, hepatic, pulmonary and mood support. Proven molecules. Optimal delivery. Partner with us to transform patient care with superior health solutions.

Thaena

Booth #736

5951 E 18th Street

Vancouver, WA 98661

USA

Ph: (503) 506-8732

Email: info@thaena.com www.thaena.com

Thaena, pronounced | thay-nah |, is a femalefounded, Pacific Northwest-based company and the proud creators of ThaenaBiotic®, the world’s first stool-derived complex postbiotic supplement. Our mission is simple: To use science, radical innovation, and the microbiome to help people feel better. We believe in using the innate wisdom of the human body to shift the paradigms of medicine by expanding access to microbiome supports and putting postbiotics on the map.

Booth #847

881 Corporate Drive Lexington, KY 40503

USA

Ph: 1 888-909-3634

Email: support@trudiagnostic.com trudiagnostic.com

TruDiagnostic is a leading health data company with a focus on multi-omics and insights gained from the fluid epigenome. Established in early 2020, after development and build out of its 10,000 square ft state of the art laboratory with Illumina equipment and consultation it launched its first physician and patient test “TruAge”. Today, TruDiagnostic has built a premiere epigenetic database of DNA Methylation markers and covariates which is one of the largest in the world.

TheraLight LLC

Booth #743

175 1800 W. Ste 106 Lindon, UT 84042

USA

Ph: (501) 276-9495

Email: marylou@theralight.com

theralight.com

TheraLight is focused on developing non-invasive therapeutically validated photobiomodulation, or red light therapy, technology that is used to treat patients with a wide variety of conditions. We are committed to providing the highest quality of manufacturing to ensure the best therapeutic outcomes, innovative technology to keep pace with a rapidly maturing industry, and turn-key marketing solutions to maximize clinical success. We have grown to become a world-wide leader with over 1,000 customers worldwide and adding more each day.

Town & Country Compounding Pharmacy

Booth #245

535 East Crescent Avenue Ramsey, NJ 07446

USA

Ph: (201) 447-2020

Email: pharmacist@tccompound.com

TCCompound.com

Town & Country Compounding, ranked among the top 1% of compounding pharmacies nationwide, sets the standard for safety, precision, and innovation. Our NABP and PCAB/ACHC-accredited pharmacy specializes in crafting customized medications when standard options fall short—adjusting dosages, enhancing flavors, or creating unique formulations tailored to individual needs. Our mission is to foster better health outcomes for our patients. We’re committed to helping people live happier, healthier lives through the art and science of compounding. We compound quality!

TrueBinding - Metaverse One

Booth #401 4701 Patrick Henry Drive Building #21 Santa Clara, CA 95054 USA

Ph: (650) 847-1117

Email: eap@truebinding.com www.truebinding.com

TrueBinding Inc. is a clinical stage biotherapeutic company creating new and exciting molecules for applications in neurodegenerative and metabolic diseases, stroke, oncology and other areas with great unmet medical need.

UltraLux Health, LLC

Booth #842

782 S Auto Mall Drive Ste C American Fork, UT 84043 USA

Ph: (855) 479-4149

Email: hello@ultraluxhealth.com ultraluxhealth.com

Ultralux is the future of personalized wellness, providing modern solutions for modern health problems. UltraluxONE, our exclusive membership, offers genetics-based health insights, personalized supplements, and wellness perks to optimize longevity, performance, and vitality. Our products blend science-backed innovations with cutting-edge technology, including red light therapy, infrared saunas, hydrogen water, and advanced filtration systems— ensuring your health is always one step ahead.

University Compounding Pharmacy

Booth #319

1875 3rd Avenue

San Diego, CA 92101

USA

Ph: (800) 985-8065 x5700

Email: info@ucprx.com

www.ucprx.com

UNIVERSITY COMPOUNDING PHARMACY (UCP) a nationally recognized leader in drug and device therapies. For 35 years our expert Pharmacists and experienced Physician Liaison team have been dedicated to support an unbiased product line, devising the management of BHRT conditions for your patients. We meet FDA & BOP prescription requirements and dispense in nearly 50 states.

COMPOUNDED: GLP-1, THYROIDS, ESTROGENS, PDE-5 INHIBITORS- BIOIDENTICAL HORMONES.

Vale Medical LLC

Booth #234

7231 S. 900 East Ste 200 Midvale, UT 84047

USA

Ph: (800) 699-9570

Email: carmine@valemedical.com

www.valemedical.com

Vale Medical, the leading Storz Medical shockwave therapy dealer in the United States, is dedicated to offering healthcare professionals cutting-edge technology, superior service, and comprehensive education to help them stay ahead of the competition.

Vertisis Custom Pharmacy

Booth #936

9343 E. Bahia Drive Ste 200 Scottsdale, AZ 85260

USA

Ph: (303) 476-3447

Email: matthewb@vertisis.com www.vertisis.com

Vertisis is one of the most unique sterile-injectable compounding pharmacies in the United States. Our focus is on going “above and beyond” traditional compounding pharmacies by raising the standards of 503A compounding pharmacies to include exceptional products, unique delivery, advanced education, and an amazing relationship with health care providers with a seamless delivery of care. We are Vertisis Custom Pharmacy, your custom compounding pharmacy for integrative and naturopathic IV therapies and compounds.

3521 Leonard Ct

Santa Clara, CA 95054

USA

Ph: (816) 868-5964

Email: support@vibrant-america.com www.vibrant-wellness.com

Vibrant Wellness is a leading science and technology company delivering life-transforming laboratory services using an integrated microarray platform that enables multiplex testing at an affordable cost.

Booth #937

800 Apollo Street

WA 98058

Ph: (888) 472-7771

Email: customerservice@vita-stream.com vita-stream.com

Our company was founded over a decade ago with a goal of giving you the highest quality supplements and health products to help you on your path towards vibrant health, beauty, and happiness. At times, the journey toward your goal can be challenging. You may encounter obstacles, setbacks, and moments of doubt. But keep in mind that any action you take to improve your health and well being is a victory.

El Segundo, CA 90245 USA

Ph: (310) 994-1757

Email: SALES@VITAHUSTLE.COM www.vitahustle.com

VitaHustle ONE is a revolutionary nutrition shake designed with patients’ holistic health in mind. It combines the power of whole food fruits, vegetables, superfoods, probiotics, essential vitamins, and adaptogens into one all-encompassing formula. Packed with clean, clinically-supported ingredients, VitaHustle ONE offers a complete daily solution to support gut health, energy, and overall vitality. ONE small step—integrating VitaHustle into daily life—can empower patients to take control of their health, simplify their nutrition, and improve their quality of life.

Vibrant Wellness

VitaHustle Inc.

#631

200 2nd Avenue S

Ph: (952) 500-2156

Email: info@vitlrx.com

www.vitlrx.com

VITL is an innovative platform that revolutionizes e-prescribing by connecting clinics to a growing network of compounding pharmacies nationwide, and makes the ordering process beautifully simple. Access thousands of products from one portal, and send orders in a matter of seconds. Utilize VITL+ to collect and automate patient payments and eliminate medication overhead.

VO2 Master Health Sensors

Ph: (778) 475-5755

Email: info@vo2master.com

vo2master.com

VO2 Master empowers wellness and longevity professionals with portable metabolic testing technology that delivers precise insights into oxygen consumption, metabolic efficiency, and ventilatory thresholds. ACCURATE | RELIABLE | PORTABLE

Trusted by professionals, our wireless, lab-free solution enables on-site testing to optimize health programs, enhance client fitness, and monitor progress. Ideal for fitness centers, wellness clinics, and health coaches, VO2 Master provides the tools to personalize strategies for improved energy, vitality, and long-term well-being. VO2 MAX | RESTING METABOLIC RATE

VSL#3 / Actial Nutrition, Inc.

Booth #1114

400 W. South Boulder Road Ste 2500 Lafayette, CO

Ph: (732) 551-0787

Email: s.androcy@vsl3usa.com www.vsl3.com

VSL#3 is a medical food probiotic for the dietary management of IBS, UC, pouchitis and other serious gut issues. It is the #1 gastroenterologistrecommended multi-strain brand in the US. It stands apart with its clinical research, guaranteed high-potency, and its diverse formulation. We are also happy to announce VSL4GUT a shelf-stable dietary supplement featuring the same 8 probiotic strains in VSL#3.. Both products are available at online at www.vsl3.com, on amazon.com at select retail pharmacies, and on the Fullscript platforms.

We Care Pharmacy

Booth #926

516 Fletcher Drive

Warrenton, VA 20186 USA

Ph: (540) 809-9901

Email: info@wecarepjarm.com wecarepharm.com

WeCare Pharmacy is a full-service compounding pharmacy specializing in IV therapy, BHRT, weightloss, men and woman health, other integrative and anti-aging therapies. Our goal is to come alongside your practice and provide you with creative products that help make you effective clinicians, innovative business owners and valued clinicians to your patients.

1331 W. Powell Way Lehi, UT 84043 USA

Ph: (801) 898-8050

Email: parker.breinholt@getweave.com www.getweave.com

Weave is the leading all-in-one communication and engagement platform for medical practices. From the first time a new patient calls your office to the final invoice and every touchpoint in between, Weave connects the entire patient journey. Let our software solutions help you elevate every experience for your staff and patients.

Wellness Pharmacy

3401 Independence Drive Ste 231 Birmingham, AL 35209 USA

Ph: (800) 227-2627

Email: info@wellnesspharmacy.com www.wellnesspharmacy.com

With over 60 years of compounding experience, Wellness Pharmacy is considered the industry leader in quality and customer service. Our specialties include chelation, bioidentical hormones, autism support, and preservative-free injectables. Wellness Pharmacy is also the only pharmacy to successfully patent the preparation of injectable glutathione. PCAB-accredited.

Wells Pharmacy Network

Booth

#1112

3420 Fairlane Farms Road Ste 300 Wellington, FL 33414

USA

Ph: (800) 622-4510

Email: info@wellsrx.com

www.wellsrx.com

Wells Pharmacy Network is a privately held, nationwide, compounding pharmacy specializing in solutions for wellness and anti-aging medicine including: Bio-Identical Hormone Replacement Therapy, Peptide & Regenerative Therapies, Weight Management, Sexual Wellness, Aesthetic Dermatology and Thyroid & Adrenal Health. This includes operating a 20,000SF 503A pharmacy and a 21,000SF FDA Registered 503B Outsourcing Facility that produces bulk medication. Our mission is to elevate compounding industry standards through a unique combination of superior science and service.

907

141 NW 20th Street Ste G1

Boca Raton, FL 33431

USA

Ph: (561) 221-1000

Email: A4M@Regenomedix.com

www.RegenOMedix.com

RegenOMedix™, a division of Zizion Group®, is an FDA-registered medical distributor specializing in natural and integrative therapies for Hair Regeneration, Aesthetics, Orthopedics, Sexual Wellness, and Wound Healing. We empower healthcare professionals with advanced products, targeted training, and innovative marketing to enhance patient outcomes and expand their practices. Through a collaborative partnership model, we provide tailored solutions, expert guidance, and ongoing support, ensuring long-term success and growth.

Your Medical Liaison

Booth #946

980 N Federal Hwy #110 Boca Raton, FL 33432

USA

Ph: (866) 967-0122

Email: info@ymlteam.com yourmedicalliaison.com

Your Medical Liaison – Full Service Marketing for Functional & Integrative Medical Practices. Since 2012, we’ve been the trusted partner for MD/DOs, offering full service solutions designed to attract ideal patients, grow your practice, and maximize ROI—all without adding to your workload. Let us take care of the complexities of medical marketing, so you can reclaim valuable time for yourself and your loved ones. SIGN UP FOR YOUR FREE MEDICAL MARKETING AUDIT TODAY at www.YMLTeam.com

ZEO ScientifiX

#1028

3300 S. University Drive Ste 246 Ft. Lauderdale, FL 33328

USA

Ph: (888) 963-7881

Email: info@zeoscientifix.com zeoscientifix.com

Based in South Florida, ZEO ScientifiX is a publicly traded biotechnology company dedicated to advancing regenerative medicine. We focus on researching, developing, and manufacturing novel biologic therapeutics, envisioning a future where innovation leads to a healthier world. Our mission is to revolutionize regenerative medicine through cutting-edge nano-technologies and establish ourselves as a leading incubator for next-generation biologic treatments.

ZRT Laboratory

8605 SW Creekside Pl Beaverton, OR 97008

USA

Ph: (866) 600-1636

Email: info@zrtlab.com www.zrtlab.com

ZRT laboratory, a CLIA-certified commercial and research laboratory, is the recognized leader in innovative and meaningful hormone and wellness testing. ZRT has pioneered testing methods for hormones, neurotransmitters, heavy metals and more, offering health care professionals convenient testing options in different body fluids including saliva, dried blood spot, dried urine, and serum. ZRT provides comprehensive test results that allow providers to create personalized treatments for optimal outcomes, with the help of our knowledgeable clinical consultants.

Booth

Zizion Group Inc. Booth #

www.OxygenHealthSystems.com

EDUCATIONAL SCHEDULE 2025

Cognition 360 May 1-3

Hormone Dosing Therapy May 2-3

Masterclass

A4M SUMMER SCHOOL

Clinical Approaches to Sleep August 1-2 and Longevity

Women's Health Summit October 9-11

Empowering the Menopause Journey

OCTOBER BOSTON, MA