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Caffeine, Cetirizine, Nimesulide, Paracetamol & Phenylephrine Tablet (Benacof) Taj Pharma
symptomatic treatment of painful osteoarthritis and primary dysmenorrhoea.
1. COMPOSITION: Each tablet contains; Caffeine BP 25mg Cetirizine IP 5mg Nimesulide IP 100mg Paracetamol IP 325mg Phenylephrine IP 5mg 2. DOSAGE FORM: Tablet 3. DESCRIPTION: This product is a combination of Nimesulide, Paracetamol, Cetirizine, Phenylephrine and Caffeine. Caffeine is a stimulant which decreases sleepiness caused by Cetirizine. Cetirizine is an antiallergic which relieves allergy symptoms like runny nose, watery eyes and sneezing. Nimesulide is a non-steroidal antiinflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer) which also blocks the release of certain chemical messengers in the brain that cause pain and fever. Phenylephrine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. 4. PHARMACOLOGY: 4.1 Pharmacodynamics:
Paracetamol has analgesic and antipyretic properties. Paracetamol's effects are thought to be related to inhibition of prostaglandin synthesis.
Pharmacodynamics Properties of Nimesulide: Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic antipyretic properties. It selectively inhibits cyclooxygenase-2 (COX-2). It is indicated as second line treatment for acute pain,
Pharmacodynamics Properties of Paracetamol:
Pharmacodynamic Properties of Cetirizine HCL: Cetirizine is a third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Cetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, cetirizine has fewer side effects than most second-generation antihistamines. Pharmacodynamic Phenylephrine:
Properties
of
It is a sympathomimetic vasoconstrictor that has been used as a nasal decongestant. Phenylephrine constricts the blood vessels in the nasal mucous membranes and allows the air passages to open up. It is relatively selective alpha-adrenoceptor agonist. The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors. At therapeutic doses, it does not cause significant stimulation of the central nervous system.