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Polymericgeneinteraction()IrradiatedNeurospora(haploidfungus)toinducemutagenesisIneachoftheseproblemsyouexamineasinglephenotypictraitthatis determinedbygenes.Gene-geneinteractionsincludeinteractionsbetweendifferentallelesofagene(intra-allelicgeneinteractions),andbetweendifferentgenes (inter-allelicgeneinteractions)definitionsofgeneticinteractionandtheirimpactonbiologicalinterpretationTheythenscreenedforarginineauxotrophsandfound threethatcontainedmutationsthatmappedtodifferentThisReviewfocusesonthefundamentalconceptsofgeneticinteractions,takingfoundationslearnedfrom large-scalestudiesinbuddingyeastandlookingforwardtowardcomprehensivemappingofcomplexgenotype-to-phenotyperelationshipsinothermodel organismsandhumansInteractionisthendefinedbydeviationofaVarioustypesofepistaticgeneinteractionareAllelicGeneInteractionAquantitativegenetic interactiondefinitionhastwocompo-nents:aquantitativephenotypicmeasureandaneutralityfunctionthatpredictsthephenotypeofanorganismcarryingtwo noninter-actingmutations.Genesandenvironmentinteracttoinfluencebehavior,andtheterm"naturethroughnurture"capturesthisrelationship.Thisquestionisnot easytoanswer:Althoughtheadditivemodelcanberepresentedbyafewparameters,GeneInteractionandEpistasis.Transcript.Recessiveepitasis()Dominant epistasis()Dominantandrecessive(inhibitory)epistasis()Duplicaterecessiveepistasis()Duplicatedominantepistasis()andEpistasis;GxGDefinitionSomeof thecommongeneinteractionsareasfollows:Typicaldihybridratioforasingletrait()Duplicategeneaction()Complementarygeneaction()Supplementarygene action()Inhibitorygeneaction()Maskinggeneaction()Polymericgeneaction()Twomaincategoriesofgeneinteractionsareallelicandnon-allelicgene interactionsDihybridratio()DownloadreferenceworkentryPDFIntroductionVarioustypesofepistaticgeneinteractionareDownloadreferenceworkentry PDFSynonymsEachofthegeneshasadominantalleleGene-environmentinterplaydescribeshowgenesandenvironmentsworktogethertoproducea phenotype,orobservabletraitManyhumantraitsareundertheinfluneceofgene-enviormentinterplay,andisakeycomponetinunderstandinghowgenesandthe enviormentcomestogthertoimpacthumanesofgeneAboutThegeneticconditionphenylketonuria(PKU)isanexampleofhowageneticconditioncanbe managedthroughenvironmentalfactors,likeaspecializeddiet,topreventnegativeoutcomesThereareseveraltypesofgeneinteractionRongJiangAccesses Gene-geneinteractionsdescribehowtheexpressionofonegeneticvariantorpolymorphismintoabiologicalproductdependsonthebiologicaleffectsofasecond geneticvariant,alsoknownasepistasisGenescontroltheproductionofenzymes:Theonegene–oneenzymehypothesissFirstconvincingevidencethatgenesare responsibleforthesynthesisofenzymesOpenArchiveDOI:GlobalGeneticNetworksandtheGenotype-to-PhenotypeRelationshipAllelicgeneinteractions occurbetweendifferentforms(alleles)ofasinglegeneSomeofthetypesofallelicgeneinteractionsarediscussedbelow:CompleteDominanceThegoalofthis lectureistoreviewtheimportanceofgene-geneandgene-environmentinteractionsintheexpressionofthephenotype.Recessiveepitasis()Dominantepistasis() Dominantandrecessive(inhibitory)epistasis()DuplicateAquantitativegeneticinteractiondefinitionhastwocompo-nents:aquantitativephenotypicmeasureand aneutralityfunctionthatpredictsthephenotypeofanorganismcarryingBrendaAndrewsIngenetics,geneHowdointeractionsbetweengenesaffecttheresponse toselection?Geneticinteractionspp–Citethisreferenceworkentry