Top 10 Rising Startups in Chennai 2022 (Edition-2)

MAY 2022

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Top 10 Rising Startups In

2022 Top industries in Tamil Nadu Why startups are important for healthcare industry?

Economy of Tamil Nadu

Ascribe Healthcare Solutions Private Limited Dr. Jaisheela Padmanabhan Founder & CEO

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From the

EDITOR I

n today’s corporate atmosphere, modern organizations thrive and succeed for a variety of reasons. Some are recognized for their products, while others are known for their services, and yet others are known for less clearly defined characteristics like strong brand loyalty or captivating advertising campaigns.

However, if you look at the firms that genuinely stand out today as obvious leaders in their industries, you’ll see that they all have one thing in common: they all value innovation. Different startups from every corner of the nation are introducing practically visionary solutions to the market. Startup entrepreneurs maintain a different approach than the regular/traditional business model.

Every state in India has its own independent plans to increase the number of businesses in the state and encourage the younger generation to take active participation in the employment generation. Chennai is one of the most important port cities for business in India.

Located in the southern part of the nation, the city caters to multiple industries such as automobiles, information technology, electronics

manufacturing, textiles, etc. The traditional approach has been at the forefront of the city.

Chennai Port is the third oldest port in India, serving for more than 100 years in the nation’s maritime trade. From a trade perspective, Chennai has several MNC manufacturing units which produce goods for domestic as well as international markets. Having a reliable port is an added advantage to the trade. But there’s always a limit to such a business model. Startups have come up with an innovative approach to serving in the services industry.

Startups from Chennai have created an impact that is encouraging new startup ideas from this coastal city. It is not just on ground startup environment in Chennai, Space startups are even in the race to innovate & deliver small-scale rocket launchers with 3D printed rocket engine. A combination of experienced professionals and university professors guides the young ideas created out of the youth that are rising at large.

On the cover page of our edition of “Top 10 Rising Startups In Chennai 2022”, we have Dr. Jaisheela Padmanabhan, Founder & CEO of Ascribe Healthcare Solutions Private Limited. This startup was built by the founder from scratch. It covers healthcare billing and revenue cycle management.

SwiftNLift focuses on spot-lighting firms and startups that contribute to shaping lives better, intending to make our society a better place. It was a collective effort made by our team to bring you this edition. As the Chief Editor, I am grateful to you as our reader. I hope you enjoy reading this piece of our effort. We have other sections filled with trusted and resourceful knowledge and information to enhance your reading habits.

- Nilesh Sabe Nilesh Sabe Chief Editor

CONTENTS COVER STORY

Ascribe Healthcare Solutions Private Limited

ARTICLES 18

24

Top industries in Tamil Nadu

Why startups are important for healthcare industry?

30

34

Economy of Tamil Nadu

Rejuvenation of skin cell

Jana Analysis

Trance Home India Services Pvt Ltd

Dhvani Analytic Intelligence Pvt Ltd

Fusion VR

Hubino

Qruize Inc

Inaluz Pvt Ltd

Doozy Robotics

NIN Energy India Private Limited

Dr. Jaisheela Padmanabhan Founder & CEO

Top 10 Rising Startups In

2022

Ascribe Healthcare Solutions Private Limited

Ascribe Healthcare Solutions Private Limited The healthcare industry is upgrading its services to reach the last miles of the nation. India has recorded several startups that target the population that was left behind in this complete health benefits programme. Female entrepreneurs are leading some of these startups as they have witnessed problems at ground zero level.

circumstance and situation is not in favor or a plan not working as expected.

Tell us about your background.

I graduated with my degree in Physiotherapy; I also hold my credentials from the American association We had an opportunity to interview one such of professional coders. Recently, a few months ago, visionary, Entrepreneur & Founder of Ascribe I graduated in clinical cosmetology and aesthetics.

Along with my entrepreneur journey, I am pursuing Healthcare Solutions Jaisheela Padmanabhan. my clinical practice.

As a first-generation entrepreneur, what challenges were on the path while What made you enter the Healthcare technology industry? establishing Ascribe Healthcare?

Being first in the history of my family to dive into the sea of doing business on my own, I got very little advice & support from my closest and most trustworthy people. Unlike in jobs where the boss and seniors mentor, there was nobody to guide me for quite some time. As a first-generation entrepreneur, there were no bridges connecting me to the world of business. It is just the hunger for something more passionate and meaningful that was and is driving me towards entrepreneurship.

Building a strong team, retaining them and facing difficulties to pitch the ideas, values and vision to the team so that they are ready to work and stay with the company.

Robust cash flow is essential for survival. Strong financial planning and budgeting were needed because, by the time the client pays the invoices, I had to ensure that I pay everything on time from employee salary and bills. While waiting to get paid, make it difficult to run a business smoothly.

Staying self-motivated, cool-headed and strongly determined during the times when every

The healthcare industry has evolved immensely over the years, and much of that change has been driven by technology. The transformative power of technology could obviously not be missing from the healthcare sector. Even though it is a sector requiring highly skilled individuals with many years of studies, it is also a very demanding one in infrastructure and tools.

And the timing couldn’t be better, as spending or working in this sector is increasing at a rapid rate.

What are your Goals & Objectives?

My goals are to “GO-Global” and to build the business strong enough in revenue that it will continuously support the education of 10000 children. Not just a first-generation entrepreneur, I am also a firstgeneration female graduate. In my life, it’s only the education that gave me the success and truly transformed my life and I want to give the same hope and share the light with the less privileged. I strongly believe in working with transparency, integrity and generosity.

Tell us about your services.

Ascribe Healthcare Solutions, a revenue cycle management expert; we render superlative healthcare billing & coding solutions to clients through a reliable outsourcing model. Our services include: Doctor’s credentialing, EFT Enrolment, Eligibility and Benefits Verification, Medical Coding, Patient Demography, Charge Entry, Payment Posting, AR and Denial Management, Insurance appeal and its process, Medical records review, Medical records summarization, Daily Report preparation and management.

We are a core value-driven company with global clients in India, USA, Dubai, Oman, Qatar, Hong Kong and Australia.

Dr. Jaisheela Padmanabhan Founder & CEO

☐ Year of Founding: 2015 ☐ Founding Members: 01 ☐ Office Locations: Chennai - India, Delaware-USA, Dubai- UAE. ☐ Company Strength: 100 + ☐ Website: www.ascribehealthcare.com

Top 10 Rising Startups In

2022

Company Logo

TOP 10 RISING STAR Company Name

Company Management

Jana Analysis

Manoharan Duraisamy, CEO

Trance Home India Services Pvt Ltd

Kuttimanibaladurai Rajendran, Founder & CEO

Dhvani Analytic Intelligence Pvt Ltd

Prof. Krishnan Balasubramaniam

Fusion VR

Dr. C SS Bharathy, Founder

Hubino

Sathees K Ramasamy, CEO

Qruize Inc

Ezhil Arasan Babaraj, Principal Founder & CEO

Inaluz Pvt Ltd

The Team

Doozy Robotics

The Team

NIN Energy India Private Limited

The Team

RTUPS IN CHENNAI -2022 Company Description

Website

Digitizing the process of meidcal treatment & outcome data to transform Oncology care

https://www.janaanalysis.com/

Social assistance at every step to develop a society of change

https://trancehome.com/

Deep & Machine learning algorithms developed for Automatic Defect Recognition (ADR) using knowledge & data driven tools.

https://www.dhvani-analytic-intelligence.com/ home.html

Customer focused AR-VR & Industry 4.0 solutuions for making the digital transformation journey seamless

https://www.fusionvr.in/

Digital services for building a truly tech enabled future

https://www.hubino.com/

Empowering automation consulting & solutions for global business

https://www.qruize.com/

Solar energy solutions for green energy productuion

https://www.inaluz.com/

Integrating robotics technology in healthcare, hospitality, retail, warehouse, etc for dynamic future

https://doozyrobotics.com/

Helping improve energy efficiency for better energy consumption

https://ninenergy.com/

PRESS REALEASE PEAK (Program for Engineers’ Advanced Knowledge),– A Highly Interactive and Thought-provoking Session for The Students by SICCI Chennai, India, May 14, 2022 / SwiftNLift PR: The virtual event PEAK (Program for Engineers’ Advanced Knowledge), an Industry-Academia Series for students in the field of Engineering and Technology organised by The Southern India Chamber of Commerce and Industry, Chennai on Saturday, 14th May 2022, received an overwhelming response from college students across the country.

The participation of thousands of students from Top colleges like Sri Venkateswara College of Engineering, Chennai. Vellore Institute of Technology, Vellore. Symbiosis Institute of Technology, Pune. Francis Xavier Engineering College Tirunelveli. Rajalakshmi Engineering College, Chennai.

National Engineering College kovilpatti. Kalasalingam University, Krishnan Koil, CPAT TVS, Chennai made this virtual event a grand success.

The participants actively asked many thought-provoking questions about AI and data science to the two eminent panel speakers, Mr. Ramana Prasad, Chairman, AI World School, Governing Council member- Centre for Innovation (CFI) IIT Madras, International Catrobat Foundation, Gra University of Technology, Austria and Mr. Gopi Koteeswaran, Chair, SICCI EIS Committee & Founder, Dzruptiv AI. There were discussions on How to become an AI Expert, Career opportunities in AI, Limitations of AI, choice of organizations to work for, and how students can upskill themselves. Session Moderator, Mr. George Koshi, Chair, SICCI Employability Taskforce & Director - Learning and Development, Sify Technologies Limited.

Mr. Ramana Prasad, interacted with students about the need of continuous learning, upskilling, developing creative and innovative skills, and learning computer science skills. He also mentioned that his organisation is working on providing AI training to students in schools students should have a zeal for learning, and focus on the fundamentals.

Mr. Gopi explained how students should connect the theoretical concepts with real life. He also asked students to be super curious, focus on sharpening their mind, and participate in various global events and contests.

Mr. Ramana Prasad thanked The Southern India Chamber of Commerce and Industry (SICCI) for conducting such an interactive virtual event. He also mentioned that such sessions need to be conducted frequently to provide valuable insights to students from engineering and technology fields.

Regards, Mohammed Zabiullah Hamid Global Engagement - Brand Strategist Mobile: +91 90921 78692 Webpage: aiworldschool.com

About SwiftNLift PR Swiftnlift Press Release (www.swiftnlift.com) has a history of working with clients from a diverse range of industries including Image Consulting, Automotives, Fast Moving Consumer Goods (FMCG), Finance and Banking, Food, Retailing, Organizing Sports, Events, Governments and Associations, Healthcare, and Pharmaceutical and more.

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Top industries in Tamil Nadu Several industries are booming in Tamil Nadu. Tamil Nadu is ranked thirst industrial state in India followed

by Maharashtra and Gujarat. Textile, sugar, paper, leather, cement, electrical equipment, automobiles, information technology (IT), tourism and many more industries have covered the Tamil Nadu State.

New industrial policy in the state

While the State Government focuses on improving the State’s competitiveness in the new growth sectors, it is also committed to revitalizing traditional industrial sectors, with the stated goal of making Tamil Nadu a regional gateway to Asia and a top-ranking exporter of Tamil Nadu Industrial Development Corporation manufactured goods. The state’s policy has emphasized (TIDCO) encourages large and medium scale facilitating and incentivizing large mother industries industries in Tamil Nadu through new joint venture to locate in Tamil Nadu. The new industrial policy projects in the manufacturing sector. TIDCO has emphasizes the balanced development of traditional shifted more towards infrastructure projects with the and modern industries. liberalization of industrial licensing and controls. It Promotion of SEZs for footwear and leather boosts Special Industrial Areas (SIA) and Agricultural processing, agro-processing and export of agro Export zones (AEZ) through joint ventures. products, and establishment of co-generation 18

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centuries. The annual turnover of the industrial sector including tanneries, shoe factories, garment and leather goods-producing units is Rs.4,500 crores, of which Rs.2,750 crores is the income from export.

According to the Tamil Nadu New Industrial Policy 2003, the state has 70% of leather tanning capacity in India and 38% of leather footwear and components.

The exports from Tamil Nadu are valued at about Manufacturing and engineering industry US $ 762 million, which accounts for 42 % of Indian It is one of the vibrant sectors in Tamil Nadu. leather exports.

It contributes greatly to the industrial output.

It covers the manufacturing of machinery, transport parts, basic metal & alloy industries and Paper industry metal products.

Tamil Nadu is India’s second-largest paper producer, trailing only Andhra Pradesh. plants and ethanol units in sugar mills are some of the initiatives started in the new industrial policy in the traditional industrial sector. High priority is for the promotion of industries in high-tech areas like semiconductors, electronic hardware and nanotechnology.

Automobile industry

Paper mills can find in Pukkathurai in the Kancheepuram district, Bhavanisagar, Pallipalyam, Pugalur, Paramathi, Vellore, Coimbatore, Udumaliapettai, Thoppampatti, Nillakkottai, and Cheranmadevi.

The automobile industry contributes 8% of Tamil Nadu’s GDP. This industry accounts for approximately 21% of passenger cars and 33% of commercial vehicles produced in India. Chennai is the home of 30% of India’s automobiles and 35% of its automotive Food industry components. Because of its industrial dominance, Tamil Nadu’s food and beverage industry are thriving.

Chennai has earned the moniker “Detroit of Mango pulp is manufactured and exported. Instant Southern Asia.” food and cooking ingredients are manufactured and marketed both locally and internationally.

Snacks and biscuits are widely distributed. Tamil Leather industry Nadu’s long coastline provides opportunities for The growth of the leather industry is because of marine-based industries. the large tannery base established over the last two 20

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Sugar industry

Ltd. are two notable chemical industries in Tamil Nadu. Pfizer Pharmaceuticals and Dow Chemicals are two major chemical companies with research and development facilities in Chennai.

Tamil Nadu accounts for roughly 10% of total sugar production in India. The cooperative sector employs the vast majority of sugar units in the state.

Tamil Nadu currently has 42 sugar mills, with 16 in the cooperative sector, 3 in the public sector, and 23 in the private sector. Sugar mills are concentrated Electronics industry in the districts of Villupuram, Cuddalore, Electronics is an emerging industry in Tamil Nadu.

Vellore, Erode, Coimbatore, Thiruvannamalai, Many prominent global telecommunications like Nokia, Flextronics, Motorola, Sony-Ericsson, Thiruchirappalli, Thanjavur, and Madurai.

Foxconn, Samsung, Cisco, Moser Baer, and Dell have picked Chennai as their South Asian Cement industry manufacturing hub.

Tamil Nadu ranks fourth in cement production in the country. It accounts for 10% of total cement production in the country. Tamil Nadu Cements Textile industry Corporation Limited (TANCEM) is wholly It is the major industry in Tamil Nadu. It provides owned by the Government of Tamil Nadu and large-scale employment and prominent source of produces Ordinary Portland Cement (OPC) and foreign exchange.

Super Star Cement that exceeds Indian standards.

Sankari, Madukarai, Ariyalur, Dalmiapuram, Manamadurai, Thulukapatti, Allankulam, IT industry Sankarnagar, and Thazhaiyuthu are major cement Tamil Nadu has always been a welcoming state to industry centres. investors. Proactive government policies and the

state’s peaceful environment attract investors from all over the world. Tamil Nadu is the preferred Chemical industry destination for all multinational IT companies. Few The majority of Tamil Nadu’s chemical industries examples of IT companies in Tamil Nadu include have concentrated in and around Chennai Amazon, Aspire systems, Bhavan Cybertech, Consim, (Manali), Cuddalore, Panangudi (Nagapattinam), CSS Corp, Cognizant, HCL, Ford, Zoho and others and Thuthukudi.

- Varada Ukidave SPIC (Southern Petrochemical Industries Corporation Ltd.) and Manali Petrochemicals

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Why startups are important for healthcare industry?

The Healthcare industry is one of the fastest-growing industries not only in India but also all over the world.

It significantly contributes in terms of employment and revenue. Hospitals, medical devices, clinical trials, outsourcing, telemedicine, medical tourism, health insurance, and medical equipment are all part of the Indian healthcare industry.

challenges, including COVID; startups become a valid and vital part of industry conversations and movements.

Importance of startups Some key importances mentioned below:

of

startups

are

The industry is expanding at a rapid pace as a result of improved coverage, services, and increased spending ■ Startups find a solution rapidly Startups come with new ideas and innovative by both public and private players. Doctors are also solutions much faster than well-established firms. like scientists as they are continuously doing research The startups can specialize in an ultra-specific area and analysis to find new and better things. Healthcare which established firms may not do with dedicated innovations should not be taken for granted. time or other issues.

Startups are aims to implement new ideas. Startups are an integral part of healthcare innovations.

After all, the core of the startup is to rethink and adopt its disruptive nature to challenge norms and seek more efficient and higher-quality outcomes. It makes sense that, as the healthcare industry faces numerous 24

■ Need for more perspectives on healthcare solutions Unfortunately, bias is the reality in medical research.

To achieve an exact result, research should include diverse perspectives and data. Startups can research with diverse perspectives to implement their ideas.

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☐ Need of Startup

■ Innovation The main goal of the startups is innovation. They enter the market with unique ideas. They can find creative solutions to complex problems in the industry.

■ Support Startups based on technology support the healthcare industry. AI has great applications in healthcare. AI is a significant component in healthcare innovations.

The gap between the needs of care seekers and traditional healthcare services is increasing. And it becomes a major challenge for the healthcare industry. It is unaffordable for the healthcare sector.

On the other hand, these factors lead to the growth of the healthcare startups ecosystem and encourage them to innovate. Startups not only help the patients to get qualitative healthcare services but also create employment. According to Invest India, the sector will create 40 Mn jobs by 2030.

For example, AI aided in the global recovery from the COVID-19 pandemic, which lasted nearly two years. AI has been used in the healthcare industry List of best startups in India for a variety of purposes, including early detection of Some of the startups in the healthcare industry are COVID-19, patient assistance, and so on. listed here:

Challenges of healthcare India faces some challenges in the healthcare sector including limited access, investment and an increase in chronic disease burden. These challenges may be an opportunity for any startup.

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☐ Netmeds Netmeds is an online platform for pharmacy.

Netmeds has millions of active customers and deliveries over 19, 000 PIN codes in the country. It is also known as ‘India ki Pharmacy’.

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☐ ImpactGuru The vision of the startup is to make healthcare accessible to all and save more lives. It is a crowd funding platform for medical purpose. ☐ Docplexus This platform is for doctors. Doctors can create their communities on the platform and discuss problems all around the globe. Phanish Chandra is the founder of Docplexus. It has more than 2,75,000 doctor members. ☐ Mera Medicare MeraMedicare is a healthcare startup founded by Pankaj Gupta. MeraMedicare offers home delivery of medications in 2 to 12 hours and a 15% discount on almost all medications. It is a dependable and hasslefree method of ordering medications.

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☐ 3Hcare 3Hcare is a healthcare startup based in Delhi. It is a healthcare services marketplace on the internet.

3Hcare provides comprehensive information on healthcare services in India. Users can simply visit 3Hcare’s website to learn more about diagnostic centers and hospitals that meet their needs. The name “3Hcare” stands for “Help, Health, and Happiness,” and it represents the startup’s goal of assisting people in maintaining their health and happiness.

Final thought The healthcare industry is constantly evolving in terms of disease, treatment, and research. Startups contribute to the growth and development of the industry as a whole. Startups are important in all sectors of the healthcare industry.

- Varada Ukidave

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Economy of Tamil Nadu Tamil Nadu is India’s fourth-largest state located on the southern coast of India. It ranks first as a state in the total number of factories and industrial workers. Between the years 2015-16 and 2020-21, Gross State Domestic Product (GSDP) grew at a Compound Annual Growth Rate (CAGR) of 10.56% to reach Rs 19.43 trillion (USD 265.49 billion). In 2020-21, the contribution of the tertiary sector to the State’s Gross State Value Added (GSVA) at current prices was 54.26% followed by the secondary sector at 32.39%.

Total commodities exports from the state stood at US$ 30.02 billion in the financial year 2020. In the financial year 2021, exports stood at US$ 26.16 billion.

The economic structure of Tamil Nadu has transformed from the Primary sector in the 1960s to tertiary activities in the 2000s.

The main contributors to the economy of Tamil Nadu are agriculture, fishing and forestry, resources and power, manufacturing, services and transportation.

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Agriculture, fishing and forestry Since 1960, the state has been self-sufficient in food grain production. The lad crops for domestic consumption are rice, millet and other cereals, peanuts and pulses, sugarcane, cotton, cashews and chilies. Many farmers also grow livestock, main cows for the dairy industry, poultry, goat and sheep.

Tamil Nadu is also the top fish producer in India. The major yield is from marine fishing. State also has an active forestry sector with pulpwood, babul, firewood, bamboo and teak as primary products and Rubber is also an important crop.

Resources and power Minerals like limestone, bauxite, gypsum, lignite (brown coal), magnesite, and iron ore are major minerals mined in Tamil Nadu. Neyveli, an opencast lignite mine is one of the largest mines in India. Tamil Nadu, as an MAY 2022

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food processing, and the production of pharmaceuticals, chemicals, and electronic parts and equipment are also important manufacturing activities. Coimbatore is referred to as the “Manchester of South India” due to its extensive textile industry, and it is also known as “the Tamil Nadu has the distinction of being India’s Pump City” because it supplies half of India’s motor and renewable energy leader, having adopted clean energy pump requirements. sources and established wind farms as early as 1995. It Handicrafts are also abundant in Tamil Nadu, now generates more wind power than Denmark and particularly brass, bronze, and copperware, leatherwork, the Netherlands combined. Its products use to fuel a hand-loomed silk, kalamkari (hand-painted fabric thermal-power plant which provides much of the state’s using natural dyes), and articles made of carved wood, electricity. The majorly of the energy requirement of palm leaf, and cane.

Tamil Nadu is generated by thermal power plants. Also, Tuticorin is known as the ‘Gateway of Tamil Nadu’. It is hydroelectric plants, particularly along the Kaveri River a larger producer of chemicals. It all produces 70% of and its tributaries, provide an important secondary total salt production in the state and 30% in the country. source of energy. The state is also a leader in wind energy generation. industrialized and urbanized state, ranks among the top three states in terms of electricity generation. As of September 2018, Tamil Nadu’s total installed capacity was around 30,200 MW, with 11,500 MW coming from solar and wind energy.

Services

The service sector is developing since the 20th century.

And by 21 century it is the largest contributor to the Tamil Nadu is one of India’s most industrialized states, state’s economy. Expansion in the IT industry has with the manufacturing sector accounting for more than been the priority of the economic development policy. one-third of the state’s GDP. Heavy vehicle production, The state also encourages tourism, infrastructure such as automobiles, agricultural equipment, military development project, restaurants, and cultural & vehicles, and railway cars, is one of the state’s major recreational attractions. industries; the railway coach factory at Perambur (near Chennai) is one of Asia’s largest. One of the biggest The state government is stimulating industrial parks electrical equipment public sector companies BHEL has such as Rubber Park, Apparel Parks, Floriculture its manufacturing unit in Tiruchirappalli and Ranipet. Park, TIDEL Park for IT/ITS, TICEL BioPark for The Tamil Nadu state government owns the Tamil Nadu Biotechnology, Siruseri IT Park, Elcot SEZ and Agro Newsprint and Papers (TNPL), the world’s largest Export Zones among others. Two major seaports bagasse-based paper mills in Karus, Tamil are there in Tamil Nadu. The international airport at Nadu. Chennai has an oil refinery Meenambakkam is one of the largest airports in India.

- Varada Ukidave and a petrochemical plant.

Manufacturing

Textile

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milling,

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Rejuvenation of skin cell The Babraham Institute has devised a mechanism to Stem cells ‘time jump’ human skin cells by 30 years, effectively These are undifferentiated cells that can turn turning back the clock for cells without affecting their into specific cells, as the body needs them. Adult specialized function. body tissues and embryos are the two sources of Researchers in the Institute’s Epigenetic research stem cells.

(Epigenetic is the study of how your behaviors and Stem cells present in the following tissues: environment can cause changes that affect the way your genes work.) department have been able to partially ■ the brain repair the function of aged cells while also revitalizing ■ bone marrow molecular measurements of biological age.

■ blood and blood vessels

Regenerative medicine Our cell’s ability to function reduces as we age, and the genome collects signs of aging. Regenerative biology seeks to repair or replace cells, including those that have died. Our ability to generate ‘induced’ stem cells is one of the most essential tools in regenerative biology. The procedure consists of numerous phases, each of which removes some of the markers that differentiate cells. In theory, these stem cells can become any cell type, but scientists have yet to successfully reproduce the conditions that allow stem cells to re-differentiate into all cell kinds.

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■ skeletal muscles ■ skin ■ the liver Stem cells are important for the following reasons: ■ It increases understanding of how diseases occur.

■ It generates healthy cells to replace cells affected by disease (regenerative medicine).

■ It is used to test new drugs for safety and effectiveness.

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History

Current and future scenario

The approach dates back to the 1990s when researchers at the Roslin Institute, Edinburgh established a way of converting an adult mammary gland cell from a sheep into an embryo. It resulted in the development of Dolly, a cloned sheep. The goal of the Roslin team was not to generate sheep clones or even human clones but to use the process to create so-called human embryonic stem cells. Scientists thought that by growing them into specific tissues like muscle, cartilage, and nerve cells, they would be able to replace worn-out bodily parts. Prof Shinya Yamanaka simplified the Dolly procedure in 2006.

The prospective applications of this technology rely on the cells not just appearing younger, but also functioning as young cells. Fibroblasts produce collagen, a substance present in bones, skin, tendons, and ligaments that aids in tissue structure and wound healing. When compared to control cells that did not go through the reprogramming process, the rejuvenated fibroblasts produced more collagen proteins. Fibroblasts also migrate to places that require healing. The partially regenerated cells were examined by making an artificial cut in a layer of cells in a dish. They discovered that treated fibroblasts moved faster into the gap than older cells. This is a positive hint that one day, this study could be utilized to make cells that repair wounds more effectively.

Development Shinya Yamanaka was the first scientist in 2007 to convert normal cells with a specified function into stem cells with the ability to develop into any cell type. The entire process of stem cell reprogramming takes around 50 days and involves four critical molecules known as the Yamanaka factors. The new technique, known as maturation phase transient reprogramming,’ exposes cells to Yamanaka factors for only 13 days. Age-related alterations have been erased at this point, and the cells have momentarily lost their individuality.

The partially reprogrammed cells were allowed to develop normally for a while to see if their specific skin cell function was restored. A genome study revealed that the cells had regained skin cell markers (fibroblasts).

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This research may also open other therapeutic possibilities in future. The researcher have observed that it’s also affects the other linked gene eg. APBA2 gene associates with Alzheimer’s disease and MAF gene associates with development of cataract both showed changes in youthful level of transcription.

Scientist highlighted that the research findings represent a significant advancement in understanding of cell reprogramming. Scientist demonstrated that cells can be rejuvenated without losing function, and that rejuvenation attempts to restore some function to old cells. The fact that a reversal of ageing indicators observed in genes associated with diseases is especially encouraging for the future of this research.

Endnote The implications of this work are really exciting. Scientists may eventually be able to find rejuvenating genes that do not require reprogramming and selectively target them to minimize the consequences of ageing. This method has the potential to yield crucial discoveries that could pave the way for a fantastic therapeutic horizon.

- Varada Ukidave

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