The Prescription Monitoring Program (PMP) toolkit was developed to assist tribal public health programs and tribal entities navigate their states’ PMP. The PMP can be a powerful tool to help strengthen communities, provide medical care, reduce the diversion of prescription drugs, and guide the longevity of prevention programs. Included in this document, you will find an overview of the PMP in Kansas, Oklahoma and Texas, learn in detail how pharmacies/tribal health systems play a role, and the positive impact it has on tribal prevention programs.