Introduction of Sterilization and D-value learnpharmacy.sgrealinfo.com/2020/05/Introduction-of-sterilization.html
Sterilization definition Sterilization and sterility testing, principle, validation of various sterilization processes, methods, industrial sterilizer, air handling unit and sterility testing of different types dosage form.
Sterilization Introduction Sterilization can be defined as that effectively kills or eliminates those transmissible agents (such as fungi, spores, yeast, molds, viruses, bacteria, bacterial, etc) from a surface, equipment, foods, medications, or biological culture medium. In practice sterility is achieved by exposure of the object to be sterilized to chemical or physical agents for a specified time. Various agents used as sterilants are: elevated temperature, ionizing radiation, chemical liquids or gases, etc. The success of the process depends upon which type of the method adopted for sterilization. The terms sterile, sterilize or sterilization refer to the complete absence or destruction of all micro-organisms and this should not be used as a relative term. It is an absolute one. An object is strictly sterile or nonsterile, there may be no semi sterile or almost sterile product. Pharmaceutical Importance of Sterilization • Moist heat sterilization is the most effectively biocidal agent. In the pharmaceutical industry, it is used for: Surgical dressings, Surgical and diagnostic equipment, Closures, Aqueous injections, Containers, Ophthalmic preparations and etc. • Dry heat sterilization can only be used for moisture-sensitive, thermostable, or moisture impermeable pharmaceutical and medicinal. These include products like; in non1/3