Alcohol, Tobacco, Marijuana: Editorial: the second end of Prohibition; winemaking with a medical bent; treating alcohol use disorders; new frontiers of tobacco danger; quitting smoking for good; practicing cannabinoid medicine. Departments: Eliminating hepatitis C; untangling genetically engineered food; five tenets for medical volunteering; mystery case: a patient with subacute progressive ataxia; book review of "Patient M"; mental illness during pregnancy.