Curriculum Vitae Javed Mahmood, PhD. Assistant Professor, Division of Translational Radiation Sciences, Dept. of Radiation Oncology, School of Medicine, University of Maryland Baltimore, USA. Contact Information Business Address: Business Phone Number: Cell: Email: Foreign Languages:
+1-410-706-5133 +1-443-546-5477 jmahmood@som.umaryland.edu English, Bengali, Hindi and Japanese
Education 1994 2001
Bachelor of Dental Surgery (B.D.S), Dhaka University, Bangladesh. Ph.D., Biochemistry, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan. Thesis advisor: Prof. Yoshinori Kuboki.
Post Graduate Education and Training 2007 - 2010
Post-Doctoral Research Fellowship in Applied Molecular Oncology/Radiation Oncology, Supervisor: Prof. Richard P Hill, Radiation Medicine Program, Princess Margaret Cancer Hospital, UHN, Toronto University, Canada. Ontario Cancer Institute of Princess Margaret Cancer Hospital is one of the largest cancer research/treatment centers in the world. I did my post-doctoral research works under Prof. Richard Hill, a world famous radiation biologist and worked as a team member of the Center for Medical Countermeasures against Radiation (CMCR) and worked in radiation-induced tissue damage funded by National Institute for Allergy and Infectious diseases (NIAID), USA.
Accomplishments: I published several high impact papers from Toronto University, Canada in accordance with Prof. Meetha Medhora of Milwaukee Medical College, Wisconsin, USA and Dr. Susan Doctorow, Associate Professor of the Faculty of Medicine, Boston University, USA. I developed new and effective mitigators against radiation induced lung damage (so far there is only one FDA approved mitigator is in the market).
Certifications 2013 2009-2010
Clinical Research Associate (CRA) Diploma, Kriger Institute, Canada Foundation & Leadership in Project Management, Toronto University, Canada
Employment History Academic Appointments 2001-2003
Assistant Professor (Medical Biochemistry), Bangladesh Medical College, Dhaka, Bangladesh.
Duties: 1. Lecturing undergraduate medical/dental students (60-70 students in class). 2. Curriculum development for undergraduate and post graduate courses. 3. Overseeing students research projects. Accomplishments: Successfully taught undergraduate students and took part in their professional exams as internal examiner (question setting, test result publishing, etc).
2003- 2006
Lecturer, Department of Cellular Physiology, Faculty of Medicine, Niigata University, Japan.
Duties: 1. Lecturing the undergraduate and graduate (30-40 students in class) students. 2. Supervised research of the Masters students (2). 3. Performed pharmaceutical (Novartis Pharma, Japan) & Japan Government funded research project on local delivery of angiotensin receptor blocker (ARB) to the damaged kidney to ameliorate glomerulonephritis in rats.
Accomplishments: 1. Published two high impact research articles. 2. Received Japanese Governmental and pharmaceutical company Research Grants. 3. Developed a unique drug delivery system locally, directly to kidney to lower the local blood pressure irrespective of systemic blood pressure. 3. Technically supported Novartis Pharma, Japan for their further research, developing a new concept of drug application in kidney diseases.
2011-2012
Visiting Associate Professor (Medical Biochemistry & Molecular Biology), Faculty of Dentistry and Pharmacy, UiTM University, Malaysia.
Duties: 1. Teaching undergraduate medical biochemistry/ molecular biology & oral biology courses (60-70 students in class and practical classes). 2. Supervised 1 Master’s and 2 PhD students of Faculty of Pharmacy and Dentistry, UiTM. 3. Curriculum development for undergraduate and post graduate courses including Problem Based & student centered learning program (PBL). Accomplishments: Established cancer research collaboration with Toronto University, Canada and Boston University, USA (still collaborating) on discovering new molecules against cancer by testing suitable candidates for novel tumor radio sensitizers derived from endogenous plants of tropical forests of Malaysia.
2012-2014 Research Associate & Project Lead, STTARR Innovation Centre, Radiation Medicine Program Princess Margaret Cancer Hospital (PMH), Toronto, Canada. Duties: 1. Leading the project for detecting cancer hypoxia and tumor microenvironment by image guided radiation therapy using PET FAZA scan, MRI, DCE CT, etc & testing of novel anticancer molecules/radio sensitizers developed by different pharmaceutical and biotechnology companies and University of Waterloo, Canada and supervising masters, PhD and undergraduate students. Focus: Tumor hypoxia, microenvironment and tumor interstitial fluid pressure are affecting severely the fate/prognosis of the patients with malignant tumors and their effective therapy. STTARR is a Centre of innovation and research excellence of Toronto University; leading this project to develop new drug against cancer and novel image guided targeted radiotherapy to eliminate chemotherapeutics or reducing the side effects of chemotherapy. Accomplishments: Working under Dr. David Jaffray, Director of STTARR Innovation Centre at the Princess Margaret Hospital. Dr. Jaffray is one of the most influential investigators in cancer imaging in North America.
As a Project Lead, I am successfully leading the collaborative project with the University of Waterloo and discovered a new pathway (using a new molecule) to induce tumor cell DNA damage, improve tumor microenvironment, tumor regression by increasing radio sensitization of the tumors to radiation therapy. This ground breaking work is currently in its final stage and sending soon to high impact cancer journal.
Local and National Service
2012-Present Reviewer of Radiation Research Journal, USA. Oral Oncology Journal, USA, and Archives of Oral Biology, USA.
Teaching Service Undergraduate Student Teaching 2003- 2006
Applied Research Training Program (summer students), Department of Cellular Physiology, Faculty of Medicine, Niigata University, Japan.
2011-2012
Undergraduate Course lecture (Biochemistry) and taking examinations, Faculty of Dentistry & Pharmacy, UiTM University, Malaysia.
2012-present Summer Student Program, STTARR Innovation Centre, Princess Margaret Cancer Hospital (PMH), Toronto University, Canada.
Post-Graduate Teaching 2003- 2006
Masters and PhD student’s research overseeing program, Department of Cellular Physiology, Faculty of Medicine, Niigata University, Japan.
2011-2012
Masters and PhD student’s research overseeing, Faculty of Dentistry & Pharmacy, UiTM University, Malaysia.
2012-present PhD student’s research overseeing, STTARR Innovation Centre, Princess Margaret Cancer Hospital (PMH), Toronto, Canada. Grant Support Completed Grants: 2004-2006
(PI, 100%) “Study to investigate the role Angiotensin Converting Enzymes (ACE) in experimental glomerulonephritis of rats” Ministry of Science & Technology,
Government of Japan. Total Direct Costs: $ 100, 000
2004-2006
(PI, 50% Dr. Javed Mahmood, rest 50% PI Prof. Takashi Oite) “Study to investigate the role of Angiotensin Receptor Blocker (Valsartan) in experimental glomerulonephritis of rats” Novartis Pharmaceuticals, Japan. Total Direct Costs: $ 80, 000
Publications
Peer-reviewed journal articles 1. Mahmood J, Jelveh S, Zaidi A, Susan D, Medhora M and Hill RP. Targeting the reninangiotensin system combined with an antioxidant is highly effective in mitigating radiationinduced lung damage. International Journal of Radiation Oncology, Biology, Physics (Volume 89, Issue 4, 15 July 2014, Pages 722–728). 2. Jelveh S, Kaspler P, Bhogal N, Mahmood J, Lindsay PE, Okunieff P, Doctrow SR, Bristow RG, Hill RP. Investigations of antioxidant-mediated protection and mitigation of radiationinduced DNA damage and lipid peroxidation in murine skin. Int J Radiat Biol. 2013 Apr 23. 3. Mahmood J, Jelveh S, Zaidi A, Susan D and Hill RP. Mitigation of Radiation-Induced Lung Injury with EUK-207 and Genistein: Effects in adolescent rats. Radiation Research. 2013 Feb;179(2):125-34. 4. Zaidi A, Jelveh S, Mahmood J and Hill RP. Effects of Lipopolysaccharide on the response of C57BL/6J mice to whole thorax irradiation. Radiother Oncol. 2012 Dec;105(3):341-9. 5. Mahmood J, Jelveh S, Zaidi A, Hill RP. Mitigation of lung injury following accidental exposure to radiation. Radiation Research 2011 Dec; 176(6):770-80. 2011 Oct 20. 6. Hill RP, Zaidi A, Mahmood J, Jelveh S. Investigations into the role of inflammation in normal tissue response in radiation. Radiotherapy and Oncology, 2011 Oct; 101(1):73-9. Epub 2011 Jul 2. 7. Mahmood J and Richard Hill. Mitigation of radiation-induced lung injury by Genistein and EUK-207. International Journal of Radiation Biology, August 87 (8): 889-901, 2011. 8. Rosenthal RA, Fish B, Hill RP, Mahmood J, Moulder J.E., and Doctrow S.R. Salen Mn complexes mitigate radiation injury in normal tissues (SOD Enzymes and Their Mimics in Cancer: Pro- Vs Anti-Oxidant Mode of Action). Anti-Cancer Agents in Medicinal Chemistry, 2011 May 1; 11(4):359-72.
9. Calveley VL, Jelveh S, Langan A, Mahmood J, Yeung IW, Van Dyk J, Hill RP. Genistein can mitigate the effect of radiation on rat lung tissue. Radiation Research. 2010 May;173(5):60211. 10. Mahmood J, Fahima Khan, Shinnichi Okada, Naoki Kumagai, Tetsuo Morioka, Takahi Oite.Local delivery of angiotensin receptor blocker into the kidney ameliorates progression of experimental glomerulonephritis. Kidney International. 2006 Nov; 70(9):1591-8. 11. Khan F, Yamakami K, Mahmood J, Li B, Kikuchi T, Kumagai N, Morioka T, Yoshizawa N, Oite T. Alterations of cell adhesion molecules in human glomerular endothelial cells in response to nephritis-associated plasminogen receptor. Nephron Experimental Nephrology. 2007; 105(2):e53-64, 2006. 12. Mahmood J, Takita H, Ojima Y, Kobayashi M, Kohgo T, Kuboki Y. Geometric effect of matrix upon cell differentiation: BMP-induced osteogenesis using a new bioglass with a feasible structure. Journal of Biochemistry. 2001 Jan; 129(1):163-71. 13. Vehof JW, Mahmood J, Takita H, van't Hof MA, Kuboki Y, Spauwen PH, Jansen JA. Ectopic bone formation in titanium mesh loaded with bone morphogenetic protein and coated with calcium phosphate. Plastic and Reconstructive Surgery. 2001 Aug; 108(2):434-43. 14. Kuboki Y, Jin Q, Kikuchi M, Mahmood J, Takita H. Geometry of artificial ECM: sizes of pores controlling phenotype expression in BMP-induced osteogenesis and chondrogenesis. Connective Tissue Research. 2002; 43(2-3):529-34. Awards: 1. Sangi Biotech Company Scholarship (1996-1998), Tokyo, Japan. 2. Rotary International Scholarship (1998-2001), Tokyo, Japan. Major Invited Speeches National & International 1. Forsyth Institute, Harvard Medical School, Harvard University, USA, October, 2005. 2. Novartis Pharmaceuticals, Niigata, Japan, June, 2006. 3. An Exclusive interview with Voice of America (VOA) June, 2009. 4. Student Career Workshop, Faculty of Medicine, Toronto University, 2012-2013.