Curriculum Vitae Young Kwok, M.D. Associate Professor Department of Radiation Oncology University of Maryland School of Medicine Date: April 3, 2014 Contact Information Young Kwok, MD Dept of Radiation Oncology University of Maryland School of Medicine 22 South Greene St. Baltimore, MD 21201 USA Email: ykwok@umm.edu Office: (410) 328-9134 Fax: (410) 328-5279 Education 1995 B.A. 1999
M.D.
Psychology, Johns Hopkins University, Baltimore, MD Departmental and General Honors Albert Einstein College of Medicine, Bronx, NY
Post Graduate Education and Training 2000 Internship Internal Medicine, Beth Israel Medical Center, New York, NY 2004 Residency Radiation Oncology, University of Maryland Medical Center, Baltimore, MD Certifications 2006
American Board of Radiology
Medical Licensures 2004 2004
Maryland State License, active Michigan State License, inactive
Employment History Academic Appointment 2004-2011 Assistant Professor, Department of Radiation Oncology, UMSOM 2011-present Associate Professor, Department of Radiation Oncology, UMSOM Clinical Privileges 2004-Present 2004-Present 2004-2010 2004-2010 2004-Present 2008-Present
University of Maryland Medical Center, Baltimore, MD Baltimore VA Medical Center, Baltimore, MD Maryland General Hospital, Baltimore, MD Montgomery General Hospital, Olney, MD Howard County General Hospital, Columbia, MD Baltimore-Washington Medical Center, Glen Burnie, MD
Young Kwok, M.D.
Professional Memberships 2000-2004 American College of Radiation Oncology 2000-2004 American College of Radiology 2000-Present American Society for Therapeutic Radiology and Oncology 2003-Present American Brachytherapy Society 2004-Present American Society of Clinical Oncology 2004-Present Radiation Therapy Oncology Group 2004-2011 Cancer and Leukemia Group B (CALGB) 2009-Present Children’s Oncology Group 2011-Present Alliance for Clinical Trials in Oncology (merged group of CALGB, NCCTG, ACOSOG) Honors and Awards Undergraduate 1991-1995 Full Academic Scholarship 1991-1995 Academic Dean’s List 1995 General and Departmental Honors Medical School 1998 Travel Grant: American Society of Hematology, Miami Beach, FL Residency 2002 2003 2003-2004
Roentgen Resident/Fellow Research Award: Radiologic Society of North America, Chicago, IL Travel Grant: Radiation Therapy Oncology Group Meeting, New Orleans, LA Chief Resident
Assistant Professor 2006 Teacher of the Year: Association of Residents in Radiation Oncology. 2008 Clinical Scholars Award: Cancer and Leukemia Group B, Chicago, IL Associate Professor 2012 Outstanding Reviewer of 2012, International Journal of Radiation Oncology, Biology, Physics Clinical Activities Clinical Expertise Genito-urinary malignancies Central nervous system malignancies Pediatric malignancies Lymphomas and leukemias Technical Expertise Intensity-Modulated Radiation Therapy (IMRT) Image-Guided Radiation Therapy (IGRT) Stereotactic Radiosurgery (SRS), Gamma-knife, Trilogy, Truebeam Fractionated Stereotactic Radiation Therapy (FSRT) Stereotactic Body Radiation Therapy (SBRT) Interstitial/Intracavitary Brachytherapy
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Young Kwok, M.D.
Scope of Clinical Practice Large academic medical center 250-300 patient consultations per year 150-180 patients treated per year Clinical Duties: 4 days/week, 12 months/year Development of Clinical Programs 2004-Present Developed a high-risk prostate cancer program Contribute the vast majority of patients to the Gamma Knife program 2004-Present Developed an active clinical trial programs in CNS, GU and Pediatric. 2009-Present Developed a pediatric oncology collaborative program with Children’s National Medical Center, Washington DC Clinical Trials University of Maryland Medical Center Protocols 2005 – 2006 PI Retrospective Chart Review of Patients who have undergone Permanent Interstitial Prostate Brachytherapy to Study the Correlation Between PreOperative CT Scan Beams-Eye-View Prostate Volume with Real-Time Intraoperative Ultrasound Prostate Volumes 2005 - 2006
PI GCC 0501: Retrospective Review of stereotactic Radiosurgery Treatments of Benign, Primary and Metastatic Lesions: A University of Maryland
Experience. 2006 - 2011
Co-PI (PI: David Eisenman, MD) Gamma Knife for Acoustic Neuroma Role: Helped design study. Enroll patients. Will assist in analyzing and publishing results.
2006 - present
PI GCC 0605: Phase II Study Evaluating Bone Marrow-Sparing, Image-Guided Pelvic Intensity-Modulated Radiotherapy (IMRT) with Cesium-131 Brachytherapy Boost, Adjuvant Chemotherapy, and Long-Term Hormonal Ablation in Patients with High Risk, Non-Metastatic Prostate Cancer.”
2013 - present
PI GCC 1224: Phase II Trial of Low-Dose Whole Brain Radiotherapy with Concurrent Temozolomide and Adjuvant Temozolomide in Patients with NewlyDiagnosed Glioblastoma Multiforme
2013 - present
PI GCC 1328: Retrospective Analysis of Salvage External Radiation Therapy in Patients with Recurrent Prostate Cancer after Brachytherapy
Principle Investigator of National/International Protocols 2013 - present Co-Chair, Alliance (CALGB)
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Young Kwok, M.D. RTOG 1115: Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Institutional Principle Investigator of National/International Protocols 2006 - 2009 RTOG 0320: A Phase III Trial Comparing Whole Brain Radiation and Stereotactic Radiosurgery Alone Versus with Temozolomide or Erlotinib in Patients with Non Small Cell Lung Cancer and 1-3 Brain Metastases 2007 - 2009
RTOG 0415: A Phase III Randomized Study of Hypofractionated 3DCRT/IMRT versus Conventionally fractionated 3D-CRT/IMRT in Patients with Favorable-risk Prostate Cancer.
2005 - 2009
RTOG 0424: A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas
2008 - present
RTOG 0526: A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy
2008 - present
RTOG 0534: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy
2008 - 2010
RTOG 0614: A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy
2008 - 2009
RTOG 0513: A Phase I/II Trial of Temozolomide, Motexafin Gadolinium, and 60 Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme
2008 - 2010
RTOG 0621: Adjuvant 3DCRT/IMRT in Combination with Androgen Suppression and Docetaxel for High Risk Prostate Cancer Patients PostProstatectomy: A Phase II Trial
2009 - 2011
RTOG 0825: Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide plus Bevacizumab versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma
2009 - 2012
RTOG 0539: Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate and High-Risk Meningiomas
2010 - present
RTOG 0815: Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediated-Risk Prostate Cancer.
2010 - 2012
RTOG 0831: A Randomized, Double-Blinded, Placebo-Controlled Phase III Trial to Evaluate the Effectiveness of a Phosphodiesterase 5 Inhibitor, Tadalafil,
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Young Kwok, M.D. in Prevention of Erectile Dysfunction in Patients Treated with Radiotherapy for Prostate Cancer. 2011 - present
RTOG 0929: A Randomized Phase I/II Study of ABT-888 in Combination With Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma
2011 - present
RTOG 0924: Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial
2011 – present
RTOG 0938: A Randomized Phase II Trial Of Hypofractionated Radiotherapy For Favorable Risk Prostate
2013 - present
RTOG 0913: Phase I/II Trial of Concurrent RAD001 (Everolimus) With Temozolomide/Radiation Followed by Adjuvant RAD001/Temozolomide in Newly Diagnosed Glioblastoma
2013 - present
RTOG 1205: Randomized Phase II Trial of Concurrent Bevacizumab and ReIrradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma
Institutional Co-Principle Investigator of National/International Protocols 2002 - 2008 RTOG 0126: A Phase III Randomized Study of High Dose 3D-CRT/IMRT versus Standard Dose 3D-CRT/IMRT in Patients Treated for Localized Prostate Cancer. 2003 - present
RTOG 0232: A Phase III Study Comparing Combined External Beam Radiation and Transperineal Interstitial Permanent Brachytherapy with Brachytherapy Alone for Selected Patients with Intermediate Risk Prostatic Carcinoma.
Administrative Service Institutional (UMSOM) 2004-Present Tumor Boards 2004-Present GU Tumor Board (Leader/Coordinator since March 2007) 2004-Present Solid Tumor Board 2004-Present CNS Tumor Board 2004-Present Lymphoma Tumor Board 2004-Present Pediatric Tumor Board 2007-2008 Base of Skull Tumor Board 2007-2009 Head and Neck Tumor Board 2004-Present Committees 2005-2009 Cancer Review Committee 2005-2011 Technology Review Committee 2010-2013 Radiation Oncology IT Committee 2010-2011 University of Maryland Dosimetry School Curriculum Committee 2010-Present University of Maryland Dosimetry School Advisory Committee 2011-Present Brachytherapy Committee 2004-Present Internal Residency/Fellowship Review 2004 Urology 2005 Interventional Cardiology 2004-Present UMSOM Admissions—Applicant Interviews, 10-15 per year 2004-Present Radiation Oncology Electronic Library
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Young Kwok, M.D. 2005-Present 2007-Present
Institutional Review Board, IRB Panel #4 (committee #1 starting 2013) Ask the Expert (www.umm.edu website) 2007-Present Spine-directed Oncology Program. http://www.umgcc.org/brain_tumor_center/spine-directed-oncology.htm 2009-Present Gamma Knife Center http://www.umm.edu/gammaknife/index.htm 2010-Present Prostate Seed Implant http://www.umgcc.org/gu_program/psi.htm
2008
Department of Radiation Oncology Research Retreat (April 2, 2008) Coordinated a research retreat, which included the subdivisions of physics, biology, and clinical faculty, with the following objectives: 1. To identify barriers and limitations that prevent effective clinical/translational research 2. To identify strategies to optimize effective interdepartmental research collaboration 3. To identify strategies to optimize effective inter-institutional research collaboration Acting Director of Clinical Research Department of Radiation Oncology, University of Maryland Medical Center Associate Director of Clinical Research Department of Radiation Oncology, University of Maryland Medical Center Cancer Interest Group Univ of Maryland-Baltimore/University of Maryland-College Park annual seed competition, reviewer Department of Radiation Oncology, Practice Guidelines Jan 17, 2012 CNS Cancers Mar 27, 2012 Lymphomas June 5, 2012 Gamma Knife Stereotactic Radiosurgery Associate Director of Residency Department of Radiation Oncology, University of Maryland Medical Center Director of Medical Student Rotations Department of Radiation Oncology, University of Maryland Medical Center Department of Radiation Oncology--Appointments, Promotions, Tenure Committee 2013 Nilesh Mistry, PhD (Instructor to Assistant Professor) Mariana Guerrero, PhD (Clinical Assistant to Clinical Associate Professor) Wei Lu, PhD (Assistant to Associate Professor) Yildirim Mutaf, PhD (Assistant to Associate Professor) Warren D’Souza, PhD (Associate Professor to Professor) 2014 Hao (Howard) Zhang, PhD (Instructor to Assistant Professor)
2008-2009 2009-2012 2009-2011 2011-2013 2012
2013 2013 2013
Local/Regional 2004-2007 Cancer Committee, Baltimore VA Medical Center, Baltimore, MD 2008-2009 White Oak Seminar Series: Coordinated a series of Radiation Oncology presentations at the FDA: Center for Devices and Radiological Health—The Federal Research Center @ White Oak, Silver Springs, MD March 26, 2008 Speaker: Young Kwok, M.D. Topic: Recent Advances in Radiation Oncology April 30, 2008 Speaker: Michael Garofalo, M.D.
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Young Kwok, M.D. Topic: Liver-directed Therapy Speaker: Majid Mohiuddin, M.D. Topic: Recent Advances in Breast Cancer August 27, 2008 Speaker: William Regine, M.D. Topic: Brain Metastases Management September 24, 2008 Speaker: Anil Dhople, M.D. Topic: Stereotactic Body Radiation Therapy February 25, 2009 Speaker: Pradip Amin, M.D. Topic: Brachytherapy Pediatric Tumor Boards, Children’s National Medical Center (Washington, DC) 2009-Present Pediatric Solid Tumor Board 2009-Present Pediatric CNS Tumor Board May 28, 2008
2009-Present
National/International 2011-Present Editorial Board, International Journals 2011-present The World Scientific Journal 2003-Present
Ad Hoc Reviewer, International Journals 2003-present Technology in Cancer Research and Treatment 2004-present American Journal of Clinical Oncology 2005-present International Journal of Radiation Oncology Biology Physics 2005-present Journal of Clinical Oncology 2006-present Spinal Cord 2007-present International Journal for Quality in Health Care 2007-present The Lancet Oncology 2007-present Cancer 2008-present Lung Cancer 2008-present Molecular Cancer Therapeutics 2011-present Mayo Clinic Proceedings
2005-11
Genito-urinary & Radiation Oncology Committees, Cancer and Leukemia Group B (CALGB), Chicago, Il Genito-urinary Committee Radiation Oncology Committee
2006-2007
University of Maryland Annual Radiobiology, Physics Review Course: Annual review course for the Radiation Oncology Written Board Exam attended by a majority of residents throughout the country. April 28-30, 2006 Co-coordinator May 3-6, 2007 Co-coordinator
2007-present
American Board of Radiology (Radiation Oncology) 2007 Genito-urinary written board examination writer 2008 Genito-urinary written board examination writer
2011-Present
Alliance for Clinical Trials in Oncology (merged group of CALGB, NCCTG, ACOSOG) Genito-urinary Committee Radiation Oncology Committee
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Young Kwok, M.D. Teaching Service Medical School Lectures (UMSOM, 15-20 students) 2001-11 Discussion Group Facilitator for second year medical school small group in oncology, one 2 hour class per year Clinical Teaching Duties (University of Maryland Medical Center) 2004-Present Attending Physician, inpatient/outpatient consults, outpatient clinic 1 resident, 10 hours/day, 4 days/week, 10-12 months/year Graduate School Lectures (University of Maryland, Baltimore, 10-15 students) 2008 GPIL 665 course - Special Topics in Cancer Biology Contemporary Management of Glioblastoma. 1.5 hr lecture--October 27, 2008 Course Director: Feyruz Rassool, Ph.D. Graduate Student Mentees (2hr/week for 2 weeks for each student): Dipika Germani, Final Project: Alternatives strategies in overcoming imatinib resistance in chronic myeloid leukemia patients. Amanda Graner, Final Project: The Role of the t(4; 14)(p16; q32) translocation in multiple myeloma 2009
GPIL 665 course - Special Topics in Cancer Biology CNS Tumor: Clinical Management. 1.5 hr lecture--October 26, 2009 Course Director: Feyruz Rassool, Ph.D.
2010
GPIL 665 course - Special Topics in Cancer Biology CNS Tumor: Clinical Management. 1.5 hr lecture—October 29, 2010 Course Director: Feyruz Rassool, Ph.D.
2011
GPIL 665 course - Special Topics in Cancer Biology CNS Tumor: Clinical Management. 1.5 hr lecture—November 14, 2011 Course Director: Feyruz Rassool, Ph.D.
2012
GPIL 665 course - Special Topics in Cancer Biology CNS Tumor: Clinical Management. 1.5 hr lecture—November 26, 2012 Course Director: Feyruz Rassool, Ph.D.
2013
GPIL 665 course - Special Topics in Cancer Biology CNS Tumor: Clinical Management. 1.5 hr lecture—November 25, 2013 Course Director: Feyruz Rassool, Ph.D. • Wrote and graded exams
Ph.D. Dissertation Committee 2008-2012 (2 hour/month) Candidate: Nneka Onwudiwe, University of Maryland School of Pharmacy Title: Breast Conserving Surgery: Event Free Survival and Costs Subsequent to Radiation Therapy Advisors: Ebere Onukwugha, Ph.D., C Daniel Mullins, Ph.D., Young Kwok, M.D. Proposal Defense: May, 2009 Ph.D. Thesis Defense: March 2012 Resident Lectures, Department of Radiation Oncology (1 hour, 10-15 Residents and Students)
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Young Kwok, M.D. April 20, 2005 June 12, 2007 Nov 20, 2007 Dec 4, 2007 Jan 2, 2008 Oct 7, 2008 Oct 28, 2008 April 22, 2009 April 29, 2009 Oct 7, 2009 March 17, 2010 October 5, 2010 May 4, 2011 May 11, 2011 March 28, 2012 May 9, 2012 March 20, 2013 May 8, 2013 Sept 19, 2013
Pediatric Medulloblastoma Metastatic Spinal Cord Compression Medulloblastoma Predictors of Outcome in Prostate Cancer Jeopardy: Genito-urinary Cancers Contemporary Management of Non-metastatic Prostate Cancer Jeopardy: Genito-urinary Cancers Radiation Sensitizers in Metastasis Jeopardy: Central Nervous System High-Risk Prostate Cancer Pediatric Ependymoma “Tie Breakers” in Prostate Cancer Pediatric Hodgkin’s Disease—Late Morbidity and Mortality Alternative Dose Delivery Systems Post-operative Radiation Therapy for Prostate Cancer Alternative Dose Delivery Systems Pediatric Jeopardy Alternative Dose Delivery Systems Post-Prostatectomy Radiation Therapy
University of Maryland Dosimetry School Lectures (1 hour, 2 dosimetry students) October 25, 2004 CNS Dosimetry-Treatment Planning April 23, 2008 CNS Tumors November 5, 2008 Base of Skull Tumors I November 12, 2008 Base of Skull Tumors II March 17, 2010 CNS–Glioblastoma Multiforme April 20, 2011 CNS–Glioblastoma Multiforme February 7, 2013 CNS–Glioblastoma Multiforme February 11, 2013 GU-Brachytherapy March 11, 2013 Prostate Cancer Resident Mock Oral Preparatory Exams, Department of Radiation Oncology (1 hour, exam/feedback) Sept 21, 2005 Genito-urinary. Anil Dhople M.D. Oct 24, 2006 Genito-urinary. Todd Flannery M.D. Jan 17, 2007 Central Nervous System. Todd Flannery M.D. Nov 28, 2007 Genito-urinary. Ashish Patel M.D. Jan 21, 2010 Central Nervous System, Geoffrey Neuner, M.D. April 28, 2010 Central Nervous System/Pediatrics, Ashish Patel M.D. April 28, 2010 Central Nervous System/Pediatrics, Ali Mirmiran M.D. October 25, 2010 Genito-urinary, Usama Mahmood, M.D. April 27, 2011 Central Nervous System/Pediatrics Navesh Sharma, M.D. Russell Hales, M.D. (Johns Hopkins) Kristen Redmon, M.D. (Johns Hopkins) Susannah Yovino, M.D. (Johns Hopkins) May 4, 2011 Central Nervous System/Pediatrics, Genito-urinary Navesh Sharma, M.D. Matthew Koshy, M.D.
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Young Kwok, M.D.
April 9, 2012 May 11, 2012
June 4, 2012 June 13, 2012 Oct 3, 2012 April 19, 2013
May 1, 2013
Kristen Redmon, M.D. (Johns Hopkins) Central Nervous System/Pediatrics, Sarah Grabowski, M.D. Central Nervous System/Pediatrics, Genito-urinary Geoffrey Neuner, M.D. (GBMC) Usama Mahmood, M.D. (MD Anderson Cancer Center) Randi Cohen, M.D. Genito-urinary, Grace Kim, M.D. Central Nervous System/Genito-urinary, Zain Husain, M.D. Central Nervous System/Genito-urinary, Elizabeth Nichols, M.D. Central Nervous System/Pediatrics, Genito-urinary Grace Kim, M.D. (Duke) Zain Husain, M.D. (Yale) Lara Bonner Millar, M.D. (Eastern Virginia) Genito-urinary, Benjamin Laser, M.D.
Student Research Sponsorships/Mentorships (2 hours/week) 2002-2003 Stephen Ronson, MS IV (University of Maryland School of Medicine) Topic: Incidence and temporal pattern of hematuria and proteinuria in men treated with permanent interstitial prostate brachytherapy. Results: • Presented at the American Radium Society, Houston, Tx, April 2003. • Matched residency program in Radiation Oncology at Loma Linda Hospital, CA. 2003-2004
Neeraja Murali, BA (University of Maryland College Park) Topic: Long-term Results of Gamma Knife Stereotactic Radiosurgery for Nonfunctioning Pituitary Adenomas. Results: • Presented at the American Society of Therapeutic Radiology and Oncology, Atlanta, Ga October 2004. • Entered graduate program in Epidemiology at Emory University, GA.
2003-2004
Susannah Yovino, MS IV (University of Maryland School of Medicine) Topic: Preoperative Anemia is Associated with Decreased Survival in Patients with Stage I and II Non-Small-Cell Lung Cancer Treated with Surgery. Results: • Presented at the American Society of Therapeutic Radiology and Oncology, Atlanta, Ga October 2004 • Manuscript published in International Journal of Radiation Oncology Biology Physics, 2005. • Matched residency program in Radiation Oncology at University of Maryland School of Medicine, MD.
2005-2007
Owen Thomas, MS III (University of Maryland School of Medicine) Topic: Long-term outcome of Gamma-Knife stereotactic radiosurgery for brain metastasis from radio-resistant tumors (melanoma, sarcoma, renal-cell carcinoma). Results: • Presented at the Radiological Society of North America, Chicago, Il, November 2006 • Matched in residency program in Radiation Oncology at Johns Hopkins Hospital, MD
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Young Kwok, M.D.
2005-2007
Lara Bonner, MS III (University of Maryland School of Medicine) Topic: Hematuria and Proteinuria in men treated with prostate brachytherapy. Results: Matched in residency program in Radiation Oncology at University of Pennsylvania Hospital, PA
2006-2007
Elizabeth Nichols, MS III (University of Maryland School of Medicine) Topic: Long-term outcome of patients with vestibular schwannoma treated with gamma Knife stereotactic radiosurgery. Results: • Matched in residency program in Radiation Oncology at University of Maryland Medical Center, MD
2009-2010
Tejan Diwanji, MS I Topic: Long-term outcome of multiple sclerosis patients with trigeminal neuralgia treated with Gamma-Knife stereotactic radiosurgery. Results: • Summer Fellowship Award in Radiation Oncology ($2500). Department of Radiation Oncology, University of Maryland School of Medicine • Presented at the American Society of Therapeutic Radiology and Oncology, San Diego, Ca October 2010
2009-2010
Sonu Bassi, Severn High School Student Topic: Long-Term Results of a Prospective, Phase II Study of Long-term Androgen Ablation,Pelvic Radiotherapy, Brachytherapy Boost and Adjuvant Docetaxel in Patients with High-Risk Prostate Cancer Results: • Manuscript accepted to the International Journal of Radiation Oncology Biology Physics, 2010. • Early admission to Johns Hopkins University
2010-present
Andrew Saltos, MS III Topic: Outcomes of AVM patients treated with Gamma Knife. Results: • Abstract accepted to the American Society for Radiation Oncology, 2011 annual meeting. • Manuscript published in Journal of Neurosurgery, 2012
2011-2012
Kevin Quinn, MS I Topic: Neurocognitive Function in Long-Term Survivors of Whole Brain Radiation Results: • American Brain Tumor Association Medical School Summer Fellowship ($3000). Department of Radiation Oncology, University of Maryland School of Medicine.
2012-present
Moshe Meister, MS I Topic: High-Risk Prostate Cancer, Salvage therapy for Brachytherapy Failures Results: • Oral Presentation, American Society for Radiation Oncology, 2013 annual meeting • Department of Radiation Oncology Summer Research Fellowship 2013
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Young Kwok, M.D. •
Submitted abstract for American Society for Radiation Oncology, 2014 annual meeting
2012-present
Matthew Ferris, MS III Topic: High-Risk Prostate Cancer, Preliminary Results of GCC 0605 Results: • Oral Presentation, American Society for Radiation Oncology, 2013 annual meeting • Matched for Radiation Oncology at Emory University
2013-present
Shivum Kumar, High School Student Topic: Proton Beam Therapy in Pediatric Patients: Photon vs Protons
Radiation Oncology Resident Research Sponsorships/Mentorships, Department of Radiation Oncology (2 hours/week) 2003-2004 Pinaki Dutta, MD (University of Pennsylvania Hospital) Topic: Comparison of Repeat GK-SRS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter? Results: • Presented at the American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004. 2004.2005
Anil Dhople, MD Topic: Evaluation of Efficacy and Quality of Life in Patients with Atypical Facial Pain Treated with Gamma-Knife Stereotactic Radiosurgery. Results: • Presented at the American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005 • Manuscript published. International Journal of Radiation Oncology Biology Physics, 2006.
2005-2006
Shilpen Patel, MD Topic: Evaluating the influence of dose-rate on outcome with gamma-knife stereotactic radiosurgery in the treatment of trigeminal neuralgia. Results: • Presented at the American Society of Therapeutic Radiology and Oncology, Denver, Co. October 2005.
2005-2006
Susannah Yovino, MD Topic: Long-term outcome of breast cancer patients treated with Gamma-Knife stereotactic radiosurgery for brain metastasis Results: • Presented at the Radiologic Society of North America, Chicago 2006.
2005-2006
Kathleen Settle, MD Topic: A Volumetric Study of Needle’s Eye View CT scan in Predicting Pubic Arch interference and Intra-operative Prostate Volume in Men Undergoing Permanent Interstitial ProstateBrachytherapy.
2005-2007
Anil Dhople, MD
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Young Kwok, M.D. Topic: Long-term outcome of Gamma-Knife stereotactic radiosurgery for brain metastasis from radio-resistant tumors (melanoma, sarcoma, renal-cell carcinoma). Results: • Presented at the Radiological Society of North America, Chicago, Il, November 2006 2005-2007
Todd Flannery, MD Topic: The Impact of Definitive Thoracic Management on Long-Term Survival in Patients with Synchronous, Solitary Brain Metastases from Non-Small Cell Lung Cancer Treated with Stereotactic Radiosurgery. Results: • Presented at the American Society of Therapeutic Radiology and Oncology, Philadelphia, PA 2006 • Manuscript published International Journal of Radiation Oncology Biology Physics, 2008.
2005-2008
Todd Flannery, MD Topic: Long-term Results of Intermediate and High-Risk Prostate Cancer Patients Treated with Prostate Brachytherapy Results: • Presented at the American Brachytherapy Society, Philadelphia, PA, May 2006 • Resident Travel Award for Dr. Flannery
2007-2008
Usama Mahmood, MD Topic: Dosimetric Analysis of Cesium-131 Brachytherapy. Results: • Presented at the American Brachytherapy Society, Boston, MA, May 2008.
2007-2009
Ali Mirmiran, MD Topic: Long-term Toxicity Data of a Prospective Phase I/II Trial of Concurrent Paclitaxel and Radiation for High-risk or Post-operative Prostate Cancer. Results: • Presented at American Society of Therapeutic Radiology and Oncology, Boston, MA, 2008.
2007-2009
Ali Mirmiran, MD Topic: Long-Term Results of a Prospective, Phase II Study of Long-term Androgen Ablation, Pelvic Radiotherapy, Brachytherapy Boost and Adjuvant Docetaxel in Patients with High-Risk Prostate Cancer Results: • Manuscript accepted to International Journal of Radiation Oncology Biology Physics, 2010.
2007-2010
Ashish Patel, MD Topic: University of Maryland Experience of Gliasite Brachytherapy in Recurrents High-grade Gliomas. Results: • Presented at the Radiologic Society of North America, Chicago, Il, 2008.
2008-2010
Matthew Koshy, MD Topic: Utilization and Impact of Radiation Therapy in Stage I and II Hodgkin’s Disease
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Young Kwok, M.D. Results: • Presented at the American Radium Society, Cancun, Mexico, May 2010 • Young Investigator Award • Will be presented at the American Society of Therapeutic Radiology and Oncology, San Diego, CA, October 2010 • Manuscript accepted to International Journal of Radiation Oncology Biology Physics, 2010. 2009-2010
Grace Kim, MD Topic: Outcomes of AVM patients treated with Gamma Knife.
2011-present
Elizabeth Nichols, MD Topic: Brain Metastasis—Perez Book Chapter update
2013-present
Michael Rutenberg, M.D., Ph.D. Topic: Salvage external beam radiation in prostate brachytherapy failures Results: • Submitted abstract for American Society for Radiation Oncology, 2014 annual meeting
2013-present
Alexander Engelman, M.D. Topic: HIV and Prostate Cancer; Long Term Update of GCC 0166—High Risk Prostate Cancer Results: • Submitted abstracts for American Society for Radiation Oncology, 2014 annual meeting
2013-present
James Snider, M.D. Topic: Long Term Update of GCC 0166—High Risk Prostate Cancer Results: • Submitted abstract for American Society for Radiation Oncology, 2014 annual meeting
Clerkship Director, Children’s National Medical Center (Washington, DC) Pediatric Oncology Fellows (40 hours/week) May 10-14, 2010 Fellow: Yaser Diab, M.D. June 28-July 2, 2010 Fellow: Andrzek Rochowski, M.D. June 28-July 2, 2010 Fellow: Helkha Peredo-Pinto, M.D. July 26-30, 2010 Fellow: Burak Gumuscu, M.D March 11-18, 2011 Fellow: Leslie Doros, M.D. March 11-18, 2011 Fellow: Theresa Watson, M.D. June 27-July 1, 2011 Fellow: Karim Sadak, M.D. August 15-19, 2011 Fellow: Caitlin Neri, M.D. July 23-27, 2012 Fellow: Surbhi Saini, M.D. July 23-27, 2012 Fellow: Megha Kaushal, M.D. July 31-Aug 3, 2012 Fellow: Violet Fernandes, M.D. July 31-Aug 3, 2012 Fellow: Payal Khincha, M.D. July 29-Aug 2, 2013 Fellow: Nicole Drezner, M.D. July 29-Aug 2, 2013 Fellow: Bahey Salem, M.D.
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Young Kwok, M.D. August 19-23, 2013 August 19-23, 2013 Grant Support June 2006 – June 2011
Long-Term Non-Metastatic Prostate
Aug 2008 – Aug 2010
Fellow: Ekta Kapadia Fellow: Sucharita Bhaumik
PI (5 %) Phase II Study Evaluating Bone Marrow-Sparing, Image-Guided Pelvic Intensity-Modulated Radiotherapy (IMRT) with Cesium-131 Brachytherapy Boost, Adjuvant Chemotherapy, and Hormonal Ablation in Patients with High Risk, Cancer. Industry Grant: Isoray Corp., Richland, WA Total Direct and Indirect Costs: $200,000 PI (0 %)
A Phase I Study Evaluating Escalating Doses of Docetaxel Concurrently with Bone Marrow-Sparing, Image-Guided Pelvic Intensity-Modulated Radiotherapy (IMRT) and Long-Term Androgen Ablation in Patients with High-Risk, Non-Metastatic Prostate Cancer. Seed Grant: Cancer and Leukemia Group B (CALGB) Total Direct and Indirect Costs: $88,000 Sept 2010 – Sept 2011
Co-PI (0 %; PI – Rao Gullapalli, PhD) GCC 1008: Neuroimaging Correlates in Evaluating Cognitive Function Following Radiation Therapy. U of MD Dept of Radiation Oncology Pilot Project Project Award Total Direct and Indirect Costs: $50,000 (no salary, imaging only) Pending CRC/IRB approvals Role: Assisted in the design of the study. Will enroll patients. Will assist in analyzing and publishing results.
Sept 2010 – Sept 2011
Co-PI (0 %; PI – France Carrier, PhD) Radiosensitizing Effect of Histone Deacetylase Inhibitors for the Treatment of Glioblastoma Multiforme with Low-Dose Radiation Therapy (LDFRT) in Combination with
Fractionated Radiation Therapy
U of MD Dept of Radiation Oncology Pilot Project Award Total Direct and Indirect Costs: $50,000 (post-doc support) Role: Assisted in designing the basic science research. Based on these results, phase I/II trial was designed—currently enrolling. Publications Peer-Reviewed Journal Articles 1. Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S. Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy. International Journal of Radiation Oncology Biology Physics 2002, 53(3), 588-594. 2. Flannery T, Suntharalingam M, Kwok Y, Koffman B, Amin P, Chin L, Nicol B, Fowler B, Young AB, Regine W. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer 2003, 42, 327-333.
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Young Kwok, M.D. 3. Thomas L, Kwok Y, Edelman M. Management of paraneoplastic syndromes in lung cancer. Current Treatment Options in Oncology 2004, 5(1), 51-62. 4. Herman JM, Petit JH, Amin P, Kwok Y, Dutta P, Chin LS. Repeat gamma knife radiosurgery for refractory or recurrent trigeminal neuralgia: Treatment outcomes and quality of life assessment. International Journal of Radiation Oncology Biology Physics 2004, 59(1), 126-133. 5. Garofalo M, Kwok Y, Regine WF. The Evolving Role of Adjuvant Postoperative Radiation Therapy. Surgical Oncology Clinics of North America 2004 Oct;13(4):589-604, viii. 6. Patel AB, Edelman MJ, Kwok Y, Krasna M, Suntharalingam M. Predictors of acute esophagitis in patients with non-small cell lung carcinoma treated with concurrent chemotherapy and hyperfractionated radiation therapy followed by surgery. International Journal of Radiation Oncology Biology Physics 2004 Nov;60(4),1106-12. 7. DiBiase S, Kwok Y, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. International Journal of Radiation Oncology Biology Physics 2004 Nov 15;60(4):1106-12. 8. Kwok Y, Regine WF, Patchell RA. Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo. Journal of Clinical Oncology 2005 May 20;23(15):3308-10. Epub 2005 Feb 28.] 9. Yovino S, Kwok Y, Krasna M, Bangalore M, Suntha M. An association between preoperative anemia and decreased survival in early-stage non-small cell lung cancer treated with surgery alone. International Journal of Radiation Oncology Biology Physics 2005 Aug 1;62(5):1438-4. 10. Ma L, Kwok Y, Chin LS, Simard JM, Regine WF. Concomitant GRID boost for Gamma Knife radiosurgery. Medical Physics 2005 Nov;32(11):3419-23. 11. Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife radiosurgery for trigeminal neuralgia treatments. Phys Med Biol 2005 Nov 21;50(22):5217-27. Epub 2005 Oct 24. 12. D’Souza W, Kwok Y, DeYoung C, Zacharapoulos N, Pepelea M, Klahr P, and Yu CX. Gated CT imaging using a free-breathing respiration signal from flow-volume spirometry. Medical Physics 2005 Dec;32(12):3641-49. 13. Kwok Y, DeYoung C, Garofalo M, Dhople A, and Regine W. Radiation Oncology Emergencies. Hematology/Oncology Clinics of North America April 2006;20(2):505-522. 14. Kwok Y, Tibbs PA, Patchell RA. Clinical approach to metastatic epidural spinal cord compression. Hematology/Oncology Clinics of North America Dec 2006;20(6):1297-1305. 15. D’Souza W, Nazareth D, Zhang B, Deyoung C, Suntharalingam M, Kwok Y, Yu CX, and Regine W. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy. Medical Dosimetry 2007 Summer;32(2):92-101. 16. Dhople A, Kwok L, Chin L, Shepard D, Slawson R, Amin P, and Regine W. Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery. Int J Radiat Oncol Biol Phys 2007;69(2):397-403. Epub 2007 Apr 30. 17. Flannery TW,Suntharalingam M, Regine WF, Chin LS, Krasna MJ, Shehata MK, Edelman MJ, Kremer M, Patchell RA, and Kwok Y. Long-term survival in patients with synchronous, solitary brain metastasis from non-small cell lung cancer treated with radiosurgery. Int J Radiat Oncol Biol Phys 2008 Sept 1;72(1):19-23. Epub 2008 Feb 13. 18. Dhople AA, Adams JR, Maggio WW, Naqvi SA, Regine WF, and Kwok Y. Long Term Outcomes of Gamma-Knife Radiosurgery for Classic Trigeminal Neuralgia: Implications of Treatment and Critical Review of the Literature. J Neurosurg 2009: 1-8. Epub 2009 March 27. 19. Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Carter K, Ord R, Zimrin A, Strome S, and Suntharalingam M. Race impacts outcome in stage III/IV squamous cell carcinomas of the head and neck after concurrent chemoradiation therapy. Cancer 2009; 115(8):1744-52. 20. Yovino S, Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Ord R, Zimrin A, Strome S,and Suntharalingam M. Patterns of failure among patients with squamous cell carcinoma of the head and
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Young Kwok, M.D. neck who obtain a complete response to chemoradiotherapy. Head Neck 2010;32(1):46-52. Epub 2009 May 29. 21. Kwok Y, Yovino S. Radiation-based therapies for prostate cancer. Curr Opin Oncol 2010 May;22(3):257-62. 22. DiBiase SJ, Hussain A, Kataria R, Amin P, Bassi S, Dawson N, and Kwok Y. Long-term results of a prospective, phase II study of long-term androgen ablation, pelvic radiotherapy, brachytherapy boost and adjuvant docetaxel in patients with high-risk prostate cancer. International Journal of Radiation Oncology Biology Physics 2011;81(3):732-6. Epub 2010 Oct30. 23. Hussain A, Wu Y, Mirmiran A, DiBiase S, Goloubeva O, Bridges, Mannuel H, Engstrom C, Dawson N, Amin P and Kwok Y. Long-term follow-up of a prospective trial of trimodality therapy of weekly paclitaxel, radiation and androgen deprivation in high risk prostate cancer with or without prior prostatectomy. International Journal of Radiation Oncology Biology Physics 2012;82(1):167-74. Epub 2010 Oct 30. 24. Szerlip N, Rutter C, Ram N, Yovino S, Kwok Y, Maggio W, Regine W. Factors impacting volumetric white matter changes following whole-brain radiation therapy. Journal of NeuroOncology 2011;103(1):111-9. Epub 2010 Aug 20 25. Koshy M, Rich SE, Mahmood U, Feigenberg S, and Kwok Y. The Declining Utilization of Radiation Therapy in Stage I and II Hodgkin's Disease and its Impact on Survival and Secondary Malignancies. In Press. International Journal of Radiation Oncology Biology Physics 2011. 26. Suntharalingam M, Kwok Y, Goloubeva O, Parekh A, Taylor R, Wolf J, Zimrin A, Strome S, Ord R, and Cullen K. A Phase II Study Evaluating the Addition of Cetuximab to the Concurrent Delivery of Weekly Carboplatin, Paclitaxel and Daily Radiotherapy for Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck. International Journal of Radiation Oncology Biology Physics 2011 May 19. [Epub ahead of print] 27. Koshy M, Rich S, Merchant E, Mahmood U, Regine W, and Kwok Y. Post-operative Radiation Improves Survival in Children Younger Than 3 Years with Intracranial Ependymoma. Journal of Neuro-oncology. 2011;105(3):583-90. Epub 2011 June 3. 28. Husain ZA, Regine WF, Kwok Y and Feigenberg SJ. Brain Metastases: Contemporary Management and Future Directions. The European Journal of Clinical & Medical Oncology. June 2011, 3(3). 3845. 29. Koltz MT, Polifka AJ, Saltos A, Slawson RG, Kwok Y, Aldrich EF, and Simard JM. Long-Term Outcome of Gamma Knife Stereotactic Radiosurgery for Arteriovenous Malformations Graded by the Spetzler-Martin Classification. Journal of Neurosurgery 2012;Oct 19. [Epub ahead of print].
30. Diss E, Nalabothula N, Nguyen D, Chang E, Kwok Y, and Carrier F. Vorinostat SAHA Promotes Hyper-Radiosensitivity in Wild Type p53 Human Glioblastoma Cells. JSM Clin Oncol Res 2014; 2(1): 1004. 31. Tye K, Engelhard HH, Slavin KV, Nicholas MK, Chmura SJ, Kwok Y, Ho DS, Weichselbaum RR, Koshy M. An analysis of radiation necrosis of the central nervous system treated with bevacizumab. J Neurooncol 2014; Feb 7. [Epub ahead of print]. Non-refereed: 1. Kwok Y, Patchell RA. Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.� Doh, Amato, Paulino et al. Oncology May 2006;20(6):619625. Book Chapters: 1. Kwok Y, Garofalo M, Regine WF. Postoperative Adjuvant Therapy for Pancreatic Cancer. In: Pancreatic Cancer. Von Hoff DD, Evans DB, and Hruban RH (ch.27, p395-404). Sudbury, MA: Jones and Barlett, 2005.
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Kwok Y, Patchell RA, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Principles and Practice of Radiation Oncology (ch.91, p1974-1985). Lippincott Williams & Wilkins; 5th edition. 2007. Miker-Zabel S, Kwok Y, Debus J. Skull Base Tumors. In: Principles and Practice of Stereotactic Radiosurgery (ch.37, p383-392). Springer; 1st edition. 2008 Chin LS, Patel S, Mattingly T, Kwok Y. Trigeminal Neuralgia. In: Principles and Practice of Stereotactic Radiosurgery (ch.52, p519-526). Springer; 1st edition. 2008 Kwok Y, Patchell RA, Regine WF. Management of Overt CNS Metastases: Brain and Spinal Cord. Lung Cancer: Principles and Practice. Lippincott Williams & Wilkins; 4th edition. April 2010. Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: ALERT: Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. Rubin P, Constine L, Marks L, Williams J, Hansen J. New York, NY: Springer-Verlag, 2012. Nichols E, Patchell RA, Regine WF, Kwok Y. Palliation of Brain and Spinal Cord Metastases. In: Principles and Practice of Radiation Oncology. Lippincott Williams & Wilkins; 6th edition. 2013
Other Brief Communications: 1. Kwok Y, Regine W, Dibiase SJ. In reply to Dr. Rogers et al. International Journal of Radiation Oncology Biology Physics 2005 Jun 1;62(2):618-9. 2. Kwok Y, Patchell RA, Regine W. In reply to Dr. Macbeth et al and Dr. Maranzano et al. Journal of Clinical Oncology 2005;23(32):8272-8275. 3. Mahmood U, Kwok Y, Regine WF, and Patchell RA. Whole brain irradiation for patients with brain metastasis: still the standard of care. Lancet Oncol 2010;11(3):221-2. Abstracts/Presentations (Selected): 1. Kwok Y, Lanzkowsky P, Karayalcin G. Childhood neutropenias: A fifteen year experience. Poster Presentation at American Society of Hematology, Miami, Fl, December 1998. 2. Kennedy A, Murthy R, Kwok Y, Kanani S, Tucker G, Desai K, van Echo D. Preliminary results of outpatient hepatic artery brachytherapy for colorectal hepatic metastases. Oral Presentation at European Cancer Conference, Lisbon, Portugal, October 2001. 3. Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S. Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy. Oral Presentation at Radiological Society of North America, Chicago, Il, October 2001. 4. Kennedy A, Murthy R, Kwok Y, Tucker G, Kanani S, Desai K, van Echo D. Hepatic artery brachytherapy for unresectable hepatocellular carcinoma: an outpatient treatment approach. Oral Presentation at Internation Congress on Anti-Cancer Treatment, Paris, France, February 2002. 5. Kwok Y, Suntharalingam M, Taylor R, Baig F, Yaes R, Mohiuddin M, Regine W. A definitive evaluation of the impact of treatment related factors on local control in patients with T1 glottic tumors utilizing Linear-Quadratic Plus Time model. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2002. 6. Kennedy A, Yovino S, Kwok Y, Duckham E, van Echo D. Long-term follow-up of upper GI cancers after conformal radiotherapy combined with paclitaxel or capecitabine plus paclitaxel. Oral Presentation at Radiological Society of North America, Chicago, Il, November 2002. 7. Ronson S, DiBiase S, Kwok Y, Amin P, Naslund M, Jacobs S. Incidence and temporal pattern of hematuria and proteinuria in men treated with permanent interstitial prostate brachytherapy. Poster Presentation at American Radium Society, Houston, Tx, April 2003. 8. Kwok Y, DiBiase S, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Improved outcome with adequate dural tail coverage in patients with intracranial meningiomas treated with Gamma Knife stereotactic radiosurgery. Poster Discussion at American Society of Therapeutic Radiology and Oncology, Salt Lake City, Ut, October 2003
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Kennedy A, Kwok Y, Batko-Yovino S, van Echo D. A phase I study of preoperative capecitabine, irinotecan concurrent with radiation therapy for resectable rectal cancer. Poster Presentation. American Society of Clinical Oncology GI Symposium, San Francisco, Ca, January 2003. Yovino S, BA, Kwok Y, Krasna M, Bangalore M, Suntha M. Preoperative Anemia Decreases Survival in Patients with Stage I and II Non-Small-Cell Lung Cancer Treated with Surgery. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004. Kwok Y, Murali N, Chin L, Bangalore M, Amin P, and Regine W. Long-term Results of Gamma Knife Stereotactic Radiosurgery for Non-functioning Pituitary Adenomas. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004. Dutta, P.R., Kwok Y, Chin, L.S., Herman, J.M., Colliver, C., St. Clair, W., Petit, J., Young, B., and Regine, W.F. Comparison of Repeat GK-SRS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter? Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004. Sullivan P, Ord R, Gray W, Wolf J, Taylor R, VanEcho D, Kwok Y, Suntharalingam M. Long-term survival and functional quality of life assessments in patients with locally advanced unresectable squamous cell carcinomas of the head and neck treated with concurrent chemoradiation. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Atlanta, Ga, October 2004. Patel S, Kwok Y, Shepard D, Chin L, Slawson R, Amin P, and Regine W. Evaluating the influence of dose-rate on outcome with gamma-knife stereotactic radiosurgery in the treatment of trigeminal neuralgia. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005. SJ DiBiase, N Dawson, Y Kwok, R Kataria, A Hussain, S Nagda, M Bangalore, P Amin. Phase II Trial of External Radiotherapy, Brachytherapy, Androgen Deprivation, and Docetaxel Chemotherapy for High-Risk, Localized Prostate Cancer. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005. Dhople A, Kwok Y, Jaboin J, Chin L, Slawson R, Amin P and Regine W. Evaluation of Efficacy and Quality of Life in Patients with Atypical Facial Pain Treated with Gamma-Knife Stereotactic Radiosurgery. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Denver, Co, October 2005. Flannery T, Kwok Y, Naslund M, and Amin P. Long-term Results of Intermediate and High-Risk Prostate Cancer Patients Treated with Prostate Brachytherapy. Poster Presentation (Resident Travel Grant for Todd Flannery, M.D.) at American Brachytherapy Society, Philadelphia, PA, May 2006. Flannery T, Kwok Y, Krasna L, Chin L, Shehata M, Kremer M, Jaboin J, Suntha M, Regine W. The Impact of Definitive Thoracic Management on Long-Term Survival in Patients with Synchronous, Solitary Brain Metastases from Non-Small Cell Lung Cancer Treated with Stereotactic Radiosurgery. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Philadelphia, Pa, November 2006. Thomas O, Kwok Y, Dhople A, Chin L, Slawson, Regine W, Long-term outcome of patients treated with Gamma Knife stereotactic radiosurgery for brain metastases secondary to malignant melanoma or renal cell carcinoma. Poster Presentation at Radiological Society of North America, Chicago, Il, November 2006 Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Carter K, Ord R, Zimrin A, Strome S and Suntharalingam M. Race Impacts Outcome in Stage III/IV Squamous Cell Carcinomas of the Head and Neck Following Concurrent Chemoradiation Therapy. Poster Discussion at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007. Kwok Y, Won M, Regine WF, Mehta M, Schmitt F, Patchell RA, and Watkins-Bruner D. Neurocognitive Impact of Whole Brain Radiation on Patients With Brain Metastases: Secondary Analysis of RTOG BR-0018. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007.
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Young Kwok, M.D. 22. Adams JR, Dhople AA, Kwok Y, Yu XU, Simard JM, Maggio W and Regine. Long Term 23.
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Follow-up of Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007. Dhople AA, Adams JR, Kwok Y, Yu XU, Simard JM, Maggio W and Regine WF. Long Term Follow-up of Repeat Gamma Knife Stereotactic Radiosurgery for Refractory or Recurrent Trigeminal Neuralgia. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007. Carter K, Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Ord R, Zimrin A, Strome S and Suntharalingam. Site as a Prognostic Factor in Patients with Stage III/IV Squamous Cell Carcinoma of the Head and Neck Following Definitive Chemoradiation. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007. Yovino S, Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Ord R, Zimrin A, Strome s and Suntharalingam M. Can Adjuvant Neck Dissection be Deferred in Locally Advanced Head and Neck Cancer Patients With Complete Response to Definitive Chemoradiotherapy? Oral Presentation at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007. Patel AB, Edelman M, Burrows W, Hausner P, Kwok Y, Krasna M and Suntharalingam M. The Impact of Prophylactic Cranial Irradiation in Patients with Locally Advanced Non-Small Cell Lung Cancer Treated With Trimodality Therapy. Poster Discussion at American Society of Therapeutic Radiology and Oncology, Los Angeles, November 2007. Kwok Y, Kataria R, Amin P, Naslund M, Hussain A, Dawson N, and Dibiase S. Long-term Results of a Prospective Phase II Trial of Androgen Ablation, Pelvic External Beam Radiation Therapy, Brachytherapy Boost, and Adjuvant Docetaxel in High-risk Prostate Cancer. Oral Presentation at American Society of Therapeutic Radiology and Oncology, Boston, Ma, September 2008. Mahmood U, Richards L, D'Souza W, Naslund M, Amin P and Kwok Y. Dosimetric Analysis of the Effect of Prostate Edema on Cs-131 Brachytherapy. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Boston, Ma, September 2008. Yovino SB, Rutter C, Szerlip N, Kwok Y, Maggio W and Regine WF. Long-term Survivors of Brain Metastases (BM) Have Optimal Brain Tumor Control with Combined Whole Brain Radiation (WBRT) and Stereotactic Radiosurgery (SRS). Poster Presentation at American Society of Therapeutic Radiology and Oncology, Chicago, Il, Noveber 2009. Koshy M, Rich S, Merchant T, Regine W and Kwok Y. Postoperative Radiation Improves Overall Survival in Children Age <3 Years with Intracranial Ependymoma. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Chicago, Il, November 2009. Diwanji T, Dhople A, Chin L, Maggio W, Adams J, Regine W and Kwok Y. Long-term Outcome of Gamma Knife Stereotactic Radiosurgery for Multiple Sclerosis Associated Trigeminal Neuralgia. Poster Presentation at American Society of Therapeutic Radiology and Oncology, San Diego, Ca, November 2010. Kwok Y, Wu Y, Mirmiran A, DiBiase S, Goloubeva O, Bridges B, Mannuel H, Dawson N, Amin P and Hussain A. Prospective Trial of Escalating Doses of Paclitaxel, Concurrent Radiation and Androgen Deprivation in High Risk Prostate Cancer With or Without Prior Prostatectomy. Longterm Outcome of Gamma Knife Stereotactic Radiosurgery for Multiple Sclerosis Associated Trigeminal Neuralgia. Poster Presentation at American Society of Therapeutic Radiology and Oncology, San Diego, Ca, November 2010. Regine W, Szerlip N, Rutter C, Ram N, Yovino S, Maggio W and Kwok Y. Factors Impacting White Matter Changes Following Whole Brain Radiation Therapy. Poster Presentation at American Society of Therapeutic Radiology and Oncology, San Diego, Ca, November 2010. Saltos A, Koltz M, Aquino C, Obuchowski A, Kim G, Kwok Y, and Simard J. Staged-dose radiosurgical outcomes for symptomatic and asymptomatic intracranial arteriovenous
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Young Kwok, M.D. malformations. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Miami, Fla, October 2011. 35. Carrier F, Diss E, Nalabothula N, and Kwok Y. The histone deacetylase inhibitor vorinostat induces hyper-radiosensivity in P53 wild type glioblastoma cells. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Miami, Fla, October 2011. 36. Kwok Y, Saltos A, Boggs D, Naslund M, Hussain A, and Amin P. Long-term follow-up of combined modality therapy with pelvic external radiation followed by Cs-131 brachytherapy boost in men with high-risk prostate cancer. Poster Presentation at American Society of Therapeutic Radiology and Oncology, Boston, Ma, October 2012. 37. Kwok Y, Ferris M, Moshe M, Kataria R, Nickerson C. Interim Results of a Prospective Phase II Trial of Pelvic IMRT, Cesium-131 Brachytherapy Boost, Adjuvant Docetaxel Chemotherapy, and Long Term Androgen Ablation for Patients with High Risk Prostate Cancer. Oral Presentation at American Society for Radiation Oncology, Atlanta, Ga 2013. Proffered Communications: 1. Kwok Y, M Won, WF Regine, M Mehta, F Schmitt, RA Patchell, and D Watkins-Bruner. Neurocognitive Impact of Whole Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR-0018. Oral Presentation at Radiation Therapy and Oncology Group, San Diego, Ca, January 19, 2008. Invited Speeches 1. February 12, 2002 2.
November 5, 2003
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January 21, 2004
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March 9, 2004
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June 19, 2004
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October 15, 2004
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October 15, 2004
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Contemporary Management of Supratentorial High-Grade Gliomas. Grand Rounds. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. Introduction to Radiation Oncology. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Univ of Maryland Medical CenterCME Lecture. Baltimore, MD. Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. CME Lecture. Bethesda, MD. Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. CME Lecture. Annapolis, MD. Contemporary Management of Central Nervous and Head and Neck Tumors. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. Diagnosis and Treatment of Trigeminal Neuralgia. Greater Baltimore Medical Center, Baltimore, MD. Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Greater Baltimore Medical Center, Baltimore, MD. Diagnosis and Treatment of Trigeminal Neuralgia. Cambridge Dental Group, Cambridge, MD. Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: University of Maryland Experience. Cambridge Dental Group, Cambridge, MD. Diagnosis and Treatment of Trigeminal Neuralgia. Holy Cross Hospital, Silver Spring, MD. Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia:
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University of Maryland Experience. Holy Cross Hospital, Silver Spring, MD. The Role of Radiotherapy in Genito-urinary Malignancies. Grand Rounds. Division of Urology, UMSOM, Baltimore, MD. Introduction to Radiation Oncology. National Youth Leadership Forum. University of Maryland Medical Center, Baltimore, MD Lymphoma Review. Annual Mid-Atlantic American Society of Therapeutic Radiology Oncology Review. UMSOM, Baltimore, MD Management of Brain Metastasis from Lung Cancer. UMSOM Annual Thoracic Malignancy Update, Cambridge, MD Management of Spinal Cord Compression. European Society of Therapeutic Radiology and Oncology, Leipzig, Germany CNS Review. Annual Mid-Atlantic American Society of Therapeutic Radiology Oncology Review. UMSOM, Baltimore, MD Stage I and II Seminoma. Solid-Tumor Board. University of Maryland Medical Center, Baltimore, MD Prostate Cancer: Treatment Overview. Solid-Tumor Board. University of Maryland Medical Center, Baltimore, MD Prostate Cancer: Determinants of Outcome. Solid-Tumor Board. University of Maryland Medical Center, Baltimore, MD Whole Brain Radiation Therapy in the Management of Brain Metastasis from Non-small Cell Lung Cancer. American Society of Clinical Oncology, Chicago, Il CNS Malignancies. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD. Prostate Cancer: Treatment Overview. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD Genito-urinary Review. Annual Mid-Atlantic American Society of Therapeutic Radiology Oncology Review. UMSOM, Baltimore, MD Chemoradiation in Locally-Advanced Cervical Cancer. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD Recent Technological Advances in Radiation Oncology. FDA: Center for Devices and Radiological Healthâ&#x20AC;&#x201D;The Federal Research Center @ White Oak, Silver Springs, MD Contemporary Management of Non-metastatic Prostate Cancer. Grand Rounds. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD Contemporary Management of Non-metastatic Prostate Cancer. Grand Rounds. Division of Urology, UMSOM, Baltimore, MD CNS Review. Annual Mid-Atlantic American Society of Therapeutic Radiology Oncology Review. UMSOM, Baltimore, MD Introduction to Radiation Oncology. University of Maryland Radiation Oncology Interest Group. Univ of Maryland School of Medicine, Baltimore, MD High-Risk Prostate Cancer: Are We There Yet? Grand Rounds. Laurel Regional Hospital, Laurel, MD. Prostate: Technological Advances. UMMC Consumer Seminar Series Pikesville Hilton, Pikesville, MD. Introduction to Radiation Oncology. University of Maryland Radiation
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Oncology Interest Group. Univ of Maryland School of Medicine, Baltimore, MD Recent Technological Advances in Radiation Oncology. Grand Rounds. Childrenâ&#x20AC;&#x2122;s National Medical Center. Washington, DC. Recent Advances in Radiation Oncology for GU Cancers. Grand Rounds. Upper Chesapeake Medical Center, Bel Air, MD. Contemporary Management of Muscle-Invasive Bladder Cancer. Grand Rounds. Greenebaum Cancer Center, Univ of Maryland Medical Center, Baltimore, MD GU Review. Annual Mid-Atlantic American Society of Therapeutic Radiology Oncology Review. UMSOM, Baltimore, MD Role of Radiation Therapy in Pituitary Adenomas. Endocrinology Fellows Lecture. Division of Endocrinology, Univ of Maryland Medical Center, Baltimore, MD Trigeminal Neuralgia. Grand Rounds. Dept of Neurosurgery, Univ of Maryland Medical Center, Baltimore, MD Post-Prostatectomy Radiation. Grand Rounds. Division of Urology, Univ of Maryland Medical Center, Baltimore, MD PSA Screening Controversy. Grand Rounds. Internal Medicine. Harbor Hospital, Baltimore, MD Role of Brachytherapy in High-Risk Prostate Cancer. Visiting Professor. Grand Rounds. Georgetown University. Washington, DC. Extent of Resection in Brain Tumors. Grand Rounds. Dept of Neurosurgery, Univ of Maryland Medical Center, Baltimore, MD PSA Screening Controversy. Grand Rounds. Internal Medicine. Laurel Regional Hospital, Baltimore, MD GU Review. Annual Mid-Atlantic American Society of Therapeutic Radiology Oncology Review. UMSOM, Baltimore, MD
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