CURRICULUM VITAE Patrick F. McArdle, Ph.D. Assistant Professor, Department of Medicine University of Maryland School of Medicine
Date
November 16, 2010
Personal Information Division of Endocrinology, Diabetes & Nutrition Department of Medicine University of Maryland School of Medicine Room 300E, MSTF Building Baltimore, MD 21201 Phone Number: (410) 706-4180 Fax Number: (410) 706-1622 E-mail Address: pmcardle@medicine.umaryland.edu Education 5/1994 12/2006
B.S. Cornell University (Mechanical and Aerospace Engineering) Ph.D. University of Maryland, Baltimore (Epidemiology)
Employment History Faculty Appointments 1/2007-
3/2008-
Assistant Professor Department of Medicine Division of Endocrinology, Diabetes & Nutrition University of Maryland School of Medicine Secondary Appointment Department of Epidemiology and Public Health University of Maryland School of Medicine
Employment History, Academic 4/2005-12/2006
Information Systems Engineer Department of Medicine Division of Endocrinology, Diabetes & Nutrition University of Maryland Baltimore School of Medicine
Curriculum Vitae Patrick F. McArdle Page 2
Employment History, Industry 3/1996-10/1996 1/1997-4/1998 4/1998-3/2000 3/2000-4/2002
Engineer, BW/IP International Inc., San Jose, California Engineer, OEM Manager, Rammer Inc., Baltimore, Maryland Consultant, Technical Lead, Computer Science Corporation, Falls Church, Virginia Consultant, Lead Designer, Blue Martini Software, Redwood City, California
Professional Society Memberships 20042005-2007
American Society of Human Genetics International Genetic Epidemiology Society
Honors and Awards 2010
University of Maryland, Baltimore Graduate Program in Epidemiology and Public Health Teaching Excellence Award
Administrative Service Institutional 2004-2005 200720092010-
Graduate Program Committee, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine Faculty Mentor, Epidemiology of Aging Training Program Education Committee, Division of Endocrinology, Diabetes and Nutrition Comprehensive Exam Committee, Program in Epidemiology
Local 20032009-
Chairman, Sylvan Beach Foundation Board of Directors, Baltimore Taharka Brothers Ice Cream Company Board of Directors, Baltimore
National 2007200720082008200820092009-
Aging Research Reviews; Reviewer Diabetes / Metabolism Research and Reviews, Reviewer Cancer, Reviewer Arthritis and Rheumatism, Reviewer International Journal of Obesity, Reviewer American Journal of Epidemiology, Reviewer Diabetes, Reviewer
Curriculum Vitae Patrick F. McArdle Page 3 2010Teaching Service 2007-2010
2007
2007-present
2008-2010 2008 2009 2010-present
Scandinavian Journal of Rheumatology, Reviwer
Lecturer Principles of Epidemiology (PREV600) 1st Yr Gradute Students Group Leader Pharmacogenimcs Clinical Correlation Excerise 2nd Yr Medical Students Faculty Member Pre and Post Doctoral Trainees Epidemiology of Aging Training Program Lecturer Chronic Disease Epidemiology (PREV 789) Lecturer Genetic Epidemiology (PREV 711) Co-Course Leader Genetic Epidemiology (PREV 711) Course Leader Genetic Epidemiology (PREV 711)
Mentoring Service 2010
2010-present
Primary Mentor Graham Osborn, Medical Student Smartphone Accessibility Survey Student Advisor Jennifer Ginsberg Degree program in Epidemiology and Human Genetics
Grant Support : Active 03/01/06 – 02/28/11 NIDDK R01DK073490 The International 1q Type 2 Diabetes Consortium PI: Alan Shuldiner, M.D. (Oxford subagreement) Current Direct/Indirect Costs: $176,962/$85,827 Total Direct/Indirect Costs: $887,916/$430,640 09/01/07-06/30/11
NHLBI R01HL088119
Curriculum Vitae Patrick F. McArdle Page 4 Genetic Influences on Coronary Artery Calcification PI: Braxton Mitchell, Ph.D. 01/01/09-12/31/10
American Diabetes Association 1-08-CR-60 Steriod Challenge and the Development of Post Transplant Diabetes Mellitus PI: Kristi Silver, M.D.
09/30/09-08/31/11
NIH RC2GM092729 Metabolomics Network for Drug Response Phenotype PI: Kaddurah-Daouk, Ph.D.
09/30/09-09/29/13
NIH U01NS069208 The NINDS Ischemic Stroke Genetics Consortium PI: Steve Kittner, M.D.
05/01/10-05/01/12
NIH P60DK07637 Hyperandrogenemia and Polycystic Ovarian Syndrome in the Amish PI: Patrick McArdle, Ph.D. and Sara DiVall, M.D.
09/03/2010-05/31/13 NIH 1K30RR22682 Clinical Research Curriculum Award PI: Mary Claire Roghmann, M.D.
Completed 07/2002-06/05
NIA T32 AG000262 Effort: 100% Research Training in the Epidemiology of Aging PI: Jay Magaziner, Ph.D., M.S.Hyg. Annual Direct/Indirect Costs: $210,668/$14,392 Total Direct/Indirect Costs: $1,028,450/$69,965
04/01/04-03/31/09
NIDDK R01DK054261 Genetics of Diabetes in the Amish PI: Alan Shulidner, M.D.
Curriculum Vitae Patrick F. McArdle Page 5 Current Direct/Indirect Costs: $435,114/$211,030 Total Direct/Indirect Costs: $2,215,004/$1,061,181 07/01/05 – 06/30/10 NHLBI R01HL076768 Cloning a Blood Pressure Gene on Chromosome 2q32.3 PI: Nanette Steinle, M.D. Current Direct/Indirect Costs: $345,831/$167,728 Total Direct/Indirect Costs: $1,413,879/$675,163 07/01/08-06/30/10
NIH U01HG004436 Genetic Risk to Stroke in Smokers and Nonsmokers PI: Braxton Mitchell, Ph.D.
06/15/06-05/31/10
NHLBI U01HL084756 Genome-Wide Association in Families: Data Integrity, Design, and Methods Issue PI: Jeffrey O’Connell, D.Phil Current Direct/Indirect Costs: $200,000/$86,980 Total Direct/Indirect Costs: $600,000/$248,264
Patents, Inventions, and Copyrights 1. Wang Y, McArdle PF, Dorff S, Mitchell BD, Shuldiner AR, Chang YPC. Genetic Variants in the Hypertension Susceptibility STK39 Gene and Uses Thereof. International Patent Number: PCT/US09/002438
Publications Peer Reviewed Journal Articles 1. McArdle PF, Pollin TI, O’Connell JR, Sorkin JD, Agarwala R, Schäffer AA, Streeten EA, King TM, Shuldiner AR, Mitchell BD. Does having children extend lifespan? A genealogical study of parity and longevity in the Amish. J Gerontol A Biol Sci Med Sci. 2006 Feb;61(2):190-5. PMID: 16510865 2. Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4d Polymorphisms And The Risk Of Cerebral Infarction In A Biracial Population: The Stroke Prevention In Young Women Study. Hum Mol Genet. 2006 Aug 15;15(16):2468-78. Epub 2006 Jul 11. PMID: 16835261
Curriculum Vitae Patrick F. McArdle Page 6
3. McArdle PF, O’Connell JR, Pollin TI, Baumgarten M, Shuldiner AR, Peyser PA, Mitchell BD. Accounting for relatedness in family based genetic association studies. Hum Hered 2007;64:234-242. PMID: 16510865 4. Rampersaud E, Damcott CM, Fu M, Shen H, McArdle PF, Shi X, Shelton J, Yin J, Chang CY, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: Evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes. 2007 Dec;56(12):3053-62. PMID: 17846126 5. McArdle PF, Dytch H, O’Connell JR, Shuldiner AR, Peyser PA, Mitchell BD, Abney M. Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture. BMC Genetics 2007, 8:66 (1 October 2007). PMID: 17908314 6. Mitchell BD, McArdle PF, Shen H, Rampersaud E, Pollin TI, Bielak LF, Jaquish C, Douglas JA, Roy-Gagnon MH, Sack P, Naglieri R, Hines S, Horenstein RB, Chang YPC, Post W, Ryan KA, Brereton NH, Pakyz RE, Sorkin J, Damcott CM, O’Connell JR, Mangano C, Corretti M, Vogel R, Herzog W, Weir MR, Peyser PA, Shuldiner AR. The genetic response to short-term interventions affecting cardiovascular function: Rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study. Am Heart Journal. 2008 May;155(5):823-8. PMID: 18440328 7. McArdle PF, Rutherford S, Mitchell BD, Damcott CM, Wang Y, Ott S, Chang YPC, Levy D, Shuldiner AR, Steinle N. Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study. BMC Medical Genetics 2008, 9:67. PMID: 18625075 8. McArdle PF, Parsa A, Chang YPC, Weir MR, Mitchell BD, Shuldiner AR. Association of a Common Nonsynonymous Variant in GLUT9 With Serum Uric Acid Levels in Old Order Amish. Arthritis & Rheumatism. 2008 Sept; 58(9):2874-2881. PMID: 18759275 9. McArdle PF, Whitcomb BW. Improper adjustment for baseline: A potential cause of non replication in short term intervention studies of gene by environment interactions. Human Heredity 2008 Dec 15;67(3):176-182. PMID: 19077436 10. Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RS, Mitchell BD, Shuldiner AR, Chang YP. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):226-31. PMID: 19114657 11. Baumgarten M, Margolis DJ, Orwig DL, Shardell MD, Hawkes WG, Langenberg P, Palmer MH, Jones PS, McArdle PF, Sterling R, Kinosian BP, Rich SE, Sowinski J, Magaziner J.
Curriculum Vitae Patrick F. McArdle Page 7 Pressure Ulcers in Elderly Hip Fracture Patients Across the Continuum of Care. Journal of American Geriatrics Society. 2009 May;57(5):863-70. PMID: 19484841 12. Sanna S, Busonero F, Maschio A, McArdle PF , Usala G, Dei M, Lai S, Mulas A, Piras MG, Perseu L, Masala M, Marongiu M, Crisponi L, Naitza S, Galanello R, Abecasis GR, Shuldiner AR, Schlessinger D, Cao A, Uda M. Genome-wide association scan shows common variants in the SLCO1B3 locus associated with bilirubin levels and unconjugated hyperbilirubinemia. Human Molecular Genetics. Advance Access published on May 6, 2009 PMID: 19419973 13. Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MN, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath E, Uitterlinden AG, Murabito JM. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics. Nat Genet. 2009 May 17. PMID: 19448620 14. Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR, Bielinski SJ, Boerwinkle E, Brancati F, Demerath EW, Pankow JS, Arnold AM, Chen YD, Glazer NL, McKnight B, Psaty BM, Rotter JI, Amin N, Campbell H, Gyllensten U, Pattaro C, Pramstaller PP, Rudan I, Struchalin M, Vitart V, Gao X, Kraja A, Province MA, Zhang Q, Atwood LD, Dupuis J, Hirschhorn JN, Jaquish CE, O'Donnell CJ, Vasan RS, White CC, Aulchenko YS, Estrada K, Hofman A, Rivadeneira F, Uitterlinden AG, Witteman JC, Oostra BA, Kaplan RC, Gudnason V, O'Connell JR, Borecki IB, van Duijn CM, Cupples LA, Fox CS, North KE. NRXN3 is a Novel Locus for Waist Circumference: A Genome-wide Association Study from the CHARGE Consortium. PLoS Genet. 2009 Jun;5(6) PMID: 19557197 15. Baumgarten M, Margolis D, Orwig D, Hawkes W, Rich, S, Langenberg P, Shardell MD, Palmer MH, McArdle P, Sterling R, Jones PS, Magaziner J. Use of Pressure-Redistributing Support Surfaces Among Elderly Hip Fracture Patients Across the Continuum of Care: Adherence to Pressure Ulcer Prevention Guidelines. The Gerontologist. 2010 Apr;50(2):25362.. PMID: 19587108 16. Cheng YC, Kao WL, Mitchell BD, O’Connell JR, Shen H, McArdle PF, Gibson Q, Ryan KA, Shuldiner AR, Pollin TI. Genome-wide Association Scan Identifies Variants near Matrix Metalloproteinase (MMP) Genes on Chromosome 11q21-22 Strongly Associated with Serum MMP-1 Levels. Circ Cardiovasc Genet. 2009 Aug;2(4):329-37. Epub 2009 May 14. PMID: 20031604
Curriculum Vitae Patrick F. McArdle Page 8 17. Kosova G, Pickrell JK, Kelley JL, McArdle PF, Shuldiner AR, Abney M, Ober C. The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate. PLoS Genet. 2010 Jun 3;6(6). PMID: 20532200 18. Musunuru K, Post WS, Herzog W, Shen H, O'Connell JR, McArdle PF, Ryan KA, Gibson Q, Cheng YC, Clearfield E, Johnson AD, Tofler G, Yang Q, O'Donnell CJ, Becker DM, Yanek LR, Becker LC, Faraday N, Bielak LF, Peyser PA, Shuldiner AR, Mitchell BD. Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 With Platelet Reactivity: A Potential Mechanism for Increased Vascular Disease. Circ Cardiovasc Genet. 2010 Oct 1;3(5):445-453. PMID: 20858905. 19. Shen H, Damcott CM, Rampersaud E, Pollin TI, Horenstein R, McArdle PF, Peyser PA, O’Connell JR, Bielak LF, Post W, Chang Y-P C, Ryan KA, Miller M, Shelton J, Shuldiner AR, Mitchell BD. Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the Old Order Amish. Arch Intern Med 170(20):1850-1855, 2010. PMID: 21059979 20. Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, Gudbjartsson DF, Esko T, Feenstra B, Hottenga JJ, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SH, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PK, Smith EN, Ulivi S, Warrington NM, Zgaga L, Alavere H, Amin N, Aspelund T, Bandinelli S, Barroso I, Berenson GS, Bergmann S, Blackburn H, Boerwinkle E, Buring JE, Busonero F, Campbell H, Chanock SJ, Chen W, Cornelis MC, Couper D, Coviello AD, d'Adamo P, de Faire U, de Geus EJ, Deloukas P, Döring A, Smith GD, Easton DF, Eiriksdottir G, Emilsson V, Eriksson J, Ferrucci L, Folsom AR, Foroud T, Garcia M, Gasparini P, Geller F, Gieger C; GIANT Consortium, Gudnason V, Hall P, Hankinson SE, Ferreli L, Heath AC, Hernandez DG, Hofman A, Hu FB, Illig T, Järvelin MR, Johnson AD, Karasik D, Khaw KT, Kiel DP, Kilpeläinen TO, Kolcic I, Kraft P, Launer LJ, Laven JS, Li S, Liu J, Levy D, Martin NG, McArdle WL, Melbye M, Mooser V, Murray JC, Murray SS, Nalls MA, Navarro P, Nelis M, Ness AR, Northstone K, Oostra BA, Peacock M, Palmer LJ, Palotie A, Paré G, Parker AN, Pedersen NL, Peltonen L, Pennell CE, Pharoah P, Polasek O, Plump AS, Pouta A, Porcu E, Rafnar T, Rice JP, Ring SM, Rivadeneira F, Rudan I, Sala C, Salomaa V, Sanna S, Schlessinger D, Schork NJ, Scuteri A, Segrè AV, Shuldiner AR, Soranzo N, Sovio U, Srinivasan SR, Strachan DP, Tammesoo ML, Tikkanen E, Toniolo D, Tsui K, Tryggvadottir L, Tyrer J, Uda M, van Dam RM, van Meurs JB, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Weedon MN, Wichmann HE, Willemsen G, Wilson JF, Wright AF, Young L, Zhai G, Zhuang WV, Bierut LJ, Boomsma DI, Boyd HA, Crisponi L, Demerath EW, van Duijn CM, Econs MJ, Harris TB, Hunter DJ, Loos RJ, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Uitterlinden AG, Widen E, Murabito JM, Ong KK, Murray A. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet. 2010 Dec;42(12):107785.
Curriculum Vitae Patrick F. McArdle Page 9 21. Bartholomew M, McArdle PF. Causing Infringement. Vanderbilt Law Review. 2011 Apr;64(3):675-748.
Abstracts 1. McArdle PF, Pollin TI, Shuldiner AR, Mitchell BD. The relationship between parity and longevity in the Old Order Amish, a population characterized by large family sizes. American Society of Human Genetics 2004, Toronto, CA 2. McArdle PF, O’Connell JR, Shuldiner AR, Mitchell BD. Empirical power comparison of genetic association tests accounting for and ignoring familial relatedness. International Genetic Epidemiology Society 2005, Park City, UT. 3. Wang Y, Shi J, McArdle PF, Damcott C, Chang C, Shuldiner AR, Mitchell BD., Steinle, N. Genetic variation in the endothelin converting enzyme-like 1 gene is associated with type 2 diabetes (T2DM) in the Old Order Amish. American Society of Human Genetics 2006, New Orleans, LA. 4. McArdle PF, Rampersaud E, Mitchell BD. Lifespan after the death of a spouse in the Old Order Amish. Poster. University of Maryland Aging Research and Women’s Health 2006, Baltimore, MD. 5. McArdle PF, O’Connell JR, Shuldiner AR, Mitchell BD., Abney M. Homozygosity mapping in the Old Order Amish identifies a region of Chromosome 3 as linked to obesity related traits. American Society of Human Genetics 2006, New Orleans, LA. 6. Rampersaud E, Damcott CM, Mitchell BD, McArdle PF, Shelton J, Ying J, Fu M, Shi J, Zhao Y, Ott S, O’Connell J, Shuldiner AR. Identification of novel candidate genes for type 2 diabetes from a 100K genome-wide association scan in the Old Order Amish: Evidence for replication from diabetes-related quantitative traits and from independent populations. American Diabetes Association, 2007, Chicago, Illinois. 7. McArdle PF, Rutherford S, Mitchell BD, Damcott CM, Wang Y, Ott S, Chang YPC, Larson M, Levy D, Shuldiner AR, Steinle N. Nicotinic acetylcholine receptor subunit variants on chromosome 2q are associated with blood pressure related traits in the Old Order Amish and the Framingham Heart Study. American Heart Association, 61st Annual High Blood Pressure Research Conference 2007, Tucson, Arizona. 8. McArdle PF, Wang Y, Rutherford S, O'Connell JR, Ott SH, Reinhart LJ, Pollin TI, Damcott C, Chang YC, Mitchell BD, Shuldiner AR, Steinle N. Positional cloning of genes influencing blood pressure on chromosome 2q31-q36 in the Old Order Amish. American Society of Human Genetics 2007, San Diego, CA
Curriculum Vitae Patrick F. McArdle Page 10 9. Wang Y, McArdle PF, Rampersaud E, Shen H, Shi X, Steinle NI, Mitchell BD, Shuldiner AR, Chang YC. Whole-genome association study in the Old Order Amish identifies STK39 as a novel hypertension susceptibility gene. American Society of Human Genetics 2007, San Diego, CA 10. Cheng Y, Kao WHL, Shuldiner AR, Mitchell BD, McArdle PF, Shen H, Ryan K, Pollin TI. Genome wide association analysis identifies SNPs near MMP1 and MMP3 as being strongly associated with matrix metalloproteinase-1 (MMP1) levels: The Amish Heredity and Phenotype Intervention (HAPI) Heart Study. American Society of Human Genetics 2007, San Diego, CA 11. Parsa A, Rampersaud E, Mitchell BD, Horenstein R, McArdle PF, Shen H, O’Connell JR, Vogel R, Shuldiner AR. A genome-wide association study of brachial flow mediated dilation identifies novel candidate genes. American Society of Human Genetics 2007, San Diego, CA 12. Shen H, Damcott CM, Rampersaud E, Pollin TI, O’Connell J, Horenstein R, McArdle PF, Peyser P, Bielak L, Post W, Chang CY, Ryan K, Miller M, Shelton J, Shuldiner AR, Mitchell BD. The APOB R3527Q is common in the Old Order Amish and is a major cause of increased LDL-C concentrations and coronary artery calcification. American Heart Association Scientific Sessions 2007, Orlando, FL 13. Y. Wang, P. F. McArdle, X. Shi, C. M. Damcott, Y. C. Chang, B. D. Mitchell, A. R. Shuldiner, N. I. Steinle. Variation in ABCA12 is associated with blood pressure and partially accounts for the BP linkage on 2q in the Old Order Amish. American Society for Human Genetics 2008, Philadelphia, PA 14. T. I. Pollin, H. Ling, P. F. McArdle, Q. Gibson, B. D. Mitchell, J. R. O'Connell, A. R. Shuldiner. Genome-wide association study reveals ADIPOQ variation as strongest genetic influence on circulating adiponectin levels in the Old Order Amish. American Society for Human Genetics 2008, Philadelphia, PA 15. Y. Chang, Y. Wang, J. O'Connell, P. McArdle, J. Wade, S. Dorff, S. Shah, X. Shi, L. Pan, E. Rampersaud, H. Shen, J. Kim, A. Subramanya, N. Steinle, P. Welling, C. Ober, A. Weder, A. Chakravarti, B. Mitchell, A. Shuldiner. Common variants in STK39 are associated with blood pressure levels. American Society for Human Genetics 2008, Philadelphia, PA 16. A. Murray, J. Perry, L. Stolk, N. Franceschini, K.L. Lunetta, G. Zhai, P.F. McArdle, A.V. Smith, E. Streeten, T.B. Harris, T.D. Spector, E. Demerath, A.G Uitterlinden, J. Murabito, D. Lawlor, K. Northstone, M. Maisonet, M. McGeehin, C. Rubin, M. Marcus. Chromosome 9q31.2 locus is associated with onset of puberty in both males and females. American Society for Human Genetics 2009, Honolulu HI 17. Q.D. Gibson, P.F. McArdle. Hypothesis Mining: A web based query tool utilizing relational databases to mine GWAS results. American Society for Human Genetics 2009, Honolulu HI
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18. Yerges-Armstrong LM, McArdle PF, Pollin TI, Shuldiner AR, Mitchell BD. More Low Hanging Fruit on the Family Tree? Searching for Rare Sequence Variants in Families. International Genetic Epidemiology Society. 2009, Kahuku Hawaii 19. A. Parsa, E. Brown, MR. Weir, BD. Mitchel, AR. Shuldiner, PF. McArdle. Uric acid is causally associated with blood pressure in a controlled setting: results from a Mendelian randomization analysis of GLUT9. American Society of Nephrology 2010. Denver, CO. 20. Parsa A, Brown E, Weir MR, Mitchel BD, Shuldiner AR, McArdle PF. Uric acid is causally associated with blood pressure in a controlled setting: results from a Mendelian randomization analysis of GLUT9. American Society Human of Human Genetics. 2010, Washingotn D.C. Oral presentation.
Major Invited Speeches 1. Wake Forest University Health Sciences, Department of Biostatistical Sciences. Winston Salem, N.C. June 2008. Mendelian randomization and a demonstration of the GWAS results website in action. 2. Pharmacogenetics Research Network (PGRN) Research in Progress Seminar Series. Webinar. March 2009. A web based tool for mining GWAS results 3. NHLBI PROGENI Analysis Workshop. Baltimore, MD. June 2009. User-friendly web based GWAS tools. 4. University of Buffalo, School of Law. Buffalo, N.Y. March 2010. Borrowing from Epidemiology to Build a Better Definition of Cause In-Fact. 5. International Stroke Genetics Consortium Meeting. Leuven, Belgium. June 2011. An application of causal inference techniques to genetic association studies of stroke.