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Curriculum Vitae Aiping Zhao, M.D. Associate Professor, Medicine University of Maryland School of Medicine Date 12/16/2013 Contact Information Business Address:
Division of Translational Radiation Sciences Department of Radiation Oncology 10 S. Pine St, MSTF, Room 7-00D Baltimore, MD 21201 Business Phone Number: 401-706-5517, 410-706-5514 Fax: 410-706-2828 E-mail: azhao@mbrc.umaryland.edu Education 1983
M.D.
Jiangxi Medical College, Medicine, China
1988
M.S.
Xuzhou Medical College, Biochemistry, China
Post Graduate Education and Training 1995-1996
Visiting Scientist, Department of Biochemistry, Sun Yat-Sen University of Medical Sciences, Guangzhou, China. Mentor: Dr. Jianqun Ma
1998-1999
Postdoctoral Fellow, Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Mentor: Dr. Xiaoming Zhou
1999-2002
Postdoctoral Fellow, Division of Gastroenterology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Mentor: Dr. Terez Shea-Donohue
Employment History 1983-1985
Research Assistant, Department of Medical Chemistry, Jiangxi Medical College, Nanchang, China.
1988-1995
Lecturer, Department of Biochemistry, Guangdong College of Pharmacy, Guangzhou, China.
1996-1998
Associate Professor, Vice Chairman, Department of Biochemistry, Guangdong
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College of Pharmacy, Guangzhou, China. 2002-2004
Research Associate, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
2004-2012
Assistant Professor, Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of medicine, Baltimore, Maryland
2012-present Associate Professor, Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of medicine, Baltimore, Maryland 2013-present Associate Professor, Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of medicine, Baltimore, Maryland
Professional Society Memberships 2000-present
Member, The American Gastroenterological Association
2000-present
Member, The American Neurogastroenterology and Motility Society
2011-present
Life Member, Society of Chinese Bioscientists in America
2011-present
Life Member, Chinese Biopharmaceutical Association, USA
Honors and Awards 1999
Fellows Research Forum Award, National Kidney Foundation of the National Capital Area.
2000
Young Investigator Award, American Motility Society.
2001
Young Investigator Award, International Group for Neurogastroenterology and Motility.
2002
Travel Award, American Motility Society.
Administrative Service Institutional Service 2009-present
Organize and co-ordinate the GI Research Conference for the Division of Gastroenterology and Hepatology
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Local and National Service National Service 2006
Member, Abstract Review Committee, “Neuroimmune Modulation of Gut Function”, American Gastroenterological Association/Digestive Disease Week.
2007
Member, Abstract Review Committee, “Infection, Inflammation and Immune Modulation of Gut Motility”, American Gastroenterological Association/Digestive Disease Week.
2007
Chair, “Infection, Inflammation and Immune Modulation of Gut Motility”, American Gastroenterological Association/Digestive Disease Week, Washington DC
2008
Member, Abstract Review Committee, “Neuroimmune Modulation of Gut Function” American Gastroenterological Association/Digestive Disease Week.
2008
Chair, “Neuroimmune Modulation of Gut Function”, American Gastroenterological Association/Digestive Disease Week, San Diego
2008
Reviewer, Development and Feasibility Grant Program for International Centers for Research on Complementary Medicine, University of Maryland and Chinese University of Hong Kong
2009
Member, Abstract Review Committee, “Neuroimmune Regulation of Gut Function” American Gastroenterological Association/Digestive Disease Week.
2009
Chair, “Neuroimmune Regulation of Gut Function”, American Gastroenterological Association/Digestive Disease Week, Chicago
2010
Member, Abstract Review Committee, “Neuroimmune Modulation of Gut Function, Inflammation, and Infection”, American Gastroenterological Association/Digestive Disease Week.
2010
Chair, “Neuroimmune Modulation of Gut Function, Inflammation, and Infection”, American Gastroenterological Association/Digestive Disease Week, New Orleans
2010
Chair, “Ileus, Sepsis, Critical Care, and Dysmotility and Peripheral Opioid Antagonist”, International Meeting in Neurogastroenterology and Motility, Boston
2011
Member, Abstract Review Committee, “Inflammation, Injury and Neuroimmune Interactions”, American Gastroenterological Association/Digestive Disease Week.
2011
Member, Abstract Review Committee, “Hormones, Transmitters, Growth Factors and Their Receptors”, American Gastroenterological Association/Digestive
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Disease Week. 2011
Chair, “Luminal Chemosensing and the Brain-Gut Axis in Metabolic Homeostasis”, American Gastroenterological Association/Digestive Disease Week, Chicago
2012
Member, Abstract Review Committee, “Hormones, Transmitters, Growth Factors and Their Receptors”, American Gastroenterological Association/Digestive Disease Week.
2012
Member, Abstract Review Committee, “Metabolic Stress and Homeostasis”, American Gastroenterological Association/Digestive Disease Week.
2013
Member, Abstract Review Committee, “Hormones, Transmitters, Growth Factors and Their Receptors”, American Gastroenterological Association/Digestive Disease Week.
2013
Member, Abstract Review Committee, “Metabolic Stress and Homeostasis”, American Gastroenterological Association/Digestive Disease Week.
2007-present Regular or Ad Hoc Reviewer for Gastroenterology, American Journal of Physiology, Neurogastroenetrology and Motility, Infection and Immunity, Gut, Journal of Gastroenterology and Hepatology, Clinical and Experimental Pharmacology and Physiology, Archivum Immunologiae, Journal of Dairy Science, Evidence-based Complementary and Alternative Medicine, Critical Reviews in Immunology, PLOS one, Life Science 2011-
Editorial Board Member, American Journal of Immunology
Local Service 2007 Ad Hoc Reviewer, Development and Feasibility Grant Program for International Centers for Research on Complementary Medicine (ICRC), University of Maryland and Chinese University of Hong Kong 2011
Ad Hoc Reviewer, for “Enterics Research Investigational Cooperative Centers (ERIN)” pilot projects, University of Maryland ERIN CRC.
Teaching Service Undergraduate Student Teaching 1983-1985
Teaching Assistant, 6 hours/week, Medical Chemistry, Jiangxi Medical College, Nanchang, China
1988-1995
Lecturer; 12 hours/week, Biochemistry, Guangdong College of Pharmacy, Guangzhou, China
1995-1998
Associate Professor, Course Director, 12 hours/week, Biochemistry, Guangdong
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College of Pharmacy, Guangzhou, China Graduate Student Teaching 2011
Instructor, “Independent Study” class for graduate student 2 hours/week for 4 weeks Teaching “Innate and Adaptive immunity”
2011
Assistant Course Director and instructor, “GPILS 750, Current Topics in Molecular Medicine”; also teaching “Inflammatory Bowel Disease” 1.5 hours/week for 2 weeks
2012
Course co-Director and instructor, “GPILS 750, Current Topics in Molecular Medicine”; also teaching “Inflammatory Bowel Disease” 1.5 hours/week for 2 weeks
2013
Course Director and instructor, “GPILS 750, Current Topics in Molecular Medicine”; also teaching “Inflammatory Bowel Disease” 1.5 hours/week for 2 weeks
Graduate Student Mentoring and Indirect Teaching 2008
Research Mentor: Jessica Shu, M.D./Ph.D. student 2 hours/day for 2 months Teaching the student research techniques and supervising on a research project. Based on the work, the student presented an abstract at the annual meeting of American Gastroenterological Association/Digestive Disease Week 2009. The abstract was published in Gastroenterology, 2009, 136(5): A-719
2008-2013
Committee Member, Research Mentor: Jennifer Stiltz, Ph.D. student 3 hours/week Teaching/supervising the student research techniques, experimental design, data collecting and analyzing, etc
2009-present Committee Member, Research Mentor: Rex Sun, Ph.D. student 3 hours/week Teaching/supervising the student research techniques, experimental design, data collecting and analyzing, etc 2010-present Research Mentor: Leon Mclean, M.D./Ph.D. student 2 hours/week Teaching/supervising the student research techniques, experimental design, data collecting and analyzing, etc 2011
Qualifying Examination Committee Member: Drew Roberts, Ph.D. student; Sarah Horvat, Ph.D. student; Craig Sturgeon, Ph.D student
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Resident and Fellow Teaching 2001-2002
Research Mentor: Christopher Swiecki, M.D., Surgical Fellow from WRAMC 2 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2002-2003
Research Mentor: Sunny K. Whiteman, M.D., Surgical Fellow from WRAMC 3 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2002-2003
Research Mentor: Karla Au Yeung, M.D., Pediatric Fellow from WRAMC 2 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2003-2004
Research Mentor: Bradford J. Scanlan, M.D., Surgical Fellow from WRAMC 2 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2003-2004
Research Mentor: Minela Fernandez, M.D., Pediatric Fellow from WRAMC 2 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques Research Mentor: Blaine A. Tuft, M.D., Pediatric Fellow from WRAMC 2 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2004-2005
2005-2006
Research Mentor: Thomas L. Sutton, M.D., Pediatric Fellow from WRAMC 2 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2006-2007
Research Mentor: Diana C. Riera, M.D., Pediatric Fellow from WRAMC 3 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2009-2010
Research Mentor: Justin Devito, M.D., Pediatric Fellow from WRAMC 3 hours/week, 10 months Teaching the fellow cellular and molecular biology techniques
2010
Introduction to Basic Research ~20 students, including clinical and post-doctoral fellows 1.5 hour Teaching “Mucosal Immunology-Mucosal Barrier Function”
2011
Introduction to Basic Research ~15 students, including clinical and post-doctoral fellows 1.5 hour Teaching “Mucosal Immunology-Mucosal Barrier Function”
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2012
Introduction to Basic Research ~10 students, including clinical and post-doctoral fellows 1.5 hour Teaching “Mucosal Immunology-Mucosal Barrier Function”
2013
Introduction to Basic Research ~10 students, including clinical and post-doctoral fellows 1.5 hour Teaching “Mucosal Immunology-Mucosal Barrier Function”
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Post-Graduate Teaching 2010-2012
Mentor of Postdoctoral Fellow: Zhonghan Yang, Ph.D. 10 hours per week Teaching/supervising research design, research techniques, data collecting/analyzing, manuscript/abstract preparation, presentation, etc
2012-present Mentor of Postdoctoral Fellow: Anjiang Wang, M.D. 10 hours per week Teaching/supervising research design, research techniques, data collecting/analyzing, manuscript/abstract preparation, presentation, etc 2012-present Mentor of Visiting Scholar: Yanfei Li, M.S. Teaching/supervising research design, research techniques, data collecting/analyzing, manuscript/abstract preparation, presentation, etc Grant Support Active Grants 06/01/2009-03/31/2014
Aiping Zhao (Principal Investigator, 65%) “Novel Cytokine Regulation of Gut Function and Inflammation” NIH/NIDDK R01 DK083418 Annual Direct Costs: $215,000 Total Direct Costs: $1,025,000
07/01/2010-06/30/2015
Aiping Zhao (Senior Faculty; PI: Jean-Pierre Raufman) “Research Training in Gastroenterology” NIH/NIDDK 1 T32 DK067872-01 Total Direct Costs: $2,000,000
12/12/2007-12/11/2012 (NCE)
Aiping Zhao (co-Investigator, 5%; PI: Terez Shea-Donohue) “GI Nematodes and Gut Functional Responses to Inflammation" NIH/NIAID R01 AI49316 Annual Direct Costs: $250,000 Total Direct Costs: $1,250,000
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10/01/2010-10/01/2015
Aiping Zhao (co-Investigator, 30%; PI: Tom MacVittie) “Medical Countermeasures against Radiological Threats: Product Development Support Services" NIH/NIAID HHSN2662009079C Annual Direct Costs: $ Total Direct Costs: $
Completed Grants 07/22/2009-06/30-2010
Aiping Zhao (co-Investigator; PI: Terez Shea-Donohue) “Novel Therapy for Post-Irradiation Insult to Gut Mucosa in NonHuman Primates” NIH/NIAID 3RC1AI078520-01S109 Total Direct Costs: $225,000
10/01/2008-09/30/2010
Aiping Zhao (PI) “GI nematode infection, stress, and colorectal hypersensitivity” A pilot project under the International Center for Research on Complimentary Medicine (peer-reviewed), funded by NICAM Total Direct Costs: $20,000
06/18/2009-05/31/2013
Aiping Zhao (co-Investigator of Project 4, 10%; PI of Project 4: Alessio Fasano; PI: Marcelo Sztein) “Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animals” NIH/NIAID 1U19AI082655-01 Annual Direct Costs of Project 4: $205,000 Total Direct Costs of Project 4: $1,025,000
07/20/2010-06/30/2013
Aiping Zhao (co-Investigator of Project 2, 10%; PI of Project 2: Alessio Fasano; PI: James Kaper) “Enterics Research Investigational Cooperative Centers (ERIN)”, Project 2: Host Response NIH/NIAID 1U19AI090873-01 Annual Total Costs of Project 2: $300,899
Publications Peer-reviewed journal articles 1. Zhao, A. and Chao, S.H. Effects of Heavy Metal Cations on the Superprecipitation of Actomyosin from Rabbit Skeletal Muscle. Acta Academiae Mediciane Xuzhou, 1988; 8: 3438. 2. Lai, M.X., Gu, H.B., Zhao, A., and Xie, K.P. Isotope-traced Observing of Distribution and Living-period of transplantation Fetal Liver Cells. Chinese Journal of Pathophysiology, 1991; 7(5): 469. 3. Lai, M.X., Gu, H.B., Zhao, A., and Xie, K.P. The Influence of Fetal Liver Cell
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Transplantation on the Survival Rates of HIS Mice. Academic Journal of Guangdong Medical & Pharamceutical College, 1991; 7(2): 1-3. 4. Zhao, A. and Gu, H.B. Effects of Cadmium and Lead Ion on Conformation of Troponin C and Activity of Actomyosin ATPase from Rabbit Skeletal Muscles. Academic Journal of Guangdong College of Pharmacy, 1995; 11(4): 216-219. 5. Lin, Y.Z., Zhao, A., Chen, G.F., Chen, W.Q., Huang, Q.S., Luo, L.W., Li, H.Z., and Lai, M.X. Preparation and Characterization of Hepatitis B Virus-specific Transfer Factor. Academic Journal of Guangdong College of Pharmacy, 1995; 11(4): 240-243. 6. Gu, H.B., Zhao, A., and Liu, Y. Study on the Correlation between RBC-SOD Activity and RBC Immunoadherence Ability in Patients with Hepatitis B. Academic Journal of Guangdong College of Pharmacy, 1995; 11(4): 250-252. 7. Zhao, A., Xu, L., and Ma, J.C. Establishment and Application of Special Method for Detecting Hepatitis C Virus RNA. Academic Journal of Guangdong College of Pharmacy, 1996; 12(1): 10-13. 8. Zhao, A., Xu, L. and Ma, J.C. Cloning and Expression of Human Fibroblast Growth Factor cDNA in Escherichia Coli. Chinese Journal of Biochemical Pharmaceutic, 1996; 17(3): 93-96. 9. Feng, R.P., Hu, X.Q., and Zhao, A. Biological Activities and Clinical Application of Hepatic Stimulator Substance Prepared from Neonatal Liver of Different Species. Academic Journal of Guangdong College of Pharmacy, 1997; 13(2): 100-102. 10. Chen, W.Q., Zhao, A., and Chen, J.S. Autotransplantation of Hepatocytes into Spleen in cirrhosis Rats. Academic Journal of Guangdong College of Pharmacy, 1997; 13(4): 186-189. 11. Zhou, X., Zhao, A., Goping, G., and Hirszel, P. Gliotoxin-induced Cytotoxicity Proceeds via Apoptosis and is Mediated by Caspases and Reactive Oxygen Species in LLC-PK1 Cells. Toxicology Sciences, 2000; 54: 194-202. 12. Zhou, X., Jiang, G., Zhao, A., Bondeva, T., Hirszel, P., and Balla, T. Inhibition of Na, KATPase Activates PI3 Kinase and Inhibits Apoptosis in LLC-PK1 Cells. Biochemical Biophysical Research Communications, 2001; 285: 46-51. 13. Zhao A, Wu ZQ, Pollack M, Rollwagen FM, Hirszel P, and Zhou X. Disulfiram Inhibits TNF--induced Cell Death. Cytokine, 2000; 12(9): 1356-1367. 14. Zhao A, Bossone C, Piñeiro-Carrero V, and Shea-Donohue T. Colitis-induced Alterations in Adrenergic Control of Circular Smooth Muscle in Vitro in Rats. Journal of Pharmacology and Experimental Therapeutics 2001; 299(2): 768-774. 15. Zhao A, McDermott J, Urban JF, Gause WC, Madden KB, Au Yeung C, Morris SB, Finkelman FD, and Shea-Donohue T. Dependence of IL4, IL-13 and Nematode –Induced Alterations in Murine Small Intestinal Smooth Muscle Contractility on Stat6 and Enteric Nerves. Journal of Immunology, 2003, 171: 948-954. 16. Zhao A and Shea-Donohue T. Protease-Activated Receptor-2 Agonists Induce Contraction of Murine Small Intestine through Neurokinin Receptors. Am J Physiol Gastrointest Liver Physiol, 2003, 285: G696-G703. 17. Swiecki C, Stojadinovic A, Anderson J, Zhao A, Dawson H, and Shea-Donohue T. Effect of Hyperglycemia and Nitric Oxide Synthase Inhibition on Heat Tolerance and Induction of Heat Shock Protein 72 kDa in vivo. Am. Surg, 2003, 69(7): 587-592. 18. Madden KB, Au Yeung C, Zhao A, Gause WC, Finkelman FD, Katona IM, Urban JF, and Shea-Donohue T. Enteric Nematodes Induces Stereotypic STAT6-Dependent Alterations in Intestinal Epithelial Cell Function. Journal of Immunology, 2004 172(9): 5616-5621. 19. Dawson HD, Beshah E, Nishi S, Solano-Aguilar G, Zhao A, Madden K, Dubey JP, SheaDonohue T, Lunney JK, Urban JF Jr. Localized multi-gene expression patterns support an
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evolving Th1/Th2-like paradigm in response to infection with Toxoplasma gondii and Ascaris suum. Infection and Immunity, 2005, 73: 1116-1128. 20. Au Yeung K, Smith A, Zhao A, Madden KB, Elfrey J, Sullivan C, Levander O, Urban JF, and Shea-Donohue T. Impact of vitamin E or selenium deficiency on helminth-induced alterations in murine intestinal function. J. Exp. Parasitology, 2005, 109: 201-208. 21. Smith A, Madden KB, Au Yeung K, Zhao A, Elfrey J, Finkelman FD, Levander O, SheaDonohue T, Urban JF Jr. Effect of selenium and/or vitamin E deficiencies on Heligmosomoides polygyrus infections in mice. J. Nutrition, 2005, 135: 830-836. 22. Zhao A, Morimoto A, Dawson H, Elfrey J, Madden KB, Gause WC, Min B, Finkelman FD, Urban JF, Shea-Donohue T. Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection. Journal of Immunology, 2005, 175(4): 2563-2639. 23. Morimoto M, Morimoto M, Zhao A, Madden KB, Dawson H, Finkelman FD, Mentink-Kane M, Urban JF, Wynn T, Shea-Donohue T. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology, 2006, 176(1): 491-495. 24. Zhao A, Urban JF Jr., Morimoto M, Elfrey JE, Madden KB, Finkelman FD, Shea-Donohue T. Up-regulation of 5-HT2A Receptor Contributes to Nematode Infection-Induced Hypercontractility of Murine Intestinal Smooth Muscle. Gastroenterology, 2006, 131(2): 568-578. 25. Li E, Zhao A, Shea-Donohue T, Singer SM. Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Infection & Immunity, 2007, 75(9): 4514-4518. 26. Scanlan BJ, Tuft B, Elfrey JE, Smith A, Zhao A, Morimoto M, Chmielinska JJ, Tejero-Taldo MI, Mak IuT, Weglicki WB, Shea-Donohue T. Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function. Mol Cell Biochem. 2007, 306(1-2):59-69. 27. Shea-Donohue T, Thomas KE, Cody MJ, Zhao A, DeTolla LJ, Kopydlowski KM, Fukata M, Lira SA, and Vogel SN. Mice deficient in the CXCR2 ligand CXCL1 (KC/GRO-Îą) exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis. Innate Immunity, 2008, 14(2): 117-124. 28. Zhao A, Urban JF, Anthony AM, Sun R, Stiltz J, van Rooijen N, Wynn T, Gause WC, and Shea-Donohue T. Th2 cytokine-Induced Alterations in Intestinal Smooth Muscle Function are Dependent on Alternatively Activated Macrophages. Gastroenterology, 2008, 135(1): 217-225. 29. Sutton TL, Zhao A, Madden KB, Elfrey JE, Tuft BA, Sullivan CA, Urban, JF, and SheaDonohue T. Anti-inflammatory Mechanisms of Enteric Heligmosomoides polygyrus Infection on TNBS-Induced Colitis in a Murine Model. Infection & Immunity, 2008, 76(10): 4772-82. 30. Shea-Donohue T, Zhao A, Immune Regulation of Gut Function-The Role of T Helper 2 Cytokines and their Receptors. US Gastroenterology & Hepatology Review. 2008, 4(2):7376. 31. Morimoto M, Zhao A, Sun R, Stiltz J, Madden KB, Mentink-Kane M, Ramalingam T, Wynn TA, Urban JF Jr, Shea-Donohue T. IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J Immunol. 2009, 83(3):19341939. 32. Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, and Fasano A. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A. 2009, 106(39):16799-16804.
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33. Buzza MS, Netzel-Arnett S, Shea-Donohue T, Zhao A, Lin CY, List K, Szabo R, Fasano A, Bugge TH, and Antalis TM. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A. 2010, 107(9): 4200-4205. 34. Shea-Donohue T, Urban JF, Notari L, and Zhao A. Immune regulation of epithelial cell function: Implications for GI pathologies. International Dairy Journal. 2010, 20(4): 248-252. 35. Shea-Donohue T, Fasano A, Smith A, and Zhao A. Enteric pathogens and gut function: role of cytokines and STATs. Gut Microboes, 2010, 1 (5): 316-324. 36. Shea-Donohue T, Notari L, Stiltz J, Sun R, Madden KB, Urban JF, and Zhao A. Role of enteric nerves in the immune regulation of protease activated receptor-2 expression and function. Neurogastroenterology and Motility. 2010, 22(10): 1138-e291. 37. Shea-Donohue T, Stiltz J, Zhao A, and Notari L. Mast Cells. Curr Gastroenterol Rep. 2010, 12(5): 349-357. 38. Zhao A, Urban JF, Sun R, Stiltz J, Morimoto M, Notari L, Madden KB, Yang Z, Grinchuk V, Ramalingam TR, Wynn TA, and Shea-Donohue T. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol, 2010, 185(11): 6921-6929. 39. Zhonghan Yang, Viktoriya Grinchuk, Siu Po Ip, Chun-Tao Che, Harry H. S. Fong, Lixing Lao, Justin C. Wu, Joseph J. Sung, Brian Berman, Terez Shea-Donohue, and Aiping Zhao. Anti-inflammatory activities of a Chinese herbal formula IBS-20 in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine, 2012: 491496. 40. Terez Shea-Donohue, Luigi Notari, Rex Sun, and Aiping Zhao. Mechanisms of smooth muscle responses to inflammation. Neurogastroenterology and Motility. 2012, 24 (9):802811. 41. Zhonghan Yang, Viktoriya Grinchuk, Joseph F. Urban Jr, Jennifer Bohl, Rex Sun, Luigi Notari, Shu Yan, Thirumalai Ramalingam, Achsah D. Keegan, Thomas A. Wynn, Terez Shea-Donohue, and Aiping Zhao. Novel Role of Macrophages as IL-25/IL-33-Responsive Cells in the Induction of Type 2 Immunity. PLOS One. 2013, 8(3):e59441. 42. Aiping Zhao, Zhonghan Yang, Rex Sun, Viktoriya Grinchuk, Ian E Anglin, Sarah NetzelArnett, Luigi Notari, Jennifer a Bohl, Kathleen B madden, Joseph F. Urban Jr, Toni M Antalis, and Terez Shea-Donohue. SerpinB2 is Indispensable to Th2 Immunity against Enteric Nematode Infection. J. Immunol. 2013, 190(11): 5779-5787. 43. Zhonghan Yang, Viktoriya Grinchuk, Allen Smith, Bolin Qin, Jennifer Bohl, Rex Sun, Luigi Notari, Zhongyan Zhang, Hiromi Sesaki, Joseph F. Urban Jr, Terez Shea-Donohue, and Aiping Zhao. Enteric Nematode Infection-induced Immunotherapy against Obesity and the Associated Metabolic Syndrome. Infection and Immunity. 2013, 81(6):1905-1914. 44. Zhonghan Yang. Rex Sun, Viktoriya Grinchuk, Joan Antoni Fernandez Blanco, Luigi Notari, Jennifer A. Bohl, Leon P McLean, Thirumalai R. Ramalingam, Thomas A. Wynn, Joseph F. Urban Jr., Stefanie N. Vogel, Terez Shea-Donohue, and Aiping Zhao. IL-33-induced Alterations in Murine Intestinal Function and Cytokine Responses Are MyD88-, STAT6-, and IL-13-dependent. Am J Physiol Gastrointest Liver Physiol, 2013, 304(4):G381-389. 45. Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN. Dissociation of Endotoxin Tolerance and Differentiation of Alternatively Activated Macrophages. J. Immunol. 2013 190(9): 4763-4772. 46. Alaish SM, Smith AD, Timmons J, Greenspon J, Eyvazzadeh D, Murphy E, Shea-Donahue T, Cirimotich S, Mongodin E, Zhao A, Fasano A, Nataro JP, Cross A. Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host. Gut Microbes. 2013, 4(4):292-305.
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47. Alaish SM, Timmons J, Smith AD, Buzza MS, Murphy E, Zhao A, Sun Y, Turner DJ, SheaDonahue T, Antalis TM, Cross A, and Dorsey SG. Candidate genes for limiting cholestatic intestinal injury identified by gene expression profiling. Physiol Rep, 2013, Sep; [Epub ahead of publication] Book and Book Chapters Zhao, A.
Chapter 3: The Molecular Mechanism of cAMP-Cyclic AMP-dependent Protein Kinase. Page 23-31 Chapter 6: Cyclic Nucleotide Phosphodiesterase (CN-PDE). Page 44-50. Chapter 11: Calmodulin and Calmodulin-dependent Protein Kinase. Page 90-106. Chapter 18: Cellular Signal Transduction and Neuronal Function. Page 193-216. In: Cellular Signal Transduction System-Basic and Clinic Medicine. Editor: Lin, XG, et al Associate Editor: Zhao, A. et al Tianjin: Tianjin Science Press. 1996
Abstracts (peer-reviewed and published, since 2009) 1. A Zhao, A Smith, R Sun, J Stiltz, KB Madden, JF Urban Jr, T Shea-Donohue. Involvement of Gut Microbiota in Host Immune Response to Enteric Nematode Infection in Mice. Gastroenterology, 2009, 136(5): A-718. 2. KB Madden, DC Riera, A Zhao, J Stiltz, IM Katona, JF Urban Jr, T Shea-Donohue. Enteric nematode infection induces a “Lean� epithelial cell phenotype through differential regulation of glucose transporter expression. Gastroenterology, 2009, 136(5): A-95. 3. R Sun, A Zhao, J Stiltz, KB Madden, JF Urban Jr, TA Wynn, T Shea-Donohue. Type-2 IL4 receptor (IL-4r) plays a pivotal role in regulating the hypercontractile smooth muscle response to nematode infection. Gastroenterology, 2009, 136(5): A-719. 4. S Netzel-Arnett, T Shea-Donohue, MS Buzza, L Notari, A Zhao, R Sun, A Fasano, T Antalis. Protective role for matriptase during DSS-colitis. Gastroenterology, 2009, 136(5): A-557. 5. MS Buzza, S Netzel-Arnett, T Shea-Donohue, A Zhao, R Sun, A Fasano, T Antalis. Matriptase mediates epithelial barrier formation in the intestine. Gastroenterology, 2009, 136(5): A-412. 6. J Stiltz, S Netzel-Arnett, L Notari, T Antalis, JF Urban, T Shea-Donohue, A Zhao. Activation of host proteolytic pathways by nematode generated serine proteases is a stereotypic mechanism of molecular mimicry. Gastroenterology, 2009, 136(5): A-12. 7. J Shiu, QM Nhu, A Zhao, JF Urban, S Vogel, T Shea-Donohue. Interaction between alternatively activated macrophages and gut peptides in nematode infection. Gastroenterology, 2009, 136(5): A-719. 8. A Zhao, JF Urban Jr, R Sun, J Stiltz, M Motoko, L Notari, KB Madden, V Grinchuk, TR Ramalingam, TA Wynn, T Shea-Donohue. Critical role of epithelial cell-derived IL-25 in nematode-infection-induced changes in intestinal function in mice. Gastroenterology, 2010, 138(5): S-36. 9. R Sun, J Devito, J Stiltz, TA Wynn, KB Madden, JF Urban Jr, A Zhao, T Shea-Donohue. Mechanisms involved in the immune regulation of intestinal permeability. Gastroenterology, 2010, 138(5): S-621.
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10. J DeVito, L Notari, A Zhao, R Sun, J Stiltz, A Smith, CA Sullivan, T Shea-Donohue. Rethinking the role of IL-13 in chronic 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis induced fibrosis. Gastroenterology, 2010, 138(5): S-265. 11. L Notari, A Zhao, J Stiltz, S Yan, JN Rao, JF Urban Jr, T Shea-Donohue. Enteric nematodes regulate host proteolytic pathway on immune cells: influence on host immune response. Gastroenterology, 2010, 138(5): S-575. 12. J Stiltz, L Notari, A Zhao, JF Urban Jr, R Sun, T Shea-Donohue. Multiple roles for protease activated receptor-2 (PAR2) activation in the promotion of the TH2 responses. Gastroenterology, 2010, 138(5): S-574. 13. Zhonghan Yang, Viktoriya Grinchuk, Joseph F Urban, Jennifer A Stiltz, Rex Sun, Luigi Notari, Shu Yan, Thirumalai R Ramalingam, Thomas A Wynn, Terez Shea-Donohue, Aiping Zhao. Novel Role of Macrophage in the Induction of Th2 Immunity. Gastroenterology, 2011, 140(5): S-129. 14. Zhonghan Yang, Viktoriya Grinchuk, Terez Shea-Donohue, Chun-Tao Che, Lixing Lao, Justin C. Wu, Joseph J. Sung, Brian Berman, Aiping Zhao. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vivo and In Vitro. Gastroenterology, 2011, 140(5): S515. 15. Viktoriya Grinchuk, Zhonghan Yang, Allen Smith, Bolin Qin, Jennifer A. Stiltz, Rex Sun, Luigi Notari, Shu Yan, Joseph F. Urban, Terez Shea-Donohue, Aiping Zhao. IL-25-Induced Immunotherapy against Obesity and the Associated Metabolic Syndrome. Gastroenterology, 2011, 140(5): S-44. 16. Luigi Notari, Shu Yan, Rex Sun, Viktoriya Grinchuk, Jennifer A. Stiltz, Aiping Zhao, Allen Smith, Terez Shea-Donohue. Role of Altered Intestinal Function in the Protective Effects of Nematode Infection Against the Development of Type 1 Diabetes (T1d) in Non Obese Diabetic (NOD) Mice. Gastroenterology, 2011, 140(5): S-369. 17. Sarah Netzel-Arnett, Marguerite S. Buzza, Terez Shea-Donohue, Aiping Zhao, Alessio Fasano, Toni M. Antalis. The Role of Matriptase, Urokinase-Type Plasminogen Activator, and SERPINE1 in Colitis Pathogenesis. Gastroenterology, 2011, 140(5): S-650. 18. Jennifer A. Stiltz, Luigi Notari, Rex Sun, Aiping Zhao, Sarah Netzel-Arnett, Toni M. Antalis, Joseph F. Urban, Terez Shea-Donohue. Protease Activated Receptor-2 (PAR2) Plays a Role in TH2-Mediated Protective Immunity in Response to Enteric Nematode Infection. Gastroenterology, 2011, 140(5): S-27. 19. Siew C. Ng, Kelvin K. Tsoi, Thomas Lam, Zhao-xiang Bian, Lixing Lao, Brian Berman, Aiping Zhao, Chun-Tao Che, Joseph J. Sung, Justin C. Wu. Complementary and Alternative Therapies for the Treatment of Inflammatory Bowel Disease: A Systematic Review of Human Studies. Gastroenterology, 2011, 140(5): S-209-210. 20. Leon McLean, Luigi Notari, Rex Sun, Jennifer A. Stiltz, Viktoriya Grinchuk, Shu Yan, Aiping Zhao, Jean-Pierre Raufman, Terez Shea-Donohue. Type 1 and Type 3 Muscarinic Receptors Modulate Intestinal Barrier Function. Gastroenterology, 2011, 140(5): S-474-475. 21. Zhonghan Yang, Viktoria Grinchuk, Allen Smith, Jenny Stiltz, Rex Sun, Luigi Notari, Shu Yan, Joseph F Urban, Terez Shea-Donohue, Aiping Zhao. Impaired Host Th2 Immunity against Nematode Infection in Mice with Diet-induced Obesity. Neurogastroenterology and Motility, 2011, 23(s1):44. 22. Sun, Rex Sun; Luigi Notari, Tim Vanuytsel, Jennifer Stiltz, Thomas Wynn, Joseph F Urban, Aiping Zhao, Terez Shea-Donohue. Rethinking the Role of Claudin-2 in IL-13-Mediated Changes in Intestinal Permeability. Neurogastroenterology and Motility, 2011, 23(s1):43.
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23. Tim Vanuytsel, Luigi Notari, Shu Yan, Aiping Zhao, Jennifer A. Bohl, Leon McLean, Rex Sun, Joseph F. Urban, Allen Smith, Jan F. Tack, Terez Shea-Donohue. Immune Regulation of the Intestinal Progenitor Cell Microenvironment. Gastroenterology. 2012, 142, S-597 24. Jennifer A. Bohl, Joseph F. Urban, Luigi Notari, Rex Sun, Aiping Zhao, Shu Yan, Viktoriya Grinchuk, Tim Vanuytsel, Leon McLean, Zhonghan Yang, Terez Shea-Donohue. Nematode Generated Protease Activation of PAR2 Plays a Key Role in the TH2 Protective Immune Response. Gastroenterology. 2012, 142, S-596 25. Leon McLean, Viktoriya Grinchuk, Aiping Zhao, Rex Sun, Jean-Pierre Raufman, Terez Shea-Donohue. Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of TH1 Cytokines. Gastroenterology. 2012, 142, S-140 26. Zhenzhong Wang, Zhonghan Yang, Viktoriya Grinchuk, Kejin Zhu, Terez Shea-Donohue, Aiping Zhao, Wei Xiao. Anti-Inflammatory and Intestinal Function-Modulating Activities of a Traditional Chinese Herbal Formula Houxiang Zhengqi. Gastroenterology. 2012, 142, S726 27. Zhonghan Yang, Viktoriya Grinchuk, Joseph F Urban, Jennifer A. Bohl, Rex Sun, Luigi Notari, Thirumalai R. Ramalingam, Thomas A. Wynn, Terez Shea-Donohue, Aiping Zhao. Macrophages are the IL-33-Responsive Cells Pivotal to the Induction of TH2 Immunity. Gastroenterology. 2012, 142, S-126 28. Shu Yan, Luigi Notari, Tim Vanuytsel, Aiping Zhao, Alexander Bennett, Julie Tudor, Gregory L. Tudor, Catherine Booth, Ann M. Farese, Thomas J. MacVittie, Terez SheaDonohue. Possible Role of Barrier Dysfunction and Inflammation in the Alteration of the Stem Cell Microenvironment. Gastroenterology. 2012, 142, S-333 29. Leon Mclean, Luigi Notari, Rex Sun, JA Bohl, S Yan, V Grinchuk, Aiping Zhao, et al. Type 3 muscarinic receptor deficiency is associated with impaired paracellular permeability and activation of myosin light chain 2. Gastroenterology. 2013, 144, S-123 30. Anjiang Wang, Y Li, Z Yang, V Grinchuk, A Smith, B Qin, JA Bohl, R Sun, L Notari, JF Urban, T Shea-Donohue, and Aiping Zhao. Parasitic nematode-induced modulation of body weight and the associated metabolic dysfunction in mouse model of obesity. Gastroenterology. 2013, 144, S-713 Invited Presentations 04/02/2001 “Colitis-Induced Alterations in Adrenergic Control of Smooth Muscle in Rats”, Walter Reed Army Institute of Research, Silver Spring, Maryland, invited by Dr. George Tsokos. 02/03/2003
“Immune Regulation of Protease-Activated Receptors in the Gut”, Uniformed Services University of the Health Sciences, Bethesda, Maryland, invited by Dr. Robert Goldstein.
03/20/2005
“Immune Regulation of 5-HT2A Receptors in Intestine during Helminth Infection”, Mucosal Biology Research Center, University of Maryland, Baltimore, Maryland, invited by Dr. Fasano.
06/16/2007
“Alternately-activated macrophages and arginase I play pivotal role in nematode infection-induced alternation in intestinal smooth muscle function”, Mucosal Biology Research Center, University of Maryland, Baltimore, Maryland, invited by Dr. Alessio Fasano.
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09/10/2007
“Immune regulation of gut function and inflammation”,Division of Gastroenterology, Zhujiang Hospital, Nanfang Medical University, Guangzhou, China, invited by Dr. Hua Mao.
04/17/2009
“Impaired host defense response against nematode infection in mice with PAI-2 deficiency”, Protease Interest Group, University of Maryland, Baltimore, Maryland, invited by Dr. Sarah Netzel-Arnett.
06/02/2009
“IL-25 regulation of gut function and inflammation”, Department of Pharmacology, University of Illinois in Chicago, Chicago, Illinois, invited by Dr. Guochang Hu.
10/30/2009
“Critical role of epithelial cell-derived IL-25 in nematode infection-induced alterations in intestinal function”. IRG, University of Maryland, Baltimore, Maryland, invited by Dr. Ishwa Singh.
09/15/2010
“Immune Regulation of Gut Smooth Muscle and Epithelial Cell Function”, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, invited by Dr. John R. Grider.
09/23/2010
“Epithelial Cells Orchestrate Host Immunity against Enteric Nematode Infection”, BARC, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland, invited by Dr. Joseph Urban.
02/17/2011
“Anti-inflammatory Activities of IBS-20”, International Center for Research on Complementary and Alternative Medicine Symposium, The Chinese University of Hong Kong, Hong Kong, invited by Dr. JJ Sung.
02/18/2011
“Animal Models of Inflammatory Bowel Disease”, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, invited by Dr. JC Wu.
02/23/2011
“Epithelial Cell-derived Cytokines Orchestrate Host Immunity against Enteric Nematode Infection”, Institute of Digestive Disease, The 1st affiliated Hospital, Nanchang University School of Medicine, Nanchang, invited by Dr. Nonghua Lu.
03/01/2011
“Mechanistic Investigation of Chinese Herbal Medicine: Past, Present, and Future”, Kanion Pharmaceuticals, Lianyungang, invited by Dr. Wei Xiao.
03/03/2011
“Interleukin-25 Regulates Intestinal Immunity and Inflammation”, Xuzhou Medical University, Xuzhou, invited by Dr. Gongjian Liu.
04/08/2011
“ Novel Role of Macrophage in the Induction of Th2 Immunity”, Uniformed Services University of the Health Sciences, Bethesda, Maryland, invited by Drs. David Scott and Xiaoming Zhou.
05/09/2011
“Epithelial-derived Cytokine and Th2 Immunity”, University of Illinois in Chicago, Chicago, Illinois, invited by Richard Minshall.
06/05/2011
“Macrophages Play Pivotal Role in IL-25/IL-33-mediated Th2 Host Protective
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Immunity against Enteric nematode Infection”, NIAID, NIH, Bethesda, Maryland, invited by Dr. Tom Wynn. 09/19/2011
“Epithelial-derived cytokine regulation of gut function and inflammation”, University of Michigan Medical School, Ann Arbor, Michigan, invited by Drs. Chung Owyang and Shaoyong Yu.
11/22/2011
“Immunotherapy against Obesity and Metabolic Diseases”, The 2011 SCBA DCBaltimore Chapter Scientific Symposium on Bioscience, Rockville, Maryland, invited by the Organizing Committee.
01/11/2012
“Helminth-induced Immunotherapy against Obesity: Role of Cytokines and Innate Immune Cells”. The Johns Hopkins University School of Medicine, Baltimore, Maryland, invited by Dr. Xuheng Li.
06/26//2012
“Immunotherapy against Obesity and the Associated Metabolic Dysfunction”. Sun Yat-Sen University School of Medicine, Guangzhou, China, invited by Dr. Guoquan Gao.
06/27//2012
“Immunotherapy against Obesity and the Associated Metabolic Dysfunction”. Guangdong Pharmaceutical University, Guangzhou, China, invited by Dr. HongYang.
07/13/2012
“Innovating Clinical Research”. City Hospital of Yichun, Jiangxi, China, invited by Dr. Huijing Fan.
12/12/2012
“Type 2 Cytokine Modulation of Body Weight and Metabolic Dysfunction”, NIAAA, NIH, Bethesda, Maryland, invited by Dr. Bin Gao.
Patents 1. Aiping Zhao, Terez Shea-Donohue. “Use of IL-25 as a therapeutic agent against obesity and the associated metabolic diseases”, US Provisional Patent Application Number: 61/461,122, filed on 01/13/2011 2. Aiping Zhao, Wei Xiao, Zhenzhong Wang, Kejin Zhu. “Anti-inflammatory and Intestinal Funciton-Modulating Activities of an Herbal Formalation”, US Provisional Patent Application Number: 61/649,287, filed on 05/23/2012