Molecular Pathology
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Molecular Pathology
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The nascent chain (run-on) assay allows measurement of the rate of transcription of a given gene!
Molecular Biology Principles
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Molecular Pathology
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Molecular Pathology
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I: pre-rRNA! II: mRNA! III: tRNAs, 5S rRNA, ! small stable RNAs!
Repeat = Tyr-Ser-Pro-Thr-Ser-Pro-Ser!
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Molecular Pathology
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Alternative promoters in eukaryotes include initiators and CpG islands!
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Molecular Pathology
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Identification of the SV40 enhancer region!
Molecular Biology Principles
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Molecular Pathology
Molecular Biology Principles
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Molecular Pathology
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Molecular Pathology
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Molecular Pathology
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Molecular Pathology
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Molecular Pathology
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Eukaryotic transcription is regulated by repressors as well as activators! Repressor-binding sites can be identified and repressors purified by the same techniques used for activators! Many eukaryotic repressors have two domains: a DNAbinding domain and a repressor domain!
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Molecular Pathology
Molecular Biology Principles
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Molecular Pathology
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Silent genes in mating-type control in yeast!
Molecular Biology Principles
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Molecular Pathology
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Binding sites for activators that control transcription of the mouse TTR gene!
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Molecular Pathology
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Molecular Pathology
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Molecular Pathology
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Model of IFN-mediated gene activation by phosphorylation and dimerization of Stat1!
Molecular Biology Principles
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Molecular Pathology
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Copyright (c) by W. H. Freeman and Company
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