Probiotics for CKD, mechanism of action, uses and more
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, The Enteric uremic toxin reducer!
The gut has been identified as a Potential source of inflammation in CKD patients , Probiotics have promising effects by altering production and absorption of uremic toxins and decreasing inflammation. helps in
Rapid Reduction of Uremic Toxins in CKD patients Delay the Progression of CKD from stage 3-4 to End Stage Renal Disease
, The Enteric uremic toxin reducer!
capsule has
Probiotics NLT 45 Billion cells of a blend of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, Bacillus coagulans.
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Formulated by the house of Probiotic originator of 50 + yrs experience in manufacturing a variety of proprietary Probiotic products which are stable during shelf life, unaffected during Gastric transit and reach intact the label claim microbial count for colonization.
a blend of 4 Probiotics and each has a significant function as shown below
Streptococcus thermophilus
High urea utilising microbe
Bacillus coagulans
After the permeability of gut for passing of toxins
Bifidobacterium longum
Helps in removal of putrefactive bacteria
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Lactobacillus acidophilus
Removes p-Cresol and indoxyl toxins
Does help like a dialyzer in CKD patients ?
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Enteric
Superiority over similar other products
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Toxin Reduction Technology uses probiotics to transform GUT into Dialyser
USPS CF 90 AUX 90 Additional Strain Bacillus coagulans alters the permeability of gut for passing toxins Absent Absent Storage No Cold Storage Strictly below 18 c Strictly below 18 c Probiotic History Brand from House of Probiotics originator of 50 + yrs experience NA NA
CFU: Colony Forming Units
NLT 45 Billion CFU reaches intact the target site & multiplies for the next 10 – 12 hrs with twice daily dose helps to lower circulating toxins in CKD patients
LOBUN range available as
Once a day dose of 90 Billion may not adequate in lowering toxin load round the clock as microbial count comes down- after some hours
Once a day dose of 90 Billion with Prebiotic fructooligosaccharides(FOS). Probiotics colonization does not need any Prebiotic support. Does not adequate in lowering toxin load round the clock as microbial count declines after some hours.
Each Capsule has Streptococcus thermophilus, Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus to be taken twice daily after meals
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AUX
USPS CF 90
90
Each Capsule has Streptococcus thermophilus, Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus to be taken thrice daily after meals
Outcomes
As evident from published clinical study of 45B CFU of Multispecies Probiotic
2 2
6 months clinical study in CKD 3 & 4 stage
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Urea hydrolysis in Large Intestine
hydrolysis
33% more Urea in 24 Hours
Acts at Ph > 7 and more potential than CF 90 strain
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Benefits of therapy in CKD patients
Lowers Urea, Uric acid and Creatinine
Reduces systemic circulation of DMA, NDMA, p-Cresol, Indoles and Phosphate
Improves GFR & QOL
DMA : Dimethyl amine
NDMA : Nitroso dimethyl amine
GFR : Glomerular Filtration Rate
QOL : Quality of Life
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References:
1. Lau WL, Kalantar-Zadeh K, Vaziri ND. The Gut as a Source of Inflammation in Chronic Kidney Disease. Nephron. 2015;130(2):92-8.
2. Adv Ther 2010 Sep;27(9):634-47.
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