Lobun Forte: Probiotics for CKD

Probiotics for CKD, mechanism of action, uses and more medicaldialogues.in/partner/jbcpl/lobun-forte

, The Enteric uremic toxin reducer!

The gut has been identified as a Potential source of inflammation in CKD patients1, Probiotics have promising effects by altering production and absorption of uremic toxins and decreasing inflammation. helps in Rapid Reduction of Uremic Toxins in CKD patients Delay the Progression of CKD from stage 3-4 to End Stage Renal Disease

, The Enteric uremic toxin reducer!

capsule has Probiotics NLT 45 Billion cells of a blend of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, Bacillus coagulans.

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Formulated by the house of Probiotic originator of 50 + yrs experience in manufacturing a variety of proprietary Probiotic products which are stable during shelf life, unaffected during Gastric transit and reach intact the label claim microbial count for colonization.

a blend of 4 Probiotics and each has a significant function as shown below Streptococcus thermophilus High urea utilising microbe Bacillus coagulans After the permeability of gut for passing of toxins Bifidobacterium longum Helps in removal of putrefactive bacteria

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Lactobacillus acidophilus Removes p-Cresol and indoxyl toxins

Does help like a dialyzer in CKD patients ?

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Enteric Toxin Reduction Technology uses probiotics to transform GUT into Dialyser

Superiority over similar other products

USPS

CF 90

AUX 90

Additional Strain

Bacillus coagulans alters the permeability of gut for passing toxins

Absent

Absent

Storage

No Cold Storage

Strictly below 18 c

Strictly below 18 c

Probiotic History

Brand from House of Probiotics originator of 50 + yrs experience

NA

NA

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USPS CFU: Colony Forming Units

NLT 45 Billion CFU reaches intact the target site & multiplies for the next 10 – 12 hrs with twice daily dose helps to lower circulating toxins in CKD patients

CF 90

AUX 90

Once a day dose of 90 Billion may not adequate in lowering toxin load round the clock as microbial count comes down- after some hours

Once a day dose of 90 Billion with Prebiotic fructooligosaccharides(FOS).

Probiotics colonization does not need any Prebiotic support. Does not adequate in lowering toxin load round the clock as microbial count declines after some hours.

LOBUN range available as

Each Capsule has Streptococcus thermophilus, Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus to be taken twice daily after meals

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Each Capsule has Streptococcus thermophilus, Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus to be taken thrice daily after meals

Outcomes As evident from published clinical study2 of 45B CFU of Multispecies Probiotic

6 months clinical study in CKD 3 & 4 stage2

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Urea hydrolysis in Large Intestine

hydrolysis 33% more Urea in 24 Hours

Acts at Ph > 7 and more potential than CF 90 strain

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Benefits of therapy in CKD patients

Lowers Urea, Uric acid and Creatinine

Reduces systemic circulation of DMA, NDMA, p-Cresol, Indoles and Phosphate

Improves GFR & QOL

DMA : Dimethyl amine NDMA : Nitroso dimethyl amine GFR : Glomerular Filtration Rate QOL : Quality of Life 8/9

References: 1. Lau WL, Kalantar-Zadeh K, Vaziri ND. The Gut as a Source of Inflammation in Chronic Kidney Disease. Nephron. 2015;130(2):92-8.

2. Adv Ther 2010 Sep;27(9):634-47.

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