Normativa 41. Diagnóstico y tratamiento del derrame pleural

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cicos, guiados por TC o ecografía (D). Si no son eficaces, puede tratarse con la instilación de fibrinolíticos intrapleurales (B). Una alternativa, o si los fibrinolíticos no son eficaces, es la evacuación temprana de los coágulos mediante toracoscopia (C). – Si la toracoscopia no es eficaz o el hemotórax es crónico y produce atrapamiento pulmonar —fibrotórax— se procederá a la decorticación (D).

Glosario de siglas ADA: Adenosina desaminasa ANA: Anticuerpos antinucleares AR: Artritis reumatoide BP: Biopsia pleural DP: Derrame Pleural DPPN: Derrame pleural paraneumónico DPTB: Derrame pleural tuberculoso FR: Factor reumatoide ICC: Insuficiencia cardíaca congestiva IFNG: Interferón gamma IL: Interleucina LES: Lupus eritematoso sistémico LP: Líquido pleural NN: Neumonía nosocomial PCR: Reacción en cadena de la polimerasa QT: Quilotórax TC: Tomografía computarizada TB: Tuberculosis TNF: Factor de necrosis tumoral TVA: Toracoscopia videoasistida

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Bibliografía 1. Light RW, Lee YCG, editors. Textbook of pleural diseases. London: Arnold; 2003. 2. Villena V, López Encuentra E, García-Luján R, et al. Clinical implications of appearance of pleural fluid at thoracentesis. Chest. 2004; 125:156-9. 3. Cheng DS, Rodríguez RM, Rogers J, et al. Comparison of pleural fluid pH values obtained using blood gas machine, pH meter, and pH indicator strip. Chest. 1998;114:1368-72. 4. Jiménez-Castro D, Díaz G, Pérez-Rodríguez E, et al. Modification of pleural fluid pH by local anesthesia. Chest. 1999;116:399-402. 5. Heffner JE, Brown LK, Barbieri C, et al. Pleural fluid chemical analysis in parapneumonic effusions. A metanalysis. Am J Respir Crit Care Med. 1995;151:1700-8. 6. Rodríguez-Panadero F, López Mejías J. Low glucose and pH levels in malignant pleural effusions. Diagnostic significance and prognostic value in respect to pleurodesis. Am Rev Respir Dis. 1989;139:663-7. 7. Jiménez D, Pérez Rodríguez E, Díaz G, et al. Determining the optimal number of specimens to obtain with needle biopsy of the pleura. Respir Med. 2002;96:14-7. 8. Porcel JM, Vives M. Etiology and pleural fluid characteristics of large and massive effusions. Chest. 2003;124:978-83. 9. Ferrer J, Roldán J, Teixidor J, et al. Predictors of pleural malignancy in patients with pleural effusion undergoing thoracoscopy. Chest. 2005;127:1017-22. 10. Ferrer JS, Muñoz XG, Orriols RM, et al. Evolution of idiopathic pleural effusion: a prospective, long-term follow-up study. Chest. 1996; 109:1508-13. 11. Romero Candeira S, Hernández Blasco L, Romero Brufao S. Trasudados frente a exudados pleurales. Criterios discriminantes. Causas de trasudado pleural y aproximación diagnóstica. En: Pérez Rodríguez E, Villena Garrido MV, editores. Enfermedades de la pleura. Monografías Neumomadrid. Madrid: Ergon; 2003. p. 57-68. 12. Romero-Candeira S, Hernández L. The separation of transudates and exudates with particular reference to the protein gradient. Curr Opin Pulm Med. 2004;10:294-8. 13. Sahn SA. Management of complicated parapneumonic effusions. Am Rev Respir Dis. 1993;148:813-7. 14. Chen KY, Hsueh PR, Liaw YS, et al. A 10-year experience with bacteriology of acute thoracic empyema: emphasis on Klebsiella pneumoniae in patients with diabetes mellitus. Chest. 2000;117:1685-9. 15. Maskell NA, Davis CWH, Nunn AJ, et al. U.K. controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med. 2005; 352:865-74. 16. Davies CW, Kearney SE, Gleeson FV, et al. Predictors of outcome and long-term survival in patients with pleural infection. Am J Respir Crit Care Med. 1999;160:1682-7. 17. Maskell NA, Gleeson FV, Darby M, et al. Diagnostically significant variations in pleural fluid pH in loculated parapneumonic effusions. Chest. 2004;126:2022-4. 18. Heffner JE. Indications for draining a parapneumonic effusion: an evidence-based approach. Semin Respir Infect. 1999;14:48-58. 19. Colice GL, Curtis A, Deslauriers J, et al. Medical and surgical treatment of parapneumonic effusions: an evidence-based guideline. Chest. 2000;118:1158-71.

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