BIBLIOGRAFíA 1. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun. 1991(16); 181:852–7. 2. Schleich FN, Seidel L, Sele J, et al. Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma. Thorax. 2010; 65(12):1039–44. 3. Smith AD, Cowan JO, Brassett KP, et al. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med. 2005; 172:453–459. 4. Szefler SJ, Martin RJ, King TS, et al. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002; 109: 410–418. 5. Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011; 184(5):602–15. 6. Guía española para el manejo del asma (GEMA 2009). Disponible en: www. gemasma.com. 7. Pérez-de-Llano LA, Carballada F, Castro Añón O, et al. Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma. Eur Respir J. 2010; 35(6):1221–7. 8. Petsky HL, Cates CJ, Li A, Kynaston JA, et al. Tailored interventions based NO exhalednitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev. 2009; (4):CD006340. 9. McNicholl DM, Stevenson M, McGarvey LP, et al. The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma. Am J Respir Crit Care Med. 2012; 186(11):1102–8. 10. Fortuna AM, Feixas T, Casan P. Measurement of fraction of exhaled nitric oxide with the portable NIOX-MINO monitor in healthy adults]. Arch Bronconeumol. 2007; 43(3):176–9. 29