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41st Annual Meeting & Exposition of the Controlled Release Society

of Delivery Technology: Innovation to Commercialization ŠChoose Chicago

July 13–16, 2014 The Hilton Chicago Chicago, Illinois, U.S.A.

About the Society

Schedule-at-a-Glance ........................................ 4 Program Highlights ........................................... 6 CRS Innovation Sunday ................................... 14 Premeeting Workshops .................................. 15 Networking Opportunities ............................. 19 CRS Foundation .............................................. 21 Exposition and Sponsorship ........................... 22 Registration Information ................................. 23 Meeting & Hotel Information ......................... 26 Chicago: Hub of the Midwest and World Class Destination .............................. 27

The Controlled Release Society (CRS) is the premier international, multidisciplinary society dedicated to delivery science and technology. In the constantly and quickly expanding field of delivery science, keeping up with the latest scientific research and technological breakthroughs is crucial. CRS serves members from industry, academia, and government in more than 50 countries worldwide by providing innovative research, targeted networking, and career advancement. Join CRS to network and learn from scientific leaders, investors, and business development professionals who are focused on drug delivery as well as delivery applications in consumer and diversified products and animal health.


Table of Contents


Our Diversity Is Our Strength

Join us in Chicago for an expansive program designed to cover the discovery, development, and delivery continuum. The Controlled Release Society (CRS) is a unique professional association within the delivery science field. We are a diverse group, both in the work and research we do and in the broad way in which our work is utilized and applied in both pharmaceuticals (including preclinical sciences and animal health) and nonpharmaceuticals (including consumer and diversified products).

Ian Tucker

I invite you to join us as we work together to address some of the most pressing and challenging issues in delivery science and technology, including fundamental delivery research, development, regulatory science, and clinical translation. Advance your work and help shape the future of delivery science and technology: attend the 41st Annual Meeting & Exposition of the Controlled Release Society. Ian Tucker University of Otago, New Zealand President, Controlled Release Society

Program Team 2014 Annual Meeting Program Planning Committee

Chair: Ick Chan Kwon, KIST, Korea Deputy Chair: Justin Hanes, Johns Hopkins University, U.S.A.

Members: You Han Bae, University of Utah, U.S.A. Donald Barbieri, Patheon, U.S.A. Ben Boyd, Monash University, Australia Peter Cheifetz, Merial Limited, U.S.A. Samir Mitragotri, University of California, Santa Barbara, U.S.A. Ruth Schmid, SINTEF, Norway Hardik Shah, Alkermes Pharma Ireland Ltd., Ireland Ronald Smith, Merck, U.S.A. Geert Verreck, Janssen Pharmaceutica, Belgium Fanwen Zeng, Dow Chemical Company, U.S.A. 3

Schedule-at-a-Glance Saturday, July 12

Monday, July 14

07:00 – 15:00 07:00 – 17:00 08:00 – 17:00 08:00 – 17:00 08:00 – 17:00

07:00 – 08:00 07:00 – 17:30 07:00 – 18:00 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 17:30 09:30 – 17:30 10:30 – 12:00 11:30 – 13:30 12:00 – 13:30 13:30 – 14:45 15:00 – 16:30 16:30 – 17:30 17:30 – 18:30 21:00 – 22:30

CRS Registration Open Speaker Preparation Room Open Exhibit Set-up Premeeting Workshops Young Scientist Workshops

Sunday, July 13 07:00 – 17:30 07:30 – 18:00 08:00 – 12:00 08:00 – 12:00 08:00 – 14:00 09:00 – 12:30 11:30 – 12:30 12:30 – 14:00 13:00 – 15:10 14:00 – 15:30 15:30 – 17:30 17:30 – 19:30


Speaker Preparation Room Open CRS Registration Open Premeeting Workshops Young Scientist Workshop Exhibit and Poster Set-up Technology Forums First Timers’ Meeting Young Scientist Roundtable Soapbox Session Mentor/Protégé Meet and Greet Industry Roundtable Exposition Grand Opening & Welcome Reception

Get Up! Get Educated! Speaker Preparation Room Open CRS Registration Open CRS Opening Session Exposition Open – Meet with Exhibitors Poster Session 1 (authors present) Exposition Hall Open Poster Viewing Scientific Sessions Women in Science Luncheon Exposition Open Plenary Session Scientific Sessions Poster and Exposition Happy Hour PSAH Networking Get-Together Young Scientist Networking Event

Tuesday, July 15

Wednesday, July 16

07:00 – 08:00 07:00 – 16:00 07:00 – 17:30 07:00 – 17:30 08:00 – 09:30 09:30 – 10:30 09:30 – 10:30 09:30 – 16:00 10:30 – 12:00 12:00 – 13:30 12:00 – 16:00 13:30 – 15:00 15:00 – 16:00 16:00 – 17:00 16:00 – 17:30 16:00 – 18:00 18:30 – 22:00

07:30 – 12:00 08:00 – 09:30 09:45 – 11:00

Get Up! Get Educated! Poster Viewing CRS Registration Open Speaker Preparation Room Open Plenary Session Exposition Open – Meet with Exhibitors Poster Session 2 (authors present) Exposition Hall Open Scientific Sessions C&DP Luncheon Exposition Open – Meet with Exhibitors Scientific Sessions Poster Session 3 (authors present) Poster Take-down Roundtables and Focus Groups Exhibit Take-down CRS President’s Banquet

CRS Registration Open Scientific Sessions Plenary Session 5

Program Highlights Access the latest in delivery science and technology through a wide variety of learning opportunities, including CRS Innovation Sunday, featured plenary sessions, premeeting workshops, interactive roundtables, minisymposia, and more. You will have the chance to discover the latest findings in your area of delivery science, plus expand your knowledge of and apply technologies from other areas.

Exposition Grand Opening & Welcome Reception The official welcome to the CRS Annual Meeting and Exposition! Join your colleagues and exhibiting companies for an evening of appetizers and beverages, along with the chance to connect one-to-one with your fellow scientists and company representatives.

CRS Opening Session The opening session will feature a welcome by President Ian Tucker and the presentation of the 2014 Fellows awards, along with the Founders, CRS T. Nagai Postdoctoral Research Award and the Young Investigator Award. The session will conclude with a lively panel discussion organized by our College of Fellows.


Plenary Sessions Headlining this year’s program are plenary lectures from three industry leaders within the delivery science and technology field. These lectures offer a high-level look at technology and paths to bringing it to practical use. Monday, July 14 13:30 – 14:45 David Grainger

University distinguished professor and chair of the Department of Pharmaceutics and Pharmaceutical Chemistry and professor of bioengineering, University of Utah, U.S.A.

Taking Shape: Transitioning 3D Assays to Improve Drug Screening and Toxicity Predictions Many new 3D cell culture models seek to preserve in vivo-like organization within tissue-like or organoid constructs to elicit more relevant pharmacological toxicity and toxicity marker upregulation. These 3D cell culture models can yield better data quality with more accurate, tissue-specific information to significantly improve the technical output, predictive value, and translation between in vitro, animal, and clinical human studies. Further developments using 3D models that yield native extracellular matrix, relevant tissue architectures, and restoration of both chemical and mechanical tissue-like stimulation using bioreactors are critical for advancing drug screening.

Tuesday, July 15 08:00 – 09:30 Chad Mirkin

Director of the International Institute for Nanotechnology, Northwestern University, U.S.A.

Spherical Nucleic Acid (SNA) Nanostructures: Establishing a New Paradigm in Molecular Diagnostics and Intracellular Gene Regulation There are many challenges to delivering nucleic acids in an efficient, nontoxic, and non-immunogenic fashion. Because nucleic acids are negatively charged and prone to degradation, researchers have relied on transfection agents, which are often toxic and elicit severe immunogenicity. Spherical nucleic acids (SNA) (inorganic nanoparticle cores functionalized with a shell of densely organized, highly oriented nucleic acids) pose one possible solution to these problems in the context of both antisense and RNAi pathways. Methods to synthesize such structures and novel applications that take advantage of the properties unique to spherical and other forms of 3D nucleic acids will be described.

Wednesday, July 16 09:45 – 11:00 David Edwards

Professor of the Practice of Idea Translation, Harvard University, U.S.A.

Redesigning Nutrition Delivery The features of man-made delivery systems underlying the trillion-dollar food and beverage industry often contrast poorly with those of natural systems. Natural foods involve little or no environmental waste, encourage portion control, and efficiently deliver functional nutrition in mobile circumstances. These and other qualities, having ensured the sustainable nourishment of animals and humans for many thousands of years, can be critically absent in today’s food industry. This talk highlights the current revolution in the redesign of nutrition delivery aimed at meeting the health and environmental challenges of the 21st century. It especially highlights recent breakthroughs from our labs in the fields of aerosol foods and edible and biodegradable food packaging. 7

Invited Speakers The 41st Annual Meeting & Exposition of the Controlled Release Society is pleased to announce the following invited speakers. Topic descriptions can be found on the CRS website. Speakers are subject to change.

Scientific Sessions Bioactive technical sessions are focused on various aspects within the extensive scope of controlled release and delivery, including nanoparticles, RNA and DNA delivery, cell-based delivery, transdermal delivery, overcoming biological barriers, and drug delivery to the eye, lung, and brain. The sessions are rounded out with two Preclinical Sciences & Animal Health (PSAH) sessions on formulation development and predictive animal models, and four Consumer & Diversified Products (C&DP) sessions covering process engineering, methods, and applications in consumer products, food, feed, and beverages. Advances in Drug Delivery to the Eye Peter Humphries, Trinity College Dublin, Ireland Advances in Drug Delivery to the Lung Paul Young, University of Sydney, Australia Advances in Process Engineering窶年ew Methods for the Production of Particles, Capsules, and Coatings Abhijit Gokhale, Patheon, U.S.A. Advances in RNA and DNA Delivery Yoshiki Katayama, Kyushu University, Japan


Breakthrough Technologies Chris Bettinger, Carnegie-Mellon University, U.S.A.

Nanoparticles in Tumor Treatment Youqing Shen, Zhejiang University, China

Cells as Delivery Vehicles Maciej Lesniak, University of Chicago, U.S.A.

Novel Developments in Formulation, Analytical Chemistry, and Processing in Animal Health and Preclinical Sciences Susan Cady, Merial Ltd., U.S.A.

Controlled Release of Actives in Consumer Products Nilesh Shah, Dow Chemical, U.S.A. Controlled Release Applications in Food, Feed, and Beverages Erich Windhab, ETH ZĂźrich, Switzerland Evaluation and Characterization of Controlled Release Products and Production Processes Lew Brown, Fluid Imaging Technologies, U.S.A. Innovations in Micro- and Nano-Based Delivery Adah Almutairi, University of California, San Diego, U.S.A. Innovations in Oral Drug Delivery Youngro Byun, Seoul National University, Korea Intracellular Delivery of Nucleic Acids and Proteins Patrick Stayton, University of Washington, U.S.A.

Overcoming Barriers in the GI Tract Laura Ensign, Johns Hopkins Hospital, U.S.A. Overcoming Biological Barriers Dennis Discher, University of Pennsylvania, U.S.A. Predictive Animal Models for Assessing Long-Acting Formulations for Human and Animal Health and Their Challenges James Birchall, University of Cardiff, United Kingdom Proteins, Peptides, and Vaccines Maria JosĂŠ Alonso, University of Santiago de Compostela, Spain Transdermal Delivery Mark Kendall, University of Queensland, Australia

Nanoparticle-Based Delivery to the Brain Kannan Rangaramanujam, Johns Hopkins Hospital, U.S.A. 9

Mini-Symposia Mini-symposia offer in-depth knowledge into a specific area of delivery science and technology, featuring three invited speakers sharing their research on the topic. Topic descriptions can be found on the CRS website. Speakers are subject to change.

Advancements to Develop and Deliver Biologics Cosponsored by Catalent Pharma Solutions Stephen Buckley, Novo Nordisk A/S, Denmark Kang Choon Lee, SungKyunKwan University, Korea Rosie McLaughlin, Catalent Pharma Solutions, United Kingdom

Cancer Epigenetics, Epigenetic Drugs, and Delivery Rojgopal Govindarajan, University of Georgia, U.S.A. Vinod Labhasetwar, Cleveland Clinic Foundation, U.S.A. Shujun Liu, University of Minnesota, U.S.A.

Individualized Medicine and Theranostics Xiaoyuan Shawn Chen, NIH, U.S.A. Yong-Min Huh, Yonsei University, Korea Twan Lammers, Universiteit Utrecht, The Netherlands

Interspecies Clinical Pharmacology Dosing Concepts Robert Hunter, Elanco Animal Health, U.S.A. Mark Papich, North Carolina State University, U.S.A. Steven Sutton, University of New England, U.S.A.

Micro- and Nano-Encapsulation: From Innovation to Commercialization

ŠJens Goepfert /

David Dumbauld, Orbis Biosciences, U.S.A. Tom Tice, Evonik, U.S.A. Ron Versic, Ronald T. Dodge Company, U.S.A.


Roundtable Discussions Join your colleagues for these in-depth interactive sessions where a panel of experts will share their findings and opinions, creating an extended discussion on focused topics. This is a great opportunity to connect with colleagues with similar interests.

Ocular Drug Delivery Roundtable – Polymers in Ocular Drug Delivery – More Than Meets the Eye?

Young Scientist Roundtable – Imaging in Drug Delivery: Current Practice, Regulatory Challenges, and Future Trend

Tuesday, July 15

Sunday, July 13

Chaired by Ilva Rupenthal, University of Auckland, New Zealand, and Andrew Urquhart, Technical University of Denmark, Denmark

Cosponsored by Aspect Imaging

Topical application of eye drops is still the most common method for treating anterior segment diseases. However, the protective ocular barriers prevent achieving an effective drug concentration at the target site. Many polymers have been investigated over the years to overcome the poor drug bioavailability associated with conventional eye drops and to develop sustained release systems for intravitreal or periocular application. This session will focus on recent advances in polymeric formulations used for ocular drug delivery and will feature invited presentations followed by a panel discussion.

Chaired by Patrick Lim Soo, Blend Therapeutics, U.S.A., and Jinzi Zheng, Princess Margaret Cancer Centre, Canada Imaging has been increasingly exploited for assessment of the in vivo performance of drug delivery systems. These include nano-systems suitable for imaging and therapy, as well as functional and molecular imaging techniques capable of assessing the effectiveness of drug targeting and delivery. This roundtable aims to introduce young scientists to the current advances in the field and will discuss opportunities and strategies to achieve future successes in image-guided drug delivery.

Note that the focus group meeting will follow the roundtable discussion. 11

Get Up! Get Educated! Writing a Successful Grant Application Monday, July 14

Chaired by Joke Meeus, University of Leuven, Belgium, and Yewande Oni, University of Nottingham, United Kingdom It is currently essential for the majority of academic and industrial scientists to apply for funding. With many funding bodies available and increasing competition, how do we begin writing an application? This session will consult an experienced academic as well as a funding body representative. They will share their experiences and invaluable tips from their perspective. This session aims to teach you how to set your application apart from others and increase your chances of securing funding. Please indicate your attendance when registering. Complimentary event.

Evolution of Controlled Release R&D: From Pharmaceutics to Biopharmaceutics Tuesday, July 15

© Inozemtsev

Chaired by Yewande Oni, University of Nottingham, United Kingdom From the late 1900s the interest of pharmaceutical controlled release focused on compressed hydrophilic matrices. With current technological advancements, has this trend of interest ceased over the past six decades? This session will review the advances of controlled release technology from hydrophilic matrices to nanoparticle drug carriers and genetic engineering. How have these changes come about, and what are the future prospects for controlled release? Please indicate your attendance when registering. Complimentary event.


Young Scientist Mentor/Protégé Meet and Greet Sunday, July 13 Organized by the CRS Young Scientist Committee Are you interested in being a mentor or protégé? Provide your knowledge and encouragement to a young scientist or receive expertise and experience from academics or industry scientists for your professional and career development. Preregistration for the 2014–2015 CRS Young Scientist Mentorship Program is required. Do not miss this exciting session for the opportunity to meet face-to-face with your mentor or protégé. “Tell me and I forget, teach me and I may remember, involve me and I learn.” – Benjamin Franklin Premeeting registration required. A limited number of mentors and protégés are accepted into the program.

Posters CRS Posters and Poster Author Sessions Delve into the discovery, development, and delivery continuum by viewing the more than 500 posters over three days. All scientific posters will be set up and available for viewing Sunday evening during the Exposition Grand Opening & Welcome Reception and all day Monday and Tuesday. Three poster author sessions are scheduled on Monday and Tuesday. One-third of poster authors will be present at each session. 13

CRS Innovation Sunday—Delivery Science Meets Business Opportunities Sunday, July 13 Cosponsored by Pfizer CRS Innovation Sunday is all about the business of delivery science, taking innovative ideas and technologies into the commercial sector. All of these sessions give you important new information on companies and technologies as well as great opportunities for networking face-to-face. This is the start of the CRS Annual Meeting program—don’t miss it!

Technology Forums Are you interested in learning more about a company’s research and products? Interested in a new technology from the company that developed it? Open to all registered attendees, Technology Forums give you the opportunity to gain in-depth information presented by the hosting company. Presentation titles, details, and speakers are posted on the CRS Innovation Sunday webpage for these participating companies: Catalent Pharma Solutions Evonik Corporation Purac Corbion Biomaterials Gattefossé Corporation Nanomi SE Tylose USA Inc.

Soapbox Sessions Cosponsored by Catalent Pharma Solutions What’s new in delivery science? Come to the program where presenters “get up on their soapbox” to give you a quick glimpse of some of the most innovative technologies and products in development today. Linger to network with the presenters as you enjoy refreshments, with thanks to our sponsor. Soapbox applications will be received and reviewed until the session is full. Watch the CRS Innovation Sunday webpage for topics and presenters. 14

Industry Roundtable: Patient Adherence and the Future of Innovative Drug Delivery Patient non-adherence to medication takes a huge toll on healthcare budgets and on human health. Estimates indicate that in the United States alone, non-adherence to prescription regimens wastes roughly $300 billion in healthcare system costs and results in approximately 125,000 preventable deaths each year. Solving the adherence challenge is now as critical as finding the next new drug and will profoundly impact the future direction of drug delivery. This Industry Roundtable will discuss perspectives and provide insight on the latest innovative delivery technologies, devices, packaging, patient interactive feedback systems, and other future strategies to increase patient adherence and treatment outcomes.

Premeeting Workshops These workshops offer focused presentations on specific topics by noted speakers and are open to a limited number of participants for an additional fee.

Albumin: The Next Generation Protein Therapeutic

Oral Delivery of Peptides and Proteins

Saturday, July 12 (Full day)

Saturday, July 12 – Sunday, July 13 (1 ½ days)

Chaired by Kenneth Howard, Interdisciplinary Nanoscience Center, Denmark

Chaired by David Brayden, University College Dublin, Ireland, and Randall Mrsny, University of Bath, United Kingdom

Albumin is the most abundant human plasma protein that exhibits prolonged circulatory half-life and a predominant role in extracellular and intracellular transport of nutrients. These properties can be exploited for extended half-life and targeted drug delivery. Relevant biological mechanisms such as molecule binding, cellular receptor engagement and recycling, and its tuning through recombinant technology for modulation of pharmacokinetics will be addressed. Clinical development and commercial albumin-based drug products such as albumin-binding prodrugs, genetic fusions, and nanoparticles highlight albumin’s emergence as the next-generation protein therapeutic.

Oral delivery of peptides and proteins is regarded as one of the great challenges for drug delivery. After a slump in interest in the mid-1990s, at least 12 technologies with selected peptides are now in clinical trials. The workshop will assess the current status of this revitalized field, exploring how selected technologies work and whether they can be applied to a range of peptide and protein-based payloads. Key aspects to be discussed are the rationale for payload and technology selection, repeat oral dose toxicology, and arguments for parenteral-to-oral switching.

Early Regular/Onsite Workshop Price (by May 1, 2014) (after May 1, 2014) Regular $350 $400 Student/Postdoc $160

Early Regular/Onsite Workshop Price (by May 1, 2014) (after May 1, 2014) Regular $525 $625 Student/Postdoc $250



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Premeeting Workshops (continued) Nanotechnology – Technology and Applications Saturday, July 12 – Sunday, July 13 (1 ½ days) Chaired by Nicole Papen-Botterhuis, TNO, The Netherlands, and Teresa Virgallito, Microtek Laboratories, Inc., U.S.A. Nanotechnology is a broad term that covers many areas of science, research, and technology. In the next 20 years, nanotechnology will touch the life of nearly every person on the planet. The workshop will cover process and formulation, characterization of nanosystems, applications of nanotechnologies in various industries, and regulatory compliance for nanotechnology for consumer products. The workshop will provide an overview of nanotechnology and the impact of the technology on the developing world. Learn how nanotechnology is being applied in a broad range of consumer products.

Early Regular/Onsite Workshop Price (by May 1, 2014) (after May 1, 2014) Regular $525 $625 Student/Postdoc $250 $300


Computational Pharmaceutics – The Application of Computer Modeling in Drug Delivery Sunday, July 13 (½ day – Morning) Chaired by Alex Bunker, University of Helsinki, Finland, and Defang Ouyang, Aston University, United Kingdom This workshop will focus on the application of molecular modeling techniques in drug delivery—named as “computational pharmaceutics.” The workshop will discuss the modeling of different drug delivery systems, such as cyclodextrins, solid dispersions, liposomes, polymer coating of delivery systems, particulate media, protein/peptide formulations, nonviral gene delivery systems, and surface modification, and three important methodological areas: pharmacokinetic modeling, molecular modeling, and synchrotron radiation micro-computed tomography (SR-μCT) combined with in silico 3D reconstruction. Early Regular/Onsite Workshop Price (by May 1, 2014) (after May 1, 2014) Regular $200 $225 Student/Postdoc $125 $145

Locally Acting Dermal Drug Products – Global Challenges for Development and Registration Sunday, July 13 (½ day – Morning) Chaired by Tapash Ghosh, ONDQA/CDER/FDA, U.S.A., and Howard Maibach, University of California, U.S.A. The workshop will bring a sound understanding of topical dermal products across multiple disciplines and multiple sectors. It will also discuss the challenges associated with demonstration of bioequivalence for topical products, from both new and generic drug perspectives, in light of the considerations for future regulatory submissions. Alternative and novel technologies for determining bioequivalence of topical drug products, as well as the value of in vitro drug release in semisolid dosage forms, will also be discussed. Early Regular/Onsite Workshop Price (by May 1, 2014) (after May 1, 2014) Regular $200 $225 Student/Postdoc $125 $145 17

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Young Scientist Workshops The Young Scientist workshops are specifically designed with the interests of young scientists in mind. Young scientists are typically students and early career scientists under the age of 40 years, or those with less than five years’ experience in the field of delivery science.

The Science of Publishing Saturday, July 12 (Morning) Chaired by Adam Bohr, Institute Galien ParisSud, France, and Jorrit Water, University of Copenhagen, Denmark Publishing is the cornerstone of scientific research and of great importance in the career of every academic. This workshop aims to educate young scientists in the different aspects of publishing and peer review in scientific journals, as well as highlight and discuss current controversies such as open access journals, scientific integrity, impact factors, and more. The workshop will be presented by prominent editors and publishers of well-established pharmaceutical journals. The workshop is open to all conference attendees. Please indicate your attendance when registering. Complimentary event.


Novel Technologies in Solubility Enhancement Saturday, July 12 (Afternoon) Chaired by Marcus Brewster, Johnson & Johnson, Belgium, and Joke Meeus, KU Leuven, Belgium Contemporary drug pipelines contain an increasing number of poorly water-soluble candidates. To overcome this problem, solubilityenhancing technologies often focus on impacting aspects of the Noyes–Whitney relationship by increasing dissolution rate or drug solubility. In view of this, the workshop aims to provide a context for deciding whether formulation enablement is necessary and which technique is most appropriate for which problem. Moreover, novel screening, analytical, and manufacturing approaches are within the scope of this training forum. Please indicate your attendance when registering. Complimentary event.

Communication and Networking: How to Develop and Utilize These Skills for a Successful Career Sunday, July 13 (Morning) Chaired by Shahriar Absar, FDA, U.S.A., and Kaushal Dave, South Dakota State University, U.S.A. In this modern era of technology, networking and communication have become integral components of a successful career either in academia or in industry. While scientific meetings have long served as the platform for networking with professionals across the globe, online sites have also become critically important to widening one’s professional network. This workshop will feature speakers that are experts in the field and will outline the tools that are necessary to sharpen communication and networking skills. Please indicate your attendance when registering. Complimentary event.

Networking Opportunities CRS Connect

First Timers’ Meeting

As a CRS Annual Meeting attendee, CRS Connect is your premier opportunity to network with colleagues while in Chicago. As a component of the CRS Meeting App, CRS Connect is easily accessible from your mobile phone, tablet, or computer. This networking tool allows you to plan the scientist-to-scientist or business development collaborations you seek at the annual meeting while maintaining your full privacy, as personal contact information is never shared.

Sunday, July 13 Plan to attend this special meeting where CRS leaders and seasoned meeting attendees will provide suggestions to help you make the most of your first meeting experience. Please indicate your attendance when registering. Complimentary event.

Women in Science Luncheon: In the Middle of Difficulty Lies Opportunity Monday, July 14 Moderator: Debra Bingham, Valeo Partners, U.S.A. Speaker: Danchen Gao, Abbvie, U.S.A. This year’s lunch will feature a fireside chat with Danchen Gao, Director, Intellectual Property Strategy, Abbvie. Don’t miss this popular annual event, which provides an insightful and informational presentation along with ample time for networking. Danchen Gao

Advance registration and payment required. Ticket price $30.

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Networking Opportunities (continued) PSAH Networking Get-Together

Young Scientist Networking Event

Monday, July 14

Monday, July 14

Organized by the PSAH Division

Organized by the Young Scientist Committee

Cosponsored by Merial Ltd.

Cosponsored by Diurnal Limited and Upsher-Smith Labs

Join members of the CRS Preclinical Sciences & Animal Health (PSAH) Division and fellow meeting attendees at Chicago’s premier blues club, Buddy Guy’s Legends. The event is directly across the street from the Hilton and will begin with a brief presentation about the division and its involvement within CRS. Afterward, attendees can enjoy networking in this unique venue owned by six-time Grammy Award–winning artist Buddy Guy. You do not need to be a member of the PSAH Division to attend.

Join your colleagues for an enjoyable evening of networking aboard the Mystic Blue yacht when you attend the popular Young Scientist Networking Event. Reunite with familiar faces and make new connections as you enjoy a two-hour boat cruise on Lake Michigan. The yacht will depart from and return to Navy Pier, offering spectacular panoramic views of Chicago’s world-famous skyline.

Advance registration and payment required. Ticket price $10. Included in the ticket price are hors d’oeuvres, one drink ticket, and a wristband for admittance into the nighttime live show at the venue.

Advance registration and payment required. Ticket price $50, which includes boat ride, hors d’oeuvres and a drink ticket.

C&DP Division Luncheon Tuesday, July 15 Organized by the C&DP Division Cosponsored by Coating Place Inc., The Dow Chemical Company, Microtek Labs Inc, Ronald T. Dodge Co., and Vision Processing Technologies Inc. Join your fellow Consumer & Diversified Products Division members for this networking buffet luncheon at the Hilton Chicago. All attendees interested in C&DP, which includes encapsulation and controlled release research for food, nutraceuticals, personal care, cosmetics, home care, agriculture, textiles, and coatings, are welcome to attend. Advance registration and payment required. Ticket price $15.


CRS Foundation

Alexandar “Sandy” Florence

CRS President’s Banquet

Founded in 2007, the CRS Foundation honors leaders who have made notable contributions to delivery science and supports the scientific training of its future leadership. Thanks to generous donors, more than $120,000 has been raised for postdoctoral fellowships that expand research and travel opportunities for outstanding young scientists. Please help the Foundation expand its fellowships by giving annually. The 2014 fellowship honors Alexander “Sandy” Florence.

Tuesday, July 15 The President’s Banquet is a premier opportunity to meet and dine with your colleagues from around the world. Come to meet up with friends, create new friendships, and celebrate a successful CRS Annual Meeting! One drink ticket is included with your dinner. Cash bar available. Advance banquet ticket purchase is strongly recommended. Availability of onsite banquet tickets cannot be guaranteed.

Donate when you register for the annual meeting. FOUNDATION

Advance registration and payment required. Ticket price $95. 21

Exposition and Sponsorship Exposition Hall Activities

©City of Chicago

Come to the Exposition Hall for discovery, solutions, opportunities, and refreshments! Starting off with the Sunday evening Exposition Grand Opening & Welcome Reception, the Exposition/Poster Hall will also be open Monday and Tuesday as the central hub for poster viewing, program breaks, and refreshments. Be sure to thank the CRS Café Sponsors (*) for providing complimentary beverages. 3M Drug Delivery Systems Adhesives Research Advanced Polymer Materials Inc. Agilent Technologies Akina, Inc.: PolysciTech Division Anton Paar USA Avanti Polar Lipids Inc. Bend Research Inc. Buchi Catalent Pharma Solutions Celanese EVA Performance Colorcon* CordenPharma Croda Inc. Delta Industrial Services Inc. Dissolution Technologies Distek Inc. Drug Development & Delivery DURECT Corp./Lactel Absorbable Polymers* EMD Millipore Erbo Spraytec AG 22

Evonik Degussa/Pharma Polymers Fluid Imaging Technologies Formex, LLC Freund-Vector Corp. Gattefossé Gaylord Chemical Company Hanson Research Corp Hovione LLC Intec Pharma Ltd. Izon Science KORSCH America, Inc. Lipoid LLC Logan Instruments Corp. Medimetrics NanoImaging Services Nisso America Inc. NOF America Corp. Northern Lipids Incorporated Novozymes Biopharma OctoPlus NV Patheon Pharmaceuticals Services Inc.

Pharmaceutical Technology Polymicrosheres-Advanced Nanotechnologies Polymun Scientific Immunbiologische Forschung GmbH Polysciences Inc. ProMed Pharma LLC Purac Corbion Biomaterials SE Tylose USA Siegfried USA, LLC Simulations Plus Inc. SOTAX Corp. Southwest Research Inst Springer Surface Measurement Systems Technology Catalysts Intl. Texture Technologies* Vision Processing Technologies Inc. Wyatt Technology

Sponsors Make It Happen Many of the annual meeting events are possible only through the generosity of sponsors. Please join CRS in thanking the following 2014 sponsors, current as of February 12, 2014: 3M Drug Delivery Systems Aspect Imaging Catalent Pharma Solutions Coating Place Inc. Colorcon Croda, Inc. Diurnal Limited The Dow Chemical Company DURECT Corp./Lactel EMD Millipore Merial Ltd.

Interested in Exhibiting or Sponsoring? Connect with the CRS international delivery science community.

Contact Cindy Anderson, Director of Sales +1.651.994.3848

Microtek Labs Inc. Patheon Pharmaceuticals Services Inc. Pfizer PharmaCircle Ronald T. Dodge Co. Texture Technologies Upsher-Smith Labs Vision Processing Technologies Inc. Zoetis

Registration Information Registration Options ➤ Register online at ➤ Print and complete the registration form found online at

2014 CRS Registration Fees All CRS Annual Meeting & Exposition registration fees are in U.S. dollars (USD). Early Regular/Onsite Registration Classification (by May 1, 2014) (after May 1, 2014) Member $855 $1,055 Student Member $305 $395 Post-doc Member $350 $440 Meeting + Membership Registration + Regular Membership $1,025 $1,225 Registration + Student Membership $358 $448 Registration + Postdoc Membership $410 $499 Nonmember $1,030 $1,229 Student/Postdoc Nonmember $405 $495 Single Day $675 $725 (Sunday, Monday, Tuesday, Wednesday)

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Registration Information (continued) Exhibitor Registration Each exhibiting company is entitled to a specified number of complimentary annual meeting registrations based on exhibit size. Please see the Exhibitor Checklist on the CRS Annual Meeting & Exposition website for more information and to register each exhibitor individually with the customized form. Complimentary allotment: Space 10 × 10 Foot Booth 10 × 20 Foot Booth 6 × 2 Foot Tabletop

Complimentary Registrations 2 Full Program + 2 Exhibit Personnel 4 Full Program + 3 Exhibit Personnel 1 Full Program

Rates for exhibitors beyond the complimentary allotment are: Exhibitor Full Program Exhibitor Personnel Add CRS Membership

Early Regular/Onsite (by May 1, 2014) (after May 1, 2014) $765 $995 $345 $345 $172 $172

Annual meeting registration includes access to the following: Abstracts (available June 13, 2014) CRS Connect CRS Innovation Sunday Sessions Exposition Focus Groups Grand Opening & Welcome Reception Get Up! Get Educated! Sessions

Podium and Poster Scientific Sessions Technology Forums Roundtable Discussions Soapbox Sessions Young Scientist Events

(except as noted)

Tickets must be purchased for all premeeting workshops, C&DP Luncheon, CRS President’s Banquet, PSAH Networking Get-Together, Women in Science Luncheon, and Young Scientist Networking Event. Please indicate your attendance for the free workshops and events scheduled throughout the week so that we may plan accordingly. Tickets are limited for some events, and early registration is recommended. The deadline for early annual meeting registration is May 1, 2014.

Member Rates Discounted member rates apply only to current paid members of the Controlled Release Society. If you are not a current member of CRS, renew or join when you register to take advantage of everything that CRS membership has to offer.

Full-Time Student/Postdoc Rates Full-time students and postdocs qualify for discounted registration rates. Proof of graduate student or postdoctoral research status will be required when registering for the annual meeting.


Cancellation Policy Cancellations must be made in writing and be received by CRS no later than June 2, 2014. Cancellations received by this date are subject to a $100 processing fee. Ticketed events will be fully refunded before this date. CRS Annual Meeting & Exposition registration and ticketed event cancellations received after June 2, 2014, are not subject to refund.

Payment Payment must accompany your registration. Registrations will be charged in U.S. dollars. Payment vouchers or purchase orders are not considered payment. Registration options are: Credit card: Pay when registering online, or fax (+1.651.454.0766) or mail (see address below) the completed form with credit card information. For security reasons, we do not recommend sending your credit card information via e-mail. Check: Mail the completed form and check payment to: CRS Meeting Registration 3340 Pilot Knob Road St. Paul, MN 55121 U.S.A.

Attire and Weather Business casual is the recommended dress for the CRS Annual Meeting & Exposition. Comfortable walking shoes and casual, light-weight layered clothing are recommended for after-meeting activities. The average midJuly high temperature in Chicago is 83°F (28°C). The average evening low temperature is 62°F (17°C).

Emergency Information If you have a medical condition that CRS should be aware of during the meeting, please fax your information to CRS Annual Meeting & Exposition, +1.651.454.0766 or e-mail to This information should be received no later than June 1, 2014, and is optional. Your information will not be shared with anyone, except in case of emergency, and then only with emergency personnel.

ADA/Special Requests For full and equal enjoyment of the CRS Annual Meeting & Exposition, please tell us of any special requirements you may have in the “Special Accommodation” area of the registration form, and a CRS staff person will contact you to further discuss your needs.

Program Modifications All information is subject to change without notice.

Official Language English is the official language of the CRS Annual Meeting & Exposition.

Photo Release Many photographs will be taken throughout the CRS Annual Meeting & Exposition and are used in CRS electronic and printed promotional materials during the meeting and after it has concluded. By virtue of your attendance, you agree to the Controlled Release Society’s use of your likeness in said promotional media. 25

Meeting & Hotel Information All scientific sessions, poster sessions, the exposition, and the welcome reception will take place at: Hilton Chicago—CRS Headquarters Hotel 720 Michigan Avenue Chicago, IL 60605 U.S.A. +1.312.922.4400 CRS has reserved a block of rooms at the Hilton Chicago, at discounted rates. Detailed hotel information and booking instructions for reserving rooms online or by telephone can be found on the CRS Annual Meeting & Exposition website, meeting. Reservation Deadline: June 18, 2014 Room Types and Rates* Standard $236 Single or Double occupancy 2 Bed/2 Bath $256 Single or Double occupancy Lake View $256 Single or Double occupancy Executive Level $296 Single or Double occupancy All hotel rates are in U.S. dollars (USD). Tax on guest rooms is presently 16.4% (subject to change). CRS discounted room rates are available three days before and after annual meeting dates, based on availability. *Rates do not include tax.


Chicago: Hub of the Midwest and World Class Destination Besides its striking downtown, which includes some of the tallest buildings in the world, Chicago has a distinctive coastline, hundreds of vibrant parks, and more than 200 unique neighborhoods. In Chicago you will find incredible shopping on The Magnificent Mile, a Michelin-rated dining scene, and exciting nightlife. The city also boasts of more than 40 museums, five regional Tony Award–winning theaters and, no matter the season, a sports team to cheer to victory. Chicago’s neighborhoods represent more than 100 countries, and it is through this diversity and profound city culture that they are able to develop the country’s best restaurants, theaters, and museums. Enjoy your visit to Chicago.

Getting to Chicago

Situated in the center of the United States, Chicago is easy to travel to from virtually everywhere. Thanks to thousands of flight options at two international airports, six class-one railroads, a vast network of major highways, and a wide variety of airlines, it is one of the most cost-competitive and convenient cities to visit. Specific travel details can be found on the CRS website.

(Left to right) Courtesy of Choose Chicago, ©City of Chicago – Adler Planetarium Chicago; Ferris Wheel at Night Navy Pier; Riverboat cruise through the city and past Willis Tower

International Travel

The U.S. Department of State encourages you to apply for your visa as soon as possible. The U.S. government is working to expedite visa processing; however, visas can take up to three months to obtain, so we encourage you to plan ahead to avoid any delays. The process of applying for your visa may have changed from the last time you applied or may take longer. If you have any difficulty obtaining a visa for the meeting, visit annual/travel/ for more details. Letters of invitation are provided to attendees from outside the United States after they have registered for the meeting. 27

Controlled Release Society 3340 Pilot Knob Road St. Paul, MN 55121 United States of America

41st Annual Meeting & Exposition of the Controlled Release Society

of Delivery Technology: Innovation to Commercialization

➤ Register Now!

July 13 – 16, 2014 The Hilton Chicago Chicago, Illinois, U.S.A.

2014 CRS Annual Meeting & Exposition Registration Brochure  
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