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TROLAB速 Patch test allergens

June 2009


TROLAB Patch test allergens

AII TROLAB Patch Test Allergens are registered as MEDICINES in Germany with the Paul Ehrlich Institute, Langen.

1


2


Index Page

Patch testing with TROLAB速 allergens

5/6

Application of test substances

6-11

Interpretation of test results

12

Information on the irritancy control patch test with Sodiumlaurylsulfate (SLS) 0.25 % in water 13-16

Storage and shelf life

16

Screening series:

17-38

Baseline Series (European)

BS

17/18

Control irritant

IR

Antioxidants

AO

19

Bakery Allergens

BA

19

Cosmetics

COS

20

Cutting Oils I (current)

CO I

21/22

Cutting Oils II (historical)

CO II

22

Dental Materials

DM

23

19

Disinfectants

DIS

24

Epoxy Resin Systems

ERS

24

Hairdressing

HD

25

Industrial Biocides

IB

Medicaments I - Antibiotics

ME I

26

Medicaments II - Antiseptics, Antimycotics

ME II

26

25/26

Medicaments III - Miscellaneous

ME III

27

Medicaments IV - Local Anaesthetics

ME IV

27

Medicaments V - Corticosteroids

ME V

27

Medicaments VI - Ophthalmics

ME VI

28

Metal Compounds

MC

28

Methacrylates

MA

28/29

Perfumes, Flavours

PF

29-31

Photoallergens

PA

31/32

3


Photographic Chemicals

PC

32

Plants

PL

33

Plastic Materials

PM

33

Preservatives

PR

34

Rubber Chemicals

RC

35

Shoe Allergens

SH

36

Sunscreen Agents

SA

36

Textile and Leather Dyes

TD

37

Vehicles, Emulsifiers

VE

37/38

Miscellaneous

MIC

Service Items

38

38

International Standard Series of Patch Testing

39/40

List of test substances

41-49

List of INCI names for TROLAB速 substances

50-53

Ordering procedure

54

List of TROLAB distributors

4

54-57


Patch testing with TROLAB allergens Patch testing is the most important diagnostic and investigative method currently available for studying allergic contact dermatitis in clinical practice. The method includes the epicutaneous application of a specific allergen at a defined concentration and in a defined vehicle which will induce a cutaneous inflammatory reaction in a sensitised person, but will cause no reaction in a non-sensitised person. TROLAB patch test allergens have always been developed, revised and produced following the recommendations of the International Contact Dermatitis Research Group (ICDRG) and the European Environmental and Contact Dermatitis Research Group (EECDRG). Their many years experience helped us to select the test substances and determine test concentrations and test vehicles, so that generally the test allergens do not trigger toxic reactions whilst allergic ones can be induced. Today we add new test allergens to the TROLAB programme only, if test concentrations and vehicles have been proven and confirmed in clinical trials. TROLAB patch test allergens are dispersed in petrolatum (if no other vehicle is indicated) and filled in 5 ml syringes. Some test allergens contain additives like e.g. sorbitan sesquioleate or solid paraffin. These additives are indicated on the syringe lable. Almirall’s experience as a pharmaceutical company specialising in the production of topical dermatological products also guarantees that the patch test allergens are produced in a high galenic quality.

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TROLAB patch test allergens are produced in accordance with the WHO guidelines of Good Manufacturing Practice. Raw materials are selected carefully. The allergens are homogenously incorporated into the ointment in the form of extremely small particles. The stability of the final product is checked by chemical analysis. AII TROLAB Patch Test Allergens are registered as MEDICINES in Germany with the Paul Ehrlich Institute, Langen. Our overall objective is to offer our customers high quality standardised patch test allergens. However, it should be noted that the interpretation of the test results requires much experience on the part of the testing physician, i.e. careful anamnesis and examination of the clinical findings for the final assessment of the relevance of the test results.

Application of test substances TROLAB patch test allergens can be used with all types of patch test plaster. Very well accepted are Finn Chambers on Scanpor*. It is important to consider that all test concentrations were defined by using this test plaster.The following description is for using Finn Chambers on Scanpor (for other test plasters please follow instructions of manufacturers).

*Product/Trademark of Epitest Ltd. Oy, Finland

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Fig. 1: Marking of the test tape

When using Finn Chambers on Scanpor, the serial numbers of the substances to be tested must be clearly marked on the upper side of the adhesive tape (Fig. 1), for example: S1 - S10 (Standard, substances 1-10). The small tape sections carrying the numbers will later remain on the skin and allow to perform the reading with the practical Reading Plate*.

Fig. 2: Removal of the protective foil

Remove the protective foil.

*Product/Trademark of Epitest Ltd. Oy, Finland

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Fig. 3: Application of test ointments

Place the test tape in front of you, as shown in Fig. 3. Now you can fill the chambers downward starting on the top right row. The test ointments are applied directly into the aluminium chambers (Fig. 3). The chambers must never be filled completely but only slightly more than half-full (5 mm length). No substance should be brought on the rim of the chamber!

Fig. 4 a + 4 b : Application of test solutions

When using test solutions, a filter paper disc has to be placed into the chamber first (Fig. 4 a). The filter paper has to be saturated with one drop

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of the test solution (Fig. 4 b). Please avoid excess. On the other hand, the filter paper disc must not dry up, as in that case false-negative test results would have to be expected. We recommend to prepare the plaster just before applying it to the patient’s skin in order to achieve relevant test results. The test tapes that have been prepared as described are applied to the back in normal upright position, with the lower margin being fastened first. Thereafter they are pressed against the skin with

Fig. 5 a + 5 b: Application of the test tape

the palm, gradually from bottom to top, and then carefully stroked down. The air can thereby escape from the chambers and a good fixation is achieved. Subsequently, the test chambers are again pressed against the skin two to three times, exerting slight pressure with the fingers in order to spread the test substances evenly on the skin (Fig. 5 a + 5 b). The adhesive tapes should be applied only to the clean and dry skin (non-greasy, no ointment residues etc.). You might use diluted alcohol to clean the skin.

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Fig. 6: Preparations for the reading by means of the Reading Plate

The Reading Plate is a simple aid to recognize the test reactions without having to mark the skin of the patient with ink. As a preparation for the reading, before the test chambers are filled, the numbers of the substances to be applied have already been noted on the upper ends of the adhesive tapes (see Fig. 1). Fig. 6 demonstrates how to use the Reading Plate when the adhesive tape is removed (usually after 48 hours). The cutting edge of the plate is slightly pressed against the test tape at an angle of about 45 degrees. The broader side of the plate should thereby be held on the left. Now, grasp the test tape and tear it off in a brisk upward movement, thereby leaving the strip (about 1 cm wide) where the numbers are marked (Fig. 7). After the removal of the Finn Chambers on Scanpor, circular imprints on the skin reveal whether the test provided adequate occlusion. If these imprints are not visible, the test has to be repeated (it is known from experience that this rarely happens if the adhesive test tapes were properly applied).

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Fig. 7: Reading by means of the Reading Plate

Fig. 7 demonstrates how the Reading Plate is used during the first as well as during the subsequent readings when the circular imprints of the test chambers on the skin have already disappeared. Place the left corner of the Reading Plate on the left corner of the remaining strip of the adhesive tape. The holes in the plate now indicate the locations of the test sites. Please note:

The first reading should be performed about 20 to 30 minutes after the removal of the tape, as some skin sensitive persons will react with redness after tape removal. Excessive test ointments have to be carefully removed with an individual swab for every substance prior to the first reading. Make sure not to wipe the excessive ointments into the adjacent test areas. If no Reading Plate is available, the locations of the individual test chambers have to be marked on the skin with a suitable marking pen before removing the test tape, so that positive test results can be clearly identified during further readings after 72 and 96 hours.

11


Interpretation of test results When recording the results in the patient’s test sheet, it is important to score according to the reaction actually seen and not according to the subjective interpretation placed on the reaction by the reader. Irritant reactions should be recorded as positive irritant (IR) and not as negative. To recognize irritant reactions it may be helpful to know of the irritability of the skin at the test side and the time of testing. Almirall is offering Sodiumlaurylsulfate (SLS) 0.25 % in water as a control irritant for patch testing. Information on the irritancy control patch test with SLS 0.25 % in water can be found on the following pages. Recording of patch test reactions Score ?+ + ++ +++ IR NT

Morphology no reaction faint erythema only erythema, infiltration, possibly papules erythema, infiltration, papules, vesicles intense erythema and infiltration and coalescing vesicles irritant reactions of different types

Interpretation negative doubtful reaction weak positive reaction strong positive reaktion extreme positive reaction irritant reaction not tested

Whether or not the positive test reaction demonstrated by the patch testing is relevant to the patient’s dermatitis, either as the primary cause or as an aggravating factor, must be determined by the critical judgement of the physician. If the clinical and historical facts are consistent with the patch test result, one can be reasonably certain of its significance. In doubtful cases, a repeated open application test (ROAT) in the antecubital space or on the outer aspect of the upper arm may be helpful.

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Information on the irritancy control patch test with Sodiumlaurylsulfate (SLS) 0.25% in water Why to do an irritancy control when patch testing with contact allergens. Every contact allergen produces an irritancy effect on the skin to some degree. It is thought that this irritancy is important for a substance to be able to act as a contact allergen. Due to this particular property, irritant or false positive test reactions may occur in diagnostic patch testing with contact allergens. The frequency and extent of such unwanted reactions differ not only between allergens but also between individuals, depending on their particular sensitivity to irritants. This irritability may vary between different skin regions and over the course of time. Therefore, the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe ; DKG) recommends to perform an irritancy control patch test when patch testing with contact allergens, in order to assess the individual sensitivity to irritants at the time of patch testing in the test area. Which irritant is suitable? There are different kinds of irritants, e.g. weak bases or acids, or detergents, which disturb the epidermal barrier. For the purpose of an irritancy control patch test, Sodiumlaurylsulfate (SLS) has proved useful. SLS is not an allergen and, tested at a low concentration it causes visible reactions only in very sensitive individuals. DKG studies have shown that patients, in whom SLS 0.25 % in water elicited an irritant reaction, had questionable and weak positive patch test reactions to contact allergens more frequently than others. In most cases, these patch test reactions, too, are irritant, and not allergic, reactions. Thus, patch testing with the irritant SLS 0.25 % in water as a marker for sensitive

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skin facilitates the assessment of erythematous and weak positive patch test reactions to contact allergens. How to perform and read the SLS patch test and how to interpret the results. The irritancy control patch test with SLS 0.25 % in water is performed in exactly the same manner as the classical contact allergen patch test. For reading and assessment of the test reactions, the DKG recommends the following categories (modified from Tupker et al. 1997): Score sls0 sls1 sls2 sls3 sls4

Morphology no reaction very weak/slight erythema or scaling (spotty or diffuse) weak/slight erythema, scaling oedema or roughness moderate erythema, scaling, oedema or roughness, or weak/slight erosions, vesicles or fissures strong erythema, scaling, oedema or roughness, or clear erosions, vesicles or fissures

Interpretation negative doubtful weak moderate strong

When patch testing with SLS 0.25 % in water, only very rarely reactions of grade sls3 or sls4 occur. In the DKG studies, less than 30 % of the patients tested had a reaction; most of the reactions were classified as sls1 or sls2. In patients having a visible reaction of this kind, an increased irritability of the skin is probable.

sls1 - Reaction

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sls2 - Reaction (focus on scaling)

sls2 - Reaction (focus on oedema)

Significance and limitations of the irritancy control patch test. An irritant reaction (sls1 or stronger) to SLS 0.25% in water does not automatically mean that every weak patch test reaction to an allergen is also an irritant; however, the probability that an irritant erythema or a weak false positive reaction occurs in this patient is markedly higher. This is particularly true for test allergens known to have an increased irritant potential. The irritancy control patch test facilitates the assessment of this kind of test reactions; however, it does not replace the need for a thorough interpretation of the test reactions (allergic versus irritant) by the physician and for the assessment of clinical relevance. 15


As mentioned above, the irritability of the skin may vary between body regions and over the course of time. Thus, the irritancy control patch test with SLS only gives information about the irritability of the test region (upper back) at the time of patch testing. It can be considered a regionally limited snapshot, which does not allow any generalisation concerning the patients’ skin irritability. References: Brasch J, Becker D, Effendy I: Reproducibility of irritant patch test reactions to sodium lauryl sulfate in a double-blind placebo-controlled randomized study using clinical scoring. Results from a study group of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG). Contact Dermatitis 41, 150-155 (1999) Geier J, Uter W, Pirker C, Frosch PJ: Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant.Contact Dermatitis 48, 99-107 (2003) Löffler H, Becker D, Brasch J, Geier J for the German Contact Dermatitis Research Group (DKG): Simultaneous sodium lauryl sulfate testing improves the diagnostic validity of allergic patch tests. Results from a prospective multicentre study of the German Contact Dermatitis Research Group (Deutsche KontaktallergieGruppe, DKG)British Journal of Dermatology 152, 709719 (2005) McFadden JP, Basketter DA: Contact allergy, irritancy and ‚danger‘.Contact Dermatitis 42, 123-127 (2000) Tupker RA, Willis C, Berardesca E et al.: Guidelines on sodium lauryl sulfate (SLS) exposure testing. Contact Dermatitis 37, 53-69 (1997)

Storage and shelf life For each individual TROLAB allergen storage conditions are mentioned on the label. TROLAB allergens should not be used after the expiry date!

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BS

TROLABÂŽ Baseline Series (European)

The Baseline series consists of the minimum recommended test set to be used during routine diagnostic patch test investigations and which will be ordinarily supplemented by additional series and other allergens as appropriate to adequately investigate the clinical problem. Assuming that this recommandation is followed we have not placed any substance from the Baseline series in one of the other series to avoid double patch testing. The only exception is the Fragrance Mix (E0029) which is also included in the series Photoallegens. Serial No.

Substance

1

Potassium Dichromate

2

Neomycin Sulphate

3

Concentration

0.5

Thiuram Mix

Art. No.

% E0001

20

% E0010

1

% E0023

14

% E2860

(Tetramethylthiuram Disulphide,Tetraethylthiuram Disulphide, Tetramethylthiuram Monosulphide, Dipentamethylenethiuram Disulphide; 0.25 % each)

4

Fragrance Mix II

(alpha-Hexyl cinnamaldehyde 5 %, Citral 1 %, Citronellol 0.5 %, Farnesol 2.5 %, Coumarin 2.5 %, Hydroxymethylpentylcyclohexenecarboxaldehyde 2.5 %)

5

Cobalt Chloride, 6H2O

1

% E0002

6

4-Phenylenediamine free base

1

% E0034

7

Benzocaine

5

% E0011

8

Formaldehyde (in water)

1

% E0004

9

Colophony

20

% E0017

9

Clioquinol

5

% E0015

25

% E0008

11

Balsam of Peru

12

N-Isopropyl-N’-phenyl Paraphenylenediamine

13

Wool Alcohols

14 15

0.1

% E1004

30

% E0020

Epoxy Resin

1

% E0021

Mercapto Mix

1

% E0025

0.1

% E2504

(N-Cyclohexylbenzothiazyl Sulphenamide, Dibenzothiazyl Disulphide, Morpholinylmercaptobenzothiazole; 0.33 % each)

16

Budesonide 17


Serial No.

Substance

Concentration

BS

Baseline series continued 17

Paraben Mix

Art. No.

16

% E2469

Paratertiarybutyl Phenol Formaldehyde Resin 1

% E0030

Fragrance Mix

8

% E0029

(Methyl Parahydroxybenzoate, Ethyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Butyl Parahydroxybenzoate; 4 % each)

18 19

(Cinnamyl Alcohol, Cinnamaldehyde, Eugenol, alpha-Amyl-Cinnamaldehyde, Hydroxycitronellal, Geraniol, Isoeugenol, Oak Moss Absolute; 1 % each; Sorbitan Sesquioleate 5 %)

20

Quaternium-15

1

% E0031

21

Nickel Sulphate, 6H2O

5

% E0003

22

5-Chloro-2-methyl-4-isothiazolin-3-one + 2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 % E0115

23

Mercaptobenzothiazole

2

% E1010

Sesquiterpene Lactone Mix

0.1

% E2459

24

(Alantolactone, Dehydrocostunolide, Costunolide; 0.033 % each)

25

Tixocortol pivalate

1

% E2940

26

Dibromodicyanobutane

0. 3

% E2516

27

Hydroxymethylpentylcyclohexenecarboxaldehyde

5

% E2824

Primin

0.01 % E0032

28

(important only in some countries)

Remarks The single ingredients of the Thiuram Mix and the Mercapto Mix are listed under Rubber Chemicals, page 35, the Paraben Mix ingredients are listed under Preservatives, page 34, and the constituents of the Fragrance Mix / Fragrance Mix II are listed under Perfumes, Flavours, pages 29-31. Serial No. 1 Potassium Dichromate: slightly irritant; when relevance is in doubt, retest at 0.25 % (E2506 p. 38). Serial No. 19 Fragrance Mix: contains the emulsifier Sorbitan Sesquioleate (E1703). Serial No. 20 Quaternium-15: formaldehyde releaser.

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Serial No.

Substance

Concentration

Control irritant

Art. No.

IR

Sodiumlaurylsulfate (SLS) (in water)

0.25

Antioxidants

% E2893

AO

1

Butyl Hydroxytoluene

2

% E0110

2

Butyl Hydroxyanisole

2

% E0111

3

Dodecyl Gallate (Lauryl Gallate)

0.3

% E2496

4

tert.-Butylhydroquinone

1

% E2434

5

Propyl Gallate

0.5

% E2497

6

Octyl Gallate

0.3

% E2495

Bakery Allergens 1

Vanillin

2

BA 10

% E1310

Eugenol *

1

% E1302

3

Isoeugenol *

1

% E1306

4

Sodium Benzoate

5

% E2385

5

Butyl Hydroxytoluene

2

% E0110

6

Menthol

1

% E2304

7

Cinnamyl Alcohol *

1

% E1300

8

Cinnamaldehyde *

1

% E1301

9

Butyl Hydroxyanisole

2

% E0111

10

Sorbic Acid

2

% E0113

11

Octyl Gallate

0.3

% E2495

12

Dipentene (dl-Limonene)

2

% E2000

13

Propyl Gallate

0.5

% E2497

14

Dodecyl Gallate (Lauryl Gallate)

0.3

% E2496

* Ingredients of the Fragrance Mix (E0029) 19


Serial No.

Substance

Concentration

Cosmetics

Art. No.

COS

1

Hydroquinone

1

% E0800

2

Toluenesulphonamide Formaldehyde Resin 10

% E0908

3

Abitol

10

% E0915

4

Benzyl Salicylate

1

% E1102

5

Vanillin

10

% E1310

6

Lemon Grass Oil

2

% E1355

7

Balsam of Tolu

20

% E1652

8

Cocamidopropylbetaine (in water)

1

% E2303

9

Abietic Acid

10

% E2382

10

Sodium Benzoate

5

% E2385

11

Benzyl Alcohol

1

% E2388

12

Dexpanthenol

5

% E2387

13

Sodium Metabisulfite

1

% E2412

14

Benzophenone 4

10

% E2500

Remarks The following series should be tested in addition: Baseline Series • Antioxidants • Preservatives • Disinfectants • Sunscreen Agents • Vehicles, Emulsifiers • Hairdressing series (in case of head and neck eczema).

20


Serial No.

Substance

Concentration

Cutting oils I (current)

Art. No.

CO I

1

7-Ethylbicyclooxazolidine *

1

% E2422

2

1,3,5-Tris(2-hydroxyethyl)hexahydrotriazine

1

% E0119

3

Triclosan

2

% E0158

4

Benzotriazole

1

% E0159

5

Benzylhemiformal *

1

% E2450

6

Trolamine (Triethanolamine)

2.5

% E1701

7

Monoethanolamine

2

% E2445

8

Abietic Acid

10

% E2382

9

Diethanolamine

2

% E2401

10

Octylisothiazolinone

0.025 % E2427

11

Methylene-bis(methyloxazolidine) *

1

% E2452

12

Paratertiary Butylphenol

1

% E0920

13

Di-n-Butylphthalate

5

% E0903

14

Di-2-Ethylhexyl-Phthalate

5

% E0960

15

Tricresyl Phosphate (isomere blend)

5

% E2511

16

Polyethylene Glycol Ointment

100

% E2337

17

Isopropyl Myristate

10

% E2336

18

Adeps lanae

30

% E2335

19

Propyleneglycol

5

% E2323

20

Butyl Hydroxytoluene

2

% E0110

21

Phenoxyethanol

1

% E2392

22

tert.-Butylhydroquinone

1

% E2434

23

Cetyl/Stearyl Alcohol

20

% E1704

24

Bis(diethyldithiocarbamato) Zinc

1

% E1009

25

1,2-Benzisothiazolin-3-one, Na-Salt

0.1

% E2471

21


Serial No.

Substance

Concentration

Art. No.

CO I

Cutting oils I (current) continued 26

Diglycolamine

1

% E2884

27

Iodopropynyl Butylcarbamate

0. 2

% E2883

Remarks to Cutting oils I (current) Further substances currently used in cutting oils are included in the Baseline Series: E0020, E0017, E1010, E0004, E0115. Serial No. 19 Propyleneglycol: retesting at 20 % in water (E2472) can be necessary. Serial No. 21 Phenoxyethanol: content of Dibromodicyanobutane/ Phenoxyethanol (1:4) (E2515) * formaldehyde releaser.

Cutting oils II (historical)

CO II

1

Chloroxylenol

1

% E0106

2

Chloracetamide

0.2

% E0117

3

Dipentene (dl-Limonene)

2

% E2000

4

Coconut Diethanolamide

0.5

% E2424

5

Nitrobutylmorpholine / Ethylnitrotrimethylenedimorpholine *

1

% E2426

6

Dibromodicyanobutane

0.2

% E2939

7

Hexamethylenetetramine

1

% E2318

8

Chlorocresol

1

% E0105

9

Morpholinylmercaptobenzothiazole

0.5

% E1015

10

Ethylenediamine Dihydrochloride

1

% E0027

11

Bronopol *

0.5

% E0107

Remarks Further substances used in the past in cutting oils are included in the Baseline Series: E0008, E2469, E0029. Serial No. 6 Dibromodicyanobutane: content of Dibromodicyanobutane/ Phenoxyethanol (1:4) (E2515) * formaldehyde releaser.

22


Serial No.

Substance

Concentration

Dental Materials

Art. No.

DM

1

Menthol

1

% E2304

2

Peppermint Oil

2

% E1358

3

Benzoyl Peroxide

1

% E0201

4

Hydroquinone

1

% E0800

5

Bisphenol A

1

% E0965

6

Methyl Methacrylate

2

% E1800

7

N,N-Dimethyl-p-Toluidine

2

% E0963

8

Ethyleneglycol Dimethacrylate

2

% E1850

9

Triethyleneglycol Dimethacrylate

2

% E1851

10

BIS-GMA

2

% E1852

11

Diurethane Dimethacrylate

2

% E2475

12

(2-Hydroxyethyl) Methacrylate (2-HEMA) 1

% E2477

13

Eugenol

1

% E1302

14

Ammoniated Mercury

1

% E0602

15

Potassium Dicyanoaurate (in water)

0.002 % E0605

16

Sodium Thiosulfatoaurate

0.25 % E2507

17

Palladium Chloride

1

18

Ammonium Tetrachloroplatinate

0.25 % E0650

19

Amalgam

5

% E2509

20

Amalgam Alloying Metals

20

% E2508

% E0651

Remarks Serial No. 3 Benzoyl Peroxide: slightly irritant; when relevance is in doubt, retest at 0.5 % or open testing. Serial No. 13 Eugenol: ingredient of the Fragrance Mix.

23


Serial No.

Substance

Concentration

Disinfectants

Art. No.

DIS

1

Chlorhexidine Digluconate (in water)

0.5

% E0114

2

Glutar(di)aldehyde

0.3

% E2498

3

Benzalkonium Chloride

0.1

% E2339

4

Cetylpyridinium Chloride

0.1

% E2315

5

Glyoxal Trimer (Dihydrate)

1

% E2517

6

Cetalkonium Chloride

0.1

% E2433

Epoxy Resin Systems

ERS

Reactive diluents 1

Cresylglycidylether

0.25 % E0917

2

Phenylglycidlyether

0.25 % E2807

3

Butylglycidylether

0.25 % E2808

4

1,6-Hexanedioldiglycidylether (techn. grade)

0.25

% E2876

5

1,4-Butanedioldiglycidylether

0.25

% E2875

6

p-tert-Butylphenylglycidylether

0.25

% E2880

Hardeners 7

Ethylenediamine Dihydrochloride

1

% E0027

8

Triethylenetetramine

0.5

% E0905

9

4,4’-Diaminodiphenyl Methane

0.5

% E0906

10

Isophoronediamine

0.5

% E0914

11

Hexamethylenetetramine

1

% E2318

12

Trimethylhexane-1,6-diamine (isomere blend)

0. 5

% E2946

24


Serial No.

Substance

Concentration

Hairdressing

Art. No.

HD

1

4-Toluenediamine (dye complex)

1

% E0308

2

Glyceryl Monothioglycolate

1

% E0311

3

Monoethanolamine

2

% E2445

4

Ammonium Persulphate

2.5

%

5

4-Aminophenol

1

% E2302

6

3-Aminophenol

1

% E2301

7

Cocamidopropylbetaine (in water)

1

% E2303

8

Hydroquinone

1

% E0800

9

Resorcinol

1

% E2865

E0306

Remark Serial No. 4 Ammonium Persulphate: Caution: This allergen might elicit a Type I reaction.

Industrial Biocides

IB

1

7-Ethylbicyclooxazolidine *

1

% E2422

2

Chloroxylenol

1

% E0106

3

Chloracetamide

0.2

% E0117

4

1,3,5-Tris(2-hydroxyethyl)hexahydrotriazine *

1

% E0119

5

Triclosan

2

% E0158

6

Benzylhemiformal *

1

% E2450

7

Nitrobutylmorpholine / Ethylnitrotrimethylenedimorpholine *

1

% E2426

8

Octylisothiazolinone

0.025 % E2427

9

Methylene-bis(methyloxazolidine) *

1

% E2452

10

Dibromodicyanobutane

0.2

% E2939

11

1,2-Benzisothiazolin-3-one, Na-Salt

0.1

% E2471

25


Serial No.

Substance

Concentration

Art. No.

IB

Industrial Biocides continued 12

Chlorocresol

1

% E0105

13

Benzotriazole

1

% E0159

14

Iodopropynyl Butylcarbamate

0.2

% E2883

15

Methylisothiazolinone (in water)

0.05 % E2950

Remarks Serial No. 10 Dibromodicyanobutane: content of Dibromodicyanobutane/ Phenoxyethanol (1:4) (E2515). * formaldehyde releaser.

Medicaments I - Antibiotics 1

Bacitracin

2

Chloramphenicol

3

ME I 20

% E2151

5

% E2152

Gentamycin Sulphate

20

% E2154

4

Kanamycin Sulphate

10

% E2313

5

Tetracycline Hydrochloride

2

% E2306

6

Sulfanilamide

5

% E2160

7

Erythromycin

1

% E2499

8

Oxytetracycline

3

% E2416

9

Framycetin Sulphate

10

% E2311

Medicaments II Antiseptics, Antimycotics

ME II

1

Nystatin

2

% E2491

2

Chlorquinaldol

5

% E0104

3

Fusidic Acid Sodium Salt

2

% E2454

4

Clotrimazole

5

% E2389

5

Dichlorophene

0.5

% E2316

26


Serial No.

Substance

Concentration

Medicaments III - Miscellaneous

Art. No.

ME III

1

Benzoyl Peroxide

1

% E0201

2

Ethylenediamine Dihydrochloride

1

% E0027

3

Bufexamac

5

% E2395

4

Propolis

10

% E1207

5

Resorcinol

1

% E2865

Remark Serial No. 1 Benzoyl Peroxide: slightly irritant; when relevance is in doubt, retest at 0.5 % or open testing.

Medicaments IV Local Anaesthetics

ME IV

1

Cinchocaine Hydrochloride

5

% E0401

2

Tetracaine (Amethocaine) Hydrochloride 1

% E0402

3

Lidocaine Hydrochloride

15

% E0403

4

Polidocanol

3

% E2501

5

Procaine Hydrochloride

2

% E2308

Medicaments V - Corticosteroids

ME V

1

Amcinonide

0.1

% E2481

2

Betamethasone-17-valerate

0.12 % E2482

3

Clobetasol-17-propionate

0.25 % E2483

4

Hydrocortisone

1

% E2484

5

Hydrocortisone-17-butyrate

0.1

% E2485

6

Triamcinolone Acetonide

0.1

% E2486

7

Prednisolone

1

% E2505

Remark Corticosteroids: Rebound effect; late readings at 72 h or later for clinical relevance.

27


Serial No.

Substance

Concentration

Medicaments VI - Ophthalmics

Art. No.

ME VI

1

Atropine Sulfate (in water)

1

% E2415

2

Edetic Acid Disodium Salt

1

% E2384

3

Phenylephrine Hydrochloride (in water) 10

% E2414

4

Pilocarpine Hydrochloride (in water)

1

% E2407

5

Polymyxin B Sulfate

3

% E2437

Metal Compounds

MC

1

Ammoniated Mercury

1

% E0602

2

Potassium Dicyanoaurate (in water)

0.002 %

3

Sodium Thiosulfatoaurate

0.25 % E2507

4

Ammonium Tetrachloroplatinate

0.25 % E0650

5

Palladium Chloride

1

% E0651

6

Copper Sulphate, 5H2O (in water)

1

% E0604

7

Tin (II)-chloride

0.5

% E2419

E0605

Remark Serial No. 5 Palladium Chloride: cross-reacting especially with Nickel.

Methacrylates

MA

1

(2-Hydroxyethyl) Methacrylate (2-HEMA) 1

% E2477

2

Methyl Methacrylate

2

% E1800

3

Ethyleneglycol Dimethacrylate

2

% E1850

4

Triethyleneglycol Dimethacrylate

2

% E1851

5

BIS-GMA

2

% E1852

6

Diurethane Dimethacrylate

2

% E2475

7

Hydroquinone

1

% E0800

28


Serial No.

Substance

Concentration

Art. No.

MA

Methacrylates continued 8

N,N-Dimethyl-p-Toluidine

2

% E0963

9

Benzoyl Peroxide

1

% E0201

Remark Serial No. 9 Benzoyl Peroxide: slightly irritant; when relevance is in doubt, retest at 0.5 % or open testing.

Perfumes, Flavours

PF

1

Benzyl Salicylate

1

%

E1102

2

Benzylcinnamate

5

% E1351

3

Salicylaldehyde

2

% E1359

4

Vanillin

10

% E1310

5

Benzyl Alcohol

1

% E2388

6

Benzaldehyde

5

% E1350

7

Menthol

1

% E2304

8

Dipentene (dl-Limonene)

2

% E2000

9

Gamma Methyl Ionone

1

% E2886

10

Anisyl Alcohol

1

% E2887

11

alpha-Amylcinnamyl Alcohol

1

% E2888

12

Benzyl Benzoate

1

% E2889

13

Lilial

10

% E2892

14

Linalool (stabilized)

10

% E2930

15

Methyl Heptine Carbonate

1

% E2933

16

Majantol

5

% E2885

Essential Oils / Extracts 17

Tree Moss

1

% E2947

18

Clove Oil

2

% E1308

19

Orange Oil

2

% E1309

29


Serial No.

Substance

Concentration

Art. No.

PF

Perfumes, Flavours continued 20

Cedarwood Oil

10

% E1352

21

Eucalyptus Oil

2

% E1353

22

Laurel Leaf Oil

2

% E1354

23

Lemon Grass Oil

2

% E1355

24

Lemon Oil

2

% E1356

25

Neroli Oil

2

% E1357

26

Peppermint Oil

2

% E1358

27

Ylang-ylang (I+II)-Oil

10

% E2891

28

Narcissus absolute

2

% E2934

29

Jasmin absolute

5

% E2935

30

Sandalwood oil

10

% E2936

31

Patchouli oil

10

% E2937

Constituents of the Fragrance Mix 8% in pet (E0029) 32

Cinnamyl Alcohol

1

% E1300

33

Cinnamaldehyde

1

% E1301

34

Eugenol

1

% E1302

35

alpha-Amyl-Cinnmaldehyde

1

% E1303

36

Hydroxycitronellal

1

% E1304

37

Geraniol

1

% E1305

38

Isoeugenol

1

% E1306

39

Oak Moss Absolute

1

% E1307

40

Sorbitan Sesquioleate

20

% E1703

Constituents of the Fragrance Mix II 14% in pet (E2860) 41

Citral

2

% E2839

42

Citronellol

1

% E2842

43

Farnesol

5

% E2848

30


Serial No.

Substance

Concentration

PF

Perfumes, Flavours continued 44

Coumarin

45

alpha-Hexyl cinnamaldehyde

Art. No.

5

% E2845

10

% E2836

Hydroxymethylpentylcyclohexenecarboxaldehyde (Lyral ®) is part of the Fragrance Mix II. Lyral ® is not included in this test series as Lyral ® is already tested in the Baseline Series 5

% E2824

Remark Serial Nos. 32-39 contain the emulsifier Sorbitan Sesquioleate (E1703).

Photoallergens

PA

1

5-Bromo-4’-chlorosalicylanilide

1

% E2354

2

Hexachlorophene

1

% E0101

3

Bithionol

1

% E0100

4

Sulfanilamide

5

% E2160

5

Promethazine Hydrochloride

0.1

% E2356

6

Quinidine Sulphate

1

% E2358

7

Fragrance Mix

8

% E0029

8

4-Aminobenzoic Acid (PABA)*

10

% E2359

9

2-Ethylhexyl-4-Dimethylaminobenzoate* 10

% E2365

10

Benzophenone 4 *

10

% E2500

11

4-tert-Butyl-4’-MethoxyDibenzoylmethane *

10

% E2364

12

Isoamyl-4-methoxycinnamate *

10

% E2368

13

2-Ethylhexyl-4-Methoxycinnamate * 10

% E2366

14

3-(4-Methylbenzylidene)-Camphor * 10

% E2362

15

2-Phenyl-5-benzimidazole-Sulphonic Acid* 10

% E2367

Oxybenzone *

% E2361

16

10 31


Serial No.

Substance

Concentration

Art. No.

Remarks Photoallergens have to be patch tested in duplicate; one series is irradiated with 5 to 10 J UV-A. * Sunscreen Agents. Serial No. 7 Fragrance Mix: the single constituants are listed under Perfumes, Flavours, pages 29-31.

Photographic Chemicals

PC

1

Ammonium Persulphate

2

4-Methylaminophenol Sulphate (Metol) 1

% E0801

3

Color Developer CD 2

1

% E0803

4

Color Developer CD 3

1

% E0804

5

Color Developer CD 4

1

% E0806

6

Pyrogallol

1

% E0350

7

4-Aminophenol

1

% E2302

8

Hydroquinone

1

% E0800

9

Triphenyl Phosphate

5

% E0959

10

Trolamine (Triethanolamine)

2.5

% E1701

11

Edetic Acid Disodium Salt

1

% E2384

12

Diethanolamine

2

% E2401

13

Sodium Metabisulfite

1

% E2412

14

Glutar(di)aldehyde

0.3

% E2498

32

2.5

% E0306


Serial No.

Substance

Concentration

Plants

Art. No.

PL

1

Dipentene (dl-Limonene)

2

% E2000

2

Usnic Acid

0.1

% E2052

Plastic Materials

PM

1

Phenol Formaldehyde Resin, Novolac * 5

% E0901

2

Abitol®

10

% E0915

3

Turpentine Oil

10

% E2322

4

Parateriary Butylphenol

1

% E0920

5

Di-n-Butylphthalate

5

% E0903

6

Tricresyl Phosphate

5

% E2511

7

Triphenyl Phosphate

5

% E0959

8

Dimethylphthalate

5

% E0954

9

Di-2-Ethylhexyl-Phthalate

5

% E0960

10

Bisphenol A

1

% E0965

11

Abietic Acid

10

% E2382

12

4-tert.-Butylcatechol

0.25 % E2810

Remark * Patch testing of the patient’s own resin is recommended.

33


Serial No.

Substance

Concentration

Preservatives

Art. No.

PR

1

Chlorocresol

1

% E0105

2

Chloroxylenol

1

% E0106

3

Bronopol **

0.5

% E0107

4

Imidazolidinyl Urea **

2

% E0109

5

Phenylmercuric Acetate

0.01 % E2863

6

Sorbic Acid

2

% E0113

7

Chloracetamide

0.2

% E0117

8

Thiomersal

0.1

% E0600

9

Chlorquinaldol

5

% E0104

10

Triclosan

2

% E0158

11

Diazolidinyl Urea **

2

% E2386

12

Dibromodicyanobutane/ Phenoxyethanol (1:4)

1

% E2515

13

DMDM Hydantoin (in water) **

2

% E2476

14

Phenoxyethanol *

1

% E2392

15

Sodium Metabisulfite

1

% E2412

16

Dibromodicyanobutane *

0.2

% E2939

17

Iodopropynyl Butylcarbamate

0.2

% E2883

18

Methylisothiazolinone (in water)

0.05 % E2950

Constituents of the Paraben Mix 19

Methyl Parahydroxybenzoate

3

% E0151

20

Ethyl Parahydroxybenzoate

3

% E0152

21

Propyl Parahydroxybenzoate

3

% E0153

22

Butyl Parahydroxybenzoate

3

% E0154

Remarks * content of Dibromodicyanobutane/Phenoxyethanol (1:4) (E2515). ** formaldehyde releaser.

34


Serial No.

Substance

Concentration

Rubber Chemical

Art. No.

RC

1

Hexamethylenetetramine

1

% E2318

2

Diphenylthiourea

1

% E1021

3

Dibutylthiourea

1

% E1025

4

1,3-Diphenylguanidine

1

% E1002

5

Bis(diethyldithiocarbamato) Zinc

1

% E1009

6

N,N’-Diphenyl Paraphenylenediamine 0.25 % E1013

7

Bis(dibutyldithiocarbamato) Zinc

1

% E1019

8

Cyclohexyl Thiophthalimide

0.5

% E2805

9

4,4’-Dihydroxybiphenyl

0.1

% E1005

10

Zinc dibenzyldithiocarbamate

1

% E2864

11

4-tert.-Butylcatechol

0.25 % E2810

Constituents of the Thiuram Mix 12

Tetramethylthiuram Disulphide

0.25 % E1011

13

Tetraethylthiuram Disulphide

0.25 % E1016

14

Tetramethylthiuram Monosulphide

0.25 % E1008

15

Dipentamethylenethiuram Disulphide

0.25 % E1017

Constituents of the Mercapto Mix 16

Dibenzothiazyl Disulphide

1

% E1014

17

N-Cyclohexylbenzothiazyl Sulphenamide 1

% E1000

18

Morpholinylmercaptobenzothiazole

% E1015

35

0.5


Serial No.

Substance

Concentration

Shoe Allergens

Art. No.

SH

1

Glutar(di)aldehyde

0.3

% E2498

2

Disperse Orange 3

1

% E0502

3

Acid Yellow 36

1

% E2403

4

Monobenzone

1

% E1001

5

Diphenylthiourea

1

% E1021

6

1,3-Diphenylguanidine

1

% E1002

7

Dibutylthiourea

1

% E1025

8

Octylisothiazolinone

0.025 % E2427

Sunscreen Agents

SA

1

2-Phenyl-5-benzimidazole-Sulphonic 10 Acid

% E2367

2

4-tert-Butyl-4’Methoxy-Dibenzoylmethane

10

% E2364

3

4-Aminobenzoic Acid (PABA)

10

% E2359

4

2-Ethylhexyl4-Dimethylaminobenzoate

10

% E2365

5

2-Ethylhexyl-4-Methoxycinnamate

10

% E2366

6

3-(4-Methylbenzylidene)-Camphor

10

% E2362

7

Oxybenzone

10

% E2361

8

Isoamyl-4-methoxycinnamate

10

% E2368

9

Benzophenone 4

10

% E2500

Remark Sunscreen Agents might also elicit photoallergic reactions.

36


Serial No.

Substance

Concentration

Textile and Leather Dyes

Art. No.

TD

1

Disperse Orange 3

1

% E0502

2

Disperse Yellow 3

1

% E0503

3

Disperse Red 1

1

% E0504

4

Disperse Red 17

1

% E0505

5

Disperse Blue 3

1

% E0506

6

Disperse Red 11

1

% E2478

7

Disperse Yellow 9

1

% E2479

8

Naphthol AS

1

% E2474

9

4-Aminophenol

1

% E2302

10

Acid Yellow 36

1

% E2403

11

Bismarck Brown R

0.5

% E2428

12

Disperse blue 106

0.3

% E2948

13

Disperse blue 124

0.3

% E2949

Remark Serial No. 8 Naphthol AS: dye coupler.

Vehicles, Emulsifiers

VE

1

Trolamine (Triethanolamine)

2.5

% E1701

2

Propyleneglycol

5

% E2323

3

Sorbitan Sesquioleate

20

% E1703

4

Cetyl/Stearyl Alcohol

20

% E1704

5

Amerchol L 101

50

% E1750

6

Polyethylene Glycol Ointment

100

% E2337

7

Isopropyl Myristate

10

% E2336

8

Adeps lanae

30

% E2335

9

Coconut Diethanolamide 37

0.5

% E2424


Serial No.

Substance

Concentration

Art. No.

Remarks Serial No. 2 Propyleneglycol: retesting at 20 % in water (E2472) can be necessary. Serial No. 3 Sorbitan Sesquioleate: as emulsifier used in Fragrance Mix and in the single ingredients of the Fragrance Mix. Serial No. 6 Polyethylene Glycol Ointment: 1:1 mixture of Polyethylene Glycol 300 & 1500.

Miscellaneous

MIC

1

Hexylresorcinol

0.25 % E0312

2

Potassium Dichromate

0.25 % E2506

3

Propyleneglycol (in water)

4

White Petrolatum

5

4-Aminoazobenzene

20

% E2472

100

% E8999

1

% E2435

Service Items 1

Empty service and storage box for 12 substances with 1 blank drawer insert

D9100

Empty service and storage box for 24 substances with 2 blank drawer inserts

E9101

Empty service and storage box for 36 substances with 3 blank drawer inserts

D9229

Empty service and storage box for 60 substances with 5 blank drawer inserts

D9102

5

Blank drawer inserts for service and storage box

D9112

6

Patient's test sheet

E9104

7

TROLAB速 Brochure

E9105

2 3 4

38


International Standard Series of Patch Testing Proposed allergens for a modified international standard series by the International Contact Dermatitis Research Group - ICDRG. Contact Dermatitis 1997, 36, 121-123 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) 15) 16) 17) 18) 19) 20)

Potassium Dichromate Neomycine Sulfate Thiuram Mix Parapheneylendiamine (PPD) base Formaldehyde Colophony Balsam of Peru Wool (lanolin) Alcohols Mercapto Mix Epoxy Resin Paratertiarybutyl Phenol Formaldehyde (BPF) Resin Fragrance Mix Nickel Sulfate (NiSO4 路 6H2O) Mercaptobenzothiazole (MBT) Budesonide Quaternium 15 Cl + Me-isothiazolinone Imidazolidinyl Urea Tixocortol Pivalate Dibromodicyanobutane

0.5 20 1 1 1 20 25 30 1 1 1 8 2.5 1 0.1 2 0.01 2 1 0.1

% % %a %b % aq. % % % %c % % %d %1 %e %f %g % aq.h % aq. % %i

Statements given by the ICDRG: a) Thiuram Mix lacks high specificity and sensitivity b) Some cases of hair dye dermatitis could be missed with the use of PPD alone. c) Mercapto Mix lacks high specificity and sensitivity. The 1% mix, used in the North American standard series, is chosen since its stability has been proven by Hermal and approved by the FDA. d) If positive, breakdown is needed. e) MBT can identify cases of allergic contact dermatitis negative to Mercapto Mix, and vice versa. f) Despite its absence in 3 standard series, Budesonide is highly recommended in an international standard series, since it is considered an important marker for corticosteroid allergy. g) It is an important allergen in the United Kingdom, while it is not used in Japan. h) Mainly used in Japan. i) Syn: 1,2-dibromo-2,4-dicyanobutane; methyldibromoglutaronile. Present in Euxyl 庐 K 400 (dibromodicyanobutane + phenoxyethanol 1:4)

39


Comments by Almirall to this proposal: 1. Nickel Sulphate is in the North American Standard Series 2,5 % as the waterfree salt; in Europe the NiS04 路 6H2O salt 5 % is approved by the authorities. The molecular content of nickel ions of both test allergens is almost equal. Testing NiS04 路 6H2O at 2,5 % as proposed by the ICDRG means testing only 50 % of the Nickel content that is being tested in Europe and North America.

40


List of test substances Substance / Synonyms

Concentration

A Abietic Acid Abitol速 Acid Yellow 36 Adeps lanae alpha-Amyl-Cinnamaldehyde alpha-Amylcinnamyl Alcohol Amalgam Amalgam Alloying Metals Amcinonide Amethocaine see Tetracaine Hydrochloride Amerchol速 L 101 4-Aminoazobenzene 4-Aminobenzoic Acid (PABA) 3-Aminophenol 4-Aminophenol m-Aminophenol see 3-Aminophenol p-Aminophenol see 4-Aminophenol Ammoniated Mercury Ammonium Persulphate Ammonium Tetrachloroplatinate Anisyl Alcohol Atropine Sulfate (in water) B Bacitracin Balsam of Peru Balsam of Tolu Benzaldehyde Benzalkonium Chloride 1,2-Benzisothiazolin-3-one, Na-Salt Benzocaine Benzophenone 3 see Oxybenzone Benzophenone 4 Benzotriazole Benzoyl Peroxide Benzyl Alcohol Benzyl Benzoate Benzylcinnamate Benzylhemiformal Benzyl Salicylate Betamethasone-17-valerate BHA see Butyl Hydroxyanisole BHT see Butyl Hydroxytoluene Bioban速 CS-1246 see 7-Ethylbicyclooxazolidine

41

10 10 1 30 1 1 5 20 0.1 1 50 1 10 1 1 1 1 1 2.5 0.25 1 1 20 25 20 5 0.1 0.1 5 10 10 1 1 1 1 5 1 1 0.12 2 2 1

Art. No.

Series

% % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % %

E2382 COS, CO I, PM E0915 COS, PM E2403 SH, TD E2335 CO I, VE E1303 PF E2888 PF E2509 DM E2508 DM E2481 ME V E0402 ME IV E1750 VE E2435 MIC E2359 PA, SA E2301 HD E2302 HD, PC, TD E2301 HD E2302 HD, PC, TD E0602 DM, MC E0306 HD, PC E0650 DM, MC E2887 PF E2415 ME VI E2151 ME I E0008 BS E1652 COS E1350 PF E2339 DIS E2471 CO I, IB E0011 BS E2361 PA, SA E2500 PA, SA, COS E0159 CO I, IB E0201 DM, ME III, MA E2388 COS, PF E2889 PF E1351 PF E2450 CO I, IB E1102 COS, PF E2482 ME V E0111 AO, BA E0110 AO, BA, CO I

%

E2422

CO I, IB


Substance / Synonyms

Concentration

Bioban® P 1487 see Nitrobutylmorpholine/ Ethylnitrotrimethylenedimorpholine 1 Bis(dibutyldithiocarbamato) Zinc 1 Bis(diethyldithiocarbamato) Zinc 1 BIS-GMA 2 Bismarck Brown R 0.5 Bisphenol A 1 Bithionol 1 BPF-Resin see Paratertiarybutyl Phenol Formaldehyde Resin 1 5-Bromo-4’-chlorosalicylanilide 1 2-Bromo-2-nitropropane-1,3-diol see Bronopol 0.5 Bronopol 0.5 Budesonide 0.1 Bufexamac 5 1,4-Butanedioldiglycidylether 0.25 4-tert.-Butylcatechol 0.25 Butylglycidylether 0.25 tert.-Butylhydroquinone 1 Butyl Hydroxyanisole 2 Butyl Hydroxytoluene 2 4-tert-Butyl-4’-Methoxy-Dibenzoylmethane 10 Butyl Paraben see Butyl Parahydroxybenzoate 3 Butyl Parahydroxybenzoate 3 p-tert Butylphenylglycidylether 0.25 Di-n-Butylphthalate 5 C CBS see N-Cyclohexylbenzothiazyl Sulphenamide 1 Cedarwood Oil 10 Cetalkonium Chloride 0.1 Cetearylalcohol see Cetyl/Stearyl Alcohol 20 Cetylpyridinium Chloride 0.1 Cetyl/Stearyl Alcohol 20 Chinoform see Clioquinol 5 Chloracetamide 0.2 Chloramphenicol 5 Chlorhexidine Digluconate (in water) 0.5 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane Chloride see Quaternium-15 1 Chlorocresol 1 5-Chloro-2-methyl-4-isothiazolin-3-one + 2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 Chloroxylenol 1 Chlorquinaldol 5 Cinchocaine Hydrochloride 5

42

Art. No.

Series

% % % % % % %

E2426 E1019 E1009 E1852 E2428 E0965 E0100

CO II, IB RC CO I, RC DM, MA TD DM, PM PA

% %

E0030 E2354

BS PA

% % % % % % % % % % % % % % %

E0107 E0107 E2504 E2395 E2875 E2810 E2808 E2434 E0111 E0110 E2364 E0154 E0154 E2880 E0903

CO II, PR CO II, PR BS ME III ERS PM, RC ERS AO, CO I AO, BA AO, BA, CO I PA, SA PR PR ERS CO I, PM

% % % % % % % % % %

E1000 E1352 E2433 E1704 E2315 E1704 E0015 E0117 E2152 E0114

RC PF DIS CO I, VE DIS CO I, VE BS CO II, IB, PR ME I DIS

% %

E0031 E0105

BS CO II, IB, PR

% % % %

E0115 E0106 E0104 E0401

BS CO II, IB, PR ME II, PR ME IV


Substance / Synonyms

Concentration

Cinnamal see Cinnamaldehyde 1 Cinnamaldehyde 1 Cinnamyl Alcohol 1 Citral 2 Citronellol 1 Clioquinol 5 Clobetasol-17-propionate 0.25 Clotrimazole 5 Clove Oil 2 Cobalt Chloride, 6H2O 1 Cocamide DEA see Coconut Diethanolamide 0.5 Cocamidopropylbetaine (in water) 1 Coconut Diethanolamide 0.5 Colophony 20 Color Developer CD 2 1 Color Developer CD 3 1 Color Developer CD 4 1 Copper Sulphate, 5H2O (in water) 1 Coumarin 5 Cresylglycidylether 0.25 N-Cyclohexylbenzothiazyl Sulphenamide 1 Cyclohexyl Thiophthalimide 0.5 D Dexpanthenol 5 4,4’-Diaminodiphenyl Methane 0.5 Diazolidinyl Urea 2 Dibenzothiazyl Disulphide 1 Dibromodicyanobutane 0.2 Dibromodicyanobutane 0.3 Dibromodicyanobutane/Phenoxyethanol (1:4) 1 Di-n-Butylphthalate 5 Dibutylthiourea 1 Dichlorophene 0.5 Diethanolamine 2 Di-2-Ethylhexyl-Phthalate 5 Diglycolamine 1 4,4’-Dihydroxybiphenyl 0.1 Dimethylphthalate 5 N,N-Dimethyl-p-Toluidine 2 Dipentamethylenethiuram Disulphide 0.25 Dipentene (dl-Limonene) 2 1,3-Diphenylguanidine 1 N,N’-Diphenyl Paraphenylenediamine 0.25 Diphenylthiourea 1 Disodium EDTA see Edetic Acid Disodium Salt 1 Disperse Blue 3 1

43

Art. No.

Series

% % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % %

E1301 BA, PF E1301 BA, PF E1300 BA, PF E2839 PF E2842 PF E0015 BS E2483 ME V E2389 ME II E1308 PF E0002 BS E2424 CO II E2303 COS, HD E2424 CO II, VE E0017 BS E0803 PC E0804 PC E0806 PC E0604 MC E2845 PF E0917 ERS E1000 RC E2805 RC E2387 COS E0906 ERS E2386 PR E1014 RC E2939 CO II, IB, PR E2516 BS E2515 PR E0903 CO I, PM E1025 RC, SH E2316 ME II E2401 CO I, PC E0960 CO I, PM E2884 CO I E1005 RC E0954 PM E0963 DM, MA E1017 RC E2000 BA, CO II, PF, PL E1002 RC, SH E1013 RC E1021 RC, SH

% %

E2384 E0506

ME VI, PC TD


Substance / Synonyms

Concentration

Disperse blue 106 0.3 Disperse blue 124 0.3 Disperse Orange 3 1 Disperse Red 1 1 Disperse Red 11 1 Disperse Red 17 1 Disperse Yellow 3 1 Disperse Yellow 9 1 Diurethane Dimethacrylate 2 DMDM Hydantoin (in water) 2 Dodecyl Gallate (Lauryl Gallate) 0.3 DPG see 1,3-Diphenylguanidine 1 E Edetic Acid Disodium Salt 1 EGDMA see Ethyleneglycol Dimethacrylate 2 Epoxy Resin 1 Erythromycin 1 Escalol® 507 see 2-Ethylhexyl-4-Dimethylaminobenzoate 10 Ethanolamine see Monoethanolamine 2 7-Ethylbicyclooxazolidine 1 Ethylenediamine Dihydrochloride 1 Ethyleneglycol Dimethacrylate 2 2-Ethylhexyl-4-Dimethylaminobenzoate 10 2-Ethylhexyl-4-Methoxycinnamate 10 Ethyl Paraben see Ethyl Parahydroxybenzoate 3 Ethyl Parahydroxybenzoate 3 Eucalyptus Oil 2 Eugenol 1 Eusolex® 232 see 2-Phenyl-5-benzimidazol-sulphonic Acid 10 Eusolex® 4360 see Oxybenzone 10 Eusolex® 6300 see 3-(4-Methylbenzylidene)-Camphor 10 Euxyl® K400 see Dibromodicyanobutane/Phenoxyethanol (1:4) 1 F Farnesol 5 Formaldehyde (in water) 1 Fragrance Mix 8 Fragrance Mix II 14 Framycetin Sulphate 10 Fusidic Acid Sodium Salt 2 G Gamma Methyl Ionone 1 Gentamycin Sulphate 20 Geraniol 1 Germall II see Diazolidinyl Urea 2 Germall 115 see Imidazolidinyl Urea 2

44

Art. No.

Series

% % % % % % % % % % % % % % % %

E2948 E2949 E0502 E0504 E2478 E0505 E0503 E2479 E2475 E2476 E2496 E1002 E2384 E1850 E0021 E2499

TD TD SH, TD TD TD TD TD TD DM, MA PR AO, BA RC, SH ME VI, PC DM, MA BS ME I

% % % % % % % % % % %

E2365 PA, SA E2445 CO I, HD E2422 CO I, IB E0027 CO II, ERS, ME III E1850 DM, MA E2365 PA, SA E2366 PA, SA E0152 PR E0152 PR E1353 PF E1302 BA, DM, PF

% %

E2367 E2361

PA, SA PA, SA

%

E2362

PA, SA

% % % % % % % % % % % %

E2515 E2848 E0004 E0029 E2860 E2311 E2454 E2886 E2154 E1305 E2386 E0109

PR PF BS BS, PA BS ME I ME II PF ME I PF PR PR


Substance / Synonyms

Concentration

Glutar(di)aldehyde Glyceryl Monothioglycolate Glyceryl Thioglycolate see Glyceryl Monothioglycolate Glyoxal Trimer (Dihydrate) GTG see Glyceryl Monothioglycolate H 2-HEMA see (2-Hydroxyethyl) Methacrylate Hexachlorophene Hexamethylenetetramine 1,6-Hexanedioldiglycidylether (techn. grade) alpha-Hexyl cinnamaldehyde Hexylresorcinol Hydroabietyl Alcohol see Abitol® Hydrocortisone Hydrocortisone-17-butyrate Hydroquinone

Art. No.

Series

0.3 1

% %

E2498 E0311

DIS, PC, SH HD

1 1 1

% % %

E0311 E2517 E0311

HD DIS HD

1 1 1

% % %

E2477 E0101 E2318

DM, MA PA CO II, ERS, RC

0.25 10 0.25 10 1 0.1 1

% % % % % % %

E2876 E2836 E0312 E0915 E2484 E2485 E0800

Hydroxycitronellal 1 (2-Hydroxyethyl) Methacrylate (2-HEMA) 1 Hydroxymethylpentylcyclohexenecarboxaldehyde 5 I Imidazolidinyl Urea 2 Iodopropynyl Butylcarbamate 0.2 IPCB see Iodopropynyl butylcarbamate 0.2 IPPD see N-Isopropyl-N’-phenyl Paraphenylenediamine 0.1 Isoamyl-4-methoxycinnamate 10 Isoeugenol 1 Isophoronediamine 0.5 4,4’-Isopropylidenediphenol see Bisphenol A 1 Isopropyl Myristate 10 N-Isopropyl-N’-phenyl Paraphenylenediamine 0.1 J Jasmine absolute 5 K Kanamycin Sulphate 10 Kathon® CG see 5-Chloro-2-methyl-4-isothiazolin-3-one + 2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 Kovanol® see Hydroxymethylpentylcyclohexenecarboxaldehyde 5 L Laurel Leaf Oil 2 Lauryl Gallate see Dodecyl Gallate 0.3 Lemon Grass Oil 2

% %

E1304 E2477

ERS PF MIC COS, PM ME V ME V COS, DM, HD, PC, MA PF DM, MA

% % % %

E2824 E0109 E2883 E2883

BS PR CO I, IB, PR CO I, IB, PR

% % % %

E1004 E2368 E1306 E0914

BS PA, SA BA, PF ERS

% % % % %

E0965 E2336 E1004 E2935 E2313

DM, PM CO I, VE BS PF ME I

%

E0115

BS

% % % %

E2824 E1354 E2496 E1355

BS PF AO, BA COS, PF

45


Substance / Synonyms

Concentration

Lemon Oil 2 Lidocaine Hydrochloride 15 Lilial 10 dl-Limonene see Dipentene 2 Linalool (stabilized) 10 Lyral® see Hydroxymethylpentylcyclohexenecarboxaldehyde 5 M Majantol 5 m-Aminophenol see 3-Aminophenol 1 MBT see Mercaptobenzothiazole 2 MDBGN see Dibromodicyanobutane 0.3 Menthol 1 Mercaptobenzothiazole 2 Mercapto Mix 1 Methenamine see Hexamethylenetetramine 1 4-Methylaminophenol Sulphate 1 3-(4-Methylbenzylidene)-Camphor 10 Methylchloroisothiazolinone see 5-Chloro-2-methyl-4-isothiazolin-3-one + 2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 Methyldibromo glutaronitrile see Dibromodicyanobutane 0.3 Methylene-bis(methyloxazolidine) 1 Methyl Heptine Carbonate 1 Methylisothiazolinone (in water) 0.05 Methyl Methacrylate 2 Methyl Paraben see Methyl Parahydroxybenzoate 3 Methyl Parahydroxybenzoate 3 Metol see p-Methylaminophenol Sulphate (Metol) 1 Monobenzone 1 Monoethanolamine 2 Morpholinylmercaptobenzothiazole 0.5 N Naphthol AS 1 Narcissus absolute 2 N-Cyclohexylbenzothiazyl Sulphenamide 1 N,N-Dimethyl-p-Toluidine 2 N,N’-Diphenyl Paraphenylenediamine 0.25 Neomycin Sulphate 20 Neroli Oil 2 Nickel Sulphate, 6H2O 5 N-Isopropyl-N’-phenyl Paraphenylenediamine 0.1 Nitrobutylmorpholine/ Ethylnitrotrimethylenedimorpholine 1

46

Art. No.

Series

% % % % %

E1356 PF E0403 ME IV E2892 PF E2000 BA, CO II, PF, PL E2930 PF

% % % % % % % % % % %

E2824 E2885 E2301 E1010 E2516 E2304 E1010 E0025 E2318 E0801 E2362

BS PF HD BS CO II, IB, PR BA, DM BS BS CO II, ERS, RC PC PA, SA

%

E0115

BS

% % % % %

E2516 E2452 E2933 E2950 E1800

CO II, IB, PR CO I, IB PF PR, IB DM, MA

% %

E0151 E0151

PR PR

% % % % % % % % % % % % %

E0801 E1001 E2445 E1015 E2474 E2934 E1000 E0963 E1013 E0010 E1357 E0003 E1004

PC SH CO I, HD CO II, RC TD PF RC DM, MA RC BS PF BS BS

%

E2426

CO II, IB


Substance / Synonyms

Concentration

Nystatin 2 O Oak Moss Absolute 1 Octyl Dimethyl PABA see 2-Ethylhexyl-p-Dimethylaminobenzoate 10 Octyl Gallate 0.3 Octylisothiazolinone 0.025 Octyl Methoxycinnamate see 2-Ethylhexyl-p-Methoxycinnamate 10 Orange Oil 2 Oxybenzone 10 Oxytetracycline 3 P p-Methylaminophenol Sulphate (Metol) 1 p-Toluenediamine 1 PABA see p-Aminobenzoic Acid 10 Palladium Chloride 1 p-Aminophenol see 4-Aminophenol 1 Panthenol see Dexpanthenol 5 Paraben Mix 16 Paraphenylenediamine free base 1 Paratertiary Butylphenol 1 Paratertiarybutyl Phenol Formaldehyde Resin 1 Parsol® 1789 see 4-tert-Butyl-4’-Methoxy-Dibenzoylmethane 10 Patchouli oil 10 Parsol® MCX see 2-Ethylhexyl-p-Methoxycinnamate 10 Patchouli oil 10 PCMC see Chlorocresol 1 PCMX see Chloroxylenol 1 Peppermint Oil 2 Phenol Formaldehyde Resin, Novolac 5 Phenoxyethanol 1 2-Phenyl-5-benzimidazole-Sulphonic Acid 10 Phenylephrine Hydrochloride (in water) 10 Phenylglycidylether 0.25 Phenylmercuric Acetate 0.01 Pilocarpine Hydrochloride (in water) 1 Polidocanol 3 Polyethylene Glycol Ointment 100 Polymyxin B Sulfate 3 Potassium Dichromate 0.5 Potassium Dichromate 0.25 Potassium Dicyanoaurate (in water) 0.002 Prednisolone 1 Primin 0.01 Procaine Hydrochloride 2

47

Art. No.

Series

% %

E2491 E1307

ME II PF

% % %

E2365 E2495 E2427

PA, SA AO, BA CO I, IB, SH

% % % % % % % % % % % % % %

E2366 E1309 E2361 E2416 E0801 E0308 E2359 E0651 E2302 E2387 E2469 E0034 E0920 E0030

PA, SA PF PA, SA ME I PC HD PA, SA DM, MC HD, PC, TD COS BS BS CO I, PM BS

% %

E2364 E2937

PA, SA PF

% % % % % % % % % % % % % % % % % % % % %

E2366 E2937 E0105 E0106 E1358 E0901 E2392 E2367 E2414 E2807 E2863 E2407 E2501 E2337 E2437 E0001 E2506 E0605 E2505 E0032 E2308

PA, SA PF CO II, IB, PR CO II, IB, PR DM, PF PM CO I, PR PA, SA ME VI ERS PR ME VI ME IV CO I, VE ME VI BS MIC DM, MC ME V BS ME IV


Substance / Synonyms

Q R S

T

Concentration

Promethazine Hydrochloride Propolis Propyl Gallate Propyleneglycol Propyleneglycol (in water) Propyl Paraben see Propyl Parahydroxybenzoate Propyl Parahydroxybenzoate p-Toluenediamine Pyrogallol Quaternium-15 Quinidine Sulphate Resorcinol Rosin see Colophony Salicylaldehyde Sandalwood oil Sesquiterpene Lactone Mix Sodiumlaurylsulfate (SLS) (in water) (Control irritant) Sodium Benzoate Sodium Metabisulfite Sodium Thiosulfatoaurate Sorbic Acid Sorbitan Sesquioleate Sulfanilamide TEGDMA see Triethyleneglycol Dimethacrylate tert.-Butylhydroquinone Tetracaine Hydrochloride Tetracycline Hydrochloride Tetraethylthiuram Disulphide Tetramethylthiuram Disulphide Tetramethylthiuram Monosulphide Thimerosal see Thiomersal Thiomersal Thiram see Tetramethylthiuram Disulphide Thiuram Mix Tin(II)-chloride Tixocortol pivalate TMTD see Tetramethylthiuram Disulphide TMTM see Tetramethylthiuram Monosulphide 4-Toluenediamine (dye complex) Toluenesulphonamide Formaldehyde Resin Tree Moss Triamcinolone Acetonide Triclosan

48

Art. No.

Series

0.1 10 0.5 5 20

% % % % %

E2356 E1207 E2497 E2323 E2472

PA ME III AO, BA CO I, VE MIC

3 3 1 1 1 1 1 20 2 10 0.1

% % % % % % % % % % %

E0153 E0153 E0308 E0350 E0031 E2358 E2865 E0017 E1359 E2936 E2459

PR PR HD PC BS PA HD, ME III BS PF PF BS

0.25 5 1 0.25 2 20 5

% % % % % % %

E2893 E2385 E2412 E2507 E0113 E1703 E2160

IR BA, COS PC, PR DM, MC BA, PR PF, PL, VE ME I, PA

2 1 1 2 0.25 0.25 0.25 0.1 0.1 0.25 1 0.5 1 0.25 0.25 1 10 1 0.1 2

% % % % % % % % % % % % % % % % % % % %

E1851 E2434 E0402 E2306 E1016 E1011 E1008 E0600 E0600 E1011 E0023 E2419 E2940 E1011 E1008 E0308 E0908 E2947 E2486 E0158

DM, MA AO, CO I ME IV ME I RC RC RC PR PR RC BS MC BS RC RC HD COS PF ME V CO I, IB, PR


Substance / Synonyms

U V W Y Z

Concentration

Tricresyl Phosphate (isomer blend) 5 Triethanolamine see Trolamine 2.5 Triethyleneglycol Dimethacrylate 2 Triethylenetetramine 0.5 Trimethylhexane-1,6-diamine (isomere blend) 0.5 Triphenyl Phosphate 5 1,3,5-Tris(2-hydroxyethyl)-hexahydrotriazine 1 Trolamine 2.5 Turpentine Oil 10 Usnic Acid 0.1 Vanillin 10 White Petrolatum 100 Wool Alcohols 30 Ylang-ylang (I+II)-Oil 10 ZDC see Bis(diethyldithiocarbamate)Zinc 1 Zinc dibenzyldithiocarbamate 1

49

Art. No.

Series

% % % %

E2511 E1701 E1851 E0905

CO I, PM CO I, PC, VE DM, MA ERS

% % % % % % % % % % % %

E2946 E0959 E0119 E1701 E2322 E2052 E1310 E8999 E0020 E2891 E1009 E2864

ERS PC, PM CO I, IB CO I, PC, VE PM PL BA, COS, PF MIC BS PF CO I, RC RC


TROLAB® substances versus INCI* names (*International Nomenclature of Cosmetic Ingredients) TROLAB substance / synonym A Abietic Acid Abitol® Adeps lanae alpha-Amyl-Cinnamaldehyde alpha-Amylcinnamyl Alcohol Amerchol® L 101 4-Aminobenzoic Acid 3-Aminophenol 4-Aminophenol Ammonium Persulphate Anisyl Alcohol B Balsam of Peru Balsam of Tolu Benzaldehyde Benzalkonium Chloride 1,2-Benzisothiazolin-3-one, Na-Salt Benzophenone 4 Benzotriazole Benzyl Alcohol Benzyl Benzoate Benzylcinnamate Benzylhemiformal Benzyl Salicylate Bisphenol A Bronopol tert.-Butylhydroquinone Butyl Hydroxyanisole Butyl Hydroxytoluene 4-tert-Butyl-4’-MethoxyDibenzoylmethane Butyl Parahydroxybenzoate Di-n-Butylphthalate C Cedarwood Oil Cetalkonium Chloride Cetylpyridinium Chloride Cetyl/Stearyl Alcohol Chloracetamide Chlorhexidine Digluconate Chlorocresol 5-Chloro-2-methyl-4-isothiazolin-3-one + 2-Methyl-4-isothiazolin-3-one (3:1 in water) Chloroxylenol Cinnamaldehyde

INCI name

Article-No.

Abietic Acid Hydroabietyl Alcohol Lanolin Amyl Cinnamal Amylcinnamyl alcohol Lanolin Alcohol (and) Paraffinum Liquidum PABA m-Aminophenol p-Aminophenol Ammonium Persulfate Anise alcohol Myroxylon Pereirae Myroxylon Toluiferum Benzaldehyde Benzalkonium Chloride Benzisothiazolinone Benzophenone-4 Benzotriazole Benzyl Alcohol Benzyl benzoate Benzyl Cinnamate Benzylhemiformal Benzyl Salicylate 4,4’-Isopropylidenediphenol 2-Bromo-2-nitropropane-1,3-diol t-Butyl Hydroquinone BHA BHT

E2382 E0915 E2335 E1303 E2888 E1750 E2359 E2301 E2302 E0306 E2887 E0008 E1652 E1350 E2339 E2471 E2500 E0159 E2388 E2889 E1351 E2450 E1102 E0965 E0107 E2434 E0111 E0110

Butyl Methoxydibenzoylmethane Butylparaben Dibutyl Phthalate Juniperus Virginiana Oil Cetalkonium Chloride Cetylpyridinium Chloride Cetearyl Alcohol Chloroacetamide Chlorhexidine Digluconate p-Chloro-m-Cresol Methylchloroisothiazolinone (and) Methylisothiazolinone

E2364 E0154 E0903 E1352 E2433 E2315 E1704 E0117 E0114 E0105

Chloroxylenol Cinnamal

50

E0115 E0106 E1301


TROLAB substance / synonym

D

E

F G

H

Cinnamyl Alcohol Citral Citronellol Clove Oil Cobalt Chloride, 6H2O Cocamidopropylbetaine Coconut Diethanolamide Colophony Copper Sulphate, 5H2O Coumarin Dexpanthenol Diazolidinyl Urea Dibromodicyanobutane 0.2 % Dibromodicyanobutane 0.3 % Dibromodicyanobutane/ Phenoxyethanol (1:4) Diethanolamine Di-n-Butylphthalate Dichlorophene Di-2-Ethylhexyl-Phthalate Dimethylphthalate Dipentene (dl-Limonene) Disperse Blue 3 Disperse Orange 3 Disperse Red 11 Disperse Red 17 DMDM Hydantoin Dodecyl Gallate Edetic Acid Disodium Salt 2-Ethylhexyl-4-Dimethylaminobenzoate 2-Ethylhexyl-4-Methoxycinnamate Ethyl Parahydroxybenzoate Eucalyptus Oil Eugenol Farnesol Formaldehyde Gamma Methyl Ionone Geraniol Glutar(di)aldehyde Glyceryl Monothioglycolate Glyoxal Trimer (Dihydrate) Hexamethylenetetramine alpha-Hexyl cinnamaldehyde Hydroquinone

INCI name

Article-No.

Cinnamyl Alcohol Citral Citronellol Eugenia Caryophyllus Cobalt Chloride Cocamidopropyl Betaine Cocamide DEA Colophonium Copper Sulfate Coumarin Panthenol Diazolidinyl Urea Methyldibromo Glutaronitrile Methyldibromo Glutaronitrile Methyldibromo Glutaronitrile (and) Phenoxyethanol Diethanolamine Dibutyl Phthalate Dichlorophene Diethylhexyl Phthalate Dimethyl Phthalate Limonene Disperse Blue 3 Disperse Orange 3 Disperse Red 11 Disperse Red 17 DMDM Hydantoin Dodecyl Gallate Disodium EDTA

E2515 E2401 E0903 E2316 E0960 E0954 E2000 E0506 E0502 E2478 E0505 E2476 E2496 E2384

Ethylhexyl Dimethyl PABA

E2365

Ethylhexyl Methoxycinnamate Ethylparaben Eucalyptus Globulus Eugenol Farnesol Formaldehyde Alpha-isomethyl ionone Geraniol Glutaral Glyceryl Thioglycolate Glyoxal Methenamine Hexyl cinnamal Hydroquinone

E2366 E0152 E1353 E1302 E2848 E0004 E2886 E1305 E2498 E0311 E2517 E2318 E2836 E0800

51

E1300 E2839 E2842 E1308 E0002 E2303 E2424 E0017 E0604 E2845 E2387 E2386 E2939 E2516


TROLAB substance / synonym

I

J L

M

N O

P

Q

Hydroxycitronellal Hydroxymethylpentylcyclohexenecarboxaldehyde Imidazolidinyl Urea Iodopropynyl Butylcarbamate Isoamyl-4-methoxycinnamate Isoeugenol Isopropyl Myristate Jasmine absolute Laurel Leaf Oil Lemon Grass Oil Lemon Oil Lilial Linalool (stabilized) Menthol 4-Methylaminophenol Sulphate (Metol) 3-(4-Methylbenzylidene)Camphor Methylisothiazolinone Methyl Heptine Carbonate Methyl Parahydroxybenzoate Monoethanolamine Neroli Oil Oak Moss Absolute Octyl Gallate Orange Oil Oxybenzone p-Methylaminophenol Sulphate (Metol) p-Toluenediamine Paraben Mix Paraphenylenediamine free base Patchouli oil Peppermint Oil Phenoxyethanol 2-Phenyl-5-benzimidazoleSulphonic Acid Phenylmercuric Acetate Polyethylene Glycol Ointment Propolis Propyl Gallate Propyleneglycol Propyleneglycol Propyl Parahydroxybenzoate Quaternium-15

INCI name

Article-No.

Hydroxycitronellal Hydroxyisohexyl 3-cyclohexene carboxaldehyde Imidazolidinyl Urea Iodopropynyl Butylcarbamate Isoamyl-p-Methoxycinnamate Isoeugenol Isopropyl Myristate Jasminum Officinala Laurus Nobilis Cymbopogon Schoenanthus Citrus Limonum Butylphenyl Methylpropional Linalool Menthol

E2883 E2368 E1306 E2336 E2935 E1354 E1355 E1356 E2892 E2930 E2304

p-Methylaminophenol Sulfate

E0801

4-Methylbenzylidene Camphor Methylisothiazolinone Methyl 2-octynoate Methylparaben Ethanolamine Citrus Amara Evernia Prunastri Extract Octyl Gallate Citrus Dulcis Benzophenone-3

E2362 E2950 E2933 E0151 E2445 E1357 E1307 E2495 E1309 E2361

p-Methylaminophenol Sulfate Toluene-2,5-Diamine please see single ingredients of the mix p-Phenylenediamine Pogestemon Cablin Mentha Piperita Phenoxyethanol

E0801 E0308 E2469 E0034 E2937 E1358 E2392

Phenylbenzimidazole Sulfonic Acid Phenyl Mercuric Acetate PEG 6 (and) PEG 32 Propolis Cera Propyl Gallate Propylene Glycol Propylene Glycol Propylparaben Quaternium-15

E2367 E2863 E2337 E1207 E2497 E2323 E2472 E0153 E0031

52

E1304 E2824 E0109


TROLAB substance / synonym R Resorcinol S Sandalwood oil Sodium Benzoate Sodium Metabisulfite Sorbic Acid Sorbitan Sesquioleate T tert.-Butylhydroquinone Thiomersal Tin (II)-chloride 4-Toluenediamine (dye complex) Toluenesulphonamide Formaldehyde Resin Tree Moss Triclosan Tricresyl Phosphate (isomer blend) Trolamine Turpentine Oil U Usnic Acid V Vanillin Y Ylang-ylang (I+II)-oil W White Petrolatum Wool Alcohols

INCI name

Article-No.

Resorcinol Santalum Album Sodium Benzoate Sodium Metabisulfite Sorbic Acid Sorbitan Sesquioleate t-Butyl Hydroquinone Thimerosal Stannous Chloride Toluene-2,5-Diamine

E2865 E2936 E2385 E2412 E0113 E1703 E2434 E0600 E2419 E0308

Tosylamide/Formaldehyde Resin Evernia Furfuracea Extract Triclosan Tricresyl Phosphate Triethanolamine Turpentine Usnic Acid Vanillin Cananga Odorata Petrolatum Lanolin Alcohol

E0908 E2947 E0158 E2511 E1701 E2322 E2052 E1310 E2891 E8999 E0020

53


Ordering procedure For all questions concerning ordering, conditions of sale, prices, delivery, terms of payment, etc. please contact your local distributor or otherwise Almirall Hermal GmbH D-21462 Reinbek 路 Germany Phone: + 49-40-727 04-0 Telefax: + 49-40-722 92 96 e-mail: info@almirall.de

List of TROLAB distributors Australia and New Zealand W.E. & M. Schroeder P. O. Box 11 AUS-Thornleigh, 2120 N. S. W. Appartment 1104/185 Macquarie Street AUS-Sydney, 2000 N. S. W. Tel.: 02-9233-3348 Telefax: 02-9233-3368 Mobile: 0418 976 359 e-mail: kathy.engelbert@bigpond.com Canada Omniderm Pharma Canada Inc. 997 Seguin Vaudreuil-Dorion, Quebec J7V OK2 Tel.: 450-458-0158 Telefax: 450-458-7499 e-mail: omniderm@videotron.ca Chile Promedar Ltda. Antonio Bellet 310 Providencia RCH-Santiago Tel.: 02-23 56 851 Telefax: 02-23 51 032 e-mail: admin@promedar.com web site: www.promedar.com 54


Czech Republic Correspondence address: PHARMIX s.r.o. MUDr. Tomás˘ Miksa Levského 3188/4 143 00 Praha 4 Tel.: 0241 404 302 Telefax: 0241 404 301 e-mail: info@pharmix.sk Finland Tamro Oyj / Pharmakon Rajatorpantie 41B FIN-01640 Vantaa Tel.: 020 445 11 Telefax: 020 445 4665 France STALLERGENES 6 rue Alexis de Tocqueville 92160 Antony - France Ligne Information Médecins: 01 55 59 20 15 Fax: 01 55 59 20 01 www.stallergenes.fr Great Britain and the Republic of Ireland Bio-Diagnostics Ltd. Upton Industrial Estate Rectory Road Upton upon Severn GB-Worcestershire WR8 OLX Tel.: 01684-59 22 62 Telefax: 01684-59 25 01 e-mail: enquiries@bio-diagnostics.co.uk web site: www.bio-diagnostics.co.uk

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Hongkong Hua Tai Pharmaceuticals Co., Ltd. Unit 301DD, Block B, 3rd Floor, Sea View Estate, 2-8 Watson Road, Causeway Bay, Hong Kong Tel.: 24 73 33 67 25 70 18 99 Telefax: 24 71 88 45 e-mail: info@hua-tai.com.hk Italy Allergopharma S.p.a. Via Stephenson 94 I-20157 Milano Tel.: 02-33 20 35-1 Telefax: 02-33 20 35-524 e-mail: info@allergopharma.it The Netherlands, Belgium, Luxembourg van der Bend B. V. P. O. Box 73 NL-3230 AB Brielle Tel.: 0181 - 41 - 80 55 Telefax: 0181 - 41 - 74 50 e-mail: info@vanderbend.nl www.vanderbend.nl Portugal DERMIS Produtos de Saúde S.A. Rua José Estêvão, nr° 17 1169-300 Lisboa Tel.: 021 3144 402 Telefax: 021 3144 404 e-mail: info@dermiskincare.com

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Slovak Republic Orders: PHARMIX s.r.o. Druzห˜stevnรก 1 834 01 Bratislava Tel.: 0241 404 302 Telefax: 0241 404 301 e-mail: info@pharmix.sk Distributor: PHOENIX Zdravotnicke zรกsobovanie a.s. Vlรกrska 48 831 01 Bratislava Tel.: 02 49999245 Telefax: 02 49999268 South Africa Mednom P.O.Box 485 Bergvliet 7864 Cape Town Tel.: 021 - 671 - 19 96 Telefax: 021 - 671 - 19 96 e-mail: mednom@absamail.co.za Spain Farmacia Diaz Moreno c/. Serafin Olave, 15 Pamplona 31008 Navarra Tel.: 0948 257 942 Fax: 0948 174 411

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Internet service Under www.hermal.com you will find information on each TROLAB@ allergen. The data are taken from literature.

06/09 – E 9105

Any comments and additional information from you are welcome.

Almirall Hermal GmbH D-21462 Reinbek


Trolab