Cannabidiverin (CBDV): What Is It? | Bona Voluntate
THC and CBD tend to dominate discussions of cannabis chemicals After all, they make up the bulk of the plant itself However, cannabis contains hundreds of chemicals, some of which, despite their low concentrations, have a disproportionately large effect. One such compound is cannabidivarin (CBDV Wholesale).
THC and CBD have dominated recent discussions about marijuana There are hundreds of compounds in this ancient plant, and many of them can work together in surprising ways to provide a seemingly infinite supply of advantages. Cannabidivarin (CBDV) is a cannabinoid that has been widely overlooked despite its enormous promise
CBDV: What Is It?
The cannabis plant produces CBDV, among more than 100 other cannabinoids. CBDV, like other "secondary" cannabinoids, is commonly present in low-THC cannabis cultivars like hemp, and in lower amounts than THC and CBD
CBDV Wholesale is a non-psychoactive cannabinoid, therefore it won't leave you feeling high or stoned like other cannabinoids like tetrahydrocannabinol (THC) We will compare and contrast the chemical structures and modes of action of CBD and CBDV, two closely related molecules
Much remains unknown about CBDV and its modes of action, as is the case with many cannabinoids. Preliminary trials of this cannabinoid, however, have provided some insight into its potential effects on the human body
CBDV, like its close relative CBD, does not have a strong affinity for the cannabinoid receptors CB1 or CB2. This is a key reason why it doesn't have the psychoactive effects of regular cannabis.
Cannabidivarin, like cannabidiol (CBD), has been shown to interact with the human endocannabinoid system, but in a much more roundabout way TRPV1 receptors (also known as capsaicin receptors) play a vital part in our ability to sense pain and warmth, and CBDV Wholesale has been shown in clinical trials to both activate and desensitize these receptors It has been suggested in other research that CBDV may influence TRPV2 and TRPA1 receptors
They are all transient receptor potential channels, a class of receptors. These channels are a part of the cell membrane and open to let ions (like sodium) into a cell when they are active Studies have shown that cannabidivarin (Buy CBDV Isolate) may inhibit diacylglycerol lipase, an enzyme critical in the biosynthesis of the endogenous cannabinoid 2-AG. However, just how CBDV accomplishes this remains unclear
CBDV: What's It Good For?
Multiple experiments and investigations have been conducted on CBDV Wholesale. Even less is known about this cannabinoid's mechanisms of action and therapeutic potential than CBD, which is unfortunate
In the following, we will review some of the CBDV literature and analyze what this informs us about the substance's role and potential However, keep in mind that these are all very early findings
Epilepsy and CBDV
A study on the effects of CBDV in rodents was published in 2013 in the British Journal of Pharmacology CBDV-rich and CBD-containing cannabis plant extracts, as well as pure versions of both cannabinoids, were administered to the animals (at varying doses). To learn more about the synergistic effects of these two cannabinoids and their separate physiological impacts, the researchers performed an isobologram analysis
Pentylenetetrazole (a circulatory and respiratory stimulant), pilocarpine, and an audiogenic seizure model (in which the animals are placed in an isolated chamber and subjected to an aural stimulus that causes a seizure) were then used to induce seizures in the rats and mice
Researchers performed isobologram analysis to test whether CBDV-rich extracts had anticonvulsant properties, and they found that the cannabinoid exerted its effects independently of CB1 receptors.
CBDV's anticonvulsant potential was also the subject of a study published in 2014 in the ACS Chemical Neuroscience journal According to the results of this investigation, the TRP channels (already identified) are responsible for delivering the effects of CBDV.
Link Between Cannabidiol and Autism
Some research has investigated the therapeutic potential of CBDV Wholesale in treating the core symptoms of autism spectrum disorder because of its ability to modulate the excitatory and inhibitory systems in the brain
This hypothesis was tested in 2019 by the journal Translational Psychiatry, which looked at the effects of CBDV on glutamate and GAMMA metabolites (markers of the brain's inhibitory or excitatory systems, respectively) in healthy people and people with autism spectrum disorder The glutamate and GABA+ levels in the brains of 34 male participants (17 with autism and 17 without) were measured using magnetic resonance spectroscopy after they had been treated with a placebo and a single dose of 600mg of CBDV in a double-blind, randomized-order, cross-over design Buy CBDV Isolate at Bona Voluntate in bulk amounts and at good prices
According to the study's authors, CBDV Wholesale did reduce glutamate levels in the brains of both groups. CBDV's potential as a treatment for the symptoms of autism spectrum disorder was investigated; however, its effects were not consistent among people, leading the authors to conclude that more research is necessary