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Girija S. Singh & Surendra N. Pandeya
Table 4. Some potential antibiotics and their targets. Class
Representative example H N
β-Lactams
Target
S
O
Cell wall
N O
COOH
Penicillin G (1) OH
NMe2 OH
H
Polyketides
Protein biosynthesis
NH2 OH
OH OH O
O
O
Tetracycline (2) O2 N
NHCOCHCl2 OH
Phenylpropanoids
Protein biosynthesis
OH
Chloramphenicol (3) NH2
Aminoglycosides
O
HO
NH2 O HO
Protein biosynthesis
H2N NH2
O
OH OH
O
HO
NH2
Tobramycin (4) O
Macrolides
Protein biosynthesis
OH
HO OH
HO
O
O
NMe2
OMeO O
O
OH
O
Erythromycin A (5) OH NH
2
Glycopeptides
H3C
O CH3 O
HO O O NH
HO
N H
O
O
O
Cl H N
O
OH Cl OH OH
O
N H
O H N O
O NH2
O
OH OH HO
Cell wall
OH O
Vancomycin
N H
H N
CH3 CH3
CH3