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Available Online at: www.ijrpp.com
Print ISSN: 2278 - 2648 Online ISSN: 2278 - 2656
International Journal of Research in Pharmacology and Pharmacotherapeutics (Research article)
PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIINFLAMMATORY ACTIVITY OF DIFFERENT EXTRACTS FROM LEAF, STEM AND BARK OF TECTONA GRANDIS *1
Shruthi D.P, 2Sunith K.E, 3Haritha Kumari E, 4Govindappa M, 5Siddalingeshwara K.G Department of Biotechnology, Shridevi Institute of Engineering & Technology, Sira Road, Tumkur-572 106, Karnataka, India. 5 Department of Biochemistry, Tumkur University, Tumkur, Karnataka, India. 1
_________________________________________________________________________ ABSTRACT Interest in natural products as a source for innovation in drug discovery and agrochemicals is still growing worldwide. Natural products, whose immense diversity has been appreciated for many years, may become in a rich source of novel chemical structures. Our country is a rich source of both biological and chemical diversity, which may be useful as a source of novel chemical structures. The timber value of Tectona grandis has been well known from decades. Teak is the major exotic species found in tropical regions. The present study was meant to characterize pharmacological potential of different extracts from leaf, bark and stem of teak. The aim of present study to investigate the preliminary phytochemical screening of Tectona grandis. This work highlights on qualitative phytochemical investigation on leaf, bark and stem. Of the Tectona grandis. A comparative phytochemical analysis was carried to prove that the amount of phyto constituents varied with the fresh and dry stages of plants contributing to the activity of the extract. Total phenolic and saponnins content of both the extracts was estimated and was found to be more in the leaf, bark and stem giving positive results and the presence of steroids and Terpenoids also showed in leaf and stem. Antioxidant activity of extracts was carried out using ferric ion reducing antioxidant power (FRAP) and 2, 2-diphenyl-1- picrylhydrazyl (DPPH) assay and anti-inflammatory activity of the Tectona grandis extract were also made.
KEY WORDS: Antioxidant, anti-inflammatory activity, Tectona grandis, phytochemical screening.
INTRODUCTION Plants are the basis for traditional medicine systems and used for thousands of year in countries such as India and China. Numbers of medicinal plants and its derived extracts are used in the treatment of various disorders by Ayurveda, Unani and Siddha systems in India. Scientifically, few of pharmacological properties have been studied to support its traditional use 1. Throughout the world, many plant species are used for the treatment of inflammation and other diseases. Despite the availability of anti-inflammatory and analgesic _________________________________ * Corresponding author: *1 Shruthi D.P Department of Biotechnology, Shridevi Institute of Engineering & Technology, Sira Road, Tumkur-572 106, Karnataka, INDIA. E-mail: shruthidavasam@gmail.com
agents searching of newer therapeutic agent in this segment from the natural plants is still progressing due to presence of diverse chemical substances that have a better alternative and safer effect on inflammation without or lesser side effects. The World Health Organisation (WHO) estimates that 80% of the world’s inhabitants continue to rely on traditional medicines systems and its products 2. Tectona grandis belonging to the family Verbinaceae is commonly called as teak. The various parts of the plants are reported to posses