Volume 10 • Issue 2 • Winter 2015
www.ECRjournal.com
A Practical Clinical Approach to the Diagnosis and Treatment of Patients with Pulmonary Hypertension Brendan P Madden
Myocardial Infarction With Non-obstructive Coronary Arteries – Diagnosis and Management Sivabaskari Pasupathy, Rosanna Tavella, Simon McRae and John F Beltrame
Home Orthostatic Training in Elderly Patients with Vasovagal Syncope – A Prospective Randomised Controlled Trial Steven Podd, Jacqueline Hunt and Neil Sulke
Takotsubo Syndrome – Stress-induced Heart Failure Syndrome Mary N Sheppard
A Valve histology showing progression of the disease
Disease Standard progression:cuff Age and(industry sex standard) Increased serum lipids Increased blood pressure Diabetes and metabolic syndrome Smoking Artery marking
Initiating factors: Biscuspid valve Generic factors Shear Stress Early lesion T cell Monocyte LDL Aorta
End-stage disease
Endothelium Ca2+ Oxidized LDL Macrophage Ang II
Fibrosa
TGF-β Osteopontin TNF-α Interleukin 1β ViewVentricularis Inflammatory Process Left ventricle
High Power of Myocytes of Calcific Aortic B Aortic-value anatomy Showing Transverse Stenosis Irregular Bands
Fibroblast
Calcification Increased alkaline phosphatase Osteoblast Increased BMP-2 Wrap CuffIncreased osteocalcin
Intelli Technology New Intelli wrap cuff
Artery marking
Normal
Aortic scleroisis
Smaller ‘acceptable range’ of placement versus brachial artery means risk of error if placed outside of range
Artery Phenotypic transformation Wnt3, Lrp5, and β catenin Bladder
Mid-to-moderate Artery aortic stenosis
Acceptable range Longer Servere aorticair bladder = larger scleroisis ‘acceptable range’ of
placement versus brachial artery Radcliffe Cardiology means risk of error if placed
Bladder
Lifelong Learning for outside of range is lower than with
standard cuff