2024 NAASC Full Program

November Annual Academic Surgery Conference (NAASC) 2024

Friday 15 and Saturday 16 November 2024

National Wine Centre

Cnr Hackney & Botanic Roads, Adelaide SA 5000

NovemberAnnualAcademicSurgery Conference

Program

Friday 15November2024

MorningSessions

9:30am ArrivalandRegistration

10:00am AcknowledgementofCountry GuyMaddern

10:02am WelcomebyChairofAcademicSurgeryCommittee JonathanKarpelowsky

SESSION1:TRANSLATIONANDINNOVATION

Chairs:MatthewRead/GavinLambert

10:04am KeynotePresentation:Howtoignitethesparkofinterestinresearchandmaintainthe passiontochangethefuture FionaWood

Sectionof AcademicSurgery

10:34am Thesurgeonsjourney:technologydevelopment,implementationandcommercialisation JosephIschia

11:04am Howdoyouelevateclinicalinnovationtothenextlevel ParisTriantis

11:19am PanelDiscussion-Q&A

11:26am MORNINGTEA

11:46am SwinburneUniversity-SponsorPresentation SRSOralPresentations

11:49am MeasuringoutcomesoffacialskincancersurgeryusingtheFace-Qskincancermodule SamuelHandshin

11:59am Isroutineaxillarystagingstillrequiredinclinicallynodenegativeearlybreastcancerin womenover74years?

KatherineGrant

12:09pm MajorAustralianurologicalcentreexperienceofactivesurveillanceinISUPprostatecancer andPI-RADS4/5lesion

DarrenLam

SESSION2:NOVELTECHNOLOGY

Chairs:ChrisVarghese/JocelynLippey

12:19pm Applyingdigitaltechnologiestosupportresearch WilhelmIntegratedSolutionsPtyLtd

12:26pm MedicalimageanalysisandAI SergeiBedrikovetski

12:41pm Safeimplementationofroboticsurgery-firstdonoharm HelenMohan

12:56pm Theethicsofearlyadoptionanddevelopmentofnoveltechnology TamNguyen

1:11pm PanelDiscussion-Q&A

1:18pm LUN

NovemberAnnualAcademicSurgery Conference

Program

Friday 15November2024

MorningSessions

Sectionof

AcademicSurgery

g r a m

SRSPosterPresentations

2:03pm UseofGenerativeArtificialIntelligenceinSurgicalEducation EricYang

2:08pm Theimpactofformalteachinginresearchmethodsafterprimarymedicalqualificationson surgicalresearch:Ananalysisofshort-termresearchoutput MeetPatel

2:13pm TheUtilityofIVCDiameterfortheAssessmentofHypovolaemicShockinAdultTrauma Patients NandiniKarthikeyan

2:18pm TrendsandPredictorsofTotalNeoadjuvantTherapyinRectalCancer:ABi-NationalRegistry StudyacrossAustraliaandNewZealand IshraqMurshed

2:23pm Tertiarycentreexperienceofhigh-volume,low-riskprostatecancer:active surveillance versusradicaltherapy DarrenLam

SRSOralPresentations

2:28pm Combinationofhormonaltherapyandmitochondrial-targetedtherapyasanovelstrategy forbreastcancertreatmentinhumanbreastcancercelllines MariaAhsan

2:38pm CadavericSectioningandScapholunateInstability JoshuaAndrews

2:48pm EvaluationofDeepLearningforHighb-ValueDiffusion-WeightedMRIinBoneandSoftTissue TumourAssessment StevenZhang

2:58pm ProteomicsInternational-SponsorPresentation

3:01pm AFTERNOONTEA

SESSION3:BEYONDRESEARCH

Chairs:JonathanKarpelowsky/SiobhanMcKay

3:21pm IntroductionofSocietyofUniversitySurgeonsSpeaker MatthewRead

3:23pm Work-lifeintegrationforacademicsurgeons SocietyofUniversitySurgeonsPresentation RebekahWhite,SUSPresident2022-2025

3:43pm Overcomingimpostersyndrome(highperformancecoaching) MarkBray

3:58pm Fromarmourandposturingtovulnerableandhuman:becomingarealsurgeon BenLoveday

4:13pm PanelDiscussion-Q&A

NovemberAnnualAcademicSurgery Conference

Program

Friday 15November2024

AfternoonSessions

Sectionof

AcademicSurgery

SESSION4:ABSTRACTPRESENTATIONS

Chairs:JonathanKarpelowsky/SiobhanMcKay

SRSOralPresentations

4:20pm KeyStakeholderperspectivesonimplementationofRiskBasedbreastcancerscreening JocelynLippey

4:30pm ChronicRenalFailureasaPredictorofPostoperativeMorbidityandSurvivalin Colorectal CancerSurgery:ARetrospectiveMulticenterAnalysis YajatDua

4:40pm ComparisonofIntraoperativeComplicationsinObesevsNon-obeseinLiverCancer Surgery JackMenzie

4:50pm PatientandclinicianprioritiesinPeripheralArteryDiseasemanagementusingMultiple CriteriaDecisionAnalysis NimaIrnapour

SRSPosterPresentations

500pm KinematicandKineticdifferencesinpaediatricandadolescentrecurrent patellofemoral dislocatorsusingasubject-specificgaitanalysismodel AngelAulakh

5:05pm LivingandDyingWell:JuniorDoctors'PerspectiveonConversationswithPatients RegardingResuscitationStatus,DeathandDying TachelleTing

5:10pm Neoadjuvantchemotherapyinlocallyadvancedcoloncancer:asystematicreviewand meta-analysis RathinGosavi

5:15pm OutcomesofaSingleCentreRegionalRenalPhysician-ledDialysisAccessClinic:A ComparativeStudy NimaIranpour

520pm In-vivotestingofBacteriophagetherapyforChronicRhinosinusitiswithAntibiotic and phageresistance KaviyaKalyanasunduram

5:25pm ENDOFPROGRAM-DAY1

6:30pm ConferenceDinner

TheVinesRoom,NationalWineCentre

NovemberSurgicalResearchSociety ofAustralasiaConference

Program

Saturday 16November2024

MorningSessions

8:00am

SurgicalResearch Societyof Australasia

EarlyCollaborativeStudyIdeasWorkshop Panel:DavidBeard,GuyMaddern,HelenMohan,DavidWatson

9:00am ArrivalandRegistration

9:15am WelcomebyChairofAcademicSurgeryCommittee JonathanKarpelowsky

SESSION5:WHATREALLYMATTERS

Chairs:MattRead/SIobhanMcKay

9:19am Refinancer-SponsorPresentation

9:21am PlenarySpeaker:Whystudiesfail DavidBeard

9:51am Whatistherightquestion:thepatientperspective ChrisBaggoley

10:06am Increasingsurgicaltrials:AGITGandRACScollaborativeopportunities AmiteshRoy

10:21am HowwillRACSsafeguardsupportforsurgicalresearchnowandinthefuture? StephanieClota,CEORACS

10:36am PanelDiscussion-Q&A

10:46am MORNINGTEA

SRSOralPresentations

11:06am Theimpactofchymereinfusiononpost-operativerecoveryfollowingloopileostomy reversal:arandomisedcontrolledtrial ChenLiu

11:16am TheeconomicandenvironmentalfootprintofPrecisionPointprostatebiopsies KylieLim

SESSION6: DATAANDREACH

Chairs:RebekahWhite/GlenGuerra

11:26am BD-SponsorPresentation

11:28am Measuringtheunmeasured-Identifyingmetricsbeyondtheusual MartySmith

11:43am Harnessingthepowerofbigdatathroughcollaboration AngusDixon

11:58pm Howtomap,measureandmeetyourmilestones-makingyourresearchmore impactful EddeSalis

12:13pm PanelDiscussion-Q&A 12:23pm LUNCH

NovemberSurgicalResearchSociety ofAustralasiaConference

Program

Saturday 16November2024

MorningSessions

SurgicalResearch Societyof Australasia

SRSPosterPresentations

1:08pm Post-OperativeFunctionalAssessmentinAnaemicPatients-aFeasibilityStudy

JaahnaviSaiCheyyur

1:13pm ASurveyofSurgeon'sPerceptionsofDefiningandRecordingComplicationsAssociated withElective,EmergencyandNonoperativeSurgicalAdmissions

MartySmith

1:18pm Comparisonofpre,midandpost-pandemicemergencycolorectalcancerpresentations attheSunshineCoastUniversityHospital

MarcioCoelho

1:23pm Auditofaudiology-ledfollow-upforgrommetinsertion

SophieDunmall

1:28pm EconomicEvaluationof‘WatchandWait’followingNeoadjuvantTherapyinLocally AdvancedRectalCancer:ASystematicReview

IshraqMurshed

SRSOralPresentations

1.33pm Definingthehospitalvolumerequiredtominimisemortalityfollowingesophagectomyfor cancerinlowpopulationdensitycountries

JosipaPetric

1:43pm Defining‘failuretorescue’afterpostoperativecomplications:asystematic reviewand population-basedstudy

CameronWells

153pm OutcomesfollowingLaparoscopicRepairofVeryLargeHiatusHerniasintheMorbidly Obese MathewAmprayil

203pm Non-technicalerrorsassociatedwithadverseeventsintheAustraliansurgical population:aneight-yearretrospectiveanalysis

2:13pm

JesseEy

Cephid-SponsorPresentation

SESSION7:JEPSONLECTURE

Chair:GuyMaddern

2:16pm IntroductionofJepsonLecturer GuyMaddern

2:19pm JepsonLecture-Drivingchangeinsurgery-Evidence,opinionorbelief? DavidWatson

Program

ofAustralasiaConference

Saturday 16November2024

AfternoonSessions

SurgicalResearch Societyof Australasia

SESSION8: INVITEDUSAPRESENTERSFROMTHESUSANDAAS Chairs:DavidBeard/HelenMohan

2:39pm IntroductionofAssociationforAcademicSurgerySpeaker JonathanKarpelowsky

2:41pm

AorticTissueCytokinesareincreasedinindividualswithaorticaneurysmaland occlusivedisease

MohamedZayed-AASOverallBestAbstractbyanAASMemberAwardRecipient2023

3:01pm Immuneeffectsofirreversibleelectroporation RebekahWhite

3:16pm PanelDiscussion-Q&A

3:21PM AFTERNOONTEA

3:41pm NexusMD.AIPtyLtd-SponsorPresentation

SRSOralPresentations

3:44pm TheSterileCockpit-Whatcanwelearnfromaviation?

EllieTreloar

3:54pm

Theeffectsofpreoperativeoralantibioticsonanastomotichealingandmucosal microbiomeinamousemodelofcolonicresection

SamwelMakanyengo

4:04pm PredictorG-AmulticentretranslationalpersonalisedmedicineapproachinColorectal PeritonealMetastases

AnshiniJain

4:14pm PlasmalignocainelevelsafterIVlignocaineinfusionandregionalabdominalwallblocks inlaparoscopiccolorectalneoplasiaresectionsurgery NicoleTham

SESSION9: FINALSESSION Chairs:MattRead/DavidWatson

4:24pm Researchcollaborativeupdate-whereareweandwhereshouldwebegoing? ChrisVarghese

4:34pm EarlyCollaborativeStudyIdeasFinalistsPresentation1 SelectedfromEarlyCollaborativeIdeasWorkshopPresentations

4:39pm EarlyCollaborativeStudyIdeasFinalistsPresentation2 SelectedfromEarlyCollaborativeIdeasWorkshopPresentations

4:44pm SRSAwardPresentations JonathanKarpelowsky

5:04pm ClosingRemarks MatthewRead

5:14pm ENDOFPROGRAM

WelcometotheNovemberAnnualAcademicConference2024!

AnticipationmountsaswegearuptohostthiseventattheNationalWineCentrein Adelaide,SouthAustralia Ourdiligentcommitteehasmeticulouslycuratedan outstandingprogram,showcasingadistinguishedrosterofspeakerspoisedtodelve intopivotalsubjectswithinacademicsurgery Theirpresentationsarepoisedto captivate,inspire,andkindleyourenthusiasmforthefield.

WeextendawarmwelcometoourcolleaguesfromtheUnitedStates,includingDr RebekahWhite,PresidentoftheSocietyofUniversitySurgeonsandDr Mohamed ZayedfromWashingtonUniversityinSt.Louis,whowillbejoiningus.

Thisyear,weareprivilegedtowelcomeProfessorDavidWatson,HeadoftheFlinders UniversityDepartmentofSurgeryandisanOesophagealandGastricSurgeonat FlindersMedicalCentre,ashedeliverstheesteemedJepsonLecture.

Weextendourthankstothededicatedorganisingcommittee(RACS)fortheirhard workincoordinatingthisconference Wealsorecognisetheexceptionalcolleagues whocontributedsignificantlytothesuccessofthissignificantannualevent facilitatedbytheSectionofAcademicSurgery

TheSectionofAcademicSurgeryhasdecidedtocombinetheDevelopingaCareer andSkillsinAcademicSurgeryprogramwiththeNovemberAnnualAcademic SurgeryConference(NAASC)in2025 Thisstrategyenablesustofocusourresources onasingleevent,ensuringitupholdsthehighestqualitystandards Weeagerly anticipatethisnewformatandlookforwardtoseeingyouin2025

Ouragendathisyearhasbeenthoughtfullydesignedtooffervaluetoallparticipants, nomatterwheretheyareintheircareers

Wewishyouawonderfuldayandtrustthattheconferencewillbebothenlightening andmotivatingforyou

ProfessorJonathanKarpelowsky Chair,AcademicSurgeryCommittee Chair,SurgicalResearchSocietyofAustralasia

Committee

WelcometotheNovemberAnnualAcademicSurgery ConferencefromtheOrganisingCommittee!

Weareexcitedtopresentacarefullycraftedprogram thatexploresthesignificanttopicsofLeadershipand Engagement,CreatingImpactthroughResearch,andthe ImpactofBigDataonSurgery

Ourlineupincludesawell-balancedmixofpresentations thataimtoengageattendeesatallstagesoftheir careers

Thisyear'sprogramhasundergonechangesin anticipationforthenewcombinedDevelopingaCareer andskillsinAcademicSurgeryCourseandNAASCin 2025.TheConferencehasbeenrescheduledtoaFriday andSaturdayformatandthepreviouslystand-alone SurgicalResearchSocietydayandAcademicSurgery dayhavebeenmergedintoacohesiveprogram Quick oralpresentationshavenowbeensubstitutedwith posterpresentations Wearethrilledtoannouncethat wereceivedmorethan80abstractsfortheeventwhich isanoutstandingresult

Forthefirsttime,wewillhostan‘EarlyCollaborative StudyIdeasWorkshop’togathernewcollaborativestudy ideasfromAustraliaandNewZealand Selectedideas willbepresentedtoapanelofexpertsinsurgicaltrials andresearchmethodologiesforfurtherdevelopment Thetoptwoideaswillbeshowcasedonthefinalday, withaprizeawardedforthebestpresentation

WearehonouredtohaveDrRebekahWhiteasour speakerfromtheUnitedStateswhowillpresent“Immune effectsofirreversibleelectroporation” DrWhiteisthe ProfessorofSurgeryattheUniversityofCalifornia,San DiegoandPresidentoftheSocietyofUniversitySurgeons, USA

Awarmwelcomeisalsoextendedtoouresteemedguest speakerfortheAssociationforAcademicSurgery(AAS), Dr MohamedZayed Dr Zayedwillbepresentingonthe topic,“AorticTissueCytokinesareIncreasedin IndividualswithAorticAneurysmalandOcclusive Disease,”whichhasbeenrecognisedastheAASOverall BestAbstractbyanAASMemberAwardRecipientfor 2023

Wetrustthatyouwillenjoytheconferenceandfindit thought-provokingandinsightful

DrMatthewRead OnbehalfoftheNovemberAnnualAcademicSurgery ConferenceOrganisingCommittee

Amessagefromoursponsor

AboutWilhelm

We’reanAustralianownedhealthcaretechnologycompanyonamissionto improvehealthinAustraliaandNewZealand

Weexisttoraisethebaronhealthstandardsinaworldneedingandexpecting greaterprotection,wherethishasbecomemorechallengingthaneverbefore. Technologyenablesustoleadthewayinmodulardesignandconstruction, infectioncontrol,safetyanddigitalhealth,throughlocallyengineeredsolutions, harnessingthelatestininnovationhereandfromtrustedbrandsoverseas.

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Ourteamhassomeofthemostexperiencedandconnectedexperts,dedicated t

InvitedSpeakers

SocietyofUniversity Surgeons,USA

DrRebekahWhite

RebekahWhite,MD,isasurgicaloncologistandProfessorofSurgeryatUniversityof CaliforniaSanDiego(UCSD)

ShecompletedmedicalschoolandgeneralsurgeryresidencyatDukeUniversityin NorthCarolina Duringresidency,sheworkedforthreeyearsinanucleicacid therapeuticslaboratory,whichwouldbecomethefocusofherresearchcareer

Aftergeneralsurgeryresidency,shecompletedsurgicaloncologyfellowshipat MemorialSloan-KetteringCancerCenterthenreturnedtoDukeasfacultyin2007She becameinterestedinirreversibleelectroporation(IRE),bothasaclinicaltherapyfor patientswithlocallyadvancedpancreaticcancerbutalsoforitspotentialtohelp overcomesomeofthebarrierstodeliveryofnucleicacidtherapeuticstotumors.

In2016,shewasrecruitedUCSD,whereherNIH-fundedlaboratoryiscurrentlyfocusedonnoveltherapeuticapproachesto pancreaticcancer,includingaphaseIclinicaltrialofIREcombinedwithimmunotherapy

HerUCSDtimeisdividedroughly50/50betweenclinicalandresearchactivities OutsideofUCSD,sheisinvolvedinseveral surgicalorganizations,includingtheSocietyofUniversitySurgeons(asaPast-President).

Associationfor AcademicSurgery

DrMohamedZayed

WashingtonUniversityinStLouis,USA AssociationforAcademicSurgery(AAS)OverallBestAbstractbyan AASMemberAwardee

Dr.MohamedZayedisavascularsurgeon,scientist,academicentrepreneur,and educator HeiscurrentlytheChiefoftheDivisionofSurgicalSciencesandProfessor withTenureinSurgery,Radiology,andMolecularCellBiologyatWashington UniversitySchoolofMedicine.HeisalsoanaffiliatedProfessorofBiomedical EngineeringattheWashingtonUniversityinSt.LouisMcKelveySchoolof Engineering Dr ZayedearnedanMDandPhDfromUNC-ChapelHill,andanMBA fromWashingtonUniversity Hecompletedhissurgicaltraininginvascularsurgery atStanfordUniversity

HeisaBoardofSurgerycertifiedvascularsurgeonandcurrentlypracticesgeneralvascularsurgerywithafocuson peripheralarterialandvenousocclusivedisease HeisrecognizedasadistinguishedfellowoftheSocietyforVascular Surgery(DFSVS),afellowoftheAmericanHeartAssociation(FAHA),andafellowoftheAmericanCollegeofSurgeons (FACS).HewaspreviouslyaVascularCuresFoundationWylieScholar,andanAmericanSurgicalAssociation(ASA) FoundationFellow

AtWashingtonUniversity,Dr ZayediscurrentlyDirectorofVascularSurgeryResearch,andDirectorofthemultidisciplinaryCardioVascularResearchInnovationinSurgeryandEngineering(CVISE)Centerthataimstosynergize surgeonsandengineersindiscovery,testing,andcommercializationofnovelbiomedicalconcepts

HeisPIandCo-PIofmultipleactiveNIHandfoundationresearchgrantsevaluatingcriticaltopicsinatheroprogression, aorticaneurysmaldiseaseformation,molecularimagingofvasculardisease,andxenotransplantationusingvascular grafts

Overthepast5years,Dr Zayedhasfiled>40patentapplications,wasawarded4issuedUS patents,andhasco-founded threestartupbiomedicalcompanies.

InvitedSpeakers

JepsonLecturer

ProfessorDavidWatson

MBBS,MD,FRACS,FAHMS

ProfessorWatsonisProfessorandHeadofSurgeryatFlindersUniversity,andan OesophagogastricSurgeonatFlindersMedicalCentreinAdelaide

Hisinterestsincludegastro-oesophagealreflux,andoesophagogastriccancer He leadsresearchaddressingbenignandmalignantesophagealdisease,integrating laboratory,clinicalandpopulationresearchstreams

Hehaspublishedmorethan500papersandbookchapters ProfessorWatsonledthe establishmentoftheAustraliaandAotearoaNewZealandGastricandOesophageal SurgeryAssociation(AANZGOSA)asitsfoundationPresidentfrom2006-10

JepsonLecturer

HehasservedonCouncilfortheAustralianAcademyofHealthandMedicalSciences(AAHMS) HeisaPast-Presidentfor theInternationalSocietyforDiseasesoftheEsophagus(ISDE),andwasClinicalDirectorfortheRACSClinicalTrialsNetwork AustraliaandNewZealand(CTANZ)from2018-23

ProfessorWatsonhasbeenarecipientoftheJohnMitchellCrouchFellowshipfromtheRACS,aJamesIVTravelling Fellowship,HonoraryFellowshipoftheRoyalCollegeofSurgeonsofEdinburgh,electiontoFellowshipoftheAustralian AcademyofHealthandMedicalSciences,andappointmenttoaMatthewFlindersDistinguishedProfessorshipatFlinders University

Amessageforoursponsors

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Amessageforoursponsors

ThinkingofgainingAmericanCollegeofSurgeon’s Fellowship?ApplicationsforInternationalFellowship closeDecember1st ContacttheANZChapter secretariatatanz.acs@surgeons.orgforfurther informationonapplyingforFellowshipand becomingamemberoftheANZChapter.

TheANZChapteroftheACSisproudtosupportthe SRSNovembermeeting

Elsevierisaglobalinformationanalyticsbusinessthathelps institutionsandprofessionalsadvancehealthcare,open scienceandimproveperformanceforthebenefitofhumanity

ThroughtheRACSLibraryyouhaveaccesstoClinicalkey wwwclinicalkeycomauClinicalKeyprovidescliniciansand researcherswithaccesstotheeBooks,Journals,Clinical Overviews,AMHDrugMonographs,latestresearchincluding ClinicalTrials Userscanalsotracktime-basedCME/CPDwhen reviewingeBooks,JournalsandClinicalOverviews

Ifyouwouldlikemoreinformationpleasereachouttothe RACSlibraryorcontactcustomerengagement@elseviercom

InvitedSpeakers

ProfessorChrisBaggoley

ProfessorChrisBaggoleyAO,enrolledintheFlinderspostgraduatemedicalprogram in1974aftercompletingadegreeinveterinaryscience,decidingthathisdestinylay inhumanhealthcare

ProfessorBaggoleywasappointedChiefMedicalOfficerfrom2011to2016and quicklyhadtocometotermswiththecontradictionsbetweenapublicafflictedby epidemicsofnon-communicablediseasessuchasobesityandheartdisease,but primarilyengagedinconcernoverrelativelyrarecommunicablediseases,suchas Ebolaandnewformsofinfluenza

HeistheDeputyChairoftheAustralianPancreaticCancerFoundationsince2020 andisalsoaboardmemberofCalvaryHealthcareandFlindersCharlesDarwin UniversitiesHealth

JepsonLecturer

Chrisalsoservesonthefollowingcommittees:

WorldHealthOrganisation:IndependentOversightandAdvisoryCommitteefortheWorldHealthEmergency Programme 2021

CalvaryHealthcare:ClinicalGovernanceCommittee–Chair.2021

SAHealth:PaediatricCochlearImplantOversightCommittee–Chair 2023

AustralianMedicalCouncil:RecognitionofRuralGeneralistMedicineasasubspecialtyofgeneralpractice–Chair 2023

CancerAustralia:AustralianComprehensiveCancerNetworkCommittee,consumerrepresentative.2024

ProfessorDavidBeard

DavidBeardisProfessorandSurgical&ComplexInterventionTrialsProgramLeadat theNHMRCClinicalTrialsCentre,UniversityofSydneyinaroleevaluating(panspecialty)surgerybutwithaspecialinterestinMSKandplastics HeisalsoProfessor ofMusculoskeletalandSurgicalSciencesattheNuffieldDepartmentof Orthopaedics,RheumatologyandMusculoskeletalSciences(NDORMS),Universityof Oxford,andtheRCSEngDirectoroftheSurgicalInterventionTrialsUnit(SITUNDORMS)

Clinicallyqualifiedasaphysiotherapist,hehasMastersdegreesinBiomedical Science(KCLLondon,andOxon),aDoctorateinMedicine(Oxon),andhonorary fellowshipsfromtheRoyalCollegeofSurgeonsFRCS(Eng),andtheBritish OrthopaedicAssociation(FBOA)

Asaclinicianscientist,heisaninternationallyrecognisedexpertinsurgicaltrialsevaluationandhasledmanyunique designpractice-changingtrials(ACLSNNAP,CSAW,TOPKAT),allpublishedinveryhigh-leveljournals HeisalsoaNIHR SeniorInvestigatorandanNHMRC(L3)Investigator

MarkBray

MarkJBray

Founder/Director-MakeOne’sMark MeetMark,Investor,ExecutiveCoach,andMentorExtraordinaire

Withover35yearsofinternationalexperienceinthemultipleindustries,Markisa dynamicleaderknownforhisgroundbreakingstrategiesandvisionaryleadership He’s notjustaboutguidingbusinesses;he’spassionateaboutunlockingtheextraordinary withinindividuals,helpingthemexceedtheirownexpectationstouncoverwhattruly drivesthem.

Mark’suniquetalentliesinconnectingpeopletotheirinternalcompass,aligningtheir valueswiththeiractions,andunleashingtheirfullpotential Hisprovensuccessin revitalisingbusinessesspansacrosspeople,strategy,andworkspaces makinghima highlysought-afterspeaker

InvitedSpeakers

DrSergei

Bedrikovetski

DrSergeiBedrikovetskiisanAdjunctSeniorLecturerandResearchOfficeratthe UniversityofAdelaideandamemberoftheRoyalAdelaideHospitalColorectal ResearchGroup HeholdsaBachelorinHealthSciencesfromtheUniversityof Adelaide,wherehewasawardedfirst-classhonoursin2018.

In2023,hecompletedhisPhDincolorectalcancersurgery,receivingtheDean’s CommendationforDoctoralThesisExcellence FollowinghisPhD,hespentayear workingasaResearchOfficeratRoyalAustralasianCollegeofSurgeonsinAdelaide.

Sergei’sresearchinterestsincludesurgicaloncology,neoadjuvanttherapiesfor advancedrectalcanceranddevelopmentofstatisticalandartificialintelligence predictionmodels.

StephanieClota

StephanieClotaistheCEOofRACSandahighlyrespectedandexperienced leaderwitharemarkabletrackrecordofsuccessinthehealthcareand trainingsectors

Herexpertiseisinstrategicdecision-making,financialperformance,policy andadvocacyandcorporategovernance

Herabilitytobuildandmaintainkeypartnershipswithgovernment,private, andnot-for-profitorganisationshasbeeninstrumentalinstrengthening practitionerdevelopmentandensuringitmeetstheevolvinghealthcare needsofcommunities

EdDeSalis

Edbringsover25yrsexperienceininvestmentbanking,dataanalyticstechnology andpredictivemodelling

HehasworkedforinternationalinvestmentbanksinAsiaandNewYorkandmanaged thetreasuryriskmitigationteamsforHBOS/Lloyds,NomuraandNABinAustralia.

Morerecentlyhefoundedtwodatadrivensoftwarestartupsandaftersuccessfully exitingin2021,heworkedondata&AIprojectsforIAG.EdholdsaBCommAccounting andFinance(UNSW),DiplomainAppliedFinance(FINSIA)andAI:Implicationsfor BusinessStrategyProgram(MITSloanSchoolofManagement)

AngusDixon

Withover30yearsofexperienceinthehealthcaresector,AngusDixonhasheldkey leadershiprolesinbothinternationalandAustralianhealthcareorganizations,including Stryker,aswellasAustraliancompaniessuchasSurgicalSpecialtiesandGlobal Orthopaedics.

Hisexpertisespansorthopaedicmedicaldevicesand,morerecently,hospitalfacility upgrades,withaparticularfocusonhigh-riskclinicalareassuchasoperatingrooms, intensivecareunits,andemergencydepartments.

Since2018,AngushasworkedwithWilhelmIntegratedSolutions,whereheledinitiativestoimprovepatientoutcomes, particularlybyreducingcomplicationsrelatedtoinfections Drivenbyapassionforenhancingpatientsafetyandreducing infectionrates,AngusledaMedicalAdvisoryPanelfocusedonHealthcare-AssociatedInfections(HAIs).Thisworkculminated inthefoundingoftheDaylightFoundationin2023,anot-for-profitorganizationcommittedtodrivinginfectionratestozero andsavinglives Formoreinformation,pleasereachoutatangus@daylightfoundationorgauorvisitourwebsiteat wwwdaylightfoundationorgau

InvitedSpeakers

JosephIschia

DrJosephIschiaisaurologistatAustinhealthandanAssociateProfessorat theUniversityofMelbourne.

Hestartedapodcastin2016,TalkingUrology,whichlooksbelowthehoodof thelandmarkpapersinurology.

HeistheCEOandfounderofAkeekothathasdevelopedauretericstent insertiondevicewhichisanoperatingroominthepalmofyourhandthat hasthepotentialtotransformthemanagementofacuterenalcolic.

DrBenLoveday

JepsonLecturer

DrBenjaminLovedayisHeadoftheHepatobiliaryandUpperGIUnitatthe RoyalMelbourneHospital,cancersurgeonatthePeterMacCallumCancer Centre,DirectoroftheUpperGastrointestinalTumourStreamacrossPeter MacandtheRoyalMelbourneHospital,andHonoraryClinicalAssociate ProfessorattheUniversityofMelbourne

BenismarriedtoaPaediatricianwhorecentlysubmittedherPhD,andthey havetwohighschoolagedchildren.

Thereare8musicalinstrumentsandaballetbarreinhishouse,representing wherethefamilyinvesttheirtime

DrHelenMohan

MBBChBAOBMedSciFRCSIFRACSPhDDipClinLeadershipDRCOG

Dr HelenMohanisanIrishtrainedclinician-researcherandsurgicaleducator workinginAustralia.Sheisaconsultantsurgicaloncologist,roboticandcolorectal surgeonatPeterMacCallumCancerCentreandAustinHealth,MelbourneAustralia HelengraduatedfrommedicalschoolwithfirstclasshonoursatUniversityCollege Dublin(UCDDublin)in2007andsubsequentlycompletedpost-graduatebasicand highersurgicaltrainingattheRoyalCollegeofSurgeonsofIreland.

ShemovedtoAustraliain2021topursuefellowshiptraininginroboticandadvancedcancersurgery Shecompleted fellowshipsatPeterMacCallumCancerCentreandAustinHealth,andcurrentlypractisesasaConsultant/StaffSurgeonat bothsites.Herclinicalinterestsincluderoboticapproachestocolorectalcancer,cytoreductivesurgeryandHIPECandpelvic exenteration.

SheisaSeniorLecturerattheUniversityofMelbourne SheisthesectioneditorforSurgicalLearningontheJournalofRobotic SurgeryandonthecolorectaladvisoryboardforEJSO SheisafoundingmemberoftheIrishSurgicalResearchCollaborative (ISRC)andtheInternationalColorectalOutcomesRegistryCollaborative(ICORC).Shehasover120peer-reviewedpubmed indexedpublicationsinthepast5yearsandaHindexof30.Shetakesanactiveleadershiproleinroboticsurgicaleducation andwasanauthorontheRACSroboticworkingpartyreport SheistheDirectorofClinicalResearchattheInternational MedicalRoboticsAcademy(IMRA)andhassetupagraduateresearchprogrammeonadaptivetrainingsolutionsinminimally invasivesurgeryatIMRA.

DuringhersurgicaltrainingshewasthePresidentoftheAssociationofSurgeonsinTrainingin2017,representingallsurgical traineesintheUKandIreland ShesubsequentlyrepresentedUKandIrishsurgicalcolorectalsurgicaltraineesontheDukes ClubtoACPGBI Shedevelopedanddeliveredaneducationalprogrammefortheadvancedcancercommitteeofthe AssociationofColoproctologistsofGreatBritainandIreland(ACPGBI)in2021.ShewastheRCSIProgressinsurgeryfellowship recipient,andtheRACS/TourdeCureCancerscholarshiprecipient.

SheattainedbothFRCSIandFRACS,aswellasdiplomasinclinicalleadershipandobstetricsandgyanecology Sheundertook 3yearsofresearchatUCDDublinandwasawardedaPhDin2016

Sheisabusymotherof4children-4yearoldtwins,ababyanda7yearold.

InvitedSpeakers

AssociateProfessorTamNguyen

AssociateProfessorTamNguyenhascloseto25yearsofworkinginthe healthcare,health&medicalresearchsectorincludingtertiaryteachinghospitals andresearchinstituteacrossAustralia

TamistheDeputyDirectorofResearchatStVincent’sHospitalMelbourne,oneof thelargesttertiaryteachingandresearchhospitalsinMelbourne-responsiblefor theorganisation’sresearchstrategy,researchethicsandgovernance,clinical trials,researchinnovationanddevelopment SVHMispartofStVincent’sHealth AustraliaNetwork–a$3Bhealthcarenetworkandthesecondlargesthealthcare providerinAustralia.

JepsonLecturer

TamteachesvariousAustralianandinternationaluniversities(NTUinSingaporeandDresdenInternationalUniversity inGermany)onvarioustopicsincluding:RWEinclinicalresearch;ClinicalEvidenceinDigitalHealthandAIValuebasedHealthcare HecurrentlyholdsacademicappointmentswithMelbourneMedicalSchoolandMonashMedical School-twooftheworldtop30(andAPACtop5)medicalschools

Taminvestsandadviseshealthtechstar-upandscale-upcompanies.He’sanInvestmentCommitteemember, Horizon3Healthcare,a$100Mfundinvestinginhighqualitybiotechandmedtechcompanies Asanindependent consultant,TamworkedwithvariouslocalandinternationallargeenterprisesandSMEs onclinicaltrialstrategy,Australia’smarketanalysisandmarketexpansion,patientengagementandclinicaltrials technologydevelopment.

HeisaregularinvitedspeakeronabroadrangeoftopicsonAIinHealthcareandhealthcareinnovation Hechairs andmoderatesatnumerousnationalandinternationalconferences Tamistheco-editoroftherecentlypublished bookAIinMedicine:Applications,LimitationsandFutureDirections(SpringerNature).

AssociateProfessorAmiteshRoy

A/ProfAmiteshRoyisaseniormedicaloncologistattheFlindersMedicalCentre(FMC) andclinicianresearcherinFlindersCentreforInnovationinCancer,FlindersUniversityin SouthAustralia

Heisregardedanexpertinthemanagementingastrointestinal(GI)malignancies,with extensiveexperienceinearlyphasetolatephaseclinicaltrialdesignandsetup,and translationalresearchinGIcancers Heisoneofthefoundingmembers(co-Director)of theSouthernOncologyClinicalResearchUnit,aphaseIunitbasedinAdelaide Heisa currentmemberoftheCancerState-wideClinicalNetworksteeringCommitteeinSouth Australia

A/ProfRoyisthecurrentDeputyChairoftheAustralasianGastro-IntestinalTrialsGroup’s (AGITG)UpperGICancerWorkingPartyandamemberoftheScientificAdvisory CommitteeandResearchOperationsCommitteeinAGITG

Hehasco/authored>120publicationsincludingpublishedpapers,conferenceabstracts andbookchaptersandhasreceived$3.5millionincontinuousfundingoverthelast5 years,includingfundingfromtheMRFF,CancerAustraliaandindustryfunding

InvitedSpeakers

DrMartySmith

DrMartySmithspecialistHPBandGeneralAcademicsurgeonworkinginMelbourne

WiththebackgroundofacompletedBachelorofScience(GeneticsandMicrobiology) DrSmithwentontostudyMedicineattheFlindersUniversityofSouthAustralia(BMBS) DrSmiththentrainedingeneralsurgeryattheAlfredhospitalinMelbourne completinghisfellowshipinJanuary2004.HethenundertookanUpperGIand HepatobiliaryfellowshipattheWesternHospitalinMelbournebeforetravelling overseasforfurthertraining

IntheUKhecompletedanUpperGI(Oesophagogastric)fellowshipatAddenbrookes hospitalinCambridgethenaHepato-pancreato-biliary(HPB)Surgicalfellowshipat theRoyalLondonHospital HethenspenttimeworkingwiththeLivertransplantunitat KingsCollegehospitalinLondonbeforereturningtoAustralia

DrSmithiscurrentlytheDirectoroftheHPBSurgeryunitatTheAlfredHospitalperformingHPB,UpperGastro-intestinal,General andTraumasurgery.HehasrecentlycompletedaDoctorateinClinicalSurgerythroughTheAlfredandtheUniversityofSydney successfullysubmittingathesisexaminingqualitymarkersinAcuteGeneralSurgery.HealsoworkswiththeVictorianHPB surgeryGroupatCabriniandprovidesgeneralsurgeryconsultingandoperatingatKynetonhospital

DrSmithisalsoinvolvedinsurgicalteachingatundergraduateandpostgraduatelevelsandisaformerBoard-Memberofthe ANZHPBAssociationandisacurrentmemberoftheRACSCourtofFellowshipexaminers.

Paraskevi(Paris)Triantis

Paraskevi(Paris)TriantisistheDesignCoachforMedTechVicandhasa backgroundinArchitecture,UrbanDesign,InteriorDesignandInnovationwithin healthcare

ParishasbeenlecturingOccupationalTherapyandArchitectureMastersstudents atSwinburneUniversitysince2019,andbringsthisexperienceintoMedTechVic Paris'roleseesherdevelopingworkshopsforco-designandinnovationwith variousstakeholdersandpeoplewithlivedexperienceofdisability,aswellas leadingprojectsandconductingresearch,reportsandpublicationsforvarious projectswithinMedTechVic

ParishasalsodevelopedandruntheClinicalInnovationFellowshipat MedTechVicsinceitsinceptionin2021,providingherwithadeepunderstandingof theclinicalinnovationprocess

Paris'passionliesindevelopinghuman-centredsolutionswithinhealthcare, bringingenthusiasmandfuntotheprocess.

ChrisVarghese

ChrisVargheseisajuniordoctorandPhDcandidatepursuingacareerin academicgeneralsurgery Hisresearchinterestsincludesurgicalrecovery, GIphysiology,andusingdigitalhealthtoimprovepatientcare.

InvitedSpeakers

ChadWilhelm

Since2016,ChadandtheWilhelmIntegratedSolutionsteamhavebeenrewritingthe rulesofhealthcaretechnologyinAustralia Backedbymanyyearsofindustryknowhow,they’reonamissiontodisruptthemarketwithfreshapproachesthatput cuttingedgesolutionsattheforefront.

Knownforitsoutstandingreputationforinnovationandservicedelivery,Wilhelmis challengingthestatusquo,blendinghomegrowninnovationwiththebestfrom trustedglobalpartners.Ourcommitment?Toempowerclinicians,improvepatient outcomesanddrivetruechangeinhealthcarebydrivingefficienciesanddelivering moresustainableOR,ICUandEDfacilities;greatlyimprovingradiationsafetyfor interventionalistsand theirteams;deliveringdatadrivendigitalsolutionsenhancingpatientoutcomes;and prioritisinginfectionpreventionandcontrol

JepsonLecturer

Chad’svisionisclear:todeliversolutionsthatdon’tjustmeetindustrystandardsbut pushthemforward.Byfocussingoninnovation,efficiencyandsustainability,Wilhelm isleadingtheconversationacrossAustraliaandNewZealand

ProfessorFionaWood

WinthropProfessorFionaWoodAOUniversityofWesternAustraliaisaPlastic& ReconstructiveSurgeonspecialisinginthefieldofburncare,traumaandscar reconstruction.

AsDirectoroftheBurnsServiceofWesternAustraliasince1991sheisconsultant surgeonatboththeSouthMetropolitanHeathService,FionaStanleyHospitaland theChildandAdolescentHealthService,PerthChildren’sHospital.

AsdirectorofBurnsInjuryResearchUnitsheleadsaninterdisciplinaryteamwith broadcollaborationfocusedontranslationtoimproveclinicaloutcomes

ShewasAustralianoftheyearin2005andsitsonanumberofboardsincludingthe RoyalFlyingDoctorService

ORALPRESENTATIONS

SamuelHandshin(presenter1,2,3),MaryIengo(1,2,3),TamaraCrittenden(1,2,)Phillipa vanEssen(1,2)AndreaSmallman(1),NicolaR Dean(1,2)

1 DepartmentofPlasticandReconstructiveSurgery,FlindersMedicalCentre,BedfordPark, Adelaide,SouthAustralia,Australia

2.CollegeofMedicineandPublicHealth,FlindersUniversity,BedfordPark,Adelaide,South Australia,Australia

3 Denotesjointfirstauthorship

Background:Facialskincancersandsurgicalmanagementcanalterappearance Thiscontributestopatient morbiditythrougheffectsonself-perceptionandpsychosocialwell-being Quantitativeassessmentofimpacts canbeundertakenusingapsychometricallyvalidatedpatient-reportedoutcomemeasure,theFACE-Qskin cancermodule.

Methods:Thisisasinglecentre,prospectivecohortstudyof110participantsundergoingfacialskincancer surgeryinanAustraliantertiaryhospitalbetweenNovember2021andDecember2023 Participantscompleted FACE-QSkinCancerquestionnairespre-operativelyandatone,three,six,and12monthspost-operatively.

Results:105participantscompletedpre-operativequestionnaires,ofthese,101(918%),96(873%),93 (845%)and76(691%)completedquestionnairespost-operativelyat1,3,6,and12months,respectively At12months,significantimprovements(p<0.001)werefoundinCancerWorry,AppraisalofScarsandSunProtection Behaviours Agewasfoundtobeasignificantpredictorofoutcomeacrossallscalesandchecklists(p<0001;p =0002)incomparisontoothervariables Beingunder65yearsofagesignificantlypredictedworseCancer Worry(p=002)andAppraisalofScars(p=004) CombinedrepairwasassociatedwithworseCancerWorry (p=0.03).TherewasnosignificantdifferencesinoutcomesobservedbetweenmelanomaandNMSC.

Conclusion:Facialskincancersurgeryimprovespatientreportedhealth-relatedqualityoflife,appearanceand sunprotectionbehaviours Youngerpatientsandthoserequiringreconstructivemanagementmaybenefitfrom targetedperi-operativesupportalongsideinterdisciplinarycare.ClinicalintegrationoftheFACE-QSkinCancer modulewillassisttreatingspecialiststoprovideindividualisedcaretopatients

ISROUTINEAXILLARYSTAGINGSTILLREQUIREDINCLINICALLYNODENEGATIVEEARLYBREASTCANCERIN WOMENOVER74YEARS?

KatherineGrant(presenter,1,2),JamesPo(3),LeongTiong(1)

1 DepartmentofSurgery,RoyalAdelaideHospital,Adelaide,SouthAustralia

2 UniversityofAdelaide,Adelaide,SouthAustralia

3.RoyalMelbourneHospital,Melbourne,Victoria

Introduction:Investigateincidenceandidentifypredictorsofaxillarylymphnodemetastasesinearlybreast cancerinwomen>74yearsAustraliaandNewZealandtoinformdecisionmakingaboutsentinellymphnode (SLN)biopsyinthispopulation

Method:RetrospectivereviewofinvasivebreastcancerinwomeninAustraliaandNewZealandbetween20102022usingBreastSurgANZQualityAuditDatabase.Dataincludedpatientdemographics,tumourcharacteristics, surgerytype,axillarynodalstatusandadjuvanttherapy.Descriptiveanalysisofincidenceofaxillarynodal metastasesanduseofadjuvanttherapyinvariouspatientandtumourgroupswasperformed,followedby statisticalanalysisusingmultivariatelogisticregressiontoidentifypredictorsofaxillarynodalpositivityand correlationbetweennodalstatusandprescriptionofadjuvanttherapy.

Results:Reviewof127,436casesofinvasivebreastcancer,17,599cases>74years Twothirdsoftheoverall populationandinthose>74yearswerenodenegative Inpatients>74yearswithgrade1-2,T1a-bcancers, ER+/HER2-withoutlymphovascularinvasion,94%werenodenegative.Patientage,tumoursize,gradeand biomarkerprofilecorrelatedwithaxillarynodalstatusandanalysisofadjuvanttherapyrevealedsignificant correlationbetweennodalstageandadjuvantradiotherapy,chemotherapyandendocrinetherapy

Conclusion:94%ofpatients>74yearswithT1a/b,ERpositiveHER2negativebreastcancerwithout lymphovascularinvasionwerenodenegative.Nodalstatussignificantlyinfluencesadjuvanttreatmentand therefore,werecommendcliniciansconsidertumourfactorsandpatientfitnessintheirdecisionmakingabout SLNbiopsyintheelderlypopulationwithhormonereceptorpositiveearlybreastcancer

DarrenLam(presenter1),ShaotingZhang(1,2),KylieYen-YiLim(1),HarrisonLiu(1), JefferyJiang(1),EldoPaul(2),SteuartRorke(3),BeenaKumar(3),SeanLim(1),Matthew Harper(1),KevinChu(1),JamesHuang(1),NeiroshanRajarubendra(1),PaulManohar(1), TrungPham(1),GideonBlecher(1),ScottDonnellan(1),WeranjaRanasinghe(1)

1.DepartmentofUrology,MonashHealth,Melbourne,Australia

2 FacultyofMedicine,NursingandHealthscience,MonashUniversity,Melbourne,Australia

3 DepartmentofAnatomicalPathology,MonashHealth,Melbourne,Australia

Introduction:Activesurveillance(AS)isthestandardofcareforpatientswithISUPGradeGroup(GG)1disease However,therearesomeconcernswithASinGG1patientswithaPI-RADS4/5lesiononmultiparametricMRI (mpMRI) TheaimofthisstudywastoevaluatediseaseupgradinginmenwithISUPGG1andPIRADS4-5lesions

Methods:ISUPGG1patientswithwhounderwentASatatertiaryinstitutionbetween2016and2023withMRIwere identified.AllpatientswereassessedviaPI-RADSversion2.1guidelines.Coxregressionwasusedtodetermine theassociationbetweenPI-RADS1-3and4-5cohortandtheirdiseaseupgradation

Results:Twohundredandtwenty-eightmenwithISUP1diseasewereincluded Ofthese,onehundredand thirty-five(57.6%)patientshadaPI-RADS4-5lesion,whilenighty-three(42.4%)patientshadPIRADS1-3lesions. Therewasasignificantdifferenceinmaximumlengthofpositivecores(p-value=0039),biopsyupgrading(pvalue=0017)andsubsequentradicalprostatectomy(p-value=002)betweenstudycohorts Onrepeatbiopsy, twenty-three(404%)menwithPIRADS1-3andforty-ninemen(583%)withPIRADS4-5wereupgradedto clinicallysignificantprostatecancer(p-value=0.04),withasignificantshortertimetodiseaseupgrading(pvalue=0001) Amongpatientsunderwentradicalprostatectomypostreclassification,154%(2/13)withPIRADS13had≥pT3disease,while477%(20/42)patientswithPIRADS4-5lesionhad≥pT3disease(p-value=009)

Conclusion:PI-RADS4-5patientsshowedahigherlikelihoodofbiopsyupgradingandsignificantlyshortertime todiseaseprogression ISUPGG1diseasewithPI-RADS4/5lesiononMRIwarrantscarefulAS

COMBINATIONOFHORMONALTHERAPYANDMITOCHONDRIAL-TARGETEDTHERAPYASANOVELSTRATEGYFOR BREASTCANCERTREATMENTINHUMANBREASTCANCERCELLLINES

MariaAhsan(Presenter,1),PhyuSynnOo(2),SaintNwayAye(2),Purushotham Krishnappa(2)

1 UniversityofNewSouthWales,Sydney,NewSouthWales,Australia

2 PathologyDepartment,SchoolofMedicine,InternationalMedicalUniversity,Kuala Lumpur,Malaysia

Background:Breastcanceristheleadingcauseofcancerdeathforwomenduetotreatmentresistanceof hormonaltherapyandmetastasis Mitochondriahaverecentlyemergedasintriguingtargetsforanticancer drugs.Mitochondriaundergoesdramaticchangesbyfissionandfusion,andDynamin-relatedprotein1(Drp1)is amajorfissionrelatedprotein Drp1phosphorylationatSer616,regulatedbyestrogenandERα,resultsinbreast cancerproliferation Mdivi-1,aDrp1inhibitor,blocksmitochondrialfission,leadingthecellsapoptosis Hence, combiningMdivi-1withhormonaltherapywillbeamoreeffectiveplanforER+breastcancerpatients

Methods:CellviabilityusingMTTassaywasperformedtodeterminetheeffectsofMdivi-1aloneandin combinationwithhormonaltherapyintheMCF7breastcancercellline Immunohistochemistrywasdoneto provethatcelldeathhappenedthroughapoptosis Studentpairedt-testwasusedforstatisticalanalysis

Results:After24hoursinMCF7cells,treatmentstartingfrom10μMMdivi-1showedsignificantcelldeath, comparedtocontrol Inboth48and72hours,significantcelldeathstartedinalowerconcentration(5μMMdivi1) ForMDA-MB-231cells,significantcelldeathwasfoundin25μMMdivi-1after48hours CombinedICI(1μM)and Mdivi-1(10μM)treatmentfor24hoursinducedsignificant,dose-dependentcelldeathinMCF7cellscompared toICIalone

Conclusion:Mdivi-1decreasedcellsurvivalandgrowthofER-positivebreastcancercellscomparedtoERnegativebreastcancercells.Itissuggestedthatcombinationtreatmentismoreeffectivethanhormonal therapyaloneinER-positivebreastcancercellsandmightbethefuturetreatment

MrJoshuaAndrews(presenter,1),MelanieAmarasooriya(2),SimonBellringer(3) GregoryIanBain(4)

FlindersMedicalCentreandFlindersUniversity,BedfordPark,SouthAustralia, Australia 1

2UniversityofMoratuwa,SriLanka

3UniversityHospitalsSussex,Brighton,UnitedKingdom .

4FlindersMedicalCentre,Adelaide,SouthAustralia,Australia

Background:Scapholunateinstability(SLI)isthemostcommonformofcarpalinstability,andwithout accuratediagnosticandsurgicaltechniques,degenerativeandarthriticchangeswilloccur.Surgicaland clinicaloutcomesforSLIremainsuboptimalinpartduetoalimitedconsensusontheroleeachligamentplays towardssupportingthecomplex.Wesystematicallyreviewedcadavericsectioningtoevaluatethestabilising roleofeachligament,andhowinstabilitypatternsarecreated

Methods:ThissystematicreviewemployedPRISMAguidelines,identifying30studiesspecimenswhichmetthe eligibilitycriteria,including376cadavericspecimens Thekeyoutcomemeasureswerescapholunategap (SLG),scapholunateangle(SLA),radiolunateangle(RLA)anddorsalintercalatedsegmentinstability(DISI)

Results:CadavericsectioningrevealedameanincreaseinSLG+20mm,SLA+88°andRLA+18°with sectioningofthescapholunateligament(SLIL) SequentialandcumulativesectioningoftheSLILand additionalligaments,showedthedorsalintercarpalligament(DIC)toproducethegreatestchangeinall outcomemeasures DISIwasinconsistentlyfoundwithsectioningoftheSLILandtheDICorSTT

Conclusions:TheSLIListheprimarystabiliseroftheSLintervalandinstabilitywillnotoccurifitremainsintact CumulativeandsequentialsectioningshowedtheDICtobethecriticalsecondarystabiliser,withtheSTT,RSC andLRLholdingalesserrole DISIwasnotconsistentlyproducedwithsectioning,suggestingthatitisa dynamicphenomenonthatcannotbeusedtoincludeorexcludeligamentousinjury.

EVALUATIONOFDEEPLEARNINGFORHIGHB-VALUEDIFFUSION-WEIGHTEDMRIINBONEANDSOFTTISSUE TUMOURASSESSMENT

StevenZhang(presenter,1)SaraAshtiani(2)EmilySquires(2)ShaneshKumar(3) KerolosHendy(4)AliceAndrawos(4)WanYinLim(3)MinhHieuPhan(6) StephanieWithey(7)AndrewDwyer(8)AngelaWalls(8)GanessanKichenadasse(9) SabaHatami(4)JakubJagiello(10)LukeJohnson(11)Minh-SonTo(2,4,6)

1 FacultyofHealthandMedicalSciences,UniversityofAdelaide,SouthAustralia

2 CollegeofMedicineandPublicHealth,FlindersUniversity,SouthAustralia

3 JoneRadiology,RoyalAdelaideHospital,SouthAustralia

Introduction:Magneticresonanceimaging(MRI)iscrucialinthepreoperativeassessmentofboneandsoft tissuetumours Diffusion-weightedimaging(DWI)estimatestumourcellularityandaggressiveness,andhighbvalueDWIprovidesgreatertumourconspicuity However,highb-valueDWIisnotwidelyavailable Thisstudy exploresthepotentialofdeeplearningforsynthesisinghighb-valueDWIforpre-operativeevaluation.

Methods:30adultpatientsplannedforsurgeryorbiopsyattheSouthAustralianSarcomaandBoneTumour Unitwererecruitedprospectively Deeplearningmodelsweretrainedonlowb-valueDWIandT2-weighted imageswithcross-validation. Performancemetrics includedlearnedperceptualimagepatchsimilarity(LPIPS), structuralsimilarityindexmeasure(SSIM),peaksignalnoiseratio(pSNR)andmeansquarederror(MSE) Synthesisqualitytogroundtruthwasassessedbyradiologistsviaa5-pointLikertscaleandpairwise comparisons StatisticalanalysisinvolvedpermutationtestingforsynthesisqualityandaFriedmantestwith posthocNemenyitestformodelranking.

Results:Thetop3performingmodelswereStochasticDifferentialEquations(SDE),Pix2PixTurbo,and DiscriminatorEdge-AwareGAN TheyachievedpSNR(257,245,256dB),SSIM(0764,0832,0849,range:0-1), LPIPS(0.262,0.0870,0.114,range:0-1)andMSE(0.00342,0.0170,0.00297,range:0-1).Likertscalefrom3 radiologistshadamodeof4andmedianof4,withpairwisecomparisonsindicatingpreferenceforSDE

Conclusions: Deeplearningshowpromiseinsynthesisinghighb-valueDWI/ADC,potentiallyenhancingpreoperativeevaluationofboneandsofttissuetumours.Futureworkaimstoincorporateanomalydetectionto improvetheidentificationofmalignantlesions

Jocelyn Lippey (presenter, 1, 2, 3), Louise Keogh (4), Stephanie Best (5), Ian Campbell (6),BruceMann(7),LauraForrest(3,8)

1 St Vincent'sHospital,DepartmentofSurgeryandAcademyofSurgeons,Fitzroy,Victoria 2.UniversityofMelbourne,DepartmentofSurgery,Carlton,Victoria 3 SirPeterMacCallumDepartmentofOncology,NorthMelbourne,Victoria

4 UniversityofMelbourne,MelbourneSchoolofPopulationandGlobalHealth,Parkville,Victoria

5 UniversityofMelbourne,Medicine,DentistryandHealthSciences,Parkville,Victoria

6.PeterMacCallumCancerCentre,CancerGeneticsLaboratory,NorthMelbourne,Victoria

7 RoyalMelbourneHospital,BreastService,Parkville,Victoria

8 PeterMacCallumCancerCentre,ParkvilleFamilialCancerCentre,NorthMelbourne,Victoria

Introduction:Riskbasedbreastcancerscreeningmovesawayfromourcurrentonesizefitsallmodeltoa tailoredapproachwerepeoplewouldhavedifferentscreeningmodalitiesandfrequenciesdependentontheir individualrisk

Thisprojectassesseswhatkeystakeholders,definedasthoseinpositionsofmanagementanddecision makingforBreastScreeninginAustralia,thinkofimplementingriskbasedscreening.

Method:Aqualitativeapproachwasundertaken,recruitingparticipantsthroughprofessionalnetworksand implementationframeworksdirectedinterviewguides.Thecodebookwasdevelopedforthematicand contentanalysisoftheinterviews.Codingwasdonebothdeductivelyandinductively.

Results:21participantswererecruitedand20interviewswereconducted 144initialcodeswereconsolidated into17barriersandenablers.Thesixenablersidentifiedwere:‘NationalBreastScreenreviewcurrently underway’,‘Organisationsmotivationtoimprove’,‘Theopportunityforimprovedhealthofanindividual’and ‘Improvedscreeningforall’ 11barrierswere‘Worseningthecurrentinequities’,‘Dichotomybetweenriskinan individualandriskforapopulation’,‘Current‘payperscreen’modeloffundingisnotcompatiblewithrisk basedscreening’,‘Heterogeneitybetweenjurisdictions’,‘BreastScreenisnotaresearchorganisation’, ‘Competingpriorities’,‘Healthliteracy’,‘Individualsperceptionformotivationofchange’,‘Costofriskbased screening’,‘Issueswithriskassessment’and‘Whatisoptimalscreeningfordifferentriskcategories?’

Conclusion:KeyStakeholdersaresupportiveandoptimisticaboutriskbasedscreeninginprinciplehowever severalbarriersandenablersexist.Systematicassessmentofthesefactorsareneededinplanningand implementationofachangetotheprogram

CHRONICRENALFAILUREASAPREDICTOROFPOSTOPERATIVEMORBIDITYANDSURVIVALINCOLORECTAL CANCERSURGERY:ARETROSPECTIVEMULTICENTERANALYSIS

MrYajatDua(presenter,1),DrArthavanSurendran(1),DrSimonWilkins(1,2),ProfMohammad Asghari-Jafarabadi(3,4,5),JohnPaulPlazzer(1),MrRaymondYap(1),ProfPaulMcMurrick(1)

1 CabriniMonashUniversityDepartmentofSurgery,CabriniHospital,Malvern,VIC,Australia

2.DepartmentofBiochemistryandMolecularBiology,MonashUniversity,Melbourne,VIC, Australia

3 CabriniResearch,CabriniHospital,Malvern,VIC,Australia

4 SchoolofPublicHealthandPreventiveMedicine,MonashUniversity,Melbourne,VIC,Australia

5.DepartmentofPsychiatry,SchoolofClinicalSciences,MonashUniversity,Clayton,VIC,Australia

Background:Therisingprevalenceofcolorectalcancer(CRC)andchronicrenalfailure(CRF)duetoanaging populationposeschallengesintheperioperativemanagementofCRCsurgerypatients Theimpactofrenal functiononpostoperativeoutcomesremainscontroversial,withlimiteddataavailableontheirassociationwith morbidityandmortality

Methods:Aretrospectiveanalysiswasconductedusingahigh-quality,prospectivelymaintainedcolorectal neoplasiadatabasefrommultiplehospitalsinAustralia 2,286patientswhounderwentCRCsurgerybetween2010 and2023werecategorizedbasedonclinicallydeterminedCRFstatusandpreoperativeeGFRlevels,with comprehensivedataondemographics,comorbidities,surgicaldetails,andbothshort-termandlong-term outcomes MultivariablelogisticandCoxproportionalhazardsregressionanalyseswereusedtoexaminethe associationsbetweenCRF,eGFR,andpostoperativeoutcomes,includingcomplications,30-daymortality,overall survival(OS),andrelapse-freesurvival(RFS)

Results:CRF,presentin135patients(59%),wasindependentlyassociatedwithincreasedriskofpostoperative complications,30-daymortality,andprolongedileus CRFsignificantlyreducedOS(AHR:149,p<0001)andRFS (AHR:151,p<0001),with5-yearOSandRFSratesof589%and574%,respectively,comparedto833%and827%in non-CRFpatients. Incontrast,preoperativeeGFR<60mL/min/1.73m²wassignificantlyassociatedwithmedical complicationsand30-daymortalityinunivariateanalysisbutlostsignificanceinmultivariableanalysis

Conclusion:CRF,definedbypersistentserumcreatinineelevation,isastrongpredictorofincreasedperioperative morbidityandreducedlong-termsurvivalinCRCsurgerypatients Comprehensivepreoperativerenalfunction assessmentisessentialforoptimizingsurgicaloutcomesinthispopulation

DrJackMenzie(Presenter,1),DrAmosLiew (1),DrVanishaFernando(1)DrAnderson Cheong(1),DrLuluXiao(1),DrNicholasKing(1),DrYigengLi(1),DrAshrayRajagopalan (1,3),MsGeraldineOoi(1,2,3)

1.DepartmentofGeneralSurgeryMonashHealth,ClaytonVIC,Australia

2 DepartmentofUpperGastrointestinalandHepatobiliarySurgeryMonashHealth, ClaytonVIC,Australia

3 SchoolforClinicalSciencesatMonashUniversity,ClaytonVIC,Australia

Backgrounds:EvidenceshowsthathighBMIcontributestoincreasedpost-operativecomplicationsin gastrointestinalsurgeriesandsuggeststhatitmaycontributetointraoperativeadverseeventsduetotechnical difficulties.WeaimedtodetermineifahighBMIresultsinincreasedintraoperativeadverseevents(ClassIntra classificationsystem)comparingliverresectionoutcomesinthosewithahighBMIwithnormal/lowBMI patients

Methods:AretrospectiveauditofalltypeliverresectionsperformedunderanadultHepatobiliaryunitat MonashHealthVictoriafromFebruary2018toOctober2023.WecomparedBMIgroupsandtheirimpacton intraoperativeadverseeventsandpost-operativecomplications

Results:203patientswereincludedintheanalyses.AhigherBMIacrossalltypesofliverresectionsdidnotshow anincreaseinpost-operativecomplicationsaccordingtoClavien-Dindoclassification.Therewasagreater lengthofoperationtimeinHighBMIpatients(2335minsBMI<25,2594minsBMI20-25,277minsBMI>30;p=0047) IntraoperativeadverseeventswereincreasedinhigherBMIpatientscomparedtonormal/lowBMIformajorliver resectionssuchasmultiplesegmentresectionsandhemi-hepatectomies(p=0.039).Bloodlossintraoperatively wasincreasedinhighBMIpatients(BMI<25=655ml,BMI25-30=543.3ml,BMI>30=836.6ml;p=0.017)

Conclusion:IncreasedintraoperativeadverseeventsbymeasureofClassIntraclassificationmaybe associatedwithanincreaseinBMIinpatientswhoundergomajorliverresections.Additionally,highBMIshows thatthereisnoincreaseinpost-operativecomplicationsandmaybeaprotectivefactorasoutlinedinother studies,howeverfurtherstudiesareneededtoclarifythisphenomenon

PATIENTANDCLINICIANPRIORITIESINPERIPHERALARTERYDISEASEMANAGEMENTUSINGMULTIPLECRITERIA DECISIONANALYSIS

NimaIranpour(Presenter1),RiteshChimoriya(1,2),SarahAitken(1,2)

1 ConcordRepatriationandGeneralHospital,Sydney,NewSouthWales

2.SpecialtyofSurgery,UniversityofSydney,NewSouthWales

Purpose:Healthcaredecisionsofteninvolvecomplextrade-offsbetweenmultiple,oftenconflicting,objectives MultipleCriteriaDecisionAnalysis(MCDA)offersastructuredandtransparentmethodologythatcanimprove decision-makingqualitybyconsideringabroaderrangeoffactorsbeyondtraditionalcost-effectiveness metricsThisstudyaimedtoassessthefeasibilityandvalueofusingMCDAtoestimatetherelativeimportance ofvariousaspectsofmultidisciplinaryperipheralarterydisease(PAD)managementfromtheperspectivesof bothpatientsandclinicians.

Methodology:ApilotMCDAquestionnairewasdevelopedtoevaluateanrandomisedcontrolledtrialcomparing multidisciplinaryteammanagementtousualcaretoreducecardiovascularrisksinpatientswithPAD Twenty twopatientsandcarersidentifiedoutcomesofimportanceinfocusgroupsandsurveys.Threeclinicians completedaSheffieldElicitationFramework(SHELF)activitytoweightoutcomesofinterestusinganAnalytical HierarchyProcess(AHP) ThefinalMCDAtoolwaspilotedintheconsumergroup,andresultsanalysed accordingtoISPORguidelines,refiningtheMCDAtoolbeforebroaderdeployment

Withdrawn

Results:Consumersprioritisedoutcomessuchas'PainManagement,''AccesstoOtherMedicalTreatment,' 'ImpactonQualityofLife,''SharedDecisionMaking,''EarlyDiagnosis,''AmputationPrevention,'and'Decreased RiskofHeartAttackorStroke'TheMCDAwasseenaspracticalandusefulincapturingdiversepriorities

Conclusion:MCDAshowspromiseasanoveltoolforevaluatingthevalueofamultidisciplinaryapproachto PADmanagement Thepilotstudysuccessfullydemonstratedthepracticalityofthisapproach,andtherefined toolisreadyfordeploymenttoalargergrouptofurthervalidateitseffectiveness

ChenLiu(presenter,1,2),EmmaLudlow(1),KaiShengSaw(1),CeliaKeane(1),Sherry Nisbet(2),SirajRajaratnam(2),JohnWoodfield(3),GregoryO'Grady(1),IanBisset(1)

1 DepartmentofSurgery,UniversityofAuckland,Auckland,NewZealand 2 TeWhatuOraWaitemata,Auckland,NewZealand

3.TeWhatuOraSouthland,Dunedin,NewZealand

Introduction:Thestudyaimedtoassesswhetherpre-operativechymereinfusionusinganovelmedicaldevice (TheInsides®System)reducedpost-operativelengthofstayfollowingloopileostomyreversal

Method:Thiswasamulti-centreRCTincludingpatientswithpreviousloopileostomyformationduringdistal colorectalanastomosis Beforeenrolment,anastomoticleakwasexcluded Patientswererandomisedto standardcare(controlgroup)ordailychymereinfusionusingthedevice(interventiongroup)foraminimumof 2weeksbeforeileostomyreversal.Theprimaryoutcomewasthepost-operativelengthofstay(LOS)following ileostomyreversal

Results:ThetrialwasperformedbetweenJune2020andMarch2023atsixhospitalsacrossNewZealand A totalof50patientswererandomised(26intheinterventiongroupand24inthecontrolgroup).Baseline characteristicsweresimilar Therewasnosignificantdifferenceinthemedianpost-operativeLOSbetween interventionandcontrolgroups:30(IQR2-5)vs40(3-5)days,respectively(p=0347) Intheinterventiongroup, 16patients(62%)didnotachievetwoweeksofchymereinfusionimmediatelypriortoileostomyreversal The mostcommonreasonwasdevicedislodgement(9/16).Interventiongrouppatientshadasignificantlyhigher mediannumberofunplannedoutpatientvisits:15(00-23)vs00(00-00),p<0001 Themostcommonreason forsuchvisitsintheinterventiongroupwasfordevicedislodgement Allothersecondaryoutcomesweresimilar

Conclusion:Chymereinfusionpriortoloopileostomyreversaldidnotreducepost-operativeLOS.Resultswere impactedbylowinterventioncompliancedemonstratingthatfurtherdeviceinnovationisrequiredinthis population

THEECONOMICANDENVIRONMENTALFOOTPRINTOFPRECISIONPOINTPROSTATEBIOPSIES

KylieLim(presenter,1,2),ShayanSoroush(2),LiangQu(1),AnthonyDat(1),Matthew Harper(1),ScottDonnellan(1),WeranjaRanasinghe(1,2)

1.MonashHealth,Melbourne,Victoria

2 MonashUniversity,Melbourne,Victoria

Introduction:DelaystoprostatecancercarehasbeenaffectedbytheCOVID19pandemic,addingtowaitlist pressuresandrequiresinnovativeandsustainablestrategies.OurVictorianinstitutionhasintroduced PrecisionPoint™TransperinealAccessSystem(PPTAS)–anoveldevicewhichcanbeperformedasan outpatientprocedureunderlocalanaesthetic(LA) Theaimswere1)toassessthesafetyandtodeterminethe potential2)economicand3)environmentalimpactofPPTAS

Methods:PPTASwasprospectivelyevaluatedundergeneralanaesthesiatoassessprostatecancerdetection andcomplicationsratescomparedtostandardtemplatebiopsyin2022 Basedoncurrentwaitlists,theatre expendituresanddisposablewastagewasmodelled

Results:34and106patientsunderwentPPTASandstandardtemplatebiopsyrespectively,withsimilar clinicallysignificantcancerdetectionrates(50%vs 538%) NocomplicationswererecordedinthePPTAS cohort CostsanalysiswhentransitionedtoLApredictsavingsof$718percase,totalling$236,900perannum Theatretimesavingsofapproximately17minutespercaseallowsadditionoftwobiopsiespersession. Furthermore,relocationtooutpatientsenablesavailabilityofanaestheticservicesandmaintheatreusefor otherelectiveoremergencyoperations Disposablewastegeneratedwoulddecreaseby818gramsper biopsycase,preventing270kgoflandfillwasteperannum

Conclusion:Comparablecancerdetectionratesweredemonstrated,assuringthesafetyofPPTAS The predictedanalysissuggeststhisdevicewillhavepositiveeffectsofreducingouroverburdenedsurgicaland clinicwaitlist Therearealsoanticipatedfinancialbenefitsandimprovementstosustainabilityimpactswith greateruseofexistingresources.

JosipaPetric(presenter,1),MuktarAhmed(1),MaziarNavidi(2),DavidPilcher(3), ShaileshBihari(1,4),NormaBBulamu(1),TimBright(1,2),DavidIWatson(1,2)

1.FlindersHealthandMedicalResearchInstituteandCollegeofMedicineandPublic Health,FlindersUniversity,SouthAustralia,Australia

2 DepartmentofSurgery,FlindersMedicalCentre,SouthAustralia,Australia

3 DepartmentofIntensiveCare,AlfredHealth,Victoria,Australia

4 IntensiveandCriticalCareUnit,FlindersMedicalCentre,SouthAustralia,Australia

Introduction:Arelationshipbetweenhospitalvolumeandmortalityfollowingoesophagectomyforcancerhas beenreportedacrossEuropeandUSAandledtocentralisationofsurgeryinsomecountries However,itis unclearifthisshouldalsooccurincountrieswithlowpopulationdensitysuchasANZ Ouraimwasto determinetherelationshipbetweenhospitalvolumeandmortalityoutcomefollowingoesophagectomyfor cancerinAustraliaandNewZealand(ANZ).

Methods:AsthestandardofcarefollowingoesophagectomyinANZisadmissiontoanintensivecareunit (ICU),theANZIntensiveCareSocietyAdultPatientDatabasewasusedtoidentifypatientsundergoing oesophagectomyfrom2005-22.Mortalityvshospitalvolumeascontinuousvariableswasinvestigated. Mortalitywasalsodeterminedforhospitalswithannualcaseloadsdefinedashigh(18+),medium-high(12-17), medium-low(6-11)andlow(1–5).

Results:6234patientsunderwentoesophagectomyin161hospitals.Overallin-hospitalmortalitywas3.78%, decliningto073%inhighvolumehospitals Twenty-fivepercentofprocedureswereperformedinlow-volume hospitals(n=1558),and199%inhigh-volumehospitals(n=1239) Highvolumehospitalsalsohadshorter lengthofstayinhospital(p<0001)andinICU(p<0001) Theminimumannualhospitalvolumeforthelowest mortalitywas16-21casesperyear Ifallhospitalsperformedatleast16casesperyear,onedeathforevery 200oesophagectomiescouldbeprevented

Conclusions:Apositivevolume-outcomerelationshipforANZwasdemonstratedformortalityfollowing oesophagectomy,withhospitalsperforming16ormoresurgeriesperyeardeliveringlowestmortality

DEFINING‘FAILURETORESCUE’AFTERPOSTOPERATIVECOMPLICATIONS:ASYSTEMATICREVIEWAND POPULATION-BASEDSTUDY

CameronWells(presenter,1,2),WilliamXu(1,3),ChrisVarghese(1,4),SameerBhat(1,5), GregO’Grady(1),ChrisHarmston(1,6),IanPBissett(1,3)

1 UniversityofAuckland,Auckland,NewZealand

2 TeWhatuOraTeMatauaMaui,Hastings,NewZealand

3.TeWhatuOraTeTokaTumai,Auckland,NewZealand

4 TeWhatuOraWaitemata,Auckland,NewZealand

5 TeWhatuOraMidCentral,PalmerstonNorth,NewZealand

6 TeWhatuOraTeTaiTokerau,Whangarei,NewZealand

Background:Failuretorescue(FTR)isthedeathrateamongstpatientswithpostoperativecomplications,andis asurgicalqualityindicator.However,FTRhasbeendefinedinconsistently,withpotentialimpactsonreported ratesandhospitalrankings

Methods:DatabasesweresystematicallysearchedforstudiesreportingpostoperativeFTRrates Weexamined thecomplicationsincludedintheFTRdenominator,thepercentageofalldeathscapturedbyFTR,andthe timingofmeasurementforbothcomplicationsandmortality FiveFTRdefinitionsadaptedfromtheliterature wereexaminedinaNewZealandcohortofgastrointestinalandhepatobiliarycancerresectionsfrom20052020 Hospitalrankingswerecomparedusingrisk-adjustedFTRrates

Results:Intotal,359studiesincluding212,048,069patientswerereviewed Themediannumberofcomplications includedintheFTRdenominatorwas10(IQR8-15),but131differentcomplicationswerereported Studieswhich includedmorecomplicationsintheFTRdenominatortendedtoreportlowerFTRrates Complications(52%)and mortality(40%)weremostcommonlymeasuredin-hospital,followedby30-daysaftersurgery. Forthe population-basedstudy,31,199patientswereincludedTheempiric90-dayFTRratevarieddependingonthe definitionused,rangingfrom104-187% Hospitalrankingswereaffectedbytheboththedefinitionandtimingof outcomemeasurement

Conclusion:FTRisanimportantconceptinsurgicaloutcomesresearch,althoughitsdefinitionishighlyvariable andpoorlyreportedintheliterature ThecomplicationsintheFTRdefinitionandthetimingofoutcome measurementmayimpactresults ThishasimportantramificationsforFTRasaqualityindicatorwhen comparinginstitutionalperformance.

DrMathewAmprayil(presenter,1),TanyaIrvine(1),A/ProfSarahThompson(1),DrTim Bright(1,2),ProfDavidWatson(1,2)

1 FlindersUniversity,Adelaide,SouthAustralia

2 DivisionofSurgery,FlindersMedicalCentre,BedfordPark,SouthAustralia

Background: Obesityisasignificantriskfactorfordevelopmentoflargehiatushernias(LHH).Patientsareoften symptomaticandexperiencepoorqualityoflife Laparoscopicrepairoffersexcellentclinicaloutcomes However,surgeonsmaybereluctanttoofferoperativerepairintheobesepopulationduetoconcernsofhernia recurrenceandincreasedsurgicalmorbidityandmortality Thisstudydeterminedtheperioperativeriskand short-termclinicaloutcomesfollowingLHHsurgeryintheobesepopulation.

Methods:Datawasextractedfromaprospectivelymaintaineddatabase Patientswhounderwentsurgical repairofLHH(definedas>50%intrathoracicstomach)between2000and2023wereincludedandcatergorised into3groups;Normal(BMI<30),Obese(30–34),MorbidlyObese(>35).

Results:920patientsunderwentelectiverepairofLHH(BMI<30:524[570%];BMI30–34:276[30%];BMI>35:120 [130%])wereincluded Obesepatientswereyounger(691vs657vs64years,p<0001) Lengthofstay(28vs 2.5vs2.6days,p=0.06),majorcomplicationsrates(4.1vs2.6vs1.7%,p=0.301),returntotheatre(2.9vs1.1vs 17%,p=0241),30-day(02vs04vs0%,p=0761)and90-daymortality(04vs04vs0%,p=0797)didnot differ Therewasasignificantandsimilarimprovementinsymptomsandoverallsatisfaction

Conclusion:LaparoscopicrepairofLHHintheobeseisassociatedwithlowperioperativeriskandsignificant improvementinsymptomsandsatisfaction Surgeryshouldnotbewithheldfromthesegroups

NON-TECHNICALERRORSASSOCIATEDWITHADVERSEEVENTSINTHEAUSTRALIANSURGICALPOPULATION:AN EIGHT-YEARRETROSPECTIVEANALYSIS

JesseEy(presenter,1),VictoriaKollias(1),OctaviaLee(1),KellyHou(1),Matheesha Herath(1),EllieTreloar(1),MartinBruening(1),AdamWells(2),GuyMaddern(1)

1 DepartmentofSurgery,TheUniversityofAdelaide,TheQueenElizabethHospital, Woodville,SouthAustralia

2 DepartmentofNeurosurgery,TheRoyalAdelaideHospital,Adelaide,SouthAustralia

Introduction:Manyadverseeventsinsurgeryarecausedbyfailingsofnon-technicalskills(NTS) Theincidence andcharacteristicsofnon-technicalerrorsinAustraliaispoorlyunderstood,therefore,evidencetoguideNTS improvementactivitiesislacking.Thisstudyaimedtoinvestigatetheincidence,andcharacteristicsofnontechnicalerrorsassociatedwithadverseevents,leadingtomortalityinAustralia

Methods:AllsurgicalmortalitycasesreportedtotheAustralianandNewZealandAuditofSurgicalMortality (ANZASM)between2012-2019,withanadverseeventorareaforconcernwereincluded.Caseswere retrospectivelyassessedusinganoveltool,developedandvalidatedbythestudyauthors Primaryoutcomes includedincidenceofnon-technicalerrorsoverallandbyNTS-domaintype(Communication/Teamwork, DecisionMaking,SituationalAwareness,Leadership) Asecondaryoutcomewaschangeinnon-technicalerrors overtime.Caseswereassessedbytwoindependentassessorswithdisagreementsresolvedbyathird.

Results:Of3695casesassessed,637%hadnon-technicalerrorsassociatedwithpatientmortality Ofthese, 5841%hadDecision-Makingerrors,5642%hadSituationalAwarenesserrors,1517%had Communication/Teamworkerrors,and5.44%hadLeadershiperrors.Incidenceofnon-technicalerrors decreasedsignificantlybetween2012-2019(meandifference=-189,95%CI:-289,-090,P=00002) Statistically significantdecreasesbetween2012-2019weredemonstratedforCommunication/Teamworkerrors(mean difference=-002,95%CI:-003,-000,P=00092)andLeadershiperrors(meandifference=-055, 95%CI:-1.06,-0.04,P=0.0358).NosignificantchangesinDecisionMakingorSituationalAwarenesserrorswere demonstrated

Conclusion:Theincidenceofnon-technicalerrorsassociatedwithsurgicalmortalityinAustraliaishigh Future NTSimprovementeffortsneedtobetargetedtowardsDecisionMakingandSituationalAwareness.

EllieTreloar,MatheeshaHerath,MerylAltree,SamPotter,DavidWalsh,LaurenKennedy, MatthewPenhall,JesseEy,SuzanneEdwards,MartinBruening,GuyMaddern

1 UniversityofAdelaide,Adelaide,SouthAustralia

2 Women’sandChildren’sHospital,Adelaide,SouthAustralia

3.SchoolofMedicine,UniversityofSydney,Sydney,NewSouthWales

Introduction: Ward-roundqualitydirectlyimpactspatientoutcomesandpoorconductisassociatedwith increasedratesofpreventableadverseevents.Despitethis,thereisminimalliteratureinformingbestpractice inthewardround Theaviationindustryhasbeensuccessfulinmitigatinghumanerrorusinga‘SterileCockpit’ toreduceinterruptionsandnon-essentialactivities Theaimofthisstudywastoimprovepatientoutcomes, satisfaction,anddocumentationofcareusinga‘SterileCockpit’interventioninthewardround

Methodology: Thiswasapre-postinterventionstudywherebysurgicalwardroundswereaudio-visually recorded The‘SterileCockpit’isaprotectedvirtualzoneensuringnointerruptionsandparallelconversations occur Itinvolvesallocatingteamroles,thescriberepeatingtheplan,andclarificationofdocumentation The primaryoutcomeswereaccuracyofdocumentation,patientsatisfaction,interruptionsandtimeatbedside.

Results:Atotalof141wardroundencounterswererecorded,taking232s(pre)and271s(post) Thepatient satisfactionsurveyhadaresponserateof957% The‘SterileCockpit’interventionimprovednursepresence (45%-69%),improvedtheverificationofpatient’splan(1%-91%)andreducedparallelconversation(66%-27%). Additionaldataanalysisiscurrentlybeingconductedbyanexternalstatistician.

Conclusions:The‘SterileCockpit’givesstaffamomentto“breathe”,slowdown,reflect,doublecheckpatients plan,andgivesjuniorstaffpermissiontospeakup.Byaddressingthe‘hurry-upsyndrome’(causeof80%of clinicalincidents)withastructuralchangethatdoesnotsignificantlyincreasethetimetaken,therewillbe lesspreventableerrorandbetterpatientoutcomes

SamwelMakanyengo(presenter,1,2,3),EmilyC Hoedt(2,3),BridieGoggins(2,3), StephenSmith(1,4),PeterPockney(3),SimonKeely(2,3)

1 DepartmentofSurgery,JohnHunterHospital,Newcastle,Australia

2 SchoolofBiomedicalSciences&Pharmacy,CollegeofHealth,Medicineand Wellbeing,UniversityofNewcastle,Newcastle,Australia

3.HunterMedicalResearchInstitute,ImmuneHealthProgram,NewLambtonHeights, NSW,Australia

4 SchoolofMedicineandPublicHealth,CollegeofHealth,MedicineandWellbeing, UniversityofNewcastle,Newcastle,Australia

Introduction:Theevidencefortheimpactoforalantibioticsonanastomotichealingisweakdueto considerableheterogeneityinantibioticregimensandroutesofadministration.Wesoughttoinvestigatethe impactthatantibioticusehasonthegutmicrobiomeinrelationtoanastomoticinamousemodelofcolonic resectionandanastomosis(R&A)

Methods:24miceunderwentR&Aeitherwithneomycin,100mg/kgdilutedto1mg/100ul,byoralgavage1day prior(Abx,n=12)orwithequivalentvolumesterilewater,given1dayprior(H2O,n=12) Endpointsweredoneat day3 Microbiomeanalysisofmucosalsamplesby16SrRNAsequencing Lineardiscriminantanalysis(LDA) effectsize(LEfSe)wasusedtoperformhighdimensionalclasscomparisons

Results:3miceintheH2OgroupdevelopedleakscomparedtooneintheAbxgroup Asignificantdifferencein alphadiversitywasobservedinthepost-operativesamplesatday3withincreaseddiversityintheH2Ogroup (Chao1p=00049) Themostabundantbacteriaintheantibioticgroupfromintra-operativesampleswas Bacteroides.ThisshiftedtoBlautia,Muribaculum,Robinsoniella,Anaerotruncus,Enterococcus,andTuricibacter atday3 ThemostabundantbacteriaintheH2Ogroupintra-operativelywereDubosiellaandCoriobacteriales Atday3thisshiftedtomembersofthefamilyLachnospiraceae

Conclusions:Ourfindingssuggestthatpre-operativeantibioticsalterthemicrobiomeinawaythatmitigates proliferationofvirulentspeciesthataffectanastomotichealing BacteriafromthefamilyLachnospiraceaewere demonstratedinahumanstudytobeabundantinpatientswhodevelopanastomoticleaks

AnshiniJain(presenter,1,2),MichaelPFlood(1,2),GlenGuerra(1,2),HelenMohan,(1,2), SatishWarrier(1,2)JosephCHKong(1,2)MichaelMichael(1,3),RobertRamsay(1,2), AlexanderGHeriot(1,2)

1.DepartmentofSurgicalOncology,PeterMacCallumCancerCentre

2 SirPeterMacCallumDepartmentofOncology,UniversityofMelbourne

3.DepartmentofMedicalOncology,PeterMacCallumCancerCentre

Introduction:ColorectalPeritonealMetastases(CPM)developin13%ofCRCpatients,however,asubsetof patientscanbeofferedCytoreductiveSurgery(CRS)withHyperthermicintraperitonealchemotherapy(HIPEC), withfavourablemediansurvivalof40months,comparedto16monthsonsystemic-therapyalone PRODIGE-7 hasquestionedtheefficacyofHIPEC,demonstratingnosurvivalbenefitofCRS+OX-HIPECwhencomparedto CRSalone,creatingclinicalequipoiseinthemanagementofCPM

Method:PredictORGisanoveltranslationalstudythatidentifiesthebestHIPECdrugforindividualpatients basedonin-vitrosensitivitydemonstratedbypatient-derivedorganoids Intra-operativeCPM-biopsieswere collectedfromthreeinterstateperitonectomycentres(RPAH,TQEHandPMCC)andtransportedtoPMCCfor tissueprocessing,organoidcultivation,anddrugscreening Patients’organoidswereincubatedfor4days andexposedtoMitomycin-C/OX/IRIasmonotherapy.Amachinelearningalgorithmwasdevelopedto identifyorganoidviabilityuniquetoeachpatient’sorganoidphenotype

Results:Acrossthethreesites,27patientswererecruitedandanoverallorganoidsuccessratewas77% (14/18).Themeantimetosuccessfulorganoidcultivationwas17.8(8-34)daysandtimedrugassayresult 248(15-41)days Successratesdidnotdifferbetweenlocalandinterstatesamples(PMCC(6/8)75%; RPAH(6/8)75%;TQEH(2/2)100%)

Conclusion:Thisnoveltranslationalstudydemonstratesthatmulticentretissueretrieval,organoidcultivation anddrugscreeningisfeasiblewithinthe4-weekperiodthatpatientsareoptimisedfortheirdefinitiveCRSand HIPEC ThereisconsensusfromallAustralianperitonectomycentrestoproceedtoafundednationwide translationalclinicaltrialinvestigatingtheimprovementinoncologicaloutcomesutilisingthistranslational, personalisedmedicineapproach

NicoleLYTham(presenter,1,6),FionaReid(1,5),RosemaryCarroll(1),StephenRSmith (1,2,3,4)

1 ColorectalUnit,DepartmentofSurgery,JohnHunterHospital,Newcastle,NewSouth Wales,Australia

2 HunterMedicalResearchInstitute,Newcastle,NewSouthWales,Australia

3.SchoolofMedicineandPublicHealth,UniversityofNewcastle,NewSouthWales,Australia

4 DepartmentofSurgery,CalvaryMaterHospital,Newcastle,NewSouthWales,Australia

5 ColorectalUnit,DepartmentofSurgery,FootscrayHospital,Footscray,Victoria,Australia

6.ColorectalUnit,DepartmentofSurgery,StVincent'sHospital,Fitzroy,Victoria,Australia

Introduction:Lignocaineisusedinopioid-sparingmultimodalanalgesia,withpotentialoncologicbenefitvia immunomodulation.However,itsoptimumdosingandadministrationrouteisstilluncertain;whiletoxicityisrare itispotentiallysevere Thisstudyaimstoassessplasmalignocainelevelsinpatientswhohadlaparoscopic colorectalcancer(CRC)resectionsurgery,duringintra-operativeintravenous(IV)infusionandpost-operative regionalabdominalwallblocks

Methods:Thiswasaprospectivecohortstudy,usingasubsetofdatafromtheLignocaineInfusioninColorectal NeoplasiaPatientImmuneCells(LICPIC)study;adouble-blind,randomisedcontrolledtrialinvestigatingeffect oflignocaineonimmunefunction AdultpatientsundergoinglaparoscopicCRCsurgerywereincluded(20182022).PatientsreceivedIVinfusionofstudydrug(lignocainev.placebo)intra-operatively,followedbyregional infusionviatransversusabdominisplane(TAP)catheterfor3dayspost-operatively Participantshadblood samplescollectedat6timepointstomeasureplasmalignocainelevels

Results:Atotalof43patients(22lignocaine,21placebo)werestudied.Plasmalignocaineconcentrationsinthe lignocainegroupwerehigherwhenreceivingregionalinfusioncomparedtowhenreceivingIVlignocaine MedianplasmalignocainelevelswhilereceivinglignocaineviaTAPcatheterswereabove5µgml-1,whereas medianplasmalignocainelevelswhilereceivinglignocaineIVwerebelow5µgml-1 Notoxicitysideeffects wererecorded.

Conclusion:Thisstudysuggestsregionalinfusionoflignocainemayleadtosystemicabsorptionwithplasma lignocainelevelsreachingthepotentialforneurotoxicsymptoms(above5µgml-1),doseadjustmentorcloser monitoringmayberequired.

POSTERPRESENTATIONS

Session1

USEOFGENERATIVEARTIFICIALINTELLIGENCEINSURGICALEDUCATION

LavinaRao(1),EricYang(presenter,1,2), SavannahDissanayake(1),RobertoCuomo (3),IshithSeth(1,2),WarrenM Rozen(1,2)

1 DepartmentofMedicineandSurgery,MonashUniversity,Melbourne, Victoria,3168,Australia

2 DepartmentofPlasticandReconstructiveSurgery,PeninsulaHealth, Melbourne,Victoria,3199,Australia

3 DepartmentofMedicine,PlasticSurgeryandNeuroscience,University ofSiena,Siena,53100,Italy

Theintroductionofgenerativeartificialintelligence(AI)has revolutionisedhealthcareandeducation TheseAIsystems,trainedon vastdatasetsusingadvancedmachinelearning(ML)techniquesand largelanguagemodels(LLMs),cangeneratetext,images,andvideos, offeringnewavenuesforenhancingsurgicaleducation Theirabilityto produceinteractivelearningresources,proceduralguidance,and feedbackpost-virtualsimulationsmakesthemvaluableineducating surgicaltrainees However,technicalchallengessuchasdataquality issues,inaccuracies,anduncertaintiesaroundmodelinterpretability remainbarrierstowidespreadadoption Thisreviewexploresthe integrationofgenerativeAIintosurgicaltraining,assessingits potentialtoenhancelearningandteachingmethodologies While generativeAIhasdemonstratedpromiseforimprovingsurgical education,itsintegrationmustbeapproachedcautiously,ensuringAI inputisbalancedwithtraditionalsupervisionandmentorshipfrom experiencedsurgeons GiventhatgenerativeAImodelsarenotyet suitableasstandalonetools,ablendedlearningapproachthat integratesAIcapabilitieswithconventionaleducationalstrategies shouldbeadopted Thereviewalsoaddresseslimitationsand challenges,emphasisingtheneedformorerobustresearchon differentAImodelsandtheirapplicationsacrossvarioussurgical subspecialties Thelackofstandardisedframeworksandtoolsto assessthequalityofAIoutputsinsurgicaleducationnecessitates rigorousoversighttoensureaccuracyandreliabilityintraining settings ByevaluatingthecurrentstateofgenerativeAIinsurgical education,thisnarrativereviewhighlightsthepotentialforfuture innovationandresearch,encouragingongoingexplorationofAIin enhancingsurgicaleducationandtraining

THEIMPACTOFFORMALTEACHINGINRESEARCHMETHODS AFTERPRIMARYMEDICALQUALIFICATIONSONSURGICAL RESEARCH:ANANALYSISOFSHORT-TERMRESEARCHOUTPUT

MeetPatel(presenter,1),DavidSun(1),Dominic Edwards(1),DhavalSolanki(1),JeetUpadhyay (1),ArjunRaju(1),MayaStarr(1),Thomas Maouris(1),AlexanderLombardo(1),Daphne Wang(1),KaramveerNagi(1),NazimBhimani (1),AnthonyGlover(1)

1 FacultyofMedicineandHealth,TheUniversityofSydney, CamperdownNSW2050,Australia

Introduction:Surgicalresearchhasbeenhistoricallycritiquedfor high-volumeandlow-clinicalapplicabilityyetremainscrucialfor modernsurgeons TheUniversityofSydneyMasterofSurgery(MS) programoffersformalteachingonresearchmethods,withan optiontocompleteadissertation Wesoughttoevaluatetheimpact ofresearchmethodsubjects(RMS)andsupervisorcharacteristics ondissertationqualityandshort-termresearchoutput

Methods:StudentsenrolledinthedissertationfortheUSYDMS programbetween2010-2020wereidentifiedandgradesforthe dissertationandRMSwereextracted PubMedandWebofScience wereusedtodetermineifthedissertationwaspublishedand identifyotherpublications Statisticalanalysisinvolvedlogistic regressionandnegativebinomialregression

Results:Ofthe379students,53%publishedtheirdissertationata medianof18-monthspost-enrolmentandmedianjournalimpactfactor219(range0-50) Paperspublishedhadameancitationof 3.90at2-years.At2-years,studentsaveraged2.1additional

publications(range0-30) HighergradesinRMSimprovedgradesinthe dissertationbutwerenotassociatedwithpublishingdissertation Students awardedwithdistinction/highdistinctionorthosewithpriorpublicationshad greatlyincreasedoddsofpublishingtheirdissertation(OR231,95%CI=145-367, p-value<0001;OR282,95%CI=182-438,p-value<0001respectively) Despite femalesupervisorsbeingassociatedwithhigherdissertationmark(IRR=296, 95%CI=050-543,p-value=0019),thosestudentswerelesslikelytopublishtheir dissertation(OR027,95%CI=012-061,p-value=0002)

Conclusion:Thehigh-qualitysurgicalresearchoutputfollowingtheMS dissertationissecondarytostructuredfacultyguidancewithinprojectsand structuredteachinginfoundationalresearchskills

THEUTILITYOFIVCDIAMETERFORTHEASSESSMENTOFHYPOVOLAEMICSHOCK INADULTTRAUMAPATIENTS

NandiniKarthikeyan(presenter,1,5),YenKim(1,2), ChristopherGroombridge(1,3,4),MarkFitzgerald(1,2,3)

1 NationalTraumaResearchInstitute,AlfredHealth, Melbourne,Victoria,Australia

2 DepartmentofSurgery,CentralClinicalSchool,Monash University,Melbourne,Victoria,Australia

3 TraumaService,AlfredHealth,Melbourne,Victoria,Australia

4 EmergencyandTraumaCentre,AlfredHealth,Melbourne,Victoria,Australia

5 SchoolofMedicine,MonashUniversity,Melbourne,Victoria,Australia

Background:Traumaticinjuryisaleadingcauseofdeathgloballyamongthose agedbetween10and29years Hypovolaemicshockrepresents25%of preventabledeathsfollowinginjury Currentsystemsusedtoclassify hypovolaemicshockarenotsuitableforahigh-intensitytraumaenvironment, orclinicallyaccurateforassessingthedegreeofshock Inferiorvenacava(IVC) diameterisademonstratedparameterofhypovolaemicshockinintensivecare settings However,itsfeasibilityasadiagnosticparameterhasnotbeen assessedinatraumareceptionsetting

Methods:Thiswasaprospectivecross-sectionalstudyofadulttraumapatients undergoingaFASTscan Asubxiphoidviewwasusedtocapturealong-axis imageoftheIVC IVCdiameterwasmeasured2cmcaudaltoitsconfluencewith thehepaticveins Theminimumdiameterduringinspirationandmaximum diameterduringexpirationwererecordedtocalculatethecollapsibilityindex Thetimetakentorecordthemeasurementswasalsorecorded

Results:Twenty-threeparticipantswererecruitedintotheshockedandnonshockedgroups ThemedianIVCdiametersduringinspirationandexpiration weresmallerintheshockedgroup(78mmand100mm)thaninthenonshockedgroup(137mmand172mm) IVCmeasurementsweresuccessfully obtainedinonly56%ofparticipants,demonstratingthattherewerebarriersto obtainingthesemeasurements Thesebarriersincludedoperatordependence fromvariationinclinicians’ultrasoundexperience,thepresenceofbowelgas andobesebodyhabitus

Conclusion:IVCmeasurementscouldnotbereliablyobtained,likelyprecluding thisassessmentfrombeingfeasibleinatraumareceptionenvironment

TRENDSANDPREDICTORSOFTOTALNEOADJUVANTTHERAPYINRECTAL CANCER:ABI-NATIONALREGISTRYSTUDYACROSSAUSTRALIAANDNEW ZEALAND

IshraqMurshed1,2(presenter),Sergei Bedrikovetski(1,2),ZacharyBunjo(1),HiddeM Kroon(1,2),MichelleThomas(1,2),Tarik Sammour(1,2)

1 DisciplineofSurgery,AdelaideMedicalSchool,FacultyofHealthandMedical Sciences,UniversityofAdelaide,Adelaide,SouthAustralia,Australia 2 ColorectalUnit,DepartmentofSurgery,RoyalAdelaideHospital,Adelaide, SouthAustralia,Australia,5000

Introduction:TotalNeoadjuvantTherapy(TNT),combiningneoadjuvant chemoradiotherapywithupfrontchemotherapy,hasimprovedoutcomesin locallyadvancedrectalcancer(LARC)andisincreasinglyincludedin internationalguidelines However,itsadoptioninAustraliaandNewZealand (ANZ)isnotwellunderstood

Methods:DatafromtheBowelCancerOutcomeRegistry(BCOR)forpatients diagnosedwithrectalcancerbetween2018and2024wereanalysed PatientswithLARCwhoreceivedneoadjuvanttherapy(NAT)wereclassified intostandardneoadjuvanttherapy(SNT)orTNT Theprimaryoutcomewas TNTutilisation,andmultivariatelogisticregressionidentifiedpredictive factors.

Session1

Results:Among4,657LARCpatients,706(218%)receivedTNT,and 2,528(782%)receivedSNT TNTuseincreasedfrom11%in2018to41%in 2023,particularlyinmid-lowandT3/4node-positiveLARC Factors associatedwithdecreasedTNTusewereolderage(OR0978,95%CI 0.970–0.985,p<0.001),absenceofmultidisciplinaryteam(MDT) discussion(OR0113,95%CI0027–0472,p=0003),andprivatehealth insurance(OR0619,95%CI0441–0869,p=0006) IncreasedTNTuse wasassociatedwithclinicalT4tumours(OR2020,95%CI1245–3280, p=0004),node-positivestatus(OR1481,95%CI1118–1964,p=0006) anddiagnosisbetween2019and2023(p<005forall)

Conclusion:TNTisincreasinglyusedinANZ,especiallyforT4and node-positivetumours Conversely,olderage,absenceofMDT discussion,andprivatehealthinsurancewerelinkedtolowerratesof TNTuse Thisstudyprovidesbaselinedataonrectalcancer managementinANZ,guidingfuturebenchmarkingefforts

TERTIARYCENTREEXPERIENCEOFHIGH-VOLUME,LOW-RISKPROSTATE CANCER:ACTIVESURVEILLANCEVERSUSRADICALTHERAPY

DarrenLam(presenter1),ShaotingZhang(1,2), KylieYen-YiLim(1),HarrisonLiu(1),JefferyJiang(1), EldoPaul(2),SteuartRorke(3),BeenaKumar(3), SeanLim(1),MatthewHarper(1),KevinChu(1), JamesHuang(1),NeiroshanRajarubendra(1),Paul Manohar(1),TrungPham(1),GideonBlecher(1), ScottDonnellan(1),WeranjaRanasinghe(1).

ology,MonashHealth,Melbourne,Australia ne,NursingandHealthscience,MonashUniversity, Melbourne,Australia

3 DepartmentofAnatomicalPathology,MonashHealth,Melbourne, Australia

Introduction:ActiveSurveillance(AS)isthestandardapproachforISUP gradegroup(GG1)prostatecancer(PCa) Weaimtoexaminethe oncologicaloutcomesofASversusradicaltreatmentforhigh-volume ISUP1PCa

Methods:Mendiagnosedwithhigh-volume(fiveormorepositive biopsycores)ISUPGG1PCaatatertiaryinstitutionreviewed retrospectively Allpatientswereengagedinashareddecision-making modelandcounselledonASandradicalprostatectomy(RP)atthe discretionofthereviewingclinician Coxregressionwasusedtoassess theassociationbetweenstudycohorts

Results:Outof84menwithhigh-volumeISUPGG1disease,56(667%)patients underwentAS,while17(202%)optedforRP Among16(286%)patientswho wereinitiallyplacedonASandlaterunderwentRP,twelvepatients(750%)had upgradedpathologytoclinicallysignificantPCaatre-biopsy,withamedian timeof74months Incontrast,amongsevenpatientswhounderwentupfrontRP, six(857%)showedupgradedpathologytoclinicallysignificantPCa,ofthose, five(833%)haddetectableMRIlesions(PI-RADS4/5) Therewasnostatistical differencewasobservedin≥pT3disease(0vs6intheASprogram,p=006),with onepatienthavingapositivesurgicalmargin

Conclusion:WhileourresultsdemonstratethatASinhigh-volumeISUPGG1is safe;over50%ofpatientsarelikelytohavediseaseupgradation Additionally, patientsundergoingASwithhighvolumeISUPGG1PCawithvisiblelesionson MRIscansshouldbecarefullymonitored,astheyexhibitedahigherlikelihoodof diseaseupstaging

PosterPresentations

Friday15November2024

Session2

KINEMATICANDKINETICDIFFERENCESINPAEDIATRICAND

AngelAulakh(presenter,1),KateDent(2),DrMartinaBarzan(1),DrSheannaMaine(1,2,3) 1 GriffithUniversity

Introduction:Recurrentpatellofemoraljoint(PFJ)dislocationcanresultinpain andreducedjointfunction Thisresearchaimstoanalysesubject-specificlimb anatomyandgaitcycletodeterminekeyvariablesinfluencingPFJdislocation asthereislimitedinsightintotheinterplayofpathoanatomyandgaitina dislocationevent,particularlyinthepaediatricandadolescentpopulation

Methods:MRIimagingandgaitanalysiswereobtainedfor24patientswitha historyofmultiplepatellardislocationsand25age-matchedcontrols Bony anatomywassegmented(Mimics250)andskeletalmodelsweregenerated (STAPLEMATLABtoolbox) Modelswerecombinedwithgaitcycle(OpenSim)to obtainkinematicdata Coronal,sagittalandaxialbiomechanicswereanalysed toidentifydifferencesbetweencontrolanddislocatorgroups

Results:Preliminarysegmentationandanalysisoftwocontrolsandtwo dislocatorshaveshownqualitativedifferencesinjointkinetics Comparedtothe controls,onedislocatorshowedreducedTFJflexionintheearlystagesofthe gaitcycleaswellasreducedhiprotationwhiletheseconddislocatorshowed reducedhipflexion Theresultsshowgreaterheterogeneitybetweenthe dislocatorsandgreatervariabilityingaittrials Theseresultswillcontinuetobe expandedandvalidated

Conclusion:Preliminaryanalysisshowsdifferencesinthegaitcycleof dislocatorscomparedtocontrols Innovatively,theuseofsubject-specific modellingallowsforindividualisedanalysisofpathoanatomyandprovides valuablestepstowardsinformingcliniciansonsubject-specificreparativeor correctivesurgicaldecisions

L JUNIORDOCTORS’PERSPECTIVEONCONVERSATIONS

NGRESUSCITATIONSTATUS,DEATHANDDYING TachelleTing(presenter,1),Dr.AndrewVanlint(2), Dr MatthewArnold(3)

1 FlindersUniversity,Adelaide,SouthAustralia

2 NALHN

3 UniversityofAdelaide thAustralianpublichealthsystem,juniordoctorsfrom p nwards(PGY2+)areexpectedtohaveroutineand event-drivenconversationswithpatientsandtheirfamiliesregarding resuscitationplans,deathanddying Anecdotally,manyjuniordoctorsfeel under-preparedtoundertaketheseconversationsinastructuredand informedmanner Thereisalsolittleformalisedtrainingfordoctorsin performingtheseduties Thisisaqualitative,interview-basedstudyseekingto elicitjuniordoctors’experienceswithsuchdiscussionsandperspectiveson currentandpotentialtrainingresourceswhichwouldbuildtheirskillsinthis importantandsensitivearea

Method:WerecruitedsevenPGY1-3doctorsandconductedsemi-structured1:1 virtualinterviewstobetterunderstandwhatformalorinformaltrainingis currentlybeingprovided,howtheyfeelaboutconductingresuscitationplan discussionswithpatients,andtoidentifywhatadditionaltrainingwouldbe helpful

Results:Juniordoctorsuniversallyhadminimalornoformaltrainingin conductingresuscitationplandiscussionsandreliedmostlyonobserving seniorswhentheywerestudentsorinterns Intervieweesfeltcomfortable conductingsimplediscussions,especiallywhenpatientsalreadyhad advancedcareplanswithevidencebasedlimitationsagreedon Interviewees founditchallengingtoconductdiscussionswherethepatientorfamily disagreedwiththedoctor’srecommendationsortherewassignificant complexityanddesiredmoretraininginordertobettermanagethese situations

Conclusion:Therearemanyexcellentresourcesfortraineestoacquireskillsin conductingdeathanddying-typediscussionsbutminimalonhowtoconduct advancedcareplanningandresuscitationplans

NEOADJUVANTCHEMOTHERAPYINLOCALLYADVANCEDCOLONCANCER:A

SYSTEMATICREVIEWANDMETA-ANALYSIS

RathinGosavi(presenter1,2)ClementeChia(1,2)Michael Michael(3)AlexanderG Heriot(1,4,5)SatishK Warrier(1,4, 5)JosephC Kong(1,4,5)

1.DivisionofMedicalOncology,PeterMacCallumCancer Centre,Melbourne,Victoria,Australia

2 DivisionofCancerResearch,PeterMacCallumCancerCentre,Melbourne, Victoria

3 ColorectalSurgeryDepartment,AlfredHealth,Melbourne,Victoria, 4 DivisionofCancerSurgery,PeterMacCallumCancerCentre,Melbourne, Victoria,Australia

5 SirPeterMacCallumDepartmentofOncology,UniversityofMelbourne, Parkville,Victoria,Australia

Background:Thereisincreasingevidencetosupporttheuseof neoadjuvantchemotherapy(NAC)inlocallyadvancedcoloncancer (LACC) However,itssafety,efficacyandsideeffectprofileisyettobe completelyelucidated

Methods:PubMed,EMBASEandMEDLINEweresearchedforasystematic reviewoftheliteraturefrom2000to2020 Eighteligiblestudieswere included,withatotalof1213patients,752(62%)ofwhomreceivedNAC Twowererandomisedcontrolledtrialscomparingneoadjuvant chemotherapyfollowedbyoncologicalresectiontoupfrontsurgery andadjuvantchemotherapy,threewereprospectivesingle-armphase IItrials,onewasaretrospectivestudyandtheremainingtwowere single-armretrospectivestudiesofneoadjuvantchemotherapy followedbysurgery

Results:AllcasesofLACCweredeterminedandstagedbycomputed tomography NACadministeredwaseitherfolinicacid,fluorouraciland oxaliplatin(FOLFOX)orcapecitabineandoxaliplatin(XELOX) Most studieshadNACcompletionratesofabove83% Timetosurgeryfrom completionofNACrangedonaveragefrom16to31days.The anastomoticleakrateintheNACgrouprangedfrom0to45%,withno casesofpostoperativemortality TheR0resectionrateintheNACgroup was961% Meta-analysisofbothRCTsincludedinthisstudyshowed thatneoadjuvantchemotherapyincreasedthelikelihoodofanegative resectionmarginT3/4advancedcoloncancer(pooledrelativeriskof 047witha95%confidenceinterval)withnoincreaseinadverse consequenceofanastomoticleak,woundinfectionorreturntotheatre

OUTCOMESOFASINGLECENTREREGIONALRENALPHYSICIAN-LED DIALYSISACCESSCLINIC:ACOMPARATIVESTUDY

NimaIranpour(presenter1),Saissan Rajendran(1)

1 ConcordRepatriationandGeneralHospital, Sydney,NewSouthWales

KaviyaKalyanasundaram(presenter,1,2),Sarah Vreugde(1,2),AlkisPsaltis(1,2,3),Peter-JohnWormald (1,2,3)

1AdelaideMedicalSchool,TheUniversityofAdelaide,Adelaide,SA,Australia

2DepartmentofSurgery-OtolaryngologyHeadandNeckSurgery,BasilHetzel InstituteforTranslationalHealthResearch,CentralAdelaideLocalHealth Network,WoodvilleSouth,SA,Australia

3DepartmentofOtolaryngology,HeadandNeckSurgery,QueenElizabeth Hospital

Introduction:Chronicrhinosinusitis(CRS),affecting98%oftheAustralian population,isthoughttobeduetothecolonisationwithpathogenicbacteria, mostcommonlyStaphylococcusaureus

TheincreasingprevalenceofantibioticresistanceinSaureusiscausing problemswitheffectivetreatment,leadingtoprolongedmorbidityinpatients UseofbacteriophageasatreatmentforCRShasshowngreatpromise,butit cannotbeusedagainstphageresistantbacteriawhicharebeingincreasingly discovered Previousfindingsfromourresearchhasshownthatphages generatedinthepresenceoflowantibioticconcentrationscankillphageresistantSaureus

Aim:Totestthesafetyandefficacyofexitphageinvivoinkillingphage resistantS aureus

Methods:Thesafetyandefficacyofthegeneratedphageweretestedinarat modelofsinusitisinfectedwiththephage-resistantS aureus

Results:Lowphagetitresandnormalhistologyofsinusesandorgansafter applicationofhighdosephageintranasallyfor21daysdemonstratedsafety Efficacytrialsinvolved(n=72)ratsinfectedwithphage-resistantSaureus randomisedtoreceive2concentrationsofphageorsalineintranasallyforupto 7days Asignificantdifferenceinthebacterialcountswasseenatdays3,5and 7(p<005) Histologicalinflammationgradeandconfocalmicroscopyshowing liveanddeadbacteriasupplementthesefindings

Conclusion:Preliminaryresultsarepromising:exitphagetherapyhasthe potentialtotransformlivesofCRSpatientsinfectedwithphageandantibiotic resistantSaureus Thistherapycanbeextendedtootherinfectionscausedby Saureusandpotentiallyotherbacterialinfections

Introduction:Metropolitanrenalaccessclinics(RAC)havebeen vascular-ledduetotheintricaciesofsurveillanceandspecialistopen andendovascularintervention Intheruralsettingsthismaynotbe feasible ThisstudyinvestigatestheoutcomesofDubboBaseHospital, aruralrenalphysician-ledRACwithfly-invascularservices The effectivenessofthemodelismeasuredbycomparingoutcomes betweenregionalandmetropolitancentresinNSW

Method:DatawasextractedfromtheANZDialysisandTransplant Registry,from2020-2023 DubbowascomparedtootherNSW Hospitalscodedaseitherruralormetropolitan Statisticalanalysis wasconductedusingPearson’schi-squaretesttoassessthe significanceofdifferences(p<0005)inpatientoutcomes

Results:Analysisshowedaphysician-ledRACwithfly-invascular surgeryserviceswasnotinferiortometropolitanRACs Interestingly, Dubboachievedsignificantlyhigherratesofpermanentvascular accessatfirsthaemodialysiscomparedtocombinedruralandurban centresinNSW Dubboreportedincreasedpermanentaccessatthe startoffirstdialysisfrom40%-75%between2020and2023(chisquare20851(p=0002)) Incontrast,ruralcentresaveraged46% andurbancentres41%forpermanentaccess

Withdrawn

Conclusion:Thefindingssuggestthatarenalphysician-ledRACsin theregionalsettingisafeasiblemodeltobridgethegapforaccessto surgicalspecialistservicesavailableinMetropolitanareas Further researchisneededtoconfirmtheseresultsacrossarangeofrenal physician-ledclinicsandtoaccountforpotentialconfoundingfactors andshouldconsiderretrospectivecohortanalysestoexplorethe long-termbenefitsofthisapproach

Session3

POST-OPERATIVEFUNCTIONALASSESSMENTINANAEMIC PATIENTS–AFEASIBILITYSTUDY

JaahnaviSaiCheyyur(presenter,1),Riki Wylie(presenter,1),SijingZhang(1),Beth MacLean(1),TobyRichards(1,2)

1 SchoolofMedicine,TheUniversityof WesternAustralia,Perth,WesternAustralia, Australia

2 DepartmentofSurgery,UniversityCollege London,London,UnitedKingdom

Introduction:Anaemiaiscommoninsurgicalpatientsandis associatedwithpoorpost-operativeoutcomes IVironisanattractive treatment,butitseffectsonfunctionaloutcomesareunclear We designedanRCTtoanswerthisquestion Ourstudyaimedtoassess thefeasibilityofrecruitinganaemicpatientstoa12-weekexercisetrial

Methods: Weidentifiedpatientswhounderwentmajorabdominal surgeryatatertiaryhospitalinPerth,WA Patienteligibilitycriteria includedage≥18years,andhaemoglobin(Hb)levelsindicativeof anaemia(<120g/Lforfemalesand<130g/Lformales Primary outcomeswererecruitmentrateandlosstofollow-up Secondary outcomesincludedincidenceofanaemiaandreasonsfornonparticipation

Results:Outof171patientswhohadmajorabdominalsurgery,138were eligible,butourrecruitmentratewasonly29%over6months Outof fourrandomisedpatients,oneparticipantcompletedthe12-week exerciseprogramwiththeotherslosttofollow-uppriortothefirst assessmentpostrandomisation Themainreasonscitedfordeclining participationweredisinterest/unwillingnesstoparticipateinthetrial, followedbytravelandconcernoversurgical/medicalfactors Overall, theprevalenceofanaemiawas807% Ofthoseeligible,mean haemoglobinlevelwas1045g/L[SD±143g/L] Anaemiawasmost evidentinthosewhounderwentuppergastrointestinalsurgery (Hb=979g/L)

Conclusion:Duetothelowrecruitmentrateobserved,itisnotfeasible toassesspost-operativefunctionaloutcomesinanaemicpatients Revisingtrialprotocolstoaddresslogisticalissuesmayleadto increasedrecruitment

ASURVEYOFSURGEONSPERCEPTIONSOFDEFININGANDRECORDING COMPLICATIONSASSOCIATEDWITHELECTIVE,EMERGENCYANDNONOPERATIVESURGICALADMISSIONS.

MartySmith(presenter,1),PaulBurton(1,2),Kalai Shaw(1),AnagiWickramesinghe(2)

1 DepartmentofGeneralSurgery,AlfredHealth, Melbourne,Victoria

2 MonashUniversityDepartmentofSurgery, Melbourne,Victoria

TheClavien-Dindodefinitionofasurgicalcomplication:“anydeviation fromthenormalpostoperativecourse”remainsthemostaccepted definition

Despitethewidespreaduse,theinterpretationandlimitsofthis definitionhavenotbeensurveyed Itsuseinemergencygeneral surgerycontextisalsolimitedbythestatedexclusionofanyevent occurringinthepre-operativephaseofcareorinnon-operative patients

Weaimedtotestthelimitsofthecomplicationdefinitionbyasurvey ofsurgeon’sperceptionsandinterpretationsofclinicalvignettes A surveyof43casevignettesoccurringinallphasesofelective, emergencyoperativeandnon-operativecarewasdevelopedand distributedto77practisingsurgeonsacrossfourtertiaryhospitalsin Melbourne Thecollatedresultswereanalysedforinterrater agreementusingFleissKappastatistic

Fifty-fivesurgeons(71%)responded Thebinarizedproportionalacceptanceof aneventasacomplicationrangedfrom94%(post-operativefever)to100% (unplannedsplenectomy) Therewasbroadsupportforthepresentedpreoperative,intra-operative,andnon-operativeeventsbeingclassedassurgical complications Post-operativeeventswereacceptedascomplicationaccording totheperceivedseverityoftheevent Interrateragreementacrossallscenarios wasfair(Kappa=0254,P<0005);agreementacrossSurgeonsubgroupswas poortofair(Kappa=0194-0458)

Ouranalysisdemonstratesthatdespitean“accepted”definitionthereremains substantialdifferencesininterpretationastowhatshouldbereferredtoasa surgicalcomplication Thishasimplicationsforcurrentandfutureresearchin thatreportingofoveralladmissionmorbiditymaybevariableaccordingtolocal interpretationsofthecomplicationdefinition

COMPARISONOFPRE,MIDANDPOST-PANDEMICEMERGENCYCOLORECTAL CANCERPRESENTATIONSATTHESUNSHINECOASTUNIVERSITYHOSPITAL

MarcioBrussiusCoelho(presenter,1),RoisinChu(2),Zachary Woodward(1),BreeStephensen(1)

1 SunshineCoastUniversityHospital,SunshineCoast, Queensland

2.SchoolofMedicine,GriffithUniversity,Queensland

Introduction:TheCOVID-19pandemichasdisruptedtheoptimaldeliveryof publichealthcareandaffectedthedetectionandmanagementofcolorectal cancer(CRC) InAustralia,thepublichealthmeasuresandsocialimpactofthe pandemichaveallnegativelyaffectedthemanagementofCRC,resultinginyet unknownlong-termeffects ThisstudyaimstocompareemergencyCRC presentationstoourunitandassesstheimpactofCOVID-19onthese presentation’soutcomes

Methods: Retrospectivecohortstudyperformedatatertiaryreferralcentre acutesurgeryunitwithacatchmentareaofalmost500000people,comparing patientswhopresentedtoemergencywithcomplicationsfromCRCbetween1st February2019–29thFebruary2020(pre-COVID),1st March2020–30thJune 2022(mid-COVID)and1stJuly2022–30thJune2023(post-COVID)

Results:183patientspresentedtoourunitasasurgicalemergencysecondary toCRC Ofthose,38wereinthepre-pandemicgroup,91presentedduringthe pandemicand54wereinthepost-pandemicgroup Duringthefollowupperiod of6years,morethan50%ofpatientsdied Moreadvancedstageswere observedduringandafterthepandemic Theaverageagewas67yearsofage (range:17-91)

Conclusion:Weobservedanincreaseinthenumberofemergencycolorectal cancerpresentationssincepriortotheCOVID-19pandemic,withpatients presentingwithmoreadvancedstages Thisraisesthepossibilitythatthe pandemichasaffectedsurveillancemethodsanddelayedpatient’s presentationstodoctorsduetofearofexposuretotheCOVID-19

AUDITOFAUDIOLOGY-LEDFOLLOW-UPFORGROMMETINSERTION

SophieDunmall(1),EngHooiOoi(1)

1

OtolaryngologyHeadandNeckSurgery,Flinders MedicalCentre,SouthernAdelaideLocal HealthcareNetworkandCollegeofMedicineand PublicHealth,FlindersUniversity,BedfordParkSA 5042

Introduction:Grommetinsertionisoftenperformedforrecurrentotitis mediaorhearinglossduetomiddleeareffusions Patientsare reviewedpost-operativelytoensurehearinghasreturnedtonormal andidentifycomplications Itisunclearifthisprocesscanbedoneby anaudiologistinsteadofENTsurgeon Wedesignedaprotocolfor audiology-ledreviewanddischargeofpatientsorreviewbyENTif patientsmetspecificaudiologicalcriteria

Methods:Thisisaretrospectiveauditoftheaudiology-ledreview protocolofpaediatricpatientsfollowinggrommetinsertionataSouth Australiantertiaryhospitalin2021 Theprimaryoutcomewasthe numberofpatientsdischargedbyaudiology Thesecondaryoutcomes wereaudiometryresults,waitingtimesforanENTappointment followingre-referralbyaudiologyandcomparativecostsofthis protocol

Results:50consecutivepaediatricpatients(9monthsto12yearsold) wereidentifiedintheaudit Themedianlengthoffollow-upwas17 months 25(50%)patientsweredischargedwithnormalaudiometry Therewere128audiologyand66ENT(ofwhich23wereroutine6-week post-operative)clinicappointmentsfollowinggrommetinsertion,with anestimatedcostsavingof$8448fortheaudiology-ledprotocol 19 patientswerere-referredtoENTclinicforabnormalaudiometryor recurrentinfection 9(18%)patientsunderwentgrommetre-insertion ThemedianwaittimeforanENTappointmentfromaudiologyreferral was24months

Conclusion:Anaudiology-ledmodelofcareofpatientspostgrommet insertionissafe,cost-effectiveandfeasibleforpatientstoaccessENT clinicsinatimelymannerifrequired SurgicalResearchSocietyofAustralasiaFundAwardconditionscanbe foundontheRACSWebsitehereoremail

AcademicSurgery@surgeonsorgfordetails **Someawardsare subjecttofundingconfirmationanddetailswillbereleasedinthe program

ECONOMICEVALUATIONOF‘WATCHANDWAIT’FOLLOWING NEOADJUVANTTHERAPYINLOCALLYADVANCEDRECTALCANCER:A SYSTEMATICREVIEW

IshraqMurshed(presenter,1,2),ZacharyBunjo(1), WarrenSeow(1),IshmamMurshed(1),Sergei Bedrikovetski(2),MichelleThomas(1,2),Tarik Sammour(1,2)

1.DisciplineofSurgery,AdelaideMedicalSchool, FacultyofHealthandMedicalSciences,Universityof Adelaide,Adelaide,SouthAustralia,Australia

2 ColorectalUnit,DepartmentofSurgery,Royal AdelaideHospital,Adelaide,SouthAustralia,5000, Australia

Introduction:Owingtomulti-modaltreatmentandcomplexsurgery, locallyadvancedrectalcancer(LARC)exertsalargehealthcare burden Watchandwait(W&W)maybecostsavingbyremovingthe needforsurgeryandinpatientcare Thissystematicreviewseeksto identifytheeconomicimpactofW&Wcomparedtostandardcare,in patientsachievingacompleteclinicalresponse(cCR)following neoadjuvanttherapyforLARC

Methods:PubMed,OVIDMedline,OVIDEmbaseandCochraneCENTRAL databasesweresystematicallysearchedfrominceptionto26April 2024 Alleconomicevaluations(EEs)thatcomparedW&Wtostandard carewereincluded Reportingandmethodologicalqualitywas assessedwiththeCHEERS,BMJandPhilipschecklist Narrativesynthesis wasperformed Primaryandsecondaryoutcomeswere(Incremental) Cost-EffectivenessRatiosandtheNetFinancialCost

Results:Of1548studiesidentified,27wereassessedforfulltext eligibilityand12studiesfrom8countries(2016-2024)wereincluded. SevenCost-EffectivenessAnalyses(completeEEs)andfiveCost Analyses(partialEEs)utilisedmodel-based(n=7)ortrial-based(n=5) analyticswithsignificantvariationsinmethodologicaldesignand reportingquality W&Wshowedconsistentcost-effectiveness(n=7) andcost-saving(n=12)comparedtosurgeryfromthird-partypayer andpatientperspectives Criticalparametersidentifiedbyuncertainty analysiswereratesoflocalanddistantrecurrenceinW&W,salvage surgery,perioperativemortalityandutilitiesassignedtoW&Wand surgery

Conclusion:Despiteheterogenousmethodologicaldesignand reportingquality,W&Wislikelytobecost-effectiveandcost-saving comparedtostandardcarefollowingcCRinLARC Registration:PROSPEROCRD42024513874

EARLYCOLLABORATIVE STUDYIDEASWORKSHOP

Panel

EarlyCollaborativeStudyIdeasWorkshop

16thNovemberfrom8:00am-9:00am

TheEarlyCollaborativeStudyIdeasWorkshopisan hoursessionheldondaytwoofNAASC

Thisisanopportunityforearlysurgicalresearch ideas/studiestobepresentedinfrontofapanelof experiencedAcademicSurgeons

ThisyearspanelisProfessorDavidBeard,Professor DavidWatson,DoctorHelenMohanandProfessorGuy Maddern

Theaimofthesessionistoofferexpertadvice todevelopyourresearchstudydesign Eachabstract selectedwillgiveashortpresentationofthestudy conceptfollowedbyinformaldiscussionwiththepanel.

Twopresentationswillbeselectedfollowingthe workshoptopresentintheconferenceprogramwith thehighestscoringpresentationbeingawardedthe EmbryonicStudyPrize.

Presenter:DrGabrielOsie

LeadInvestigator:DrGabrielOsie

AppliedMedicalResearchCentreUNSW

DiseaseArea

Nasalobstruction

StudyAim

Tometaanalysecurrentresearchontheimpactofnasalobstructiononcardiopulmonaryfunction

ConceptandResearchQuestion

Concept:Ametaanalysisoncurrentresearchthatlooksattheimpactofnasalobstructiononcardiopulmonaryfunction.

ResearchQuestion:Howdoesnasalobstructionaffectone’slungfunctionandexerciseperformance Therearemany differentstudiesthatlookatthisquestionin1formoranother Studiesthatcomparepatientspreandpostsinonasalsurgery patients,studiesthatcomparepatientswithnasalobstructiontocontrols,studiesthatlookat‘normalpatients’and comparetheirexerciseperformanceoutcomeswhenbreathingthroughthemouthornose,studiesthatlookat mechanicallysplintingthenoseopenandassessingtherespiratoryimpactthathas

BackgroundandJustification

Peopleoftenunderestimatetheimportanceofnasalbreathing.Nasalobstructionisanuncomfortablesensation.Oneneeds onlytohaveacommoncoldtoexperiencethis

Thenoseisessentialforfiltering,humidifying,andwarminginhaledair.Whenthenoseisobstructed,peopleresorttomouth breathingwhichcannotperformthesefunctions.

Existingstudieshavevariablefindingsontherelationshipbetweennasalobstructionandpulmonaryfunctionandexercise performance

Thissystematicreviewandmeta-analysisaimstoconsolidatecurrentevidence,providingamorecomprehensive understandingofhownasalobstructionimpactspulmonaryfunctionandexerciseperformance,whichmayguidefuture researchandclinicalinterventions

Studydesign

Abroadyetthoroughdatabasesearchwillbeperformedtocaptureallarticlesthatcouldpossiblyexplorethisquestion

Population:Adultsandchildren>5yearsold.

Intervention/exposure:patientswithnasalobstruction.Thismayincludepatientswithpathologicalnasalobstruction (whetherthat’ssubjectiveorobjective)orexperimentalobstruction(eg vianasalclips)

Control/comparison:patientswhoarenormalnasalbreathers Thismayincludeeitheranormalcontrolpopulation,post operativepatients,orpatientswithoutexperimentalobstruction.

Outcomes:–objectiverespiratoryandexerciseperformanceoutcomes.

-Respiratory

oSpirometry(eg FEV1,FVC,FEV1/FVC),pulseoximetry,FEF25-75,PEFR,tidalvolumesetc

-Exerciseperformance

oVO2max,HRmax,poweroutput,maxspeed,maxexercisetimeetc.

Ameta-analysisoftheresultswillbeperformedifadequatedataiscollected

PrimaryAim

TodeterminetheproportionofallliverresectionsthatareperformedforpatientswithNCLMinAustraliaoverthelastten years(2014-2023),withcomparisoninratesbetweenthefirstandlastfive-yearperiod

Presenter:DrSiobhanMcKay

LeadInvestigator:ProfessorAnubhavMittal

UGIDepartment,RoyalNorthShoreHospital,Sydney DiseaseArea

Pre-operativeimagingforpredictingpost-pancreatoduodenectomypancreaticfistula(CR-POPF)risk

StudyAim

Evaluatetheutilityofpre-operativepancreatic-tail-densityonCTforpredictingCR-POPF.

ConceptandResearchQuestion

Thisinternational,multicentre,retrospectivestudyaimstoassesstheclinicalutilityofpre-operativeCTimagingofthe pancreatictailtopredicttheriskofCR-POPF.Byanalysingpancreatictaildensityandenhancement correlatesforacinar celldensity thestudyseekstoestablishareliable,non-invasiveriskpredictiontoolthatsupportssurgicaldecision-making andoptimisespatientoutcomesinapragmaticreal-worldsetting

BackgroundandJustification

Post-operativepancreaticfistulaisamajorcauseofmorbidityandmortalityfollowingpancreatoduodenectomy Although advancesinsurgicaltechniqueshaveloweredmorbidityratesinhigh-volumecentrestounder1%,theincreasinginclusion ofelderlyandcomorbidpatientshasledtohigherratespost-operativemorbidity,particularlyincaseswithoutpancreatic ductobstruction.

Theacinarcellscore,measuringacinarcellandadipocytedensity,hasshownpromiseasanintra-operativepredictorof CR-POPFrisk Pancreatictaildensityandenhancementonpre-operativeCThavebeencorrelatedwithacinarcellscores, suggestingpotentialasapre-operativetoolforpredictingCR-POPF.AriskpredictionmodelbasedonCTwouldenhance individualiseddecision-makingandinformsurgicaldiscussions.

Ourpilotstudy(n=90)demonstratednon-contrastdensityofthepancreatictaileffectivelypredictedPOPF(AUROC0704, p=0.036),cutoffof>40Hounsfieldunitsyielding70%sensitivityand73.4%specificity.Thisstraightforwardmeasurecould integrateintosynopticimagingreports,supportingsurgical planning/consent

Studydesign

Population:Consecutivepatientsundergoingpancreatoduodenectomyforanyindicationfrom2022-2024.

Intervention:Pre-operativeCTassessmentofpancreatictaildensityandenhancement

Comparator:Existingpre-operativeriskpredictiontools

Outcome:Incidenceofclinicallyrelevantpost-operativepancreaticfistula(CR-POPF).

PrimaryObjective

Todeterminetherelationshipbetweenpre-operativepancreatictaildensity/enhancementonCTandCR-POPFincidence

StudyDesign

Thisretrospective,multicentrecohortstudywillestablishapragmatic,non-invasivepredictionmodelforCR-POPFbasedon existingpre-operativeCTimaging AnonymiseddatawillbeenteredintoacentralREDCapdatabaseforanalysis Allcentres performingpancreatoduodenectomyinternationallywillbeinvitedtojointhestudy. Thestudywillutiliseandstrengthen existingHPBcollaborativenetworkstoensurewidespreadstudyrecruitment.

Presenter:MrJathinSilochan

LeadInvestigator:MrJathinSilochan

NationalInstituteofStrokeandAppliedNeurosciences

DiseaseArea

Post-operativecare,cognitiveimpairment,indigenoushealth

StudyAim

Improvethepost-operativeoutcomeofindividualswhohavebeenaffectedbycognitiveimpairment

ConceptandResearchQuestion

Individualsover65thathavebeendiagnosedwithmildtomoderatecognitiveimpairmentasaresultofneurodegenerative diseases(NDD),suchasdementiaandorAlzheimer's,areupto83%morelikelytosufferafall-mostresultinginahip fractureandrequiringsurgicalinterventionwithinayear.However,thescarceresearchonpatientswhohaveundergone surgicaltreatmentswithpre-existingNDDsuggestthattheynotonlyhavepooreroutcomespostoperatively;butarealso lesslikelytobeadmittedintolongtermcarefacilities(LTC)suggestingthattheymaynotbereceivingthesameaccessto careasnonNDDpatients Inpart,thiscouldbeduetotheinabilityofNDDpatientstocommunicatetheextentoftheirissues (anosognosia)butalsothereluctancyofNDDpatientstobeplacedinaforeignenvironment.Ibelievemorecanbedonefor NDDpatientsthatwon'trequireLTC

BackgroundandJustification

AotearoahasanageingpopulationwithanincreasingprevalenceofNDD-thefiguressuggestthatthiswillmeanalikelyrise indemandforfallsrelatedsurgicalintervention

Inordertobetterservethiscommunityofadultsweneedtounderstandtheirneedsandhowtoworkwiththem

Acommonthemeatmanyagedcarefacilitiesisthattheysimplydonothavethespacetocatertothegrowingdemand Additionally,inmanyMāoriandPasifiskafamilies,eldersremainathomeforotherfamilymemberstotakecareof Inorder toeasethelikelydemandinsurgicalinterventionandimprovehealthoutcomespostoperativelyforthewiderangeof patientsseeninAotearoa,weneedtoexploreavenuesofimprovingaccessandeducationtonotjustagedcarefacilities butalsofamilycaregivers Thiswillhavebenefitsonmanyaspectsofpostoperativecare

Studydesign

TheprimaryobjectiveofthestudyistofindmechanismsofimprovingpostoperativecareofNDDpatients-specificallythose whohavesufferedafallandrequiresurgery

Thepatients,orpopulation,willbeanyonewhohasbeendiagnosedwithmildtomoderatedementiaANDhashadafall requiringlowerlimbicsurgicalintervention.Wewillberecruitingfromavarietyofethnicities,incomes,gendersand backgrounds.Thislargepopulationwillgiveustheabilitytoidentifyvulnerablegroupsaswellasalargepopulationsizehas manybenefitstothevalidityofthestudy

Theinterventionofthestudywillbefocusingoneducationandortheuseoftechnology(suchasmobileapps)toensure thatthepatientsareimprovingpostoperatively.Thiscanbesomethingsimplelikeensuringthatthestayhomecaregivers areawareofthebenefitsofencouragingphysicalrehabilitation,ortheintroductionanduseofamobileappthatreminds, andencourages,thepatientontheirpostoperativejourney

Currently,therehavenotbeenspecificstudiesthathavetriedtoimprovethepostoperativecareofNDDpatients.Similar studieshavehighlightedthatNDD/dementiapatientshavepoorerhealthoutcomesbuttherehasyettobeanactivestudy thatlooksatwaystoimprovetheirpostoperativecare

Theoutcomesofthestudywillbemeasuredinthelongtermbenefits.Asmentioned,poorerhealthoutcomesofNDD patientsmeansthattheyarelikelytohaveanotherfallandorfurthercomplicationspostsurgery Iftheinterventionis successfulandtheyareabletorehabilitatepostoperativelywewillseealowernumberofreturnvisitsfromNDDpatients requiringfurthersurgeryorotherrelatedmedicaltreatment.

Presenter:SarahLin

LeadInvestigator:TBA

TrialsandAuditsinSurgerybyMedicalStudentsinAustraliaandNewZealand(TASMAN)

DiseaseArea

Preoperativeanxiety

StudyAim

Toinvestigatetheimpactofpreoperativeanxietyonpostoperativepainoutcomes

ConceptandResearchQuestion

Whatistheimpactofpreoperativeanxietyonpostoperativeanalgesiaconsumptionandpatientreportedpainoutcomes? Thisstudywillaimtoprovideanunderstandingofhowpreoperativeanxietyinfluencespostoperativepain,contributing valuableinsightstoperioperativecare Thefindingsmayhelpinformstrategiestoimprovepainmanagementandsurgical recoverybasedonresultsofpreoperativepsychologicalassessments

BackgroundandJustification

Preoperativeanxietyisdefinedasthefeelingofuneaseorfearthatresultsfromconcernsrelatingtoapatient'ssurgeryor anaesthesia Preoperativeanxietytriggersarangeofpsychologicalandphysiologicalresponses,withclinical manifestationsincludingirritability,tachycardiaandhypertensionthatarelargelydrivenbyheightenedautonomicactivity. Increasedpreoperativeanxietyhasbeenassociatedwithhigherincidencesofpostoperativeadverseevents,lowerlevelsof patientsatisfaction,andhigheranalgesicrequirementsfollowingsurgery

However,mostexistingresearchontheeffectsofpreoperativeanxietyonpostoperativepainoutcomesarelimitedto dental,gynaecologicalorveryselectivegeneralsurgeryprocedures Thereisanotablegapintheliteratureconcerningthe broaderelectivesurgerypopulation,particularlyinrelationtopostoperativeanalgesicuse Furthermore,nostudiestoour knowledgehavespecificallyexaminedtheseeffectsinAustralianandNewZealandelectivesurgerycohorts

Studydesign

P:Adultsaged18andoverundergoingelectivesurgeryrequiringgeneralanaesthesia

I/E:Highpreoperativeanxietylevel

C:Adultswithnotolittlepreoperativeanxiety

O:Postoperativeanalgesiaconsumption(measuredinoralmorphineequivalentdoses)

QUESTisaninternational,multicentre,cross-sectionalobservationalstudywiththeprimaryobjectiveofquantifyingthe impactofpreoperativeanxietyonpostoperativeanalgesicconsumption Itwillrunasacollaborativeresearchtrial modelwithdatacollectionperiodsoccurringoverthreecontinuoustwo-weekstudyperiods.

Patientsundergoingelectivesurgicalprocedureswillbeidentifiedandinvitedtoparticipate Afterconsentisgained, preoperativeanxietylevelswillbeassessedusingtheSurgicalAnxietyQuestionnaire Thisisavalidated17-itemselfreportedquestionnairethatpatientscancompleteasanonlinesurvey,withquestionsinvestigatinganxiety-inducing concernsregardingtheirgeneralhealth,surgicalrecoveryandthesurgicalprocedureitself Patientswillbefollowedupfor sevendaysaftersurgery Duringthistime,in-hospitalopioidconsumptionwillbedocumented Atsevendayspostsurgery, patientswillbeaskedtocompleteanotheronlinesurveytoquantifyopioidconsumptionafterdischarge(ifany),andto evaluatepatientreportedpainoutcomesusingtheAmericanPainSocietyPatientOutcomeQuestionnaire(APS-POQ-R).

Theprimaryobjectiveistodefineanyassociationbetweenpreoperativeanxietyandpostoperativepainasmeasuredby ourprimaryoutcomeofpostoperativeopioidconsumptionandsecondarypatientreportedpainoutcomesobtainedfrom theAPS-POQ-R.TherelationshipbetweenpreoperativeanxietyandopioidusewillbeassessedusingPearson’scorrelation coefficient Subgroupanalyseswillexplorevariationsinoutcomesacrossdemographicfactorsandsurgicaltypes

Presenter:DrChristineLi

LeadInvestigator:DrBenjaminLoveday

PeterMacCallumCancerCentre DiseaseArea Liverresections

StudyAim

Determine&characterisetheproportionofliverresectionsforNCLMinAustraliaoverthelast10yr

ConceptandResearchQuestion

ThisisanAustralia-wide,multi-institutionalretrospectivecohortstudyofpatientswhohaveundergonealiverresectionfor primarylivercancer,metastasestotheliver,orbenigndiseaseoverthelasttenyears(2014-2023) Asuiteofsub-studieswill beundertakentoanalyseindividualcohortsseparately

ThefirstAUSLIVERstudywillanalysepatientswhohaveundergonealiverresectionfornon-colorectallivermetastases (NCLM),takingdatafromwithintheentireAUSLIVERcohort

Weaimtocharacterisethiscohortofpatientsand,inparticular,toidentifyhowthishaschangedoverthetenyearstudy period Weaimtoprovideanationalanalysisofpatternsofcareovertimeandtoidentifywhethertheimplementationof newtechnologies,suchasroboticsurgery,andtheadventofimmunotherapyisassociatedwithchangesinthepatternof liverresectionsforNCLM

BackgroundandJustification

HepatectomyforNCLMisperformedinfrequentlyduetouncertaintyaboutitsoncologicbenefitformanycancers However, thereisincreasinginterestintheroleofliverresectionforthesepatientstoimprovedisease-freeandoverallsurvival Cancertreatmentshaveevolvedovertimewithdevelopmentofmoreeffectivechemotherapyregimens,immunotherapy, targetedtherapies,andtheranosticapproaches Inparticular,immunotherapyhastransformedthemanagementofmany malignancies,suchthatliverresectionisnowconsideredtoremoveresidualoroligoprogressivedisease

DataaboutsurgicalmanagementofNCLMpredominantlycomesfromsmall,singleinstitutionobservationalstudies There isonepreviousAustralianstudyonthesurgicalmanagementofNCLM,publishedin2016,with16patientsfromasingleunit DatafromothercountriesmaynotbegeneralisabletotheAustraliancontext

ThisstudywillprovideanAustraliananalysisofliverresectionforNCLMandwillbetheonlystudyofitstypeinthisregion Studydesign

ThisisanAustralia-wide,multi-institutionalretrospectivecohortstudywithcentres(publicandprivatehospitals)invitedto participate TheentireAUSLIVERcohortwillincludeallconsecutiveunselectedpatientswhohaveundergoneliverresection between1January2014and31December2023 ThefirstAUSLIVERstudywillanalysespecificallypatientswhohave undergonealiverresectionforNCLMwithinthiscohort,asconfirmedhistopathologically Datapointswillbecollectedby individualsites,andthencollatedandanalysedbytheprimarysite.

Population:liverresectionfornon-colorectallivermetastasisinAustraliabetween2014-2023

Intervention:evolvingcancertherapiesovertime

Comparison:comparingthefirstfive-yearperiod(2014-2018)andsecondfive-yearperiod(2019-2023).

Outcome:proportionofliverresectionsforNCLM,changeincohortofpatientswhoundergoliverresectionforNCLM, differencesinperi-operativeanti-cancertherapies

PrimaryAim

TodeterminetheproportionofallliverresectionsthatareperformedforpatientswithNCLMinAustraliaoverthelastten years(2014-2023),withcomparisoninratesbetweenthefirstandlastfive-yearperiod

SecondaryAims

TocharacterisethecohortofpatientsinAustraliawhounderwentliverresectionforNCLMoverthelasttenyears

TodeterminetheresectiontechniquesforNCLM(majorversusminorliverresection)

Todetermineanydifferencesinprimarydiagnosesoverthestudyperiod

Todetermineanydifferencesinperi-operativechemotherapyandimmunotherapyregimesbetweencohortsfromthe firstandsecondfiveyearsofthestudyperiod

TodetermineoverallsurvivalforpatientswhoundergoliverresectionforNCLM

Presenter:DrChenLew

LeadInvestigator:DrJuneOo

GeneralSurgery/AlfredHealth

DiseaseArea

Trauma,Bluntliverinjury,Hepaticembolisation,ERCP,Infectivecomplications

StudyAim

Toassesstheoutcomeofmajorliverinjuriesinlevel1traumacentersinAustralia

ConceptandResearchQuestion

Thismulticentrestudywillinvestigatetheoveralloutcomesfollowingmajorbluntlivertrauma,inparticularmanagementof liverspecificcomplicationsfollowinginjury Datafromlevel-1traumacentreswillbeanalysedtoprovideacomprehensive understandingoftheapproachestomanagingcomplexliverinjuriesanditsassociatedcomplications.Theultimategoalis todevelopacollaborativetraineenetworkforlivertraumaresearchacrossAustralia,withtheaimtoupdateclinical guidelinesonmanagementofbluntlivertrauma,inparticularmanagementofcomplicationspostinjury

BackgroundandJustification

Bluntliverinjury,acommonfindinginabdominaltrauma,oftenleadstocomplicationssuchasbileleak Hepatic embolisationforcontrollinghaemorrhageinhigh-gradeliverinjuriesalsoincreasesbileleakrisk Asingle-centrestudy foundbileleakin49%ofbluntlivertraumacases,withagreaterincidenceinthoseundergoinghepaticembolisation ERCP iswidelyusedtomanagetheseleaks,althoughearlyERCPmayincreaseinfectionrisk.Surgicalandpercutaneous interventionsarealsoessentialmanagementoptions,especiallyincomplexcases Amulticentrestudywillprovidebroader dataontimingandoutcomesoftheseinterventionstorefinebestpractices

Thismulti-specialtycollaborationwillinvitealllevel-1traumacentrestocontribute. Althoughbluntliverinjuryiscommon, biliarycomplicationsarelessfrequent Amulticentredesignwillincreasethenumberofcasesassessedforthiscomplex clinicalquestion Thismulti-specialtystudywillfostercollaborationacrosstheAustraliantraumanetworkpromotingfuture studies

Studydesign

Population:Adultpatients(18years+)withbluntlivertraumaatAustralianlevel-1traumacentresIntervention:Active managementapproachesforliver-specificcomplications,includinghepaticembolisation,ERCP,percutaneous drainage,andsurgicalinterventions.

Comparison:Conservativemanagementanddelayedinterventionapproachesforliver-specificcomplications Outcome:Ratesofinfectiveandothercomplications(eg,bileleaks,abscessformation)post-intervention

PrimaryObjective

Toassessmanagementandoutcomesfollowingmajorbluntlivertrauma.

StudyDesign:

ThisretrospectiveobservationalstudywillincludedatafromAustralianlevel-1traumacentresonpatientswithbluntliver traumafrom2014-2024.Eligiblepatientswillbeidentifiedviaelectronicmedicalrecordsortraumadatabases.

Inclusioncriteria:

Adultpatients–18yearsandabove

Mechanism:bluntliverinjury–AASTGrade3andabove,oroperativefindingofliverinjurywithoutpriorimaging

Potentialleadinvestigatorswillbeapproachedateachlevel-1traumacentre,whowillberesponsibleforoverseeingthe datacollectionprocess.Leadinvestigatorswillsecureethicsapproval,recruitupto10teammembersfordatacollection, andcoordinateacrosskeysurgicalunits(hepatopancreaticobiliary,generalsurgery,upperGI) Dataextractedwillinclude demographics,overallinjuryseverityscore,liverinjuryseverity(basedontheAASTliverinjuryscale),interventions,overall outcomes(Clavien-Dindocomplications,theneedforfurtherproceduralintervention,mortalityandlengthofhospitalstay) andliverspecificoutcomes(abscess,bileleak)&interventions(percutaneousdrainage,resectionaldebridement,ERCP). StandardisedformsinREDCapwillenableuniformdataentryandvalidationacrosscentres,whileacentralteamwillreview dataforaccuracy Centralisedstatisticalanalysiswillidentifyriskfactorsforcomplications,particularlyregardingERCP timing,andsubgroupanalyseswillassessinjurygradesandadjuncttreatments.

Awards

TheSurgicalResearchSocietyofAustralasiaconferencehasmultipleawardsavailabletoeligible presenters.

Theseare:

ProteomicsInternational,YoungInvestigatorAward:OneAUD4,000prizeisawardedtoapresenterless than10yearspostfellowship.TheYoungInvestigatorAwardprovidesfundstosupporttheattendanceand presentationattheAcademicSurgicalCongress(ASC)intheUSAin2025.

ANZChapteroftheAmericanCollegeofSurgeons:OneAUD2,000prizeisawardedtoapresenterwhohas beenaFellownotmorethan5years.TheANZChapteroftheAmericanCollegeofSurgeonsAwardrequires theAwardeetopresenttheirresearchattheANZChapterSurgicalForumattheRACSAnnualScientific Congressthefollowingyear.

NovemberAnnualAcademicSurgeryConferenceTravelGrant-HigherDegree:Prize:(AUD1,000each)is awardedtoapresenterwhoisundertakingahigherdegreebyresearch TheTravelGrantfundsexpenses towardstravel,accommodationandconference/courseregistration

NovemberAnnualAcademicSurgeryConferenceTravelGrant–Clinical:Prize(AUD1,000each)isawarded toapresenterwhomustbeaSETTrainee,Pre-vocationalDoctororMedicalStudent TheTravelGrantfunds expensestowardstravel,accommodationandconference/courseregistration

ElseviereBookVouchers:ElsevierhavegenerouslydonatedthreeBookvouchersvaluedatAUD150each Theseprizeswillbeawardedtothebestvisualpresentationineachcategory(oralandposterpresentation) aswellasthetopEarlyCollaborativeStudyIdeaspresentation Allpresentersareeligibleunlesstheyhave alreadyreceivedanawardduringtheconference,orasotherwisecommunicated

ResponsibilitiesforWinners:Allawardandprizewinnersaretosubmita300wordreporttotheAcademic SurgeryCommitteewithin12monthsdetailingtheirlearnings,andanyresultingcollaborationsand/or publications/presentations

AboriginalandTorres StraitIslandermotif

TheMāorimotif indicatesRACS’ commitmentto addressMāorihealth inequitytoaccept obligationsinherentin teTiritioWaitangi

AboriginalandTorres StraitIslandermotif

TheAboriginaland TorresStraitIslander motifindicatesRACS’ commitment toaddressAboriginal andTorresStrait Islanderhealth inequity.

SectionofAcademicSurgery

Doyouhaveaninterestinacademicsurgery?

Eligibility

MembershipoftheSectionofAcademicSurgeryisopentoFellows,Traineesand InternationalMedicalGraduates(SIMGs)onapathwaytoFellowshipwhohaveaninterest inacademicsurgery TheExecutiveCommitteeoftheSectioncanalsooffermembershipto individualswhoareexternaltotheCollegeonrecommendationfromtheChair.Non Collegemembersmayhavetopayamembershipfeebutwillnothavevotingrightsand arenoteligibletoholdgovernancepositions.

ObjectivesoftheSection

TodevelopandmonitorstandardsinacademicsurgicaldepartmentsinAustraliaand AotearoaNewZealand

Toenhancecareerpathwaysinacademicsurgeryandtoencourageyounger surgeonstopursueopportunitiesinacademicsurgery

TodevelopanAustralasiancurriculumforundergraduatesurgery,toprovideadviceto AustralianandAotearoaNewZealandmedicalschoolsregardingappropriatesurgical content,andwhichisappropriateforcontinuationtosurgicaleducationandtraining ToadviseRACSCouncilonprofessionalandpolicyissuesrelatedtoacademicsurgery, aswellasissuesofrelevancetosurgeryingeneral

TorespondtorequestsfromCouncilforconsiderationofrelevantissues.

Toestablishandmaintainaregistryofacademicallyactivemembersinorderto supporttheSection'sactivitiesandplanappropriateworkforceissues.

Governance

TheSectionofAcademicSurgeryisgovernedbytheAcademicSurgeryCommittee reportingtotheResearch&AcademicSurgeryCommittee(RASC)andtheProfessional StandardsandFellowshipServices(PSFS)Committee.

Submittinganapplication: Doyouhaveaninterestinacademicsurgery?Tojointhecommunityofacademicsurgeonstodayforfree,simply completethisapplicationform.Moreinformationcanbefoundhere