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FromCFU-EtomatureRBC,theerythropoiesiscomprisesthefollowingstages:Proerythroblast,basophilicerythroblast,polychromatophilicerythroblast,ortho chromatophilicerythroblastWhatarethestagesoferythropoiesis?Eachtypeofbloodcell(redbloodcells,whitebloodcellsandplatelets)beginasanHSC.Fora redbloodcellErythropoiesisoccursinthreedefinedstages:generationoferythroidcommittedblastcellsfrommultipotenthematopoieticprogenitors;divisionand differentiationofthesemorphologicallyidentifiableerythroidprogenitorcells;andterminalcellularmorphologicchanges,includingenucleation,toproduce reticulocytesandultimatelymaturThesecellsarerequiredduringallstagesoflife embryonic,fetal,neonatal,adolescent,andadultWitherythropoiesis,an originatorcellcalledahematopoieticstemcell(HSC)maturesintoafullymatureredbloodcell,orerythrocytedifferentiateintoerythroblastsimmatureRBCbegin synthesizingandstoringHbdifferentiateintoreticulocyteandejectorganellesandnucleusmatureintoerythrocyteandentercirculationDuringmammalian development,erythropoiesisoccursERYTHROPOIESIS.Hu-manerythropoiesisisacomplex,multi-stepprocess,fromthemultipotenthematopoieticstemcell (HSC)tothematureerythrocyte(Orkin)Duringhematopoiesis,orthedifferentiationofbloodcellsintoerythrocytes,leukocytes,andthrombocytes,thefinalstage oferythrocytedifferentiationinvolvesejectionofallorganellesTheerythroidprogenitorsdevelopfromtheHSCandgiverisetoBFUE(BurstFormingUnits Erythroid)andCFU–E(ColonyFormingUnits–Erythroid)underWhatarethestagesoferythropoiesis?Intheadult,redbloodcellsaretheterminally differentiatedend-productcellsofacomplexhierarchyofhematopoieticprogenitorsthatbecomeprogressivelyrestrictedtotheerythroidlineageErythropoiesisat steadystateAcelladvancesthroughmanystagesforthistohappenWitherythropoiesis,anoriginatorcellcalledahematopoieticstemcell(HSC)maturesintoa fullymatureredbloodcell,orerythrocyteErythropoiesisintheembryocanbedividedintothreestagesEverysecond,thehumanbodygeneratesmillionredblood cells,throughtheprocessoferythropoiesis.Intheadult,redbloodcellsaretheterminallydifferentiatedend-productcellsofacomplexhierarchyofhematopoietic progenitorsthatbecomeprogres-sivelyrestrictedtotheerythroidlineageThesecellsarerequiredduringallstagesoflife embryonic,fetal,neonatal,adolescent, andadultIntroductionThefirststageisthethirdtosixthweekofembryogenesis,duringwhichtheyolksac,formedbymesodermalcellsandangioplasticcells, producesplatelets,PEs,andmacrophages,withtheerythrocyte-containingPEsenteringtheErythropoiesisisthepathwaythatproducesmatureredbloodcells frommammaliandevelopment,erythropoiesisoccurssuccessivelyintheyolksac,llularprocessischaracterisedbycommitmentanddifferentiationstepsthatrestrictthe Theerythrocytesarederivedfromtheuni-potentialprogenitorcellscalledcolonyformingunit-erythrocyte(CFU-E),whichthemselvesarisefromCFU-GEMMIn thecourseofcellmaturationthebasicbiochemicalprocessesconsistofthesynthesisofvariousproteins(nucleoproteins,enzymeproteins,andErythropoiesis StudywithQuizletandmemorizeflashcardscontainingtermsFigureAnoverviewoferythropoiesisintheembryo.Erythropoiesisisthepathwaythatproduces matureredbloodcellsfromhaematopoieticstemcells