Impact Magazine 2008 by OSUPublicHealth

IMPACT The Research Magazine of The Ohio State University College of Public Health

Inside this issue: • Fighting cancers affecting women • Tracking STDs in incarcerated men • Biostatistics and a history lesson • Champions of Public Health

2008

Table of Contents 1 Dean’s message 2 News from the Ofﬁce of Research Communications Ofﬁce Christine O’Malley, communications director Wendy Pramik, communications coordinator

3 Putting up a ﬁght against cancer

Publication design by The Drawing Room Ofﬁce of Research Mary Ellen Wewers, associate dean of

6 Sowing the seeds of health with funding

research and faculty development Katrina Gustafson, grants manager Kathy Renick, grants manager Photo credits:

9 No link found between night shift and increased cancer tisk

All head shots are credited to University Photography; stock photography from Shutterstock. Other images: p. 13 courtesy of Ohio Historical Society; p. 12 and p. 18 communications staff. Impact Magazine is published annually by the OSU College of Public Health for the alumni, faculty, students, staff and friends of the College. This is the third issue. Copyright 2008. Permission to reprint any portion must be obtained from the College. Contact: College of Public Health Communications Ofﬁce, 320 W. 10th Ave., Starling-Loving M101, Columbus OH 43210. Phone: (614) 293-9406. On the web at http://cph.osu.edu “Advancing Knowledge. Improving Life.”

Support Public Health To support what public health research can do, consider funding student scholarships or contributing to our research funds. For more information on giving to the College, contact our development ofﬁce at (614) 293-7628.

10 Asking tough questions about prisoners’ STDs

p.3 Cervical cancer research

11 Hearing loss linked to pesticides 12 Biostats prof measures history lesson 14 Faculty news

p. 10 Research surveys prisoners on STDs

17 Student news 19 Public health champions celebrated 20 Faculty publications 24 Grants and contracts

p.11 Pesticides linked to hearing loss

Health is not a solo act Public health is about making the world around us a healthier and safer place. Investing in public health helps everyone, and the failure to do so exposes every citizen to increased risks from threats such as pandemic influenza, natural disasters and preventable health conditions. Public health is a field that demands collaboration and breaks barriers. Researchers in the College of Public Health are uniting with other health professionals to find solutions to today’s health problems. Some are working to understand why exposure to certain pesticides is putting farmers at risk for hearing loss. Others are trying to help women fight their battles with cancers long before their first symptoms surface. Still others want to know how to stop an infectious disease, such as MRSA, from spreading between animals and humans. As you will see in this magazine, we have faculty, students and alumni who work on problems like this every day in order to make the world a better place. The public health research being conducted today and the future generations of researchers we are training are the promise of tomorrow. Two significant sources of research funding for the college, the Centers for Disease Control and Prevention and the National Institutes for Health, have been given 2008 budgets that do not keep pace with inflation. This severely limits the exploration and trailblazing that has distinguished American research for generations. Look at the public health milestones of the past 100 years and you’ll notice that they all originated with research. Last fall, the college hosted the Milestones of Public Health exhibit sponsored by Pfizer Inc. and the Association of Schools of Public Health. The exhibit, featured in this magazine, highlighted 11 significant discoveries made in public health during the last 100 years. Topics included vaccines, oral health, infectious disease control, automobile safety and cardiovascular disease. What will be the public health milestones for the next century? How will we reach these goals without adequate funding? I am unsure that our government will continue to support research at a level that keeps this country on track. However, we remain committed to finding alternative sources of research funding, so that this century will see as much progress as the last one. We also realize that we cannot do this alone. Health is not a solo act. It reflects how we live, what we eat and drink, and where we work and play. We are only as healthy as the world we live in, so join us in making a difference. Help Ohio State do something great!

Advancing Knowledge. Improving Life.

Dean’s Message

Dean Stanley Lemeshow

Impact Research Magazine

News from the Ofﬁce of Research

Progress means student opportunities, increased funding We’ve just celebrated our first anniversary in the College of Public Health’s Office of Research! With the start of our second year, I’m pleased to announce a new and important college initiative focused on undergraduate research. Dean Lemeshow has made available college funds for faculty to recruit undergraduates to their research teams. This past December, six faculty members successfully competed for college funds to appoint gifted undergraduate students to participate in faculty research projects. The successful faculty are: Ann McAlearney, Sharon Schweikhart, Michele Shipp, Amy Ferketich, Judy Schwartzbaum and Qinghua Sun. For more about these awards see the article in the Student News section of this magazine. We were excited by the number of undergraduate students who applied for these positions. As a college, we are eager to provide opportunities that will attract undergraduates to public health research. Our seasoned and talented grants management staff includes two full-time grant program coordinators, Katrina Gustafson and Kathy Renick. As of February 2008, our annualized college total funded research expenditures were estimated at $5,418,000. Given this outstanding accomplishment by faculty, students, and staff, our office has recently restructured activities to streamline grant submission and management processes. Katrina and Kathy are now assigned to manage both pre- and post-award responsibilities, according to divisions. We believe this mechanism provides for better continuity and allows for a sustained working relationship with faculty. We intend to evaluate the effectiveness of this approach in the coming year. In addition, our office now is represented on the newly formed University Administrative Research Council (ARC). ARC brings together administrative personnel, like Katrina and Kathy, who are involved in grants management across the university. ARC will promote information exchange, education and training, grants policy and procedure development, process improvement, and other activities that support faculty research and scholarship. ARC members are dedicated to serving faculty researchers and enhancing Ohio State’s research environment. I look forward to reporting further on these projects in the coming months. Mary Ellen Wewers is the associate dean for research and faculty development. She is also a professor in the College’s division of health behavior and health promotion.

College of Public Health faculty battle cancers affecting women By Wendy Pramik CPH Communications

Advancing Knowledge. Improving Life.

Ready for a ﬁght

Breast cancer, lung cancer, cervical cancer. They’re among the most-proliﬁc killers of women in the United States. They’re also among the biggest targets of research at the College of Public Health. Research to discover why and how the cancers affect women, and how they can be prevented, is ongoing at the College. Whether it’s helping to stop women from smoking, intervening to help them eat better or isolating cancer genes, researchers say it’s perhaps the most-rewarding work they can imagine. “All of us doing this kind of research have a real opportunity to make a signiﬁcant impact on peoples’ lives,” said Christopher Weghorst, associate professor in the Division of Environmental Health Sciences. “Every day I ride the elevators with patients and families who are going through the ordeal of cancer. It really provides a tremendous amount of motivation.” Here’s a sampling of some of the cancer research taking place at the College: 3

Impact Research Magazine

Christopher Weghorst Associate Professor, CPH Division of Environmental Health Sciences

Electra Paskett Marion N. Rowley Professor of Cancer Research

Cervical Cancer

Breast Cancer

Weghorst wants to apply the brakes to the spread of cervical cancer. Weghorst is leading a two-year study to determine if heredity plays a role in why women in Ohio’s Appalachian region contract the disease at a rate 24 percent higher than other U.S. women. The study, entitled “Genetic Susceptibility and Cervical Cancer Development,” involves researchers from the College of Public Health’s Division of Environmental Health Sciences, the College of Medicine and The James Cancer Hospital and Solove Research Institute. Weghorst’s study will focus on a variant of a gene that has been shown to increase one’s risk of developing cancer. Weghorst says the common version of the gene functions as a brake in cooperation with other proteins to send signals that inhibit cell proliferation. In contrast, the variant of the gene has a small deletion that causes the braking function of the resulting protein to be decreased. This decreased braking leads to increased cell proliferation and an increased risk of cancer development. “We want to ﬁnd out if the gene variant puts affected women at risk for cervical cancer development and is over-represented in groups considered to be at ‘high risk’ for developing cervical cancer, like Appalachian women.” Weghorst said. “These studies will not only expand our knowledge of the molecular mechanisms of this disease, but also provide a foundation from which we can rationally design intervention strategies.” Weghorst’s team will evaluate DNA from two cervical cancer patient groups: women in the Midwest and women in Appalachian Ohio. Weghorst will collaborate with Dr. David Cohn from Ohio State’s Department of Gynecologic Oncology, and Electra Paskett, professor of cancer research in CPH’s Division of Epidemiology. The study is sponsored by Phi Beta Psi, a national, nonacademic sorority that has donated $5.6 million in grants to cancer research since 1973 when their Charity Trust Fund was established.

Electra Paskett believes nutrition goes hand in hand with breast cancer prevention. “We’re trying to give women some alternative options for prevention of breast cancer rather than taking a pill,” said Paskett, professor of cancer research in the Division of Epidemiology and a two-time breast cancer survivor. Paskett is the principal investigator of a research project called “Evelyn Lauder Breast Cancer Prevention Through Nutrition Program.” Funded by the Breast Cancer Research Foundation, the project examines the roles that nutrients, food intake, exercise and body weight have on women with a high risk for the disease. The program has four studies: • How tomato and soy products affect biomarkers of risk in post-menopausal women. • A trial of low-fat vs. low-carbohydrate diets plus exercise in overweight, pre-menopausal women to see how weight loss affects biomarkers of risk. • If motivational messages delivered by cellphone can encourage weight loss in post-menopausal women. • How energy balance, which is diet and exercise, impacts the recurrence of breast cancer in survivors of the disease. Paskett’s current research focuses on prevention, early detection and survivorship issues. She is principal investigator of several studies including why women in Appalachian Ohio have high cervical cancer rates, a study on using intervention techniques to prevent lymphedema in breast-cancer patients, and a study examining issues long-term breast cancer survivors face. “I really enjoy what I do,” Paskett said. “I don’t do straight epidemiology in terms of what causes cancer. I take what others have done and develop interventions to try to get people to change their behaviors or adopt a behavior so that they either don’t get cancer, detect it early or, if they have had cancer, then live as best a quality of life as they can.”

Advancing Knowledge. Improving Life.

Lung Cancer and Women Lung cancer kills more women than any other kind of cancer. Part of the reason is the late stage at diagnosis, says Mary Ellen Wewers, professor in the Division of Health Behavior and Health Promotion. Wewers is conducting a study within the “Early Prevention, Detection and Treatment of Lung Cancer Trial” which includes a sub-study designed to encourage smokers to quit. Wewers believes that smokers need to be more proactive in seeking out medical assistance for nicotine dependence. “One of the reasons people die of lung cancer is because there’s no cost-effective screening test,” she said. “Generally lung cancer is diagnosed at a later stage when it’s more difﬁcult to treat, therefore the increased mortality rate.” Wewers’ study is being conducted through OSU’s Comprehensive Cancer Center, with Michael Caligiuri, MD, as principal investigator. Caligiuri received a grant from the state of Ohio to study early prevention, detection and treatment of lung cancer. Working in a public health clinic in Zanesville in Muskingum County, Wewers’ team asked smokers coming in for routine visits to view a computer tablet that described their behavior.

Wewers was searching for ways to inspire smokers to seek treatment for their nicotine dependence. She recruited 170 smokers and is currently analyzing the data. The study ends in August. Wewers, a nurse practitioner, is hoping that clinic aids, such as a computer tablet, will increase smokers’ awareness of effective treatment options. “We’re trying to encourage smokers to be more proactive in getting to their physicians for treatment. We just need to give them the information and the skills to go ahead and ask their doctors to help treat their nicotine dependence,” she said. Weghorst, Paskett and Wewers all agreed that they enjoy working in an environment where so many are contributing research toward ﬁnding cures to devastating diseases, such as cancer. “I think it’s pretty exciting,” said Paskett about her work in the College of Public Health. “We need more cancer researchers.” ■ Mary Ellen Wewers

Impact Research Magazine

Sowing the seeds of health Infectious disease seed grants lay groundwork in hotbeds of research By Wendy Pramik CPH Communications

Chickens, snails, even puppy-dog tails. That’s what some of the College of Public Health’s newest research projects are made of. These subjects can all be found among four studies that were recently funded by seed grants from OSU’s Public Health Preparedness for Infectious Diseases (PHPID) initiative. The grants fund public health research on the avian flu, the role that snails play in the transmission of a deadly disease in a Chinese lake, the spread of MRSA among dogs, and the development of a computer-simulation training lab for public health practitioners. PHPID is a collaborative of six colleges that addresses infectious disease threats, such as pandemics, bioterrorism, food-borne illnesses and natural disasters. The six colleges are: Biological Sciences; Food, Agricultural, and Environmental Sciences; Medicine; Pharmacy; Public Health; and Veterinary Medicine. The seed grants are valued at $50,000 each and are renewable for a second year, bringing the total to $100,000 for two years. The studies represent the College’s ongoing effort to grow new lines of research and increase funding. “Pilot studies serve a very important purpose in providing investigators the opportunity to generate preliminary data,” said environmental health professor Timothy Buckley, who’s leading such a study on the avian flu. “They highlight the significance of the research to excite and motivate reviewers to rank your proposal ahead of the competition.” This year, PHPID funded five pilot projects, four of which are being led by investigators in the College of Public Health. Here is a closer look at the four pilot studies.

Preparing for an avian influenza pandemic Project duration: November 2007 through June 2009 The threat of an avian flu pandemic is nothing to balk at, says Buckley. Preparing for an outbreak and preventing the disease from spreading is critical since avian influenza is a rapidly mutating virus that kills 70 percent of infected people. “The trick is not to wait for it to become a crisis, because it’ll be too late,” Buckley said. “The threat is real, and the time is now.” Buckley is leading a two-year pilot study on how to prepare the public for an outbreak of this deadly disease. His team plans to study airborne virus detection and inactivation using Newcastle Disease Virus as a surrogate. This virus has many similarities to avian influenza virus, including its size, structure and mode of transmission. Although Newcastle Disease Virus is deadly to poultry, Buckley will use the strain from vaccines that poses little or no risk to humans. The study will proceed in two phases. The first phase will be conducted under controlled conditions in the laboratory. The second phase will be conducted with human volunteers at the animal research facilities at the Ohio Agricultural Research Development Center (OARDC) campus in Wooster. Buckley will arrange for a group of volunteers to be exposed to the harmless Newcastle Disease Virus. Some of the volunteers will be exposed in a room with UV lighting, that will be tested as a means to inactivate the virus. In addition to looking for virus antibodies in the volunteers, Buckley will collect and quantify the virus samples in the air before and after UV radiation. This study is a collaboration with Mo Saif and Chang-Won Lee, faculty in Ohio State’s animal agriculture program. “The major goal is to develop the applied science for detecting airborne virus and preventing inhalation exposure,” Buckley said.

Advancing Knowledge. Improving Life.

Timothy Buckley

Armando Hoet

The spread of MRSA among dogs Project duration: December 2007 through November 2008 Armando Hoet, an assistant professor with a joint appointment in the Colleges of Public Health and Veterinary Medicine, is leading a pilot study on the spread of a multidrugresistant strain of Staphylococcus aureus called MRSA between animals and humans. Often referred to as a superbug, MRSA is resistant to multiple antibiotics commonly used to treat Staph infections. It’s especially troublesome in human hospitals, where patients with weakened immune systems are at greater risk for infection than the general public. During the past 10 years the number of MRSA cases has increased, according to the Centers for Disease Control and Prevention. Symptoms can range from a small skin rash to kidney failure, which can lead to death. MRSA infections are now responsible for more deaths each year than AIDS. Animals also can contract MRSA. “In the last few years, we’ve seen an increase in the cases of MRSA infections in dogs, cats and horses,” said Hoet, who is a veterinarian specialized in zoonotic diseases, which can be passed from animals to humans and vice versa. “We don’t know if that’s because there’s been an increase in MRSA in humans and it’s spilling over to the animal side or if it’s because our animals are facing similar risk factors that predispose them to MRSA infections as occurs in humans.” Hoet’s yearlong study unites researchers in the College of Veterinary Medicine, College of Public Health and College of Medicine. They’ll examine the prevalence of MRSA in the OSU Medical Center and the OSU Veterinary Teaching Hospital, and compare the isolated strains of MRSA from humans and canines. As part of this study, 432 dogs brought to OSU’s vet hospital for routine visits will be sampled. If the strains are the same, it could mean that humans are passing the infections to animals. If the animals have their

own strain, it could mean that this zoonotic MRSA (ZAMRSA) could jump to the human side and produce a zoonotic disease. “This will cause an additional headache in regards to the MRSA problem that already exists,” Hoet said.

Schistosomiasis in Poyang Lake Project duration: December 2007 through December 2009 Poyang Lake, located in Jiangxi Province, is the largest freshwater lake in China. Known for attracting millions of migratory birds, the picturesque body of water also is a giant breeding ground for a deadly parasite called Schistosoma, which lives in a speciﬁc type of snail in the water. More than 100,000 people and 9,000 head of cattle in this area annually acquire schistosomiasis, or “snail fever,” after coming in contact with infected snails. The disease has a low mortality rate, but it can cause severe liver and intestinal damage. Song Liang, assistant professor in the College’s Division of Environmental Health Sciences, visits the Poyang Lake region twice a year to study the parasite. “I am interested in how environmental changes inﬂuence schistosomiasis transmission and public health,” Liang said. Liang’s most-recent study focuses on the Three Gorges Dam, a hydroelectric dam that spans the Yangtze River. The dam has been in the works since 1994, and the project is expected to be complete next year. Liang will lead a group of researchers to explore the environmental impact of the 7,661 foot-long dam, the construction of which forced the relocation of more than 1 million people. “We hypothesize that the dam and land conversion-induced water level change and human resettlement will alter the spatial and temporal distribution of snails, cattle and human activity such that schistosomiasis incidence increases in the 7

Impact Research Magazine

Song Liang

Adam Negley

region,” Liang said. Liang’s current study shifts focus from the mountainous regions of China, where his team previously sought to understand why the disease reemerged in an area where it was previously controlled or eliminated, to the lower Yangtze region, where the parasite is adjusting to its new change in environment. “At the completion of this study, we expect to have concrete information about the impact of the dam on schistosomiasis,” Liang said.

Computer-simulation lab for practitioners

John Crawford

professionals nationwide.” Public health practitioners are required to regularly complete training courses so their agencies can comply with health codes. Since the 2001 terrorist attacks in New York, more disaster training is required. Meeting training requirements can be time-consuming, especially for small, understaffed health departments. Crawford said the Web-based module will allow practitioners from different locations around Ohio to develop action plans in response to simulated disasters, such as infectious disease outbreaks. These participants will use an online gaming environment to meet and plan the response. Other participants will receive a standard PowerPoint-based table-top exercise. Participants will be randomly assigned to the two simulations. Follow-up studies will compare attitudes and beliefs of health practitioners who participated in computer-simulation methods with those who participated via PowerPoint presentations. “We want to see if the collaborative, interactive exercises stick with them a little better,” Crawford said. The pilot training module is expected to be ready by June 2007, and the exercise simulations are to be ready by November. Recruitment of 70 practitioners will begin in 2009. ■

Project duration: November 2007 through November 2009 Faculty and staff in the College’s Office of Workforce Development are creating a virtual training laboratory to help Ohio’s 134 health departments respond to emergencies. A computer simulation training method could make the center’s sessions more “effective, efficient and enjoyable,” said Adam Negley, assistant director of the Office of Workforce Development, which oversees the preparedness center. The majority of its classes are now taught in the center’s classrooms, others are taught on site. Negley is part of a research team headed by principal investigator John Crawford that is developing the virtual training lab. The team also includes the College of Veterinary Medicine, the College of Medicine and the Ohio Supercomputer Center, which will design the computer program. “This simulation laboratory will not only meet a critical training need for the region,” Crawford said. “It will provide a model for development — John Crawford, of other training modules for Assistant Professor, CPH Division of Environmental Health Sciences first responders and other health

“This simulation laboratory will not only meet a critical training need for the region, it will provide a model for development of other training modules for ﬁrst responders and other health professionals nationwide.”

Advancing Knowledge. Improving Life.

No link found between night shift and increased cancer risk By Holly Wagner OSU Research Communications

Working the night shift doesn’t appear to increase the risk of developing cancer, suggests the ﬁndings of a new study of Swedish workers by a CPH epidemiology professor. This contrasts with other recent studies that suggest regularly working the night shift may increase the risk of developing breast, prostate and colon cancers. Some researchers say that the connection could be due to a decrease in the production of the hormone melatonin, as some animal experiments suggest that the hormone may have anti-cancer properties. Our bodies produce their highest levels of melatonin at night, during sleep, but exposure to light at night suppresses melatonin production, said Judith Schwartzbaum, the study’s lead author and an associate professor of epidemiology in the College of Public Health. “However, the effects of melatonin on cancer development in humans are not well understood,” she said. Schwartzbaum and her colleagues found no link between working the night shift and the risk of developing any kind of cancer. They came to this conclusion after analyzing nearly 20 years’ worth of data that compared people who reported jobs that required working during the day to people who said they had jobs that required night shift work. The ﬁndings appeared in the Scandinavian Journal of Work, Environment and Health. Schwartzbaum conducted the study with researchers from the Institute for Environmental Medicine, located at the Karolinska Institutet in Stockholm, Sweden. The study included all Swedish citizens who worked at least 20 hours a week in 1970, and who were included in both the 1960 and 1970 population censuses – a total of about

3.2 million people. The researchers collected information on the people from 1971 through 1989 or until a worker was diagnosed with cancer or died. The researchers looked for workers with jobs that met the criteria for night-shift work in both the 1960 and 1970 censuses. Schwartzbaum and her colleagues defined shift work as work that had a rotating schedule with three or more possible shifts per day, or where the schedule included working between 1 and 4 a.m., which the researchers defined as working at night. A very small percentage of the working population included in this study reported having jobs that met the definition of shift work (just 4 percent of men and 0.4 percent of women.) The final results showed no relationship between shift work and an increased risk of developing prostate, colon or breast cancers or nearly any other kind of cancer, regardless of how much the occupation depended upon shift work. Schwartzbaum points out that the current results don’t agree with a number of recently published studies. What’s needed, Schwartzbaum said, are large-scale international studies to help tease out the relationship between shift work and the risk of developing cancer. “It seems like 3 million workers ought to be enough to get a firm idea of the risk, but it isn’t, especially considering the relatively low percentage of jobs that require shift work,” Schwartzbaum said. “We need studies that include data from multiple countries.” ■

Judith Schwartzbaum 9

Impact Research Magazine

Asking tough questions Survey aims to provide insight on sexual health risks of incarcerated men By Wendy Pramik CPH Communications

Researchers in the College’s Center for Health Outcomes, Policy and Evaluation Studies (HOPES) have developed a survey designed to provide insight into the sexual health risks faced by incarcerated men. Survey responses will help prison officials find ways to better protect prisoners from contracting sexually-transmitted illnesses. The Center for HOPES’ research team, led by Director Allard E. Dembe and Senior Researcher Cynthia Sieck, created the 34-question survey for the Ohio Department of Rehabilitations and Corrections, which is funding the project. The bureau hopes to learn what risky behaviors are going on behind bars at the Mansfield Correctional Institution, a levelthree facility for felony offenders. Sexually-transmitted diseases are often spread by sexual activity, but they also can be spread by sharing needles, tattooing and violent assaults. “We hope to collect new information that has never been collected in Ohio before about the kinds of risks that are faced by prisoners,” said Dembe, associate professor and chair in the Division of Health Services Management and Policy. “We believe our survey is one of the most comprehensive and informative surveys of its type that has been done in the U.S.” Allard Dembe The prison houses approximately 2,400 inmates. Prior to entering the prison, every inmate is given a blood test to check for sexually-transmitted diseases including syphilis, gonorrhea, genital herpes and AIDS. Six weeks before their release date, prisoners at the Mansfield Correctional Institution are required to take another blood test to see if they contracted an STD while incarcerated. Prisoners who test positive for STDs receive medical care. Those who test positive just prior to their release date also will receive access to follow-up care outside of prison. 10

In setting up this pilot project, the Ohio Legislature mandated that prisoners be tested for sexually transmitted illnesses. The Center for HOPES suggested that each prisoner also have an opportunity to take the confidential survey before being discharged from prison. The survey asks inmates about their sexual behavior, tattooing and drug use while in prison. For example, one question asks: “Did you use some kind of barrier protection other than a condom when you had sex?” Response options are: “None; latex or rubber gloves; plastic wrap; and other.” For six months, the research team worked closely with the prison’s employees and medical staff to develop relevant questions for the survey. “Most prisoners have a positive attitude about this study, because they understand the reason for doing it is to ultimately prevent disease and injury,” Dembe said. A further detail for the research team was to direct how the survey would be administered. “We had to ensure that the nurse administering the survey was available to answer the prisoner’s questions, and, at the same time, ensure that a corrections officer would be close enough to what’s happening to intervene if needed without breaching the confidentiality of the prisoner’s responses,” Dembe said. As of January, more than 100 inmates have completed the survey, which is being conducted from November 2007 through November 2009. About 1,500 inmates are expected to be released during that timeframe. “Based on previous studies, prison officials believe there is little likelihood that prisoners are acquiring STDs in prison,” Dembe said. “The survey will give a good idea of the risk factors existing in Ohio prisons, and ways of minimizing those risks.” ■

Study backs up suspicions linking pesticides and hearing loss

Advancing Knowledge. Improving Life.

Hearing aide

By Wendy Pramik CPH Communications

John Crawford recently warned students in his environmental health class of the dangers of listening to loud music on their iPods. “You wouldn’t stare into the sun, would you?” Crawford, an assistant professor in the College’s Division of Environmental Health Sciences, believes hearing loss is a widespread problem that’s growing. So when a colleague at the National Institutes of Health asked for help with a study on the relationship between hearing loss and agricultural pesticides, Crawford eagerly agreed to analyze data. In the study, called “Hearing loss among licensed pesticide applicators,” Crawford collaborated with researchers from the National Institute of Environmental Health Sciences and the National Cancer Institute to seek a link between hearing loss and the use of pesticides. Hearing loss is commonly associated with noise exposure, head trauma and the body’s natural aging process, Crawford says, but a growing body of evidence also links it to chemical exposures. “The biggest risk is to the workers who use chemicals,” Crawford says. “That’s why we’re interested in studying workers because they have more intense exposures compared to the general population.” Crawford, who’s worked and studied at OSU since 1983, pored over data collected from 1993 to 1997 through the Agricultural Health Study, conducted by the National Institutes of Health. Five years later, follow-up calls were conducted with many of the participants. The result: Thirty-ﬁve percent of white male pesticide applicators in Iowa and North Carolina from 1999 to 2003 reported hearing loss. Crawford adjusted for state, age, noise, and exposure to solvents and metals. “This is one of the largest studies of its kind,” Crawford says. “Our study included more than 14,000 subjects. It has a lot of power.” The study concludes that exposure to organophosphates, a

subcategory of insecticides, increases the risk of hearing loss. “There are several classes of pesticides,” Crawford said. “Herbicides kill plants, fungicides kill fungi, and insecticides kill insects. Insecticides seem to have the strongest relationship to hearing loss. There’s roughly a 20 percent increase in the odds of hearing loss among those more highly exposed to them.” The ﬁndings of Crawford’s study will be published in 2008 in the Journal of Occupational and Environmental Medicine.

“The biggest risk is to the workers who use chemicals.” — John Crawford, Assistant Professor, CPH Division of Environmental Health Sciences

“We’re not going out and saying that these insecticides are causing hearing loss,” Crawford says. “But it’s one study that supports the hypothesis that these chemicals can affect hearing. “Better studies that measure hearing loss and noise and chemical exposures objectively are needed to solidify our understanding of these complex relationships.” ■ 11

Impact Research Magazine

History lesson Biostatistics professor helps Ohio Historical Society show effectiveness of program By Wendy Pramik CPH Communications

Assistant Professor Bo Lu, pictured at the Ohio Historical Society, assisted the society in analyzing data about National History Day.

When researchers at the Ohio Historical Society in Columbus wanted to show the effectiveness of an alternative history program for students in grades 6-12, they sought the help of biostatistician Bo Lu. Lu, assistant professor in CPH’s Division of Biostatistics, helped analyze data to compare student learning outcomes across different groups. The Historical Society wanted to see if students who participated in the year-long, interactive program called “National History Day in Ohio” appreciated and benefited from learning history more than their classmates who did not participate in the program. Lu’s findings give researchers the evidence to boast about their program. “Students participating in National History Day in Ohio received significantly higher scores on their Ohio Graduation Tests for social science, reading and writing,” said Giuseppe Monaco, evaluation analyst at the Ohio Historical Society. “Furthermore, they demonstrated a deeper appreciation of history and a better ability to explore and integrate new perspectives.” National History Day is a national competition for students in grades 6-12. Students research topics related to an annual theme and present their conclusions in exhibits, performances, documentaries or historical papers. Students 12

compete at regional, state and national levels. The national competition, held in Washington D.C., awards cash prizes and college scholarships. The program started out as a local contest in Cleveland in 1974 and has grown nationally to include more than two million participants. Despite its long history, few studies have evaluated the program’s impact on students. Monaco designed the evaluation project and, together with Megan Wood, state coordinator for National History Day in Ohio, developed the pilot study in 2007. They compared students who participated in the program with those who didn’t participate using the Ohio Graduation Test as one of the measuring sticks. They hope their test model will be adopted by other institutions. Monaco and Wood enrolled 109 tenth-graders from public schools in Columbus and Dayton to take part in their pilot study. Fifty-seven of the students participated in National History Day in Ohio during the 2006-07 school year. The theme of the program that year was “Triumph & Tragedy in History.” The remaining 52 students who did not participate were labeled the control group. They recruited Lu to help analyze the data, since conventional statistical methods for estimating the treatment

learning history both in the classroom and during everyday life. After coding the students’ responses to the open-ended questions, themes were reported as “prominent,” “important,” “present” or “absent.” The researchers calculated the statistical signiﬁcance of the different responses to the closed-ended questions between participants and controls. The result showed that both groups viewed the subject of history as an education of important events in our past. The control group, however, demonstrated an “I take this because I have to” attitude that wasn’t present in the group who had participated in National History Day in Ohio. Responses from the participating group revealed a more positive attitude toward the subject of history, and included comments such as “it’s important,” “I like it,” and “it’s easy.” Development of critical thinking was evaluated during focus group discussions. Students were shown a photograph representing child labor in 1920. Investigators asked the students to identify and deﬁne the problem in the photo. They were also asked to explore ways to deal with it. A rating system called the Critical Thinking Rubric was used to evaluate the results. Those who participated in National History Day demonstrated a deeper ability to explore the problem of child labor than those who didn’t participate. For Lu, the end result is satisfaction. “I enjoy applying my own research methods and making use of them,” he said. ■

Advancing Knowledge. Improving Life.

effect don’t work for this kind of observational study. “Lu helped make sure we were correctly matching the treatment and control students in order to isolate participation in National History Day as the only variable,” Wood said. Lu used a technique called propensity score matching to further sort the two groups based on gender, ethnicity, need for social service beneﬁts and reading scores taken from an eighth-grade achievement test. “Propensity score matching is a popular and effective method of analyzing observational data,” Lu said. Based on the closeness of the propensity score, students in both groups were matched together to form a pair using an optimal matching algorithm. The matching produced 24 participant-control pairs, in which the observed baseline variables were well balanced in the two groups. “If one kid scores well in school, we want to match him with another kid who scores well,” Lu said. “If you don’t match the comparison groups evenly, the result is biased.” Investigators compared the two groups by their scores on the Ohio Graduation Test. Those who participated in National History Day in Ohio scored signiﬁcantly higher in writing, reading and social sciences, than those who didn’t participate. Investigators also measured students’ understanding and appreciation of history. Appreciation of history was evaluated through a questionnaire with open- and closed-ended questions, which explored feelings and attitude toward history and

2007 National History Day in College Park Maryland. The students in the photo qualiﬁed at Ohio’s State History Day to attend the national event.

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Faculty News

Mel Moeschberger

AAAS selects CPH faculty in latest class Two public health faculty members recently were chosen as fellows of the American Association for the Advancement of Science (AAAS), the world’s largest scientiﬁc organization. Mel Moeschberger, professor of statistics and professor emeritus, was selected for his distinguished contributions to biostatistics and applied statistics, including co-authorship of textbooks on statistical concepts and survival analysis that have become classics for applied researchers. David Murray, chair of the Division of Epidemiology and interim chair of the Division of Biostatistics, was honored for his distinguished contributions to the ﬁeld of epidemiology, particularly on the design and analysis of group-randomized trials for assessment and effective intervention. “This is continued evidence that the college is growing a world-class public health faculty,” said Dean Stanley Lemeshow. The College’s other AAAS fellows are: Lemeshow; Electra Paskett, professor in the Division of Epidemiology; and Mary Ellen Wewers, professor in the Division of Health Behavior and Health Promotion.

Fruits of Weghorst’s labor include additional funds Christopher M. Weghorst, associate professor in the Division of Environmental Health Sciences, received $1.4 million in funding from the National Cancer Institute for a 5year R01 study titled “Food-Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer.” The study, which takes place from December 2007 through November 2012, will examine the effectiveness of using foods rich in phytochemicals, such as lyophilized black raspberries, to inhibit the progression of cancer. “Black raspberries are a very complex mixture of chemical compounds,” said Weghorst, who described the fundamental 14

Mira Katz

Janet de Moor

ideas behind the novel clinical trial. “Black raspberries are rich in vitamins A, C, and E, folic acid, calcium and several antioxidants such as anthocyanins and ellagic acid. One or more of these compounds, or even some other bioactive component, could be responsible for the chemopreventive response we and others have observed with black raspberries in numerous animal models of cancer.” The goal of the study is to extend the evaluation of the chemopreventive potential of black raspberries to the problem of human oral cancer, including the effectiveness of administering them to post-surgical oral cancer patients to prevent cancer recurrence.

Two professors receive grants from Population and Health initiative Two faculty members from the College of Public Health were among the recipients of two-year grants from The Ohio State University’s Population and Health research initiative. CPH’s Mira Katz and Janet de Moor received the funding. The initiative is an interdisciplinary research effort spearheaded by Ohio State’s College of Social and Behavioral Sciences (SBS). Other colleges involved include Public Health, Nursing, and Education and Human Ecology. Katz, assistant professor in the Division of Health Behavior and Health Promotion, and two collaborators in SBS, were awarded funding for “Development of a Communitybased Intervention to Improve Acceptance of the Human Papillomavirus Vaccine in Appalachia.” De Moor, assistant professor in the Division of Health Behavior and Health Promotion, along with three other Ohio State collaborators was awarded funding for “Panel Study of Asian Americans.” “The purpose of our project is to collect pilot data that will support a larger grant to conduct a nationally representative panel study of Asian Americans,” de Moor said.

Advancing Knowledge. Improving Life.

Randi Love

David Murray

Love helps conquer conflict in schools, prisons Working for a local nonprofit organization, has been a real win-win situation for Randi Love, clinical associate professor in the Division of Health Behavior and Health Promotion. For 10 years, she’s channeled her expertise into WinWin, a Columbus-based organization that provides conflict management skills to school-age youth and incarcerated adults. Love helped design the curriculum for WinWin’s five educational programs, three of which are currently recognized as “Best Practice” methods by the Ohio Department of Rehabilitation and Correction for prisoners who are reentering society. “She is a critical factor in WinWin’s research-based excellence,” said Lauren McGarity, executive director of WinWin. “Her insight to the needs of families and children of the incarcerated contributes a rich context to our curricula development.” In schools, WinWin’s strategies allow students to settle their own disputes rather than depend on overtaxed teachers to act as mediators. In prisons, conflict management skills are taught to prisoners to use for situations inside and outside of prison. WinWin receives funding from state and federal sources. “It makes sense to give them the skills to deal with conflict,” Love said. “The most important theme to the organization’s work is that kids and adults work in a safe environment to resolve conflict where it’s not escalated or ignored, but where it is used in a learning context. Therefore, people learn to resolve conflict non-violently while increasing critical thinking and communication skills.” In January, organizers of WinWin held a fundraising event in Ohio Stadium to raise awareness and involvement, especially among college students. It included live music, hot-air-balloon rides and a silent auction containing artwork created and donated by previously incarcerated men. The

Phyllis Pirie

Kenneth Steinman

items generated $400 for the WinWin program. “I am particularly interested in providing opportunities for students to work with WinWin in the prison setting,” Love said. “Most incarcerated persons will eventually be returning to their families and communities, which has signiﬁcant public health implications.”

Murray serves NHLBI on strategic plan group David Murray, professor and chair of the Division of Epidemiology and interim chair of the Division of Biostatistics, was one of two OSU representatives called on to help the National Heart Lung and Blood Institute write its strategic plan. The association provides information to researchers, health professionals and patients about diseases of the lungs, heart and blood vessels. The recently released strategic plan, titled “Shaping the Future of Research,” will guide the association’s scientiﬁc directions for the next ﬁve to 10 years. More than 600 researchers from around the United States contributed to the completion of the 54-page document.

Netwellness.org receives funding NetWellness.org, a nonproﬁt consumer health Web site operated by the College of Public Health and two other Ohio universities, was awarded $421,000 from the State Library of Ohio and Ohio Public Library Information Network. The funds will help sustain the $600,000 operational budget of NetWellness.org, an advertisement-free, consumer health Web site produced by OSU, Case Western Reserve University and the University of Cincinnati. “It represents recognition by Ohio libraries that NetWellness provides a signiﬁcant service to Ohioans,” said Phyllis Pirie, director of the Ohio State NetWellness program and professor of health behavior and health promotion. Launched in 1995, NetWellness is a Web-based consumer 15

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Faculty News

health and education resource created in response to the public’s growing desire for accessible information via the Internet about health and medicine. The site contains 53,000 pages of health information, including current health news, a health encyclopedia and an “Ask an Expert” feature that allows users to question medical professionals from the three universities. Currently 515 faculty members participate, 226 of whom are from OSU and include dentists, nurses, athletic trainers and social workers. Besides donating their time to respond to the public’s questions, faculty members also write articles on many health-related topics in an effort to create a comprehensive database. NetWellness also is funded through various state and federal grants, and some corporate sponsorships. The site can be accessed at www.netwellness.org.

Wilkins heads effort to reduce agricultural injuries Injury among youths in the agricultural industry is a serious problem, says J.R. Wilkins III, College of Public Health epidemiology professor. That’s why he and fellow epidemiology professor David M. Murray have teamed with Stanford University to determine ways to lower the risks that children face and decrease the number of injuries. “Despite attempts to reduce the impact of the number of childhood agricultural injuries over the past 15 years,” Wilkins said, “rigorous evaluations in this area are sorely lacking.” The study, titled “Developing and Evaluating New Approaches to Youth Agricultural Injury Prevention,” began in September 2007, and will continue through August 2010. Funded by the National Institute for Occupational Safety and Health, the study involves researchers from Ohio, California, Wisconsin, Colorado and Alabama, who will focus on educating families whose children work in the agricultural industry. Families will be given educational materials, which will be expanded versions of a 1999 publication called the “North American Guidelines for Children’s Agricultural Tasks.” “The underlying rationale here is that a family16

based approach can stimulate a synergistic family dynamic resulting in maximal compliance of all adults and youth in the household,” Wilkins said.

Steinman teams with institute to address family violence in Ohio Kenneth Steinman, assistant professor in the Division of Health Behavior and Health Promotion, has teamed with the Health Policy Institute of Ohio to fight family violence in Ohio. “Few political and community leaders recognize the enormous harm that family violence causes in Ohio or the promising, yet isolated, prevention efforts across the state,” said Steinman, who’s leading the Ohio Family Violence Prevention Project, which began in January 2007 with support from the Anthem Foundation of Ohio. In that same year, more than 64,000 children were abused or neglected; 166,000 people were assaulted by an intimate partner; and 29,000 elders were abused or neglected in Ohio, according to Steinman’s research. Family violence doesn’t just harm its victims, he says, it costs Ohio more than $1.1 billion annually in direct expenditures for health care and social services. In February, Steinman and the Health Policy Institute of Ohio organized a statewide conference to debut their “White Paper on Improving Family Violence Prevention in Ohio.” The conference featured prominent speakers including state Sen. Ray Miller (D-Columbus), state Rep. Jon Peterson (R-Delaware) and Jim Mercy, associate director of science for the National Center for Injury Control and Prevention. Also attending were members of the Project Working Group, including practitioners, researchers and representatives from the Ohio Department of Aging, Ohio Attorney General’s Office, Ohio Department of Health and the Ohio Domestic Violence Network. The White Paper presents a broad vision and specific recommendations for how to improve family violence prevention in Ohio. ■

CPH Master of Health Administration students (from left) Nick Schmidt, Kyle Dorsey and Julie Anstine receive a celebratory $9,000 check from Ray Watts for their ﬁrst-place ﬁnish in the national Case Competition on Feb. 7 in Birmingham, AL. Watts is the CEO of UAB Health System, which sponsored the competition.

College creates research program for undergrads Six CPH faculty members successfully competed for college funds to appoint gifted undergraduate students to participate in research projects. The faculty are: Ann McAlearney, Sharon Schweikhart, Michele Shipp, Amy Ferketich, Judy Schwartzbaum and Qinghua Sun. “I had an overwhelming response to an ad we placed on the “Honors and Scholars” Web site,” said Ann McAlearney, associate professor in the Division of Health Services Management and Policy. “More than 40 undergrads applied, including one from overseas.” McAlearney selected two students, one of whom will be paid through college funds. Viral Patel will participate in a study titled “Executive Leadership Development Initiatives in Health Care Organizations,” and Abhi Kasinadhuni will work on a study about the use handheld electronic devices in clinical care. The projects will last three quarters. Qinghua Sun, assistant professor in the Division Matt Verdin of Environmental Health Sciences, received more than 150 applicants for his proposed project on how exposure to air pollution may increase a child’s chance of developing diabetes in adulthood. Sun chose Matt Verdin, a freshman who’s majoring in philosophy and hopes to one day become a medical doctor. “I am very proud of him,” Sun said of Verdin. “He’s been working hard to generate enough data to present an abstract at the Denman Undergraduate Research Forum in May at the RPAC.” Verdin will work for Sun through October. Amy Ferketich, assistant professor in the Division of Epidemiology, selected Ramez Khalaf to participate in a study

Advancing Knowledge. Improving Life.

Student News

that examines the current trend of hookah cafes in Ohio. A hookah café is an establishment where patrons share ﬂavored tobacco from a communal water pipe. Ferketich says even though Ohio passed a smoke-free law in 2006, the cafes are exempt because owners claim they’re retail shops. “Hookah cafes may be particularly attractive to college students,” Ferketich said. “They serve as possible substitutions for bars for those under 21 who don’t drink alcohol.” The project is for winter and spring quarter. Other projects include Schwartzbaum’s study on identifying immune-related genetic pathways that affect glioma risk and survival, Schweikhart’s study on the use of computers while treating patients, and Shipp’s study on the needs of East African immigrants in Franklin County.

Epidemiology PhD student earns Trustees’ recognition award Ross Kauffman, a College of Public Health student pursuing a doctorate in epidemiology and a minor in criminology, was presented the Student Recognition Award by the Ohio State Board of Trustees on Sept. 21, 2007. The award is presented each month to a student in honor of his or her academic accomplishments, service to the community and research achievements. Kauffman served as a research assistant, examining cancer cases among the Amish population and its surrounding communities. For his next assignment, Kauffman plans to study the health of prisoners who use tobacco or are exposed to secondhand smoke. Kauffman’s advisor is Assistant Professor Amy Ferketich in the Division of Epidemiology.

Health policy research paper honored by national group Ellen Yard, a PhD student in the Division of Epidemiology, is the recipient of the 2007 Best Ohio Health Policy Student Research Award for her paper titled “An Epidemiologic Comparison of Injuries Presenting to a Pediatric Emergency 17

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Department and Local Urgent Care Facilities.” The award was given by the American Public Health Association and the Injury Control and Emergency Health Services Section. “This (award) reﬂects the great education and support I received from the Ohio State University College of Public Health,” said Yard, who received her Masters of Public Health degree in epidemiology in 2006. In her paper, Yard discusses the risk factors responsible for severe injuries in high-school football. She says the severity of injury depends upon various factors, including phases of play, ﬁeld location and time of play. Yard’s CPH advisor is Randall Harris, professor of epidemiology, and her mentor for the project was Dawn Comstock, PhD, assistant professor of pediatrics in the College of Medicine.

Two health behavior students awarded research funding CPH students Sarah Heaner and Megan Knapke, two students in the Division of Health Behavior and Health Promotion, were awarded research funding from OSU’s Critical Difference for Women program. Assistant Professor Mira Katz is the faculty advisor for both Heaner and Knapke. The OSU Critical Difference for Women, founded in 1986, is a program that offers scholarships and grants to female students, faculty and staff who are seeking advanced education and enhanced professional lives. The research awards will be used toward conducting Heaner’s study “Health-related lifestyle changes among young breast cancer survivors” and Knapke’s study “Youth empowerment strategies (YES!): enhancing learning and assessing health needs.”

Studnek’s epidemiology research featured in ‘New York Times’ Jonathan R. Studnek, a PhD candidate in the Division of Epidemiology, was featured in an article in The New York Times on Jan. 15. The article, “Hazards: Needing the First Aid They Give to Others,” said a College of Public Health study ﬁnds that ambulance workers face a high risk of getting hurt on the job, resulting in them taking time off of work due to injury. Most injuries are caused by lifting patients. “You’ve got to move people not just from the sidewalk to the ambulance

but up and down ﬂights of stairs,” Studnek told a Times reporter. The study that the article is based on stems from research by Studnek and John Crawford, assistant professor in the Division of Environmental Health Sciences. Studnek’s academic advisor is Amy Ferketich, assistant professor in the Division of Epidemiology.

Environmental health student takes top prize for toxicology talk Blake Warner, a PhD student in the Division of Environmental Health Sciences, won first place in a competition sponsored by the Ohio Valley Chapter Society of Toxicology, where he described his research in an oral presentation titled “Chemoprevention of DMBA-Induced HCP Carcinogenesis by Lyophilized Strawberries.” Warner was one of four students selected to give a 15minute oral presentation about their toxicology research. “This research demonstrated that strawberries in the diet of hamsters can prevent the formation of carcinogen-induced oral cancer,” Warner said. “The research demonstrated, for the first time, that strawberries can regulate genes in the hamster which are disregulated in human oral cancer.” As a result of winning first place in the competition, Warner not only received $500, but also became a student representative of the national society of toxicology and will get to travel expense-free to the 2008 Annual Society of Toxicology Meeting. Warner’s academic advisor is Christopher Weghorst, associate professor in the Division of Environmental Health Sciences.

CPH alumni present at APHA Two College of Public Health alumni presented seminars at the 2007 American Public Health Association’s Annual Meeting in Washington, D.C. Sato Ashida, PhD, talked about the change in family relationships after genetic counseling. Ashida is currently a Postdoctoral Fellow at the National Human Genome Research Institute in Bethesda, Md. Yosef Khan, MD, MPH, assistant clinical research manager in Ohio State’s Department of Infectious Diseases, presented “Examination of a cross sectional association between intake levels of the antioxidant vitamins E, C, and B6 and diabetic peripheral neuropathy.” ■

Jonathan Studnek’s research on injury risks faced by ambulance workers was featured in a New York Times article.

Winners of the College of Public Health’s 2007 Champions of Public Health Awards, from left: Larry Hill, DDS; Robert Murray, MD; Kim Toole, RN; Anne Harnish; Noble Maseru, MD. Visit cph.osu.edu for more information.

Advancing Knowledge. Improving Life.

Public health champions celebrated

2008 Champions of Public Health Awards

Nomination Form Sponsored by The Ohio State University College of Public Health We invite you to identify and nominate worthy individuals who, through their professional achievements, volunteer service or civic involvement, personify the mission of the College of Public Health to advance knowledge and improve lives. • Nominees must be an individual or organization who has made a signiﬁcant contribution to the health of Ohioans. • Individuals may be nominated posthumously, but the committee prefers nominees who are living at the time of nomination. • For the community leader category, the college encourages nominations of volunteers as well as public health professionals. • Individuals may come from all ﬁelds of public health. • Submit this nomination form and a one-page nominating statement. I nominate

Please attach your nomination to this form and mail to: Champions of Public Health Awards Committee OSU College of Public Health M101 Starling Loving Hall 320 W. 10th Ave. Columbus OH 43210 All nominations packets must be postmarked no later than June 15. Additional forms are available by emailing comalley@cph.osu.edu.

(full name)

for the Champions of Public Health Award in the category Nominee

• You may include up to two letters of support. Letters of support are limited to one 8 ½” x 11” page each, singlespaced.

(community leader, public health practitioner, or organization)

street address city/state/zip phone number Nominator your name street address city/state/zip phone number email address 19

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2007 Publications Fann, J.R., Alfano, C.M., Roth-Roemer, S., Katon, W.J., Syrjala, K.L. Delirium in patients undergoing hematopoietic stem cell transplantation: Impact on cognition, distress and health-related quality of life. Journal of Clinical Oncology. 25: 2007. 1223-1231. Bowen, D.J., Alfano, C.M., McGregor, B.A., Kuniyuki, A., Bernstein, L., Meeske, K., Baumgartner, K.B., Fetherolf, J., Reeve, B., Smith, A. W., Malone, K., McTiernan, A., Ballard-Barbash, R. Possible socioeconomic and ethnic disparities in quality of life in a cohort of breast cancer survivors. Breast Cancer Research & Treatment. 106(1): 2007. 85-95. Meeske, K., Smith, A.W., Alfano, C.M., McGregor, B.A., McTiernan, A., Baumgartner, K.B., Malone, K., Reeve, B., Ballard-Barbash, R., Bernstein, L. Fatigue in Breast Cancer Survivors Two to Five Years Post Diagnosis: A HEAL Study Report. Quality of Life Research. 16(6): 2007. 947-960. Anderson SE, Cohen P, Naumova EN, Jacques P, Must A. Adolescent overweight and risk for subsequent major depressive disorder and anxiety disorder: prospective evidence. Psychosomatic Medicine. 69: 2007. 740-747. Arkes, H.R., Shaffer, V.A., Medow, M.A. Patients derogate physicians who use a computer-assisted diagnostic aid. Medical Decision Making. 27: 2007. 189-202. Arkes, H.R. A guide to good judgment and decision making. [Review of the book Don’t Believe Everything You Think]. PsycCRITIQUES — Contemporary Psychology: APA Review of Books. 52(3): 2007. Conde JF, Yelverton CB, Balkrishnan R, Fleischer AB Jr, Feldman SR. Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. Journal of Drugs in Dermatology. 6(5): 2007. 495-498.

Garduno J, Bhosle MJ, Balkrishnan R, Feldman SR. Measures Used in Specifying Psoriasis Lesion(s), Global Disease & Quality of Life: A Systematic Review. Journal of Dermatological Treatment. 18(4): 2007. 223-242. Pawaskar MD, Anderson RT, Balkrishnan R. SelfReported Predictors of Depressive Symptomatology in an Elderly Population with Type 2 Diabetes Mellitus: A Prospective Cohort Study. Health and Quality of Life Outcomes. 5(1): 2007. 50 (6 printed pages, online publication). Pawaskar MD, Satiani B, Balkrishnan R, Starr JE. Economic Evaluation of Carotid Angioplasty and Stenting versus Carotid Endarterectomy for the Treatment of Carotid Artery Stenosis: A Provider’s Perspective. Journal of the American College of Surgeons. 205(3): 2007. 413419. Jayawant SS, Bhosle MJ, Anderson RT, Balkrishnan R. Depressive symptomatology, medication persistence, and associated health care costs in older adults with glaucoma. Journal of Glaucoma. 16(6): 2007. 513-520. Rasu RS, Crawford T, Manley HJ, Balkrishnan R. Treatment of hypertension and diabetes mellitus in patients with chronic kidney disease: a review. Expert Opinion on Pharmacotherapy. 8(15): 2007. 2543-2551. Jayawant SS, Camacho FT, Anderson RT, Balkrishnan R. Does the use of Thiozolidinediones in older adults with Type 2 diabetes Improve Outcomes? A Database Analysis. Drug Beneﬁt Trends. 19(Supplement B): 2007. 22-32.

Feldman SR, Camacho FT, Krejci-Manwaring J, Carroll CL, Balkrishnan R. Adherence to topical therapy increases around the time of ofﬁce visits. Journal of the American Academy of Dermatology. 57(1): 2007. 81-83.

Fosse K, Kurtz E, Khanna V, Camcho F, Balkrishnan R, Feldman SR. A practice brochure is a complement to, not a supplement for, a good physician-patient interaction. (Research Letter). Archives of Dermatology. 143(11): 2007. 1447.

McMichael AJ, Wasserman DI, Pearce DJ, Camacho FT, Fleischer AB, Feldman SR, Balkrishnan R. Alopecia Areata: Outpatient Utilization and Common Prescribing Patterns in the United States. Journal of the American

Kong MC, Camacho FT, Feldman SR, Anderson RT, Balkrishnan R. Correlates of patient satisfaction with physician visits: Differences between elderly and non-elderly survey respondents. Health and Quality of

Academy of Dermatology. 57(2): 2007. s49-s51.

Life Outcomes. 5(1): 2007. 62 (6 printed pages, online publication).

Rasu RS, Manley H, Crawford T, Balkrishnan R. Undertreatment of Anemia in patients with Chronic Kidney Disease in the United States: Analysis of the U.S. National Ambulatory Medical Care Survey. Clinical Therapeutics. 29(7): 2007. 1524-1534. Ali SM, Brodell RT, Balkrishnan R, Feldman SR. Poor Adherence to Treatments: A Fundamental Principle of Dermatology. Archives of Dermatology. 143(7): 2007. 912-915.

Stojanokvski S, Rasu RS, Nahata MC, Balkrishnan R. Trends in Medication Prescribing For Children with Sleep Disorders in US Outpatient Settings. Sleep. 30(8): 2007. 1013-1017.

Awadalla FC, Yentzer B, Balkrishnan R, Feldman SR.A role for denial in poor adherence to psoriasis treatment. Journal of Dermatological Treatment. 18(6): 2007. 324325. Kim SR, Halden RU, Buckley TJ. Volatile organic compounds in human milk: methods and measurements. Environmental Science and Technology. 41(5): 2007. 1662-1667.

Rule AM, Kesavan J, Schwab KJ, Buckley TJ. Application of flow cytometry for the assessment of preservation and recovery efficiency of bioaerosol samplers spiked with pantoea agglomerans. Environmental Science and Technology. 41:2007. 2467-2472. Kim SR, Dominici F, Buckley TJ. Concentrations of vehicle-related air pollutants in an urban parking garage. Environmental Research. 105(3): 2007. 291-299. Geer LA, Anna DH, Curbow BA, Diener-West M, Mitchell C, van-Wendel-de-Joode B, Buckley TJ. Survey assessment of worker dermal exposure and underlying behavioral determinants. Journal of Occupational & Environmental Hygiene. 4(11): 2007. 809-820. Fan VS, Savage RE, Buckley, TJ. Methods and measurements for estimating human dermal uptake of volatile organic compounds (VOC’S) and for deriving dermal permeability coefficients (KP). Toxicology Mechanisms and Methods. 17: 2007. 295-304 (IF=0.411) Harpe SE, Szeinbach SL, Caswell RJ, Corey R, McAuley JW. The relative importance of health related quality of life and prescription insurance coverage in the decision to pharmacologically manage symptoms of overactive bladder. Journal of Urology. 178:2007. 2532-2536. Studnek J, Crawford JM. Factors Associated With Back Problems among Emergency Medical Technicians. American Journal of Industrial Medicine. 50:2007. 464-469. Studnek J, Ferketich A, Crawford JM. On the Job Illness and Injury Resulting in Lost Work Time Among a National Cohort of Emergency Medical Services Professionals. American Journal of Industrial Medicine. 50:2007. 921-931. Dembe AE, Delbos R, Erickson JB, Banks SM. Associations between employees’ work schedules and the vocational consequences of workplace injuries. Journal of Occupational Rehabilitation. 17(4): 2007. 641-651. de Moor, J.S., Puleo, E., Butterfield, R.M., Li, F.P., Emmons, K.M. Availability of smoking prevention and cessation services for childhood cancer survivors. Cancer Causes and Control. 18(4):2007. 423-430. Wu G, Yang W, Barth RF, Kawabata S, Swindall M, Bandyopadhyaya AK, Tjarks W, Khorsandi B, Blue TE, Ferketich AK, Yang M, Christoforidis GA, Sferra TJ, Binns PJ, Riley KJ, Ciesielski MJ, Fenstermaker RA. Molecular targeting and treatment of an epidermal growth factor receptor-positive glioma using boronated Cetuximab. Clinical Cancer Research. 13:2007. 12601268. Iyengar S, Haas G, Lamba S, Orsinelli DA, Babu GJ, Ferketich AK, Yamokoski L, Periasamy M, Abraham WT. Effect of cardiac resynchronization therapy on myocardial gene expression in patients with nonischemic dilated cardiomyopathy. Journal of Cardiac Failure. 13:2007. 304-311.

Duncan FJ, Wulff BC, Tober KL, Ferketich AK, Martin J, Thoman-Ahner JM, Allen SD, Kusewitt DF, Oberyszyn TM, VanBuskirk AM. Clinically relevant immunosuppressants influence UVB-induced tumor size through effects on inflammation and angiogenesis. American Journal of Transplantation. 7:2007. 2693-2703. Lord LK, Wittum TE, Ferketich AK, Funk JA, RajalaSchultz PJ. Search and identification methods that owners use to find a lost cat. Journal of the American Veterinary Medical Association. 230:2007. 217-220. Lord LK, Wittum TE, Ferketich AK, Funk JA, RajalaSchultz PJ. Search and identification methods that owners use to find a lost dog. Journal of the American Veterinary Medical Association. 230:2007. 211-216. Ferketich AK, Wee AG, Shultz J, Wewers ME. A measure of nicotine dependence for smokeless tobacco users. Addictive Behaviors. 32:2007. 1970-1975. Ferketich AK, Kwong K, Shek A, Lee M. Design and evaluation of a tobacco-prevention program targeting Chinese American youth in New York City. Nicotine & Tobacco Research. 9:2007. 249-256. Studnek JR, Ferketich AK. Organizational policy and other factors associated with emergency medical technician seat belt use. Journal of Safety Research. 38:2007. 1-8. Clark BR, Ferketich AK, Fisher J, Ruymann FB, Harris RE, Wilkins JR III. Evidence of population mixing based on the geographical distribution of childhood leukemia in Ohio. Pediatric Blood and Cancer. 49:2007. 797-802. Harwood GA, Salsberry P, Ferketich AK, Wewers ME. Cigarette smoking, socioeconomic status, and psychosocial factors: Examining a conceptual framework. Public Health Nursing. 24:2007. 361-371. Lord LK, Wittum TE, Ferketich AK, Funk JA, RajalaSchultz PJ. Search methods that people use to find owners of lost pets. Journal of the American Veterinary Medical Association. 230:2007. 1835-1840. Ferketich AK, Wee AG, Shultz J, Wewers ME. Smokeless tobacco use and salivary cotinine concentration. Addictive Behaviors. 32:2007. 2953-2962. Dirksen W.P., Nadella K.S, Shu S., Cheng A.S., Morgenstern J.A.,Richard V., Fernandez S.A., Huang T.H., Guttridge D., Rosol T.J. Transcriptional Regulation of Parathyroid Hormone-Related Protein Promoter P2 by NFkappaB in Adult T-cell Leukemia/Lymphoma. Leukemia. 21(8): 2007. 1752-1762. Shu S.T., Nadella M.V., Dirksen W.P., Fernandez S.A., Thudi N.K., Werbeck J.L., Lairmore M.D., Rosol T.J. A novel bioluminescent mouse model and effective therapy

for adult T-cell leukemia/lymphoma. Cancer Research. 67(24): 2007. 11859-11866. Opavsky R. Tsai S-Y., Guimond M., Arora A., Opavska J., Becknell B., Kaufmann M., Walton N., Stephens J.A., Fernandez S.A., Muthusamy N., Felsher D.W., Pierluigi, P., Caligiuri M.A., Leone G. Specific Tumor Suppressor Function for E2F2 in Myc-induced T cell Lymphomagenesis. The Proceedings of the National Academy of Sciences. 104(39): 2007. 15400-15405. Jadcherla S.R., Gupta A., Coley B.D., Fernandez S., Shaker R. Esophago-Glottal closure reflex in human infants: a novel reflex elicited with concurrent manometry and ultrasonography. American Journal of Gastroenterology. 102(10): 2007. 2286-2293. Jadcherla S.R., Gupta A., Stoner E., Fernandez S., Shaker R. Pharyngeal Swallowing: Defining Pharyngeal and Upper Esophageal Spinchter Relationships in Human Neonates. The Journal of Pediatrics. 151(6): 2007. 597-603. Stoner M.J., Goodman D.G., Cohen D.M., Fernandez S.A., Hall M.W. Rapid Fluid Resuscitation in Pediatrics: Testing the American College of Critical Care Medicine Guideline. Annals of Emergency Medicine. 50(5): 2007. 601-607. Hall M.W., Gavrilin M.A., Knatz N.L., Duncan M.D., Fernandez S.A., Wewers M.D. Monocyte mRNA Phenotype and Adverse Outcomes From Pediatric Multiple Organ Dysfunction Syndrome. Pediatric Research. 62(5): 2007. 597-603. Licht B.G., Lin S., Luo Y., Hyson L.L., Licht M.H., Harper K.M., Sullivan S.A., Fernandez S.A., Johnston E.V. Familial Focal Seizures in Standard Poodles: Clinical Characteristics andMode of Inheritance. Journal of the American Veterinary Medical Association. 231(10): 2007. 1520-1528. Shields B.J., Comstock R.D., Fernandez S.A., Xiang H., Smith G.A. Healthcare resource utilization and epidemiology of Pediatric Burn-Associated Hospitalizations, United States, 2000. Journal of Burn Care and Research. 28(6): 2007. 811-826. Gardner R., Smith G.A., Chany A.M., Fernandez S.A., McKenzie L.B. Factors Associated with Hospital Length of Stay and Hospital Charges of Motor Vehicle CrashRelated Hospitalizations Among Children in the United States. Archives of Pediatrics & Adolescent Medicine. 161(9): 2007. 889-895. Craigmile P.F., Kim N., Fernandez S.A., Bonsu B.K. Modeling and detection of respiratory-related outbreak signatures. BMC Medical Informatics and Decision Making. 7: 2007. 28. Bolinger C., Hartman T.R.,Yilmaz A., Kovacic M.B., Fernandez S.A., Forget M., Green P.L., Boris-Lawrie K. RNA helicase A is necessary for HTLV-1 replication and interacts with the 5’ UTR of divergent lymphotropic retroviruses to facilitate Gag production. Nucleics Acids Research. 2007. 1-14.

Meta I.F., Fernandez S.A., Gulati P., Huja S.S. Adaptations in the mandible and appendicular skeleton of high and low bone density inbred mice. Calciﬁed Tissue International. 81(2): 2007. 107-113. Deitchler M., Valadez J.J., Egge K., Fernandez S., Hennigan M.A. Field Test of Three LQAS Designs to Assess the Prevalence of Acute Malnutrition. International Journal of Epidemiology. 36(4): 2007. 858-864. Sasser A.K., Mundy B.L., Smith K.M, Studebaker A.W., Axel A.E., Haidet A.M., Fernandez S.A., Hall B.M. Human Bone Marrow Stromal Cells Enhance Breast Cancer Cell Growth Rates in a Cell Line-Dependent Manner when Evaluated in 3D Tumor Environments. Cancer Letters. 254(2): 2007. 255-264.

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Trotta R, Ciarlariello D, Dal Col J, Allard II J, Neviani P, Santhanam R, Mao H, Becknell B, Yu J, Ferketich AK, Thomas B, Modi A, Blaser BW, Perrotti D, and Caligiuri MA. The PP2A inhibitor SET regulates natural killer cell IFN-? production. Journal of Experimental Medicine. 204:2007. 2397-2405.

Woodley F., Fernandez S.A., Mousa H. Diurnal variation in the chemicalclearance of acid gastroesophageal reflux. Clinical Gastroenterology and Hepatology. 5(1):2007. 37-43. Boreman C.D., Thomasgard M., Fernandez S.A., Coury D.L. Resident Trainingin Developmental and Behavioral Pediatrics. Where Do We Stand? ClinicalPediatrics. 46(2):2007. 135-145. Huja S.S., Fernandez S.A., Hill K.J., Gulati P. Indentation Modulus of the Alveolar Process in Dogs. Journal of Dental Research. 86:2007. 237-241. Focht, B.C. Perceived exertion during self-selected and imposed-intensity bouts of resistance exercise in untrained women. Journal of Strength and Conditioning Research. 21:2007. 183-187. Focht, B.C. Obesity and knee osteoarthritis: Behavioral considerations in weight management. International Journal of Advances in Rheumatology. 4:2007. 128-132. Focht, B.C., Knapp, D.J., Raedeke, T.D., Gavin, T.P., and Hickner, R.C. Affective and self-efficacy responses to acute aerobic exercise in sedentary older and younger adults. Journal of Aging and Physical Activity. 15:2007. 123-138. Raedeke, T., Focht, B.C., Scales, D. Social environmental factors and psychological responses to acute exercise for socially physique anxious females. Psychology of Sport and Exercise. 8:2007. 463-476. Focht, B.C., Hausenblas, H.A. Exercising in public and private environments: Effects on feeling states in women with social physique anxiety. Journal of Applied Biobehavioral Research. 11:2007. 147-165. Harris RE, Beebe-Donk JD, Alshafie GA. Cancer chemoprevention by selective cyclooxygenase-2 (COX-2) blockade: results of case control studies. Subcellular Biochemistry. 42: 2007. 83-126. Harris RE. COX-2 and the inflammogenesis of cancer. Subcellular Biochemistry. 42:2007. 193-212.

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Harris RE, Beebe-Donk J, Alshaﬁe GA. Reduced risk of human lung cancer by selective cyclooxygenase-2 (COX2) blockade: results of a case control study. International Journal of Biological Sciences. 3(5):2007. 328-334.

Rosner B, Glynn RJ, Lee M-LT. A Nonparametric Test for Observational Non-Normally Distributed Ophthalmic Data with Eye-Speciﬁc Exposures and Outcomes. Ophthalmic Epidemiology. 14:2007. 243-250.

Sun, J., Tong, X., He, X. Regression analysis of panel count data with dependent observation times. Biometrics. 63:2007. 1053-1059.

Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee M-LT, Xiao T, Papp A, Wang D, Sadée W. Novel polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proceedings of the National Academy of Sciences, USA. 104:2007. 2055220557.

He, X., Tong, X., Sun, J. and Cook, R. Regression analysis of multivariate panel count data. Biostatistics. July 11, 2007 (online). He, X., Chen, L., Lei, L., Xia, H.A. Exposure adjusted incidence and event rates in safety analysis. Amgen Global Biostatistics and Epidemiology Technical Report. 1:2007. 20-35. Becknell, B., Hughes, T.L., Freud, A.G., Blaser, B.W., Yu, J. Trotta, R., Mao, H.C., Caligiuri de Jesús, M.L., Alghothani, M., Benson Jr., D.M., Lehman, A., Jarjoura, D., Perrotti, D., Bates, M.D., Caligiuri, M.A. The H1x homeobox transcription factor negatively regulates interferongamma production in monokine-activated natural killer cells. Blood. 109(6):2007. 2481-2487. Parsons, J.P., Kaeding, C., Phillips, G., Jarjoura, D., Wadley, G., Mastronarde, J.G. Prevalence of exerciseinduced bronchospasm in a cohort of varsity college athletes. Medicine and Science in Sports & Exercise. 39(9): 2007. 1487-1492. Yu, J., Wei, M., Boyd, Z., Lehmann, E.B., Trotta, R., Mao, H., Liu, S., Becknell, B., Jaung, M.S., Jarjoura, D., Marcucci, G., Wu, L.C., Caligiuri, M.A. Transcriptional control of human T-BET expression: The role of Sp1. European Journal of Immunology. 37(9): 2007. 2549-2561. Zhao X, Lapalombella R, Joshi T, Cheney C, Gowda A, Hayden-Ledbetter MS, Baum PR, Lin TS, Jarjoura, D., Lehman A, Kussewitt D, Lee RJ, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC. Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Blood. 110(7): 2007. 2569-2577. Katz ML, Wewers ME, Single N, Paskett ED. Key informants’ perspectives prior to beginning a cervical cancer study in Ohio Appalachia. Qualitative Health Research. 17(1):2007. 131-141. Katz, M.L., Tatum, C., Dickinson, S.L., Murray, D.M., Long-Foley, K., Cooper, M.R., Daven, M., Paskett, E.D. Improving colorectal screening by using community volunteers: results of the Carolinas Center Education and Screening (CARES) project. Cancer. 110(7):2007. 1602-1610. Katz ML, Tatum CM, DeGrafﬁnreid CR, Dickinson S, Paskett ED. Do cervical cancer screening rates increase in association with an intervention designed to increase mammography usage? Journal of Women’s Health. 16(1):2007. 24-35.

Lin, Y.C., Diccianni, M.B., Kim, Y., Lin, H. ., Lee, C. ., Lin, R. ., Joo, S.H., Li, J., Chuang, T.J., Yang, A.S., Kuo, H.H., Tsai, M.D., Yu, A.L. Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16 (INK4A) in cancer cells and inhibits cell-cycle progression. Oncogene. 26(49): 2007. 7017-7027. Eisenberg, J., Desai, M., Levy, K., Bates, S, Liang, S., Naumoff, K., Scott, J. Environmental determinants of infectious disease: A framework for tracking causal links and guiding public health research. Environmental Health Perspectives. 115(8): 2007. 1216-1223.

Ali NA, O’Brien JM Jr, Blum W, Byrd JC, Klisovic RB, Marcucci G, Phillips G, Marsh CB, Lemeshow S, Grever MR. Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality. Cancer. 110(1): 2007. 96-102.

Seto, E., Lee, E., Liang, S., Zhong, B. Individual and village-level study of water contact exposure patterns and Schistosoma japonicum infection in mountainous rural China. Tropical Medicine and International Health. 12(10): 2007. 1199-1209.

O’Brien JM Jr, Lu B, Ali NA, Martin GS, Aberegg SK, Marsh CB, Lemeshow S, Douglas IS. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Critical Care Medicine. 35(2): 2007. 345-350.

Liang, S., Seto, E., Remais, J., Zhong, B., Yang, C., Hubbard, A., Davis, G., Gu, X., Qiu, D., Spear, R.C. Environmental effects on parasitic disease transmission exempliﬁed by schistosomiasis in Western China. Proc Natl Acad Sci USA. 104 (17): 2007. 7110-7115.

Kiecolt-Glaser JK, Belury M, Porter K, Beversdorf D, Lemeshow S, Glaser R. Depressive Symptoms, omega6:omega-3 Fatty Acids, and Inﬂammation in Older Adults. Psychosomatic Medicine. 69(3): 2007. 217-224. Levine DA, Kiefe CI, Houston T, Allison JJ, McCarthy EP, Ayanian JZ. Younger stroke survivors have reduced access to physician care and medications. The National Health Interview Survey Years 1998 to 2002. Archives of Neurology. 64: 2007. 37-42. Colon-Emeric C, Lyles KW, Levine DA, House P, Schenk A, Gorospe J, Fermazin M, Oliver K, Allison J, Weisman N, Xie A, Curtis JR, Saag K. Prevalence and predictors of osteoporosis treatment in nursing home residents with known osteoporosis or recent fracture. Osteoporosis International. 18(4): 2007. 553-559. Levine DA, Kiefe CI, Howard G, Howard VJ, Williams OD, Allison JJ. Reduced medication access: a marker for vulnerability in US stroke survivors. The National Health Interview Survey from years 1997 to 2004. Stroke. 38(5): 2007. 1557-1564.

Moore, J.L., Elliott, J.O., Lu B. Prevalence of epilepsy and health status in Ohio based on the Behavioral Risk Factor Surveillance System, 2006. American Epilepsy Society meeting Philadelphia, PA. Epilepsia. 48(S6): 2007. 89-90. Ford, E.W., McAlearney, A.S., Phillips, M.T., Menachemi, N., Rudolph, B. Predicting Computerized Physician Order Entry System Adoption in U.S. Hospitals: Can the Federal Mandate be Met? International Journal of Medical Informatics. 2007 Nov 27; [Epub ahead of print] McAlearney, A.S., Reeves, K.W., Tatum, C., Paskett, E.D. Cost as a Barrier to Screening Mammography among Underserved Women. Ethnicity and Health. 12(2): 2007. 189-203. McAlearney, A.S., Chisolm, D.J., Schweikhart, S., Medow, M.A., Kelleher, K. The Story Behind the Story: Physician Skepticism About Relying on Clinical Information Technologies to Reduce Medical Errors. International Journal of Medical Informatics. 76(11-12): 2007. 836-842.

Houston TK, Funkhouser EM, Allison JJ, Levine DA, Williams OD, Kiefe CI. Multiple Measures of Provider Participation in Internet Delivered Interventions. Medinfo. 12 (Pt 2): 2007. 1401-1405.

Auseon, A.J., Tran T., Garcia, A.M., Hardy, C.J., Valavalkar, P., Moeschberger, M., Raman, S.V. Aortic Pathophysiology by Cardiovascular Magnetic Resonance in Patients with Clinical Suspicion of Coronary Artery Disease. Journal of Cardiovascular Magnetic Resonance. 9(1): 2007. 43-48.

Colón-Emeric C, Lyles KW, House P, Levine DA, Schenck A , Alison J, Gorospe J, Fermazin M, Oliver K, Curtis JR, Weisman W, Xie A, Saag K. Randomized trial to improve fracture prevention in nursing home residents. The American Journal of Medicine. 120(10): 2007. 886-892.

Jones, L.A., Sinnott, L., Mutti, D.O., Mitchell, G.L., Moeschberger, M.L., Zadnik, K. Parental history of myopia, sports and outdoor activities, and future myopia. Investigative Ophthalmology and Visual Science. 48(8): 2007. 3524-3532.

Safford MM, Halanych JH, Lewis CE, Levine D, Houser S, Howard G. Understanding racial disparities in hypertension control: Intensity of hypertension medication treatment in the REGARDS study. Ethnicity and Disease. 17(3): 2007. 421-426.

Murray, D.M., Blitstein, J.L., Hannan, P.J., Baker, W.L, Lytle, L.A. Sizing a trial to alter the trajectory of health behaviors: methods, parameter estimates, and their application. Statistics in Medicine. 26(11): 2007. 22972316.

Stevens, J., Taber, D.R., Murray, D.M., Ward, D.S. Advances and controversies in the design of obesity prevention trials. Obesity Research. 15(9): 2007. 2163-2170. Bhosle MJ, Vosuri V, Samuel SV, Paskett ED, Balkrishnan R. Physician and patient characteristics associated with outpatient breast cancer screening receommendations in the United States: Analysis of the National Ambulatory Medical Care Survey Data 1996-2004. Breast Cancer Research and Treatment. 103(1): 2007. 53-59. Kelly K, Dickinson S, Tatum C, DeGrafﬁnreid C, Paskett ED. Colorectal cancer screening in three racial groups. American Journal of Health Behavior. 31(5): 2007. 502-513. Paskett ED, Naughton MJ, McCoy TP, Case LD, Abbott JM. The epidemiology of arm and hand swelling in premenopausal breast cancer survivors. Cancer Epidemiology Biomarkers and Prevention. 16(4): 2007. 775-782. Lanza E, Yu B, Murphy G, Albert PS, Caan B, Marshall R, Lance P, Paskett ED, Weissfeld J, Slattery M, Burt R, Iber F, Shike M, Kikendall JW, Brewer B, Schatzkin A, The Polyp Prevention Trial Study Group. The Polyp Prevention Trial-Continued Follow-up Study: No effect of a low fat, high ﬁber, high fruit and vegetable diet on adenoma recurrence eight years after randomization. Cancer Epidemiology Biomarkers and Prevention. 16(9): 2007. 1745-1752.

Schwartzbaum J, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, Christensen HC, Henriksson R, Johansen C, Lindholm C, Malmer B, Salminen T, Schoemaker MJ, Swerdlow AJ, Feychting M. An international casecontrol study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiology, Biomarkers and Prevention. 16: 2007. 559-565. Wigertz A., Lönn S., Schwartzbaum JA, Hall, P, Auvinen A, Collatz-Christensen H, Johansen, C., Klaeboe, L., Salmine, T, Schoemaker, M., Swerdlow, A, Tynes, T. Feychting, M. Allergic conditions and brain tumor risk. American Journal of Epidemiology. 166: 2007. 941-950. Chiocca EA, Schwartzbaum JA. Gliomas and venous thromboembolism: how common? Journal of Neurosurgery. 106: 2007. 599-600. Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL.Epidemiology of Brain Tumors. Neurological Clinics. 25: 2007. 867-890. Schwartzbaum J, Ahlbom A, Feychting M. Cohort study of cancer risk among male and female shift workers. Scandinavian Journal of Work, Environment, and Health. 33(5): 2007. 336-343. Edwards CG, Schwartzbaum JA, Nise G, Forssén UM, Ahlbom A, Lönn S, Feychting M. Occupational Noise Exposure and Risk of Acoustic Neuroma. American Journal of Epidemiology. 166(11): 2007. 1252-1258.

Paskett ED, Reeves KW, Rohan TE, Allison MA, Williams CD, Messina CR, Whitlock E, Sato A, Hunt JR. Association Between Cigarette Smoking and Colorectal Cancer in the Women’s Health Initiative. Journal of the National Cancer Institute. 99(22): 2007. 1729-1735.

Schwartzbaum JA, Ahlbom A, Lönn S, Malmer B, Wigertz A, Auvinen A, Brookes AJ, Collatz Christensen H, Henriksson R, Johansen C, Salminen T, Schoemaker MJ, Swerdlow AJ, Debinski W, Feychting M. An international case-control study of interleukin-4Ralpha, interleukin-13 and cyclooxygenase-2 polymorphisms and glioblastoma risk. Cancer Epidemiology, Biomarkers and Prevention. 16(11): 2007. 2448-2454.

Pennell, M.L., Dunson, D.B. Fitting semiparametric random effects models to large data sets. Biostatistics. 8(4): 2007. 821-834.

Seiber EE. Physician Code Creep: Evidence in Medicaid and State Health Insurance Billing. Health Care Financing Review. 28(4): 2007. 83-94.

Daly, K.A., Pirie, P.L., Rhodes, K.L., Hunter, L.L., Davey,

Urofsky RI, Seiber EE, Hoffman NG. UNCOPE: Evaluation of a Brief Screen for Detecting Substance Dependence among Juvenile Justice Populations. Journal of School Counseling. v5(17): 2007 (online publication).

C.S. Early otitis media among Minnesota American Indians: The Little Ears study. American Journal of Public Health. 97(2): 2007. 317-322. Jordan, C.M., Lee, P.A., Olkon, R., Pirie, P.L. Messages from Moms: Barriers to and facilitators of behavior change in a lead poisoning prevention education project. Journal of Health Communications. 12: 2007. 771-786. Malmer BS, Feychting M, Lonn S, Lindstrom S, Gronberg H, Ahlbom A, Schwartzbaum J, Auvinen A, CollatzChristensen H, Johansen C, Kiuru A, Mudie N, Salminen T, Schoemaker MJ, Swerdlow AJ, Henriksson R. Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma. Journal of Neurooncology. 82: 2007. 229-237.

Seiber EE, Robinson AL. Microﬁnance Investments in Quality at Private Clinics in Uganda: A Case-Control Study. BMC Health Services Research. 7(1): 2007. 168. Seiber EE, Bertrand JT, Sullivan T. Changes in Contraceptive Method Mix in Developing Countries. International Family Planning Perspectives. v33(3):2007. 117-123. Song, PH, Smith DG. Financial Preconditions for Successful Community-Based Health Initiatives for the Uninsured. Journal of Healthcare Management. 52(6): 2007. 411-423.

Carlyle, K.A., Steinman, K.J. Demographic Differences in the Prevalence, Co-Occurrence and Correlates of Adolescent Bullying at School. Journal of School Health. 77: 2007. 623-629. Steinman, K.J., Hu Y. Substance use among American Indian youth in an Eastern city. Journal of Ethnicity in Substance Abuse. 6(1): 2007. 15-29. Ortega, A.N., Feldman, J.M., Canino, G., Steinman, K.J., Alegría, M. Co-occurrence of mental and physical illness in U.S. Latinos. Social Psychiatry and Psychiatric Epidemiology. 41(12): 2007. 927-934. Hong X, Song Y, Zheng, L, Sun, Q. Research update on air pollution on respiratory diseases. Journal of Chinese Preventive Medicine. 8: 2007. 494-496.

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Wickwire, E. M., Whelan, J.P., Meyers, A.W., Murray, D.M. Environmental correlates of gambling behavior in urban adolescents. Journal of Abnormal Child Psychology. 35(2): 2007. 179-190.

Dong Z, Zeitlin BD, Song W, Sun, Q, Karl E, Spencer DM, Jain HV, Jackson T, Nunez G, Nor JE. Level of endothelial cell apoptosis required for a signiﬁcant decrease in microvessel density. Experimental Cell Research. 313: 2007. 3645-3657. Tanenbaum, S.J. The role of public policy in the care of patients with adult congenital heart disease. Congenital Heart Disease. 2: 2007. 354-358. Bian Y, Knobloch TJ, Sadim M, Kaklamani V, Raji A, Yang GY, Weghorst CM, Pasche B. Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. Human Molecular Genetics. 16(24): 2007. 3128-3135. Mahajan A, Guo Y, Yuan C, Weghorst CM, Tsai MD, Li J. Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16. Journal of Molecular Biology. 373(4): 2007. 990-1005. Sarna, L., Bialous, S.A., Wewers, M.E., Froelicher, E.S., Balbach, E.D. Web log analysis of the ﬁrst two years of the Tobacco Free Nurses website. Online Journal of Nursing Informatics. 2007. http://eaa-knowledge.com/ ojni/ni/11_3/sarna.htm. French, G.M., Groner, J.A., Wewers, M.E., Ahijevych, K. Staying smoke free: An intervention to prevent postpartum relapse. Nicotine & Tobacco Research. 9: 2007. 663-670. Andrews, J., Felton, G., Wewers, M.E., Tingen, M., Waller, J. The effect of a multi-component smoking cessation intervention in African American women residing in public housing. Research in Nursing & Health. 30: 2007. 45-60. Wilkins JR III, Crawford JM, Stallones L, Koechlin KM, Shen L, Hayes J, Bean TL. Using Participant Event Monitoring in a Cohort Study of Unintentional Injuries Among Children and Adolescents. American Journal of Public Health. 97(2): 2007. 283-290.

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Grants and Contracts ARKES, HAL R, “Cognitive bases of hindsight effects,” National Science Foundation Social & Economic Sciences, $114,434 (2006-2008)

HOLTZHAUER, FRANCIS J, “Buckeye Bluegrass Regional Leadership Academy,” Centers for Disease Control and Prevention, $183,097 (2007-2010)

ARKES, HAL R, “Collaborative proposal: the reluctance to use decision aids,” National Science Foundation, $170,000 (2003-2008)

HOLTZHAUER, FRANCIS J, “Center for public health preparedness,” Centers for Disease Control and Prevention, $4,254,355 (2004-2009)

ARKES, HAL R, “EITM: Collaborative research: Reference point adaptation and mental accounting: Dynamic extensions of prospect theory,” National Science Foundation Social Behavioral and Economic Research, $176,285 (2004-2008)

HOLTZHAUER, FRANCIS J, “Community health assessment and transition, from direct health care to population based services, with intensive technical assistance and training,” Ohio Department of Administrative Services, $64,667 (2006-2008)

BALKRISHNAN, RAJESH, “Center for dermatology research,” Wake Forest University Health Sciences, $210,112 (2005-2008)

HOLTZHAUER, FRANCIS J, “Pennsylvania and Ohio public health training center,” University of Pittsburgh (Prime: Health Resources and Services Administration), $236,501 (2005-2008)

LEMESHOW, STANLEY A, “Innate immunity: Elucidation/modulation cancer therapy – Core B: Biostatistics,” National Cancer Institute, $704,126 (2002-2007)

HOLTZHAUER, FRANCIS J, “Public health workforce scholarship program,” Ohio Department of Administrative Services, $445,370 (2006-2010)

LEMESHOW, STANLEY A, “Genetic analysis of the breast tumor microenvironment – Core C,” National Cancer Institute, $430,234 (2004-2009)

HOLTZHAUER, FRANCIS J, “Public health workforce scholarship program,” Ohio Department of Health, $368,280 (2005-2009)

LEMESHOW, STANLEY A, “Core B Reducing cervical cancer in Appalachia,” National Cancer Institute, $796,874 (2003-2008)

HOLTZHAUER, FRANCIS J, “The Ohio public health leadership institute,” Association of Schools of Public Health/Centers for Disease Control and Prevention, $41,392 (2005-2007)

LIANG, SONG, “The socio-environmental determinants of Schistosomiasis re-emergence,” University of California at Berkeley (Prime: National Institute of Allergy and Infectious Diseases), $364,695 (2007-2012)

JARJOURA, DAVID, “After discharge management of low income frail elderly,” Summa Health System, $156,567 (2005-2008)

MCALEARNEY, ANN S, “Corporate universities in healthcare organizations,” American College of Healthcare Executives, $25,000 (2006-2008)

JARJOURA, DAVID, “Innate Immunity: Elucidation and Modulation for Cancer Therapy – Core B: Biostatistics,” National Cancer Institute, $206,049 (2007-2012)

MCALEARNEY, ANN S, “Improving cardiovascular care for minority Americans: Assessing organizational readiness to change,” George Washington University (Prime: Robert Wood Johnson Foundation), $159,667 (2005-2007)

BUCKLEY, TIMOTHY J, “Case study environmental monitoring in support of the Baltimore Region Environmental Justice in Transportation Project,” Morgan State University (Prime: U.S. Department of Transportation), $22,500 (2006-2007) BUCKLEY, TIMOTHY J, “Exposure assessment tools to assess health impact of trafﬁc,” Morgan State University (Prime: Environmental Protection Agency), $15,500 (2006-2008) CASWELL, ROBERT J, “The Ohio State University public health traineeship,” Bureau of Health Professions, Health Resources and Services Administration, $21,813 (2006-2008) DE MOOR, JANET S, “Cancer survivors employment patterns and consequent economic and health outcomes,” National Cancer Institute, $147,825 (2006-2008) DE MOOR, JANET S, “Cancer survivors’ intentions for work following diagnosis and treatment,” Lance Armstrong Foundation, $109,904 (2007-2008) DEMBE, ALLARD, “A study of employer-sponsored elder care programs,” The Retirement Research Foundation, $215,462 (2006-2008) DEMBE, ALLARD, “How demanding work schedules affect occupational injury risk,” W.E. Upjohn Institute for Employment Research, $74,386 (2006-2008) DEMBE, ALLARD, “Monitoring and evaluation of the Mansﬁeld STD Re-entry Testing Pilot Program,” Ohio Department of Rehabilitation and Correction, $101,816 (2007-2009)

KATZ, MIRA L, “Patient activation to increase colon cancer screening,” National Cancer Institute, $675,540 (2005-2010) LEE, MEI-LING TING, “Analysis of longitudinal CVD and cancer data,” Brigham & Women’s Hospital, Inc. (Prime: National Heart Lung and Blood Insitute), $19,041 (2005-2008) LEE, MEI-LING TING, “Connecting Ohio hospitals to the real-time outbreak and disease surveillance system,” Ohio Department of Health, $679,000 (2005-2007) LEE, MEI-LING TING, “Power and sample size for microarray studies,” National Human Genome Research Institute, $211,188 (2005-2007)

LEE, MEI-LING TING, “Threshold regression methodology for cancer risk assessment,” National Institute for Occupational Safety and Health, $727,514 (2006-2009) LEE, MEI-LING TING, “Genetic and epigenetic regulation of addiction genes,” National Institute on Drug Abuse, $66,412 (2006-2008) LEMESHOW, STANLEY A, “Individual and agedependent risk of cancer in Cowden Syndrome and Bannayan-Ruvalcaba-Riley Syndrome,” Cleveland Clinic Foundation, $49,554 (2005-2007)

MCALEARNEY, ANN S, “Improving Cardiovascular Care for Minority Americans: Facilitating Organizational Change,” George Washington University (Prime: Robert Wood Johnson Foundation), $100,891 (2007-2008) MURRAY, DAVID, “Center for prevention and early intervention,” Johns Hopkins University (Prime: National Institute of Mental Health), $48,390 (2005-2008) MURRAY, DAVID, “Etiology of childhood obesity: A longitudinal study (ECHO),” University of Minnesota (Prime: National Heart Lung and Blood Insitute), $307,725 (2006-2008)

MURRAY, DAVID, “Trial of activity in adolescent girls,” University of North Carolina at Chapel Hill (Prime: National Heart Lung and Blood Insitute), $112,217 (2005-2008) PASKETT, ELECTRA D, “A randomized study to prevent lymphedema in women treated for breast cancer,” Lance Armstrong Foundation, $247,500 (2006-2008) PASKETT, ELECTRA D, “A randomized study to prevent lymphedema in women treated for breast cancer,” Susan G. Komen Breast Cancer Foundation, $167,397 (2006-2008) PASKETT, ELECTRA D, “Appalachian cancer center network,” University of Kentucky (Prime: National Cancer Institute), $709,343 (2005-2008) PASKETT, ELECTRA D, “Breast cancer prevention through nutrition,” The Breast Cancer Research Foundation, $750,000 (2005-2008) PASKETT, ELECTRA D, “Cancer control and health outcomes committee chair support,” University of Chicago (Prime: National Cancer Institute), $317,136 (2002-2008) PASKETT, ELECTRA D, “Cancer control and prevention earmarks,” Centers for Disease Control and Prevention, $148,800 (2005-2007) PASKETT, ELECTRA D, “Cancer information service,” Wayne State University (Prime: National Cancer Institute), $427,292 (2005-2010) PASKETT, ELECTRA D, “Enhancing colorectal cancer screening in primary care,” National Cancer Institute, $291,833 (2007-2012) PASKETT, ELECTRA D, “Grandma’s hands,” Susan G. Komen Breast Cancer Foundation Columbus, $15,580 (2006-2007) PASKETT, ELECTRA D, “Healthy Ohio workers,” American Cancer Society Ohio, $2,840 (2007) PASKETT, ELECTRA D, “Ohio patient navigation program,” American Cancer Society, $1,404,180 (2005-2008) PASKETT, ELECTRA D, “Reducing cervical cancer in Appalachia,” National Cancer Institute, $8,269,750 (2003-2008) PIRIE, PHYLLIS L, “Evaluation of the Ohio Tobacco Cessation Centers project,” Ohio Tobacco Use Prevention and Control Foundation, $250,000 (2007-2008)

PIRIE, PHYLLIS L, “Netwellness,” Case Western Reserve University, $49,103 (2005-2007) PIRIE, PHYLLIS L, “Netwellness,” Delta Dental Plan of Michigan, Inc, $140,000 (2006-2007) POMPILI, MICHAEL J, “Measuring the value and effectiveness of public participation initiatives for the public sector: what to measure and a way to perform the measurement,” Kettering Foundation, $43,540 (2006-2007) SCHWARTZBAUM, JUDITH A, “Bone mineral density and DMPA in adolescent girls,” MetroHealth Medical Center, $3,798 (2006-2007) SCHWARTZBAUM, JUDITH A, “Genetic and molecular epidemiology of adult glioma,” University of California San Francisco (Prime: National Cancer Institute), $15,953 (2006-2007) SCHWARTZBAUM, JUDITH A, “Subcontract with Department of Radiation Sciences, Umeä University,” Umeä University, $17,163 (2006-2007) SHIPP, MICHELE, “What accounts for racial disparities in colon cancer?” National Cancer Institute, $280,002 (2004-2008) STEINMAN, KENNETH J, “Health behavior among religiously active Black youth,” Association of Schools of Public Health/Centers for Disease Control and Prevention, $1,093,745 (2003-2008) STEINMAN, KENNETH J, “Proﬁle of family violence in Ohio,” Health Policy Institute of Ohio, $79,222 (2007-2008) STEVENSON, KURT B, “Comparing administrative coding data to epidemiologic surveillance for infection control,” Association for Professionals in Infection Control and Epidemiology, $83,243 (2006-2007)

WEGHORST, CHRISTOPHER M, “Chemopreventive agent-responsive genes in oral cancer,” National Institute of Dental and Craniofacial Research, $373,750 (2004-2008) WEGHORST, CHRISTOPHER M, “Food-based modulations of biomarkers in human tissues at high-risk for oral cancer,” National Cancer Institute, $1,406,250 (2007-2012) WEGHORST, CHRISTOPHER M, “Genetic susceptibility and cervical cancer development,” Phi Beta Psi Sorority, $58,300 (2007-2008) WEGHORST, CHRISTOPHER M, “Prevention of oral cancer by dietary and topical administration of lyophilized strawberries,” California Strawberry Commission, $58,200 (2006-2007) WEGHORST, CHRISTOPHER M, “Prevention of oral cancer by strawberries with selenium assimilated in the fruit,” National Cancer Institute, $150,000 (2007-2009) WEWERS, MARY E, “Testing the effects of interactive computer programs for smoking cessation,” Walther Cancer Institute, $95,089 (2005-2008) WEWERS, MARY E, “The Ohio State University Health System Tobacco Treatment Center,” Ohio Tobacco Use Prevention and Control Foundation, $397,301 (2007) WEWERS, MARY E, “Tobacco free nurses,” University of California at Los Angeles (Prime: Robert Wood Johnson Foundation), $192,822 (2003-2008) WEWERS, MARY E, “Project #2 Reducing cervical cancer in Appalachia,” National Cancer Institute, $966,960 (2003-2008) WILKINS, JOHN R III, “Adherence to NAGCAT and injury risk reduction,” National Institute for Occupational Safety and Health, $1,083,875 (2003-2007)

STEVENSON, KURT B, “Ohio State health network infection control collaborative: Epi-centers for prevention of healthcare related infections,” Centers for Disease Control and Prevention, $785,222 (2006-2011)

WILKINS, JOHN R III, “Developing and evaluating new approaches to youth agricultural injury prevention,” National Institute for Occupational Safety and Health, $1,167,439 (2007-2010)

TANENBAUM, SANDRA J, “Evidence and

WILKINS, JOHN R III, “Hearing acuity and risk of

empowerment among consumers in the public mental health system,” Ohio Department of Mental Health, $68,225 (2005-2008)

unintentional injury,” National Institute for Occupational Safety and Health, $18,000 (2006-2008)

TANENBAUM, SANDRA J, “The role of consumeroperated services in a transforming public mental health system,” Ohio Department of Mental Health, $149,965 (2007-2010) WEGHORST, CHRISTOPHER M, “Chemoprevention of oral cancer in Appalachia,” American Cancer Society, $960,000 (2006-2010)

Advancing Knowledge. Improving Life.

MURRAY, DAVID, “Science-based prevention: Testing communities that care,” University of Washington (Prime: National Institute on Drug Abuse), $72,880 (2005-2008)

WILKINS, JOHN R III, “Ohio regional center for agricultural disease and injury,” National Institute for Occupational Safety and Health, $1,944,433 (2003-2008) WILKINS, JOHN R III, “Work-related injuries among immigrant workers,” The Research Institute at Nationwide Children’s Hospital (Prime: National Institute for Occupational Safety and Health), $12,093 (2006-2008)

Richard Lorenz, water utility manager at the Westerville Water Treatment Plant, shows students in the MPH program where tap water originates. The class is PUBH-EHS 731S Principles of Environmental Health Sciences.

COLLEGE OF

PUBLIC HEALTH College of Public Health The Ohio State University M116 Starling-Loving Hall 320 W. 10th Ave. Columbus OH 43210