Selank vs. Semax | How do these two peptides differ?

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Selankvs.Semax

Structure

Weight

Mechanism

Selank

Syntheticpeptideof7 aminoacids

Semax

Syntheticpeptideof7 aminoacids

Approximately777.9DaApproximately757.1Da

Modulatesserotonin andstresshormone

Increasesbrain-derived neurotrophicfactor

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Selankvs.Semax|Howdothesetwopept idesdiffer? -ByPhcokercom

Function

SideEffects

Regulatory

Status

Reducesstressand anxiety,enhancesmood

Generallywell-tolerated, withminimalreported sideeffects

Notapprovedbythe FDAformedicaluse, availableasaresearch chemical

Enhancescognitive functions,memory,and focus

Raresideeffectsmay includeheadachesor allergicreactions

NotapprovedbytheFDA formedicaluse,available asaresearchchemical

SelankandSemaxarebothnootropicpeptidesdevelopedinRussiathathavegained popularityamongpeoplelookingtoboosttheircognitivefunction.Intermsoftheir chemicalstructures,SelankandSemaxdifferinthespecificaminoacidsequences thatmakeupeachpeptide.

SelankiscomposedoftheaminoacidsThr-Lys-Pro-Arg-Pro-Gly-Pro,whileSemax whichisderivedfromtheACTHhormone,iscomposedoftheaminoacids Met-Glu-His-Phe-Pro-Gly-ProThesedifferencesinstructuremayaccountforsome ofthedifferencesintheireffectsonthebody.

Additionally,theprimaryfocusofSelankistotreatanxiety,depression,andother mooddisorders.WhileSemaxhasbeenshowntohavearangeofeffectsonthe nervoussystemandismoreknownforitscognitiveenhancements,whichinclude improvedmemory,focus,andlearningcapabilities.

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release (BDNF)levels
WhySelankIsOftenUsedWithSemaxTogether丨SelankAndSemax Combination?

PeptideSemaxisadrugwhichisusedmostlyinRussiaforabroadrangeof conditionsbutpredominantlyforitspurportednootropic,neuroprotective,and neurorestorativeproperties

BothPeptideSelankandSemaxactasMelanocortinStimulatingHormone-like Peptideswithinthebraintoinitiatewiderangingeffectsrelatedtobrainactivityand fitness.

Selankisoftenprescribedforitsanxiolyticproperties,immuneimprovement,gastric protection,andwithopioidandalcoholwithdrawal/dependence.WhileSemaxhas beenprescribedforanxiety,memoryimprovement,ischemicevents,stroke,nerve regeneration,ADHD,opioidwithdrawalandevenchronicdiseasessuchasALS, Parkinson’sDisease,andAlzheimer’s.

Asacombination,useSelankandSemaxtogetherhasapplicationsinimproving learningprocesses,exploratorybehavior,regenerationanddevelopment, nociceptiveandinflammatoryprocesses,acceleratenerveregenerationandimprove neuromuscularperformanceandoverallneuralhealth.

SelankandSerotonin

Serotoninisaneurotransmitterthatactsasahormone,functioningbycarrying messagesbetweenournervecellsandthroughoutthebody.Becauseserotonin,we cancontrolourmood,appetite,sleep,memory,learning,andsocialbehavior.

Although90%ofserotoninisfoundinthegastrointestinaltractandonly10%is producedinourbrain,thissubstanceisaprimaryfactorindepressionandanxiety. Becauseserotoninistooimportant,therefore,alackofserotoninmayleadto psychologicalproblems.

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StudiesshowthatSelankincreaseserotoninlevelsbycorrectinganydecreasein serotoninmetabolism.

Accordingtoastudy,selankenhancesthemetabolismofserotonininthebrainstem 30minutesafterinjectiontoanimalsubjectsThiseffectofselankissuperiorto tuftsin,asthelatterdoesn’tcauseanychangesinserotoninlevels.

ReferencedCitations

[1]UchakinaON,UchakinPN,MiasoedovNF,AndreevaLA,ShcherbenkoVE,Me zentsevaMV,etal.(2008)."[Immunomodulatoryeffectsofselankinpatientswi thanxiety-asthenicdisorders]".ZhurnalNevrologiiIPsikhiatriiImeniS.S.Korsak ova108(5):71–75PMID18577961

[2]NarkevichVB,KudrinVS,KlodtPM,PokrovskiĭAA,KozlovskaiaMM,Maĭskiĭ

AI,RaevskiĭKS(2008)."[Effectsofheptapeptideselankonthecontentofmono aminesandtheirmetabolitesinthebrainofBALB/CandC57Bl/6mice:acom parativestudy]".Eksperimental'naiaiKlinicheskaiaFarmakologiia.71(5):8–12.P MID19093364

[3]SemenovaTP,KozlovskiĭII,ZakharovaNM,KozlovskaiaMM(August2010)." [Experimentaloptimizationoflearningandmemoryprocessesbyselank]"Eksp erimental'naiaiKlinicheskaiaFarmakologiia73(8):2–5PMID20919548

[4]SemenovaTP,KozlovskiĭII,ZakharovaNM,KozlovskaiaMM(2009)."[Compari sonoftheeffectsofselankandtuftsinonthemetabolismofserotonininthe brainofratspretreatedwithPCPA]".Eksperimental'naiaiKlinicheskaiaFarmakol ogiia.72(4):6–8.PMID19803361

[5]InozemtsevaLS,KarpenkoEA,DolotovOV,LevitskayaNG,KamenskyAA,An dreevaLA,GrivennikovIA(2008)."IntranasaladministrationofthepeptideSela nkregulatesBDNFexpressionintherathippocampusinvivo"DokladyBiologi calSciences.421:241–243.doi:10.1134/s0012496608040066.PMID18841804.S2 CID40709909

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[6]KostNV,SokolovOI,GabaevaMV,GrivennikovIA,AndreevaLA,Miasoedov NF,ZozuliaAA(2001)."Semaxandselankinhibittheenkephalin-degradingenz ymesfromhumanserum"BioorganicheskaiaKhimiia(inRussian)27(3):180–1 83doi:101023/A:1011373002885PMID11443939S2CID26029820

[7]Solov'evVB,GenginMT,SollertinskaiaTN,LatynovaIV,ZhivaevaLV(2012)" [Effectofselankonthemaincarboxypeptidasesintheratnervoustissue]".Zh urnalEvoliutsionnoiBiokhimiiIFiziologii(inRussian).48(3):254–257.PMID22 827026

[8]SarkisovaKI,KozlovskiĭII,KozlovskaiaMM(2008)."[Effectsofheptapeptides elankongenetically-basedandsituation-provokedsymptomsofdepressionin behaviorinWAG/RijandWistarrats,andinBALB/cmice]".ZhurnalVyssheiNe rvnoiDeiatelnostiImeniIPPavlova(inRussian)58(2):226–237PMID186617 85

[9]“СЕМАКС:лекарственноесредствоширокогоспектрадействияэффективн ыйстимуляторнервнойсистемы”[SEMAX:abroad-spectrumdrugeffectives timulantofthenervoussystem].InstituteofMolecularGenetics(inRussian).M oscow.Archivedfromtheoriginalon2011-07-22

[10]Solov’evVB,GenginMT,SollertinskaiaTN,LatynovaIV,ZhivaevaLV(2012).

“[Effectofselankonthemaincarboxypeptidasesintheratnervoustissue]” ZhurnalEvoliutsionnoiBiokhimiiIFiziologii(inRussian)48(3):254–257PMID 22827026

[11]KorneevEA,KazakovaTB(1999).“Currentapproachestotheanalysisofth eeffectsofstressonmetabolicprocessesincellsofthenervousandimmune systems”.Med.Immunology.1(1–2):17–22

[12]DolotovOV,KarpenkoEA,InozemtsevaLS,SeredeninaTS,LevitskayaNG,R ozyczkaJ,etal.(October2006).“Semax,ananalogofACTH(4-10)withcogniti veeffects,regulatesBDNFandtrkBexpressionintherathippocampus”Brain Research.1117(1):5460.doi:10.1016/j.brainres.2006.07.108.PMID16996037.S2CI D27592503

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[13]EreminKO,KudrinVS,GrivennikovIA,MiasoedovNF,RayevskyKS(2004).E ffectsofSemaxondopaminergicandserotoninergicsystemsofthebrain.Dokl adyBiologicalSciences394(1–6):1–3doi:101023/b:dobs00000171142447440 PMID15088389S2CID12955434

[14]Jumpupto:abEreminKO,KudrinVS,SaransaariP,OjaSS,GrivennikovIA, MyasoedovNF,RayevskyKS(December2005).“Semax,anACTH(4-10)analogu ewithnootropicproperties,activatesdopaminergicandserotoninergicbrainsy stemsinrodents”.NeurochemicalResearch.30(12):1493–1500.doi:10.1007/s1 1064-005-8826-8.PMID16362768.S2CID38202287

[15]PaeCU(January2008).“Therapeuticpossibilityof“Semax”fordepression” . CNSSpectrums.13(1):2021.doi:10.1017/S1092852900016102.PMID18204410

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