9FrequentlyAskedQuestionsAboutCagriSema
-ByPhcokerCagrilintideandSemaglutideoverview
WhatisCagrilintide?
Asanon-selectiveagonistforbothamylinreceptor(AMYR)andalcitoninGprotein-coupled receptor(CTR),itconfidentlyreducesfoodintake,resultinginsignificantweightloss.Cagrilintide peptideisanexcitingamylinanalogthathasshownstrongpotentialinthestudyofobesity.
CagrilintideiscurrentlybeingtestedaloneandincombinationwithSemaglutideforthetreatment ofobesityandtype2diabetes.
WhatisSemaglutide?
Semaglutideisanamazingpeptidebelongingtotheclassofmedicationsknownasglucagon-like peptide-1receptoragonists(GLP-1RAs)!Thismedicationistrulyagame-changer!Itexpertly mimicstheGLP-1hormone,significantlyincreasesinsulinrelease,effectivelylowersglucagon release,expertlydelaysgastricemptying,andgreatlyreducesappetite.
WhatisCagrilintide/semaglutide?
AfixeddosecombinationofCagrilintideandSemaglutideisunderdevelopmentforthetreatmentof type2diabetes,obesityandmetabolicdysfunction-associatedsteatohepatitis(MASH)It administeredthroughsubcutaneousroute.Cagrilintideisalong-actingamylinanaloguewhichacts bytargetingcalcitoninreceptor,receptoractivitymodifyingproteins1,2,3(RAMP1-3)and
semaglutideactsbytargetingglucagonlikepeptide1receptor(GLP1R).
9FrequentlyAskedQuestionsAboutCagriSema
IsCagriSemaapproved?
Althoughsemaglutideisapprovedfortreatmentofobesity,tirzepatideandCagriSemaarestillin clinicaltrialsandnotyetapprovedforobesity.
WhataretheresultsoftheCagriSematrial?
Inthisexploratorytrial,32-weektreatmentwithCagriSemaresultedinaclinicallyrelevant reductioninHbA1cof2·2percentagepointsversus1·8percentagepointswithsemaglutideand0·9 percentagepointswithcagrilintide
IsCagriSemaphase2diabetes?
Interpretation:Inpeoplewithtype2diabetes,treatmentwithCagriSemaresultedinclinically relevantimprovementsinglycaemiccontrol(includingCGMparameters).Themeanchangein HbA1cwithCagriSemawasgreaterversuscagrilintide,butnotversussemaglutide
Iscagrilintidethesameassemaglutide?
Cagrilintideisalong-actingamylinanaloguewhichactsbytargetingcalcitoninreceptor,receptor activitymodifyingproteins1,2,3(RAMP1-3)andsemaglutideactsbytargetingglucagonlike peptide1receptor(GLP1R).
Whataretheresultsofphase3ofCagriSema?
Inthephase3trial,at72weeksoftreatmentwiththemaximumdoseofZepbound,patients achievedadecreaseinbodyweightfromthebaselineof209%Ontheotherhand,inCagriSema's phase2trial,thecombinationtherapycausedadecreaseinbodyweightatweek32oftreatmentof 15.6%frombaseline.
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WhatisthegenericnameforCagriSema?
Cagrilintide/semaglutide,marketedasCagriSema,isacombinationofcagrilintide,adualamylin andcalcitoninreceptoragonist,andsemaglutide,aGLP-1agonistItisinjectedonceweeklyandis beingtestedintype2diabetesandobesity
WhomakesCagriSema?
NovoNordisklaunchestrialofpipelinedrugCagriSemaversusnewlyapprovedZepboundClinicalTrialsArena.
IsCagriSemasafe?
Inapreviousphase2trial,CagriSemawasfoundtobesafeandwell-toleratedBackinMarch, MartinHolstLange,executivevicepresidentatNovoNordiskDevelopment,saidhewas 'encouraged'bythe'impressivephase2results.
WhatisthedifferencebetweenAmycretinandCagriSema?
Amycretinis,inasense,amorestreamlinedversionofCagriSema.Inadditiontoaneasierdelivery route,amycretin'sabilitytoreduceweightcouldmakeitatopsellerPatientsrandomizedtoreceive itexperienceda12%placebo-adjustedweightreductionafter12weeksoftreatment
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Authorofthisarticle:
DrJeanZenggraduatedfromking’scollegelondonFacultyofLifeSciences&Medicine
ScientificJournalpaperAuthor:
1.CarolineMApovian
BrighamandWomen'sHospital,HarvardMedicalSchool,Boston,MA02115,USA
2MarieEMcDonnell
BrighamandWomen'sHospital,HarvardMedicalSchool,Boston,MA02115,USA
3JuanPFriasMD
Correspondenceto:DrJuanPFrias,VelocityClinicalResearch,LosAngeles,CA90057,USA
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