Urolithin B Powder manufacturer-Factory price

Chemical information of Urolithin B Product Name

Urolithin B powder

Chemical Name

3-hydroxy-6H-benzo[c]chromen-6-one 3-hydroxybenzo[c]chromen-6-one Uro-B 3-Hydroxyurolithin

CAS Number

1139-83-9

InChIKey

WXUQMTRHPNOXBV-UHFFFAOYSA-N

SMILE

C1=CC=C2C(=C1)C3=C(C=C(C=C3)O)OC2=O

Molecular Formula

C13H8O3

Molecular Weight

212.2 g/mol

Monoisotopic Mass

212.047344 g/mol

Melting Point

247 °C

Color

white to beige powder

Solubility

DMSO: soluble5mg/mL, clear (warmed)

Storage temp

2-8°C

Application

Urolithin B has been used in bodybuilding and supplements area.

What is Urolithin B ? Urolithin B powder?

Urolithin B powder ( CAS NO :1139-83-9) is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate,strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.

Urolithin B decreases protein degradation and induces muscle hypertrophy. Urolithin B inhibits the activity of aromatase, an enzyme that interconverts estrogen and testosterone.

Urolithin B is a natural product with antiproliferative and antioxidant activity. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also

display estrogenic and/or anti-estrogenic activity.

What is Urolithin B use for? Urolithin B (UB) benefits Urolithin B's Benefits: Stimulates Muscle Protein Synthesis Reduces Muscle Protein Breakdown May Have Muscle Protective Effects May Have Anti-Aromatase Properties

Urolithin B for muscle mass Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.

When compared to testosterone, Urolithin B when taken at 15 uM increased androgen receptor activity by 90% while testosterone was only able to accomplish increased receptor activity of 50% at 100uM. This means that it takes a lot less Urolithin B to increase androgen activity more effectively then the higher amount of testosteronewhich increases androgen activity less effectively.

Moreover, most effective 15uM of Urolithin B larger muscle protein synthesis via 96% when in comparison to 100uM of insulin, which larger muscle protein synthesis via most effective 61%.

The belief is that it takes a long way much less Urolithin B to extend muscle protein synthesis with a lot upper degree of effectiveness.

This studies show that Urolithin B can inhibit protein catabolism while simultaneously increase protein synthesis, it is a natural ingredient that helps to build lean muscle while preventing muscle breakdown.

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.

Reference: [1]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia.

Phytomedicine. 2019 Mar 1;55:50-57. [2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597.

[2]. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Lee G, Park JS, Lee EJ, Ahn JH, Kim HS. [3]. Urolithin B, a newly identified regulator of skeletal muscle mass. Rodriguez J, Pierre N, Naslain D, Bontemps F, Ferreira D, Priem F, Deldicque L, Francaux M. [4]. Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway. Zheng D, Liu Z, Zhou Y, Hou N, Yan W, Qin Y, Ye Q, Cheng X, Xiao Q, Bao Y, Luo J, Wu X.