What
is
nicotinamide
mononucleotide
(NMN)? Nicotinamide Mononucleotide (“NMN” and “β-NMN”) is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NAD+). Nicotinamide mononucleotide is a precursor molecule for the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a coenzyme that participates in the production of cellular energy and repair. NMN helps maintain cellular levels of NAD+, thereby facilitating NAD+-dependent cellular activities, such as mitochondrial metabolism, regulation of sirtuins, and PARP activity. Animal studies have demonstrated that NMN administration is effective in increasing NAD+ levels across multiple tissues while improving the outcome of a variety of age-related diseases.
What is NAD+ NAD+ is an essential coenzyme required for life and cellular functions. Enzymes are catalysts that make biochemical reactions possible. Coenzymes are ‘helper’ molecules that enzymes need in order to function. This special molecule is part of the biochemical pathways that converts food into energy within the mitochondria. Additionally, NAD+ protects tissues from free radicals, supports innate immune function, boosts DNA repair, increases energy, and extends life span. We manufacture NAD+ from vitamin B3 delivered in our diet, but the majority of the NAD+ in the body is generated from the intricate recycling system within our cells. However, and its depletion has been implicated in the onset and progression of multiple age-related conditions such as metabolic dysregulation and neurodegenerative disease.