NAD+ Precursors in Aging: Role of The (NR) Nicotinamide Riboside Chloride Fact in Anti-aging

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NAD+ Precursors in Aging: Role of The (NR) Nicotinamide Riboside Chloride Fact in Anti-aging

Nicotinamide riboside (NR) and nicotinamide riboside (Chloride) Nicotinamide riboside (NR) chloride is a chlorinated form of nicotinamide riboside (NR).

1.What is Nicotinamide Riboside (NR)?

NR is a form of vitamin B3 or niacin. The compound was discovered in the 1940s as a growth factor for H. influenza. At the onset of the 21st century, scores of studies would prove that NR is a precursor of NAD+. In the human body, this nutrient lowers cholesterol levels, eases the risk of cardiovascular diseases, boosts brain functions, and alleviates arthritis.

Nicotinamide riboside (NR) is a pyridine-nucleoside, serving as a precursor to NAD+ (Nicotinamide adenine dinucleotide). NAD+ fuels most biological functions including DNA repair, generation of cellular energy, setting the body’s circadian rhythm, and more. Unfortunately, these molecules naturally decline with senescence.

2.What is Nicotinamide Riboside (NR) Chloride?

Nicotinamide Riboside (NR) chloride (NIAGEN) is a derivative of NR and chlorine. The compound augments the levels of NAD+ and activates SIRT1 and SIRT3. It reverses aging by enhancing oxidative metabolism and countering diet-related metabolic

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comorbidities.

In the US, nicotinamide riboside chloride is generally recognized as safe. Therefore, it is an approved dietary ingredient for use in protein shakes, vitamin waters, gums, and related supplements.

3.Conclusion Humanity has been countering aging by targeting the skin. At one point, you must have come across some anti-aging creams for clearing deep facial wrinkles, sagging skin, and blotchiness. However, these treatments are erratic and short-term. The guaranteed way of aging gracefully is through establishing the biological changes behind senescence and dealing with the root cause.

Researchers have since established the link between low NAD+ levels and age-related diseases. This radical discovery has been the icing on the cake in the medical scope by augmenting the probability of reversing the aging process. For this reason, nicotinamide riboside chloride powder has frequented the corridors of clinical research labs due to its efficacy in overturning the biological clock.

The Chemical Specification of Nicotinamide Riboside (Chloride) Powder Product Name

Nicotinamide riboside chloride (NR-CL) (23111-00-4)

Chemical Name

NRC;3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1-( β -D-ribofuranosyl)pyridinium chloride; Nicotinamide B-D

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Riboside Chloride(WX900111); NR-CL; CAS Number

23111-00-4

InChIKey

YABIFCKURFRPPO-IVOJBTPCSA-N

SMILE

C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-]

Molecular Formula

C11H15ClN2O5

Molecular Weight

290.7002

Monoisotopic Mass

290.066949 g/mol

Melting Point

N/A

Color

white

Storage temp

-20°C Freezer

Application

dietary supplements, pharmaceutical field

Knowing the Benefits of Nicotinamide riboside (NR), what are the Benefits of Nicotinamide Riboside Chloride?

The benefits of nicotinamide riboside chloride vs nicotinamide riboside are similar since they both work to activate NAD and sirtuin 1 proteins.

Healthy Metabolism for Managing Obesity Scores of research have proven the efficacy of nicotinamide riboside chloride in reducing weight. Users can lose up to 10% of their body fat without appetite suppression or physical training.

Taking the drug helps lower LDL cholesterol while raising the levels of good 3

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cholesterol. This happens when it holds back the action of the enzymes responsible for the synthesis of triglycerides. Consequently, the production of low-density lipoproteins slows down.

Nicotinamide riboside chloride benefits overweight patients with diabetes. The supplement boosts metabolism by improving glucose intolerance Neuroprotection When NAD levels fall below optimum, your neurological system and cognitive health may be at stake. Take, for example, patients with Alzheimer’s disease exhibit a low concentration of NAD+ and mitochondria dysfunction.

Among the clinical nicotinamide riboside chloride uses, the management of neurodegeneration in aging tops the list. The drug acts against intracerebral damage, ischemic stroke, neurological inflammation, and neuronal death.

Anti-aging Supplement One of the key Nicotinamide riboside chloride uses includes promoting healthy aging.

The compound leads to an increase in NAD production, which plays a significant role in the cell. For instance, it raises the cellular energy levels within the muscles, liver, and kidneys. Besides, Nicotinamide riboside chloride prevents senescence by increasing the circulation of blood in these vital organs.

DNA Repair Nicotinamide riboside chloride benefits genetic makeup by repairing the old and damaged DNA. If the concentration of NAD falls, the injured deoxyribonucleic acid

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may trigger the reactive oxygen species, leading to oxidative stress, and susceptibility to cancer.

How Can Nicotinamide Riboside Chloride Reverse Aging?

During aging, the body experiences some physiological changes as the cellular functions fall back. For instance, the body depletes NAD+ and SIRT1 proteins than it can synthesize. Low levels of these coenzymes accelerate senescence while sparking off age-related comorbidities including diabetes, cardiovascular diseases, and obesity.

Administering nicotinamide riboside chloride benefits the immune system by boosting the blood vessels, such as lymphocytes and leucocytes. The compound upregulates the synthesis of NAD+, hence, stepping up the levels of SIRT1 proteins.

Consequently, SIRT1 slows down vascular aging by increasing blood flow to the skeletal muscles, cardiovascular system, and the neurological tissues.

Besides, nicotinamide riboside chloride supplement reverses aging by producing more NAD+ to aid in DNA repair within the cellular structure. This effect prevents oxidative stress The available research also confirms that nicotinamide riboside chloride counters bone density depletion, a decrease in tear production, and fundus hypopigmentation.

All these conditions are pervasive among the elderly.

NAD⁺ Precursors: Nicotinamide Riboside Chloride vs Nicotinamide Mononucleotide There are over five NAD+ precursors but for now, we can shift our focus to nicotinamide riboside chloride vs nicotinamide mononucleotide (NMN).

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These two compounds augment the NAD+ levels in the body to improve cellular functions and slow down senescence.

What tells these two apart is that NMN is not a vitamin B3 form. The chemical does not penetrate through the cell until it converts to nicotinamide riboside. The reason is that its molecular size is larger relatively bigger than that of nicotinamide riboside chloride powder. Due to this property, the bioavailability of NMN and its prospects of activating NAD+ levels has been a bone of contention in the research realm.

According to Dr. Sinclair, a geneticist at Harvard University, the efficiency of NMN is unmatched. He confesses to using this supplement, which makes him feel young and rejuvenated. Sinclair equals the effectiveness of NMN to running in a treadmill. The scientist noted that it improves blood circulation, promotes muscle endurance, and efficient metabolism.

Conversely, Nicotinamide riboside chloride is directly taken up by the cell. The molecule is a vitamin B3 alternative. It will augment NAD+ levels by over 60% in the human body. Unlike most NAD precursors, which are on the FDA’s watch list, nicotinamide riboside (NR) chloride is in the whitelist of GRAS (Generally Recognized as Safe) food products.

Why not take NAD powder directly? Nicotinamide Riboside Chloride vs Nicotinamide Adenine Dinucleotide (NAD) Since our focus is about elevating NAD in the body, you are probably questioning why the fuss over nicotinamide riboside chloride. Shouldn’t you administer NAD directly 6

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into your system rather than going through the hassle of using intermediates such as NIAGEN, NR, or NMN? Well, allow me to brief you about nicotinamide riboside chloride vs nicotinamide adenine dinucleotide.

The principal reason why you should never take NAD directly is that the biomarker is relatively impermeable to the cell.

The plus of using nicotinamide riboside chloride vs nicotinamide adenine dinucleotide is that the former is quite permeable to the plasmic membrane. Its absorption rate is significantly higher through the digestive system, into the bloodstream, and finally to the brain.

Nicotinamide riboside (NR) Chloride Dosage: How to Use? In 2016, the nicotinamide riboside chloride supplement won the GRAS status. A year before, the FDA had approved of it as a source of niacin and a dietary ingredient at a daily dose of 180mg.

Currently, the maximum licit nicotinamide riboside chloride dosage levels to 300mg per day. However, in some human trials, the subjects would ingest up to 2000mg of the drug. You should note that exceeding a dose of 500mg will likely lead to insufferable nicotinamide riboside side effects.

The niacin dose only applies to healthy adults, inclusive of expectant women and lactating moms.

Nicotinamide Riboside Chloride Side Effects: Is it Safe to Use Nicotinamide Riboside Chloride Supplement?

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Nicotinamide riboside chloride powder is safe and it holds the highly coveted status of GRAS substances. This fact doesn’t mean that the compound has no adverse symptoms. After all, water is life but it also drags some negative upshots when you abuse it. To counter the side effects, ensure that your Nicotinamide riboside chloride dosage is as low as possible.

Some of the adverse reactions include; ♦Stomach upset ♦Nausea ♦Vomiting ♦Diarrhea ♦Skin reactions such as rash and increased bruising Besides the above nicotinamide riboside chloride side effects, you are also likely to experience weight loss. However, this outcome is a blessing in disguise especially if you are overweight, obesity, or you’re trying to keep your weight in check.

Where to Buy (NR) Nicotinamide Riboside Chloride in Bulk?

You can make a nicotinamide riboside chloride buy at an online store. Whether you want the pharmaceutical-grade powder in bulk or some food-grade supplement, ensure to look out for a genuine supplier. The plus of virtual shopping is that you can compare pricing and check out real-time customer feedback. However, you are also likely to fall for counterfeits.

We are a trusted brand and all our products adhere to the quality control measures.

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We deal with different chemicals and dietary supplements. Contact us for your order and a friendly quotation.

References [1]Conze, D., Brenner, C., & Kruger, C.L. (2019). Safety and Metabolism of Long-Term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Healthy Overweight Adults.

Scientific Reports.

[2]Bogan, K.L. & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ precursor Vitamins in Human Nutrition.

Annual Review of Nutrition.

[3]Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside – The Current State of Research and Therapeutic Uses.

[4]Turck, D., Castenimiller, J., et al. (2019). Safety of Nicotinamide Riboside Chloride as a Novel Food Pursuant to Regulation (EU) 2015/2283 and Bioavailability of Nicotinamide from this Source, in the Context of Directive 2002/46/EC. EFSA Journal.

[5]Elhassan, Y.S. et al. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-Inflammatory Signatures. Cell Reports.

[6]Aman, Y., Qiu, Y., Tao, J., & Fang, E.F. (2018). Therapeutic Potential of Boosting NAD+ in Aging and Age-Related Diseases. Translational Medicine of Aging.

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