Corporate Presentation - Pharma Inventor Inc.

Page 1


Team Members…

Company Management

Worldwide Education & Research Work Experience

• Pre-PhD training at the Indian Institute of Chemical Technology (India)

• Ph.D. in Organic Synthesis from Hamburg & Kiel Universities (Germany)

• Post Doctoral Fellow at the University of British Columbia (Canada)

• Senior Research Scientist positions at Albany Molecular Research Inc.

• Published several research articles in Peer-reviewed International journals

• Held Teaching and leadership roles prior to incorporating Pharma Inventor Inc.

Prof. Thisbe Lindhorst

Company Management

Recognitions & Awards

• Sharabayya Gada Gold Medal

• Council of Scientific & Industrial Research (CSIR) Fellowships

• Wiley book Prize (Kiel, Germany)

• Best Researcher (CytoMed Inc. USA)

• Employee of the Year, 2005 (NAEJA Pharmaceuticals Inc. ) Leadership

Industrial Work Experience

• IICT-Cytomed Inc. (USA & India)

• Xenon Pharmaceuticals Inc. (Canada)

• NAEJA Pharmaceuticals Inc. (Canada)

• Albany Molecular Research Inc. (USA)

• Phyton Biotech LLC. (Canada)

• Methylation Sciences Inc. (Canada)

• Multiple clinical development candidates

Pharma Inventor Advantages ...

• Vancouver based Business, Easy access & Quick Turn-around Times

Vancouver is one of the most livable cities in the World

• Family Owned Business, Founders Themselves are Skilled Scientists

Vancouver is a magnet for global and regional scientific talents

• Inventive, Cost-Effective, High Quality & Time Efficient Services

Positioned to deliver high quality services with increased productivity at reduced cost

• Absolute IP Protection

Our clients own Intellectual Property (IP) and we work under strict confidentiality.

• State-of-the-Art Scientific Infrastructure

Opportunities for scaled growth

• Strict Adherence to Health & Safety Standards

WorkSafe BC and WHMIS Health & Safety Standards in Practice

Comprehensive Services...

PHARMA INVENTOR INC,. is a Canadian Preclinical Chemistry R&D and Analytical services company established to serve the needs of Pharmaceutical, Biotech and Agrochemical industries as well as research institutes/academic research groups in North America to support their innovative Chemistry R&D/Analytical/ Biological testing activities.

Drug Discovery Capabilities ...

In-house Chemistry Capabilities …

• Biological Target Selection and Database Review

Literature review using Sci-Finder, Reaxys, POC data search in patents and research articles.

• Novel Structure Design and Synthesis of Compound Libraries

Compound design & synthesis based on biological activity, selectivity, pharmacokinetic (i.e. ADME) and toxico-kinetic properties, as well as novelty search for patentability

• Hit to Lead Generation

Lead hopping and screening using Biochemical assays.

• Lead Optimization

Skilled medicinal chemists with proven track record of innovative patents and publications.

• Back-up Candidate Identification

Synthesize diverse chemical scaffolds with optimized pharmacokinetic & toxicology properties.

• Process Development

Green and environmentally friendly synthetic processes, technologies for manufacturing under cGMP conditions.

In-house Chemistry Capabilities …

Custom Peptide Synthesis…

PHARMA INVENTOR INC. is very proud to offer high quality and cost-effective custom peptide synthesis service in a timely manner regardless of peptide complexity. Our extensive experience in peptide synthesis technologies has afforded us the capability to take on a wide range of sequences, purity levels, and modifications to meet our client's research/product needs.

PHARMA INVENTOR Advantages

 Consistent Results: >99% success rate

 Large number of modification

 High purities: from 90% to >99%

 Best Quality Control

 No limitation

 Rapid Turnaround

 Competitive pricing

UPLC-CAD Analysis…

PHARMA INVENTOR INC. is very pleased to offer charged aerosol detector (CAD) analysis, which is highly sensitive, consistent, high precision and wide dynamic range system to provide accurate results for any non-volatile and many semi-volatile analytes.

Applications of CAD Analysis:

 Lipids

 Proteins

 Peptides

 Carbohydrates

 Polymers

 Steroids

 Oligosaccharides

 Surfactants

 Polysorbate quantification and profiling

SFC Purification Capabilities…

PHARMA INVENTOR INC., offers chiral purification services using preparative Supercritical Fluid Chromatography (Prep-SFC) and Preparative High Performance Liquid Chromatography (PrepHPLC). Our expert scientists produce high quality compounds from milligrams to hundreds of grams in a fast turnaround time.

Analytical SFC

PHARMA INVENTOR Advantages

 Purification of chiral compounds.

 Isolation of impurities in starting materials, intermediates, APIs and drug products.

 Purification of either single compounds or libraries.

 High-throughput purification for synthetic compounds.

 Chiral separation method development.

 Rapid Turnaround.

 Competitive pricing.

Preparative SFC

Radiopharmaceuticals…

PHARMA INVENTOR INC., is proud to announce radiolabeling capabilities for synthesis, method development and manufacturing of radiolabeled (C-14 and Tritium) small molecules of almost any complexity for use in pre-clinical and clinical studies.

PHARMA INVENTOR Advantages

Radiosynthesis and synthetic routes development.

Synthesis of radiolabeled (C-14 and Tritium) APIs to GMP.

Full Certificate of Analysis and analytical profile.

Chiral separation and salt formation.

Storage and management of radiolabeled compounds.

Safe and fast shipment to all destinations in North America.

Rapid re-purification service.

Competitive pricing.

Supporting AI in Drug Discovery…

PHARMA INVENTOR INC., has a great reputation for its exceptional track record and commitment to excellence. With our expanding scientific team of highly skilled Medicinal/Synthetic Chemists, we consistently deliver outstanding results that meet the highest professional standards. We have an exquisite reputation to provide medicinal chemistry support to synthesize novel lead drug candidates identified by the Deep Docking AI platform, for several Pharma Industries across North America. Our dedication to accuracy, clear communication and timely execution ensures that your customized synthetic chemistry project is handled with the utmost care and precision.

https://www.pharmaceutical-technology.com/news/ rakovina-expands-collaborations-to-leverage-ai-

Benefits of AI in Drug Discovery

Co-crystal & Salt Screening

Selecting the optimal solid form of an API during early drug development can mitigate the risk of failure later in development. This can be achieved through polymorph, salt and cocrystal screening.

PHARMA INVENTOR Co-crystal, Salt and Polymorph Screening Services

 Co-crystal Screening : Choose suitable co-formers to design experiments; Co-crystal form identification and characterization; Thermodynamic phase relationship study; Stability and solubility evaluation; Co-crystal form recommendation.

 Salt Screening: Design various salt-forming experiments according to the physicochemical

Focused Form Screening

o Physiochemical Property

o Developability assessment

PHARMA INVENTOR Capabilities - Solid Form Screening

Polymorph/Salt/Co-crystal Screening

o Thermodynamic phase relationship

o Stability and solubility evaluation

o Optimal form recommendation

Extensive Form Screening

o Form evaluation

o Patenting of polymorph/salt

Diverse Synthesis Capabilities …

Thio-CMI-977

5-LO Inhibitor

Anti-asthmatic agent

Setmelanotide

Metal Catalyst (R,R)-Salen Co (III) OAc

Stable, Brick Red Solid

Key Intermediates

Analytical Services…

PHARMA INVENTOR INC.

provide broad range of analytical services including Method

Development, Validation, Subject sample analysis, Quality Control Testing and Stability Studies.

Pharmaceutical Compounds

Natural Health Products

Herbal and Botanical Products/ Pesticides Analysis

o Ultra Higher Performance Liquid Chromatography - Mass Spectrometer (Waters UPLC-MS/MS)

o UPLC-MS/MS integrated with Charged Aerosol Detector (CAD)

o Tripple Quadrupole Liquid Chromatography - Mass Spectrometer (TQD LC-MS/MS)

o High Performance Liquid Chromatography (Agilent 1100 HPLC)

o Preparative High Performance Liquid Chromatography (Agilent Prep 1200 HPLC)

o Karl Fischer Titration (KF Titration)

o Nuclear Magnetic Resonance (NMR) Spectrometer (1D, 2D, 13C, 31P, 15N, 19F on 400 MHz & 600 MHz)

o Trapped Ion Mobility Spectrometry coupled to High-Resolution Time-of-Fight Mass Spectrometry (Bruker TIMS TOF)

o Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

o Multi Angle Light Scattering (MALS)

o Dynamic Light Scattering (DLS)

o Viscometer

o Fourier Transfer-Infrared Spectroscopy (FT-IR) with attenuated total reflectance (ATR)

o Gas Chromatograph (GC) with Flame Ionization Detector (FID) and Thermal Conductivity Detector (TCD), Gas Chromatograph Mass Spectrometry (GC-MS)

o Fluorescence Spectrophotometer

o Polarimeter, Stopped Flow Instrument

o Lambda 25 UV/Vis Spectrophotometer

Cosmetics Products

Cannabinoid/Terpenoid Compounds (Under development)

Analytical Services…

Chemistry Testing Services

 Method development & validation

 Analysis of Lipids and Carbohydrates

 using Charged Aerosol Detector (CAD)

 Residual solvent analysis

 Physicochemical techniques such as:

UPLC-CAD, LC-MS/MS

UV, XRPD, TGA, DSC, CE-DAD, FT-IR, GC-MS-FID…

 Elemental impurities

 Solubility & Comparative

 Drug product dissolution & release testing

 Pharmacopeial / raw

 Investigative analysis of drug products

 Karl Fischer Moisture Analysis

 Validation of cleaning

Biopharmaceutical Testing Services

 Amino acid sequence analysis

 Structural characterization and confirmation

 Physio-chemical properties

Analytical support for clinical trial supplies

 Toxic heavy metals analysis (As, Hg, Cd, etc.)

 Comparative dissolution testing

Bioanalytical Services…

PHARMA INVENTOR INC. provides method development, method validation and sample analysis for all relevant in-vitro and in-vivo matrices. Our expert bioanalytical team offers our clients a comprehensive range of state-of-the-art bioanalytical services including:

Analysis in Chemistry

• Isotope purity determination.

• Residual solvent determination in new chemical entities.

Analysis in DMPK

• Bioanalysis of in-vivo pharmacokinetic (PK) samples from different matrices, such as plasma and tissues.

• Bioanalysis with well-established procedures for all routine in-vitro ADME studies, such as plasma binding, permeability assays, metabolic stability and solubility.

• Bioanalysis of small, volatile or hydrophilic compounds using UPLC-MS/MS and GC-MS.

Analysis in Protein Science

• Targeted protein quantification including therapeutic biologics and biomarkers.

• Protein characterization including protein MW determination.

Discovery Biology Services…

As a Chemistry R&D company mainly focusing on APIs development, PHARMA INVENTOR INC., has continuous investment into bench-side Discovery Biology capabilities and expertise tailored to small molecule therapeutic projects…

 In-Vitro Biology

 Drug Metabolism and Pharmacokinetics (DMPK)

 Non-GLP Bioanalysis

 In-Vivo Pharmacology Studies

 Pharmaceutical Microbiology Testing

 Toxicology

We offer a comprehensive service that brings together all

End to End Patent Lifecycle Management

Proven Discovery Track Record...

A Novel Synthesis of a Triazolesulfonyl Chloride as a Precursor for GlyT-1 Inhibitors

Kashinath Sadalapure etal., , Discovery R&D, AMRI, 26 Corporate Circle, Albany, NY.

UK-Singapore Symposium on Contemporary Strategies and Practices in Medicinal Chemistry, 8 September 2011, Biopolis, Singapore

DD-Hydantoin recreational water treatment

Case Studies

Case study #1: Seed-stage start-up company

• Private Investor

• No science background

• Short timelines

Developed novel dug compounds

• Fast results & IP position

• Going to clinical

FFS and FTE Services

Each R&D project has different challenges and PHARMA INVENTOR INC. designs the project depending on the level of complexity utilizing either a fee for service (FFS) or a research-based full time equivalent (FTE) approach.

Fee For Service (FFS)

FFS chemistry R&D services approach is chosen depending on the specific needs of each individual project. FFS approach is usually suitable when a project has strong precedent or literature background without the need for extensive development.

Full Time Equivalent (FTE)

For technically more challenging and research-intensive chemistry R&D projects, FTE approach is highly recommended. FTE works very well for dedicated R&D projects and/or for the resolution of complexity/challenging chemistry problems. We can allocate specific team(s) of either one or more scientists with excellent expertise in your field to work on your project.

Pre-Clinical Clinical Phases 1, 2 and 3 Market

SR&ED Benefits: FTE vs FFS

Recognition by Life Sciences Communities

Turn static files into dynamic content formats.

Create a flipbook
Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.
Corporate Presentation - Pharma Inventor Inc. by pharmainventor - Issuu