Metoprolol – A Beta Blocker Drug Beta-adrenergic blocking agents are the class of medications that reduce your blood pressure and help to manage abnormal heart rhythms. These drugs work by blocking the effects of adrenaline, the hormone that triggers the body's fight-or-flight response when the person is stressed. Metoprolol is one such drug of this class that helps in the treatment of angina, high blood pressure, and heart failure. First made in 1969, Metoprolol is listed on the World Health Organization's List of Essential Medicines, as the most important medications needed in a basic health system. Structurally, Metoprolol contains a stereo center and exists as a racemic mixture of (R) and (S) enantiomer. Several achiral and chiral, impurities are associated with the synthesis of Metoprolol in the form of degradants, intermediates, and metabolites. Pharmaffiliates Analytics and Synthetics P. Ltd. have been able to perform impurity profiling for over 15 impurities associated with beta-blocker drug Metoprolol Succinate. Pharmaffiliates is one of the leading integrated CRO which deals with the Custom synthesis of Reference standards, Impurities, Metabolites, Deuterated compounds and Phyto standards. We also offer our expertise in providing services like Analytical research, Stability studies, Formulation & Development, Quality assurance and Regulatory Services. Pharmaffiliates has a huge database of reference standards for over 10,000 products and all the reference materials are provided in pack sizes of 25mg and 50mg with over 98% purity. Customized pack sizes are also available as per customer’s requirement. Following is the list of Metoprolol Succinate impurities available at Pharmaffiliates –
Pharmacopeial reference
BP
Name of the impurity
Product Code
CAS No.
Metoprolol Impurity A
PA 13 36010
109632-08-8
Metoprolol Impurity B
PA 13 36020
56718-71-9
Metoprolol Impurity C
PA 13 36030
29122-74-5
Metoprolol Impurity C (Maleate Salt)
PA 13 36031
NA
Metoprolol Impurity D
PA 13 36040
62572-90-1
Metoprolol Impurity E
PA 13 36050
163685-38-9
Metoprolol Impurity F
PA 13 36060
7695-63-8