Which Flea and Tick Treatment To Choose? Oral Vs. Topical Treatment Previously every pet parent used to struggle with one problem and that is, “Which topical flea and tick treatment to choose?” But after the advancement in the healthcare field, nowadays there is one more question that most pet parents ask and that is,” Which flea and tick treatment to choose, oral or topical?” You also might be one of those pet parents who is confused as to which treatment to choose to ensure a complete flea and tick protection? Don’t be confused, just refer to the comparison between oral and topical treatment given below and choose whichever suits you and your pet.