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Research b

Report 2016 Workforce Health Population Health and Integrated Care Patient Safety Innovative Technology and Therapies

Research Activity 2015/16

56 83 Publications

Projects considered for approval

96 20 Abstracts submitted for Celebrating Research 2015

Multisite projects approved to commence at Peninsula Health

Contents Introduction




Message from the Professor of Medicine


Our Research Vision


Feature Stories


Workforce Health


Population Health and Integrated Care


Patient Safety


Aged Care and Chronic Disease Management


Innovative Technology and Therapies


Commercially Sponsored and Collaborative Clinical Trials


Person Centred Care


Research Governance






Celebrating Research


Peninsula Health Research Report 2016


to the 2016 Peninsula Health Research Report. This year we are sharing stories about our research in each of the seven priority areas defined in our Research Strategic Plan. Our feature stories profile the cutting-edge research being done at Peninsula Health to change lives. The Cardiology team is breaking new ground in cardiovascular health, our allied health team is looking at ways to reduce workplace injuries, and we are trialling new uses for existing drugs and therapies.

This small snapshot of our research activity is intended to inspire and excite. I hope you find this Report interesting as it celebrates the breadth and commitment of our many researchers.

At Peninsula Health, our research enhances patient care, challenges clinical practice and promotes innovative healthcare delivery. Clinicians from all fields – medicine, nursing and allied health – are involved in research – all with the aim of improving the care we provide to our patients. Our research priorities reflect the unique needs of our community and will improve care and patient outcomes now and into the future. Now is an exciting time for research and clinical innovation at Peninsula Health, as we take a lead role in transforming healthcare delivery across our region.

Ms Sue Williams Chief Executive Officer



Peninsula Health Research Report 2016

Message from the Professor of Medicine Welcome to our 2016 Research Report – which highlights the exciting research and discovery being undertaken at Peninsula Health. As the inaugural Professor of Medicine, my role is to shape, support and drive the research agenda within Peninsula Health and our region over the next five years. Since commencing in my role in September, I have been impressed with the breadth of research being carried out and the talent and commitment of the researchers involved in these studies. Peninsula Health is already highly respected as a teaching and research facility, and the gains in research performance over the last few years reinforces that position, both for Peninsula Health and for the many thousands of patients and families who rely on us for cutting-edge and effective healthcare.

I will be working to create structures and processes that will enable high-quality research at Peninsula Health. There will be strong links developed with Monash University and its partner organisations that will substantially enhance our research capacity. I am excited and honoured to be the inaugural Professor of Medicine at Peninsula Health, and I look forward to working with our many researchers to find innovative solutions to the healthcare needs of our region. Finally, I would like to commend and congratulate everyone involved in research across Peninsula Health for another year of excellent work.

The Mornington Peninsula’s ageing population will provide plenty of challenges for healthcare over the next quarter of a century. The key goal of our research vision is to generate contemporary evidence to guide effective clinical care for our local community. The next ten years will deliver some significant progress in strategic research directions here on the Peninsula. By 2025, Peninsula Health is hoping to make significant advances in a number of areas, and my team and I hope to play a key part in achieving this.

Velandai Srikanth

Professor of Medicine

Peninsula Health Research Report 2016

Our Research Vision At Peninsula Health, we foster research that enhances patient care, challenges clinical practice and promotes innovative healthcare delivery. Clinicians from all fields – medicine, nursing and allied health – are involved in research at Peninsula Health – all with the aim of improving the care we provide to our patients. Our research priorities reflect the unique needs of our community and will improve care now and for the future.

Our Vision Our research vision is to embed a culture of innovation, evaluation and translation of research into practice across the whole health service; to support and mentor emerging researchers; to provide research leadership in integrated care of our ageing population; and to undertake collaborative research in many other areas of research strength.

Our achievements during 2016 • The Research and Academic Committee (a committee of the Board) was established during the year to help drive research practice at Peninsula Health. The Committee is chaired by Peninsula Health Board Director, Professor Henry Ekert AM. A community representative is also being sought for the Committee. • Professor Velandai Srikanth commenced in his role as the inaugural Professor of Medicine in September. His initial priorities will be to map the adjunct academic positions and research activity at Peninsula Health. • Architects have been appointed and planning is well underway for the new Academic Precinct.

• Peninsula Health is also now a member of Monash Partners. In March 2015 Monash Partners was recognised by the National Health and Medical Research Council as one of only four Advanced Health Research and Translation Centres in Australia. Monash Partners provides the foundations for borderless clinical care and translational research to be available across an immediate catchment population of 2.8 million people. • The inclusion of a multi-centre trial (The Nephro-Protective Trial) undertaken at Peninsula Health, in the National Health and Medical Research Council (NHMRC) ‘10 of the Best Research Projects’ publication. Congratulations to Professor John Botha and Associate Professor Andrew Davies as the project collaborators.

Research priorities for our region: • Person Centred Care • Innovative Technology and Therapies • Commercially Sponsored and Collaborative Clinical Trials • Population Health and Integrated Care • Aged Care and Chronic Disease Management • Patient Safety • Workforce Health


Workforce Health

Putting Your Back Into Preventative Healthcare Back pain is a common problem across many industries, but in Allied Health it can be particularly debilitating. Lower back pain is the bane of life for many adults, and especially those who work in health. Despite the high number of injuries, there has been little research on full day lumbar movement to identify ‘at risk’ behaviours or activities. Allied Health professionals, as well as surgeons and surgical trainees, are among those who are susceptible to repetitive strain injury.

Peninsula Health Research Report 2016

Peninsula Health and Monash University researchers, Dr Cylie Williams and Dr KellyAnn Bowles, are looking at the problem to help drive change in the sector. “There’s a lot of money spent on Workcover and injuries that relate to an accident such as slipping over,” says Dr Williams. “But then there’s repetitive strain injuries that result from performing a movement over and over again that cause pain or changes the way you move in a way that can cause musculoskeletal challenges.” “What we don’t know though is: who are the workers most at risk? Are there professions who are more at risk than others? Do they perform certain movements that put them more at risk?” Dr Williams and Dr Bowles are using a wireless sensor called ViMove to track back movement in key workers. The ViMove movement sensors are attached to the person’s lower back in three separate positions during a working day. The sensors then record data at 20 frames per second, measuring muscle activation, and also the movement of that posture in real time. The data calculates the time spent standing, sitting, or walking, as well as how often they sit in slouched position, flex forward, extend backwards, and the number of times they hold those positions for sustained periods. “One of the things we think is related to back pain is static postures. ViMove helps us see how much people hold those postures,” Dr Williams adds. The researchers are also looking at surgeons, as it is unknown if back pain is also common among this group.

Peninsula Health and Monash University researchers, Dr Cylie Williams (R) and Dr Kelly-Ann Bowles (L)

“We have also used the ViMove on surgeons to see what they are doing during surgery. One participant held the same static posture for 82 minutes.”

“One participant held the same static posture for 82 minutes” “All of us know someone who’s been hurt at work. This will give us better information to help train our students in better postures,” says Dr Williams. “We can determine which postures and movements will potentially give clinicians problems down the track, and hopefully we can have a preventative role.”



Peninsula Health Research Report 2016

Population Health and Integrated Care

Public Health Practitioner and Alcohol and Other Drugs Project Manager, Kirsty Morgan

Researching Alcohol and Drug Problems in the Local Community Public Health Practitioner and AOD (alcohol and other drugs) Project Manager, Kirsty Morgan, is working with the local community to find solutions to some of Frankston’s complex social problems.

Peninsula Health Research Report 2016

Alcohol and drugs are two of the most high-profile problems associated with Frankston. As part of the State Government’s $63 million Frankston Train Station Precinct redevelopment planning, a taskforce was appointed to make recommendations to help respond to ongoing concerns about alcohol and other drug (AOD) issues in the area. Kirsty is leading a study to identify trends in the Young Street precinct and the Frankston Mornington Peninsula area as a whole. “There was a lack of understanding about what was really going on in Young Street, in terms of alcohol and drug issues in the Train Station Precinct,” says Kirsty. “The study provides an evidence base to understand what’s actually going on so we can start to address the issues.” Stakeholders from across the Peninsula were involved, including local traders and business owners, drug treatment and healthcare providers, Victoria Police, and drug users themselves. “The population of injecting drug users isn’t significantly increasing but the mortality rate is, which indicates the need for harm reduction interventions and better primary healthcare,” says Kirsty. The study found that alcohol is still the biggest contributor to harm, although interventions have reduced the public nature of that drinking in Young Street. “We have found that an integrated health and community service hub in Frankston would greatly improve the delivery of primary healthcare services to vulnerable populations including people with alcohol and drug dependencies,” adds Kirsty. “We also found that we have a high presence of disengaged young people, who we know are at higher risk of developing alcohol and drug dependency, so we need to do some early intervention.” The study will help the State Government, local councils and health providers form long-term sustainable responses to the AOD problems at the Train Station Precinct and across the Peninsula.

The findings are concerning, but provide a firm basis for action Since 2014, there has been an increase1 in drug offences and presentations of harms in relation to crystal methamphetamine (ice) use, which is no surprise to many local residents. Interestingly though, the study found that pharmaceutical drugs have been responsible for more overdose deaths than illegal drugs, which is often not recognised.

1. C  rime Statistics Agency data shows there were 510 drug offences recorded in the area in 2012 but by 2016 it had jumped up to 1,114. Source: Crime Statistics Agency


PeninsulaPeninsula Health’s Health Dr 8Kim Wong and DrReport Minh Huan Research 2016Dang

Patient Safety

Peninsula Health Research Report 2016

Can Compression Help Prevent IDH in Haemodialysis? That is the question Peninsula Health’s Dr Kim Wong and Dr Minh Huan Dang are seeking to answer. The aim of Dr Wong and Dr Dang’s research was relatively simple in its approach to a highly complex medical problem. Would pneumatic compression devices (PCD) help in the prevention of Intradialytic Hypotension (IDH) in high-risk haemodialysis patients, when compared to standard care?

IDH is broadly defined as a significant decrease in systolic blood pressure, or a similar drop in mean arterial blood pressure. Symptoms include abdominal discomfort, nausea, vomiting, muscle cramps, dizziness, fainting and anxiety. It is a major cause of serious illness and death in elderly patients undergoing haemodialysis and those with heart problems. Dr Wong and Dr Dang engaged in a two-period, 18-treatment session, randomised crossover trial, where patients at a high risk of IDH were asked to wear a compression bandage device during dialysis. Pneumatic compression devices (PCD) are well established in the treatment of deep vein thrombosis. In these cases, PCDs are known to increase blood flow in the lower limbs, and increase venous return. “But there is a paucity of evidence regarding the use of PCDs in the prevention of IDH,” says Dr Dang. “We wanted to investigate whether a PCD could prevent venous blood pooling in the lower limbs of haemodialysis patients, thus supporting central blood volume and improving haemodynamic stability.” “The initial primary outcome was encouraging in that the incidence of IDH dropped marginally, but the secondary results were not as clear cut.” The randomised two groups of 16 patients showed no statistically significant difference in the rate of IDH, when an interim analysis halfway through the study was completed. This interim analysis showed that PCD has no noticeable effect on IDH; and while the completed data analysis cannot be compiled until the study is completed, it seems that the PCD trial will have a negative result. "An unintended interesting positive patient-benefit did occur in the trial though", Dr Dang explains.

“IDH is a relatively common problem, occurring in 20 to 30 per cent of haemodialysis patients, but it's hard to manage and its pathogenesis is poorly understood,” says Dr Dang.

“We were interested to note that during the fixing of the compression device and subsequent procedure, many patients commented that the massage-effect was extremely pleasant, and took their mind away from the actual medical process.” “This diversionary health benefit is certainly worth noting when we compile the final report.” The final study report is likely to be published in late 2016.



Peninsula Health Research Report 2016

Aged Care and Chronic Disease Management Peninsula Health Registrar in Geriatric Medicine, Dr Angelo Navaratne

Managing In-Hospital Falls – Are Sedatives and Anticholinergics the Problem? Falls in-hospital continue to be a significant and growing problem, especially among elderly patients. Peninsula Health Registrar in Geriatric Medicine, Dr Angelo Navaratne, is examining the relationship between the use of medications with sedative and anticholinergic properties and falls in-hospital.

Peninsula Health Research Report 2016

“More than one-third of elderly adults in the community fall in each year,” says Dr Navaratne. Falls related to acute care for elderly patients in Australia is estimated to cost more than $600 million every year, which equates to around $6,500 per fall. Some recent studies have shown a link between in-hospital falls in the elderly and the multiple medications that they are prescribed to address often multiple co-morbidities. “Medications commonly implicated in falls are sedatives, anticholinergics, antihypertensive medications and Parkinson’s medications, amongst others,” explains Dr Navaratne. Recent studies have shown a strong correlation between a high DBI score and in-hospital falls in elderly patients – however only a handful of studies have investigated this and none in a Geriatric Evaluation and Management Unit (GEM). Dr Navaratne’s study looked at the link between a high DBI and in-hospital falls at Peninsula Health’s Mornington Centre. The 18-month study had 254 patients enrolled – of the 51 participants who fell during the study period, the average age was 81.9 years and 57 per cent were female. A higher DBI score and visual impairment were significantly more prevalent among those who fell compared to those who did not fall. “There is a strong association between falls and a high DBI score among elderly patients in the GEM unit,” explains Dr Navaratne. “The study shows a significant link between falls and the patient’s exposure to medications with sedative or anticholinergic properties.” “As such, there is now software available to assess the DBI score of each patient at the time of admission, which could be an important preventative measure if they are already known for a high risk of falls,” says Dr Navaratne. “This may prompt health professionals in dose reduction, as well as weaning off some of these medications,” he adds.

Drug Burden Index The Drug Burden Index (DBI) is commonly used to measure a patient’s exposure to anticholinergic and sedatives. A high DBI score means a patient is receiving a high dose of a single medication or multiple medications with sedative and anticholinergic properties.

“All these considerations may improve safety, the quality of care, and the wellbeing of patients in GEM units, including at our own Mornington Centre.”


AssociatePeninsula ProfessorHealth David Langton, Peninsula Health 12 Director of Thoracic Medicine Research Report 2016

Innovative Technology and Therapies

Breakthrough in Treatment for Severe Asthma New asthma treatment showing real promise for long-term sufferers.

Peninsula Health Research Report 2016

Bronchial thermoplasty is a relatively new surgical procedure that has been shown to reduce the effects of asthma attacks on chronic and severe asthma sufferers, for whom traditional medications do not work. The procedure is only available at a few sites in Australia, and Frankston Hospital is currently the only site in Victoria. Associate Professor David Langton, Peninsula Health Director of Thoracic Medicine, has been performing the surgery for more than two years. “For those patients suffering with bad asthma that remain symptomatic despite inhaled corticosteroids and long acting bronchodilators, this treatment has now been shown to be both safe and effective,” says Dr Langton. The bronchial thermoplasty procedure involves inserting a small tube down the patient’s airway and into their lungs. A heat probe is then used to treat the muscles that cause bronchospasm. “The treatment is painless and is delivered under general anaesthetic. Three treatment sessions are required to treat all parts of the lung,” says Dr Langton. “By weakening these muscles, they no longer cause wheezing and asthma attacks.” The review of all bronchial thermoplasty cases from June 2014 to December 2015 was conducted at three Australian teaching hospitals. Twenty cases were identified with 13 men and seven women included in the review. Within the group, 18 patients had never smoked, and two were classed as ex-smokers. All of the members of the review group had been prescribed high doses of corticosteroids, and all were using long-acting beta agonists and longacting muscarinic antagonists.

“Out of the group of 20 patients over 18 months, only three failed to show any improvement” Out of the group of 20 patients over 18 months of procedures, only three failed to show any improvement with the treatment. “Despite the severity of asthma in this group, serious adverse events were uncommon, and only occurred in one patient who required hospitalisation beyond the planned treatmentrelated admission,” adds Dr Langton. “Her subsequent clinical outcome has been excellent.” This study demonstrates that bronchial thermoplasty is a safe and effective treatment for patients with severe asthma.



Peninsula Health Research Report 2016

Commercially Sponsored and Collaborative Clinical Trials Peninsula Health is currently involved in a number of commercially sponsored and collaborative clinical trials, looking at some of the key illnesses affecting people across the Mornington Peninsula. Dr Layland is one of a small number of cardiologists in the world who have inserted this new absorbable stent. A stent is a small mesh tube used to treat narrow arteries in the heart. Traditionally, a metal stent is inserted in an artery in patients undergoing a coronary angioplasty – a procedure that opens blocked arteries and restores normal blood flow to the heart. “The absorbable stent is similar to the traditional version but it has the benefit of dissolving after the device has served its purpose,” Dr Layland explains. “This is a revolutionary advance in the treatment of coronary artery disease,” he adds.

Associate Professor Jamie Layland

Absorbable Stents a Game Changer In July 2016, Cardiologist Associate Professor Jamie Layland inserted an absorbable heart stent in a patient at Peninsula Health – a breakthrough first for the health service. The Peninsula Health researchers, Dr Layland along with cardiologist Dr Robert Lew, are part of a worldwide team investigating the use of absorbable stents in patients with heart disease.

“The absorbable stent will open an arterial blockage just like a metallic stent, but then it dissolves over time, allowing the artery to return to a more natural state.” The radical new stent dissolves in around two years, compared with traditional metal stents, which stay in a patient for life.

“This is a revolutionary advance in the treatment of coronary artery disease”

Peninsula Health Research Report 2016

Exploring New Medication Use for Blood Cancers

Associate Professor John Catalano is undertaking clinical trials at Peninsula Health for patients with haematological malignancies. The trials are using a drug called Keytruda (pembrolizumab). “Keytruda is a drug that has been approved for use in treating advanced melanoma and we are now keen to trial it for other conditions,” says Dr Catalano. Australia is the first country in the world to register Keytruda for the first line treatment of unresectable or metastatic melanoma in adults. “These trials at Peninsula Health will help to explore whether the drug’s use can be extended beyond its known capabilities,” explains Dr Catalano.

Associate Professor John Catalano

Improving Quality Of Life for Critically Ill Patients Associate Professor Andrew Davies is leading a study in conjunction with the ANZICS Clinical Trials Group investigating the amount of nutrition patients should be administered in intensive care. Nutrition therapy is an essential standard of care for all ICU patients who are mechanically ventilated, as they are unable to eat for themselves.

The three current trials include patients with hematologic malignancies, those with refractory or relapsed and refractory Multiple Myeloma, and those with newly diagnosed and treatment naïve Multiple Myeloma.

and the relatively high mortality following ICU admission,” Dr Davies adds. Our recently published pilot study clearly achieved all the key criteria, which, for a pharmaceutical product would lead to a phase III trial. A definitive study must now be completed to establish whether 90-day survival and functional outcomes following critical illness could be improved by increased calorie intake.

Enteral nutrition via a nasogastric tube is usually started within 24 hours of ICU admission, but standard practice usually results in around a 60% intake of the recommended calorie amount. In this study the investigators are testing whether giving a higher concentration of calories in the same volume of nutrition will be any better. “Previous trials support the concept that optimising nutrition in the critically ill will improve outcomes, however, the evidence is limited, inconclusive and generally of low quality,” explains Dr Davies. “It is extraordinary that there is not better evidence to inform nutrition management in critically ill patients given the frequency of the intervention

Associate Professor Andrew Davies



Peninsula Health Research Report 2016

Associate Professor Sean Jespersen and Dr Lisa Brophy

Person Centred Care

Evaluating Y-PARC Peninsula Health’s Clinical Director of Mental Health Services, Associate Professor Sean Jespersen, in conjunction with Dr Lisa Brophy from The University of Melbourne and Mind Australia, is leading a study into the effectiveness of the Y-PARC (Youth Prevention and Recovery Care) in Frankston.

Peninsula Health Research Report 2016

Y-PARC is a partnership of Peninsula Health, MIND Australia and Mentis Assist to provide short-term mental health residential support for young people aged 16 to 25.

Associate Professor Sean Jespersen

“The model of care is based on a developmental and holistic approach to the young person’s recovery,” says Dr Jespersen. “It provides clinical and mental health support services, links to services in the community, and involvement and engagement of family members in the young person’s recovery.” The evaluation will assess whether Y-PARC is meeting its objectives and identify ways to improve the quality and effectiveness of the program. “It’s vital we evaluate whether the Y-PARC is contributing positively to the ongoing wellbeing and recovery of its clients,” explains Dr Jespersen. “We are keen to know whether the Y-PARC is providing treatment and care that is consistent with evidence of effectiveness, as well as the accepted principles of Recovery Focussed Care”. “We are also keen to understand whether carers and family members are recognised, valued and supported for the vital role they play in assessment, treatment and recovery”. It is hoped the study will identify ways to improve the provision of therapeutic recovery focussed treatment, and to help the sector understand the impact of Y-PARC on the client’s mental health status. “Importantly, the evaluation will also look at whether Y-PARC is helping to reduce demand at other acute medical and mental health services,” says Dr Jespersen.

What is Y-PARC? • Youth-focussed residential mental health care. • Short-term transitional recovery care and support.

What does Y-PARC do? • Promotes and supports strong family and carer engagement. • Enables earlier discharge from an acute setting by providing an intensive, safe and supportive community-based mental health program.



Peninsula Health Research Report 2016

Members of Research Committees 2015/16 Research and Academic Committee

Ms Sally Church – Healthcare Professional

The strategic objectives of the Research and Academic Committee are to:

Ms Julie Grant – Healthcare Professional

• Foster excellence in research and innovation at Peninsula Health to improve the health outcomes for our community • Enhance Peninsula Health’s ability to successfully compete for health research funding • Foster the dissemination of research findings through publication in peer-reviewed journals. Professor Henry Ekert AM (Chair) Dr Nathan Pinskier (Deputy Chair) Professor John Botha Mr Nigel Broughton Ms Lee-Anne Clavarino Professor Terry Haines Dr Fergus Kerr Associate Professor Virginia Plummer Professor Velandai Srikanth Dr Cylie Williams

Human Research Ethics Committee The Human Research Ethics Committee (HREC) reports to the Board of Directors through the Research and Academic Committee. The role of the HREC is to: • Ensure the design and conduct of any human research that it reviews within the scope of its responsibilities conforms with the National Statement on Ethical Conduct in Human Research (NHMRC, ARC, UA, 2007) (National Statement) and other relevant national codes of human research ethics and also with the ethical standards to which Peninsula Health is committed. • Ensure that participants in any human research that the HREC reviews and approves are accorded the respect and protection that is due to them. • Facilitate and foster human research that is of benefit to Australian communities. • Ensure that any decision it makes complies with relevant Victorian and Australian laws. Professor Henry Ekert AM – Board Director (Chair) Associate Professor Virginia Plummer – Researcher (Chair) Dr Fergus Kerr – Executive Sponsor Professor John Botha – Director of Research Dr Stephen Bright – Healthcare Professional

Ms Jan deClifford – Senior Pharmacist Ms Joanna Green – Lawyer Dr Debra Griffiths – Researcher Dr Dilinie Herbert­– Ethicist Ms Alice Irving – Laywoman Mr Richard Ivice – Layman Associate Professor Terry Loughnan – Researcher Ms Mariangela Prib – Chaplain Mr Adrian Stone – Lawyer Associate Professor Ravi Tiruvoipati – Researcher Dr Ashley Webb – Researcher Dr Cylie Williams – Researcher

Low Risk Research Subcommittee Associate Professor Virginia Plummer (Chair) – Associate Professor Nursing Research Mr Nigel Broughton – Deputy Director of Research, Director of Orthopaedic Research Mr Sean Chinnathumby – Clinical Research Nurse Ms Lee-Anne Clavarino – Manager Office for Research Ms Alison Lunt – Occupational Therapist Dr George Miller – Plastic Surgery Registrar Mr Peter Raphael – Community Member Associate Professor Warren Rozen – Plastic Surgeon Mr Michael Wang – Physiotherapist Ms Sharon White – Operations Director Women’s, Children’s and Adolescent Health, Director Quality and Innovation

Scientific Advisory Subcommittee Professor John Botha – Director of Research, Director of Intensive Care Mr Nigel Broughton – Deputy Director of Research, Director of Orthopaedic Research Associate Professor Ernie Butler – Head of Neurology Associate Professor Miodrag Dodic – Year 4c and Research Coordinator, Peninsula Clinical School Dr Sam Leong – Consultant Anaesthetist Associate Professor Virginia Plummer – Associate Professor Nursing Research Dr Cylie Williams – Community Health and Allied Health Research Lead

Peninsula Health Research Report 2016


Projects Approved to Commence at Peninsula Health Reviewed Through the Streamlined Ethical Review System in Victoria or National Mutual Acceptance • Reducing the impact of aphasia in stroke patients and their caregivers. PI: Penni Drysdale

• An open-label, long-term, safety and efficacy study of intranasal esketamine in treatment-resistant depression. PI: Dr Jennifer Grunfeld

• A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of dupilumab in patients with persistent asthma. PI: Associate Professor David Langton

• A phase III study of lenalidomide and low-dose dexamethasone with or without pembrolizumab (MK3475) in newly diagnosed and treatment naïve multiple myeloma. PI: Associate Professor John Catalano

• An epidemiological study of rapid sequence intubation in out-of-hospital non-traumatic brain injuries. PI: Associate Professor Pam Rosengarten

• A phase II randomised, double-blind, placebo-controlled study of the efficacy, safety and tolerability of oral NP202 in adults who have left ventricular systolic dysfunction following myocardial infarction. PI: Associate Professor Jamie Layland

• A prospective, multicentre, randomised study to assess the impact of low-dose colchicine on long-term cardiovascular outcomes in patients presenting with acute coronary syndromes. PI: Associate Professor Jamie Layland • A randomized, multicenter, open-label, non-inferiority, phase 3 study of ACP-196 versus ibrutinib in previously treated subjects with high risk chronic lymphocytic leukemia. PI: Dr Patricia Walker • Psychosocial intervention using online resources to promote personal recovery in users of mental health services: Service. PI: Fiona Reed • Psychosocial intervention using online resources to promote personal recovery in users of mental health services: Therapy PI: Fiona Reed • A multicentre, randomized, parallel group, phase III safety extension study to evaluate the safety and tolerability of benralizumab (MEDI-563) in asthmatic adults and adolescents on inhaled corticosteroid plus long-acting ß2 agonist. PI: Associate Professor David Langton • A randomized, multicenter, open-label, 3 arm phase 3 study of obinutuzumab in combination with chlorambucil, ACP-196 in combination with obinutuzumab, and ACP-196 monotherapy in subjects with previously untreated chronic lymphocytic leukemia. PI: Dr Patricia Walker • Efficacy and safety of SAR156597 in the treatment of Idiopathic Pulmonary Fibrosis (IPF): A randomized, double-blind, placebocontrolled, 52-week dose ranging study. PI: Associate Professor David Langton

• Prospective, multicentre, international registry of male and female patients newly diagnosed with atrial fibrillation and treated with rivaroxaban. PI: Associate Professor Jamie Layland • Fully absorbable scaffold feasibility study. PI: Associate Professor Jamie Layland • A phase 3, placebo-controlled, randomized, double-blind, multi- center study of LJPC-501 in patients with catecholamineresistant hypotension. PI: Associate Professor Andrew Davies • The Augmented versus Routine approach to Giving Energy Trial: A randomised controlled trial. PI: Associate Professor Andrew Davies • Victorian Cardiac Outcomes Registry (Heart Failure Snapshot). PI: Dr Philip Carrillo • A phase III study of pomalidomide and low dose dexamethasone with or without pembrolizumab (MK3475) in refractory or relapsed and refractory multiple myeloma (rrMM). PI: Associate Professor John Catalano • Exploration of a patient’s experience of using an iPad in an inpatient palliative care unit. PI: Tarah Baker

Projects Considered by the Human Research Ethics Committee • A prospective randomised study comparing the efficacy of two different concentrations of intranasal fentanyl: the standard formulation (50mcg/mL) and the concentrated formulation (300mcg/mL) in adults presenting to Frankston Hospital Emergency Department (ED) with moderate to severe pain. PI: Associate Professor Pam Rosengarten

• A Rapid Situation Assessment to inform responses to alcohol and drug use across the FMP catchment. PI: Kirsty Morgan

• The effects on balance and falls in those with Parkinson's Disease: A comparison between land based, traditional aquatic and novel aquatic physiotherapy. PI: Fleur Terrens

• The effect of pneumatic compression devices on intradialytic hypotension. PI: Dr Kim Wong

• Can free nicotine replacement therapy (NRT) and a text support service increase smoking cessation before scheduled surgery? A randomised trial. PI: Dr Ashley Webb

• Using a smaller bronchoscope to improve the effectiveness of bronchial thermoplasty. PI: Associate Professor David Langton

• The acceptance and feasibility of a personal health monitoring device among patients with chronic conditions: a pilot study. PI: Professor Velandai Srikanth


Peninsula Health Research Report 2016

Projects considered by the Low Risk Research Subcommittee • Exploring the health and nutritional status of residents in Supported Residential Services (SRS). PI: Erin Farnbach • What is the self-reported attitude of staff to the introduction of a digital medical record system at Peninsula Health Community Health? PI: Iain Edwards • Nurse’s perceptions of the optimal frequency and type of rapid response training in the subacute hospital setting. PI: Tracy Pratt • Analysis of Emergency Department Information System (EDIS) on quality of care and information integrity. PI: Associate Professor Virginia Plummer • The additional cost of physiotherapy student under performance on clinical placements. PI: Dr Stephen Maloney, Haria Lambrou • Correlation between overnight oxygen saturations and sleep studies in patients with acute coronary syndromes. PI: Dr Gary Braun, Dr Sarah Gutman • The usefulness of mindfulness for newly registered nurses - a pilot study. PI: Rosie Wotherspoon • Evaluation of the Youth Prevention and Recovery Care Service (Y-PARC) - case file audit. PI: Dr Lisa Brophy, Associate Professor Sean Jespersen • Evaluation of the Youth Prevention and Recovery Care Service (Y-PARC) – qualitative interviews. PI: Dr Lisa Brophy, Associate Professor Sean Jespersen • Health literacy of people attending emergency departments for primary care-type presentations. PI: Dr Alison Beauchamp • DeFining Lumbar Extension, FleXion And Rotation in the workplace (FLEXAR). PI: Dr Kelly-Ann Bowles • End-of-life practices in intensive care units around the world. PI: Professor John Botha • Future directions for acute care nursing research: delphi study. PI: Associate Professor Virginia Plummer • Neurophysiological evaluation of healthy adults over 80 years old for obtaining normative sensory and motor response data. PI: Dr Kenae Nagao • Prevalence and patterns of mental health comorbidity among people accessing Australia’s first older adult-specific alcohol and other drug treatment service. PI: Dr Stephen Bright • 3D Printing of wrist pathologies – an educational tool for patients. PI: Associate Professor David Hunter-Smith • What were the outcomes for patients who had percutaneous drainage as a non-operative management for diverticular abscess? PI: Dr Senthilkumar Sundaramurthy

• Barriers and enablers to meeting the National Emergency Access Targets (NEAT) in the Emergency Department (ED): Perceptions of Emergency Nurses. PI: Susan Jackson • Identifying barriers to engagement in cancer rehabilitation. PI: Dr Cameron McLaren • The PEG tube decision: A retrospective audit of PEG insertions 2013 – 2016 and exploration of consumer satisfaction with the level of involvement in the decision making process. PI: Karman Liu • Advanced radiographic practice in image interpretation. PI: Beverley Pearce

Peninsula Health Research Report 2016

Quality assurance/Audit projects considered by Executive Sponsor Research • Analysis of subacute to acute hospital transfers, and the effects of structural change within the subacute service.

• Revision hip and knee arthroplasty: How many asymptomatic joints do we revise?

• The epidemiology of peritonsillar abscess (sepsis) in Frankston surrounds and the Mornington Peninsula.

• An overview of the use of high-flow oxygen therapy at a metropolitan Australian hospital.

• Exploring ICU handover using ISBARICU.

• Epidemiology and outcomes in alcohol and gallstone pancreatitis.

• Effectiveness of resuscitation documentation in newly admitted patients, their relevance to clinical status and outcome.

• Assessing the quality of discharge summary content at Peninsula Health using the SAIL - GP Feedback pilot study.

• Does femoral cortical thickness predict clinical mineral bone density?

• Rapid rule out of acute coronary syndrome.

• Optimising scalp flap geometry. • Mapping foot health in the residential aged care population. • Epidemiology of patients presenting to the Emergency Department of Frankston Hospital following acute drug overdose. • Single session therapy post discharge from the acute hospital setting. • Retrospective audit of current management of elective colorectal patients for comparison with the Enhanced Recovery After Surgery (ERAS) care pathway. • Compliance and outcome in a virtual clinic for long term followup of patients after hip and knee replacement: Part II. • Evaluation of the appropriateness of anti-glycaemic agents used in T2D: Are safety guidelines adhered to? • Renal ultrasound in acute kidney injury. • Predictors of the outcome of patients admitted to ICU with COPD. • Indications and use of systemic steroids in patients with sepsis in the Intensive Care Unit. • Evaluation of the safety and efficacy of extracorporeal carbon dioxide removal in the critically ill, using the Hemolung device. • Sedation assessment and management in ICU: an international comparative study. • Depot antipsychotic use in an aged psychiatry service. What agents are used, are they tolerated and do we monitor adequately for side-effects? • A retrospective, single-centre study of the impact of new gestational diabetes mellitus guidelines on usage of outpatient services, the requirement of insulin treatment and a cost analysis. • Impact of the introduction of AnchorFast devices on the incidence of oral pressure injuries in a metropolitan Australian intensive care unit. • Understanding the diabetic foot wound and occasions of service and separations within a podiatry service. • Are there different types of sensory profiles associated with idiopathic toe walking gait? • In-hospital falls among elderly patients and their exposure to medications with anticholinergic and sedative effects. • Patterns of nasal foreign body presentation in children from the Mornington Peninsula and Frankston surrounds, Victoria, Australia. • Use of the 4AT cognitive assessment tool by medical staff to assess for delirium. • Improving the identification and management of severe sepsis.

• Intensive v limited early correction of hyperglycaemia in critically ill patients with diabetic ketoacidosis. • Does lesion location in cases of confirmed Buruli ulcer suggest transmission by biting insects? A quantitative study. • Evaluating the effectiveness of situating an alcohol and other drug clinician in the mental health and homelessness team. • Audit of x-ray interpretation accuracy of Peninsula Health ED advanced musculoskeletal physiotherapists.



Peninsula Health Research Report 2016

Publications Ackerman, I.N., Bucknill, A., Page, R.S., Broughton, N.S., Roberts, C., Cavka, B., Shcoch, P. & Brand, C.A. (2016). Preferences for disease-related education and support among younger people with hip or knee osteoarthritis. Arthritis Care & Research. doi: 10.1002/acr.22950 Allsopp, B., Hunter-Smith, D.J., & Rozen, W.M. (2016). Vascularised or nonvascularised bone grafts: What is the evidence? Clinical Orthopaedics and Related Research, 474(5), 1319-1327. doi: 10.1007/s11999-016-4769-4 Al-Moteri, M., Plummer, V., Symmons, M., & Cooper, S. (2015). Training paradigms to enhance clinical observational skills in clinical practice: A scoping review. Journal of Nursing Education and Practice, 5(12). doi: 10.5430/jnep.v5n12p96 Al Thobaity, A., Williams, B., & Plummer V. (2016). A new scale for disaster nursing core competencies: Development and psychometric testing. Australasian Emergency Nursing Journal, 19(1), 11-19. doi: 10.1016/j.aenj.2015.12.001 Banakh, I. (2016). Prevalence of medication-related risk for falls and osteoporosis at a hospital network: A post-hoc analysis. International Journal of Orthopaedics, 3(2), 528-534. doi:.10.17554/j.issn.2311-5106.2016.03.158 Banakh, I., Lam, A., Tiruvoipati, R., Carney, I., & Botha, J. (2016). Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence-based review. Clinical Case Reports, 4(5), 486-490. doi: 10.1002/ccr3.549 Borkowski, D., McKinstry, C., Cotchett, M., Williams, C., & Haines, T. (2016). Research culture in allied health: A systematic review. Australian Journal of Primary Health. Advance online publication. doi: 10.1071/PY15122 Cabalag, M.S., Chae, M.P., Miller, G.S., Rozen, W.M., & Hunter-Smith, D.J. (2016). Use of three-dimensional printed “haptic” models for preoperative planning in an Australian plastic surgery unit. Australian and New Zealand Journal of Surgery. Advance online publication. doi: 10.1111/ans.13168 Cabalag, M.S., Rostek, M., Miller, G.S., Chae, M.P., Quinn, T., Rozen, W.M., & Hunter-Smith, D.J. (2016). Alloplastic adjuncts in breast reconstruction. Gland Surgery. 5(2), 158-173. doi: 10.3978/j.issn.2227-684X.2015.06.02 Chae, M.P., Hunter-Smith, D.J., & Rozen, W.M. (2016). Comparative study of software techniques for 3D mapping of perforators in deep inferior epigastric perforator flap planning. Gland Surgery. 5(2), 99-106. doi: 10.3978/j.issn.2227-684X.2015.06.03

Haji, K., Butler, E., & Royse, C. (2015). A case of chronic inflammatory demyelinating polyneuropathy with reversible alternating diaphragmatic paralysis: case study. Critical Ultrasound Journal, 7(16). doi: 10.1186/s13089-015-0033-5 Haji, K., Royse, A., Green, C., Botha, J., Canty, D., & Royse, C. (2016). Interpreting diaphragmatic movement with bedside imaging. Journal of Critical Care. Advance online publication. doi: 10.1016/j.jcrc.2016.03.006 Hale, N., Murphy, A.M., Adams, J.R., & Williams, C.M. (2016). Effect of a smokefree policy on staff attitudes and behaviours within an Australian metropolitan health service: a 3 year cross-sectional study. Australian Health Review. Advance online publication. doi: 10.1071/AH15159 Hoskins, W., Bingham, R., Joseph, S., Liew D., Love, D., Bucknill, A., Oppy A., & Griffin, X. (2015). Subtrochanteric fracture: The effect of cerclage wire on fracture reduction and outcome. Injury, 46(10), 1992-1995. doi: 10.1016/j.injury.2015.07.001 Hunter-Smith, D.J., Slattery, P.G., Rizzitelli, A., Hunter-Smith, S.R., Fairbank, S., Rozen, W.M., & Findlay, M.W. (2015). The dorsal triangular fibrocartilage of the metacarpophalangeal joint: A cadaveric study. Journal of Hand Surgery (American Volume), 40(7) 1410-1415. doi: 10.1016/j.jhsa.2015.03.019 Jackson, D., Bartl, D., Tong, D., & Layland, J. (2016). Bushfires, not to be taken light heartedly. Journal of Clinical and Experimental Cardiology, 7(3). doi:10.4172/2155-9880.1000426 James, A.M., Williams, C.M., & Haines T.P. (2016). Effectiveness of footwear and foot orthoses for calcaneal apophysitis: a 12-month factorial randomised trial. British Journal of Sports Medicine. Advance online publication. doi:10.1136/bjsports-2015-094986 James, A.M., Williams, C.M., & Haines T.P. (2016). Health related quality of life of children with calcaneal apophysitis: child & parent perceptions. Health and Quality of Life Outcomes, 14(95). doi: 10.1186/s12955-016-0497-4 Jamieson J., Tran V., & Mackenzie S. (2016). Gender equality in emergency medicine: Ignorance isn't bliss. Emergency Medicine Australasia, 28(3), 341-343. doi:10.1111/1742-6723.12595 Jespersen, S., Lawman, B., Reed, F., Hawke, K., Plummer, K., & Gaskin, C.J. (2016). The impact of integrating crisis teams into community mental health services on emergency department and inpatient demand. Psychiatric Quarterly, 87(4), 703-712. doi:10.1007/s11126-016-9420-8

Chae, M.P., Rozen, W.M., Spychal, R.T., & Hunter-Smith, D.J. (2016). Breast volumetric analysis for aesthetic planning in breast reconstruction: a literature review of techniques. Gland Surgery. 5(2), 212-226. doi: 10.3978/j.issn.2227-684X.2015.10.03

Katz, T.L., Hunter-Smith, D.J., & Rozen, W.M. (2016). Reverse second dorsal metacarpal artery vascularized bone flap for index distal bone loss: A case report. Microsurgery. 36(3), 250-253. doi: 10.1002/micr.22519

Chowdhry, M., Rozen, W.M., & Griffiths, M. (2016). Lymphatic mapping and preoperative imaging in the management of post-mastectomy lymphoedema. Gland Surgery, 5(2), 187-196. doi: 10.3978/j.issn.2227-684X.2015.11.06

Khalil, H., Chambers, H., Khalil, V., & Ang, C. (2016). The efficacy of Vitamin B for the management of diabetic peripheral neuropathy. Cochrane Database of Systematic Reviews, 6. doi:10.1002/14651858.CD012237

Cranage, S., Banwell, H., & Williams, C.M. (2016). Gait and Lower Limb Observation of Paediatrics (GALLOP): development of a consensus based paediatric podiatry and physiotherapy standardised recording proforma. Journal of Foot and Ankle Research, 9(8). doi: 10.1186/s13047-016-0139-4

Liu, F.F., Kong, L.M., Ng, S., Hunter-Smith, D.J., & Findlay, M.W. (2015). Massive primary melanoma without clinically detectable metastases. Australian and New Zealand Journal of Surgery, 85(9), 688-689. doi:10.1111/ans.12525

D'Cunha, C., Plakiotis, C., Macfarlane, S., Moss, F., Reddy, M., Singh, D., Tofler, D., & O'Connor, D.W. (2016). The clinical and service outcomes of unilateral and bilateral ECT electrode placements in Australian aged psychiatry services. Journal of ECT, 32(1), 44-8. doi: 10.1097/YCT.0000000000000268 Gao, W., Plummer, V., Williams, A. (2016). Perioperative nurses’ attitudes toward organ procurement: A systematic review. Journal of Clinical Nursing. Advance online publication. doi: 10.1111/jocn.13386 Griffiths, M., Chae, M.P., & Rozen, W.M. (2016). Indocyanine green-based fluorescent angiography in breast reconstruction. Gland Surgery, 5(2), 133-149. doi: 10.3978/j.issn.2227-684X.2016.02.01

MacKenzie, S., & Edmonds, M.J.R. (2015). Securing a consultant position as a new Fellow of the Australasian College for Emergency Medicine. Emergency Medicine Australasia, 27(6), 610-611. doi:10.1111/1742-6723.12511 Malik, G., McKenna, L., & Plummer, V. (2016). Facilitators and barriers to evidence based practice: perceptions of nurse educators, clinical coaches and nurse specialists from a descriptive study. Contemporary Nurse. Advance online publication. doi. 10.1080/10376178.2016.1188017 Marshall, S.D., Boden, E., & Serpell, J. (2015). The effect of routine reversal of neuromuscular blockade on adequacy of recurrent laryngeal nerve stimulation during thyroid surgery. Anaesthesia and Intensive Care, 43(4) 485-9.

Peninsula Health Research Report 2016

Morphet, J., Griffiths, D.L., Crawford, K., Williams, A., Jones, T., Berry, B., & Innes, K. (2016). Using trans professional care in the emergency department to reduce patient admissions: A retrospective audit of medical histories. Journal of Interprofessional Care, 30(2), 226-231. doi: 10.3109/13561820.2015.1115394

Stewart, J.A., Green, C., Stewart, J., & Tiruvoipati, R. (2016). Factors influencing quality of sleep among non-mechanically ventilated patients in the Intensive Care Unit. Australian Critical Care. Advance online publication. doi: 10.1016/j.aucc.2016.02.002

Morphet, J., Kent, B., Plummer, V., & Considine, J. (2015). The effect of transition to specialty practice programs on Australian emergency nurses’ professional development, recruitment and retention. Australasian Emergency Nursing Journal. 18(4), 204-11. doi: 10.1016/j.aenj.2015.08.001

Suryanto, Plummer, V., Copnell, B. (2016). Collaboration between nurses and physicians in an Indonesian Emergency Department. Australasian Emergency Nursing Journal, 19(2), 82-89. doi:10.1016/j.aenj.2016.04.001

Morphet, J., Kent, B., Plummer, V., Considine, J. (2015). Transition to specialty practice programs in Emergency Nursing. Australian Nursing and Midwifery Journal, 23(1).

Ting, J.W., Yue, B.Y., Tang, H.H., Rizzitelli, A., Shayan, R., Raiola, F., Rozen W.M., & Hunter-Smith, D.J. (2016). Emergency department presentations with mammalian bite injuries: risk factors for admission and surgery. Medical Journal of Australia, 204(3), 114-120. doi: 10.5694/mja15.00653

Morphet, J., Kent, B., Plummer, V., & Considine, J. (2016). Profiling nursing resources in Australian emergency departments. Australasian Emergency Nursing Journal, 19(1), 1-10. doi: 10.1016/j.aenj.2015.12.002

Tong, D.C., Wilson, A.M., & Layland, J. (2016). Novel risk factors for acute coronary syndromes and emerging therapies. International Journal of Cardiology. Advance online publication. doi: 10.1016/j.ijcard.2016.06.148

Morphet, J., Kent, B., Plummer, V., & Considine, J. (2016). Transition to specialty practice program characteristics and professional development outcomes. Nurse Education Today. Advance online publication. doi: 10.1016/j.nedt.2016.05.017

Tong, D.C., Wilson, A.M., & Layland, J. (2016). Colchicine in cardiovascular disease: an ancient drug with modern tricks. Heart. Advance online publication. doi: 10.1136/heartjnl-2015-309211

Ng, T.T., Soon D.S.C., & Mahanta, V. (2016). A tale of two anomalies: fourth branchial cleft cyst with thyroid hemiagenesis. Australian and New Zealand Journal of Surgery. Advance online publication. doi:10.1111/ans.13637

Toppi J.T., Trompf L., Smoll N.R., Lim V., Smith K., Findlay M.W., HunterSmith D.J. (2015). Dupuytren's contracture: an analysis of outcomes of percutaneous needle fasciotomy versus open fasciectomy. Australian and New Zealand Journal of Surgery, 85(9), 639-43. doi: 10.1111/ans.12513

Ng, T.T. (2016). 20 ways of removing a nasal foreign body in the emergency department. Otorhinolaryngology - Head and Neck Surgery, 1(1), 2-6. doi: 10.15761/OHNS.1000102 Niumsawatt, V., Chow, K., Shen, X.Y., Rozen, W.M., & Hunter-Smith, D.J. (2016). The Pfannenstiel scar and its implications in DIEP flap harvest: a clinical anatomic study. European Journal of Plastic Surgery, 39(1), 41-48. doi: 10.1007/s00238-015-1176-0 Quinn, T.T., Miller, G.S., Rostek, M., Cabalag, M.S., Rozen, W.M., & HunterSmith, D.J. (2016). Prosthetic breast reconstruction: indications and update. Gland Surgery, 5(2), 174-186. doi: 10.3978/j.issn.2227-684X.2015.07.01 Reade, M.C., Eastwood, G.M., Bellomo, R., Bailey, M., Bersten, A., Cheung, B., & Davies, A. (2016). Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomised clinical trial. JAMA, 315(14), 1460-1468. doi: 10.1001/jama.2016.2707 Ridgeon, E., Bellomo, R., Myburgh, J., Saxena, M., Weatherall, M., Jahan, R., Arawwawala, D., Bell, S., Butt, W., Camsooksai, J., Carle, C., Cheng, A., Cirstea, E., Cohen, J., Cranshaw, J., Delaney, A., Eastwood, G., Eliott, S., Franke, U., Gantner, D., Green, C.,...& Young, P. (2016). Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability. Critical Care and Resuscitation, 18(1), 50-54. Rozen, W.M., & Hunter-Smith, D.J. (2016). New technology in breast reconstruction. Gland Surgery, 5(2), 86-87. doi: 10.3978/j.issn.2227-684X.2015.05.16 Sathianathan, K., Tiruvoipati, R., & Vij, S. (2016). Prognostic factors associated with hospital survival in comatose survivors of cardiac arrest. World Journal of Critical Care Medicine, 5(1), 103-110. doi:10.5492/wjccm.v5.i1.103 Shannon, M., & Plummer, V. (2015). Creating pressure awareness in hospitals. Australian Nursing and Midwifery Journal, 23(3):42. Sharma, N., Hunter-Smith, D.J., Rizzitelli, A., & Rozen, W.M. (2015). Surgical view on the management of Madelung’s Disease. Clinical Obesity, 5(5), 288-90. doi: 10.1111/cob.12111 Singh, D., Peavey, C., Bhatnager, M., & Hauptman, J. (2016). Left unilateral electroconvulsive therapy in the presence of intracranial stainless steel wire. Australian and New Zealand Journal of Psychiatry. Advance online publication. doi: 10.1177/0004867416655876

Williams, C.M. (2016). Wait and see, heel raise and eccentric exercise may be equally effective treatments for children with calcaneal apophysitis [commentary]. Journal of Physiotherapy, 62(2), 112. doi: 10.1016/j.jphys.2015.12.003 Williams, C.M., Bowles, K.A., Kiegaldie, D., Maloney, S., Nestel, D., Kaplonyi, J., & Haines, T. (2016). Establishing the effectiveness, cost-effectiveness and student experience of a Simulation-based education Training Program On the prevention of Falls (STOP-Falls) among hospitalised inpatients: a protocol for a randomised controlled trial. BMJ Open, 6(6). doi: 10.1136/bmjopen-2015-010192



Peninsula Health Research Report 2016

Grants Farnbach, E., Evaluating the health and nutrition in 5 SRS facilities. Department of Health and Human Services, $27,000

Layland, J., COlchicine in Patients with Acute Coronary Syndromes, CASS Foundation Research Grant, $66,000

Haines, T., Morris, M., Taylor, N., Holland, A., Carey, L., Skinner, E., Williams, C., Bardoel, A., Martin J., & O’Brien, L., A partnership for evidence-based resource allocation and enhanced research translation in allied health, NHMRC Partnership Project APP 1114210, $616,780.40 [Monash University fund holders]

Layland, J., COlchicine in Patients with Acute Coronary Syndromes, St Vincent’s Hospital Research Endowment Fund Grant, $20,000

Hunter-Smith, D.J., & Rozen, W.M., The implementation of clostridial collagenase histolyticum (CCH) to treat Dupuytren’s disease in the public health system, Actelion Pharmceuticals Australia, $10,000

Spychal, R., Hunter-Smith, D.J., Rozen, W.M., & Chae, M.P., The role of 3D printing in surgery, Department of Surgery, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, $20,000

Celebrating Research 2015 Celebrating Research is an annual event that celebrates and recognises research at Peninsula Health. Events include research prizes for allied health, nursing, junior medical staff, students and interprofessional teams; a poster competition; and the Jeremy Anderson Oration.

Second: Dr George Miller The burden of disease created by cosmetic breast augmentation in Australia. Third: Dr Joy Sha First clinical application of bronchial thermoplasty in Australia.

Professor Sally Green Co-Director of Cochrane Australia Professorial Fellow, Faculty of Medicine, Nursing and Health Sciences, Monash University

Student First: Kai Zheong Lim Epidemiology of patients admitted to a metropolitan intensive care unit following overdose. Second: Dee Zhen Lim and Elizabeth Low Impact of delay in Rapid Response Call on patient outcomes.

Research Prize Winners

Scientific Poster Prize Winners

Allied Health First: Beverley Pearce and Ryan Turnbull Radiographer comment in extremity trauma; research to examine accuracy and implications of use in the changing professional role and the implications of future workflow and patient care in the Emergency Department. Second: Alison Lunt Australian occupational therapists’ experience of working with clients with obesity.

Allied Health Not awarded.

Jeremy Anderson Orator 2015

Interprofessional First: Carol Gore Implementation of a multidisciplinary stroke mood screening and support pathway for inpatient rehabilitation. Second: Georgia Coombes Does the new technology of low frequency ultrasonic debridement pose an infection control risk for clinicians, patients and the clinic environment? Nursing First: Rebecca Thompson Managing aggression (occupational violence): A holistic approach to challenging behaviours in an acute healthcare setting. Second: Tracy Pratt and Anne Tremayne Nursing perceptions of the optimal frequency and type of rapid response training in the subacute hospital setting. Registrar First: Dr Francis Ng Is celecoxib a useful adjunct in the treatment of post-tonsillectomy pain in the adult population? A randomised, double-blind, placebocontrolled study.

Interprofessional First: Reginald Ng, Mr Nigel Broughton and Dr Cylie Williams Clinimetric properties of scoring systems for recovery after ankle fractures: a systematic review. Second: Xenia Jung, Dr Jennifer Grunfeld, Associate Professor Sean Jespersen and Sarah Dickenson Consumer’s attitudes, knowledge and understanding of nominated person in a public mental health service with the Implementation of the Victorian Mental Health Act 2014. Medicine First: Cameron Green, Dr Sachin Gupta, Dr Ashwin Subramaniam, Elizabeth Low, Dee Zhen Lim and Associate Professor Ravi Tiruvoipati Impact of delay in Rapid Response Call on patient outcomes. Second: Dr George Miller, Dr Miguel Cabalag, Ms Marie Rostek, Dr Michael Chae, Dr Tam Quinn, Associate Professor Warren Rozen and Associate Professor David Hunter-Smith Systematic review: Alloplastic adjuncts in breast reconstruction. Nursing: First: Danica Idzes, Associate Professor Virginia Plummer and Dr Helen Hall Methods of induction of labour and birthing outcomes in an Australian maternity service, informing midwifery practice. Second: not awarded.

Office for Research Manager: Lee-Anne Clavarino Office Coordinator: Stacey Hendriks

Peninsula Health’s Research Report 2016 focuses on the achievements and contributions of staff involved in research. For a broader picture of Peninsula Health’s activities over the past year, please see our other annual publications. • Annual Report 2016 – presents our Report of Operations and full Financial Statements. • Quality of Care Report 2016 – highlights Peninsula Health’s progress and achievements in improving clinical care and our consumers’ experience. For further information about Peninsula Health or to download our annual publications, please visit

Acknowledgements Peninsula Health acknowledges the contribution made by all staff involved in research. The Research Report 2016 showcases a small number of these projects but recognises the many ongoing projects and commercially sponsored, collaborative group and investigator-initiated trials in areas such as Allied Health, Anaesthesia, Cardiology, Cancer Services, Community Health, Emergency Medicine, Intensive Care, Mental Health, Nursing and Thoracic Medicine that have the potential to improve the care we offer our patients.

Š 2016 Peninsula Health This work is copyright. You may use material from this publication without altering it for personal or non-commercial use only. You may not store, amend or reproduce material for any other use or by any process without obtaining prior written permission. Requests and enquiries concerning copyright should be addressed to

Research Report 2016  

Peninsula Health Research Report 2016