Journal of
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Orthomolecular Medicine
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VOLUME 34, NUMBER 2 PUBLISHED: JUNE 2019
CASE REPORT
High Dose Vitamin C Therapy for Fever of Unknown Origin: A Case Report
Mohammed Mahmoud Elbarawy,1 Michail Karageorgiadis2 Corresponding Author. Dr Sulaiman Al-Habib Hospital, 11393 Takhassussi Road, Riyadh, Saudi Arabia. e-mail: barawy2000@yahoo.com +966557684755 2American Board of Pediatrics, Dr Sulaiman Al-Habib Hospital. tel.
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Introduction There has been a growing evidence over the last few years of high dose vitamin C as a treatment for several medical conditions including but not limited to cancer, respiratory and systemic infections. (Gonzalez MJ, et al., 2014) prevention of infection requires dietary vitamin C intakes that provide at least proper plasma levels, which maintain cell and tissue levels. In contrast, treatment of established infections requires significantly higher doses of the vitamin to compensate for the increased inflammatory response and metabolic demand.(McGregor GP & Biesalski HK, 2006) Here we report a case of successful use of high-dose vitamin C in the treatment of presumed infection presenting as fever of unknown origin (FUO). Case A 3-year-old girl was brought to the emergency department due to a history of high-grade fever for 8 days with an oral/axillary temperature of --. She sought medical advice several times where she received different oral antibiotics with no improvement. She has no history of any other symptoms and looks well and active between the spikes of fever. Her brother had fever at the same time, he was diagnosed as pharyngitis which subsided on an oral antibiotic and antipyretics. Otherwise, no relevant history or family history. Upon admission, she was vitally stable, clinical examination showed no focus of infection. All imaging studies came back within normal as chest x ray and abdominal ultrasound were unremarkable, while echocardiog-
raphy revealed no vegetations. Blood tests showed white blood cells 12,000 cells/mm3 (neutrophils 8,460 and lymphocytes 2,860), C-reactive protein 8 mg/l, erythrocyte sedimentation rate 42 mm, procalcitonin 0.1 ng/ml. Furthermore, cytomegalovirus serology, monospot test, widal, brucella antibodies, influenza and respiratory syncytial virus swabs, rotavirus and adenovirus in stool were all negative. Moreover, liver function tests, kidney function tests, blood film, rheumatoid factor, antinuclear antibodies, complement 3 and 4 were all within normal. Therefore, apart from the erythrocyte sedimentation rate of 42 mm, all blood tests were normal. Urine analysis initially revealed white blood cells 8-10 per high power field, leucocytes (+) and few bacteria, while nitrite was negative. However, urine and blood cultures revealed no growth. The fever continued for a total duration of 18 days, despite a 5-day-course of intravenous ceftriaxone; therefore, the antibiotic was stopped and high-dose vitamin C was started at a dose of 5 grams oral per day divided into 5 doses; eventually, the fever has subsided gradually over the following 2 days. Furthermore, follow up after one week revealed no more fever or illness; now with follow-up of -- weeks, the patient remains afebrile, with the only response-producing intervention being that of orally administered ascorbic acid. Discussion Close correlation has been found between oxidative stress and viral infectious diseases. The elevated oxidants in-
© 2019 International Society for Orthomolecular Medicine ISSN 0317-0209
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