One Nucleus LSLS Genomics 17 Mar 2015 Programme

Life Science Leadership Seminar ‘Genomics in R&D and Partnering’ 17 March 2015 Mathys & Squire, The Shard, London

Programme 14.30

Registration and Networking over tea and coffee

14.50

Welcome from the Host and Sponsors Craig Titmus, Mathys & Squire Tony Lovegrove, Covance

Session 1: Current Strategies in Genomics and Informatics

15.00

Keynote Address: What are the Current Trends in Genomic Applications in R&D? Anup Madan, Head, Covance (previously LabCorp Genomics)

15.25

Keynote Address: Providing a Collaborative Framework for Health Informatics Research in the UK Georgina Evans, Industry Engagement Manager, The Farr Institute

15.50 Keynote Address: Using Clinical Genomics to Power Translational Research

Will Spooner, CSO, Eagle Genomics 16.10

Keynote Address: The Application of Genetics to Drug Discovery and Development Ciara Vangjeli, Associate Director – Senior Applied Geneticist, Pfizer

16.30

Refreshments

Session 2 16.50 Sequencing with Illumina: from Panels to Medical Genomes

Scott Brouilette, Illumina

17.10 17.30 17.50

Current Partnering Opportunities: Scott Cuthill, Ipsen Georg Buchner, Amgen Juan Ballesteros, Vivia Biotech

18.10

Networking over drinks and canapes

19.30

Event closes

Event sponsor

Event host

Speaker Profiles Joan Ballesteros, Chairman & CSO, Vivia Biotech Title: Native Environment Precision Medicine Joan Ballesteros studied Chemistry in Barcelona, and a PhD in Mount Sinai Hospital, New York, funded by a Fulbright scholarship. Has authored more than 50 publications. In 1999 he founded as CSO Novasite Pharmaceuticals in San Diego, California. He pioneered automated flow cytometry for pharmacological compound profiling. In 2007, he moved back to Spain with the American team and technology to develop a new Precision Medicine test for Hematological Malignancies in Vivia Biotech as Chairman and CSO. The company currently sales its test for AML in Europe to guide patient treatment, and works with 16 companies profiling their candidates in patient samples, developing biomarkers of response.

Scott Brouilette, Senior Marketing Technical Specialist, Illumina Title: Sequencing with Illumina: from Panels to Medical Genomes Scott Brouilette has a PhD in Genetics and spent several years in academic & clinical research. In 2011 Scott joined Partek Incorporated as a Field Applications Scientist (FAS).

Partek develop and market software for advanced statistical and bioinformatic analysis; as an FAS with Partek Scott designed and delivered training and support for existing users, and worked with the R&D team to help guide the development of the product portfolio. This focused heavily on gene expression analysis using both array and NGS technologies. In early 2013 Scott joined Illumina’s Field Marketing team, covering the UK and Ireland.

Georg Buchner, Licensing Director, Amgen Title: Partnering with Innovators to Treat Serious Illness

Georg Buchner, Ph.D. MBA is Amgen’s European Licensing Director. In his Role, Georg has responsibility for Amgen’s business development across therapeutic areas and technologies in Uk, Benelux, Nordic regions, Italy and Israel. Georg previously worked as a consultant for various biotechnology companies in Europe, having worked and closed for a number of years in EU-based biotechnology companies including PolyTherics Ltd., Silence Therapeutics PLC, Novacta Biosystems Ltd., and Haptogen Ltd. Georg has a Ph.D. in molecular genetics from King’s College London, U.K. and an MBA from the Judge Institute, University of Cambridge, U.K.

Scott Cuthill, Senior Director, Corporate Business Development, Ipsen Title: Innovation For Patient Care Through Partnering

Scott Cuthill PhD, Senior Director, Corporate Business Development (CBD) joined Ipsen Biopharm in July 2012. Based in Slough UK, Scott reports to Judith Hills, Senior Vice President of Corporate Business Development at Ipsen. Scott has responsibility for the Business Development activities of the Endocrinology Franchise as well as for Regional Business Development. While at Ipsen, Scott has executed deals for the out-license of Eziclen in Germany to Aptalis, the in-license of Sativex for the treatment of problematic spasticity in multiple sclerosis patients in Latin America and more recently the ex-US, ex-Japan rights toTelotristat etiprate from Lexicon Pharmaceuticals for the treatment of symptomatic NET. Scott joined Ipsen from Chroma Therapeutics, a VC-funded, UK-based biotech company where he was Associate Director of Business Development with responsibility for establishing partnerships for an innovative macrophage-targeting technology where he was instrumental in a transformative deal for the company with GSK. Prior to that Scott held a number of Research positions in the area of Oncology and Viral Diseases at OSI Pharmaceuticals (now part of Astellas) and Roche in the UK. Scott started his career in industry after completing his PhD at the Karolinska Institute in Stockholm and two postdoctoral research positions at the Cancer Research Campaign Laboratories at the Beatson Institute, UK and the Comprehensive Cancer Center UWCC, Madison, WI, US.

Georgina Evans, Industry Engagement Manager, The Farr Institute Title: Providing a Collaborative Framework for Health Informatics Research in the UK

Georgina is tasked with building partnerships and managing commercial collaborations for the Farr Institute, as well as promoting the Insitute expertise and capabilities to industry and other stakeholders. Previously employed by the University of Edinburgh, Georgina spent seven years at the interface between industry and academia, supporting academics in spinning out, commercialising research, developing proposals with industry and public sector. Before moving to Edinburgh, Georgina worked in business development and export marketing roles across the healthcare, life sciences, defence and electronics industries, and managed client and supplier relationships in the UK, Europe, Asia and the United States.

Anup Madan, Senior Technical Director, Genomic Services, Covance (previously LabCorp Clinical Trials)

Title: What are the current trends in Genomic applications in R&D?

Anup Madan, Ph.D. is the Senior Technical Director, Genomic Services at LabCorp Clinical Trials. He is responsible for developing next generation sequencing platforms for providing sequence-based assays as core services by the Seattle site, as well as developing novel assays to support various clinical trials. He has more than 20 years of experience in the field of genomics.

Dr. Madan received his Ph.D. in Biochemical Genetics from Tata Institute of Fundamental Research in Mumbai, India. He did his post-doc in Dr. Leroy Hood’s lab at the University of Washington and played a key role in sequencing of human genome. He still collaborates with Dr. Leroy and other faculty members at the University of Washington on various projects, and was a faculty member at the University of Iowa and Swedish Medical Center where he made significant contributions to the understanding of the etiology of brain tumors. Dr. Madan has published extensively in reputable journals such as Science, Nature, and Cancer Research, among others.

Will Spooner, CSO, Eagle Genomics Title: Harnessing Clinical Genomics to Power Translational Research.

William is a seasoned operational bioinformatician with a track record of delivering tools for high-throughput genomics research. Having worked previously on Ensembl, BioMart, Gramene and WormBase at the European Bioinformatics Institute, the Wellcome Trust Sanger Institute and Cold Spring Harbor, his current focus is on making life easier for users of open source/data in commercial settings. His strategic thinking is driven by the huge opportunities for data analysis in the life sciences provided by the near simultaneous arrival of NGS and cloud computing.

Ciara Vangjeli, Associate Director-Senior Applied Geneticist, Pfizer

Title: The Application of Genetics to Drug Discovery and Development Ciara Vangjeli, PhD, is a Senior Applied Geneticist (Associate Director) at Pfizer Ltd in Cambridge UK. She obtained her PhD in genetic epidemiology and did her postdoctoral work at the Royal College of Surgeons in Ireland in Dublin. Since Jan 2011, she has worked in the Human Genetics group at Pfizer, providing genetics expertise across several therapeutic areas, particularly renal, cardiovascular, and metabolic diseases as well as pain.

Her main areas of interest are the application of genetics for new drug target nomination and in the identification of novel biomarkers for patient stratification in clinical studies.

Delegate List Surname Ahmadi Alavijeh Armisen Garrido Atakhorrami Ballesteros Banister Bartlett Bingham Blair Bland Boehm Branthwaite Braun Brouilette Buchner

First name Khatereh Mo Javier Maryam Juan Nigel Andrew Stephen Eddie Elliot Haydn Paul Emilie Scott Georg

Burgess Chan Charatsi Cribb Cuthill Eccleston Evans Evans-Roberts Fisher Gray Hill Hogg Holt Howe Jones Kanabar Kelly Kleyn Kukula Landh Latter Lovegrove Madan Martins McAlister McConchie Merriman

Ellen Ray Iphigenie Edward Scott Mark Georgina Katy Mike Sam Guy Derek Robert Victoria Tony Pradyp John Dominique Angela Tomas Patricia Tony Anup Maria-Joao Niall Steve Hannah

Company ReViral Ltd Pharmidex Pharmaceutical Services Ltd Horizon Discovery Group plc UCL Vivia Biotech Rare Biotech Ltd Osborne Clarke Ferghana Partners Integrated Medicines Ltd Queen Mary Innovation Ltd Synthonix Ltd TranScrip Partners SANOFI Illumina Cambridge Ltd Amgen Limited Guy's & St Thomas' NHS Foundation Trust Commercial Services Bioline Reagents Ltd Public Health England Fahy Gurteen Laboratories Ipsen OncoLytika Ltd Farr Institute Babraham Institute Enterprise Limited Abcodia Ltd Apposite Capital LLP Preome Ltd Covance Tepnel Pharma Services Mathys & Squire LLP One Nucleus Bio-Analytical Technologies (UK) Limited MRC Technology Sierra MedTech Ltd The Institute of Cancer Research Novo Nordisk London BioScience Innovation Centre Covance Covance Life Sciences Sharing Ideas Olswang Aptus Clinical Limited One Nucleus

Muir Nielsen Parlett Rahman

Andrew Fiona Terry Salman

Sabetnia

Sahar

Saxena Sherman Shivji Smith Sommenvik Spooner Sturgeon Stuttle Thackray Titmus Varney Vengjeli Wallder Warhurst Wood

Alka Howard Nadia Geoff Magdalena Will Tim Alan Theresa Craig Peter Ciara David Nick Adrian

Midven Limited Repositive Consultant Vasgen Ltd University of Leicester- Enterprise & Business Development Office Guy's & St Thomas' NHS Foundation Trust Commercial Services Safeguard Biosystems One Nucleus Illumina Cambridge Ltd Theradex (Europe) Ltd Eagle Genomics Ltd Silence Therapeutics plc The Institute of Cancer Research Covance Mathys & Squire LLP Covance Pfizer Limited Wallder Capital Limited Freelance Consultant Janssen UK