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Lynparza is currently approved in mCRPC for a broad HRR-mutated patient population who have progressed on an NHA recommended by NCCN Clinical Practice Guidelines® In Oncology 1-3

1.de Bono J et al. Olaparib for metastatic castration resistant prostate cancer. N Engl J Med. 2020;382(22):2091-2102.

2. LYNPARZA. Summary of product characteristics.

3. NCCN Clinical Practice Guidelines in Oncology (NCCN guidelines) for Prostate Cancer V.1.2023.National Comprehensive Cancer Network, inc. 2023. All right reserved. Available at NCCN.org. Accessed Sept. 16. 2022

Date of Preparation: NOV 2022

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ksa.ae@astrazeneca.com

For Medical Information Requests, Please contact AZ Medical Information Team through any of the channels below: medinfo-ksa@astrazeneca.com

For medical information:

Medinfoksa@astrazeneca.com

Al - Nakhal Tower - Floor 13th - Ath Thumamah Road

Al Sahafa District. 7198 Unit No. 20 Riyadh 13315 - 3642

Tel: +966(011)22 492 00; Fax: +966(011)22 492 92

For Adverse Event reporting please contact: +966 112249235

Or email: ksa.ae@astrazeneca.com

SA-5977

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