OECD launches Effectopedia, an online Encyclopedia of Adverse Outcome Pathways

Effectopedia is a collaborative research platform, facilitating knowledge exchange between experimental biologists, modelers and chemical risk assessment communities.

An initial set of training material and videos are available on Effectopedia training website http://training.effectopedia.org/ From the website you can learn how to: o Create the visual diagram of an AOP o Build Key Event and Key Event Relationship following the OECD Users’ Handbook for AOP development. o Save an AOP as a local file or publish it on the centralised Effectopedia database o Build simple quantitative models using experimental data o Design and implement interactive executable models using R or Matlab

Effectopedia is a free open source software distributed under GNU General Public License v3.0.

The most recent version is available for download from: Effectopedia website http://effectopedia.org The source code is available on SourceForge : https://sourceforge.net/projects/effectopedia/ Effectopedia is developed by:

with the financial support of

Jan, 2017

Overview

Effectopedia is a tool for building simple quantitative relationships between key events along the AOP using experimental data Experimental scientists can report test data and metadata using OECD harmonised templates and subsequently use an interface to derive simple quantitative relationships between data sets.

Effectopedia is one of the modules of the AOP-KB, recommended for quantitative AOP developers and reviewers.

AOP-Wiki AOP Xplorer

Effectopedia

Adverse Outcome Pathways (AOPs) describe the causal linkages following a chemical stressor and the cascade of biological responses, across different levels of biological organisation, leading to an adverse outcome over time.

The primary goal of Effectopedia is to provide a structured platform for knowledge and quantitative data exchange.

Effectopedia is a tool for visual exploration and development of AOPs, compliant with OECD Users’ Handbook.

The AOP diagram in Effectopedia is a core visual structure used to navigate through the content of existing AOPs. The AOP diagram captures the causal linkages between AOP elements in their biological context. All elements can be described in summary on the diagram for the general public, or in greater detail for the experts.

Role in AOP-Knowledge Base

IEDB

e.AOP.Portal

AOP-XML

Effectopedia is a dissemination and collaboration tool for modelers Effectopedia allows model developers to build a standard description for their models – facilitating interaction with other models. Experiment designers can also use Effectopedia model description to identify the type of data they need to collect in order to build the model. Models are interactive and allow users to modify parameter value and observe the change in behavior.

Third party

• Connects with other modules of the AOP-KB • Provides standard visual representation of AOPs and supporting tests methods • Explicitly captures quantitative information and allow executable models Read more on aopkb.org

Upcoming features (end of 2017) • • • •

Web based version of Effectopedia API services for third party interaction Automatic AOP-Wiki content transfer Import and export of AOP-XML

Training and collaboration

Effectopedia is an open research platform which relies on contributions from scientific community for both content and features suggestions. Please join us in our efforts to build the tool that fits your needs. If your group or research project needs additional information or in person training please contact us at: contact@effectopedia.org