Northwest 50Plus Marion-Polk July 2019 Edition

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Your FREE copy! THE NORTHWEST’S OLDEST AND LARGEST PUBLICATION FOR OLDER ADULTS

rodeo MARION POLK  |  JULY 2019

and other unique Oregon treasures

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+ The Elsinore’s past and present + 5 questions about Alzheimer’s + Creativity at Paxson House VISIT US ONLINE: NORTHWEST50PLUS.COM


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Eye Doctor Helps Portland Legally Blind to See

High Technology For Low Vision Patients Allows Many To Drive Again

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or many patients with macular degeneration and other vision related conditions, the loss of central visual detail also signals the end to one of the last bastion of independence: driving. A Kirkland optometrist, Dr. Ross Cusic, is using miniaturized telescopes that are mounted in glasses to help people who have lost vision from macular degeneration and other eye conditions. “Some of my patients consider me the last stop for people who have vision loss,” said Dr. Cusic, one of only a few doctors in the world who specialize in fitting bioptic telescopes to help those who have lost vision due to macular degeneration, diabetic retinopathy, and other debilitating eye diseases. Imagine a pair of glasses that can improve your vision enough to change your life. If you’re a low vision patient, you’ve probably not only imagined them, but have been searching for them. Bioptic telescopes may be the breakthrough in optical technology that will give you the independence you’ve been looking for. Patients with vision in the 20/200 range can many times be improved to 20/50 or better. Macular degeneration is the leading cause of blindness and vision loss in people over 50. Despite this, most adults are not familiar with the condition. As many as 25% of those over the age of 50 have some degree of macular degeneration. The macula is

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only one small part of the retina; however, it is the most sensitive and gives us sharp central vision. When it degenerates, macular degeneration leaves a blind spot right in the center of vision, making it difficult or impossible to recognize faces, read a book, or pass the driver’s vision test. Nine out of 10 people who have macular degeneration have the dry form. New research suggests vitamins can help. The British medical journal BMC Ophthalmology recently reported that

was prescribed bioptic telescopic glasses to read signs and see traffic lights farther away. Dr. Cusic also prescribed microsope glasses for reading newspapers and menus in restaurants. As the patient puts it, “My regular glasses didn’t help too much – it was like looking through a fog. These new telescopic glasses not only allow me to read signs from a farther distance, but make driving much easier. I’ve also used them to watch television so I don’t have to sit so close. I don’t know why I waited to do this; I should have come sooner.” “Bioptic telescopes can cost over $2,000,” said Dr. Cusic, “especially if we build them with an automatic sunglass.” “The major benefit of the bioptic telescope is seeing faces better and possibly regaining driving privileges as they are legal for passing the driving test for Oregon and Washington.”

A scene as it might be viewed by a person with age-related macular degeneration.

To learn more about bioptic telescopes or to schedule a consultation with Dr. Cusic, give us a call at 1-877-823-2020. You can also visit our website at:

56% of patients treated with a high-dose combination of vitamins experienced improved vision after six months. TOZAL Comprehensive Eye Health Formula is now available by prescription from eye doctors. While age is the most significant risk factor for developing the disease, heredity, smoking, cardiovascular disease, and high blood pressure have also been identified as risk factors. Macular degeneration accounts for 90% of new legal blindness in the U.S. While there is currently no cure, promising research is being done on many fronts. “My job is to figure out everything and anything possible to keep a person functioning, especially driving,” says Dr. Cusic. A patient came to see Dr. Cusic; she wanted to keep her driver’s license and

www.seattlelowvision.com For more information and a FREE telephone consultation, call us today: Offices in Vancouver, WA & Kirkland, WA Ross Cusic, O.D. Low Vision Optometrist, IALVS Member


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rodeo round-up By M A RY OW E N

FROM BUSTING BRONCOS TO BULL RIDERS AND EVEN COWBOY POETRY, THERE’S SOMETHING FOR EVERYONE St. Paul Rodeo

The local rodeo circuit is replete with rodeos, including the St. Paul Rodeo, which celebrates 84 years this month. “Our small community of 300 sees its population balloon to over 50,000 during the five days of the rodeo,” says spokesperson Ruth Nicolaus. “It’s the nation’s greatest Fourth of July rodeo.” The first rodeo was held on July 4, 1936 after locals cleared the city park — a baseball diamond surrounded by scotch broom and littered with tin cans — and built a pole fence around a short quarter mile track. Four bucking chutes and a roping chute were added, and cowboys came from all over Oregon, 50 of them strong, to compete for a rip-roaring purse of $500. “There’s a carnival, the famous Tack Room Saloon — voted one of the top 20 cowboy bars in the west — open for those 21 and older to whet their whistle,” she says. “New this year is our entertaining specialty act, trick riders. Trick riders are Above, bucking horses and their colts gallop through the St. Paul Rodeo arena. (Photo by Hoot Creek) Pages 1 and 6: Scenes from Santiam Canyon Stampede. 4  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019

beautifully dressed cowgirls doing gymnastic-like stunts as the horses gallop around the arena. Fans will get to see Jessica Blair Fowlkes trick ride each performance of the rodeo. “The Wild West Art Show displays artwork for sale, and the Great American Barbecue Cook-off features the wizards of the grill,” she adds. “On the Fourth of July, a parade through the beautiful town of St. Paul takes place, plus fireworks following each night of the rodeo. It’s truly a piece of Americana, all that’s good about America, embodied in the St. Paul Rodeo.” Cowboy Tom Swearingen will debut his poem about the St. Paul Rodeo during the Hall of Fame Barbecue, at 5 p.m. July 2. From Tualatin, Swearingen has attended the rodeo since he was a kid. His cowboy poetry hobby started about 10 years ago with a memorial piece for a good friend who had died. Since then, he’s progressed and flourished in his trade, writing more poetry and performing at cowboy poetry gatherings and invitations to speaking. The rodeo also includes food and merchandise vendors, and a carnival. DATES: 7:30 p.m. July 2-6, with 1:30 p.m. rodeo July 4. TICKETS: $16 to $26 (plus a convenience fee). INFO: StPaulRodeo.com or 800-237-5920. BONUS: The rodeo is a fundraiser for many service and youth organizations around the area and is produced by nearly 100 percent volunteer labor.

Santiam Canyon Stampede

It may be younger than St. Paul, but the Santiam Canyon


Stampede has just as much energy and heart. “All of us at the Santiam Canyon Stampede are very excited for our 23rd anniversary,” says Corky Justis, SCS director of promotions. “As we look to the future, we find it energizes us to keep in mind all the great memories and hard work it took to build the Stampede. We like remembering the fun times we have had together and how those times, have given us the Guy Scott ability to give back to the community.” The Stampede was established in 1997 as a Professional Rodeo Cowboys Association sanctioned rodeo. Following the 1999 season the rodeo was purchased by the community and re-organized as a nonprofit corporation. The reorganization produced the Stayton/ Sublimity Rodeo Association, Inc., as the new owner of the Stampede. The end of the 2010 season saw another change as the Stampede made the move to become a Northwest Pro Rodeo Association-sanctioned rodeo starting in the 2011 rodeo season. Today, Stampede-goers thrill to see bareback riding, barrel racing, bull riding, breakaway roping, saddle bronc riding, and “funny guys with painted faces, spandex shorts and oversized pants classed against a ranked bull” in a fight that will leave your sides aching. “Professional Rodeo announcer Dan Fowlie will be back announcing all the rodeo action happening in the arena, and our professional animal athletes are brought to us by Howell Rodeo Company,” Justis says. “The Stampede is also happy to welcome back clown and barrel man, Clint ‘Wolfy’ Selvester, who has become a crowd favorite.” All rodeo action can be seen and re-seen with the Stampede’s instant replay video score board. “You won’t

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miss a minute of the action,” she says. This spring, the Stampede lost Guy Scott, a rodeo stock contractor and lifetime board member. Scott stayed on after the rodeo transitioned into the nonprofit it is today, Justis says. “Not only did Guy have answers, he always had a story to tell,” she says. “When you were around Guy, you felt

like a kid being told a story. You were always intrigued and on the edge of your seat to hear how it ended. He had a story for everything. It is sad to think he will no longer be able to tell us the living history of rodeo and the champions he knew that helped to form it.” DATES: July 19-20 at Sublimity Harvest Festival Grounds. TICKETS: Adults are $13 in advance; $17 at the gate. Youth ages 5-12 are $9 in advance, $13 at the gate. Tickets sold at Double H Western Wear in Salem; Riverview Bank in Aumsville; Wilco Farm Stores in Stayton, Silverton, Oregon City and Lebanon; and on the Stampede website. WEBSITE: scsrodeo.com. BONUS: Kids Corral, free on Friday night, an official Stampede after-party, Mutton Bustin’ for the kids, music, royalty, and the Sublimity Firefighters Cowboy Breakfast. Proceeds from the Stampede are dispersed to various youth groups in the Sublimity-Stayton area. ☸

Other area rodeos:

▶▶Molalla Buckaroo Rodeo: June 29-July 2, Molalla. Info: 503-829-8388 or molallabuckeroo.com. ▶▶Philomath Frolic & Rodeo: “Boots, Chaps, and Cowboy Hats!” on July 11-13, Philomath. Info: 541-929-2611 or philomathfrolic.org. ▶▶Marion County Fair Hell on Hooves Rough Stock Rodeo: July 13 at the Marion County Fairgrounds, Salem. Info: 541-895-5335 or co.marion.or.us/ CS/Fair. ▶▶Benton County Fair & Rodeo: July 31-Aug. 3, at the Benton County Fairgrounds in Corvallis. Info: 541-7666521 or FestivalNet.com. ▶▶Polk County Fair Hell on Hooves Rough Stock Rodeo: Aug. 8 at the Polk County Fairgrounds, Rickreall. Info: 503-623-3048 or co.polk.or.us. ▶▶Lincoln County NPRA Rodeo: July 5-6, Lincoln County Commons (Fairgrounds), Newport. Info: 541-2654961 or ticketleap.com.

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NORTHWEST LIVING  |  UNIQUELY OREGON

Sweet Home hikes O

ESCAPE TO THE CASCADE MOUNTAINS THIS SUMMER NE OF OREGON’S MOST BEAUTIFUL TREAsures lies in the Sweet Home Ranger District of the Willamette National Forest.

This summer, professional rangers will be leading guided tours, sharing information about plants, animals, geology and the cultural history of the area. Sweet Home Nature and Heritage Tours lead guests to outof-the-way spots to explore, learn and have a wonderful time Hikers on Browder Ridge Trail last year enjoyed the spectacular scenery of Willamette National Forest. Guided hikes are available this year. (Photo courtesy of Willamette National Forest)

while coming to appreciate why the Sweet Home area is such a special place. This year, there will be a number of hikes offered on topics that include general outdoor preparedness, wildflowers, and the long history of the Kalapuya tribe in the Willamette Valley. Hikes range from easy to difficult. Additionally, there are opportunities to make art in nature, paddle board, horseback ride, conduct citizen science projects and mountain bike. Registration for guided tours is handled through the National Recreation Reservation System. Visit recreation.gov or call 877-444-6777 and press “one” for tours. There is a $3 service fee per tour in addition to tour fees. These events are offered under the Recreation Fee Program authorized by The Federal Lands Recreation Enhancement Act. These fees fund protection and enhancement of local historic sites for public use and enjoyment and the continuation of conservation education programs. ☸

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YOUR HEALTH  |  CHRONIC CONDITIONS

5 Questions AN INTERVIEW WITH OHSU RESEARCHERS ABOUT ALZHEIMER’S

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LZHEIMER’S IS A TRIPLE threat unlike any other disease — with soaring prevalence, lack of effective treatment and enormous costs. The Alzheimer’s Association is the world’s largest nonprofit funder of Alzheimer’s research and has invested over $455 million in nearly 3,000 scientific investigations since 1982. The Alzheimer’s Association-Oregon and Southwest Washington Chapter collaborates with Oregon Health Sciences University to work toward methods of treatment, prevention and, ultimately, a cure. Responses to the below research questions are provided by the following members of the OHSU Rex and Ruth H. Layton Aging and Alzheimer’s Disease Center, one of 29 Alzheimer’s Disease Centers in the United States recognized by the National Institutes of Health and the only one of its kind in Oregon: ▶▶Allison Lindauer, Ph.D., N.P., assistant professor of neurology, OHSU School of Medicine. ▶▶Aimee Pierce, M.D., associate professor of neurology, OHSU School of Medicine. ▶▶Lisa Silbert, M.D., M.C.R., associate professor of neurology, OHSU School of Medicine

1.

WHAT ARE THE CAUSES OF ALZHEIMER’S DISEASE? The exact causes of Alzheimer’s disease are not known however we do know that Alzheimer’s is associated with a build-up of abnormal proteins in the brain, called plaques and tangles. There is also reduced metabolism and blood flow in the brain, reduced synapses (connections between brain cells or “neurons”), and death of neurons. Possible causes of Alzheimer’s under investigation include age-related changes in cellular “waste processing,” inflammation, and cerebrovascular dysfunction. IS THERE A CONNECTION BETWEEN ALZHEIMER’S DISEASE AND HEART HEALTH? It is well known that high blood pressure and other heart disease risk factors are associated with increased risk of cognitive decline and dementia in older individuals. While this has been thought to be mainly due to the associated increased risk of stroke and cerebrovascular disease, there is recent evidence linking heart disease risk factors more specifically to Alzheimer’s disease pathology. For example, there have been several studies showing that individuals with hardening of the arteries (or atherosclerosis, a known risk factor for heart disease) have more amyloid

2.


plaques in their brain, one of the two pathological hallmarks of Alzheimer’s disease. The growing evidence linking “heart health” to “brain health” suggests that measures taken to prevent heart disease and stroke, such as maintaining adequate blood pressure control, a healthy diet and frequent exercise, could potentially reduce your risk of dementia, including that from Alzheimer’s disease, as you grow older. CAN YOU SHARE ANY TIPS FOR HOW TO REDUCE YOUR RISK OF COGNITIVE DECLINE? Diet, exercise and social engagement are important at any age, and research shows that these things can reduce the risk of developing dementia in older adults. Breaking a sweat seems to reduce the risk, and we know that the risk is also reduced for people on a Mediterranean diet rich in plantbased foods, whole grains, legumes and nuts. We also know that when people are socially engaged, with friends or family, it helps to protect their brains. WHAT IS THE LATEST IN ALZHEIMER’S DISEASE-RELATED RESEARCH AT OHSU? We are conducting several novel clinical trials at OHSU, testing new treatments for Alzheimer’s disease. Some of these treatments include antibodies that block or clear amyloid and tau proteins in the brain, the proteins that form plaques and tangles. We are also testing treatments that may prevent Alzheimer’s in healthy older adults who are at

3.

4.

higher risk of developing the disease due to their genes. In addition, we’re working through our telehealth program to help caregivers identify triggers for distressing behaviors in seniors experiencing cognitive decline. OHSU is also testing a clinical intervention called I-CONECT to test whether guided conversations by video can stave off dementia in socially-isolated seniors. WHY IS IT IMPORTANT FOR INDIVIDUALS TO PARTICIPATE IN CLINICAL TRIALS? There is currently no treatment that can slow or reverse the progression of Alzheimer’s disease. Physicians, scientists, patients and families are all desperate to find new treatments, and the only way to do so is to conduct clinical trials to learn more about Alzheimer’s and test treatments in patients. Clinical trials cannot be performed without willing and devoted patients. It is highly likely that the first patient to be cured of Alzheimer’s will be a participant in a clinical trial. Some of the benefits of being in a clinical trial include access to novel treatments and technology, treatment by experts in the field, close monitoring of your overall health and brain, and the knowledge you are helping future generations have a chance to live in a world without Alzheimer’s. ☸

5.

To learn more about the Alzheimer’s Association visit alz.org. To learn more about OHSU, visit ohsu.edu.

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MARION POLK  |  JULY 2019  NORTHWEST 50 PLUS  9


NORTHWEST LIVING  |  UNIQUELY OREGON

The Elsinore By M I C H E L L E T E

I

GETTING UP CLOSE AND PERSONAL WITH THIS SALEM LANDMARK

N 1926, THE ELSINORE THEatre opened in downtown Salem as a silent film house and vaudeville venue, and for yearly 100 years has provided a variety of artistic opportunities to the Salem community. Did you visit The Elsinore to see a blockbuster movie, a silent film, a touring dance company or maybe a comedian? Now a nonprofit venue benefitting from a $3.4 million upgrade that restored the Tudor Gothic-style building to its original glory, promoters are working hard to provide first-run entertainment that attracts both local Above, the Elsinore Theatre stage is one feature that sets this venue apart. (Salem Photo League)

and wider audiences. Here are a few facts, provided by executive director Tom Fohn, marketing maven Carlee Wright, and development director Sally Litchfield Puhek, about where The Elsinore has been and where it’s going. You’ll want to check it out. WHERE DID THE ELSINORE GET ITS START? It was the vision of George B. Guthrie, a prominent attorney from Portland who built it in the era of grand atmospheric movie palaces, where the real world is left outside as the patron enters a completely different world. It drew its name from Shakespeare’s “Hamlet.” SPECIAL FEATURES? Above the theatre entrance is a stained-glass scene of Hamlet, with accompanying side windows of Portia and Lady Macbeth. The upper balcony features spectacular windows of Elsinore Castle at sunset. FIRST MOVE PLAYED AT THE

10  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019

ELSINORE? On May 28, 1926, it opened with two sold-out showings of “The Volga Boatman,” directed by Cecil B. DeMille. EARLY FAMOUS VISITORS: Edgar Bergen (and Charlie McCarthy), Otis Skinner, The John Phillip Sousa Marine Band, and Clark Gable. LIVE MUSIC: A mighty Wurlitzer organ accompanied the first silent films. The organ was a medium-sized instrument with 900 pipes installed in four rooms above the proscenium. It was replaced in 1986, and is now played by Rick Parks during tours and silent film showings. WHAT IS TODAY’S VISION? Promoters say its purpose is to offer arts and cultural performances that improve individual development, enhance the quality of life and contribute to the economy of Oregon’s capital city. The fundamental service of the vintage Elsinore is to present live performances on stage.


THE ICONIC STAGE: This is the heart of the Elsinore, and our mission is to grace it with the finest acts and cultural events possible for the enrichment of this community. WHAT MAKES IT FUN TO WORK AT THE ELSINORE? CARLEE: You’re teasing, right? What’s not to love about working at the Elsinore? We do fun. We see people relaxed, being entertained and connecting with others in the community. DO YOU STILL SHOW FILMS? CARLEE: We’ve shown movies here for decades. It’s one way people identify with us. This season we’ve added a 2 p.m. show for people who don’t drive after dark. We have a wonderful partnership with Roth’s Fresh Markets which provides buy one, get one free coupons. Where else can two people enjoy a classic film for $6? WHAT’S BEEN YOUR MOST POPULAR SHOWS RECENTLY? CARLEE: Pink Martini, Kris Kristofferson and the musical “Disenchanted.” WHAT ABOUT YOUR UPCOMING SEASON? TOM: I’m excited about it because we’re really getting shows Salem is not supposed to get: Jeff Foxworthy and “We Will Rock You: The Queen Musical” are perfect examples. These are big shows and when the only place people can see them is in Salem, it’s good for more than just the theater. WHAT ABOUT ORIGINAL PRODUCTIONS? TOM: We’re producing musicals now and recently were awarded

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“A Christmas Story The Musical,” produced by the Elsinore Theatre, is part of its Broadway Series. It will return to the stage this December.

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SPEAKING OF HELPING UP-AND-COMING TALENT: SALLY: The Elsinore has a new project with North Salem and McKay high schools called SPARK – Salem Performing Arts Reward Konnection. We use private donations and grant funds directed to SPARK to provide free tickets for school staff to award to underserved students making strides toward graduation. CAN I VOLUNTEER? SALLY: Yes, the events at The Elsinore could not happen without the dedication of our amazing team of volunteers who work as ushers, ticket takers, concessionaires and box office attendants. In 2017-18, 155 volunteers donated 8,830 hours. If you have an interest in volunteering, contact the Administrative Office for an application. I WANT TO ATTEND A SHOW: Always start with the website, ElsinoreTheatre.com, where you can view a schedule of events and purchase tickets. If you go directly to a reseller’s site, ticket prices will be much higher. Tickets can be purchased from the box office or administrative office, from 9 a.m. to 5 p.m. Monday through Friday. Or call 503-375-3574 to order with a credit card. LOCATION: The Elsinore Theatre is located at 170 High St. SE, in downtown Salem. There is free parking on all streets in the area. ☸

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12  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019


NORTHWEST LIVING  |  YARD & GARDEN

the fruits of summer By G RAC E P E T E R S O N

RIPE BERRIES BURSTING WITH FLAVOR ARE ONE OF THE PERKS OF AN OREGON SUMMER

T

HINKING BACK ON PAST Julys, one of the first things that comes to my mind is the heat. It’s not uncommon to have no rain and a three-day — or more — stretch of 90-degree weather this month. (But I’m praying that we won’t.) This means that unless you are a “super gardener” and love the baking sun, the chores will need to be done in the early morning or evening hours. I am a weather wimp and wilt just like the plants when forced to endure anything over 85 degrees. From about 11 a.m. to 4 p.m., I’m either indoors or in the shade, hopefully sipping iced tea. Despite the possibility of a heat wave, July is a fabulous month in the garden. Flowers are blooming everywhere providing nectar for hungry critters and the first veggies are ready to pick providing food for hungry people. What’s not to love about that? Then there are the berries. Just when we’re getting tired of fresh strawberries (not really), nature serves up another round of fresh goodies. Raspberries and blueberries, marionberries and more. Living in Oregon means you can enjoy local summer fruits, such as these “Fall Gold” raspberries (far right). (Photo by Grace Peterson)

Eaten fresh off the bush, the sun-warmed sweetness is one of the most enjoyable pleasures of high summer. I grow two types of ever-bearing raspberries — ever-bearing, meaning they produce two crops each season. ‘Heritage’ is a fat, juicy red berry and ‘Fall Gold’ is a yellow/orange, slightly smaller but sweeter variety. Both varieties grow in their own raised bed. While the plants don’t require special fertilizer to grow and produce bountiful crops, an annual top dressing of three or four inches of shredded leaf compost is a good way to keep the soil moist between waterings. Once the first crop of berries has finished, usually in mid-July, I cut those canes down which makes more room for the emerging canes that will produce another crop in September. My blueberries also grow in a raised bed. A few years ago, after neglecting them longer than I care to admit, I researched how I could get my plants to look similar to those healthy, berry-loaded plants I see at blueberry farms. I discovered that like raspberries, blueberry plants prefer consistently moist, freely draining soil to produce the best crop. So, top-dressing with shredded leaf compost to insulate the soil’s moisture has become a routine chore. I also take the advice from “Growing Blueberries in Your Home

Garden,” an informative handout published by Oregon State University Extension Service. This handout spells out blueberry growing guidelines, from site preparation to selecting the right variety, pruning techniques and even growing plants in containers. Since my plants were already sited and growing, I didn’t need to focus on that aspect. However, the pruning and fertilizing guidelines have been very helpful. I’m seeing the results. The plants are loaded with berries this year. So much so, that I decided it was time to invest in a roll of inexpensive horticultural netting to keep the hungry birds at bay. Even if you only have a small patio, you can grow berries. A little effort pays off big in July, when you’re eating your own homegrown, nutritious and delicious fresh fruit. ☸

Of note

https://catalog.extension.oregonstate.edu/ ec1304/html

MARION POLK  |  JULY 2019  NORTHWEST 50 PLUS  13


open

NORTHWEST LIVING  |  UNIQUELY OREGON

an

house

By M A RY OW E N

PAXSON HOUSE IS A HOTBED OF CREATIVITY — JOIN IN

W

HAT MAKES YOU FEEL LOVE, MAKES your heart sing, or lights up your life?

If it’s creativity, Paxson House, Center for Creative Endeavors, may be just what you need. What makes owner and artist, inspirational author and creative encourager Connie McDonald come to life are “dancing with my husband, engaging in anything creative and colorful, watching children play, connecting with kindred-spirit friends, and ‘ah ha’ moments when I see the love of God surrounding me in nature, in repeated themes, everywhere I turn.” To help others with their search for creative joy, McDonald and her husband, Tim, a professional photographer, opened Paxson House and held an open house in January. The couple named their south Salem home Paxson House for two reasons. “First, our classic home built in 1939 was designed by Glen Paxson, the premiere bridge architect for over 27 Oregon bridges,” McDonald says. “He was the first owner of our home. “The second reason we call it Paxson House is because of the Latin translation of ‘pax’ which means ‘peace,’” she adds. “Hence ‘son of peace,’ which describes the feeling one has when they Above, Paxson House was designed by a bridge architect. Right, Connie McDonald with her new book. 14  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019

are in our home. I like to think that the warm and welcoming atmosphere is felt by all who enter.” When the couple bought their place almost 15 years ago, they felt that they were to be good stewards of its use. “Tim has steadily improved and remodeled many of the rooms, leaving the charm of the home intact,” McDonald says. “Being an entrepreneur and former restaurant/catering owner in the Willamette Valley for a good 20 years, hospitality seems to be in my blood. However, my creative talents have taken an upward turn focusing on teaching and facilitating creative classes in our group art studio in the converted basement.” Turning her talents for creating edible art in a culinary world to creating expressive art wasn’t much of a stretch for McDonald. “I’m passionate about all forms of creativity,” she says, “whether it be collage, abstract painting or wearable art.” The couple recently returned from a trip to Italy, where they learned how to use acrylics to creatively design silk scarves. “We came back on fire to teach others the techniques in paper and fabric,” McDonald says. “My husband helps me with the creative end.” Together, the couple creates custom marbling silk scarf trays for “folks to come and create their own silk


scarves by “painting on water.” They both convey this style of painting “is remarkably easy.” Encouraging creativity is McDonald’s passion. She loves to help folks of all ages to create, have fun, and experience other Paxson House offerings, including acrylic pour parties. McDonald says one of the most successful classes was “Girls Night Out” in which 10 ladies were taught acrylic pour painting on tiles and canvasses. “Another fun experience was the three generations — mother, grandmother and mom’s young adult daughters — having an ‘artful play’ quality tie with abstract acrylic pour and alcohol ink,” McDonald says. “Our most recent fabulous class was four to five women who created two one-of-a-kind marbleized silk scarves while having a great time. Also, our first mobile Sip and Play Acrylic Pour class was held in the fall at the 13th Street Nursery in southeast Salem.” McDonald loves to encourage people of all ages to have fun while experiencing one of her art classes. In addition to the acrylic pour parties, she specializes in Vision Board parties and coaches one-on-one with folks who are in life or career transition, and, she says, “want help envisioning their vocation or the like.” A group of six taking the Fluid Art Fun class pays $35 per person, instruction and materials included, for more than two hours of creating 8-inch-by10-inch abstract art canvasses and one tile. The class requires a minimum of six people. “Participants in the marbleized silk scarves class create two silk scarves to take home, one 15-inches-by-60-inches and the other 8-inches-by-54 inches,” McDonald says. The class includes two hours of instruction, all materials, and is $40 per person with a minimum of five people. Vision Board parties are three hours, include all materials and “encouraging guidance” and are for a minimum of six people for $35 each. “We are also open to having guest

Paxson House offers classes, like acrylic pour, that allow individuals to explore their creative side. (Courtesy photos)

teachers possibly rent the space to teach, or collaborate,” McDonald says. “We also can bring the joy of creativity to your office, your home, or at your chosen venue.” Paxson House is officially on Airbnb, but McDonald says opening it up for rental is “on pause.” “We most likely will open up one to two rooms in May, with a shared bathroom,” she says of the option for artists or others from out of town to stay over. McDonald’s new book, “Embracing God’s Rainbow” reflects how God took her from “black and white to Technicolor living.” The book tells her personal story “from breakdown to breakthrough, fear to freedom, sorry to joy, and the transformational tools

that God used of creativity,” she says. “This is also a workbook/playbook for healing, restoration of joy and wellness, and healing our image of God.” Her book can be found at Amazon. com. McDonald graduated from the SAGE Legacy fellowship program, where, with team partner Cynthia Lester, she completed a project, “Restoring Joy and Wellness through the Arts.” ☸

Of note

Learn more about the fellowship program at wearesage.org. For more information on Paxson House, text 503-851-9587, visit them on Facebook, email conniestimetoshine@gmail.com, or paxsonhouse.com.

Independence Day Is July 4th A Day of Remembrance Avenue Of Flags

City View lines the cemetery roads with the flags of deceased veterans that their families have donated.

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MARION POLK  |  JULY 2019  NORTHWEST 50 PLUS  15


NORTHWEST LIVING  |  YOUR FINANCES

7 estate planning tips W

FOR OLDER ADULTS

E ALL FACE UNIQUE CHALLENGES AS we age, but with proper planning, you and your loved ones can be well-prepared to successfully navigate this stage of life.

“Even if you’re not geographically close to your senior parents or, if you are the senior, to your children, there are several important things we can do here and now to protect seniors,” says John O. McManus, a trusts and estates attorney based in New York. “Making the time to plan ahead can save you and your loved ones from headaches and regrets, in addition to preserving family wealth.” Here are seven tips for smart planning. Anticipate, before it’s too late. As we age, there is a significantly greater risk of incapacity. The failure to prepare a health care directive and living will, authorization for release of protected health information, and durable general power of attorney means that family members will be compelled

1.

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Contact the Waitlist Department at 541-743-7164 16  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019

to seek court intervention if you are ill, become unconscious, have diminished capacity, or experience some other emergency. This results in unnecessary delay and expense and will be completely inadequate if your loved ones need to make a health care decision or act on your behalf. Spend a little time planning to save a lot of time doing. The need for the court to oversee the administration of an estate can be time-consuming, costly and frustrating. Proper planning will allow for the probate process to be completed with greater expediency. This includes the preparation of revocable living trusts, the assets of which will not be subject to court review (even if the property is owned in another state), and updates to the titling and beneficiary designation of your assets to ensure a far more efficient estate administration. Take advantage of the opportunity of a lifetime (gift tax exemption). Dramatically reduce future potential federal estate tax by utilizing the temporary increase to the lifetime gift exemption. The Tax Reform and Jobs Act enacted at the beginning of 2018 significantly raised the federal estate tax exemption, but the current law

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will expire no later than Dec. 31, 2025. Furthermore, Congress can act sooner to reduce the increased exemption. Don’t skip over generation-skipping tax. Understand the tax implications of the transfer of wealth across multiple generations to preserve your legacy for your descendants. Generation-skipping tax (GST) and the use of the GST exemption are among the most sophisticated planning concepts, but it is essential to consider this issue as part of the larger estate plan. Bequests in trust to grandchildren, the design of a dynasty trust, and the proper reporting of gifts are all connected to the deployment of the GST exemption and avoiding the imposition of additional tax when an inheritance is received by more remote descendants. Decrease your chances of an increase in federal income taxes. Evaluate strategies to avoid a potential increase in federal income taxes due to limitations on state and local tax deductions. Different types of out-of-state trusts provide planning opportunities before the liquidation of an appreciated investment or business. Furthermore, life insurance, Roth IRA conversions, and contributions to charitable vehicles (including private foundations and charitable remainder trusts) afford opportunities to mitigate state income tax exposure.

4.

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Step up your planning with a step-up in basis. Review the power of a step-up in basis upon death, reducing capital gains tax and delivering income tax savings your loved ones can enjoy. Families must consider proper planning in advance of death. Asset transfers to an ailing spouse, community property trusts, asset swaps from existing irrevocable trusts, and asset upstream gifting to parents are all options to put the surviving spouse, children, and other heirs in the best position to sell an appreciated asset tax-free. Plan for long-term care in short order. The cost of

7.

long-term health care could drastically deplete an estate, but strategies may be available to mitigate the attrition of assets. In addition to traditional policies, life insurance policies can be structured with an accelerated death benefit to cover the cost of nursing home care and/or provide wealth replacement if other resources are diminished. Medicaid trusts and supplemental needs trusts also afford the possibility that assets may be preserved for the use of a surviving spouse or provide a meaningful legacy for children without sacrificing the ability to qualify for governmental benefits. ☸

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Reflections on the River Join us for a short program of celebration, reflection and a veteran honoring ceremony.

C E L E B R AT E · R EM EM B E R · H O N O R Thursday, Sept. 5, 7:30 pm | Salem Riverfront Park

Willamette Valley

Order your personalized luminaria to honor your loved ones at wvh.org

45302-Reflections on the River Ad.indd 1

6/11/19 10:29 AM MARION POLK  |  JULY 2019  NORTHWEST 50 PLUS  17


July 2019 HAPPY INDEPENDENCE DAY ✮ ENJOY THESE SUMMER ACTIVITIES!

JUNE 28 — REVITALIZE

GENEALOGICAL SOCIETY GROUP WORKSHOP, “Approaches to Solving a Brick Wall,” noon to 1 p.m., Anderson Room A, Salem Public Library, 585 Liberty St. SE. 503-363-0880.

DOWNTOWN STAYTON CONCERT WITH ADRENALINE RUSH, 5 to 10 p.m., Third Avenue and Florence Street. More concerts July 19 and Aug. 23. (THROUGH JUNE 30) WORLD BEAT FESTIVAL, Riverfront Park, Salem. Worldbeatfestival.org.

1 — (THROUGH JULY 4) FIREWORKS BOOTH, 9 a.m. to 9 p.m., Roth’s gravel parking lot, Silverton. Benefits Silverton Senior Center and Lions Club. LINE DANCING LESSONS, 12:30 p.m. Mondays, through July 28, Silverton Senior Center, 115 Westfield St. 503873-3093. HULA LESSONS AND UKULELE SONG CIRCLE, 4 p.m. Mondays, through July 28, Silverton Senior Center, 115 Westfield St. 503-873-3093. FRESH PRODUCE COOKING, 4 p.m. Mondays, through July 28, Silverton Senior Center, 115 Westfield St. $5. 503-873-3093.

27 SATURDAY

WATER LANTERN FESTIVAL 6 to 10 p.m., Cascade Gateway, 2100 Turner Road SE, Salem. Waterlanternfestival.com/ salem.php

9 — INTEGRATIVE WELLNESS, 6 p.m., Silverton Senior Center, 115 Westfield St. $10/$20. 503-836-7455.

10 — STAYTON CAREGIVER

RODEO, 7:30 p.m., plus a 1:30 p.m. July 4 matinee. $16-$26. StPaulRodeo. com.

CONNECTION, support group for unpaid caregivers of those with dementia, 1 to 2:30 p.m., meeting room, Stayton Public Library, 515 N. 1st Ave. Topic: Steps to Preventing Caregiver Burnout. 503-304-3432.

3 — BINGO, 1 p.m. Wednesdays, 12:30 p.m. through July 31, Silverton Senior Center, 115 Westfield St. $1.50/card. 503-873-3093.

(THROUGH JULY 14) THEATRE 33: “BETHANY SEES THE STARS, 7 p.m., Pelton Playhouse, Willamette University. Theatre33.org.

BINGO, 12:30 to 3:30 p.m., Keizer/ Salem Area Seniors, 930 Plymouth Dr. NE, Keizer. $5.50.

11 — (THROUGH AUG. 31) “SEX PLEASE WE’RE 60,” 7:30 p.m. Thursdays to Saturdays, Theatre West, 3536 SE Hwy. 101, Lincoln City. Theatrewest.com.

2 — (THROUGH JULY 6) ST. PAUL

JULY 3RD CELEBRATION AT THE OREGON GARDEN, 5 to 11:30 p.m., 870 W. Main St., Silverton. Free. 503874-2519.

4 — SANTIAM CANYON SCAVENGER HUNT, 10 a.m. to 6 p.m., Kimmel Park, Mill City. Nschamber.org. (THROUGH JULY 7) CHERRYFEST NW, 11 a.m. to 10 p.m., Riverfront Park, 200 Water St. NE, Salem. Cherryfestnw.com. 18  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019

12 — THE SECRET HISTORY OF UNDERGROUND SALEM, 6 to 8 p.m., Deepwood Museum and Gardens, 1116 Mission St. SE, Salem. $20. 503363-1825.

13 — SILVERTON SENIOR CENTER TRIP: SISTERS QUILT SHOW, 503873-3093. WILLAMETTE VALLEY

WORKSHOP: BERRY TASTING VARIETY SELECTION AND BASIC BERRY CARE, 9 a.m. to noon, Marion Garden, Salem. Marioncomga.org. SATURDAY NIGHT DANCE AND POTLUCK, featuring Lee Nicholas and Diane, 7 to 10 p.m., Keizer/Salem Area Seniors, 930 Plymouth Dr. NE, Keizer. $5. ST. BENEDICT FESTIVAL, noon to 4 p.m., Mount Angel Abbey. Mountangelabbey.org/sbf. FARM TO TABLE DINNER AND AUCTION, 6 to 9 p.m., Willamette Heritage Center, 1313 Mill St. SE, Salem. Marionpolkfoodshare.org. 234 ARMY BAND CENTENNIAL TOUR, 7 p.m., Elsinore Theatre, 170 High St. SE, Salem. 503-375-3574.

14 — LINE DANCE PARTY, 4 to 7 p.m., Silverton Senior Center, 115 Westfield St. $5. DWIGHT YOAKUM, 8 p.m., Elsinore Theatre, 170 High St. SE, Salem. Etix. com. MARION COUNTY FAIR TRASHION SHOW, 11 a.m. Fashions must be at least 75% recyclable materials. Co.marion.or.us.

16 — NORTH SALEM/KEIZER CAREGIVER CONNECTION, a support group for unpaid caregivers of those with dementia, 1 to 3 p.m., second-floor conference room, NorthWest Senior and Disability Services, 3410 Cherry Ave. NE, Salem. Topic: Fall prevention. 503-304-3432. GARDEN BRUNCH TEA, 10 a.m., Deepwood Museum and Gardens, 1116 Mission St. SE, Salem. $35. 503-3631825, ext. 303.

19 — (THROUGH JULY 20) SALEM


GREENE ESTATES ANNUAL PARKWIDE SALE, 9 a.m. to 3 p.m., 4730 Auburn Road NE, Salem. Some sales benefit American Council of the Blind. (THROUGH JULY 20) TERRACE LAKE PARK ANNUAL MULTI-HOUSE GARAGE SALE, 2120 Robins Lane SE, Salem.

20 — IRIS DIG WITH JOYCE HEINKE, OSU Master Gardener, 9 a.m. to noon, 3374 Jefferson Marion Road, Jefferson. Free. Marioncomga.org. SATURDAY NIGHT DANCE AND POTLUCK, featuring Crossfire, 7 to 10 p.m., Keizer/Salem Area Seniors, 930 Plymouth Dr. NE, Keizer. $5. PASEFIKA HAWAIIAN LUAU, 5 p.m., Cascade Gateway Park, 2100 Turner Road SE, Salem. Benefits Moving Forward. $20. Movingforwardtosuccess.org.

26 — (THROUGH JULY 28) AUMSVILLE COMMUNITY THEATRE: “DEATH TAKES A HOLIDAY, 7 p.m., the Little Red Schoolhouse, Stayton. Staytonevents.com.

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27 — FRUIT TREE BUD GRAFTING WITH OSU MASTER GARDENERS, 9 a.m. to noon, Marion Garden, Salem. Marioncomga.org. SATURDAY NIGHT DANCE AND POTLUCK, featuring Jefferson Parks, 7 to 10 p.m., Keizer/Salem Area Seniors, 930 Plymouth Dr. NE, Keizer. $5. ALL STAYTON BEAN FESTIVAL YARD SALE, 10 a.m. to 3 p.m., Brown House Event Center, 425 N. First Ave., Stayton. Brown House tours offered, suggested $5 donation.

28 — SHOW-N-TELL WITH WRITER/ARTIST BOB FOSTER, 7 p.m., Silverton Senior Center, 115 Westfield St. ☸ Calendar listings must be submitted no later than the 6th of the month for events happening in the following month, to mte@northwest50plus.com.

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MARION POLK  |  JULY 2019  NORTHWEST 50 PLUS  19


Aumsville Community Theatre has a spot for you

Don’t Wait Until Your Basement is Flooded...

Aumsville Community Theatre, established during the city’s centennial celebration in 2011, continues to thrive and expand. In addition to traditional performances, members have taken on old-time radio for a series of shows this summer. Act-on-Radio is a traveling troupe that performs murder mysteries, live old-time radio dramas and an evening of songs. Murder mysteries even get the audience to participate. “We have successfully staged ‘Act-on-Radio’ evenings for a variety of groups and organizations throughout the Willamette Valley,” says Ed Stiner, board member. In May, the troupe presented “Inner Sanctum.” In June, the show was titled “Advs of Philip Marlowe,” with episodes titled “The Red Wind” and “Trouble is My Business.” “Death Takes a Holiday” is the title for July’s performances, at 7 p.m. July 26-28. In August, the closing performance will be “The Green Hornet,” Aug. 16-18. All performances take place in the Little Red Schoolhouse in Stayton. More volunteers are needed. Become a member, attend a fundraising event, help distribute posters in your area, or help build sets. Volunteers also are needed to sew costumes; be a crew members; donate props, costumes, concessions and funds; usher; audition for a part; or be a sponsor. Call 503-3856653 or follow Aumsville Community Theatre on Facebook. ☸

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1 Guaranteed not to clog for as long as you own your home, or we will clean your gutters for free. 2 Does not include cost of material. Expires 7/31/19 3All participants who attend an estimated 60-90-minute minute in-home product consultation will receive a $100 gift certificate. Visit https://www.restaurant.com/about/terms for complete terms and conditions and https://www.restaurant.com for participating restaurants. Retail value is $100 $100.. Offer sponsored by LeafGuard Holdings Inc. Limit one per household. Company procures, sells, and installs seamless gutter protection. This offer is valid for homeowners over 18 years of age. If married or involved with a life partner, both cohabitating persons must attend and complete presentation together. Participants must have a photo ID, be able to understand English, and be legally able to enter into a contract. The following persons are not eligible for this offer: employees of Company or affiliated companies or entities, their immediate family members, previous participants in a Company in-home consultation within the past 12 months and all current and former Company customers. Gift may not be extended, transferred, or substituted except that Company may substitute a gift of equal or greater value if it deems it necessary. Gift card will be mailed to the participant via first class United States Mail within 10 days of receipt of the promotion form. Not valid in conjunction with any other promotion or discount of any kind. Offer is subject to change without notice prior to reservation. Expires 7/31/19. ⁴Assumes an estimated job cost of $4720. Estimated advertised payment of $59 a month assumes third-party financing available for new customers at a 9.99% annual percentage rate for 132 months. Available to well qualified buyers on approved credit with $59 down payment. Not all buyers may qualify. Higher rates apply for buyers with lower credit ratings. LeafGuard is neither a broker nor a lender. Financing provided by third-party lenders. Expires 7/31/19. LeafGuard operates as LeafGuard of Oregon in Oregon under OR LIC # 223377

20  NORTHWEST 50 PLUS  MARION POLK  |  JULY 2019


Classifieds UNITS FOR RENT HUD SUBSIDIZED UNITS for people over 62 and/or persons with disabilities is currently accepting applications for our one bedroom waiting list. We are committed to providing equal housing opportunities. All utilities paid. Briarwood Manor, 643 Manbrin, Keizer, OR 97303, 541928-2545.

MISCELLANEOUS NEED A WILL? CALL Sal Catalano, “The Lawyer That Makes House Calls,” for an appointment in your home. 541-525-2884. Powers of Attorney-Advance DirectivesTrusts. www.CatalanoLawPC.com.

WANTED CASH FOR GOOD CONDITION reloading equipment & supplies. 541-905-5453.

DIABETIC TEST STRIPS WANTED. Paying top dollar! Free local pickup. Call Sharon, 503-679-3605 CASH FOR PRE 1980 sport & non-sport cards, model kits, comic books, pre 1960’s magazines. Private collector. 503-3137538. BASEBALL & SPORTS MEMORABILIA wanted. Buying old cards, pennants, autographs, photographs, tickets, programs, Pacific Coast League, etc. Alan, 503-481-0719.

HELP WANTED WOMAN CAREGIVER FOR ALZHEIMER’S CLIENT. Professional woman diagnosed with Alzheimer’s at 57 now 66. Night caregiver needed, possibly day relief hours also. $20.00/hr. 503-320-4023.

CLASSIFIED AD RATES

EQUAL HOUSING OPPORTUNITY

All real estate advertising in this magazine is subject to the Fair Housing Act which makes it illegal to advertise “any preference limitation or discrimination based on race, color, religion, sex, handicap, familial status, or national origin, or an intention to make any such preference, limitation or discrimination.” Familial status includes children under the age of 18 living with parents or legal custodians; pregnant women and people securing custody of children under 18. This magazine will not knowingly accept any advertising for real estate which is in violation of the law. Our readers are hereby informed that all dwellings advertised in this magazine are available on an equal opportunity basis. To complain of discrimination, call HUD toll-free at 1-800-669-9777. Toll-free for the hearing impaired is 1-800-927-9275.

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HOW TO SUBMIT AN AD: Mail your verbiage with payment to: Northwest50Plus, P.O. Box 12008, Salem, OR 97309 or email to classifieds@Northwest50Plus.com or call 1-877-357-2430.

*Punctuation not included in word count. Phone numbers count as 1 word. Ad must be in our office by the 6th of the month PRIOR to publication. Ads cover Vancouver, WA to Lane County.

Western Village Apartments • 1 Bedroom, 1 bath apartment $695 per mo/with 1 yr. lease • 2 Bedroom, 1 bath apartment $795 per mo/with 1 yr. lease • On-site laundry • Off-street parking • Non-smoking within unit • 55+ community CALL NOW

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MARION POLK  |  JULY 2019  NORTHWEST 50 PLUS  21


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YOUR HEALTH | CHRONIC CONDITIONS

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multiple sclerosis research shows promise By E R I K R O B I N S O N

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OHSU RESEARCHERS COLLABORATE ON POTENTIAL ‘GAME CHANGER’

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SCIENTIFIC BREAKthrough provides new hope for millions of people living with multiple sclerosis. Researchers at OHSU have developed a compound that stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord. The discovery, involving mice genetically engineered to mimic multiple sclerosis, published in April in the journal JCI Insight. MS is a chronic condition that affects an estimated 2.3 million people worldwide. In MS, the sheath covering nerve fibers in the brain and spinal cord becomes damaged, slowing or blocking electrical signals from reaching the eyes, muscles and other parts of the body. This sheath is called myelin. Although myelin can regrow through exposure to thyroid hormones,

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Top: In MS, the sheath covering nerve fibers in the brain and spinal cord becomes damaged, slowing or blocking electrical signals from reaching the eyes, muscles and other parts of the body. (Getty Images)

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researchers have not pursued thyroid hormone therapies due to unacceptable side effects. Although several treatments and medications alleviate the symptoms of MS, Dennis Bourdette there is no cure. “There are no drugs available today that will re-myelinate the de-myelinated axons and nerve fibers, and ours does that,” says senior author Tom Scanlan, Ph.D., professor of physiology and pharmacology in the OHSU School of Medicine. Co-author Dennis Bourdette, M.D., chair of neurology in the OHSU School of Medicine and director of the OHSU Multiple Sclerosis Center, says he expects it will be a few years before the compound advances to the stage of a clinical trial involving people. Yet the discovery provides fresh hope for patients in Oregon and beyond. “It could have a significant impact on patients debilitated by MS,” Bourdette says. The discovery appears to accomplish two important goals: ▶ Myelin repair with minimal side effects: The study demonstrated that the compound — known as sobetirome — promotes remylenation without

MARION POLK | JUNE 2019

the severe side effects of thyroid hormone therapy. Thyroid hormone therapy has not been tried in people because chronic elevated exposure known as hyperthyroidism harms the Meredith heart, bone and Hartley skeletal muscle. ▶ Efficient delivery: Researchers developed a new derivative of sobetirome (Sob-AM2) that penetrates the blood brain barrier, enabling a tenfold increase in infiltration to the central nervous system. “We’re taking advantage of the endogenous ability of thyroid hormone to repair myelin without the side effects,” says lead author Meredith Hartley, Ph.D., an OHSU postdoctoral researcher in physiology and pharmacology. Co-authors credited the breakthrough to a collaboration that involved scientists and physicians with expertise ranging across neurology, genetics, advanced imaging, physiology and pharmacology.

Potential as a ‘total game-changer’

One patient said the research could be a “total game-changer” for people

with MS. Laura Wieden, 48, has lived with multiple sclerosis since being diagnosed in 1995. The daughter of Portland advertising executive Dan Wieden, she is the namesake and board member of the Laura Fund for Innovation in Multiple Sclerosis, which funded much of the research involved in the study. “I am really optimistic,” Wieden says. “I hope that this will be literally a missing link that could just change the lives of people with MS.” Scanlan originally developed sobetirome as a synthetic molecule more than two decades ago, initially with an eye toward using it to lower cholesterol. In recent years, Scanlan’s lab adapted it as a promising treatment for a rare metabolic disease called adrenoleukodystrophy, or ALD. Six years ago, Bourdette suggested trying the compound to repair myelin in MS. Supported by funding provided through the Laura Fund and the National Multiple Sclerosis Society, the team turned to Ben Emery, Ph.D., an associate professor of neurology in the OHSU School of Medicine. Emery, an expert who previously established his own lab in Australia focused on the molecular basis of myelination, genetically engineered a mouse model to test the treatment.

A ‘Trojan horse’

With promising early results, researchers wanted to see if they could increase the amount of sobetirome that penetrated into the central nervous system. They did so through a clever trick of chemistry known as a prodrug strategy. Scientists added a chemical tag to the original sobetirome molecule, creating an inert compound called Sob-AM2. The tag’s main purpose is to eliminate a negative charge that prevents sobetirome from efficiently penetrating the blood-brain barrier. Once Sob-AM2 slips past the barrier and reaches the brain,

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Laura Wieden, 48, is the namesake and board member of the Laura Fund for Innovation in Multiple Sclerosis, which funded much of the research involved in the study. (OHSU/Kristyna Wentz-Graff)

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it encounters a particular type of brain enzyme that cleaves the tag and converts Sob-AM2 back into sobetirome. “It’s a Trojan horse type of thing,” Scanlan says. trig Researchers found that the treatment in mice not only triggered myelin repair, but they also measured substantial motor improvements in mice treated with the compound. “The mouse showed close to a full recovery,” Scanlan says. Scientists say they are confident that the compound will translate from mice to people. To that end, OHSU has licensed biotechnol the technology to Llama Therapeutics Inc., a biotechnology company in San Carlos, California. Llama is working to advance these molecules toward human clinical trials in MS and other diseases. Bourdette says even though it may not help his patients today, he’s optimistic the discovery eventually will move from the lab into the clinic. “Right now, what it means is hope,” he says. ☸

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