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Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes in drug metabolism and drug interactionsthe integral role of pharmacogenetics in metabolism-based drug-drug interactionsin vivo 8211 in vitro correlations (reversible, mechanism-based inhibition, induction)in silico approaches enabling structure-activity and structure-function studieshigh-throughput screening and GLP methods for evaluating drug interactions in vitrothe use of transgenic animal models to evaluate drug interactionsProviding helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.