PHARMACEUTICAL FOCUS//CAMs & Health Products
Innovative nutraceutical solutions Some of the most scientifically advanced active ingredients for nutraceutical and pharmaceutical applications are the result of Gnosis’ R&D and GMP manufacturing expertise. This advanced biotechnology company is represented in South Africa by Enna Industrial Ingredients (Enna).
A
lfred Musper, MD of Enna,
and are seeing positive results. There
recently hosted Marco Lattanzi,
is growing interest in our Quatrefolic
Gnosis’ area manager for the
product, which is a fourth-generation
EMEA region, in South Africa.
folate, as well as our VitamK7, S-adenosyl-
Pharmaceutical
Cosmetic Review
caught up with Lattanzi during his visit to find out more about the innovative products from Gnosis. ‘The core focus of our business is
methionine, and Mythocondro products,’ comments Lattanzi. Gnosis Quatrefolic is said to be the only form of folate that crosses the blood-brain barrier. This active ingredient is suitable for
developing raw materials for nutritional
use in nutraceutical products that address
and pharmaceutical products. We use a
consumers’ prenatal, lactation and cellular
fermentation process to produce APIs for
heath needs. According to results of a pre-
the pharma and nutraceutical markets; our
clinical in vivo study, Quatrefolic showed a
products are also used in the cosmetics,
plasmatic (6S)-5-MTHF concentration peak
veterinary and agricultural industries,’
(Cmax) about three times higher than that
Lattanzi explains.
of folic acid.
Although Gnosis is relatively new to South Africa, through its association with
Optimal, natural vitamin K2
Enna, the company is already making
Several studies indicate that vitamin K2 can
headway locally. ‘We’ve been promoting
act as a modulator in calcium metabolism,
our business in South Africa since 2015
taking it from the bloodstream where it
can result in calcium precipitation and ensuring it is deposited in the bones. Vitamk7 (Menaquinone 7), exclusively manufactured by Gnosis, is the active isomer of vitamin K2 with the highest bioavailability and longest half-life in the blood. The company performed clinical trials with successful results to determine Vitamk7’s efficacy. The first was an in vivo study on its effect on the gamma carboxylation of ostecalcin, while a second was a PGE-2 synthesis in bone forming osteoblasts in vitro study.
Non-animal Chondroitin Sulfate In line with its focus on innovation, Gnosis has in depth knowledge of global market demands. The company has noticed a rise in demand for plant-based alternatives to ingredients initially derived from animals. This is due to several reasons, including heterogeneity and batch to batch consistency. Gnosis’ Mythocondro is the first non-animal Chondroitin Sulfate (CS) produced using patented fermentationbased manufacturing process. ‘The result is a controlled, reliable and reproducible source of CS with high purity,’ Lattanzi adds. Clinically tested, well characterised and environmentally friendly, Mythocondro is set to address address the growing demand of an ageing population suffering from a variety of degenerative joint conditions. The ingredient also has anti-inflammatory activity and is proven effective in pain relief. •
Purveyors & Distributors of innovative Speciality Chemicals and Food & Beverage Ingredients. Serving the South African Personal Care, Cosmetics, Pharmaceutical and Food & Beverage Industries.
Enna Industrial Ingredients CC P.O. Box 1926 Randburg 2125 Phone: 011 791 1309 e-mail: info@ennaii.co.za www.ennaii.co.za
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| JULY 2017 | P C Review
Proudly represented by Enna II in South Africa
Enna Industrial Ingredients – www.ennaii.co.za Gnosis – www.gnosis-bio.com