nanotechnology
28 Issue 3 2018
Anton Paar introduces particle size analysers ANTON Paar’s portfolio for particle characterisation has been expanded greatly with three new laser diffraction instruments for particle size analysis (PSA). The PSA instruments are based on the laser diffraction principle and give information about the particle size distribution in dry powders as well as in liquid dispersions. The new particle size analysers, which have been recently acquired from the French company Cilas (Orléans, France), represent an excellent addition to the Litesizer product line. Anton Paar now offers measuring systems for a wide measuring range. This begins with particles of the size of a single water molecule and ends with pebble-sized particles. Whereas Litesizer is capable of measuring particle sizes from 0.3 nanometers to 10 microns in liquid samples, the PSA instruments expand this range to up to 2.5 millimeters in liquids and powders. The PSA product family consists of three instruments, namely PSA 990, PSA 1090, and PSA 1190. All three models can be operated in both dry and liquid modes. They are the only instruments on the market combining both possibilities in one single setup. This patented design eliminates the need for the operator to make any manual adjustments.
Switching between dispersion modes is done via the software with just a mouse-click, and no hardware changes, re-validations or re-alignments are necessary. Anton Paar’s PSA instruments stand out due to their unmatched robust design. The optical components and high-resolution detectors are mounted on a cast-iron base plate that keeps the system precisely aligned, even in the harshest environments, for example in the cement, mining and building materials industries. The patented multi-laser technology guarantees the highest accuracy and repeatability in a wide measuring range. These characteristics, together with full traceability of measuring results, set the basis for the future success of the PSA instruments in the pharmaceutical and cosmetics industries. All Anton Paar particle size analysers are calibrated according to the ISO 13320 and USP ‘429’ standards, and the software is 21 CFR Part 11 compliant. The PSA series is now part of the supreme service and support that is offered for all instruments in the extensive portfolio of Anton Paar. Additionally, further refinements of the PSA instruments for a complete portfolio integration are planned.
ANTON PAAR SOUTHERN AFRICA (PTY) LTD Tel: (011) 021 5165/6/7 Fax: 086 610 3908 info.za@anton-paar.com www.anton-paar.com
Zeta potential, molecular weight and particle size analyses THE SZ-100 Nanopartica from Horiba Scientific is a flexible analytical tool for characterising the physical properties of small particles. Depending on the configuration and application, this system can be used as a particle size analyser, as well as measurement of zeta potential, molecular weight, (MW) and second virial coefficient (A2). Typical applications for the SZ-100 include nanoparticles, colloids, emulsions, and submicron suspensions. Some of the main features include: • Particle size, zeta potential, molecular weight, and second virial coefficient all in one instrument
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Wide range of particle sizes and concentrations Particles size measurements at both 90° and 173° Multiple particle size measurement modes for working with small particles and weak scatters Small volume cells for both particle size and zeta potential
WIRSAM SCIENTIFIC JHB: (011) 482 1060 CPT: (021) 386 9020 DBN: (031) 709 0199 PE: (041) 365 2060 VT: (016) 931 1731 wirsamjb@wirsam.com www.wirsam.com
FX Nano for protein aggregation THE AccuSizer FX Nano SIS system is specifically designed to measure protein aggregation. The instrument meets and/or exceeds all requirements described in USP ‘787’ Subvisible Particulate Matter in Therapeutic Protein Injections. The results generated include particle size and concentration from 0.15 - 150µm - covering the official 10 and 25µm sizes, but with the sensitivity to investigate the more interesting submicron region. The new AccuSizer FX Nano SIS system consists of: • The SIS sampler modified to be able to accurately deliver sample volumes as small as 250µl • Two sensors, the LE400 and FX Nano sensor to measure 0.15 - 150µm Operation: • The 1.6mm sample probe is placed in the sample vial • The SIS syringe sampler draws the sample up through both the LE400 and FX Nano sensors for analysis • The sample flow can be reversed so that multiple passes of the sample
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are analysed in order to increase the number of particles measured to improve statistical validity At the end of the measurement cycle the sample is recovered in the original vial The AccuSizer software combines all collected data and reports particle count/ml
This unique system utilises the most advanced light extinction/scattering sensor technologies available to generate particle size and count data at smaller particle sizes and higher concentrations than any other system available. Size distributions are reported in up to 64 size channels. ANALYTICAL SOLUTIONS CC Tel: +27 (0)87 610 0900 (National) info@analyticalsolutions.co.za www.analyticalsolutions.co.za
Amnis imaging flow cytometers MICROSCOPY offers detailed cellular images and morphologic information, which are useful scientific tools for the study of cell function. However, the interpretation of microscopy images can be subjective, qualitative and laborious. Flow cytometry is excellent for quantitative phenotyping and yields statistically robust results by rapidly interrogating large numbers of cells. However, flow cytometry lacks any ability to image, so sub-cellular localisation and functional studies are difficult at best. By combining the speed, sensitivity and phenotyping abilities of flow cytometry with the detailed imagery and functional insight of microscopy, the ImageStreamX MKII and FlowSight instruments overcome the limitations of both techniques and open the door to an extensive range of novel applications. FlowSight imaging flow cytometer: • Capable: Applicable to every research discipline • Sensitive: Camerabased detection dramatically increases resolution over traditional flow cytometry
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Affordable: Smaller footprint with configurations for any lab focus and budget Powerful: Characterises populations by virtually any visual or fluorescent attribute
ImageStreamX Mark II imaging flow cytometer: • High-throughput: analyses thousands of cells per second at up to 60X magnification • Intuitive: Simple user interface with real-time plotting and gating • Adaptable • Boundless
MERCK (PTY) LTD Tel: 08600 63725 Fax: 0860 522329 labsupply@merck.co.za www.merckmillipore.com