A patient’s guide to hereditary prostate cancer
What is hereditary prostate cancer? The benefits of knowing if you have a hereditary mutation is critical in helping you and your doctor manage your cancer now and in the future. Hereditary cancer occurs when a gene mutation is passed down from parent to child. These mutations, like BRCA1/2, can cause normal cell-related functions to not work properly, increasing the likelihood of developing cancer. Knowing this information early on can help patients and their physicians understand if their cancer could be more aggressive, and can help inform initial treatment decisions. • If you have a gene mutation, your parents, children, and siblings could have a 50% chance of having the same gene mutation. • Other blood relatives (aunts, uncles and cousins) on the same side of the family are at risk of carrying the same gene mutation. • Genetic testing is the primary way to identify gene mutations, which could impact your medical management. • Remember, you can inherit a gene mutation from either your mother or your father, so it is important to look at both sides of your family.
Key: Actionable mutation No mutation
1 in 6 prostate cancers are hereditary1 How does genetic testing work? Genetic tests use next-generation sequencing technology to analyze small samples of blood or saliva to check for actionable mutations that may exist in every cell of your body – not just your cancer cells. Powerful genetic tests, like MyRisk® Hereditary Cancer testing, offer peace of mind by providing information to help your physician customize your cancer care. These genetic tests are the same type of tests that women with breast cancer and men and women with colon cancer routinely get to help customize their treatment plans.
How can genetic testing change treatment decisions? If you qualify for genetic testing, results can tell you if you have any mutations that could cause your disease to be more aggressive or increase your risk of developing a secondary cancer. Genetic testing can also help qualify you for new prostate cancer medications should your cancer spread or if you already have metastatic disease.
Benefits for newly diagnosed patients:
Benefits for advanced/ metastatic patients:
• Understand if you may have a more aggressive cancer
• Qualify for advanced therapies, like PARP inhibitors
• Guide initial treatment decisions, like "Am I safe for active surveillance?"
• Qualify for personalized cancer trials
• Inform family members of elevated cancer risk
• Understand your risk of developing a second cancer
1. Prevalence of Germline Variants in Prostate Cancer and Implications for Current Genetic Testing Guidelines Nicolosi et al. JAMA Oncol 2019.
Understanding if you're at risk for hereditary cancer starts with knowing your personal and family history If you can answer yes to any of the criteria below, you may be a good candidate for MyRisk® Hereditary Cancer Testing and should discuss it further with your healthcare provider. Metastatic prostate cancer High-/Very high-risk prostate cancer Gleason score 6 or 7 and one of the following:
Ashkenazi Jewish ancestry
1 family member with high-risk or metastatic prostate cancer
1 family member with ovarian cancer
1 family member with pancreatic cancer
1 family member with breast cancer ≤50 years old
2 family members on the same side of the family with breast or prostate cancer at any age
Patients with certain mutations and localized prostate cancer are2 :
6X
More likely to die from prostate cancer within 5 years
4X
More likely to develop metastasis within 5 years
2. Germline BRCA mutations are associated with Higher Risk of Nodal Involvement, Distant Metastasis, and poor Survival Outcomes in Prostate Cancer Castro et al. J Clin Oncol 31 (2013)
MyRisk® Hereditary Cancer test results Positive • A genetic mutation was found in 1 or more of the genes tested • You are at an increased of developing a second cancer • A summary of medical management guidelines will be provided specific to your gene mutation(s)
Elevated • No genetic mutation was found in the genes tested • You are at elevated risk for cancer based on an analysis of additional genetic markers, personal clinical risk factors, and/or your family's history of cancer • A summary of medical management guidelines will be provided based on your elevated risk
Negative • No genetic mutation was found in the genes tested • The common causes of hereditary cancer have been ruled out, but depending on family history of cancer, increased risks could still remain • Depending on your family history, medical management is usually based on general population screening guidelines; however, you should talk with your healthcare provider to determine if there are any changes in medical management that are right for you
Variant of uncertain significance (VUS) • A change in a gene has been identified • It is not yet known if the change is associated with increased cancer risk • Medical management based on personal and family history of cancer is recommended until more is understood about this specific change • If new information becomes available about a specific VUS detected in your testing, Myriad will contact your healthcare provider
Better answers about your prostate cancer MyRisk® testing is easy. If you qualify for testing, it can be done in the comfort of your home by providing a saliva sample, or at your providers office through a blood draw. Your sample will then be shipped to Myriad Genetics for analysis. We recognize that timely results matter and our testing is fast, with results typically available in under 2 weeks.
How can I get MyRisk?
Request a MyRisk test kit now!
Need help getting started?
1. Request a test kit below 2. Work with your provider to obtain a sample 3. Results available in around 2 weeks
From answering common questions about insurance or testing benefits to working directly with your doctor, our experienced customer support team is here for you.
Request test kit
How to contact us: Email: Urologytestsupport@myriad.com Phone: 513-216-4752
You have access to pre- and post-test consults with a patient educator, a board-certified genetic counselor, at no additional cost Pre-test education Speak with a certified genetic counselor at Myriad if you have any questions about genetic testing. Call 888-356-0630
Post-test education consult To help answer any questions that you may have about your result, go to my.myriad.com/consults. You will need your accession number located at the top of your result.
Genetic testing impacts lives “ It had affected my family as much as it had affected just me. My two daughters have since learned they are positive.” Ed Hoppe
“ I did get this gene mutation from my dad, there’s a 50/50 percent chance that my kids could have it.” Emily Hoppe
“ As a father, who has a son and a daughter where breast cancer and prostate cancer could clearly be a risk, germline testing was the answer." Tim Petracca
“ If something unusual is happening with a patient, they probably have something in their germline that is abnormal and should be a differential to think about getting genetic testing done." Kara Cossis, Advanced Practice Provider
Request a MyRisk Test Kit today!
Your ally in prostate cancer treatment Myriad has invested over 30 years in developing tests and solutions that help provide the best answers and care possible. Our tests are: •
ccurate: Myriad tests offer industry-leading accuracy so you can feel confident in the A results. From hereditary cancer to precision medicine, our tests are designed to give providers and patients the most accurate answers possible.
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Actionable: Myriad makes genetic testing simple with clear, actionable results. We create easy-to-understand reports to ensure that both patients and their providers can use the information to guide treatment options based on national medical guidelines.
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Secure: Myriad believes that results and genetic information belong to the patient. We take multiple steps to ensure that the security and privacy of patient data is not comprised, and we believe that patients should be in control of their information.
Testing is affordable
Medicare covers at 100%
>93% of patients pay $0
Financial assistance available
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