August 19, 2011
MEDICAL UNIVERSITY of SOUTH CAROLINA
Vol. 30, No. 1
InsIde AntioxidAnt Benefits
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Dr. Ashley Cowart researches how olive oil can reduce type 2 diabetes.
Above, Dr. Jay Morris studies green tea polyphenols. Right, Dr. Michael Wargovich visits Kankan, Republic of Guinea, where he collected 15 medicinal plants.
RoBotiC suRgeRy
Rooting out natural treasure By dawn Brazell Public Relations
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ndiana Jones, move over. MUSC has its own globe trotter searching for international finds. With a treasure trove of barks, plants and fruit extracts stashed on shelves in his laboratory, Michael J. Wargovich, Ph.D., loves roaming the globe in pursuit of natural plants and products that may hold clues to prevention and treatment of cancer. The ethnobotanist, who recently finished submitting six grants in two weeks, is a professor of cell and molecular pharmacology at MUSC, and has a wait list of students who want to work in his laboratory. Arriving at MUSC four years ago after 15 years at MD Anderson Cancer Center in Houston, Wargovich has been a chemoprevention researcher for more than 20 years. He started with pharmaceutical drugs and then moved to dietary compounds after noticing interesting associations with what people eat in other
Researchers Vondina Moseley, Dr. Jay Morris, Becky Weber and Dr. Michael Wargovich strike a pose in their lab. areas of the world and lower incidences of cancer. His work studying West African plants for specific kinds of anticancer activity, especially COX inhibition, on colon cancer cell lines recently was featured in the latest National Cancer Institute’s overview of promising research in complementary and alternative medicine. Wargovich’s interest in ethnobotany got a boost when he went to the Republic of Guinea, West Africa in 1999-2000 because
of research being done by his wife, Joan Cunningham, Ph.D., a breast cancer researcher and epidemiologist who now works at MUSC. While there, he met a traditional healer who had a detailed book of all the medicines they had derived from natural plants in that region. “I felt like Indiana Jones who had been given the key to the city. I asked them if it would be possible to get some of those plants, and they said sure, no problem, and that started it. We brought some of those plants back,“ he said pointing to bins stored in his lab. “One plant we found has a natural pain reliever and those are strongly associated with reduced risk for cancer.” The hope is that some of these natural compounds can reduce inflammation with the effectiveness of nonsteroidal antiinflammatory drugs but without the toxicity and side effects that have required the drugs to be pulled off the market or be limited in use because of side effects. The bark of the See natural on page 8
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Dr. Harry Clarke reconstructs a new bladder using the da Vinci Surgical System. 2 Meet Sarah Currents
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t h e C AtA ly s t online http://www. musc.edu/ catalyst