MUSC Catalyst 6-19-2015

June 19, 2015

MEDICAL UNIVERSITY of SOUTH CAROLINA

Vol. 33, No. 41

Inside Captain pride award

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photo by NOAA

More than 25 years after Hurricane Hugo, MUSC is bracing for the next big storm.

Experts say it’s only a matter of time.

‘It only takes one storm to make a bad hurricane season’

By J. Ryne Danielson Public Relations

I

t’s been over a quarter century since Hurricane Hugo slammed into the South Carolina coast just a few miles north of Charleston, killing 35 people and leaving upward of 100,000 homeless. At the time, Hugo was the costliest storm in U.S. history, though it was soon supplanted by Andrew, Katrina and a host of other billion dollar storms.

Hurricane season began June 1 and one named storm, Ana, has already swept up the Carolina coast. The Weather Channel recently listed Charleston as “vulnerable and overdue” for another big storm and MUSC is taking that warning seriously.

The National Oceanic and Atmospheric Administration predicts six to11 named storms for the 2015 season, with three to six of those being hurricanes and up to two being major hurricanes, Category 3 or higher. This would make the season slightly

LIKE US

calmer than usual, however that doesn’t mean we’re off the hook.

“It only takes one storm to make a bad hurricane season,” said Jennifer Taylor, business manager for MUSC Risk Management. “That’s why preparation is key. We learned with Gaston in 2004 that we might not have a lot of time to get ready.

That storm formed right off our coast and it formed pretty quickly.”

Gaston made landfall Aug. 29, just north of Charleston. Originally classified a tropical storm, it was later reclassified a Category 1 hurricane with sustained winds of 75 mph. Even with a relatively small storm like Gaston, damage to MUSC’s campus was extensive.

“We had roughly a million dollars in wind and rain damage to some of our buildings,” Taylor said. “It did a lot more damage than we thought.”

For an organization as large and complex as MUSC, staying ahead of a storm is no

Medical University of South Carolina — FOLLOW US

See Storm on page 6 @ Catalyst_MUSC

MUSC librarian recognized for sustainability efforts in community.

GlObal health

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Five faculty receive seed funding to conduct global research.

3 Around Campus 5 Meet Donna 10 Wellness t h e C ata ly s t Online http://www. musc.edu/ catalyst

2 The CaTalysT, June 19, 2015

PeoPle

Around Campus

evenTs

Joe Helpern

Art sale benefitting kids

Joe Helpern, Ph.D., director of the Center for Biomedical Imaging, has been invited to participate as a reviewer for President Barack Obama’s White House BRAIN Initiative. The BRAIN Initiative will help revolutionize the understanding of the human brain through the development and application of new technologies.

The Friends of MUSC Children’s Hospital will host a fine art show and sale on Kiawah Island on July 10 at the oceanfront Sandcastle Community Center, 1 Shipwatch Road, Kiawah Island. A portion of the event’s proceeds will be donated to support the MUSC Shawn Jenkins Children’s Hospital and Women’s Pavilion. The one-day event will feature original works of nine Charleston artists: Jennifer Black, Susan Colwell, Laura Lloyd Fontaine and others.

To preview the show, visit: http:// www.HaganFineArt-MUSC.com. For information, contact Kelly Hewitt at hewitt@musc.edu, 792-2624.

Leah Ramos

Leah Ramos, R.N., 9East NeuroIntermediate Unit nurse manager, was named among 25 outstanding caregivers across the U.S. who will receive the American Association of Critical-Care Nurses 2015 Circle of Excellence Award. Ramos was recognized for achieving outcomes in the care of high acuity and critically ill patients and their families.

Anton Gunn

Anton Gunn, Chief Diversity Officer, has joined the Community Catalyst’s

Editorial of fice MUSC Office of Public Relations 135 Cannon Street, Suite 403C, Charleston, SC 29425.

843-792-4107 Fax: 843-792-6723

Editor: Cindy Abole catalyst@musc.edu Catalyst staff: Mikie Hayes, hayesmi@musc.edu Dawn Brazell, brazell@musc.edu J. Ryne Danielson, daniejer@musc.edu Helen Adams, adamshel@musc.edu Sarah Pack, packsa@musc.edu Jeff Watkins, watkinsj@musc.edu

photo provided

Pediatric residents and faculty teammates Drs. Nick Galan, from left, Adebowale (Debo) Odulana, John Amadon, Jenny Calder, Liz Wallis and Terry Dixon squared off June 16 as part of the Department of Pediatrics’ 18th Annual Quiz Bowl competition. Each year, residents compete with faculty in answering medical-related questions. board of directors.

Gunn, who joined MUSC’s leadership team Jan. 12, previously worked as director of External Affairs for the U.S. Department of Health and Human Services.

Gunn’s relationship with the Community Catalyst organization began in 1996 where he participated in advocacy training.

The Catalyst is published once a week.

Paid adver tisements, which do not represent an endorsement by MUSC or the State of South Carolina, are handled by Island Publications Inc., Moultrie News, 134 Columbus St., Charleston, S.C., 843-849-1778 or 843-958-7490. E-mail: sales@moultrienews.com.

Katherine Twombley

Katherine Twombley, M.D., assistant professor of pediatrics and medical director of the Pediatric Kidney Transplant Program, is the 2015 John R. Raymond Fellowship winner.

She will be presented the award by the Women Scholars Initiative/ ARROW program at a formal reception June 25.

Trick Shot Golf Show Enjoy world-renowned trick shot artist and paraplegic golfer Dennis Walters with co-star Super Dog Bucky from 10 a.m. to 12 p.m., Saturday, June 20 in this precision golf show. Admission is free.

Food truck will be available. Register preferred at www.charlestonfirsttee.com.

For information, call Susan Callahan, callahsu@musc.edu.

Write for Postdoc Newsletter Postdoc Press is the official MUSC Postdoctoral Association Quarterly Newsletter. Share your writing skills for its summer issue. Email Vitria Adisetiyo, Ph.D. at adisetiy@musc.edu.

Repairs to Jonathan Lucas Patient Garage As part of the ongoing efforts to maintain our parking facilities, waterproofing and masonry repairs to the Jonathan Lucas patient parking garage are scheduled until September.

This project will take 77 of the 365 spaces in the garage out of service for two to three months.

In order to minimize inconvenience to our patients and visitors, efforts to reduce unauthorized employee parking in this patient facility are underway.

Beginning June 15, employees entering the Jonathan Lucas garage during the patient day may be asked to present their OPM parking authorization.

In the absence of current OPM authorization, employees will be redirected to their personal parking locations. Employees authorized to park in the garage at night and on weekends should make every effort to vacate the garage prior to 8:30 a.m.

Monday through Friday.

The CaTalysT, June 19, 2015 3

MUSC librarian praised with environmental award Staff Report Teri Lynn Herbert, assistant professor and reference librarian, Department of Library Science and Infomatics, was recognized with the 2015 Captain Pride Award from Community Pride, Inc. of Charleston County. The award was presented at the group’s 49th annual awards luncheon May 15.

Vonie Gilreath, chairman of the Pride Board of Directors and Charleston County Councilman Herb Sass presented the award to Herbert.

Sass read Herbert’s nomination statement: “Teri Lynn Herbert has helped the Lowcountry by her sustainable lifestyle, her lifetime dedication to others and her generous contribution of time and effort to several environmentally friendly organizations.

She really lives the sustainable low– carbon footprint lifestyle. She used reusable bags before they became

popular, drives a hybrid car, repairs items instead of throwing them away, conserves energy at home, the list goes on. At work she is the recyling chair, appointed by the president, for the MUSC library.

There she helps others understand why it is important to recycle and how to do it right. She makes an extra effort to conserve energy at work too. She encourages others to re-use and educates them on how to go about it. She coordinates garage sales for friends and helps them as needed and makes sure all items left over from the garage sales are donated to thrift stores. Teri Lynn inspires us to live sustainably by causing the least harm to the environment as possible and saving natural resources. In a very quiet and humble manner, Teri Lynn has made a very positive impact on our community and environment.”

Herbert was among 10 individuals, businesses, governments or civic organizations that were recognized by

photo provided

MUSC librarian Teri Lynn Herbert, right, receives a Captain Pride Award from Community Pride’s Vonie Gilreath, center, and Charleston County Councilman Herb Sass at the May 15 luncheon. this organization for their excellence in improving the environment.

Herbert admits that her focus on improving the environment has been a lifelong commitment.

“I credit my parents with my concern for reusing, recycling, repairing and caring for the environment. They were excellent role models for me,” she said with a smile.

MUSC professor placed on Fulbright specialist roster

By Kevin Wiley Center for Global Health

C

ongress recently announced its 21st Century Cures initiative to accelerate the pace of cures and medical breakthroughs in the U.S. The goal is to promote an environment through which innovation is fostered among unlikely partners in government, academia and industry. It is now beginning to take hold. The American Medical Association has provided input on areas that, from their professional perch, need to be reformed. Other groups are weighing in to provide vital contributions to future groundbreaking research and global health threats.

Health care professionals, like Patricia Coker–Bolt, Ph.D., bring a hands-on, constructive perspective to informing global health care research as a result of their backgrounds and experience. Coker–Bolt is an associate professor in the Division of Occupational Therapy in the College of Health Professions, who has been traveling to Africa on medical missions trips for more than seven years. Coker–Bolt received a faculty pilot grant in 2014 from the MUSC Center for Global Health to conduct research on constraint induced movement therapy in children in Ethiopia. As a result, she was published in prestigious international journals

photo provided

Occupational Therapy assistant professor Dr. Patrician Coker-Bolt won support from the Fulbright Specialist program to continue her therapy work with children in Africa.

and built potential long–term partnerships.

After some encouragement from Emily Moore, Ed.D., a highly regarded professor and recently retired associate dean at CHP, Coker–Bolt applied to the competitive Fulbright specialist program. Coker–Bolt

also received support pursuing the Fulbright position from the Center for Global Health.

The Fulbright Specialist program, sponsored by the Bureau of Educational and Cultural Affairs at the Department of State, provides research professionals with short-term training oriented exchange opportunities in more than 155 countries.

Fulbright specialists are chosen based on academic merit and leadership potential to engage in projects related to environmental issues, food security, public health, education and other challenges that require innovation, creativity and knowledge that transcend all borders, according to the Fulbright website.

Coker–Bolt recently received placement on the prestigious Fulbright specialist roster — a testament to her growing stature in the field of physical and occupational therapy. She will be in esteemed company as a Fulbright alumni. Among the past Fulbright recipients are 53 Nobel Prize awardees, 39 MacArthur fellows and 82 Pulitzer Prize winners. With the knowledge gained from completing the Fulbright program, Coker–Bolt will continue to develop relationships with international partners to offer sustainable programs in low–resource settings.

See Fulbright on page 11

4 The CaTalysT, June 19, 2015

Research Impact Dr. Laura Kasman q Associate Professor,

Department of Microbiology & Immunology q NIH R25 award: $238,863 (Year 1 Cost) q February 1, 2015 to January 31, 2020

Dr. Cynthia Wright q Associate Dean for

Admissions and Career Development, College of Graduate Studies

Laura Kasman, Ph.D., associate professor, Department of Microbiology and Immunology, and Cynthia Wright, Ph.D., associate dean for Admissions and Career Development in the College of Graduate Studies, received an R25 award to create the MUSC Post-baccalaureate Research Education Program (PREP).

PREP is designed to provide under-represented minority and disadvantaged students with an intensive one-year biomedical research and mentoring experience with which to acquire the skills, habits and mindset it takes to be successful in graduate school and life-long scientific careers.

This five-year research study will support five to six promising individuals per year through an intensive, mentored research and professional development program at MUSC. The program will leverage the established Initiative for Maximizing Student Development program as well as our active Multicultural Graduate Student Association to provide role models that support identity development as scientists and long-term support systems for our scholars. PREP Programs are funded by the NIH

at selected universities around the United States with the goal of increasing the diversity of the biomedical research workforce to be better able to address health disparities.

Dr. Xue-Zhong Yu q Professor and Department of Microbiology & Immunology q NIH R21 Award $130,500 (Year 1 cost) q February 2015 to January 2017

Xue-Zhong Yu, Ph.D., professor, Department of Microbiology & Immunology, plans to study “Control of GVHD and Leukemia Relapse by Targeting Cell Metabolism.”

Bone marrow transplantation offers great promise for the treatment of blood-related diseases or cancers (e.g. leukemia). However, the graft-versus-host disease (GVHD) procedure has a major complication, which is induced by donor T-cells that recognize disparate antigens and cause tissue injuries in the recipient/patient.

Recent research indicates that activated T-cells and cancer cells share a dominant metabolic pathway to acquire sufficient energy by consuming glucose, known as aerobic glycolysis.

This project focuses on T-cell metabolism under BMT and to identify or validate potential metabolic molecules for controlling GVHD as well as leukemia recurrence.

Jenna L. McCauley, Ph.D., assistant professor, Addiction Sciences Division in the Department of Psychiatry & Behavioral Sciences, was awarded a K23 to conduct a study titled, “Reducing Prescription Opioid Misuse: Dental Provider Intervention Development.”

Over the past 15 years, the U.S. has experienced a dramatic rise in prescription opioid–related overdose, treatment admissions

Dr. Jenna L. McCauley q Assistant Professor, Addiction Sciences Division, Department of Psychiatry & Behavioral Sciences q NIH K23 Award: $169,430 (Year 1 cost) q February 1, 2015 to January 31, 2020

and death. Recently, the U.S. Health and Human Services Secretary announced a targeted initiative to address this epidemic that includes providing health professionals with training and resources to assist them in making informed prescribing decisions.

Dental providers are the second leading prescriber of immediate release opioids. The limited existing evidence suggests that most dentists may be unaware of the risks of opioid misuse, abuse and diversion among their patients, as well as how best to mitigate these risks.

McCauley’s NIDA–sponsored career development award provides her with the training and mentorship necessary to examine patterns of opioid prescribing, prescribing behaviors and potential gaps in risk mitigation training among dentists. Findings from these studies will directly inform the development and pilot randomized controlled trial of an educational intervention that aims to increase dentists’ awareness and use of recommended opioid prescribing risk mitigation strategies — including patient education, screening for opioid misuse, and accessing their state’s prescription drug monitoring program data.

The Research Impact column showcases the research community’s grant activities. For information about awards, visit the Office of Research & Sponsored Programs’ Monthly Reports at http://academicdepartments.musc. edu/research/orsp/reporting/ or email stories to research@musc.edu.

The CaTalysT, June 19, 2015 5

Meet Donna

Donna Gallahorn, R.N. Department Pediatric Sickle Cell Clinic How you are changing what’s possible at MUSC As a member of the Ambulatory Education Resource committee, I share continued knowledge and educational opportunities with my peers.

How long at MUSC 24 years Children and their names Husband, Robert; daughter, Sarah, 21 and son, Jake, 18; and yellow lab, Abby Three words that best describe MUSC’s Sickle Cell Clinic Education, knowledge and research Favorite summer memory Yearly trip with my husband and friends to Key West

Happy Father’s Day from the Hunnicutt team!

Visit www.EdHunnicutt.com

Favorite quote You are kind; you are smart; you are important. (Everyone needs to feel this way) — from the movie, “The Help”

IP02-1327733

Best part of living in Charleston Amazing boating and fishing

843.270.0292

6 The CaTalysT, June 19, 2015

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easy task. “We’re constantly monitoring the forecast, communicating with our local National Weather Service and with the Charleston County Emergency Management division. As soon as it looks like a storm is coming our way, we brief senior leadership and begin coordinating with our Engineering and Facilities folks to begin deploying sandbags and floodgates, with Public Safety and with the Emergency Preparedness department on the hospital side.”

Brian Fletcher, R.N., Disaster Preparedness program manager, and Kathy Lehman–Huskamp, M.D., director of Emergency Preparedness, are responsible for hospital operations during a storm.

“Beginning on June 1, we’re watching the tropical Atlantic and Caribbean basin every day,” Fletcher said.

“What we do is dependent upon the characteristics of the storm and what the projections are. We do tropical storms and Category 1 hurricanes very well here, because we have had so many experiences with that level of storm.”

But, he cautioned, there is always a level of uncertainty.

“Every storm is different,” Taylor agreed. “Let’s say it’s a tropic storm that’s going to dump a ton of rain.

That would mean different preparations for us than a Category 3 or Category 4 storm.”

“With any storm, our biggest concern is water rather than wind,” Fletcher said. “That’s always a challenge

Sherman Paggi, Library

On Sept. 21, 1989, Hurricane Hugo made landfall at McClellanville, 30 miles north of Charleston, leaving $10 billion of destruction in its wake. At the time, it was the costliest storm in U.S. history. photo provided

here being on the peninsula.”

“And there is no good way to predict the level of storm surge resulting from a storm until the storm is there and you measure it,” Lehman–Huskamp added.

The strength of a storm, as well as its speed, the level of the tide, the amount of rainfall, the shape of the ocean floor and the elevation of infrastructure all contribute to how damaging storm surge might be in a given scenario. Flood waters can shut down bridges and make many roads into and out of Charleston impassable.

“We are a community of bridges,” Fletcher said. “If all of our bridges are closed, we’re essentially separated into 18 islands. Knowing what you’re going to do when that happens is important. When we have a storm that threatens our ability to get staff in, we move into our emergency operations plan and activate our response teams.” respOnse teams Essential personnel are organized into two teams, A and B. Team A reports for their duties just ahead of the storm and stays until Team B can come in to relieve them after the storm has passed.

“We just had a tabletop exercise to review our emergency operations plan,” Lehman–Huskamp said. “We drilled a Category 3 hurricane hitting the Charleston area. As with any plan, you can’t just put it down on paper and expect that it remains current.

You have to practice and adapt. We set a timer for each day, starting at day 5 and had representatives from each of the 20 hospital support functions walk us through their priorities for each day. We identified a few gray areas, like our pharmacies’ need for portable sinks, and are taking steps to fix those. We have already ordered additional sinks as a result of the tabletop.”

“That’s the purpose of exercises,” Fletcher explained.

In addition to plans and exercises, Fletcher stressed that it is important to learn from experience and to be

prepared for the unknown. “Disasters do not follow plans,” he said.

“For example,” Lehman–Huskamp said. “One interesting thing we learned from the recent ice storm is to organize call trees by where staff members live, which is pretty important for an area that’s so dependent on bridges. If you know that folks in West Ashely are going to have a really hard time getting in, then having them cluster together in a call tree for emergency notifications is effective.”

Communication is critical during any emergency.

From call trees, email, pagers and text messages to the Government Emergency Telephone Service — which gives emergency personnel priority access to mobile networks — MUSC has access to multiple, redundant lines of communication during a storm or any other disaster. There are also system-fail landline phones and portable radios, including a radio-based email service and a microwave radio link between MUSC and South Carolina Educational Television, the statewide PBS and NPR affiliate, which allows critical computer services to remain active during a storm.

“If all else fails, we’ll hold town hall–type meetings to disseminate information,” Fletcher said. why nOt just evaCuate?

“Some folks say, ‘you need to start evacuating your facility five days away.’ Well, five days away, the storm’s still down in Cape Verde,” Fletcher said. “How do you justify moving patient populations at that point?”

In the event of a major storm tracking toward Charleston, Taylor added, the hospital discharges as many patients early as possible. “We certainly try to limit our census and discharge as many folks as we can but, for many critically–ill patients, evacuating would be more of a risk than sheltering in place.”

For some patients, such as many of those in the Institute of Psychiatry, there are additional

See Storm on page 7

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Continued from Page Six

complications: “Some of the folks from IOP would have to be transported by law enforcement because they’re under judicial order,” Fletcher said. “Many have no place else to go.”

So, in the face of an oncoming storm, while other residents of Charleston might be heading for the hills, many MUSC employees will be heading into work.

“MUSC has a duty to care for our patients,” Fletcher added. “However many patients we have, we would need enough staff here to care for them.”

In addition, MUSC coordinates with Roper and other hospitals in the area to support the community as a whole.

“When we are in a disaster scenario, we all operate as one facility,” Fletcher said.

“We always put patients first — whether they’re our patients or not.” publiC safety “MUSC has the population of a small town,” said Lt. Layne Thompson, Public Safety training manager. “We’re a city within a city. During a storm, Charleston Police will have myriad issues to deal with throughout their jurisdiction — Public Safety provides MUSC with a police force that can focus on Hospital and University–specific problems.”

Thompson said Public Safety’s primary role is to maintain order during and immediately following a storm, to ensure the campus is secured, free of potential flying debris and to respond to any emergencies that may arise.

Thompson recently helped create the MUSC Notify app for iOS and Android phones and tablets. “The app has a wealth of information to help employees and students prepare for hurricane season,” he said. However, he cautioned: “The app is a starting point. Everyone should be familiar with their unit’s operations plan and the hospital’s severe weather plan. I think the biggest issue we have is a lot of people in the community haven’t been here for a major storm.

Everyone needs to prepare.”

“It’s not a matter of if it’s going to happen; it’s a matter of when does it happen?” Fletcher said. “We all have to prepare for those inevitabilities.”

At any given time, the hospital has approximately 24 hours’ worth of supplies on the shelf, but Disaster Preparedness has coordinated with

Sherman Paggi, Library

vendors to have additional supplies ready and waiting in Charlotte, outside the disaster zone.

“It would take them four hours or less to get it to us,” Fletcher said. “And we’ve actually tested that.

“It’s important that we understand our capabilities, but also our hazards and vulnerabilities and to prepare based on those,” he continued. “To give an example, one of our biggest vulnerabilities, until about two years ago was loss of electrical power, particularly in the Main Hospital. While our generators were moved out of the flood plain after Hugo, the automatic transfer switchers still remained on the first floor.

We were able to obtain federal grant funding to assist us in putting in new generators and moving our ATS switches out of the flood plain, as well as moving boilers and other equipment that we need to sustain ourselves during a storm.

“Thanks to the Sabin Street Project, we’ve almost quadrupled our power generation capacity. We even have

the capacity to maintain heating, ventilation and air conditioning systems on emergency power. Without that capability, I can tell you, it gets very hot in these buildings very quickly, particularly right after a storm.”

Being prepared for a storm is critical for MUSC employees and the patients they serve, as well as the Charleston community as a whole.

“Folks don’t realize, MUSC is one of the largest employers in the area,” Fletcher said. “If we lost this asset, the economy would take a big hit. We saw that in New Orleans after Katrina — the loss of Charity Hospital and Mission having to close for quite some time and other hospitals in the area like Tulane — all of those hospitals suffered significant damage. And the people that staffed those hospitals suffered significant damage. Many had no alternative but to move.

“It’s extremely important to realize the impact of closing or evacuating a facility — what that would do to us economically.

It’s mind–boggling. Not to mention that our local community would have no place to turn for medical care without traveling significant distances. The next closest trauma center is in Columbia or Savannah. We are the only transplant hospital in the state. So, the entire state loses if we cannot continue our operation.

“That’s why it’s extremely important we have preparedness plans in place.”

Fletcher, Lehman–Huskamp, Taylor and Thompson all stressed the necessity for preparation, on both an institutional and individual scale. are yOu ready?

“Everyone needs to understand how vulnerable an area we live in,” Fletcher said. “Everyone needs to have a plan — not just for hurricanes, but other hazards. Everyone needs to have a child-care plan, pet–care and elder–care plan. Everyone needs to have a stock of

See Storm on page 11

8 The CaTalysT, June 19, 2015

Global Health faculty pilot grant recipients announced

By Kevin Wiley Center for Global Health Four MUSC faculty members, representing diverse disciplines, received Center for Global Health Faculty Pilot Grants of up to $20,000 for a 12–month period. These grants were offered through a competitive scoring process comparable to the National Institutes of Health scientific peer review.

MUSC Center for Global Health awards seed funds every year to stimulate research in low– and middle–income countries with the larger goal of enabling investigators to leverage preliminary findings and data to become the basis fora competitive extramural research grant application. The peer–review process yielded the following grant awardees.

“Lipidomic profile and contaminants associated with pansteatitis in South Africa” Guillette has worked regularly in South Africa for the last 3-1/2 years conducting and publishing research on the impact of toxic chemicals, either singly or as complex mixtures with other stressors, on the health of individuals or ecosystems. According to the World Health Organization (WHO), pollution or environmental factors are the root cause of death, disease and disability in the developing world, where it is estimated to cause 25 percent of death and disease globally. Guillette and his colleagues are concerned with the impacts not only to tropical fauna but humans as well. Guillette’s project seeks to determine the relationship between disease occurrence and exposure to toxicants in fish at different trophic levels; determine the plasma lipid profiles of fish with varying states of pansteatitis; and compare lipid profiles in fish species at different trophic levels to determine similarities in fish from another experimental study.

Guillette and colleagues will examine an inflammation disease, called pansteatitis, occurring in wildlife that include tilapia, sharp–tooth catfish, and Nile crocodiles. Guillette’s research

Louis Guillette, Ph.D.

Azizul Haque, Ph.D.

Director, Marine Biomedicine & Environmental Sciences Center, SmartState Endowed Chair Professor, Department of Obstetrics and Gynecology College of Medicine

Associate Professor, Department of Microbiology & Immunology College of Medicine

will be the first to fully characterize the lipidome and lipid–related pathways of health and diseased fish to provide insight into the causes, etiology and anthropogenic impact on the local environment and human health. Also contributing to this study are MUSC graduate studies students Theresa Cantu and Jacqueline Bangma — both of whom received global health trainee travel grants from the MUSC Center for Global Health.

Guillette wrote that “a wider study

examining other wildlife and humans is essential,” pending determination of similar lipid signatures, “and would be the basis for a proposal to the National Institute of Environmental Health Sciences. The proposal characterizes this disease as well as examine potential human health related effects.

“Immune regulation by arsenic” According to Haque, current estimates show that 100 million people are exposed

to dangerous levels of arsenic in drinking water globally, mostly in Asia and parts of South America. Exposure has been linked to numerous neurological, cardiovascular, dermatological and respiratory issues. In this study, Haque and colleagues will test whether exposed patients in Bangladesh modulate immune responses through differential antigen processing and presentation.

The researchers will also test whether patients exposed to arsenic have challenged immune responses through altered antigen processing, induction of autophagy and exhaustion of T–cell proliferation. Haque’s project is tailored to patients in Bangladesh because of the exposure rates: an estimated 46-57 million people are exposed to very high concentrations of arsenic, according to the World Health Organization. As a result of this study, Haque and colleagues will seek out therapies for patients acutely and chronically exposed to arsenic. Abigail Lauer, research associate in the Department of Public Health Sciences, will serve as co–investigator.

“The goal of this proposal is to investigate whether environmental arsenic exposure perturbs immune responses in humans,” wrote Haque. “It aims to examine and compare antigen processing and presentation by antigen presenting cells from patients exposed to arsenic versus healthy individuals and to investigate whether arsenic exposure triggers differential induction of cytokines/growth factors, apoptosis/ autophagy and immune dysfunction in the hosts.”

“Genetic analysis of children and families with retinal dystrophy in Costa Rica”

Mae Millicent Peterseim, M.D.

Suparna Qanungo, Ph.D.

Associate Professor, Department of Ophthalmology College of Medicine

Dual Principal Investivator Research Assistant Professor, College of Nursing

One in 5,000 people globally are affected by retinal dystrophies which lead to blindness. Retinal dystrophies are well studied in the U.S., and genetic analyses of these patients are routine.

Clinical treatment trials are promising and the Storm Eye Institute at MUSC is involved in this research. Peterseim found that children in Costa Rica lack the opportunity for genetic analysis and chose to focus her research efforts on a

See Global on page 12

The CaTalysT, June 19, 2015 9

Road Closure affects commute from June to August

PUBLIC NOTICE

Magnet Recognition Program® Site Visit

Staff Report The city of Charleston will be undertaking a large, long term project to improve the flooding in the SpringFishburne drainage basin area.

This project, which consists of five phases in total, (with the completed CrossTown project being Phase 1), is now kicking off Phase 2. As part of the project, the work requires extensive drainage piping rework in areas north of the Crosstown. The MUSC campus will be affected directly as the project progresses over the next few months.

However, Sheppard Street is closed from June 8 to some time in August.

This closure will affect access to Rutledge Tower from the Crosstown, especially staff and patients coming in from Mount Pleasant and from the north via I–26.

This closure is expected to last for approximately two months.

This above map has Sheppard St.

q MUSC has applied to the American Nurses Credentialing Center (ANCC) for the prestigious designation of Magnet. The Magnet designation recognizes excellence in nursing services. q The site visit will take place July 20 to July 23, 2015. q Patients, family members, staff and interested parties can participate in the evaluation process. Anyone who would like to provide comments are encouraged to do so. Anyone may send comments via e-mail, fax and direct mail. All phone comments to the Magnet Program Office must be followed up in writing.

Your comments are confidential and never shared with the facility. If you choose, your comments may be anonymous, but must be in writing.

Comments must be received by July 10, 2015

map provided

indicated in red and the possible routes that can be taken as possible detours to get around the closure and to get to Rutledge Tower.

Address: American Nurses Credentialing Center (ANCC) Magnet Recognition Program Office 8515 Georgia Ave., Suite 400 Silver Spring, MD 20910-3492 (866) 588-3301 (toll free) — (301) 628-5217 (fax) or magnet@ana.org

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10 The CaTalysT, June 19, 2015

Make sure summer doesn’t become a pain: use sunscreen skin. Thus, if one develops a exposure. burn after 10 minutes of direct q Sun safety tip #6 — Try sunlight without sunscreen, and avoid the sun during the but after 300 minutes with hours of 10 a.m. to 4 p.m. sunscreen, the SPF would This is typically the time be approximately 30. For of day when one’s shadow most people, an SPF of 30 is is shorter than his or her sufficiently strong enough to height. The vast majority of adequately protect the skin.

UV light strikes the earth’s q Sun safety tip #3 — Choose surface during these hours. a sunscreen with an active If one needs to be in direct ingredient of “Zinc oxide” or sunlight in midday, strict sun “Titanium dioxide.” Decades protection strategies should Susan Johnson ago, use of these types of be employed. sunscreens led to the “solid Wellness Events white nose” appearance that would q June Monthly Mindful Challenge — now be cosmetically unacceptable for Protect yourself from excess exposure to many. However, now sunscreens with the sun: Make sunscreen part of your these ingredients have micronized morning routine. Begin by taking the particles to make the appearance more challenge’s first survey at http://tinyurl. inconspicuous, similar to other chemical com/pcojr4f. A link to the final survey based sunscreens. The benefits of using will be sent at month’s end to those who Zinc and Titanium based sunscreens take the first survey. over most chemical sunscreens include a q Fit Family Challenge — MUSC is a wider range of UV protection and lower partner in this 8–week program where risk of contact allergy. residents are challenged to get out and q Sun safety tip #4 — Aim to apply get active until June 29. MUSC provides sunscreen 15-20 minutes before going out in direct sunlight. It is also advisable to reapply sunscreen every 2-3 hours for continuing exposure or after going in the pool or the ocean. The terms “waterproof,” “sweat-proof,” “all-day protection,” and “sunblock” have been deemed misleading and are now disallowed on sunscreen labeling. q Sun safety tip #5 — Makeup and moisturizers with built-in SPF are and a tr uckload of acceptable for most ambient light exposure (walking from the car to work, etc.), but a dedicated sunscreen underneath the makeup or moisturizer is advisable for extended direct sunlight

Health at work

MUSC Urban Farm

q Early Bird Maintenance — 7:30 to 8:30 a.m., Wednesdays q Walking Meditation — 8:45 to 9 a.m., June 3 to June 24 q Saturday Family-friendly Work and Learn —9-11 a.m., Saturday, June 20 For information, contact Johnsusa@ musc.edu or whelan@musc.edu

THE BIG HOT TUB TENT SALE INCREDIBLE SAVINGS

spas to choose from!

Atkinson Pools & Spas June 18th - June 27th

Gated quiet and beautiful condo on James Island Own bedroom and bath. Shared kitchen, living room, and porches. pool, tennis, non-smoker, no pets.

5 miles to downtown, 5 miles to Folly Beach includes wifi, cable, utilities, laundry, part-furnished female renter, available July 1st 1 year lease $600 deposit, $600 per month

call 864-643-7111 or 843-619-0153

the resources to support families across the state to create healthier lifestyles.

Participants can find support via blogs, expert advice, wellness tips and informtion on activities at www.musc. edu/ffc. For information, visit http:// www.myfitfamilychallenge.com. q Chair massages — Free massages are offered to employees midday on Wednesdays. Check broadcast messages for locations and times. q Farmers Markets — Fresh fruits and vegetables are available from local farmers on Fridays from 7 a.m. to 3:30 p.m. at the Horseshoe. Look for returning vendors King of Pops and Angel Blends.

IP07-1325314

Open Mon - Sat 10-5 Sunday 1-5

IP04-1334383

Exposure to ultraviolet light, UVA or UVB, from sunlight accounts for 90 percent of the symptoms of premature skin aging such as wrinkles and skin cancers. It has been estimated that the yearly incidence of skin cancer is greater than that of breast, prostate, lung and colon cancer combined. In addition to skin cancer, deleterious effects of UV exposure include sunburn, photoaging and worsening of some skin conditions.

The sun’s UV rays can damage unprotected skin in only 15 minutes and it only takes a few bad sunburns to raise risk of developing skin cancer later in life.

MUSC’s Department of Dermatology offers the following tips to keep skin protected: q Sun safety tip #1 — Choose a sunscreen marked “Broad Spectrum,” meaning it is designated to block both UVA and UVB rays, in order to best protect against the negative effects of UV exposure. Ultraviolet (UV) light is emitted by the sun and a continuum of wavelengths of UV light strikes the earth’s surface every day. Shorter wavelength UV light is designated “UVB,” and longer wavelength light is designated “UVA.” UVB light is much more likely to cause sunburn, but both UVA and UVB damage can lead to skin cancer and photoaging. q Sun safety tip #2 — Choose a sunscreen with an SPF of 30 or higher.

Sun protection factor (SPF) is the measure of the efficacy of a sunscreen.

Any given sunscreen’s SPF is roughly determined by the ratio of the amount of sunlight required to cause a sunburn in protected (sunscreen applied) vs. unprotected (sunscreen not applied)

1113 Bowman Rd., Mt. Pleasant, SC 843-881-3068 • www.atkinsonpools.com

The CaTalysT, June 19, 2015 11

CLASSIFIED PAGE • Household Personal Items for MUSC employees are free.

All other classifieds are charged at rate below. Ads considered venture-making ads (puppy breeder, coffee business, home for sale, etc.) will be charged as PAID ADS •• PROOF OF ELIGIBILITY REQUIRED * NO MORE THAN 3 LINES * FREE ADS RUN 2 WEEKS ONLY!

PAID ADS are $3 per line ( 1 line = 35 characters) DEADLINE: TUESDAY – 10:00 AM * CLASSIFIED ADS CAN BE E-MAILED TO Chilton@postandcourier.com OR MAILED (134 Columbus St., Charleston SC 29403) Please call Crystal Hilton The Post and Courier (843)718-0812 Office (843)718-0813 Fax Chilton@postandcourier.com *Must provide Badge No. and Department of Employment for employees and Student I.D. Number for MUSC Students.

IP01-1259646

Furniture

Share Rental

New Queen Plush 15 inch Mattress set. Will take $250 Please call 843-270-4283

Share Rental, Medical student preferred, 3br 2ba home in West Ashley, 15 mins to Downtown. $700 month + Utilities.

Call 843-556-0367 or 843-801-3911

King Size Euro Pillow Top Set New, will sacrifice for $275 843-270-4283 Roll top desk – 48”w 22”d & 43”h Medium oak stain, matching chair $125 843-906-3377

3br/2ba Home on large lot in an Old Chas. nbrhd w/dock access. 7 mi. to Dwntn off Maybank hwy. Close Terrace Thtr,groc, shops. Looking to share with med.prof.$1400 month. Utilities Neg. (843)870-2499

Rental Properties Small Carriage House Apt. in I’on, Mt. Pleasant for rent $850 mo.

(Includes Utility’s) (843)881-6033

FulBRighT

sToRm

Continued from Page Seven

supplies, both at home and that they carry with them in their vehicles.”

While employees may bring their children and pets with them in the event of an emergency, Fletcher cautioned that it should be a last resort. “People need to have a child and pet care plan at home,” Fletcher said.

“Bringing children and pets here during a storm is not the best option.”

“While we can certainly keep them safe,” Lehman– Huskamp added, “it doesn’t mean that it’s an enjoyable experience. They’re usually anxious and upset. It’s a foreign environment during a scary storm. It’s not ideal.”

Taylor stressed the need for individual preparedness as well. That begins with staying informed. “I want folks to be prepared, first and foremost, with their family plan,” she said. “That is key. Everyone needs to visit redcross.org/prepare or ready.gov to determine what they need for family planning. Are they going to a shelter or leaving town? They need to be prepared in terms of what they’re taking with them; if they have a pet, they need to have a plan for what they’re going to do with that pet and what the pet will need. They also need to know the evacuation routes; if an evacuation is called, someone might think they’re just going to drive up I–26, but depending on the zone they’re in, they might be led down Highway 61 and into the country somewhere.

Continued from Page Three

“I realized pursuing the Fulbright position could work as a mechanism to collaborate and work with other institutions on their occupational therapy education programs or therapy related issues,” said Coker–Bolt.

“While I’ve done work and established relationships in Ethiopia and Uganda, it is exciting to potentially work in another country, like Haiti or Madagascar, where they are starting their first ever occupational therapy programs.”

Along with her teaching position at MUSC and countless contributions to her immediate community, Coker– Bolt understands that going it alone to produce efficacious treatments is not only infeasible but also unrealistic. She strongly believes to have a meaningful impact on the lives of the marginalized, she must harness the collective expertise of her colleagues.

“I met some colleagues in Ethiopia at Addis Ababa University who are in the process of getting proper approvals to develop a physical therapy curriculum,” said Coker–Bolt. “It made sense that colleagues in Ethiopia and the U.S. work

photo provided

Dr. Patricia Coker-Bolt evaluates an Ethopian child as part of her movement therapy work. together in creating a sustainable training program for students and future health care professionals in East Africa.”

The need for occupational and physical therapists is dire in countries like Ethiopia, where road traffic-related injury risks remain high. The train forward model is what Coker–Bolt plans to implement in combatting injury and disease in low–resource areas. The Fulbright specialist program will buttress

MUSC Notify App: For information on emergency scenarios or to contact Public Safety at the press of a button, download the MUSC Notify App by visiting appstore.musc. edu. photo provided

“It’s also very important that all of our staff, students and faculty members have registered their personal devices with MUSC Alert,” Taylor said. “That’s one of the best ways to stay informed.”

her skills in doing so. Seeing the need for sustainable programs effectively changed the way Coker–Bolt teaches her own students, especially those she mentors on trips abroad.

“We talk a lot about diversity and the underserved in low–income populations.

These medical missions trips show students what it is like to work in a country with very limited resources and people of different cultures, backgrounds and beliefs — you cannot teach that in a lecture,” said Coker–Bolt.

The importance of collaboration and collective thought is more important than ever as global citizens face challenges that require diverse expertise and backgrounds in developing innovative, appropriate solutions.

Coker–Bolt teaches her students that the power is in the collective and change cannot be effected in a vacuum.

“It is great to see the light come on in students’ eyes when they realize that we are very similar to people in other countries, be they partners or patients, and even though we may have different beliefs and cultures we can still work together successfully to solve global health’s most pressing issues,” said Coker–Bolt.

12 The CaTalysT, June 19, 2015

gloBal

Continued from Page Eight

“population that has been considered valuable for locating susceptibility genes of complex disorders.” She knows the issues faced by patients in Costa Rica given the fact that she spent a year there on sabbatical.

By identifying new genes in the host population, new treatments can be developed for patients. Peterseim and her team will conduct clinical examinations and obtain blood samples and DNA from 50 patients in order to describe the phenotype and epidemiology of retinal dystrophy genes in Costa Rica.

Appropriate treatments will be made available to patients who need them.

Daynna Wolff, Ph.D., Director of Clinical Cytogenetics and Molecular Pathology and professor in the Department of Pathology and Laboratory Medicine, will work as co-investigator with Peterseim to identify genetic changes to treat patients with retinal dystrophies in Costa Rica.

Peterseim wrote, “Identification of genetic mutations allows further research into gene replacement, stem cells, and pharmacological intervention, which has been shown to rescue photoreceptors in

animal models and improve vision in human clinical trials.”

“Patient navigation to enhance palliative cancer care services in rural India” The need for palliative care is growing — notably because of the increasing trends in chronic or non–communicable disease around the world. According to the College of Nursing’s Suparna Qanungo, Ph.D., and Kathleen Cartmell’s, Ph.D., project, 80 percent of patients who need palliative care live in low– to middle– resource countries.

What’s worse is that only 10 percent of these patients have access to palliative care services. Patients with cardiovascular disease, cancer, diabetes and HIV need access to care to improve the quality of life not just for themselves, but their families. Qanungo and Cartmell, in concert with their team, seek to fill holes in research and care that only recently have been getting the attention they deserve. Tellingly, the World Health Organization published the first Atlas of Palliative Care just last year.

The lack of evidence-based models for

Kathleen Cartmell, Ph.D. Dual Principal Investigator Assistant Professor College of Nursing palliative care in low income countries has prompted Qanungo and Cartmell’s work to explore the feasibility of utilizing local patient navigators to deliver home– based palliative care services in a low– resource setting in rural Kolkata, India.

The researchers will use a sequential mixed methods approach to conduct key informant interviews with center administrators, clinicians and patients

to develop a palliative care navigation intervention protocol based upon the WHO’s Palliative Care Navigation Toolkit. They will also pilot test the intervention to ensure that it fits with the existing cancer center’s infrastructure and best meets patients’ needs in rural India. “This [project] will enable the patients to receive pain and symptom support in their homes without having to travel long distances to the clinic,” explained Qanungo.

To evaluate the program, researchers will conduct feasibility testing of the palliative care intervention protocol using a single arm trial design. Martina Mueller, Ph.D., associate professor and Barbara Edlund, Ph.D., professor, both in the College of Nursing, are a part of the research team and will work with the principal investigators on the project.

“We found that the biggest need for cancer patients in rural India was palliative care given that patients are diagnosed at later stages and there are so few providers for a huge number of patients,” said Cartmell. “Our goal is to expand the reach of services because only two to three percent of patients have access to palliative care in rural India.”

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