REPORT 2006
Children experience the excitement of discovery every day, and so do our researchers.
is dedicated to finding innovative ways to treat and prevent conditions affecting children’s health.
Because every discovery we make will help children lead happier, healthier lives.
Murdoch Childrens Research Institute conducts world class research to improve the health and wellbeing of children.
Our passionate team of 1000 researchers is dedicated to obtaining knowledge to prevent and treat conditions such as allergies, cancer, cerebral palsy, genetic conditions, obesity, heart disease and premature birth.
Our partnership with the Royal Children’s Hospital and the University of Melbourne’s Department of Paediatrics gives us a unique opportunity to translate our discoveries into real benefits for children. www.mcri.edu.au
The strong record of growth evident in recent years continued in 2006. Total funding for the Murdoch Childrens Research Institute increased from $52million in 2005 to $59.3million in 2006. This was particularly pleasing considering total income was just $15million in 2000, the year of the merger to form the Murdoch Childrens Research Institute. It is clear this has been a very successful and exciting period.
Funding for research related activities increased from $39.7million in 2005 to $45.5million in 2006. Much of this growth came from success in winning competitive grants, in particular from the National Health & Medical Research Council (NHMRC).
MCRI experienced a 450% increase in NHMRC funding over the five years from 2002 to 2006, considerably more than the Australian medical
research sector average. Also, we were awarded $14million from NHMRC for new projects and fellowships commencing in 2007.
Funding growth has allowed MCRI to build larger and more challenging research programs. The results of just a few projects are described later in this report (see page 6).
Two factors, in addition to research grants and contracts, have contributed to income growth in recent years. Both State and Federal Governments have increased infrastructure support for our research activities, which is very pleasing (see page 84).
Community support also appears to be growing, as reflected by increasing donations and fundraising activities. This is backed up by an important contribution from The Royal Children’s Hospital Foundation of more than $3.6million from the Good Friday Appeal.
We continued to work with our partners the Royal Children’s Hospital and the University of Melbourne Department of Paediatrics. Our relationship with these two entities is vital in ensuring this campus continues to be a world leader in paediatric care and research and will be central to a successful effort to create adequate research facilities on the campus.
MCRI is now among the top three largest medical research institutes in Australia, the largest in child health. Staff and students numbers increased from 673 in 2005 to 745 in 2006. While critical mass of researchers has enhanced our ability to conduct world class research, it has also introduced a major problem: how can we find appropriate space to house new staff?
Finding a solution was a major preoccupation for the MCRI board and executive committee in 2006. In the longer term, the answer is to build substantial new space as part of the Royal Children’s Hospital (RCH) redevelopment. There will be substantial cost savings if we are able to do this concurrently, rather than as a separate exercise later.
The Victorian Government has approved, and RCH supported, expansion of our current 12,000 sqm of space to 26,000 sqm in the new hospital, at an estimated total cost of $84million, dependant on the final design and attendant building costs.
MCRI mounted a substantial effort to raise this money with a committed advocacy program aimed at Federal and State Governments as the central component. Success in this endeavour would allow a new building to provide space for approximately double our current staff numbers, but not until 2011 at the earliest.
1 Professor Terry Dwyer and Dame Elisabeth Murdoch
2 Julie Ann Cox, Janet Calvert-Jones, Joan and George Lefroy 3 Peter Tonagh, Foxtel, George Frazis, Nab, Sarah Murdoch and Terry Dwyer
Staff expansion has been projected to continue to 2011, as we wait for the redevelopment to be completed, so this challenge also had to be addressed. Two generous contributions made the achievement of interim space solutions more feasible.
The new 10 storey research building completed in 2006 was funded by a $25million donation from US based Atlantic Philanthropies, with support from our private donors, The RCH Foundation and State and Federal Governments. Every floor but the tenth was fitted out for research.
Secondly, a Federal Government infrastructure grant of $10million allowed MCRI to plan development of laboratories and offices in the tenth floor space, to build greater space efficiency within existing research areas and to lease offsite space to accommodate new research groups.
As these strategic initiatives were introduced, our researchers continued to focus on their mission and made significant contributions to knowledge to improve the health of children.
Our team published 539 research papers in 2006, many in leading journals. These discoveries influenced clinical and public health outcomes directly and some received major international attention, highlighting the importance of the work undertaken at the Murdoch Childrens Research Institute.
Professor Terrie Inder, Dr Peter Anderson (Critical Care & Neurosciences) and their team’s work investigating the development of babies born very prematurely was particularly influential, and was published in the prestigious New England Journal of Medicine.
Using powerful magnetic resonance imaging (MRI), they found that brain abnormalities in these babies seen on MRI scans helped predict developmental problems in the children at age two. This discovery improves our ability to identify children at risk for intellectual and motor development delay so that they can be enrolled in early intervention programs.
Professor Lex Doyle (Critical Care & Neurosciences) and his team reported in the journal Pediatrics that premature babies treated in neonatal intensive care units were less likely to require ventilators if they were treated with a low dose of the steroid dexamethasone. This finding will influence the way very small babies are cared for.
A/Professor Paul Ekert (Early Development & Disease) who was recruited in 2005 to work in the field of cancer research, investigated factors that determine cell death or survival. His team identified that a particular protein (PUMA) was especially important in allowing cells to become malignant. This finding, published in Blood, may be important in future cancer therapies.
A/Professor Colin Robertson (Infection, Immunity & Environment) was part of a worldwide collaboration which looked at international trends in asthma and eczema. His group published in American Journal of Respiratory & Critical Care Medicine research
showing that asthma is on the increase in many countries, but not all. Clues from this research may lead to measures to prevent asthma.
In 2006, we introduced new achievement awards to recognise the exceptional commitment of a number of our research team members. Congratulations to A/Professor Amanda Fosang, A/Professor Melissa Wake, Dr Kerry Fowler, George Teng, Stanley Ho and Dr Jeff Craig (see page 50).
Board of directors & executive committee MCRI once again received invaluable support and guidance from the board and board committees in 2006 (see page 8–9). We are grateful to all for their time and expertise, which is generously provided pro bono. The growth and development of the institute would not be possible without their contribution.
The executive committee undertook a highly successful year of consolidation and progress in 2006, after the restructure in 2005. We farewelled theme director Professor Jonathan Carapetis who left to become Director of the Menzies Research Institute in Darwin. Thank you to Jonathan for his valuable contributions to the executive committee and for his outstanding research output. We were pleased to welcome Professor Julie Bines as the new theme director.
We would like to extend special thanks to our Patron Dame Elisabeth Murdoch AC DBE and our Ambassador Sarah Murdoch for their continued interest and personal support throughout the year.
2006 was a tremendous year of success and development, both in research achievement and organisational operations. We look forward
to continuing to work together with our board, executive and our supporters to ensure future growth and success for the Murdoch Childrens Research Institute.
Mr Laurence G Cox AO Chairman
Professor Terry Dwyer AO MD MPH Director
Directors bring to the board a diverse range of expertise across business and finance, health and research.
1. Chairman
Mr Laurence G Cox AO
Investment banker, director of various public and private companies and community groups
2. Deputy Chairman
Mr WH Hodgson Formerly executive director and director of various private and public companies
3. Mr Martin Armstrong Lawyer and a director of various public and private companies and community groups
4. Mr Anthony Beddison AO Chairman of the Royal Children’s Hospital
5. Professor Glenn Bowes Stevenson Professor of Paediatrics at the University of Melbourne
6. Mrs Janet Calvert-Jones AO Chairman of Herald & Weekly Times Ltd, Chairman of Tapestry Foundation Victoria
7. Mrs Suzi Carp Director of River Capital, member of the MCRI development board and other charitable foundations
8. Mrs Patricia Cross Board director of National Australia Bank and other private and public companies
9. Dr Tony Cull
Chief executive officer of the Royal Children’s Hospital
10. Professor Terry Dwyer AO MD MPH Director of Murdoch Childrens Research Institute
11. Ms Jane Fenton AM Director of Fenton Communications, Chair of The Victorian Health Promotion Foundation
12. Mr Peter Griffin
Investment banker and a director of NM Rothschild & Sons Pty Ltd Group and other public companies and community groups
13. Mrs Judy Paterson Director of Ace Radio Broadcasters
14. Professor Richard Smallwood AO Chief medical officer for the Commonwealth of Australia
15. Professor Geoff Tregear Deputy director of the Howard Florey Institute
Audit, Finance & Risk Management Committee
Monitors the systems and controls established to safeguard the institute’s assets.
Chair, Mr WH Hodgson
Mr Martin Armstrong
Mr Laurence Cox AO
Mr David Craig
Ms Anne Cronin
Professor Terry Dwyer AO
Commercialisation/ IP Committee
Advises the board on business development opportunities for the biotechnology and pharmaceutical industries and on related issues including patent protection.
Chair, Professor Geoff Tregear
Mr Martin Armstrong
Mr Andrew Baker
Ms Anne Cronin
Professor Terry Dwyer AO
Mr Ross McKenzie
Ms Sue Michelmore
Mr Bob Moses
Mr George Raitt
Professor George Werther
Development Board
Provides strategic advice and direction for communications, development and events.
Its purpose is to engage a new generation of supporters.
Chair, Mrs Suzi Carp
Deputy Chair, Mr Angus Reynolds
Mr Ben James
Mr Fraser Macvean
Mr Ion Teska
Dr Narelle Curtis
Mrs Prue Brown
Mr Sam Patterson
Mrs Sarah Murdoch
Mrs Susannah Calvert-Jones
Mr Tony Davies
Outgoing members in 2006
Mr Antony Catalano
Mr Ryan O’Hare
Mr Jason Newman
Ms Alexandra Lowen
Ms Jane Fenton
Mrs Aimee Dean Pritchard
Investment Committee
Advises on the financial investments of the institute
Chair, Mr Peter Griffin
Mrs Suzi Carp
Mr Laurence G Cox AO
Mr David Craig
Ms Patricia Cross
Mr Simon Dighton
Mr Ben James
Mr Dominic Leary
Mr Paul Martin
Mr Ian Miller
Mr John Nickson
Remuneration Committee
Mr Martin Armstrong
Mr Laurence G Cox AO
The executive committee is responsible for the management of research strategy, operational issues, research income and infrastructure development.
ExEcutivE committEE
1. Professor Terry Dwyer Director
2. Ms Anne Cronin chief operating officer
3. Professor Vicki Anderson critical care & Neurosciences
4. Professor John Bateman musculoskeletal Disorders
5. Professor Julie Bines infection, immunity & Environment (from April 2006)
6. A/Professor Jonathan Carapetis infection, immunity & Environment (until April 2006)
7. Professor Andy Choo Laboratory & community Genetics
8. Professor Sheena Reilly Healthy Development
9. A/Professor Andrew Sinclair Early Development & Disease
iNvitED to AttEND
10. Dr Moira Clay Policy Advisor
11. Dr Narelle Curtis PR & Development manager
12. Julia Malone Grants officer
Members
Stakeholders The Board chairman Laurence G cox Ao
Director Professor terry Dwyer Ao mD mPH
Board Committees Audit, Finance & Risk management
commercialisation & iP
PR & Development Dr Narelle curtis Policy Dr moira clay
Clinical Epidemiology & Biostatistics
Australian Paediatric Pharmacology Research Unit
Executive Committee
Early Development & Disease theme Director Professor Andrew Sinclair cancer
Diabetes Embryology
Epigenetics Research
Genetic Hearing Research
Hormone Research molecular Development
Antisense therapeutics Ltd
Infection, Immunity & Environment
theme Directors
Professor Julie Bines
Professor Jonathan carapetis
Allergy & immune Disorders
clinical Paediatrics & therapeutics
Enteric viruses
Environmental & Genetic Epidemiology Research
Gut & Liver
immunisation Research (viRGo / immunisation ccRE)
infectious Diseases & microbiology
international child Health
intestinal Failure & clinical Nutrition
Respiratory Diseases Surgical Research
Musculoskeletal Disorders
theme Director Professor John Bateman
Arthritis & Rheumatology
craniofacial Research
muscular Dystrophy
oral Health Research
orthopaedics & Gait Analysis (Gait ccRE)
Skeletal Biology & Disease
Laboratory & Community Genetics
theme Director
Professor Andy choo
cell & Gene therapy
chromosome & chromatin
Research
clinical Genetics
Research
Genetics
Education & Health
Research
Genetic Health Research
mitochondrial & metabolic Research
cyto-molecular Diagnostics Research
Public Health
Genetics
Ethics
Healthy Development theme Director Professor Sheena Reilly
Alcohol & Drug use
Health Services
Healthy communities
Public Health
Hearing
Language & Literacy
mental Health, Behaviour & Wellbeing
obesity, Physical Activity & Nutrition
Physical Health & Development
Critical Care & Neurosciences
theme Director Professor vicki Anderson
Chief Operating Officer Anne cronin
Academic child Psychiatry
Anaesthesia & Pain management
child Neuropsychology
Developmental Disability Research
Emergency Research
Haematology Research
Heart Research
infant mental Health
medical imaging Research
Neonatal Nursing
Neonatal Research
Neurorehabilitation research
Neuroscience Research
otolaryngology
Paediatric intensive care
Patient Safety Research
Social & mental Health
Aspects of Serious illness
victorian infant Brain Studies
Enabling Facilities & Bioservices
Bioinformatics
Disease models t issue culture
Flow cytometry & imaging Laboratory
Support
Corporate Services
Building Services
Finance
Grants office
Graphic Design
Human Resources information technology
Payroll
occupational Health & Safety
The biggest hearts in the world are often found in the smallest bodies
Helping to save lives and improve the long term health and wellbeing of babies and children with serious conditions requiring surgery and acute care, like heart disease, prematurity, brain injury, epilepsy and autism.
Professor Vicki Anderson vicki.anderson@rch.org.au
Theme overview
This research theme is unique in its capacity to integrate clinical and research activities, taking advantage of the close links between the Murdoch Childrens Research Institute and the Royal Children’s Hospital. Many of our researchers play key roles in patient care, so are in an excellent position to identify cutting edge issues and enable rapid translation of research findings into improved care and management of very sick babies, children and their families.
The establishment of this theme facilitated collaborations leading to important new multidisciplinary research programs, which will advance accurate diagnosis and treatment, identify key factors that may improve child health outcomes and expand our knowledge of the longterm consequences of childhood illness.
We aim to enhance the quality of life for children after surgery and for children with brain injury,
developmental and behavioural disorders. We seek to develop, implement and evaluate intervention programs to enhance patient care and maximise medical, educational and psychosocial outcomes for children.
One of the institute’s objectives in 2006 was to acknowledge and develop clinical research partnerships on the Royal Children’s Hospital campus. This theme brought together a number of new clinical research groups with pre-existing groups, to forge collaborations and provide support to clinician researchers.
The primary goal was to conduct innovative research of an international standard, to improve both medical and psychosocial outcomes for children and to prevent unnecessary secondary problems and complications.
Other priorities included establishing a state of the art functional brain-imaging laboratory, supporting the development of multidisciplinary research collaborations and encouraging
the career development of promising new researchers.
Many of our team already have international reputations in their specific field of expertise. The theme focused on extending the institute’s reputation for excellence in clinical research in child health by facilitating more contemporary multidisciplinary research approaches to illness and recovery.
• Used magnetic resonance imaging (MRI) to investigate brain development in babies born very prematurely, to understand the long term problems associated with premature birth. We found that brain abnormalities seen on MRI scans shortly after birth strongly predict developmental problems at age two, which improves our ability to identify children at risk for intellectual and motor development delay and enrol them in early intervention programs
• Found that sildenafil (Viagra) completely prevents a life-threatening condition called
rebound pulmonary hypertension in babies being weaned from inhaled nitric oxide therapy. This treatment significantly reduced the time these babies spent on a mechanical ventilator and in intensive care
• Researched and implemented a new sedation program in the Royal Children’s Hospital emergency department, resulting in significant improvements sedation protocols
• Researched in and developed a new code grey to respond to confrontational situations involving young people with mental health issues
• Research into mental health issues for young people presenting to the emergency department resulted in new measures including a safe room and an in-house psychiatric professional
• Our Emergency Research group became one of the founding groups for the Paediatric Research in Emergency Departments International Collaborative (PREDICT), a network which aims to provide support for multi-centre trials and research to improve the evidence base for paediatric medicine
• Research dramatically reduced post-operative vomiting in children requiring care by the painmanagement service
• Contributed to growing awareness and understanding of challenges faced by children with traumatic brain injury, especially those with a moderate or severe injury
• Increased understanding and awareness of outcomes for children with cardiomyopathy, leading to better diagnosis and management
The theme’s investment strategy was based on fulfilling the following objectives:
• Increased theme productivity by providing specialist infrastructure to research groups (for example, statistical support, research coordination)
• Encouraged multidisciplinary collaborations both within the theme and across the campus
• Supported new clinical researchers to become externally competitive
• Provided post-doctoral funding to encourage the development of promising young researchers
• Increased infrastructure to the new MRI facility to generate maximum research activity and productivity on the MCRI/RCH campus
• Contributed to the establishment of a new child stroke service
• Encouraged national and international scholars to visit MCRI and develop collaborations with theme researchers
The theme published 184 peer reviewed papers. Highlights were:
• Woodward LJ et al. New England Journal of Medicine 355: 685–694 (2006)
• Piers EF et al. Circulation 114: 2671–2678 (2006)
• Namachivayam P et al. American Journal of Respiratory & Critical Care Medicine 174: 1042–1047 (2006)
• Doyle LW et al. Pediatrics 117: 75–83 (2006)
• Anderson VA et al. Neuropsychology 20: 42–57 (2006)
• Professor Vicki Anderson presented keynote address to the American Psychological Association in New Orleans
• A/Professor Robert Berkowitz was on the editorial board for the Philippines Journal of Otolaryngology
• Frank Muscara received the travel award for the best student abstract submitted at the Australian Association of the Study of Brain Impairment 2006 conference
• Jennifer Re received an National Health & Medical Research Council Public Health (Allied Health Professional) Scholarship
• A/Professor Dinah Reddihough received the Order of Australia
• Leanne Sakzewski was awarded an National Health & Medical Research Council Public Health Public Health (Allied Health Professional) Scholarship
Michael Kean, Michael Ditchfield and Natasha Corbett pictured with the mock MRI
The theme will focus on increasing the productivity of researchers, by investing in additional staff with expertise in research design, analysis and outcomes. Specific research priorities include:
• Establishing a state of the art functional neuroimaging facility
• Investigating the effects of anaesthetic on neurodevelopmental outcomes in infants
• Studying prevalence, characteristics and detection of seizures in critically ill children
• Detecting serum levels following multi-dosing of IV paracetamol in preterm and term babies
• Developing quality of life measure for adolescents with cerebral palsy
• Investigating brain injury in a lamb model of cardiopulmonary bypass
• Looking for age-related structural and functional differences in haemeostatic proteins
• Studying autoimmune neuromuscular disorders
• Investigating neuropsychological, speech and language phenotypes of children with cleft lip and/or palate
• Establishing a mouse cardio vascular physiology laboratory
NHMRC
Project Grants
Peter Anderson
Neonatal Research
$90,975
Vicki Anderson, Cathy Catroppa, Susan Morse, Jeffrey Rosenfeld Child
Neuropsychology
$96,300
Vicki Anderson, Alex Collie, Paul McCrory Child
Neuropsychology
$108,250
Peter Dargaville, John Mills, Colin Morley
Neonatal Research
$60,850
Lex Doyle, Roslyn
Boyd, Terrie Inder, Dinah Reddihough
Neonatal Research
$178,875
Paul Ekert
Neonatal Research
$91,750
Alasdair Vance Academic Child
Psychiatry
$91,750
Fellowships
Peter Anderson
Neonatal Research
Roslyn Boyd Neuroscience Research
Cathy Catroppa Child
Neuropsychology
Paul Ekert
Neonatal Research
Scholarships
Jennifer Re Child
Neuropsychology
Catherine Simpson Heart Research
Alicia Spittle Neonatal Research
David Tingay Neonatal Research
Gehan Roberts Neonatal Research
Leanne Sakzewski Neonatal Research
EXTERNAL GRANTS
Project Grants
Australian & New Zealand College of Anaesthetists
Andrew Davidson
Anaesthesia & Pain Management
$8500
Australian & New Zealand College of Anaesthetists
Andrew Davidson
Anaesthesia & Pain
Management
$8500
Australian Rotary Health Research Fund
Andrew Davis Heart Research
$54,000
Cerebral Palsy Foundation
Lex Doyle, Roslyn Boyd, Peter Anderson, Dinah Reddihough
Neonatal Research
$40,000
Marian & EH Flack Trust
Dinah Reddihough Developmental
Disability Research
$43,742
The Heart Foundation
Lara Shekerdemian
Paediatric Intensive Care
$53,676
The Heart Foundation
Robert Weintraub
Heart Research
$26,284
Jack Brockhoff Foundation
Cathy Catroppa Child
Neuropsychology
$64,220
Jack Brockhoff Foundation
Dinah Reddihough Developmental Disability Research
$17,790
Royal Australasian College of Physicians
Anthea Greenway
Haematology Research
$29,000
Scanlan Foundation
Linda Johnston
Neonatal Research
$21,000
The Telstra Foundation
Roslyn Boyd Neuroscience Research
$40,000
Victor Smorgon Foundation
Franz Babl Emergency Research
$60,000
Victorian Medical Insurance Agency
Dinah Reddihough Developmental
Disability Research
$35,000
Victorian Trauma Foundation
Stuart Lewena Emergency Research
$10,000
Windermere Foundation Limited
Cathy Catroppa Child
Neuropsychology
$11,793
MCRI INTERNAL GRANTS
Part-time Career Grants
Elisabeth Northam Psychological Development
Project Grants
Cathy Catroppa, Jan Matthews, Vicki Anderson, Robyn Stargatt, Susan Morse Child Neuropsychology
Annette da Costa, Andrew Bialocerkowski, John Meara, Ravi Savarirayan, Sheena Reilly, John Clement Child Neuropsychology
Anthea Greenway, Paul Monagle, Vera Ignjatovic Clinical Haematology
Stephen Horton, Joe Smolich Lara Shekerdemian, Paul Monagle, Christian Brizard, Dan Penny Heart Research
Joe Smolich, Vince Russo, Lara Shekerdemian, Dan Penny Heart Research
Alasdair Vance, Mark Bellgrove, Ross Cunningham, Paul Lockhart Academic Child Psychiatry
Postgraduate Health Research Scholarships
Anastasia Pellicano
Neonatal Research
Candice FranichRay Child
Neuropsychology
Megan Spencer Smith Child Neuropsychology
Emma Couper Child Neurosychology
Senem Eren Child Neuropsychology
Anthea Greenway Clinical Haematology
Sharon Kinney Clinical Support Services
Staff list
THEME DIRECTOR
Professor Vicki Anderson
Inge Timmerman
Personal Assistant to Theme Director
Lee-Ann Jones
Personal Assistant to Theme Director
THEME ADVISORY GROUP
Academic Child
Psychiatry
A/Professor
Alasdair Vance
Anaesthesia & Pain Management
Dr Chris Bolton
Dr Andrew Davidson
Child
Neuropsychology
Professor Vicki Anderson
Developmental
Disability Research
A/Professor Dinah Reddihough Emergency Research
Dr Franz Babl
Haematology Research
Professor Paul Monagle Heart Research
Professor Dan Penny
Medical Imaging Research
Dr Tim Cain
Dr Michael Ditchfield
Neonatal Nursing Research
Professor Linda Johnston
Neonatal Research
Professor Colin Morley Neuro Rehabilitation Research
Dr Anna Mandalis
Neuroscience Research
A/Professor Andrew Kornberg
Otolaryngology
A/Professor Robert Berkowitz
Paediatric Intensive Care
Dr Lara Shekerdemian Patient Safety Research
Dr Karen Dunn
Social & Mental Health Aspects of Serious Illness
Dr Brigid Jordan
Victorian Infant Brain Studies
Dr Peter Anderson
Professor Lex
DoyleDr Rod Hunt
THEME MEMBERS
Dr Giulianav Antolovich Research Affiliate
Dr Gordon Baikie Honorary Fellow
Dr Chris Barnes
Research Affiliate
Lisa Bates Research
Psychologist
Merilyn Bear Research Affiliate
Dr Miriam Beaucham
Postdoctoral Fellow
Dr Mark Bellgrove Research Affiliate
Christopher Benjamin Research Assistant
Dr Penny Bolt Research Affiliate
Dr Roslyn Boyd Postdoctoral Fellow
Dr Lesley Bretherton Research Affiliate
Dr Christian Brizard Research Affiliate
Jo Brooks Research Affiliate
James Brown PhD Scholar
Natasha Brown PhD Scholar
Sandra Brown Research Assistant
Dr Fiona Brown Research Affiliate
Nisha Brown Research Affiliate
Kylie Brownfield PhD Scholar
Melissa Casey Research Affiliate
Dr Cathy Catroppa Research
Psychologist
Dr George Chalkiadis Research Affiliate
Edgar Chan Research Affiliate
Dr Michael Cheung Research Affiliate
Bernadette Cirillo Administrative Officer
Dr Beverley Copnell Research Fellow
Emma Couper PhD Scholar
Dianne Crellin
Research Affiliate
Louise Crowe
Research Assistant
Dr Ross
Cunnington Research Affiliate
Dr Annette Da
Costa
Honorary Fellow
Karen Dally
Research Affiliate
Dr Ben Davies
Clinical Research Fellow
Dr Andrew Davis Honorary Fellow
Carmel Delzoppo Research Coordinator
Julian Dooley
Research Assistant
A/Professor Yves d’Udekem
Research Affiliate
Dominic Dwyer
Research Assistant
A/Professor Gary Egan Honorary Fellow
Upeka
Embuldeniya PhD Scholar
Therese English Research Affiliate
Senem Eren
Research Assistant
Cheryl Evans Research Assistant
Dr Rob Eyres
Research Affiliate
Atika Farooqui Research Officer
Carmel Ferretti Research
Psychologist
Candice FranichRay PhD Scholar
Dr Geoff Frawley Research Affiliate
Jane Galvin
Research Affiliate
Alessandra Giannini
Research Assistant
Celia Godfrey Research Officer
Alison Gomes
PhD Scholar
Anne Gordon Research Coordinator
Mardee Greenham Research Assistant
Dr Anthea Greenway Trainee Research Scholar
Dr Joanne Grindlay Research Affiliate
Eve Gu Research Affiliate
Dr Nicole Hall Research Affiliate
Denise Harrison
PhD Scholar
Rosnah Harun Office Manager
Dr Simon Harvey Honorary Fellow
Andrew Hattam PhD Scholar
Sarah Hetrick Research Affiliate
Dr Sandy Hopper Research Affiliate
Kelly Howard PhD Scholar
Dr Rod Hunt
Group Leader
Dr Vera Ignjatovic Senior Research Officer
Mary Iliadis Executive Assistant to Director
Christine Imms
Research Affiliate
Dr Craig Ironfield Research Assistant
Dr Rani Jacobs Honorary Fellow
A/Professor Brigid Jordan Group Leader
Felicity Karsz Research Affiliate
Michael Kean Research Affiliate
Asawari Killedar Research Assistant
Ingrid King Data Manager
Sharon Kinney PhD Scholar
Nicholas Kiraly Technical Assistant
Sarah Knight Research Assistant
Marian Kolta Research Affiliate
Marie Lamb Research Affiliate
Anna Lanigan Research Assistant
Shelly Lavery Research Affiliate
Dr Rick Leventer Honorary Fellow
Dr Stuart Lewena Research Affiliate
Connie Louizos Research Assistant
Greta Ludwig Research Assistant
Belinda Luther Research Physiotherapist
Dr Mark Mackay Research Affiliate
Niloufar Mahdavi Research Assistant
Dr Anna Mandalis Research Affiliate
Dr Catherine Marraffa Research Affiliate
Professor Paul Maruff
Research Affiliate
Rosalie Maxted Research Affiliate
Dr Ian McKenzie
Research Affiliate
Anne Marie McVeigh-Dowd Research Assistant
Dr John Mills
Neonatologist
Carly Molloy PhD Scholar
Professor Paul Monagle Honorary Fellow
Anne Moodie Research
Physiotherapist
Professor Colin Morley Honorary Fellow
Frank Muscara
Research Assistant
Jonathan Mynard Research Assistant
Jennifer Nazareth Research Affiliate
Fiona Newall Research Affiliate
Dr Carol Newnham Research Affiliate
Dr Ed Oakley Research Affiliate
Emra Oguzkaya PhD Scholar
Dr Christine Olesch Honorary Fellow
Jean Ong Research Affiliate
Jane Orton Research Physiotherapist
Dr Greta Palmer
Research Affiliate
A/Professor
Campbell Paul Research Affiliate
Ruth Perkins Clinical Research Fellow
Dr Chidambaram Prakash
Research Affiliate
Tara Quinlivan
Research Assistant
Dr Philip Ragg Research Affiliate
Melinda Randall PhD Scholar
Dr Debbie Rankins Research Officer
Jennifer Re PhD Scholar
A/Professor Dinah Reddihough Honorary Fellow
Sue Reid
Senior Research Assistant
Dr James Rice
Research Affiliate
Dr Anne Rickards Research Psychologist
Emily Roberts Honours Student
Dr Gehan Roberts
PhD Scholar
Dr Marnie Robinson Research Affiliate
Dr Margaret Rowell Research Affiliate
Leanne Sakzewski PhD Scholar
Ingrid Scheffer Honorary Fellow
Hilary Sellars
Research
Physiotherapist
Dr Divyen Shah Research Affiliate
Lisa Sharwood Research Coordinator
Lara Shekerdemian Honorary Fellow
Suzette Sheppard Project Officer
Dr Lloyd Shield Research Affiliate
Mr Tim Silk Research Affiliate
Dr Kate Simpson Trainee Research Scholar
A/Professor Joe Smolich Research Fellow
Megan SpencerSmith
Research Assistant
Alicia Spittle Research Physiotherapist
Michele Spreckley Research Affiliate
Robyn Stargatt Honorary Fellow
Dr Amanda Stock Research Affiliate
Robyn
Summerhayes Research Assistant
Dorothy Tam-Chan Honours Student
Deanne Thompson Research Affiliate
Dr Frances
Thomson Salo Research Affiliate
Dr David Tingay PhD Scholar
Misel Trajanovska PhD Scholar
Nicole Van Der Linden
Research Affiliate
A/Professor Alasdair Vance Honorary Fellow
Janet Walstab
Research Assistant
Dr Hong Wang Research Affiliate
Beverley Weate
Research Assistant
Dr Robert Weintraub Honorary Fellow
Christine Westbury Research Assistant
Jacqueline Williams Research Fellow
Michelle WilsonChing PhD Scholar
Dr Amanda Wood Research Fellow
Damith Woods PhD Scholar
Jacqueline Yamada Research Affiliate
Dr Simon Young Research Affiliate
D E v E lopm E nt & D is E as E
Children experience the excitement of discovery every day, and so do our researchers
Improving understanding and care for children by identifying the role of genes in the developing embryo and in conditions like cancer, diabetes, intersex conditions, deafness and liver diseases.
Professor Andrew Sinclair andrew.sinclair@mcri.edu.au
Theme overview
This theme of research is based on the premise that many childhood diseases have their origins in early development. In this context, development may refer to the change from a non-specialised to a specialised cell or the sort of extraordinary development that occurs in a growing human embryo and foetus during pregnancy.
If there are faults in the genes that regulate these developmental processes, in combination with environmental insults, then normal development may go awry resulting in a variety of childhood diseases.
Our research is focused on understanding childhood conditions such as cancer, diabetes, hearing loss, liver disorders, testis/ovary dysfunction and pituitary disease, leading to improved outcomes for affected children.
In 2006 we built upon existing research priorities so that our research effort maximised the health benefits to affected children. We enhanced synergies and facilitated new collaborations between existing groups and established new collaborations with other themes.
These collaborations brought greater critical mass and expertise to tackle major issues in early development and disease. Successful new collaborations were established between:
• Cancer & Epigenetics: To determine the role of epigenetics in children with leukaemia
• Diabetes & Psychology (Critical Care & Neurosciences): Neuropsychological and neuroimaging analysis of a cohort of diabetic patients
• Embryology & Hormone Research: To analyse the insulin growth factor in early development and disease
• Embryology & Surgical Research (Infection Immunity & Environment): To establish whether testicular descent is regulated in a similar way to limb buds
• Epigenetics & Adolescent Health (Healthy Development): To investigate the role of epigenetics in adolescent drug use and mental health
• Hearing & Healthy Communities (Healthy Development): To study genes contributing to deafness in a cohort of deaf children
• Hormone Research & Healthy Communities (Healthy Development): To examine childhood obesity
• Molecular Development & Bio-informatics: To analyse high-density whole genome arrays in children with gonadal dysgenesis
Investment strategy
Our theme allocated resources to invest in three areas:
1 People: We supported our rising stars Paul Ekert (programmed cell death in cancer), Matt Sabin (childhood obesity) and Jeff Craig and Richard Saffery (epigenetics). We also recruited Stefan White (Leiden University, Netherlands) who has expertise in whole genome array analysis, which has the potential to bring new understanding to a range of childhood diseases
2 Projects: Internal project grant funding for pilot studies or project grant shortfalls
3 Equipment: Strategic investment in core technologies and equipment
Research outcome highlights
• Genetic hearing research group, part of the HEARing Cooperative Research Centre, brought over $30 million in Federal funding to Victoria – of which $500,000 per year will be allocated to MCRI
• Involved in international multi-centre trials researching new treatment regimes for children with medulloblastoma, which resulted in a major improvement in the survival rate for high-risk patients
• Raised awareness about mental health outcomes for children with type 1 diabetes, resulting in mental health management becoming a top care priority for children with this condition
• Together with collaborators, found the autosomal recessive connexin 26 gene that commonly causes deafness in children and established a diagnostic test for this gene, now in use
• Found that better outcomes were achieved through early interventions for intersex conditions at the Royal Children’s Hospital compared to approaches used elsewhere in the world
• Research into the use of bisphosphonates influenced standard treatment for children with osteogenesis imperfecta and for pain control in children with McCune Albright syndrome
The theme published 69 peer reviewed papers. Highlights were:
• Dahl HH et al. Journal of Medical Genetics 43: 850-855 (2006)
• Ekert PG et al. Blood 108: 1461-1468 (2006)
• Lis S et al. Leukemia 20: 1270-1278 (2006)
• Maldonado-Saldivia, J et al. Stem Cells (2006)
• Morley R et al. Journal of Clinical Endocrinology & Metabolism 91: 906-912 (2006)
Awards & achievements
• A/Professor Fergus Cameron was editorial board member for Infusystems Asi
• Dr Jeff Craig was awarded the Murdoch Childrens Research Institute Teamwork award for exceptional commitment to helping the institute achieve its mission, above and beyond his own research activities
• A/Professor Don Newgreen was editor for Development Growth and Differentiation
• A/Professor Don Newgreen was board member of The Epithelial-Mesenchymal Transition International Association
• Tam Nguyen received a Dora Lush Biomedical Scholarship from the National Health & Medical Research Council
• Dr Craig Smith was editorial board member for the Sexual Development journal
• Review and assess performance of all new initiatives related to both staff support and the way groups are structured, to maximise research health outcomes for children
• Improve synergies between laboratory-based, clinical and public health research groups
• Recruit new external groups to focus on specific problems related to childhood disease
• Develop a mentoring system to support grant submissions to improve success rates
• Encourage greater cross-theme collaborations where appropriate
• Develop appropriate strategies to increase critical mass of research groups
• Position groups to be competitive for larger funding opportunities such as National Health & Medical Research programs, Australian Research Council’s Centre’s of Excellence, National Institutes of Health USA and European Union funding opportunities
• Continue support for the molecular medicine seminar program, in conjunction with other themes, to stimulate discussion and disseminate research findings
Grants list
NHMRC
Program Grant
Andrew Sinclair
Molecular Development
$897,332
Project Grants
Fergus Cameron
Diabetes
$137,000
Jeff Craig Epigenetics Research
$91,000
Henrik Dahl Genetic Hearing Research
$133,250
John Heath Cancer
$5592
Paul Thomas Pituitary Development & Disease
$156,500
Fellowships
Jeff Craig Epigenetics Research
Henrik Dahl
Genetic Hearing Research
John Heath Cancer
Richard Saffery
Epigenetics Research
Scholarships
Tam Nguyen EXTERNAL GRANTS
Project Grants
ANZ Medical Trusts
Jeff Craig
Epigenetics Research
$21,000
ANZ Medical Trusts
Heather Gilbertson
Diabetes
$27,128
ANZ Medical Trusts
Christine Hawkins Cancer
$16,000
Association for Research in Otolaryngology
Michelle de Silva Genetic Hearing Research
$500 The Australian Cancer Research Foundation
David M Ashley Cancer
$500,000
Australian Stem Cell Centre
Diana Lepore Pituitary Development and Disease
$1000
Australian Stem Cell Centre
Josef Wagner Pituitary Development and Disease
$2500 Cancer Council
Victoria
Christine Hawkins Cancer
$52,500 The Cass Foundation Limited Ngaire Elwood Cancer
$33,000
The Garnett Passe & Rodney Williams Memorial Foundation
Henrik Dahl
Genetic Hearing Research
$254,136
HopeLab – USA
John Heath
Cancer
$18,702
Juvenile Diabetes Research Foundation
International
George Werther
Hormone Research
$83,807
National Childhood Cancer Foundation (CureSearch)
David M Ashley
Cancer
$16,545
National Childhood Cancer Foundation (CureSearch)
Christine Hawkins Cancer
$61,078
National Childhood Cancer Foundation (CureSearch)
John Heath
Cancer
$26,812
Nutricia Research Foundation
Heather Gilbertson
Diabetes
$10,000
Paediatric Brain Tumor Foundation of the United States
David M Ashley Cancer
$68,523
Perpetual Trustees
Jeff Craig Epigenetics Research
$25,000
Rotary Inner Wheel
Australia Inc
Ngaire Elwood Cancer
$65,000
State Trustees
Australia Foundation
Jeff Craig
Epigenetics Research
$9520
Genetic Hearing Research
Henrik Dahl World Health Organisation
$26,607
Fellowships
Royal Australasian College of Physicians Fellowship
John Heath Cancer
MCRI INTERNAL GRANTS
Part Time Career Grants
George Werther Hormone Research
Project grants
Jeff Craig, Paul Kalitsis, Andy Choo, Ravi
Savarirayan, Michael McKay Epigenetics Research
$48,000
Diana Lepore, Paul Thomas Pituitary Research
$48,000
Andrew Sinclair, Peter McClive, Ruili Li
Molecular Development
$30,000
Staff list
THEME DIRECTOR
Professor Andrew Sinclair
Nicky Woods
Personal Assistant to Theme Director
THEME ADVISORY GROUP
Antisense Therapeutics Ltd
Dr Lynne Atley
Cancer
A/Professor David M Ashley
Diabetes
A/Professor Fergus Cameron
Epigenetics
Dr Jeff Craig
Dr Richard Saffery Embryology
Dr Don Newgreen
Genetic Hearing Research
A/Professor Henrik Dahl
Hormone Research
Professor George Werther
Molecular Development
Andrew Sinclair
THEME MEMBERS
Dr Elizabeth Algar Research Affiliate
Frank
Anastaspoulos Research Affiliate
Elena Andaloro Research Assistant
Melissa Arnold Technical Assistant
A/Professor Leon Bach Research Affiliate
Dr Anurag Bajpai
Senior Clinical Fellow
Andrew Boucher Research Affiliate
Inigo Brinas
Research Assistant
Tom Callahan Research Assistant
Dr Denise Caruso
Senior Research Officer
Linda Chilcott
CBB Clinical Coordinator
Lesley Chow Research Assistant Larissa
Christophidis PhD Scholar
Anna Crack
Research Affiliate
Vinod Dagar
Research Assistant
Hinda Daggag
PhD Scholar
Michelle de Silva
Research Officer
Dr Tam Dieu
PhD Scholar
Laura Downey
Occupational Trainee
Karen Egan
Research Affiliate
Professor Henry Ekert
Clinical Research
Affiliate
A/Professor Paul Ekert
Group Leader
Dr Ngaire Elwood
Cord Blood Bank (CBB) Manager
Melissa Ferguson
Research Assistant
Jenny Forrester
CBB Clinical Coordinator
Samantha FrancisPester
Research Assistant
Sarah Fraser
Research Assistant
Libing Fu
Visiting Academic
Jenny Fuller
Research Assistant
Rebecca Gebert
Research Affiliate
Christiane Giel
Visiting Student
Dr Heather Gilbertson
Research Affiliate
Sonja Gustin
Research Officer
Kellie Hardy
Research Assistant
Christine Hawkins
Group Leader
Sarah Healy
Research Assistant
Dr John Heath
Senior Research Fellow
Jacki Heraud
Research Assistant
Sandra Higgins
Research Assistant
Jennifer Houlihan
Research Affiliate
Quanah Hudson
PhD student
Dr Honor Hugo
Postdoctoral Fellow
Rebecca Humphreys
Research Affiliate
Wendy Hutchison
Scientific Officer
Dr Anissa Jabbour
Research Officer
Lee-Ann Jones
Administrative Assistant
Eric Joo
PhD Scholar
Sue Kantor
Research Affiliate
Jane Kaye
CBB Clinical Coordinator
Maria Kokkinos
Visiting
Postdoctoral Fellow
DrIldi Koves
Research Affiliate
Lisa Kropf
CBB Clinical Coordinator
Dr Diana Lepore
Postdoctoral Fellow
Shan Li
Research Assistant
Dr Ruili Li
Senior Research
Officer
Elizabeth Loughlin
Research Affiliate
Dr Shehnaaz Manji
Research Fellow
Denise Miles
PhD Scholar
Dr Ruth Morley
Honorary Fellow
Sally Morrissy
CBB Clinical
Coordinator
Andrea Muscat
Research Assistant
Li Yong Ng
Research Affiliate
Tam Nguyen
PhD Scholar
A/Professor
Elisabeth Northam
Research Affiliate
Dr Amanda Notini
Postdoctoral Fellow
Dr Michele O’Connell
Clinical Research Fellow
Dr Thomas Ohnesorg
Postdoctoral Fellow
Marisel Peverelli
PhD Scholar
Susan Pongrac
CBB Scientist
Sylvia Pung
Honours Student
Maysa Qazag
PhD Scholar
Dr Supriya Raj Research Affiliate
Anne Reilly Research Affiliate
Chris Riffkin
Research Assistant
Jeanette Ripper
CBB Production Manager
Kelly Roeszler
Research Assistant
Jacqui Rosen
Research Affiliate
Dr Vincenzo Russo
Senior Scientist
Dr Matthew Sabin
Clinical Research Fellow
Emma Schouteten
Technical Assistant
Margaret Shaw
PhD Scholar
Dr John Silke
Honorary Fellow
Dr Peter Simm
Clinical Research Fellow
Dr Matthew Simpson
Postdoctoral Fellow
Dr Craig Smith
Honorary Fellow
Dr Julieta Solis
Clinical Research Fellow
Candice Taylor
Research Assistant
Kally Theodore
Research Assistant
Dr Annette Trickett
Research Affiliate
Jocelyn van den Bergen
Research Assistant
Josef Wagner
PhD student
A/Professor Garry Warne
Honorary Fellow
Blaise Weinrich
Research Assistant
Dr Patrick Western
Postdoctoral Fellow
Marguerite
Wijetunge
Research Affiliate
Fee Yee Wong
Research Affliliate
Nicholas Wong
Postdoctoral Fellow
Dr Margaret Zacharin
Research Affiliate
Faten Zaibak
Visiting Researcher
Dr Sally Zeunert
Research Affiliate
Dong Zhang
Research Assistant
A happy and healthy start for a happier, healthier future
Giving children and young people the best start in life by preventing poor health, enhancing wellbeing and investigating common problems like obesity, nutrition, depression, substance abuse, behavioural conditions and language and literacy.
Professor Sheena Reilly sheena.reilly@mcri.edu.au
Theme overview
Our research examines the physical, social and environmental factors that shape the health of children and young people. We aim to improve their quality of life by informing public policy, service systems and professional practice in clinical and community settings, including family-focused programs. Our theme encompasses the majority of public health research undertaken on the campus and comprises the Centre for Adolescent Health and the Centre for Community Child Health, together with other research groups using similar methodologies and approaches.
Our research group’s priorities were focussed on common health problems affecting children, young people and their families. We addressed mental health, nutrition, development and behaviour, adaptation to chronic illness, language, literacy and hearing in children, by focusing on the preventable social factors and early precursors.
The Centre for Adolescent Health continued its excellent work aimed at making a difference to the lives of young people by advancing knowledge about adolescent health, practice and policy. One of the centre’s research projects, 2000 Stories, continued to provide one of the most comprehensive pictures of adolescent development available worldwide and was internationally acclaimed for the outstanding knowledge it contributed to improving the health and wellbeing of young people.
The Centre for Community Child Health continued its outstanding research, learning more about the health of Australia’s children. The Centre focused on health promotion, prevention, screening and early detection. It worked to solve common problems earlier through its growing program of primary care trials in the community.
Our strategy aimed to strengthen and grow our research groups:
• Seed funding for critical pilot studies: Provided the initial funding needed to increase future success of securing competitive grant applications. For example, the Language & Literacy research group was awarded pilot funding to collect preliminary data on the prevention of early language delay in the primary care setting, which led to funding from the National Health & Medical Research Council to conduct a cluster randomised trial
• Cross-theme initiatives: Combined the work of our Alcohol & Drug Use research group with the Epigenetics research group from the Early Development & Disease theme, to examine the role of epigenetics in adolescent drug use and mental health
• Whole-theme initiatives: Funded projects that benefited the entire theme, such as the development of the Victorian Paediatric Research Network and a Network of Mature Australasian Longitudinal Studies
• Provided funding for vital equipment
Research outcome highlights
• The Centre for Community Child Health was involved in developing the landmark Australian website www.raisingchildren.net.au, which provides expert information on raising children from newborns to eight years of age
• The Victorian Adolescent Health Cohort was recognised as one of the ‘10 of the best’ National Health & Medical Research Council funded health and medical research successes
• The Gatehouse Project approach was shown to result in significant sustained decreases in smoking, substance use and externalising behaviours in school-age children, leading to wide adoption of the program both in Australia and overseas
• Research into cannabis use showed that it is linked to a range of problems in young people, including problems associated with mental health, other substance use, social development and education. This research helped inform Australian policy and was included in a major public health campaign in the USA
• Research into the effect of alcohol on young people led to advocacy for a unique approach that involves the reduction of alcohol use, as well as harm minimisation. Our research suggested that delaying the age of alcohol use will result in less binge drinking, lower hospitalisations for alcohol-related problems and reduction of alcohol use in young people
• Demonstrated that maternal child health nurses can be trained to effectively treat infant sleep problems, resulting in lower prevalence of depression in mothers
• Secured the coordinating role for the Victorian universal newborn hearing screening program. The program will soon extend to all 65,000 babies born in Victoria each year
• Our 15 years of population hearing research influenced the adoption of hearing screening programs across Australia, with a universally available newborn screen now standard care
• The Australian Early Development Index (AEDI): building better communities for children project was conducted by the Centre for Community Child Health in partnership with the Telethon Institute for Child Health Research, Perth. Between 2004 and 2007 AEDI has been implemented in 54 communities (870 schools, 1868 teachers, 31,929 children) from seven states and territories
• The Centre for Community Child Health developed a series of policy briefs outlining evidence and policy recommendation for areas of early childhood. Funded by BHP Billiton, these were strategically disseminated and extensively used and quoted by governments around Australia
Publications
The theme published 54 peer reviewed papers. Highlights were:
• Duncan RE et al. British Medical Journal 333: 1066–1068 (2006)
• Moran P et al. British Journal of Psychiatry 188: 374–379 (2006)
• McCallum Z et al. International Journal of Obesity (2006)
• Wake M et al. Pediatrics 118: 1842–1851 (2006)
• Hiscock H et al. Pediatrics 119: 86–93 (2006)
Awards & achievements
• Dr Angela Morgan received a National Health & Medical Research Council Australian Clinical Research Fellowship
• Professor Frank Oberklaid was editor-in-chief for the Journal of Paediatrics and Child Health
• Professor George Patton was on the editorial board for the Journal of Adolescent Health
• A/Professor Ann Sanson was consulting editor for the International Journal of Psychology
• Professor Sheena Reilly was an editorial board member for the International Journal of Language and Communication Disorders
• Kerry Ttofari Eecen was awarded National Health & Medical Research Council Public Health (Allied Health Professional) Scholarship
• A/Professor Melissa Wake was awarded the Murdoch Childrens Research Institute Rising Star Award, For excellence in research, for researchers less than 10 years postdoctoral
• Professor George Patton was a member of the WHO Technical Steering Committee for Child & Adolescent Health
• Dr Rony Duncan was awarded the Young Tall Poppy Award for Science, awarded by the Australian Institute of Policy & Science
Our investment strategy for 2007 is to build capacity in the theme. There are two main initiatives. The first is to attact outstanding new researchers from other organisations, to enhance and grow the focus of our research intrestes and to create new research strengths.
The second is to continue to invest in our talented and dedicated staff and to provide the necessary structure to enhance the theme’s research activities.
We will provide support for the postdoctoral fellows employed through the capacity building grant awarded by the National Health & Medical Research Council and we will endeavour to support specific expertise that will give us the competitive edge.
Grants list
NHMRC
Project Grants
George Patton, John Carlin, Carolyn Coffey
Adolescent Health
$200,250
Sheena Reilly, Edith Bavin, Margot Prior, Melissa Wake, Joanne Williams
Language & Literacy
$157,875
Melissa Wake, George Patton, Elizabeth Waters, Joanne Williams, Kylie Hesketh
Community Child Health
$206, 925
Melissa Wake, Michael Bittman, Michael Sawyer, John Carlin
Community Child Health
$43,300
Melissa Wake, Jane Gunn, LouiseBaur, Zoe McCallum, Kay Gibbons
Community Child Health
$214,200
Joanne Williams, John Toumbourou
Community Child Health
$176,350
Joanne Williams, Melissa Wake
Community Child Health
$60,550
Fellowships
Angela Morgan Language & Literacy
Melissa Wake
Community Child Health
Scholarships
Michelle Campbell Community Child Health
Julie Green
Community Child Health
Jenny Hynson
Physical Health & Development
Andrew Lovett
Adolescent Health
Kerry Ttofari
Languae & Literacy
Travel Grants
Julie Green Community Child Health
$8634
EXTERNAL GRANTS
Program grant
Victorian Helath Promotion Foundation
George Patton
Adolescent Health
$100,000
Project Grants
Alcohol Education & Rehabilitation Ltd
George Patton
Adolescent Heath
$46,670
Anna Jane Trust
Harriet Hiscock
Community Child Health
$9000
Asthma Foundation, Victoria
Susan Sawyer Adolescent Health
$29,807
Australian Research Alliance for Children & Youth
Sharon Goldfeld
Community Child Health
$27,374
Australian Rotary Health Research Fund
George Patton, Craig Olsson Adolescent Health
$60,000
BHP Billiton
Frank Oberklaid
Community Child Health
$90,000
Bokhara Foundation Ltd
Sheena Reilly Language & Literacy
$15,000
Colonial Foundation
Craig Olsson, George Patton
Adolescent Health
$150,000
Cystic Fibrosis
Australia
Susan Sawyer
Adolescent Health
$11,873
Department of Human Services
John Toumbourou
Adolescent Health
$50,000
Department of Human Services
Melissa Wake
Community Child Health
$120,000
Department of Family & Community Services
Frank Oberklaid
Community Child Health
$100,000
Diabetes Australia Research Trust
Kay Gibbons
Community Child Health
$45,455
Eli Lilly Australia
Melissa Wake
Community Child Health
$20,000
Helen Macpherson
Smith Trust
Frank Oberklaid
Community Child Health
$10,000
RE Ross Trust
June McLoughlin, Frank Oberklaid
Community Child
Health
$100,000
Telstra Foundation
Sophie Reid
Adolescent Health
$50,000
Telstra Foundation
Harriet Hiscock
Community Child Health
$30,000
Victorian Health Promotion Foundation
George Patton
Adolescent Health
$61,100
Victorian Health Promotion
Foundation
George Patton, John Toumbourou
Adolescent Health
$92,500
Fellowships
Victorian Health Promotion
Foundation
Craig Olsson
Adolescent Health
Travel grant
Ian Potter Foundation
Zeffie Poulakis
$2000
MCRI INTERNAL GRANTS
Part Time Career Grants
Harriet Hiscock
Healthy
Communities
Project grants
Jordana
Bayer, Harriet Hiscock, Melissa Wake, Obioha
Ukuomunne
$40,000
Healthy Communities
Postgraduate health research scholarships
Deidre Gartland
Mental Health, Behaviour & Wellbeing
Elizabeth Smith
Language & Literacy
Staff list
THEME DIRECTOR
Professor Sheena Reilly
Kylie Gilmartin
Personal Assistant to Theme Director
THEME ADVISORY GROUP
Alcohol & Drug Use
A/Professor John Toumbourou
Health Services
Professor Frank Oberklaid
Healthy
Communities
Dr Sharon Goldfeld
Language & Literacy
Professor Sheena Reilly
Mental Health, Behaviour & Wellbeing
Dr Lyndal Bond
Professor George Patton
Obesity, Physical Activity & Nutrition
Dr Kay Gibbons
Physical Health & Development
Professor Susan Sawyer
Public Health
Hearing
A/Professor
Melissa Wake
THEME MEMBERS
Donna Anderson
Project Officer
Kate Anderson Telephone Interviewer
John Bamberg Project Manager
Dr Melinda Barker Research Officer
Dr Rachel Barratt Research Officer
Yin Barrett Research Assistant
Amy Basile Research Assistant
Dr Jordana Bayer Research Affiliate
Kristina Bennett Research Manager
Anna Benton Research Assistant
Frances Biffin
Research Assistant
Melanie Bissett Research Affiliate
Catherine Bolzonello Research Assistant
Angela Bourne Research Assistant
Helen Butler
Project Coordinator
Petrea Cahir
Administrative Assistant
Dr Michele Campbell PhD Scholar
Louise Canterford Research Assistant
Professor John Carlin
Clinical Epidemiology & Biostatistics Unit
Eileen Cini
Research Assistant
Melissa Coutts
Senior Project Officer
Diana Crocker Administrative Assistant
Judy Davey Research Affiliate
Natalie De Bono Project Coordinator
Dr Sarah Drew Research Affiliate
Amanda D’Souza Project Officer
Dr Rony Duncan Research Officer
Dr Patricia Eadie Research Fellow
Dr Daryl Efron
Research Affiliate
Dr Tracy EvansWhipp Research Officer
Dr Estelle Farrar Project Officer
Fides Ferlin Research Affiliate
Nola Firth
Research Officer
Coordinator
Maria Fong Project Officer
Lucianne Foy
Research Affiliate
Dr Alexandra Fraser Project Officer
Rosanne Freak-Poli Research Assistant
Philippa Garrard Group Member
Deirdre Gartland
Research Assistant
Bianca Gazzola
Team Leader
– Dietetics Research
Bibi Gerner
Research Assistant
Julie Green
Research Fellow
Philip Greenwood
Research Assistant
Dr Bill Hallam PhD Scholar
John Hargreaves Research Officer
Angela Hassett PhD Scholar
Dr Sheryl Hemphill
Project Manager
Dr Harriet Hiscock
Senior Postdoctoral Fellow
Rebekah Hobson
Technical Assistant
Emily Horwill
Research Assistant
Tessa Hughes Senior Project Officer
Dr Jenny Hynson
Research Affiliate
Hasherah Ibrahim PhD Scholar
Hannah Jeans
Research Assistant
Stephanie Jones PhD Scholar
Richard Kaa
Research Affiliate
Sylvia Kauer
Research Assistant
Jenelle King
Research Assistant
Aneta Kotevski
Visiting Student
Andrea Krelle
Project Manager
Christina Laidlaw Project Officer
Penny Levickis Research Assistant
Dr Andy Lovett PhD Scholar
Hui Min Low Research Assistant
Megan Mathers
Research Assistant
Dr Zoe McCallum Senior Research Officer
Rachel McConaghy
Communication & Translation
Maria McKenzie PhD Scholar
June McLoughlin Research Affiliate
Amanda Maguire Research Affiliate
Dr Tim Moore Senior Research Fellow
Dr Angela Morgan Research Fellow
Kate Naish
Project Officer
Natasha Napiza Visiting Researcher
Shannon Newman Senior Project Officer
Cattram Nguyen Research Assistant
Ruth Nicholls PhD Scholar
Mary Nitto
Administrative Officer
Dr Craig Olsson Postdoctoral Fellow
Jessica Palmer
Research Assistant
Mandy ParkinsonBates Research Assistant
Dr Zeffie Poulakis Research Officer
Elke Power Research Assistant
Anna Price Research Assistant
Dr Jenny Proimos Medical Scientist
Laura Punaro Research Assistant
Dr Sophie Reid Research Officer
Trudie Renowden Project Officer
Candice Roberts Project Officer
Lucy Rogers Research Assistant
Dr Katherine Rowe Honorary Fellow Charmaine
Sambathkumar Research Affiliate
A/Professor
Ann Sanson Research Affiliate
Mary Sayers Senior Project Officer
Melinda Schambre Research Affiliate
Emma Sciberras Research Assistant
Dr Jillian Sewell Honorary Fellow
Jane Sheehan Research Assistant
Jessie Shinn Research Assistant
Helen Shoemark Research Affiliate
Libby Smith PhD Scholar
Rachel Smith Research Assistant
Tracey Spilsbury
Research Assistant
Daniel Strachan Project Officer
Sherryn Tobin
Research Assistant
Michelle Tollit
Research Assistant
Lea Trafford Project Officer
Kerry Ttofari Eecen
PhD Scholar
Dr Friederike Veit Honorary Fellow
Carly Veness Research Assistant
Amy Watts
Research Assistant
Debra Williams Administrative Assistant
Dr Joanne Williams Senior Research Fellow
Ian Williams
Research Officer
Aisha Williams
Administrative Assistant
Jessica Wyatt
Research Assistant
Dr Michele Yeo Research Fellow
Our research addresses common infections, immune conditions, allergies and immunisation and also aims to solve severe health problems that affect many children living in settings of poverty.
Professor Julie Bines (from April 2006) julie.bines@rch.org.au
Professor Jonathan Carapetis (until April 2006)
Theme overview
We have a strong emphasis on translating our research findings into practical interventions to reduce death and disease and prevent conditions such as asthma, allergies, gastrointestinal diseases and infectious diseases.
Vaccine development is a large part of our research, to enable us to prevent rather than just treat disease. Much of our research aims to improve the lives of children throughout Australia and in developing countries, especially in the Asia Pacific region.
Our research explores the interaction of people (particularly the immune system and the gut) with the outside world — infectious agents and allergens. Immunisation and allergies figure prominently in the work of our researchers.
We have some of the best laboratory scientists and public health researchers in Australia and the prominence of clinicians in our theme allows us to maintain direct contact with the primary beneficiaries of our research: our young people.
Research priorities
• New strategies for the prevention of eczema
• Development of the RV3 rotavirus vaccine
• Improving the diagnosis of childhood tuberculosis
• Understanding how the gut recovers after major bowel surgery
• Exploring new therapies for the treatment of constipation and investigating causes of Crohn’s disease
• Reducing ear disease in indigenous children in the Northern Territory
Investment strategy
Our funds were used to support research with the greatest potential to improve child health or health-related practices, particularly in settings of poverty. Some of these were expansions of existing programs, (rotavirus vaccine and food allergy research) and others were new (environmental and genetic epidemiology research).
We were focussed on supporting emerging research leaders of the future and funding the occasional high risk area that, if successful, could produce major findings with important health benefits.
Research outcome highlights
• A study investigating group A streptococcus bacteria was hailed one of the ‘10 of the best 2006’ National Health & Medical Research Council funded health and medical research successes
• Developed a clinical case definition for intussusception, which was used in clinical trials that established the safety of two new rotavirus vaccines
• Investigated tests for tuberculosis diagnosis, establishing that newer blood tests may be inaccurate in children and that skin tests must continue to be used to diagnose tuberculosis in children
• Involved in crucial clinical trials for the new cervical cancer vaccine, Gardasil, which was necessary for the licensing of the vaccine. It is now available for use in Australia and around the world
• Identified slow-transit constipation caused by neuronal intestinal dysplasia as a new childhood disease, with one to two children diagnosed each month at the Royal Children’s Hospital
• Conducted research as part of a World Health Organization and UNICEF program, to understand
the deficiencies of quality of care for children in hospitals in developing countries, leading to the implementation of strategies to improve care through measures such as clinical guidelines and training of staff
Publications
The theme published 126 peer reviewed papers. Highlights were:
• Bines JE et al. Bulletin of the World Health Organization 7: 569–575 (2006)
• Boyle RJ et al. American Journal of Clinical Nutrition 83: 1256–1264 (2006)
• Duke T et al. Lancet 9514: 925 (2006)
• Lim YW et al. Nature 444: 9–18 (2006)
• Robertson CF et al. American Journal of Respiratory & Critical Care Medicine (2006)
Awards & achievements
• Dr Peter Vuillermin was awarded a National Health & Medical Research Council Medical Scholarship
• Dr Annette Webb was awarded a National Health & Medical Research Council Medical Scholarship
2007
• To further develop an affordable rotavirus vaccine to prevent gastroenteritis for the global community
• To commence and continue vaccine trials for pandemic influenza, rheumatic fever and group A streptococcal diseases, pneumococcal infections in developing countries, maternal pneumococcal infections in the Northern Territory among indigenous women, herpes simplex viruses and bacterial meningitis
• To continue studying the best way to protect high risk children against vaccine preventable disease including cancer survivors, asplenic children and those receiving immunosuppressive therapies
• To start a clinical trial to determine the effect of vaccine strain on the immune response to BCG immunisation in infants
• To continue trials of new immunosassays for the diagnosis of tuberculosis in children
• To develop molecular methods to improve the diagnosis of children with fever
• To establish an international consortium that aims to pool existing child cohort data to examine the causes of rare diseases such as leukaemia
• To build on our past work on the early life environmental determinants of asthma and multiple sclerosis
• To determine the cause of Crohn’s disease and identify the factors that affect its severity
• To form Australia’s first small bowel transplant unit and intestinal failure centre of excellence
• To further define the outcome of childhood asthma in adult life and explore the relationship between childhood asthma and chronic obstructive pulmonary disease
• To develop sensitive and reproducible measures of early disease severity in young children with cystic fibrosis, to evaluate strategies to minimise progression of the disease
• To translate findings about chronic constipation into therapeutic interventions
• To investigate new therapies for the treatment of allergies
• To improve understanding of the causes of peanut allergy
• To determine the role of probiotics in preventing allergy in children
Grants list
NHMRC
Centre for Clinical Research Excellence
Terry Nolan, Jonathan Carapetis, Jim Buttery, Susan Sawyer, Frank Oberklaid Immunisation Research
$400,000
Project Grants
John Hutson
Surgical Research
$113,250
Colin Robertson, Mike South, Peter Hewson, Peter Vuillerman
Respiratory Diseases
$139,250
Bridget Southwell, John Hutson, Anthony Catto-Smith, Val Robertson Surgical Research Group
$124,800
Fellowships
Katie Allen
Allergy & Immune Disorders
Julie Bines
Intestinal Failure & Clinical Nutrition
Jonathan Carapetis
International Child Health
Carl Kirkwood
Enteric Viruses
Kumar Visvanathan Infectious Diseases & Microbiology
Scholarships
Sarah Moberley
International Child Health
Peter Vuillerman
Respiratory Diseases
Annette Webb Gut & Liver
EXTERNAL GRANTS
Project grants
Australian College of Dermatologists
Jonathan Carapetis
International Child Health
$43,000
BHP Billiton
Julie Bines
Intestinal Failure & Clinical Nutrition
$100,000
Burge Trust
Sarath
Ranganathan
Respiratory Diseases
$44,420
Cystic Fibrosis
Australia
Phil Robinson
Respiratory Diseases
$19,279
Department of Health & Aged Care
Graeme Barnes
Enteric Viruses
$40,000
Geoffrey Gardiner Dairy Foundation
Ltd
Carl Kirkwood
Enteric Viruses
$10,500
GlaxoSmithKline
Graeme Barnes
Enteric Viruses
$30,000
GlaxoSmithKline
Julie Bines
Intestinal Failure & Clinical Nutrition
$20,000
Oara President
Sarath Ranganathan
Respiratory Diseases
$4727
The RE Ross Trust
Jonathan Carapetis
International Child Health
$44,850
Rotavirus Vaccine
Program PATH
Carl Kirkwood
Enteric Viruses
$10,500
University of California, San Francisco
Phil Robinson
Respiratory Diseases
$83,401
World Health
Organization
Graeme Barnes
Enteric Viruses
$53,525
World Health
Organization
Carl Kirkwood
Enteric Viruses
$26,288
World Heart Federation
Jonathan Carapetis
International Child Health
$70,490
Fellowships
Royal Australasian College of Physicians
Fellowship
Katie Allen
Allergy & Immune Disorders
Scholarships
Swiss National Science Foundation
Nicole Ritz
Infectious Diseases & Microbiology
$32,998
MCRI INTERNAL GRANTS
Part-time Career Grants
Graeme Barnes Enteric Viruses
John Hutson
Surgical Research
Mimi Tang
Allergy & Immune Disorders
Project Grants
Graeme Barnes, Julie Bines, Jim Buttery, Carl Kirkwood, Ruth Bishop
Enteric Viruses
$55,000
Julie Bines, Bridget Southwell, Joel Bornstein, Russell Taylor, Peter Fuller
Intestinal Failure & Clinical Nutrition
$43,000
Julian Kelly, Mike South, Trevor Duke, John Carlin
International Child Health
$48,000
Anne-Louise Ponsonby, Tony Catto-Smith, Jane Halliday, Ruth Morley, John Carlin, Don Cameron, Terry Dwyer
Environmental & Genetic Epidemiology Research
$63,000
Staff List
THEME DIRECTOR
Professor Julie Bines (from April 2006)
Professor Jonathan Carapetis (until April 2006)
Paula O’Malley
Personal Assistant to Theme Director
THEME ADVISORY GROUP
Allergy & Immune
Disorders
Dr Ralf Heine
A/Professor
Mimi Tang
Clinical Paediatrics & Therapeutics
A/Professor
Noel Cranswick
Professor
Mike South
Enteric Viruses
Dr Carl Kirkwood
Environmental & Genetic Epidemiology
Research
Professor AnneLouise Ponsonby
Gut & Liver
A/Professor
Tony Catto-Smith
Immunisation
Professor
Terry Nolan
Infectious Diseases & Microbiology
A/Professor
Nigel Curtis
Professor Roy Robins-Browne
International Child Health
Professor Jonathan Carapetis (until April 2006)
A/Professor
Trevor Duke (from April 2006)
Intestinal Failure & Clinical Nutrition
Professor Julie Bines
Respiratory Diseases
Dr Sarath
Ranganathan
Professor
Colin Robertson
Surgical Research
Dr Bridget Southwell
THEME MEMBERS
Dr George Alex Research Affiliate
Dr Karyn Alexander Senior Research Fellow
Dr Katie Allen Group Leader
Yasir Alshareef Research Affiliate
Susan Anderson Research Assistant
A/Professor Ross
Andrews
Research Affiliate
Seong Jin Ang AMS Scholar
Amy Augé
Administrative Officer
Christine Axelrad Research Assistant
Kristy Azzopardi Research Assistant
Leonie Baker Research Assistant
Dr Debbie Baldi Research Officer
Anne Balloch Research Officer
Professor Graeme Barnes Group Leader
Dr Aleya Begum Study Doctor
Dr Vicki BennettWood Research Affiliate
Andrea Bigham Research Assistant
Professor Ruth Bishop Group Leader
Nada BogdanovicSakran Research Assistant
Michelle Boglis Research Assistant
Karen Boniface
Research Assistant
Dr Bob Boyle
Research Fellow
Janet Briggs
Research Assistant
Clare Brophy Research Assistant
Dr Penelope Bryant
PhD Scholar
Dr Nicole Buck Postdoctoral Fellow
Dr Mirjam Bueno do Mesquita Research Affiliate
Maria Bufalino Research Affiliate
Dr Jim Buttery
Senior Research Officer
A/Professor Don Cameron Research Affiliate
David Cannan
Research Assistant
Kylie Carville
Research
Coordinator
Rosemary Carzino Research Assistant
Rebecca Cerbu
Administrative Assistant
Janet Chase Research Officer
Daphne Cheah Research Officer
Bin (Amy) Chen Research Assistant
Catherine Cheng Honours Student
Dr Ada Cheung Study Doctor
Elizabeth Christie
Administrative Assistant
Hsu En Chung Research Affiliate
Melanie Clarke
Research Assistant
Danielle Clucas AMS scholar
Samantha Colquhoun Research Coordinator
Robert Commons
Research Affiliate
Dr Tom Connell PhD Scholar
Dr Nigel Crawford
Clinical Research Fellow
Lyn Crellin
Research Affiliate
Dr Gabriel Dabscheck Study Doctor
Dr Andrew Daley
Research Affiliate
Dr Margaret Danchin
PhD Scholar
Siobhan Davenport
Administrative Assistant
Dr Jennifer Davey Study Doctor
Nicole Davidson
Research Assistant
Dr David Delaney Research Affiliate
Nicole Donker PhD Scholar
Sandy Dupuis Research Assistant
Dr Wei Lyn Fah Study Doctor
Paige Fahey Honours Student
Pam Farmer
Research Assistant
Peta Fennessy Research Assistant
Kate Ferguson Clinical Research Fellow
Professor Suzanne Garland Honorary Fellow
Deborah Gercovich Research Assistant
Susie Germano Research Affiliate
Jane Gibson Research Assistant
Judith Glazner PhD Scholar
Vivienne Gorman Administrative Officer
Rebecca Gorrell PhD Scholar
Dr Gaudi Hafen Research Affiliate
A/Professor Winita Hardikar Honorary Fellow
Efrant Junior Harnaen Research Affiliate
Andrea Harrington PhD Scholar
Dr Jo Harrison Research Affiliate
Emily Hart Research Affiliate
Dawn Harwood Research Affiliate
Margaret Heffernan PhD Scholar
Dr Mary Herzig Research Affiliate
Dr David Hill Research Affiliate
Erin Hill Research Assistant
Dianna Hocking Research Affiliate
Dr Geoff Hogg Honorary Fellow
Alice Holloway Research Assistant
Dr Lana Horng Study Doctor
Professor John Hutson Honorary Fellow
Fran Justice Research Assistant
Johanna Kappers Research Affiliate
Marita Kefford Study Co-ordinator
Dr Julian Kelly Research Affiliate
Lorraine Kelpie Research Assistant
Ann Kempe Project Officer
Danielle Kibell PhD Scholar
Dr Sebastian King PhD Scholar
Dr Danijela Krmek Research Affiliate
Dr Sophie La Vincente Visiting Student
Sampo Lahtinen Research Affiliate
Ruth Lawrence Research Assistant
Stephanie Lenko Research Assistant
Paul Licciardi Research Assistant
Betty Lim Research Assistant
Dr Barry Linnane Research Affiliate
Catherine LloydJohnsen Research Assistant
Dr Elliot Long Study Doctor
Dr Jessica Luong Study Doctor
Ethna Macken Research Assistant
Carolyn MacLennan Research Affiliate
Danielle Marazzato Research Affiliate
Dr John Massie Honorary Fellow
Professor John Mathews Senior Principal Research Fellow
Dr James McCaw Honorary Fellow
AnnMarie McEvoy Research Assistant
Elizabeth McGrath Research Assistant
Jodie McVernon Honorary Fellow
Sarah Moberley PhD Scholar
Professor Kim Mulholland Honorary Fellow
Brian Muller Research Affiliate
Angelika Na Research Affiliate
Eva Nagy PhD Student
Paula Nathan Research Assistant
Jane Nelson Study Co-ordinator
Sophie Nightingale Visiting Research Fellow
Elanna Nolan
Administrative Assistant
Sara Noonan Research
Coordinator
Amanda O’Brien
Administrative Officer
Nyree O’Connor AMS Scholar
Dr Shane O’Dea Study Doctor
Kerry-Ann O’Grady Senior Research Officer
A/Professor Mark Oliver Honorary Fellow
Frances Oppedisano Research Assistant
Dr Nick Osborne Postdoctoral Fellow
Jacinta O’Sullivan Research Assistant
Dr Charnchai Panthongviriyakul Visiting Academic
Dr Monique Paris Honorary Fellow
Anne Peace Research Affiliate
Cristal Peck
Research Assistant
Dr Prue PereiraFantini Research Officer
Angela Pezic Research Assistant
Mairead Phelan
Administrative Assistant
Marisol Pineiro Research Affiliate
Dr Briony Price Study Doctor
Pamela Rhodes Research Assistant
Dr Nicole Ritz PhD Scholar
Dr Cameron Roberts Study Doctor
Dr Ric Roberts
Research Affiliate
Mary Roberts Research Affiliate
Dr Phil Robinson Honorary Fellow
Susi Rogers
Research Assistant
Dr Nicole Rose Study Doctor
Dr Simon Royce Postdoctoral Fellow
Dr Fiona Russell PhD Scholar
Jane Ryrie Research Assistant
Charan Sandhu
Research Assistant
Deborah Saunders Research Assistant
Clare Savage Research Affiliate
Dr Vered Schildkraut Research Assistant
Gowri Selvaraj
Research Assistant
Sally Sheridan Research Affiliate
Winnie Sim PhD Scholar
Serena Simms
Research Assistant
Di Simpson Research Affiliate
Billy Skoric
Research Assistant
Dr Joanne Smart Research Affiliate
Dr Arnold Smith Research Affiliate
Julie Smith Research Officer
Jacinta Sonego Research Assistant
Magdy Sourial Research Affiliate
Judith Spotswood Research Assistant
Patricia Staig Research Assistant
Dr Andrew Steer PhD Scholar
Dr Yulia Sugeng Study Doctor
John Sutcliffe Research Affiliate
Dayna Swiatek PhD Scholar
Dr Sepehr Tabrizi Research Affiliate
Juliana Tasevska Research Assistant
Dr Marija Tauschek Research Affiliate
Dr Michelle Teo Study Doctor
Dr Sharon Tennant Research Affiliate
Leone Thiele Research Affiliate
Dr Loretta Thorn Senior Research Fellow
Dr Jennifer Thomson Senior Research Fellow
Rina Triasih Masters Student
Dr Marisa TubridyClark Study Doctor
Eve Urban Research Assistant
Sarah Vaughan Research Assistant
Dr Claire Veith Study Doctor
Dr Kumar Visvanathan Research Affiliate
Dr Peter Vuilerman PhD Scholar
Dr Josef Wagner Research Officer
Sandra Walker Research Assistant
Dr Emily Walsh Study Doctor
Dr Annette Webb Research Affiliate
Marie West Study Doctor
Simone West Researcher / Occupational Therapist
Evan Willis Administrative Assistant
Dr Victor Wong Research Affiliate
Dr Ji Yang Research Affiliate
Tiam Yap Research Assistant
It’s not easy finding the right genes...
Discovering the genetic basis of disease and improving the prevention and management of genetic conditions including chromosomal diseases, ataxia, haemochromatosis, thalassaemia, muscular dystrophy and mitochondrial disorders.
Professor Andy Choo andy.choo@mcri.edu.au
We are in a strong position to achieve our mission, boasting excellent expertise and track record in molecular genetics, epigenetics, cytogenetics, clinical genetics, epidemiology, community genetics and genetics education.
The new theme structure and incentives has strengthened key collaborations for our researchers, who share a common interest in different aspects of laboratory, clinical, educational, and community genetics. We aim to develop a strategic vision and identify priority research areas that will build on the unique strengths and collective talents of the theme. To facilitate this, we have begun to establish important conceptual and operational policies to achieve better outcomes in research, publications, policy development, fund raising and grant success.
We undertake world-class research to advance our understanding of the causes of major health
problems for which a genetic or epigenetic basis exists or is suspected, and to develop measures to better detect, inform, prevent or correct these conditions.
We made significant progress in our laboratory, clinical and community genetics research in 2006.
In community research we completed a randomised controlled trial of a decision aid relating to prenatal testing for women early in pregnancy and commenced ironXS, a study which aims to screen 9000 high-school students for risk of the preventable iron overload disorder, haemochromatosis. We also made good progress on a study investigating the acceptability and feasibility of a population-based genetic screening program for inherited intellectual disability.
In clinical research, we established the clinical genetics research group in mid 2006, which aims to develop clinical genetics research at the Murdoch Childrens Research Institute. We also completed
studies examining clinical scales, eye movements, motor processing and quality of life for patients with the neurodegenerative disease Friedreich’s ataxia.
In laboratory research, we uncovered a candidate novel mechanism that explains the occurrence of Robertsonian translocation, which is the most common human chromosomal rearrangement.
We successfully developed the CND FISH assay for non-invasive diagnosis of Down syndrome using routine PAP smears. Our team also demonstrated the widespread genomic copy number changes in acute lymphoblastic leukaemia. We initiated a study on the effects of dietary levels on genome stability and identified a possible role of the PACRG gene in male infertility.
We also significantly advanced our work developing mouse models for mitochondrial Complex I deficiency and for evaluation of novel therapeutic strategies for the blood disorder thalassaemia and metabolic disorder methylmalonic aciduria.
Investment strategy
The key principle for theme investment was to drive new research initiatives and growth. We aimed to use the discretionary theme fund to support new, potentially higher-impact and higher-risk projects which require preliminary data before proceeding to external grant application. The theme fund is intended to encourage cross-group collaboration and recruitment of new high flyers who have the potential to significantly enhance our research and attract new external funding. A smaller part of theme investment was used to maintain general research activities not foreseen or covered by existing grants and to support key staff members who have encountered external funding shortfall.
Research outcome highlights
• Investigated the cause of spontaneous miscarriages with high throughput analysis using multiplex ligation dependent probe amplification (MLPA) subtelomere assays, demonstrating that MLPA assays are convenient, reliable and have a much lower failure rate than FISH tests
• Outlined the first comprehensive approaches to genetic counselling and prenatal diagnosis for any mitochondrial DNA mutation, resulting in all large mitochondrial centres internationally now discussing the reproductive options available to families with mitochondrial DNA mutations
• Successfully developed an effective decision aid for women considering prenatal testing of fetal abnormalities to help women make informed choices
• Participated on the expert Organization for Economic Cooperation and Development committee to establish minimum testing
standards for clinical use, accreditation of testing laboratories, qualifications of laboratory staff and a framework for countries that are establishing genetic testing programs
• Initiated the ironXS project, a continuation of the HaemScreen project, which involves screening year 10 and 11 high-school students for risk of the preventable iron overload disorder, haemochromatosis
Publications
The theme published 78 peer reviewed papers. Highlights were:
• Hui J et al. Developmental Medicine & Child Neurology 48: 132–136 (2006)
• Jaques AM et al. Journal of Medical Screening 13: 8–13 (2006)
• Kalitsis P et al. Proceedings of the National Academy of Sciences USA 103: 8786–8791 (2006)
• Nisselle AE et al. Clinical Genetics 69: 163–170 (2006)
• Vadolas J et al. Journal of Biological Chemistry 281: 7399–7405 (2006)
Awards & achievements
• Dr MaryAnne Aitken was a member of the coordinating group for the International Genetics Education Network
• Belinda McClaren was awarded a Melbourne Research Scholarship for 2006–2008
• A/Professor Sylvia Metcalfe was on the editorial board for the Community Genetics journal
• A/Professor Sylvia Metcalfe was founding chair of the International Genetics Education Network
• Emma Northrop was awarded a National Health & Medical Research Council Dora Lush (Biomedical) Scholarship
• Gabrielle Wilson received a National Health & Medical Research Council Dora Lush (Biomedical) Scholarship
In community research, we aim to increase understanding of the causes and impact of birth defects and examine measures on child health and wellbeing following genetic testing, particularly prenatal genetic testing. We will complete a study assessing midwives’ knowledge and practice of genetics, to inform an educational strategy, and we will continue research informing genetic counselling practice in the areas of family communication, predictive testing, health professional communication and attitudes to disability. Another major objective is to complete the screening of 3000 senior high-school students for risk of haemochromatosis in the ironXS study.
In clinical research, we will continue our study of measurement scales, heart, speech and motor processing in Friedreich’s ataxia, and commence new studies on using magnietic resonance imaging to investigate hearing processes.
We aim to commence recruitment for a Friedreich’s ataxia clinical trial in 2007 and will initiate new research into imprinting disorders, reproductive genetics, pharmacogenomics, genetic causes of intellectual disability, genetic counselling, the social and psychological impacts of genetic testing and the genetics of adult onset disorders including familial cancers.
In laboratory research, we will further our studies on the 18 drugs we have identified to increase frataxin levels with the ultimate goal of undertaking clinical trials in Friedreich’s ataxia.
We will advance our understanding of the function of PACRG and its role in Parkinson disease, male infertility and deafness, and commence a new project into the underlying pathogenesis of DYT1
dystonia. We will continue to develop in vitro and in vivo model systems to identify and evaluate pharmacological agents that can alter the effects of specific gene mutations in thalassaemia and methylmalonic aciduria.
In other laboratory research, we will continue to study novel mitochondrial genes and disease mechanisms. We will characterise the first mouse model for mitochondrial Complex I deficiency, which we recently developed, and use it to trial treatment strategies for severe childhood mitochondrial disorders and to understand roles of milder mitochondrial dysfunction in common diseases such as diabetes.
We will undertake further analysis of acute lymphoblastic leukaemia and multiple congenital abnormalities data to distinguish disease related changes from constitutional changes and fully develop the CND-FISH assay for non-invasive diagnosis of Down syndrome using routine PAP smears. We will study the effects of folate over or under-dose on genome instability, and will identify new genetic mechanisms underpinning the control of chromosome function and division.
Grants list
NHMRC
Project Grants
Andy Choo, Lee Wong, Richard Saffery
Chromosome & Chromatin
Research
$149,250
Paul Lockhart, Paul Thomas
Genetic Health Research (Bruce Lefroy Centre)
$152,500
David Thorburn
Mitochondrial & Metabolic Research
$145,875
David Thorburn, Michael Ryan
Mitochondrial & Metabolic Research
$165,250
Lee Wong, Andy Choo
Chromosome and Chromatin Research
$163,000
Fellowships
Andy Choo
Chromosome & Chromatin Research
Martin Delatycki
Genetic Health Research (Bruce Lefroy Centre)
Jane Halliday Public Health Genetics
Danielle Irvine
Chromosome & Chromatin Research
Denise Kirby
Mitochondrial & Metabolic Research
Paul Lockhart
Genetic Health Research (Bruce Lefroy Centre)
Heidi Peters Cell & Gene Therapy
David Thorburn
Mitochondrial & Metabolic Research
Jim Vadolas Cell & Gene Therapy
Lee Wong Chromosome & Chromatin Research
Scholarships
Michael Fahey
Genetic Health Research (Bruce Lefroy Centre)
Emma Northrop
Chromosome & Chromatin Research
Michelle Seipolt
Genetics Education & Health Research
Gabrielle Wilson
Genetic Health
Research (Bruce Lefroy Centre)
EXTERNAL GRANTS
Project Grants
ANZ Medical Trusts
Merle Spriggs
Genetics Education & Health Research
$57,434
Australian Stem Cell Centre
Bennett Foddy Ethics
$19,275
Department of Human Services
Veronica Collins Public Health
Genetics
$51,000
Department of Human Services
Jane Halliday Public Health
Genetics
$10,458
March of Dimes Birth Defects Foundation
Andy Choo
Chromosome & Chromatin Research
$56,219
Muscular Dystrophy Association USA
Joseph Sarsero Cell & Gene Therapy
$27,111
Muscular Dystrophy Association USA
Joseph Sarsero
Cell & Gene Therapy
$65,309
Muscular Dystrophy Association USA
David Thorburn
Mitochondrial & Metabolic Research
$89,555
National Institute of Health
Andy Choo
Chromosome & Chromatin Research
$US250,000
Perpetual Trustees
Evelyne Muggli Public Health
Genetics
$44,775
The Cass Foundation Limited
Heidi Peters
Cell & Gene Therapy
$17,500
The Heart Foundation
Veronica Collins
Public Health
Genetics
$39,144
Travel Grants
Cancer Council
Victoria
Sylvia Metcalfe
Genetics Education and Health Research
$8480
Ian Potter
Foundation
Jim Vadolas
Cell & Gene Therapy
$2000
MCRI INTERNAL GRANTS
Project grants
Martin Delatycki, Katie Allen, Veronica Collins, Sylvia Metcalfe, Mary-Anne Aitken, Desiree Du Sart
Genetic Health Research
$30,000
Jane Halliday, George
MCGillivray, Shelly Rowlands, Veronica Collins
Public Health
Genetics
$25,000
Heidi Peters, Katie Allen, James Pitt, Nicole PettigrewBuck
Cell & Gene Therapy
$61,000
Nick Wong, Richard Saffery, Lee Wong, Andy Choo Chromosome Research
$65,000
Staff list
THEME DIRECTOR
Professor Andy Choo
Talitha Fraser Personal Assistant to Theme Director
Vivienne Gorman
Personal Assistant to Theme Director
THEME ADVISORY GROUP
Cell & Gene
Therapy
Dr Jim Vadolas
Dr Heidi Peters Chromosome & Chromatin Research
Professor Andy Choo
Clinical Genetics
Research
Dr David Amor
Cyto-Molecular Diagnostics Research
A/Professor
Howard Slater
Dr Desirée du Sart Genetic Health Research (Bruce Lefroy Centre)
A/Professor Martin Delatycki
Genetics Education & Health Research
A/Professor Sylvia Metcalfe
Dr MaryAnne Aitken
Mitochondrial & Metabolic Research
A/Professor David Thorburn
Public Health
Genetics
A/Professor Jane Halliday
Soyeon Ahn PhD Scholar
Melissa Anderson
Research Assistant
Alison Archibald Masters Scholar
Alison Arvaj
Medical Scientist
Sheena Bailey PhD Scholar
Varlli Beetham Research Assistant
Michelle Bishop PhD Scholar
A/Professor Avihu Boneh
Metabolic Physician
Kate BrettinghamMoore
Postdoctoral Fellow
Kate Brody Research Assistant
Damien Bruno PhD Scholar
Yasmin Bylstra Project Officer
Breana Cham Masters Scholar
Kasey Chan
PhD Scholar
Lyn Chan
PhD Scholar
Sherry Chang PhD Scholar
Dr Belinda Chong
Senior Medical Scientist
Anderly Chueh PhD Scholar
Dr Veronica Collins
Senior Research Officer
Louise Corben
Clinical Research
Coordinator
Ailsa Cranfield
Medical Scientist
Debbie Davis
Administrative
Assistant
Dr Lesley Donelan Research Assistant
Elizabeth Earle Research Officer
Dr Michael Fahey PhD Scholar
Bennett Foddy PhD Scholar
Laura Forrest PhD Scholar
Ivan Francis Senior Medical Scientist
Lydia Gaffney Administrative Officer
Anne Glynn Research Fellow
Dr David Godler
Postdoctoral Fellow
Melanie Gow Research Assistant
Dr David Grubb Research Fellow
Chriselle Hickerton
Masters Scholar
Jan Hodgson PhD Scholar
Timothy Holloway Research Assistant
Sara Howden
PhD Scholar
Maureen Humphrey Metabolic Dietician
Dr Alice Jaques
Postdoctoral Fellow
Dr Paul Kalitsis Senior Research Officer
Jolanta Karpowicz Laboratory Technician
Dr Mahmoud Khaniani
PhD Scholar
Dr Denise Kirby Research Fellow
Jenny Kozlovski Honours Student
Adrienne Laskowski Research Assistant
Dr Sharon Lewis
Senior Research Officer
Lingli Li Research Officer
Lara Lipton
Associate Fellow
Dr Paul Lockhart Senior Research Fellow
Dr Sima Mansooriderakhshan PhD Scholar
Owen Marshall PhD Scholar
James McGhie Research Assistant
Belinda McClaren
PhD Scholar
Ava Mishra Medical Scientist
Evelyne Muggli Research Officer
Catherine Nagle Research Officer
Steven Nasioulas
PhD Scholar
Amy Nisselle PhD Scholar
Emma Northrop PhD Scholar
Erin Oldaker Research Assistant
Samuel Pennell
AMS Scholar
Mark Pertile
Senior Medical Scientist
Novita Puspasari PhD Scholar
Dr Hua Ren Research Affiliate
Felicity Rodda Research Affiliate
Dr Renato Salemi Research Fellow
Dr Joseph Sarsero Research Fellow
Adrienne Sexton
Masters Scholar
Marcus Sim Honours Student
Dr Merle Spriggs Postdoctoral Fellow
Canny Sugiana PhD Scholar
Cynthia Susanto AMS Scholar
Dr Juliet Taylor Research Fellow
Simone Tregoning Research Assistant
Dr Kaye Trembath Clinical Research Coordinator
Michiel van Werkhoven
Research Assistant
Adam Vogel Research Assistant
Joanna Voon PhD Scholar
Lucille Voullaire Medical Scientist
Hady Wardan Research Officer
Emma Weisz AMS Scholar
Evan Williams Research Assistant
Gabrielle Wilson PhD Scholar
Cate Wilson Research Assistant
Michelle Wolthuizen
Project Coordinator
Dr Lee Wong Senior Research Officer
Leonie Wood Research Assistant
Mary-Anne Young Masters Scholar
Taking a step in the right direction, together
Our research into conditions such as arthritis, bone dysplasias, cerebral palsy, muscular dystrophy, craniofacial abnormalities and dental problems will improve diagnosis and provide new therapies to improve patient care.
Professor John Bateman john.bateman@mcri.edu.au
Theme overview
By studying the developmental pathways of cartilage, bone and craniofacial and oral disorders, we will provide new and improved preventative and treatment strategies. We have an exciting synergy between laboratory, clinical and public health researchers, which will lead to improvements in the lives of children and families affected by these conditions.
priorities
• We characterised gene mutations that cause inherited craniofacial, bone, cartilage and muscle diseases and determined the molecular basis of how these mutations affect normal tissue structure and function
• We studied the molecular basis of the onset and progression of cartilage destruction in arthritis, a major problem in children as well as adults. Our research explored the gene and protein expression changes and determined cartilage degrading enzymes and their substrates. Our clinical research focused on determining outcomes and best clinical practice in juvenile arthritis
• Our research sought to understand normal craniofacial development and the causes of craniofacial birth defects such as cleft lip and palate and how these impact on the child, their quality of life and their families
• We determined the natural history of early childhood tooth decay and the socio-cultural determinants of public dental health. We studied developmental defects of teeth and new approaches to clinical management
• Gait analysis was used to understand the biomechanics and walking patterns of children with musculoskeletal injury or disease. These studies, on diseases such as cerebral palsy, helped improve clinical decision making and brought together genetics, gait analysis and surgical correction for children with skeletal dysplasias to provide better patient outcomes
Our theme investment strategy was to leverage grant funding and to allocate internal resources in three key areas:
• Strategic investment in important research equipment, technologies and core facilities, which included a musculoskeletal genetic testing laboratory
• Internal project grants to support pilot studies and establish new research directions
• Short-term funding to enhance career stability and opportunities for young researchers and to attract high-quality researchers to develop research in priority areas
Research outcome highlights
• The Centre for Clinical Research Excellence in Clinical Gait Analysis & Gait Rehabilitation developed and introduced new gaitmeasurement tools into routine clinical practice. Gaitabase, a web-based tool that evaluates gaitmeasurement performance, was also developed and is now accessible on the internet
• Research into skeletal biology and disease resulted in new genetic and prenatal diagnostic tests for Stickler syndrome and muscular dystrophy
• Our researchers who first discovered the enzyme responsible for cartilage degradation in arthritis, conducted further research to explore the regulation of enzymes to aid in the development of specific inhibitors to manage arthritis
• Ongoing research into botulinum toxin and surgical management of cerebral palsy resulted in children with cerebral palsy being able to walk better
• Conducted new surgical research to investigate hip disease, a common cause of movement problems, which results in children attending the gait analysis clinic
• The functional mobility scale developed by the Gait Centre for Clinical Research Excellence was adopted by centres in Auckland, Chicago and Toronto and was translated into five languages for worldwide use
• Our oral health research team established ways to improve oral health and reduce decay for children living in rural areas and resulted in a better understanding of the barriers to
Publication highlights
The theme published 38 peer reviewed papers. Highlights were:
• Belluoccio D et al. Proteomics 6: 6549–6553 (2006)
• Allen JM et al. Journal of Biological Chemistry 281: 7341–7349 (2006)
• Lamandé SR et al. Journal of Biological Chemistry 281: 16607–16614 (2006)
• Soo, B et al. Journal of Bone & Joint Surgery — American Volume 88: 121–129 (2006)
• Reid J et al. Cleft Palate — Craniofacial Journal 43: 702–709 (2006)
Awards & achievements
• Professor John Bateman was president of the International Society for Matrix Biology
• A/Professor Leo Donnan was awarded an International Ilizarov Fellowship
• A/Professor Amanda Fosang was awarded the Murdoch Childrens Research Institute Discovery Award for excellence demonstrated in research for senior researchers 10 years or more postdoctoral
• Professor Kerr Graham was the editor for orthopaedics for the journal, Developmental Medicine & Child Neurology
• Professor Kerr Graham was board member for the Journal of Children’s Orthopaedics
• Dr Peter Kannu was awarded a Sir Gustav Nossal Scholarship from the National Health & Medical Research Council
• Dr Shireen Lamandé was vice president of the Matrix Biology Society of Australia and New Zealand
• Dr Jane Munro received a National Institute of Clinical Studies Fellowship
• A/Professor Ravi Savarirayan was section editor for the European Journal of Human Genetics
• A/Professor Amanda Fosang was editor for the Journal of Biological Chemistry
• To develop strategies to support and enhance our research performance
• To foster new initiatives to help us achieve our mission of conducting world class research into musculoskeletal and craniofacial development and disease
• To translate our research into improved diagnosis, prevention and patient care
• To encourage research interactions between researchers in our musculoskeletal disorders theme, foster national and international interactions to maximise our impact on child health
• To provide pilot project funding and mentoring to increase our external grant funding
Grants list
NHMRC
Centre for Clinical Research Excellence
Kerr Graham
Orthopaedics & Gait Analysis
$400,000
Project Grants
John Bateman, Jamie Fitzgerald
Skeletal Biology & Disease
$170,750
John Bateman, Chris Little, Amanda Fosang
Skeletal Biology & Disease
$149,500
Peter Farlie, Don Newgreen Craniofacial Research
$116,000
Shireen Lamandé, John Bateman, Kathryn North Muscular Dystrophy
$191,500
Fellowships
Peter Farlie
Craniofacial Research
Nicky Kilpatrick Oral Health Research
Scholarships
Negar Jamshidi Craniofacial Research
Peter Kannu
Skeletal Biology & Disease
Tam C Nguyen
Orthopaedics & Gait Analysis
Kar Mun Chan Oral Health Research
EXTERNAL GRANTS
Program Grant
Hugh Williamson Foundation
Kerr Graham
Orthopaedics & Gait Analysis
$100,000
Project Grants
Arthritis Foundation of Australia
Daniel McCulloch
Arthritis & Rheumatology
$15,000
Equity Trustees
Bev Eldridge
Orthopaedics and Gait Analysis
$25,250
The Jack Brockhoff Foundation
Jane Munro, Tria Williams
Arthritis & Rheumatology
$177,000
Muscular Dystrophy
Association US Shireen Lamandé
Muscular Dystrophy
$52,864
The Rebecca Cooper Medical Research Foundation
Limited
Daniel McCulloch
Arthritis & Rheumatology
$15,000
Royal Australasian College of Physicians
Jane Munro
Arthritis & Rheumatology
$24,200
Scholarships
Arthritis Foundation of Australia
Stephanie Gauci
Arthritis & Rheumatology
$20,000
MCRI INTERNAL GRANTS
Project grants
Kerr Graham, Richard Baker, Karen Dodd, Nick Taylor
Orthopaedics & Gait Analysis
$48,000
Shireen Lamandé, Kathryn North Cell & Matrix
$54,000
Postgraduate Health Research Scholarships
Adrienne Harvey Orthopaedics & Gait Analysis
Staff list
THEME DIRECTOR
Professor John Bateman
Shirley D’Cruz
Personal Assistant to Theme Director
THEME ADVISORY GROUP
Arthritis & Rheumatology
A/Professor
Amanda Fosang
Craniofacial Research
Dr Peter Farlie
Muscular Dystrophy
Dr Shireen
Lamandé
Oral Health Research
A/Professor Nicky Kilpatrick
Orthopaedics & Gait Analysis
Leo Donnan Professor Kerr Graham
Dr Richard Baker
Skeletal Biology & Disease
Professor John Bateman
A/Professor Ravi Savarirayan
THEME MEMBERS
Naomi Adams Research Assistant
Dr Roger Allen Honorary Fellow
Dr Justin Allen
Postdoctoral Fellow
Dr Firas Alsoleihat Research Affiliate
Anne Augustine Nurse Educator
Dr Naomi Baker Research Officer
Dr Richard Baker
Gait Analysis
Service Manager
Dr Jitendra Balakumar
Research Affiliate
Dr Edward Bastow
Research Affiliate
Dr Daniele
Belluoccio
Postdoctoral Fellow
Bianca Bernardo PhD Scholar
Dr Andrea
Bialocerkowski Honorary Fellow
Cvetanka
Bogoeska Research Affiliate
Dr Bent Brachvogel Visiting
Postdoctoral Fellow
Glen Burke Research Affiliate
Trevor Cameron
PhD Scholar
Dr Kar Mun Chan PhD Scholar
Alan Corral
Technical Assistant
Marie-Anne
DePetro
Research Affiliate
Cheryl Dingey
Research Affiliate
Fiona Dobson PhD Scholar
Charlotte East PhD Scholar
Bev Eldridge Research Affiliate
Adrienne Fosang Research Affiliate
Stephanie Gauci PhD Scholar
Suzanne Golub Research Affiliate
Dr Christopher Gordon
Postdoctoral Fellow
Irma Gresshoff Research Affiliate
Adrienne Harvey PhD Scholar
Tandy HastingsIson Research Officer
Dr Melita Irving Visiting Researcher
Dr Negar Jamshidi PhD Scholar
Michael Johnson Research Affiliate
Dr Peter Kannu
Clinical Geneticist
Freiderike Kremer Research Affiliate
Leonie Kurth
Technical Assistant
Karena Last Research Affiliate
Susan Liew
Research Affiliate
Jennifer McGinley Research Officer
Dr Michael McMullan Research Affiliate
John Meara Honorary Fellow
Professor Meg Morris
Associate Fellow
Dr Jane Munro
Senior Research Officer
Gary Nattrass Honorary Fellow
Dr Ana Neumann
Research Assistant
Nicholas Opie Technical Assistant
Mark O’Sullivan Research Affiliate
Rishika Pace PhD Scholar
Dr Arpit Patel Research Affiliate
Alana Peters
Research Affiliate
Dr Christopher Poon
Postdoctoral Fellow
Dr Jonathan Robin
Clinical Research
Fellow
Jill Rodda
Research Affiliate
Dr John Rogers
Research Affiliate
Dr Fraser
Rogerson
Research Affiliate
Lynn Rowley
Research Assistant
A/Professor Ravi Savarirayan
Clinical Geneticist
Paulo Selber
Research Affiliate
Mary Sheedy
Research Affiliate
Dr Brendan Soo
Research Officer
Dr Heather Stanton Honorary Fellow
Dr Tiong Yang Tan
PhD Scholar
Dr KateTaylor Research
Psychologist
Pam Thomason
Senior Research Officer
Dr Oren Tirosh
Postdoctoral Fellow
Leona Tooley Honours Student
Sharon Vladusic
Research Affiliate
Prue Weigall
Research Affiliate
Tria Williams
Project Officer
Dr Richard Wilson
Postdoctoral Fellow
Dr Jacqueline Wong
Postdoctoral Fellow
Laura Zamurs
Research Assistant
Supporting our research themes and groups by providing expertise in the areas of biostatistics, bioinformatics and clinical trials.
The Clinical Epidemiology and Biostatistics Unit (CEBU) provides a range of training and research support covering study design, statistics and data management, to researchers at the Murdoch Childrens Research Institute.
epidemiological studies, major new collaborations on a range of studies related to childhood obesity, infant sleep problems and early hearing and language development, a report of a large international study on signs and symptoms that predict severe illness in very young infants, and a new international clinical trial on possible neurodevelopmental effects of anaesthesia in young children.
• Susan Donath became Deputy Editor of a newly established international journal, the International Breastfeeding Journal
• Dr John Galati spoke on the disease burden of rotavirus at the National Centre for Immunisation Research Rotavirus Symposium held at the University of Sydney
• Pollyanna Hardy published an invited commentary in Biology of the Neonate
Carlin
In 2006 CEBU continued to provide a wide range of contributions to research within the six themes of MCRI and beyond. We worked with more than 50 groups and departments on the Royal Children’s Hospital campus, engaging in more than 150 different research projects.
Our contributions ranged from advice on research methods and statistics through to large scale collaborations on major community based studies into common health problems in children and adolescents. Our program of short courses attracted 370 attendees across nine courses.
Specific research highlights included the continuation of National Health & Medical Research Council funded work on methods for dealing with missing data in large
• CEBU published 45 articles in scientific journals including numerous collaborative studies on paediatric clinical problems and a major review of twin study analysis in the International Journal of Epidemiology
• Professor John Carlin, Susan Donath and Dr Obioha Ukoumunne were chief investigators on four successful National Health & Medical Research Council project grant applications
• Professor John Carlin received an award for Excellence in Teaching and Learning in the School of Population Health, University of Melbourne
• Professor John Carlin was an invited speaker at the International Biometrics Conference in Montreal, where he presented on multiple imputation
• Katherine Smith was a key co-author of an early thematic report for the Australian government investigating children’s development
The Australian Paediatric Research Unit (APPRU) conducts clinical trials in children to investigate the safety and effectiveness of prescription drugs and medications typically developed for adults, to improve the safety and efficacy of therapies for children.
Group Leader, A/Professor Noel Cranswick
We perform high quality, timely, clinical diagnosis in children, that complies with local and international good clinical practice guidelines. Our primary focus is always on the quality use of medicines in children.
We continued to provide clinical trials services and personnel who are highly experienced in Phase I to phase IV trials and issues relating to good clinical practice, CRF management and subject recruitment.
We also provided clinical pharmacology, research and development, clinical trial design and protocol development, good clinical practice compliance, pharmacokinetic and pharmacodynamic modelling and regulatory affairs strategy.
Highlights
• Collaborated on numerous clinical drug trials, including phase I to phase IV studies, single centre and international multi centre trials and a number of pharmacokinetic, bioequivalence and pharmacodynamic studies
• Implemented a medication in schools policy for both primary and secondary schools in Victoria
• Facilitated public and media debate on the use of Complementary and Alternative Medicines in children
• Collaborated with the World Health Organization and UNICEF on the development of a paediatric Essential Medicines List
• Continued early phase studies in children in metabolic disease, skin disease, allergy, vaccines, musculoskeletal and neurological disease
Grants
NHMRC PROjECT GRANTs
john Carlin
Clinical
Epidemiology and Biostatistics (CEBU)
$66,000
NHMRC
sCHOLARsHIPs
Patty Chondros CEBU
ExTERNAL GRANTs
Save the Children
Professor
john Carlin CEBU
$5920
World Health Organisation Professor
john Carlin CEBU
$5920
staff list CEBU
Professor
john Carlin Group Leader
Claudine Chionh Research Assistant
Patty Chondros PhD Scholar
Donna De sair Administrative Officer
susan Donath Senior Research Fellow
Dr john Galati Research Officer
Pollyanna Hardy Biostatistician
Dr Rajalingam sivakumaran Research Officer
Dr sue skull Honorary Fellow
Katherine smith Research Assistant
Dr Obioha Ukoumunne Senior Research Officer
suzanna Vidmar Senior Research Assistant
BIOINFORMATICs
Dr Katrina Bell Bioinformatics Officer
Lavinia Gordon Bioinformatics Officer
APPRU
A/Professor Noel Cranswick Group Leader
Dr sean Beggs Research Affiliate
Rebecca Cerbu Administration Assistant
Elissa Giddings Clinical Trial Coordinator
Dr Emma Magrath Research Fellow
shannon Power Clinical Trial Coordinator
Formally acknowledging and rewarding our high achievers for their exceptional commitment to the values and mission of Murdoch Childrens Research Institute.
The passion, dedication and commitment of our researchers is the driving force behind the major discoveries we make to improve the health and wellbeing of children, here and around the world.
Our new achievement awards recognised the exceptional commitment of our high achievers in four categories: the discovery award, the rising star award, the innovation award and the teamwork award.
The discovery award
For excellence demonstrated in research in 2005, for senior researchers 10 years or more postdoctoral.
A/Professor Amanda Fosang Musculoskeletal Disorders
Arthritis & Rheumatology
Amanda was recognised for her outstanding research, which identified the cause of cartilage degradation in arthritis. The world-first finding, published in the prestigious journal Nature, will lead to the development of new therapies to prevent cartilage destruction in arthritis patients, young and old.
Amanda is internationally recognised for her longstanding research on the molecular basis of arthritis, which affects four in 1000 children. She has given many plenary lectures at international meetings, which is testament to the high international standard of her work.
The rising star award
For excellence in research, for researchers less than 10 years postdoctoral.
A/Professor Melissa Wake Healthy Development Centre for Community Child Health, Public Health Hearing
Melissa’s outstanding public health research led to seven peer-reviewed papers being published in 2005, in journals including in The Journal of the American Medical Association and the Archives of Disease in Childhood.
She was also very successful in obtaining new funding for her research, receiving three new grants from the National Health & Medical Research Council (NHMRC) and two grants from the Australian Research Council. This is in addition to existing grants and a population health career development award from NHMRC. Melissa also has an outstanding track record of translating research into policy and practice.
The innovation award
For outstanding innovation in research support, for staff in research or corporate services.
Dr Kerry Fowler Disease Models
Mr George Teng & Mr Stanly Ho Information Technology
The trio worked with the Bureau of Animal Welfare to develop two unique web-based systems for the mandatory tracking and reporting of animals used in medical research. The system has been implemented successfully at the Murdoch Childrens Research Institute and is likely to be taken up by other research institutes.
The teamwork award
For exceptional commitment to helping the institute achieve its mission.
Dr Jeff Craig Early Development & Disease Epigenetics Research
Jeff made substantial contributions to areas exceeding his own research specialisation, including advocacy activities, membership on internal committees and participation in fundraising events, media and public relations activities.
We believe that because our students could one day be world leading medical researchers, we must provide them with the best opportunities for learning and development.
Murdoch Childrens Research Institute is committed to nurturing medical researchers and places a strong emphasis on investing in future leaders. The institute encourages a supportive working environment where students interact with senior scientists and
Both Honours and PhD research students are recruited from leading Australian universities, within medical, surgical, nursing and allied health fields to ensure high
Postgraduate Students’ Association
Encouraging learning, development and interaction between students from MCRI, The University of Melbourne’s Department of Paediatrics and The Royal Children’s Hospital. In 2006 the association hosted several academic seminars, short courses, social activities and the annual retreat, to provide
Meet young researcher Andrea Harrington Infection, Immunity & Environment
After completing a Bachelor of Science, Andrea joined the Murdoch Childrens Research Institute in 2003 to complete Honours in gut motility research. She is currently in her final year of her PhD.
Explain your research
students with opportunities to share experiences and improve their skills. A new student induction day was introduced and with the Postdoctoral and Clinical Trainee Association developed a mentoring scheme. An IT policy for students was established and the students section of the website was developed further.
In conjunction with Roche Applied Science, the Roche Project Award to support new research conducted by a postgraduate student was established. In 2006, the award was won by Winnie Sim of Infection, Immunity & Environment for her research into the cause of Crohn’s disease.
PRESIdENT
Andrea Harrington Infection, Immunity & Environment
TREASURER
Sara Howden Laboratory & Community Genetics
SECRETARy
Alicia Spittle Critical Care & Neurosciences
PROMOTIONS & MARkETINg OffICER
Amy Nisselle Laboratory & Community Genetics
gENERAL OPERATIONS
dayna Swiatek Infection, Immunity & Environment
Hsiao Voon Laboratory & Community Genetics
Two-hundred children are admitted to the Royal Children’s Hospital each year with chronic constipation that does not respond to treatments. My project involves investigating if there is a defect in the neurons and nerves controlling muscle activity within the colon wall of these children by examining the circuitry (neurons, neurotransmitters and receptors) controlling intestine muscle contraction. Our research will help improve the understanding of this condition and lead to better diagnosis and treatment.
Research career highlights
Attending and presenting at three international conferences, having three papers published and discovering new things! Being awarded the American Motility Society Young Investigator Travel Award and the Australia Neuroscience Society Travel Award in 2006.
Biggest satisfaction with science
It is never boring! I am always learning new skills. I enjoy that research offers variable work opportunities, you can be in the laboratory one day, writing manuscripts the next and you can even end up in management or educational roles. The opportunity to travel is also a major plus.
The Post-doctoral & Advanced Clinical Trainee Association offers peer support and social interaction, improving links between clinical and research fellows to provide educational and professional development opportunities.
Financial contributions from MCRI and RCH support the association’s activities, including awarding an annual travel grant to a clinical trainee or a postdoctoral fellow to attend a conference of their choice.
After surveying members to gauge interest, assess perceptions and value, PACT became involved in the development of a mentoring program for research and research support staff. It is anticipated that a pilot mentoring program will be launched in 2007.
A series of career development seminars including tips for writing research grants, consent issues in clinical genetics and genetics research and an information evening on research and higher degrees for clinical fellows were successful.
Meet young researcher Angela Morgan Phd
Critical Care & Neurosciences, Healthy development
Angela recently returned to Australia, following three years post doctoral work at the Institute of Child Health, University College London (UCL). She works with Professors Sheena Reilly and Vicki Anderson.
Approximately 9 per cent of children experience some form of speech sound disorder, disrupting the basic human need for communication. There are two main forms of speech disorder: developmental and acquired (due to brain injury post-motor vehicle accident, stroke or tumour).
Despite their prevalence, we have limited understanding of the neural or biological bases for why speech disorder occurs. A better understanding will enable more informed diagnosis, treatment and overall management of speech disorder.
I am currently involved in a neuroimaging project (using latest MRI technology) to investigate developmental stuttering. During my UK experience I trained in functional neuroimaging and quantitative speech analysis techniques.
Research career highlights
My neurosciences lectureship at the Institute of Child Health UCL. The experience was inspiring and challenging and provided me with great opportunities to learn from leading experts.
Biggest satisfaction with science
PRESIdENT
Sharon Lewis (Post doctoral co-president) Laboratory & Community Genetics
Mary Herzig (Clinical co-president, January – August 2006)
Infection, Immunity & Environment
Nigel Crawford (Clinical co-president, September – December 2006) Infection, Immunity & Environment TREASURER
Juliet Taylor Laboratory & Community Genetics
SECRETARy
Veronica Collins Laboratory & Community Genetics
MEMBERS
Alice Jaques Laboratory & Community Genetics
Pater kannu Musculoskeletal Disorders
Renato Salemi Laboratory & Community Genetics
Shehnaaz Manji Early Development & Diseases
Simon Royce
Infection, Immunity & Environment
I began my career working clinically and was driven to focus on research due to the gap between theory and practice. So my biggest inspiration and reward in science is being able to study and understand more about the mechanisms of speech disorders so we may try to directly inform and improve diagnosis or management of patients in clinical practice.
Genetic Health Services Victoria is the state’s primary provider of testing, counselling and support for genetic conditions. VCGS Pathology provides newborn screening for all babies born in Victoria, genetic screening and diagnostic services for intellectual diability, birth defects, metabolic disorders, neurological disorders and inherited cancer. Scientists at VCGS Pathology work closely with clinicians at Genetic Health Services Victoria to ensure tests are accurately interpreted.
Genetic Health Services Victoria also delivers accredited courses to doctors and counsellors and provides ongoing professional development. Research is conducted in partnership with the Murdoch Childrens Research Institute to promote the development of new tests, technologies and genetic knowledge.
Providing fully integrated and accessible genetic screening and diagnostic services, counselling and support, with a commitment to research, education and client services of the highest standard.
Director: Professor Agnes Bankier agnes.bankier@ghsv.org.au
We have been helping the people of Victoria make informed decisions about their health and wellbeing for more than 40 years yet many people, including professionals, still don’t know who we are and what we do. Perhaps this is not surprising, given that as the sole service provider in many areas of operation, developing a strong profile has not been a priority.
Following a strategic planning session in July 2006, we engaged Fenton Communications to help us develop our communications strategy and media strategy, to increase awareness about our services in 2007 and beyond.
The workshop was attended by members of the VCGS board and our senior staff. We thank them for contributing to this important meeting. Our strategy affirmed that being part of the Murdoch Childrens Research Institute is greatly valued by our staff
and provides unique opportunities for research and for developing new tests and genetic knowledge for the benefit of all.
Genetic Health Services Victoria continues in its commitment to deliver accessible clinical genetic services of the highest standard in Victoria and Tasmania to people of all ages. The Department of Human Services (DHS) shares our aim of equity of access to services and has provided enhanced funding for the delivery of cancer genetic services to regional Victoria.
By reprioritising existing resources, and through collaboration with stakeholders, we have been able to establish new cardiac genetics services for children and adults, and have extended genetic services for Austin Health. Through a successful joint application with Austin Health to the DHS we are now able to appoint a genetic counsellor to that site.
Our diagnostic laboratories, VCGS Pathology, provide screening and diagnostic services. There are five laboratories providing DNA testing and chromosome analysis, maternal serum screening for pregnant women, newborn screening and metabolic tests. Our strategy affirmed the importance of an integrated pathology service, badged as VCGS Pathology. We developed a new website and released the first of regular bulletins to keep our referring doctors up-to-date with activities. We are working towards a common specimen reception and laboratory information system. We are pleased with the success of our cystic fibrosis screening program and we are continuing our efforts to seek funding to increase its availability throughout the whole community.
In collaboration with hematologists from the Alfred and Children’s Hospitals, the VCGS has been successful in obtaining funding from the DHS for haemophilia gene testing. We have also secured new funding for genetic tests for rare disorders which need to be purchased from interstate and overseas.
Dr June Danks launched POSSUM Web a new web-based version of the well known POSSUM database at the International Congress of Human Genetics in August 2006. Initially developed in 1986 POSSUM is a database that helps doctors worldwide to diagnose individuals with various patterns of birth defects. After extensive testing by more than 40 centres internationally, the web database will become available for use in March 2007 following the Annual Clinical Genetics Meeting in Nashville, USA.
Another major effort has been the documentation of credentials for all our staff and their honorary appointment to major hospitals where genetic services are delivered. VCGS is also negotiating and reviewing specific service agreements at those sites to clarify mutual contributions and obligations to genetic service delivery.
In addition to clinical and laboratory service provision we played a key role in genetic education of the
future genetic workforce through training geneticists and genetic counsellors. We welcome trainees from interstate and overseas, who enrich our activities.
Two staff members gained academic recognition, with Howard Slater and Mac Gardner being awarded Associate Professorships by the University of Melbourne. Now six of the 10 VCGS staff Clinical Geneticists have Professorial titles. Professor Ingrid Winship was appointed Professor of Adult Genetics at the University of Melbourne. We congratulate her on this appointment and wish her every success.
An important development in 2006 was the establishment of the DHS Genetic Services Advisory Committee, which aims to define the genetics service needs of Victoria with the view of applying to the State for new funding to ensure these needs are met in the most appropriate manner. Three working groups have been established including Genetic Service Development, which I Chair, and Family Cancer Genetic Services and Genetic Education.
The outcomes and recommendations developed by these working groups and the Advisory Committee will be determine Victoria’s Genetic Service Strategy for the next five years and will have great significance for Genetic Health Services and VCGS Pathology. We will strive to ensure that decisions are evidence based and driven by the needs of the people of Victoria.
Professor Agnes Bankier Director
Genetic Health Services Victoria & VCGS Pathology
Genetic Health Services Victoria
www.genetichealthvic.net.au
03 8341 6201
VCGS Pathology
www.vcgspathology.com.au
03 8341 6201
• Reproductive genetic services were provided through the Royal Women’s Hospital, Monash Medical Centre, The Mercy Hospital for Women, Northern Hospital and Melbourne IVF. We will commence new services at Monash IVF and Western Health in 2007
• Identified need and initiated plans to provide the full range of genetic services to Heidelberg, as provided in Clayton and Parkville. Pediatric cardiac genetic services commenced at the Royal Children’s Hospital and adult cardiac services at the Royal Melbourne Hospital. Once funding is available, we will look to extending these services to other major precincts
• Integrated screening and diagnostic laboratory services under the umbrella of VCGS Pathology
• Continued efforts to upgrade the equipment in all laboratories, which has been part of a five year strategy to re-equip our laboratories with state of the art equipment to deliver cost efficient laboratory diagnosis and screening programs in a timely manner
• Introduced computerised imaging to the cytogenetics laboratory, robotics to gene testing and automatic hole punchers to the newborn screening laboratory
• The following people joined us from interstate and overseas to advance their genetics training: Dr Stan Korman (Israel), Dr Alison Cozens (UK), Dr Melita Irving (UK), Dr David Coman and Dr Tiong Tan (QLD) and Dr Nicholas Pachter (South Africa)
• VCGS provided leadership in undergraduate genetic education through the joint Monash/ Melbourne Curriculum Advisory Committee. With assistance from Dr Wiji Nadesapillai we mapped the existing curricula and through focus groups and workshops developed recommendations for core competencies and teaching. The information is being reviewed by the curriculum committees of the respective medical schools and was also sent to the National Health & Medical Research Council Human Genetic Advisory Committee and to the Committee of Deans of Australian Medical Schools, with the view of providing national recommendations for undergraduate genetic education for medical students. The Graduate Diploma for Genetic Counsellors gained international recognition and we now have overseas students in our course
• Investigated possibility of providing a Masters Program in line with international advances in this field
• Staff were appointed to the executive and committees of the Human Genetic Society of Australasia and its training programs and quality assurance programs
• Our staff delivered over 200 talks about genetics to universities and hospitals and provided professional development programs for general practitioners and other professionals in metropolitan and regional centres
The majority of VCGS’s research activities fall under the Laboratory & Community Genetics Research Theme of the Murdoch Childrens Research Institute.
Our staff have contributed significantly to the research activities (see full listing of publications on pages 60–67).
• VCGS staff contributed to more than 10 per cent of the institute’s publications and were cited as first or last author in 60 per cent of these. This outstanding effort demonstrates our recognition of the importance of performing research to seek ongoing improvements, in what is already a first class clinical service
• Our staff received funding which allows them to dedicate time to research activities: A/Professor Martin Delatycki, director of the Bruce Lefroy Centre and Dr David Amor, Clinical Research Leader (funding received from MCRI), Dr Heidi Peters, Research Officer, gene therapy (funding received from NHMRC), A/Professor Les Sheffield, pharmacogenetics research (funding received from MCRI)
• Hosted the Australasian Pharmacogenetics Interest Group meeting and the first Australian Meeting for Fibrodysplasia Ossificance Progressiva, shortly after the identification of the gene for this condition.
Dr John Rogers was co author of this publication in Nature
The growth of our services
Services Activity
Genetic Consultations
Metropolitan 7912
Regional 2168
Tasmania 316
Metabolic Consultations
Outpatient 1257
Inpatient 575
Laboratory Test
New Born Screening 71,866 babies
Maternal Serum screening 75 per cent of all pregnancies
Molecular tests 3919
Cytogenetics 12,333
Metabolic 5298 amino acid tests Chromosome
Director
Professor Agnes Bankier
Executive Assistant to Director
Alison van Bree
GENETIC HEALTH SERVICES
VICTORIA
Genetic Health Services Victoria Board
Chair, Professor Terry Dwyer AO MD
MPH
Professor Agnes Bankier
Professor Graeme Barnes
Mr Laurence G Cox
AO
Mr W H Hodgson
Professor Stephen Holdsworth
Professor Finlay Macrae
Clinical Geneticists
Dr David Amor
Professor Agnes Bankier
A/Professor Martin
Delatycki
Dr Heidi Peters
Dr Joy Yapilto-Lee
Clinical Genetics
Fellows
Dr Nicholas Pachter
Dr Tiong Yang Tan
Dr David Coman
Metabolic Fellows
Dr Alison Cozens
POSSUM Project
Professor Agnes Bankier
Dr Catherine Rose
Michael Black
Anne Cronin
Principal Genetic Counsellor/ Privacy
Dr Samantha Wake
Clinical Services
Coordinator
Robin Forbes
Genetic Counsellors
Lisette Curnow
Susan Fawcett
Dr Clara Gaff
Lisa Gordon
Ivan Macciocca
Margaret Ross
Michelle Sproule
Helen Upton
Jane Wallace
A/Professor Mac Gardner
Dr Marion Harris
Dr Peter Kannu
Dr George McGillivray
Dr Heidi Peters
Dr John Rogers
A/Professor Ravi
Savarirayan
A/Professor Les Sheffield
Dr Sue White
Professor Ingrid Winship
Metabolic
Physicians
Dr Avihu Boneh
Social Workers
Flora Pearce
Ross Tassicker
Metabolic
Dieticians
Maureen Humphrey
Jemma Watkins
Metabolic Nurse
Helen Upton
Laboratory Quality Assurance Officer
Anne Robertson
Education Project Officer
Dr Wiji Nadesapillai
Clinical Administration
Manager
David Blake
Clinical Administrative Assistants
Kim Cunningham
Debbie Davis
Sharon Grosvenor
Sue Hilton
Liz Kanellos
Katherine MacDonald
Maureen Ralph
James Shaw
Lucy Shaw
Helen Smith
Nikki Weekes
Associate Genetic Counsellors
Tarli Bogtstra
Michael Bogwitz
Sophie Devery
Renee Dow
Robin Forbes
Nikki Gelfand
Jacqueline Greenberg
Linda Hodgkin
Vicki Petrou
Katherine
Ruivenkamp
Alison Thornton
Senior Social
Worker
Margaret Sahhar
Section Leaders
Trent Burgess
David Francis
Fiona Norris
Administration
Fiona Keltie
Rebecca Manser
Emma Payne
Scientists
Alley Arvaj
Boys Amber
Antonia Chiappi
Essra Bartlett
Ian Brooks
Damien Bruno
Kathy Butler
Jackie Challis
Selga Cirulis
Sam Connors
Sylvea Corrie
Michael Cronin
Wali Drummond
Wendy Francis
Olivia Giouzeppos
Lily Gowans
Julie Hammer
Dr Tie Lan Han
Louise Hills
Helen Jackson
Dr Prabhakara
Krishnamurthy
Phung La
Paula Lall
Con Ngo
Xuon Nguyen Dao
Sara Nouri
Ralph Oertel
Maria Zarkadoulas
Receptionist
Vicki Hirt
VCGS
PATHOLOGY
CYTOGNETICS
LABORATORY
Head
A/Professor Howard
Slater
Deputy Head
Mark Pertile
Dr Priya Padman
Vida Petrovic
Lynda Phillips
Laboratory
Technicians
Julie Brown
Jolanta Karpowicz
Bronwyn Kenney
Holly Loncaric
Anna Rymer
Students
Damien Bruno
Ouda Khammy
Dr Mamoud
Khaniani
James McGhie Nurwahyuna Rosli
NEWBORN SCREENING LABORATORY
Head
Dr James Pitt
Section Leaders
Ivan Francis
Nick Tzanakos
Scientists
Manal Ibrahim
Thanh Nguyen
Lan Trieu
Linda Wilson
Laboratory
Technician
Jo Karlecik
MATERNAL SERUM SCREENING LABORATORY
Head
Ivan Francis (Programming)
Leonard Bonacquisto (Laboratory)
Administration
Deborah Dalton
Sara Grant
Yssa Reyes
Scientists
Stephen Dobie
Vivienne Iaschi
Vicki Katsonis
Gregoria Luna
Laboratory
Technicians
Ian Burns
Marina
Nakonechnaya
Monique Te-Haara
Laboratory
Assistants
Jacquie Como
Helen Hunter
Rina Marinucci
Patricia Snell
METABOLIC SCREENING LABORATORY
Head
Dr James Pitt
Section Leader
Mary Eggington
Scientists
Avantika Mishra
Michiel van Werkhoven
MOLECULAR GENETICS
LABORATORY
Head
Dr Desirée du Sart
Senior Scientists
Dr Belinda Chong
Steven Nasioulas
Melanie Smith
Administration
Fiona Keltie
Scientists
Andrew Bjorksten
Vanessa Calabro
Shannon Cowie
Nicole Gardiner
Justin Hassel
Maria Kaps
Sarah Pantaleo
Dean Phelan
Anna Richie
Laboratory
Technicians
Angela De Marco
Karina Sandoval
Students
Justin Hassel
Jan Riley
GENETIC
SUPPORT
NETWORK
VICTORIA
Leah Lonsdale
Catherine McLean
Abbott WGH, Winship IM, Gane EJ, Finau SA, Munn SR and Tukuitonga CF. Genetic diversity and linkage disequilibrium in the Polynesian population of Niue Island. Human Biology 78: 131–145 (2006)
Abdullah AF and Menahem S. Transcatheter closure of dilated left superior vena cava for resolution of late cyanosis following fontan palliation. Heart, Lung & Circulation 15: 393–396 (2006)
Ades LC, Sullivan K, Biggin A, Haan EA, Brett M, Holman KJ, Dixon J, Robertson S, Holmes AD, Rogers J and Bennetts B. FBN1, TGFBR1, and the Marfan-craniosynostosis/mental retardation disorders revisited. American Journal of Medical Genetics Part A 140: 1047–1058 (2006)
Agarwal AK, Zhou XJ, Hall RK, Nicholls K, Bankier A, Van Esch H, Fryns JP and Garg A. Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency. Journal of Investigative Medicine 54: 208–213 (2006)
Aghmesheh M, Suo Z, Friedlander M, Nesland JM, Kaern J, Stewart M, KconFab Investigators, Dorum A, Tucker KM and Buckley MF. Chromosome 2q24.2 is lost in sporadic but not in BRCA1-associated ovarian carcinomas. Pathology 38: 145–151 (2006)
Ahluwalia J, Tooley J, Cheema I, Sweet DG, Curley AE, Halliday HL, Field D, Al’Malik H, Annamalai S, Midgley P, Hardy P, Tomlin K and Elbourne D. A dose response study of inhaled nitric oxide in hypoxic respiratory failure in preterm infants. Early Human Development 82: 477–483 (2006)
Alex G, Catto-Smith AG, Ditchfield M, Roseby R, Robinson PJ, Cameron FJ and Oliver MR. Is significant cystic fibrosis related liver disease a risk factor in the development of bone mineralization abnormalities? Pediatric Pulmonology 41: 338–344 (2006)
Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, Owens RT, Sasaki T, Timpl R and Fitzgerald J. WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. Journal of Biological Chemistry 281: 7341–7349 (2006)
Allen KJ and Buck NE. Clinical application of hepatocyte transplantation: What are the current limitations? Current Opinion in Organ Transplantation 11: 648–653 (2006)
Allen KJ, Buck NE, Cheah DM, Gazeas S, Bhathal P and Mercer JF. Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading. Biometals 19: 555–564 (2006)
Allen KJ, Hill DJ and Heine RG. Food allergy in childhood. Medical Journal of Australia 185: 394–400 (2006)
Alsop K, Mead L, Smith LD, Royce SG, Tesoriero AA, Young JP, Haydon A, Grubb G, Giles GG, Jenkins MA, Hopper JL and Southey MC. Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years. European Journal of Cancer 42: 1357–1361 (2006)
Ambler GR, Fairchild J, Craig ME and Cameron FJ. Contemporary Australian outcomes in childhood and adolescent type 1 diabetes: 10 years post the Diabetes Control and Complications Trial. Journal of Paediatrics & Child Health 42: 403–410 (2006)
Ameratunga S, Macmillan A, Stewart J, Scott D, Mulholland K and Crengle S. Meningococcal Management Team. Evaluating the post-licensure effectiveness of a group B meningococcal vaccine in New Zealand: amulti-faceted strategy. Vaccine 23: 2231–2234 (2006)
Amor DJ, Neo WT, Waters E, Heussler H, Pertile M and Halliday J. Health and developmental outcome of children following prenatal diagnosis of confined placental mosaicism. Prenatal Diagnosis 26: 443–448 (2006)
Anderson BJ and Palmer GM. Recent developments in the pharmacological management of pain in children. Current Opinion in Anaesthesiology 19: 285–292 (2006)
Anderson BJ and Palmer GM. Recent pharmacological advances in paediatric analgesics. Biomedicine & Pharmacotherapy 60: 303–309 (2006)
Anderson DP, Harvey AS, Saling MM, Anderson V, Kean M, Abbott DF, Wellard RM and Jackson GD. fMRI lateralization of expressive language in children with cerebral lesions. Epilepsia 47: 998–1008 (2006)
Anderson PJ and Doyle LW. Neurodevelopmental outcome of bronchopulmonary dysplasia. Seminars in Perinatology 30: 227–232 (2006)
Anderson V, Anderson D and Anderson P. Comparing attentional skills in children with acquired and developmental central nervous system disorders. Journal of the International Neuropsychological Society 12: 519–531 (2006)
Anderson V, Catroppa C. Advances in postacute rehabilitation after childhood-acquired brain injury: a focus on cognitive, behavioral, and social domains. American Journal of Physical Medicine & Rehabilitation 85: 9 767–778 (Sep 2006)
Anderson VA, Catroppa C, Dudgeon P, Morse SA, Haritou F and Rosenfeld JV. Understanding predictors of functional recovery and outcome 30 months following early childhood head injury. Neuropsychology 20: 42–57 (2006)
Andreasyan K, Ponsonby AL, Dwyer T, Morley R, Riley M, Dear K and Cochrane J. Higher maternal dietary protein intake in late pregnancy is associated with a lower infant ponderal index at birth (advanced online publication). European Journal of Cardio-Thoracic Surgery (2006)
Apicella C, Peacock SJ, Andrews L, Tucker K, Bankier A, Daly MB and Hopper JL. Determinants of preferences for genetic counselling in Jewish women. Familial Cancer 5: 159–167 (2006)
Armstrong KL, Henderson C, Hoan NT and Warne GL. Living with congenital adrenal hyperplasia in Vietnam: A survey of parents Journal of Pediatric Endocrinology & Metabolism 19: 1207–1223 (2006)
Arsov T, Silva DG, O’Bryan MK, Sainsbury A, Lee NJ, Kennedy C, Manji SSM, Nelms K, Liu CN, Vinuesa CG and de Kretser DM. Fat Aussie — A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Molecular Endocrinology 20: 1610–1622 (2006)
Asher MI, Montefort S, Bjorksten B, Lai CKW, Strachan DP, Weiland SK, Williams H and Isaac Phase Three Study Group (Robertson C). Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368: 733–743 (2006)
Augustin SL, Horton S, Thuys C, Bennett M, Claessen C and Brizard C. The use of extracorporeal life support in the treatment of influenze associated myostitis/rhabdomyolysis. Perfusion 21: 121–125 (2006)
Auto J, Nasi T, Ogaoga D, Kelly J and Duke T. Hospital services for children in the Solomon Islands: Rebuilding after the civil conflict. Journal of Paediatrics & Child Health 42: 680–687 (2006)
Babl F, Borland M, Ngo P, Acworth J, Krieser D, Pandit S, Pitt WR, Cotterell E and Jamison S. Paediatric Research in Emergency Departments International Collaborative (PREDICT): First steps towards the development of an Australian & New Zealand research network. Emergency Medicine Australasia 18: 143–147 (2006)
Babl F, Priestley S, Krieser D, Miller J, Tully M, Spicer M, McGowan V and Dilla N. Development and implementation of an education and credentialing programme to provide safe paediatric procedural sedation in emergency departments. Emergency Medicine Australasia 18: 489–497 (2006)
Babl FE, Jamison SR, Spicer M and Bernard S. Toxicology inhaled methoxyflurane as a prehospital analgesic in children Emergency Medicine Australasia 18: 404–410 (2006)
Babl FE, Lewena S and Brown L. Vaccination related adverse events. Pediatric Emergency Care 22: 514–519 (2006)
Bajpai A and Menon PSN. Insulin like Growth Factors Axis and Growth Disorders. Indian Journal of Pediatrics 73: 67–71 (January 2006)
Bajpai A, Kabra M and Menon PSN. Combination Growth hormone and gonadotropin releasing hormone analog therapy in 11 beta-hydroxylase deficiency. Journal of Pediatric Endocrinology & Metabolism 19: 855–857 (2006)
Bajpai A, Kabra M, Gupta AK and Menon PSN. Growth pattern and skeletal maturation following growth hormone therapy in growth hormone deficiency: Factors influencing outcome. Indian Pediatrics 43: 593–599 (2006)
Baker R. Gait analysis methods in rehabilitation. Journal of Neuroengineering and Rehabilitation. 3: 4 (2006)
Ball C and Westhorpe RN. Muscle relaxants — pancuronium and vecuronium. Anaesthesia and Intensive Care 34: 137 (2006)
Ball C and Westhorpe RN. Muscle relaxants — reversal agents. Anaesthesia and Intensive Care 34: 415 (2006)
Ball C and Westhorpe RN. Muscle relaxants — suxamethonium and THA. Anaesthesia and Intensive Care 34: 3 (2006)
Balleine RL, Murali R, Bilous AM, Farshid G, Waring P, Provan P, Byth K, Thorne H, KconFab Investigators and Kirk JA. Histopathological features of breast cancer in carriers of ATM gene variants. Histopathology 49: 523–532 (2006)
Bamberg J, Findley S and Toumbourou JW. The BEST plus approach to assisting families recover from youth substance problems. Youth Studies Australia 25: 25–32 (2006)
Barnes C and Deveber G. Prothrombotic abnormalities in childhood ischaemic stroke. Thrombosis Research 118: 67–74 (2006)
Barnett P. Pals pediatric advanced life support. Journal of Paediatrics & Child Health 42: 398–399 (2006)
Bar-Zeev N and Buttery JP. Combination conjugate vaccines. Expert Opinion on Drug Safety 5: 351–360 (2006)
Bayer JK, Hiscock H, Hampton A and Wake M. Sleep problems in young infants and maternal mental and physical health. Journal of Paediatrics & Child Health 43: 66–73 (2006)
Bayer JK, Hiscock H, Morton-Allen E, Ukoumunne OC and Wake M. Prevention of mental health problems: rationale for a universal approach. Archives of Disease in Childhood 92: 34–38 (2006)
Bayer JK, Sanson AV and Hemphill SA. Children’s moods, fears and worries: Development of an early childhood parent questionnaire. Journal of Emotional and Behavioral Disorders 14: 41–49 (2006)
Bayer JK, Sanson AV and Hemphill SA. Parent influences on early childhood internalizing difficulties. Journal of Applied Developmental Psychology 27: 542–559 (2006)
Begg CB, Hummer AJ, Mujumdar U, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Culver HA, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Busam K, From L, Berwick M and GEM Study Group. A design for cancer case control studies using only incident cases: experience with the GEM study of melanoma. International Journal of Epidemiology 35: 756–764 (2006)
Bell RJ, Donath S, Davison SL and Davis SR. Endogenous androgen levels and wellbeing: differences between pre and postmenopausal women. Menopause: The Journal of the North American Menopause Society 13:1 65–71 (2006)
Bellgrove MA, Chambers CD, Vance A, Hall N, Karamitsios M and Bradshaw, JL. Lateralized deficit of response inhibition in early onset schizophrenia. Psychological Medicine 36: 495–505 (2006)
Belluoccio D, Wilson R, Thornton DJ, Wallis TP, Gorman JJ and Bateman JF. Proteomic analysis of mouse growth plate cartilage. Proteomics 6: 6549–6553 (2006)
Ben-Meir D, McMullin N, Kimber C, Gibikote S, Kongola K and Hutson JM. Reimplantation of obstructive megaureters with and without tailoring. Journal of Pediatric Urology 2: 178–181 (2006)
Berkovic SF, Harkin L, McMahon JM, Pelekanos T, Zuberi SM, Wirrell EC, Gill DS, Iona X, Mulley JC and Scheffer IE. De novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: A retrospective study. Lancet Neurology 5: 488–492 (2006)
Berwick M, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Busam K, From L, Mujumdar U, Wilcox H, Begg CB and GEM Study Group. The prevalence of CDKN2A germ line mutations and relative risk for cutaneous malignant melanoma: An international population based study. Cancer Epidemiology, Biomarkers and Prevention. 15: 1520–1525 (2006)
Betts J, Mckay J, Maruff P and Anderson V. The development of sustained attention in children: The effect of age and task load. Child Neuropsychology 12: 205–221 (2006)
Bialocerkowski AE and Galea M. Comparison of visual and objective quantification of elbow and shoulder movement in children with obstetric brachial plexus palsy. Journal of Brachial Plexus and Peripheral Nerve Injury 1: 5– (2006)
Bines J. Intussusception and rotavirus vaccines. Vaccine 24: 3772–3776 (2006)
Bines JE, Liem NT, Justice F, Son TN, Carlin JB, de Campo M, Jamsen K, Mulholland K, Barnett P and Barnes GL. Validation of clinical case definition of acute infussusception in infants in Viet Nam and Australia. Bulletin of the World Health Organization 7: 569–575 (2006)
Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, Barnett P, Bishop RF, Robins-Browne R, Carlin JB and Intussusception Study Group. Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus. Journal of Pediatrics 149: 452–460 (2006)
Blake WE, Chow CW, Holmes AD and Meara JG. Nasal dermoid sinus cysts: a retrospective review and discussion of investigation and management. Annals of Plastic Surgery 57: 535–540 (2006)
Block SL, Nolan T, Sattler C, Barr E, Giacoletti KED, Marchant CD, Castellsague X, Rusche SA, Lukac S, Bryan JT, Cavanaugh PF, Reisinger KS and Protocol 016 Study Group. Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus like particle vaccine in male and female adolescents and young adult women. Pediatrics 118: 2135–2145 (2006)
Bolton CM, Myles PS, Nolan T and Sterne JA. Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: A systematic review and meta analysis. British Journal of Anaesthesia 97: 593–604 (2006)
Bond L, Clements J, Bertalli N, Evans-Whipp T, McMorris BJ, Patton GC, Toumbourou JW and Catalano RF. A comparison of self reported puberty using the pubertal development scale and the sexual maturation scale in a school based epidemiologic survey. Journal of Adolescence 29: 709–720 (2006)
Boneh A, Andresen BS, Gregersen N, Ibrahim M, Tzanakos N, Peters H, Yaplito-Lee J and Pitt JJ. VLCAD deficiency: pitfalls in newborn screening and confirmation of diagnosis by mutation analysis. Molecular Genetics and Metabolism 88: 166–170 (2006)
Boneh A, Francis DEM, Humphrey M, Upton HJ and Peters, HL. Three year audit of the hyperphenylalaninaemia/ phenylketonuria spectrum in Victoria. Journal of Paediatrics & Child Health 42: 496–498 (2006)
Boneh A. Regulation of mitochondrial oxidative phosphorylation by second messenger-mediated signal transduction mechanisms. CMLS — Cellular and Molecular Life Sciences 63: 1236–1248 (2006)
Borschmann ME and Berkowitz RG. Oneoff streptococcal serologic testing in young children with recurrent tonsillitis. Annals of Otology Rhinology and Laryngology 115: 357–360 (2006)
Boyle RJ and Tang ML. Can allergic diseases be prevented prenatally? Allergy 61: 1423–1431 (2006)
Boyle RJ and Tang ML. The role of probiotics in the management of allergic disease. Clinical and Experimental Allergy 36: 568–576 (2006)
Boyle RJ, Le C, Balloch A and Tang ML. The clinical syndrome of specific antibody deficiency in children. Clinical and Experimental Immunology 146: 486–492 (2006)
Boyle RJ, Robins-Browne RM and Tang ML. Probiotic use in clinical practice: What are the risks? American Journal of Clinical Nutrition 83: 1256–1264 (2006)
Bradshaw JM, Saling M, Anderson V, Hopwood M, and Brodtmann A. Higher cortical deficits influence attentional processing in dementia with Lewy bodies, relative to patients with dementia of the Alzheimer’s type and controls. Journal of Neuorology Neurosurgery and Psychiatry 77: 1129–1135 (2006)
Briellmann RS, Little T, Harvey AS, Abbott DF, Jacobs R, Waites AB and Jackson GD. Pathologic and physiologic function in the subcortical band of double cortex. Neurology 67: 1090–1093 (2006)
Briellmann RS, Labate A, Harvey AS, Saling MM, Sveller C, Lillywhite L, Abbott DF and Jackson GD. Is language lateralization in temporal lobe epilepsy patients related to the nature of the epileptogenic lesion? Epilepsia 47: 916–920 (2006)
Brizard C. Surgical repair of infundibular ventricular septal defect and aortic regurgitation. Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual 153–160 (2006)
Brown JJ and Warne, GL. Growth in precocious puberty. Indian Journal of Pediatrics 73: 81–88 (2006)
Brown NC, Doyle LW, Bear MJ and Inder TE. Alterations in neurobehavior at term reflect differing perinatal exposures in very preterm infants. Pediatrics 118: 2461–2471 (2006)
Brown RC, Dwyer T, Kasten C, Krotoski D, Linet MS, Olsen J, Scheidt P and Winn DM. The international childhood cancer cohort consortium. Birth Defects Research Part A — Clinical and Molecular Teratology 2006: 371–371 (2006)
Bruinsma FJ, Venn AJ, Patton GC, Rayner JA, Pyett P, Werther G, Jones P and Lumley JM. Concern about tall stature during adolescence and depression in later life. Journal of Affective Disorders 91: 145–152 (2006)
Bruno DL, Burgess T, Ren H, Nouri S, Pertile MD, Francis DI, Norris F, Kenney BK, Schouten J, Choo KHA and Slater HR. High throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with an ancillary FISH test for polyploidy. American Journal of Medical Genetics Part A 140: 2786–2793 (2006)
Bryar T. Public space and violence in young people experiencing homelessness. Parity 90–91 (2006)
Cahill H. Preventing drug-related harm. Dept Education Science & Training Guide, Canberra (2006)
Cameron F. Teenagers with diabetes management challenges. Australian Family Physician 35: 386–390 (2006)
Cameron FJ and Brown J. Thyroid Disorders In Childhood And Adolescence. In: Roberton D and Robinson M (eds). Practical Paediatrics. Chuchill Livingstone (2006)
Campbell MW, Williams J, Hampton A and Wake M. Maternal concern and perceptions of overweight in Australian preschool aged children. Medical Journal of Australia 184: 274–277 (2006)
Carpentier A and Brizard C. Congenital malformation of the mitral valve in surgery for congenital heart defects. John Willey and Sons UK (2006)
Carpentier A and Brizard C. Malformations of the tricuspid valve and Ebstein’s anomaly in surgery for congenital heart defects. John Willey and Sons UK (2006)
Catroppa C and Anderson V. Planning, problem solving and organizational abilities in children following traumatic brain injury: Intervention techniques. Pediatric Rehabilitation 9: 89–97 (2006)
Catroppa C, Anderson VA, Morse SA, Haritou F and Rosenfeld JV. Children’s attentional skills 5 years post-TBI (advanced online publication). Journal of Pediatric Psychology (2006)
Catto-Smith AG and Jimenez S. Morbidity and mortality after percutaneous endoscopic gastrostomy in children with neurological disability. Journal of Gastroenterology and Hepatology 21: 734–738 (2006)
Catto-Smith AG, Trajanovska M and Taylor RG. Long term continence in patients with Hirschsprung’s disease and Down syndrome. Journal of Gastroenterology and Hepatology 21: 748–753 (2006)
Chalkiadis GA and Anderson BJ. Age and size are the major covariates for prediction of levobupivacaine clearance in children. Paediatric Anaesthesia 16: 275–282 (2006)
Chan, B, Zacharin, M. Pamidronate treatment of polyostotic fibrous dysplasia: Failure to prevent expansion of dysplastic lesions during childhood. Journal of Pediatric Endocrinology & Metabolism 19: 75–80 (2006)
Chang AB, Landau LI, Van Asperen PP, Glasgow NJ, Robertson CF, Marchant JM and Mellis CM. Cough in children: Definitions and clinical evaluation. Medical Journal of Australia 184: 398–403 (2006)
Chauhan A, Rockel S, Farlie P and Meara JG. Tissue engineering of bone using a chick chorio allantoic membrane graft model: PR039. Australian & New Zealand Journal of Surgery 76 (suppl1): A65 (2006)
Cheah DM, Deal YJ, Wright PF, Buck NE, Chow CW, Mercer JF and Allen KJ. Heterozygous tx mice have an increased sensitivity to copper loading: Implications for Wilson’s disease carriers (advanced online publication). Biometals (2006)
Chenevix-Trench G, Healey S, Lakhani S, Waring P, Cummings M, Brinkworth R, Deffenbaugh AM, Burbidge LA, Pruss D, Judkins T, KconFab Investigators and others. Genetic and histopathologic evaluation of BRCA1 and BRCA2 DNA sequence variants of unknown clinical significance. Cancer Research 66: 2019–2027 (2006)
Chew C, Stone S, Donath SM and Penny DJ. Impact of antenatal screening on the presentation of infants with congenital heart disease to a cardiology unit. Journal of Paediatrics & Child Health 42: 704–708 (2006)
Chow E, Lipton L, Lynch E, D’Souza R, Aragona C, Hodgkin L, Brown G, Winship I, Barker M, Buchanan D, Cowie S, Nasioulas S, Du Sart D, Young J, Leggett B, Jass J and Macrae F. Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH. Gastroenterology 131: 30–39 (2006)
Cincotta DR, Crawford NW, Lim A, Cranswick NE, Skull S, South M and Powell CV. Comparison of complementary and alternative medicine use: reasons and motivations between two tertiary children’s hospitals. Archives of Disease in Childhood 91: 153–158 (2006)
Cincotta NF, Tokatlian N and Miller J. The international exchange program: In the first person. Social Work in Health Care 43: 193–197 (2006)
Clarke NF, Kidson W, Quijano-Roy S, Estournet B, Ferreiro A, Guicheney P, Manson JI, Kornberg AJ and Shield LK. North KN SEPN1: Associated with congenital fiber type disproportion and insulin resistance. Annals of Neurology 59: 546–552 (2006)
Clay MA, Donovan C, Butler L and Oldenburg BF. The returns from cardiovascular research: The impact of the National Heart Foundation of Australia’s investment. Medical Journal of Australia 185: 209–212 (2006)
Coleman B, Hardman J, Coco A, Epp S, de Silva M, Crook J and Shepherd R. Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Cell Transplantation 15: 369–380 (2006)
Connell T, Bar-Zeev N and Curtis, N. Early detection of perinatal tuberculosis using a whole blood interferon-gamma release assay. Clinical Infectious Diseases 42: 0–0 (2006)
Connell TG, Curtis N, Ranganathan SC and Buttery JP. Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children. Thorax 61: 616–620 (2006)
Connell TG, Rangaka MX, Curtis N and Wilkinson RJ. QuantiFERON-TB Gold: State of the art for the diagnosis of tuberculosis infection? Expert Review of Molecular Diagnostics 6: 663–677 (2006)
Coombs CJ, Richardson PW, Dowling GJ, Johnstone BR and Monagle P. Brachial artery thrombosis in infants: An algorithm for limb salvage. Plastic and Reconstructive Surgery 117: 1481–1488 (2006)
Copnell B and Bruni N. Breaking the silence: Nurses’ understandings of change in clinical practice. Journal of Advanced Nursing 55: 301–309 (2006)
Copnell B. The knowledgeable practice of critical care nurses: A poststructural inquiry (advanced online publication). International Journal of Nursing Studies (2006)
Corben LA, Georgiou-Karistianis N, Fahey MC, Storey E, Churchyard A, Horne M, Bradshaw JL and Delatycki MB. Towards an understanding of cognitive function in Friedreich ataxia. Brain Research Bulletin 70: 197–202 (2006)
Craig GM, Carr LJ, Cass H, Hastings RP, Lawson M, Reilly S, Townsend J and Spitz L. Medical, surgical and health outcomes of gastrostomy feeding. Developmental Medicine & Child Neurology 48: 353–360 (2006)
Critchley C and Sanson A. Is parent disciplinary behaviour enduring or situational? A multilevel modeling investigation of individual and contextual influences on power assertive and inductive reasoning behaviours. Journal of Applied Developmental Psychology 27: 370–388 (2006)
Crossland DS, Anderson RH and Wilkinson JL. Concordant ventriculoarterial connections with parallel arterial trunks in the setting of isomerism of the right atrial appendages. Pediatric Cardiology 27: 511–514 (2006)
Crowther CA, Haslam RR, Hiller JE, Doyle LW and Robinson JS. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: A randomised controlled trial. Lancet 367: 1913–1919 (2006)
Curtis, N. Viral haemorrhagic fevers caused by Lassa, Ebola and Marburg viruses. Advances in Experimental Medicine & Biology 582: 35–44 (2006)
Da Costa AC, Walters I, Savarirayan R, Anderson VA, Wrennall JA and Meara JG. Intellectual outcomes in children and adolescents with syndromic and nonsyndromic craniosynostosis. Plastic and Reconstructive Surgery 118: 175–181 (2006)
Dahl HH, Tobin SE, Poulakis Z, Rickards FW, Xu X, Gillam L, Williams J, Saunders K, Cone-Wesson B and Wake M. The contribution of GJB2 mutations to slight or mild hearing loss in Australian elementary school children. Journal of Medical Genetics 43: 850–855 (2006)
Dargaville PA, Copnell B and Australian New Zealand Neonatal Network. The epidemiology of meconium aspiration syndrome: Incidence, risk factors, therapies, and outcome Pediatrics 117: 1712–1721 (2006)
Davidson AJ, Ironfield CM, Skinner AV and Frawley GP. The effects of caudal local anesthesia blockade on the bispectral index during general anesthesia in children. Paediatric Anaesthesia 16: 828–833 (2006)
Davidson AJ, Shrivastava PP, Jamsen K, Huang GH, Czarnecki C, Gibson MA, Stewart SA and Stargatt R. Risk factors for anxiety at induction of anesthesia in children: A prospective cohort study. Paediatric Anaesthesia 16: 919–927 (2006)
Davidson AJ. Measuring anesthesia in children using the EEG. Paediatric Anaesthesia 16: 374–387 (2006)
Davies B, d’Udekem Y and Brizard CP. Cyanoacrylate adhesive coating for the treatment of serous leaks from modified Blalock-Taussig Gore-Tex shunts. Annals of Thoracic Surgery 82: 1922–1923 (2006)
Davis E, Waters E, Mackinnon A, Reddihough D, Graham HK, Mehmet-Radji O and Boyd R. Paediatric quality of life instruments: A review of the impact of the conceptual framework on outcomes. Developmental Medicine & Child Neurology 48: 311–318 (2006)
Davis PG and Morley CJ. Volume control: A logical solution to volutrauma. Journal of Pediatrics 149: 290–291 (2006)
Davis SR, Goldstat R, Papalia M-A, Shah S, Kulkarni J, Donath S and Bell RJ. Effects of aromatase inhibition on sexual function and wellbeing in postmenopausal women treated with testosterone: a randomized placebo controlled trial. Menopause: The Journal of the North American Menopause Society 13:1 37–45 (2006)
Dawson JA, Davis PG, O’Donnell CP, Kamlin CO and Morley CJ. Free flow oxygen delivery to newly born infants (advanced online publication). Archives of Disease in Childhood — Fetal & Neonatal Edition (2006)
de Amorim e Silva CJT, Mackenzie A, Hallowell LM, Stewart SE and Ditchfield MR. Practice MRI: Reducing the need for sedation and general anaesthesia in children undergoing MRI. Australasian Radiology 50: 319–323 (2006)
De Silva MG, Hildebrand MS, Christopoulos H, Newman MR, Bell K, Ritchie M, Smyth GK and Dahl HH. Gene expression changes during step wise differentiation of embryonic stem cells along the inner ear hair cell pathway. ACTA OtoLaryngologica 126: 1148–1157 (2006)
Dobson F, Morris ME, Baker R and Graham HK. Gait classification in children with cerebral palsy: A systematic review. Gait & Posture 25: 140–152 (2006)
Dobson F, Morris ME, Baker R, Wolfe R and Graham HK. Clinician agreement on gait pattern ratings in children with spastic hemiplegia. Developmental Medicine & Child Neurology 48: 429–435 (2006)
Downer SR, Meara JG, Da Costa AC and Sethuraman K. SMS text messaging improves outpatient attendance. Australian Health Review 30: 389–396 (2006)
Doyle L and Colletti JE. Pediatric procedural sedation and analgesia. Pediatric Clinics of North America 53: 279–292 (2006)
Doyle LW and Victorian Infant Collaborative Study. Respiratory function at age 8–9 years in extremely low birthweight/very preterm children born in Victoria in 1991–1992. Pediatric Pulmonology 41: 570–576 (2006)
Doyle LW, Davis PG, Morley CJ, McPhee A, Carlin JB and DART Study Investigators. Low dose dexamethasone facilitates extubation among chronically ventilator-dependent infants: A multicenter, international, randomized, controlled trial. Pediatrics 117: 75–83 (2006)
Doyle LW, Faber B, Callanan C, Freezer N, Ford GW and Davis NM. Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescence. Pediatrics 118: 10–113 (2006)
Doyle LW. Evaluation of neonatal intensive care for extremely low birth weight infants. Seminars In Fetal & Neonatal Medicine 11: 139–145 (2006)
Doyle LW. The burden of illness in perinatal and neonatal care: The epidemiologist’s role. Seminars In Fetal & Neonatal Medicine 11: 69–72 (2006)
Duke G, Santamaria J, Shann F and Stow R. Outcome based clincial indicators for intensive care medicine. Anaesthesia & Intensive Care 33: 303–310 (2006)
Duke T, Keshishiyan E, Kuttumuratova A, Ostergren M, Ryumina I, Stasii E, Weber MW and Tamburlini G. Quality of hospital care for children in Kazakhstan, Republic of Moldova, and Russia: systematic observational assessment. Lancet 9514: 925 (2006)
Dunbar M, Moberley S, Nelson S, Leach A and Andrews R. Clear not simple: An approach to community consultation for a maternal pneumococcal vaccine trial among Indigenous women in the Northern Territory of Australia (advanced online publication). Vaccine (2006)
Duncan RE and Delatycki MB. Predictive genetic testing in young people for adult-onset conditions: Where is the empirical evidence? Clinical Genetics 69: 8–16 (2006)
Duncan RE, Foddy B and Delatycki MB. Refusing to provide a prenatal test: can it ever be ethical? British Medical Journal 333: 1066–1068 (2006)
Dunn KL, Moulden A, McDougall P and Bowes G. Patient safety: A view from Down Under. Pediatric Clinics of North America 53: 1217–1230 (2006)
Dwyer T, Hosmer D, Hosmer T, Venn AJ, Blizzard CL, Granger RH, Cochrane JA, Blair SN, Shaw JE, Zimmet PZ and Dunstan D. The inverse relationship between number of steps per day and obesity in a population based sample — the AusDiab study (advanced online publication). International Journal of Obesity (2006)
Ejeskar K, Fransson S, Zaibak F and Ioannou PA. Method for efficient transfection of in vitro-transcribed mRNA into SKN-AS and HEK293 cells: Difference in the toxicity of nuclear EGFP compared to cytoplasmic EGFP. International Journal of Molecular Medicine 17: 1011–1016 (2006)
Ekert H, Brizard C, Eyers R, Cochrane A and Henning R. Elective administration in infants of low dose recombinant activated factor VII (rFVIIa) in cardiopulmonary bypass surgery for congenital heart disease does not shorten time to chest closure or reduce blood loss and need for transfusions: A randomized, double blind, parallel group, placebo controlled study of rFVIIa and standard haemostatic replacement therapy versus standard haemostatic replacement therapy. Blood Coagulation & Fibrinolysis 17: 389–395 (2006)
Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C and Vaux DL. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood 108: 1461–1468 (2006)
Embry Flory JJ, Fosang AJ and Knudson W. The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan. Arthritis & Rheumatism 54: 443–454 (2006)
Fahey MC, Corben L, Collins V, Churchyard AJ and Delatycki MB. How is disease progress in Friedreich ataxia best measured? A study of four rating scales (dvanced online publication). Journal of Neurology, Neurosurgery & Psychiatry (2006)
Farrant B and Sawyer SM. Sexual and reproductive health in adolescents with CF: Hard to talk about but too important to ignore (p177–191). In: Balen R and Crawshaw M (eds). Sexuality & Fertility in Ill Health & Disability from Early Adolescence to Adulthood (2006)
Farrant B and Sawyer SM. Sexuality in young people with Neurogenic Bladder Dysfunction (p317–323). In: Esposito C, Guys JM, Gough D and Savanelli A (eds). Pediatric Neurogenic Bladder Dysfunction: Diagnosis, Treatment, Long-Term Follow-up. Springer (2006)
Farshid G, Balleine RL, Cummings M, Waring P and KconFab Investigators. Morphology of breast cancer as a means of triage of patients for BRCA1 genetic testing. American Journal of Surgical Pathology 30: 1357–1366 (2006)
Ferec C, Casals T, Chuzhanova N, Macek M, Bienvenu T, Holubova A, King C, McDevitt T, Castellani C, Farrell PM, Sheridan M, Pantaleo SJ, Loumi O, Messaoud T, Cuppens H, Torricelli F, Cutting GR, Williamson R, Ramos MJA, Pignatti PF, Raguenes O, Cooper DN, Audrezet MP and Chen JM. Gross genomic rearrangements involving deletions in the CFTR gene: Characterization of six new events from a large cohort of hitherto unidentified cystic fibrosis chromosomes and meta analysis of the underlying mechanisms. European Journal of Human Genetics 14: 567–576 (2006)
Ferreira MA, O’Gorman L, Le Souef P, Burton PR, Toelle BG, Robertson CF, Martin NG and Duffy DL. Variance components analyses of multiple asthma traits in a large sample of Australian families ascertained through a twin proband. Allergy 61: 245–253 (2006)
Fiander M, Burns T, Ukoumunne OC, Fahy T, Creed F, Tyrer P and Byford S. Do care patterns change over time in a newly established mental health service? A report from the UK700 trial. European Psychiatry 21: 300–306 (2006)
Fielding J, Georgiou-Karistianis N, Millist L, Fahey M and White O. Saccadic trajectory in Huntington’s disease Journal of the International Neuropsychological Society 12: 455–464 (2006)
Filan PM, Inder TE, Cameron FJ, Kean MJ and Hunt, RW. Neonatal hypoglycemia and occipital cerebral injury. Journal of Pediatrics 148: 552–555 (2006)
Filan PM, McDougall PN and Shekerdemian, LS. Combination pharmacotherapy for severe neonatal pulmonary hypertension. Journal of Paediatrics & Child Health 42: 219–220 (2006)
Fitzgerald LM, Fryer JL, Dwyer T and Humphrey SM. Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH on melanin synthesis in humans with MC1R variant alleles. Peptides 27: 388–394 (2006)
Foddy B and Savulescu J. Addiction and autonomy: Can addicted people consent to the prescription of their drug of addiction? Bioethics 20: 1–15 (2006)
Forbes E, Hulett M, Ahrens R, Wagner N, Smart V, Matthaei KL, Brandt EB, Dent LA, Rothenberg ME, Tang MLK, Foster PS and Hogan SP. ICAM-1 dependent pathways regulate colonic eosinophilic inflammation. Journal of Leukocyte Biology 80: 330–341 (2006)
Forzano F, Daubeney PEF and White SM. Midline raphe, sternal cleft and other midline abnormalities: A new dominant syndrome? American Journal of Medical Genetics Part A 135: 9– (2006)
Fosang A and Baker, R. A method for comparing manual muscle strength measurements with joint moments during walking. Gait & Posture 24: 406–411 (2006)
Frawley GP, Downie S and Huang GH. Levobupivacaine caudal anesthesia in children: A randomized double blind comparison with bupivacaine. Paediatric Anaesthesia 16: 754–760 (2006)
Fyfe S, Downs J, McIlroy O, Burford B, Lister J, Reilly S, Laurvick C, Philippe C, Msall M, Kaufmann WE, Ellaway C and Leonard H. Development of a video based evaluation tool in Rett Syndrome (advanced online publication). Autism & Development Disorders (2006)
Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun, LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D and Gilbertson RJ. Risk adapted craniospinal radiotherapy followed by high dose chemotherapy and stem cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): Long term results from a prospective, multicentre trial. Lancet Oncology 7: 813–820 (2006)
Galati JC, Harsley S, Richmond P and Carlin JB. The burden of rotavirus related illness among young children on the Australian health care system. Australian & New Zealand Journal of Public Health 30: 416–421 (2006)
Galbally M, Lewis A, Snellen M, Paul lC, Szego K and Trauer T. Mother infant psychotherapy and perinatal psychiatry: Current clinical practice and future directions. Australasian Psychiatry 14: 384–389 (2006)
Ganesalingam K, Sanson A, Anderson V and Yeates KO. Self egulation and social and behavioral functioning following childhood traumatic brain injury. Journal of the International Neuropsychological Society 12: 609–621 (2006)
Garland SM, Waddell R, Mindel A, Denham IM and McCloskey JC. An open label phase II pilot study investigating the optimal duration of imiquimod 5% cream for the treatment of external genital warts in women. International Journal of STD & AIDS 17: 448–452 (2006)
Gason AA, Delatycki MB, Metcalfe SA and Aitken M. It’s “back to school” for genetic screening. European Journal of Human Genetics 14: 384–389 (2006)
Geevasinga N, Richards F, Jones KJ and Ryan MM. Juvenile Huntington disease. Journal of Paediatrics & Child Health 42: 552–554 (2006)
Gerner B, McCallum Z, Sheehan J, Harris C and Wake M. Are general practitioners equipped to detect child overweight/ obesity? Survey and audit. Journal of Paediatrics & Child Health 42: 206–211 (2006)
Gillam L, Poulakis Z, Tobin S and Wake M. Enhancing the ethical conduct of genetic research: Investigating views of parents on including their healthy children in a study on mild hearing loss. Journal of Medical Ethics 32: 537–541 (2006)
Goldfeld S. Community paediatrics and children’s health: An idea whose time has come. Journal of Paediatrics & Child Health 42: 309–310 (2006)
Gozzi TG, Simm PJ and Cameron FJ. Spontaneous recovery of steroid-induced osteopenia. Journal of Paediatrics & Child Health 42: 68–69 (2006)
Graham J and Davidson AJ. Anaesthesia for major orthopaedic surgery in a child with an acute tracheobronchial injury. Anaesthesia & Intensive Care 34: 88–92 (2006)
Granger RH, Blizzard L, Fryer JL and Dwyer T. Association between dietary fat and skin cancer in an Australian population using case control and cohort study designs. BMC Cancer 6: 141 (2006)
Greaves R, Poomthavorn P, Zacharin M. 11 beta-hydroxylase deficiency masked by alternative medicines. Journal of Paediatrics & Child Health 42: 652–654 (2006)
Gunn J, Hegarty K, Nagle C, Forster D, Brown S and Lumley, J. Putting woman centered care into practice: A new approach to psychosocial risk assessment during pregnancy. Birth 33: 46–55 (2006)
Gurrin LC, Carlin JB, Sterne JAC, Dite GS and Hopper JL. Using bivariate models to understand between and within cluster regression coefficients, with application to twin data. Biometrics 62: 745–751 (2006)
Gussy M and Kilpatrick N. The self concept of adolescents with cleft lip and palate: A pilot study using a multidimensional/hierarchical measurement instrument. International Journal of Paediatric Dentistry 16: 335–341 (2006)
Gussy MG, Waters E and Kilpatrick NM. A qualitative study exploring barriers to a model of shared care for preschool children’s oral health. British Dental Journal 201: 165–170 (2006)
Gussy MG, Waters EG, Walsh O and Kilpatrick NM. Early childhood caries: Current evidence for aetiology and prevention. Journal of Paediatrics & Child Health 42: 37–43 (2006)
Hafen GM and Massie J. Lung contusion from focal low moderate chest trauma. Pediatric Pulmonology 41: 1005–1007 (2006)
Hafen GM, Ranganathan SC, Robertson CF and Robinson PJ. Clinical scoring systems in cystic fibrosis. Pediatric Pulmonology 41: 602–617 (2006)
Haile RW, Thomas DC, McGuire V, Felberg A, John EM, Milne RL, Hopper JL, Jenkins MA, Levine AJ, Daly MM, KconFab Investigators and others. BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50. Cancer Epidemiology Biomarkers & Prevention 15: 1863–1870 (2006)
Halamek LP and Morley C. Continuous positive airway pressure during neonatal resuscitation. Clinics in Perinatology 33: 83 (2006)
Hallam W, Olsson CA, Bowes G and Toumbourou JW. Being true to oneself: The role of authenticity in promoting youth mental health. Youth Studies Australia 25: 28–32 (2006)
Haller D, Sanci L, Sawyer S, Coffey C and Patton GR. U OK 2 TXT 4 RESEARCH? Feasibility of text message communication in primary care research. Australian Family Physician 35: 175–176 (2006)
Haller-Hester D. The year 2004: A depressing year for the treatment of depression in adolscence. Journal of Adolescent Health 36: 454–456 (2006)
Halliday J. Outcomes of IVF conceptions: Are they different? (advanced online publication) Best Practice & Research. Clinical Obstetrics & Gynaecology (2006)
Haloi AK, Ditchfield M and Maixner W. Mucocele of the sphenoid sinus. Pediatric Radiology 36: 987–990 (2006)
Hameed, R and Zacharin, MR. Cushing syndrome, adrenal suppression and local corticosteroid use. Journal of Paediatrics & Child Health 42: 392–394 (2006)
Hardikar W and Schwarz KB. Closing in on biliary atresia. Current Pediatric Reviews 2: 351–359 (2006)
Hardikar W and Schwarz KB. Treatment options for chronic hepatitis B and C infection in children. Expert Review of AntiInfective Therapy 4: 583–591 (2006)
Hargrove A and Curtis, N. Syphilis returns to the suburbs. European Journal of Pediatrics 165: 290–292 (2006)
Harrington AM, Hutson JM and Southwell BR. High affinity choline transporter immunoreactivity in rat ileum myenteric nerves (advanced online publication). Cell & Tissue Research (2006)
Harrington Z, Visvanathan K, Skinner NA, Curtis N, Currie BJ and Carapetis, JR. B cell antigen D8/17 is a marker of rheumatic fever susceptibility in Aboriginal Australians and can be tested in remote settings. Medical Journal of Australia 184: 507–0 (2006)
Harris K, Boots M, Talbot J and Vance A. Comparison of psychosocial correlates in primary school age children with attention deficit/ hyperactivity disorder combined type, with and without dysthymic disorder. Child Psychiatry & Human Development 36: 419–426 (2006)
Harrison D, Boyce S, Loughnan P, Dargaville P, Storm H and Johnston L. Skin conductance as a measure of pain and stress in hospitalised infants. Early Human Development 82: 603–608 (2006)
Harrison D, Loughnan P and Johnston L. Pain assessment and procedural pain management practices in neonatal units in Australia. Journal of Paediatrics & Child Health 42: 6–9 (2006)
Heath JA and Stern CJ. Fertility preservation in children newly diagnosed with cancer: Existing standards of practice in Australia and New Zealand. Medical Journal of Australia 185: 538–541 (2006)
Heath JA, Lintuuran RM, Rigguto G, Tikotlian N and McCarthy M. Childhood cancer: Its impact and financial costs for Australian families. Pediatric Hematology & Oncology 23: 439–448 (2006)
Heath JA, Mishra S, Mitchell S, Waters KD and Tiedemann K. Estrogen as treatment of hemorrhagic cystitis in children and adolescents undergoing bone marrow transplantation. Bone Marrow Transplantation 37: 523–526 (2006)
Heine RG, Jordan B, Lubitz L, Meehan M and Catto-Smith AG. Clinical predictors of pathological gastro oesophageal reflux in infants with persistent distress. Journal of Paediatrics & Child Health 42: 134–139 (2006)
Heine RG, Laske N and Hill DJ. The diagnosis and management of egg allergy. Current Allergy & Asthma Reports 6: 145–152 (2006)
Heine RG, Verstege A, Mehl A, Staden U, RolinckWerninghaus C and Niggemann B. Proposal for a standardized interpretation of the atopy patch test in children with atopic dermatitis and suspected food allergy. Pediatric Allergy & Immunology 17: 213–217 (2006)
Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Current Opinion in Allergy and Immunology 6: 220–225 (2006)
Hemphill SA and Littlefield L. Child and family predictors of therapy outcome for children with behavioral and emotional problems. Child Psychiatry & Human Development 36: 329–349 (2006)
Hemphill SA, Toumbourou JW, Herrenkohl TI, McMorris BJ, Catalano RF. The effect of school suspensions and arrests on subsequent adolescent antisocial behavior in Australia and the United States. Journal of Adolescent Health 39: 736–744 (2006)
Hildebrand MS, de Silva MG, Gardner RJ, Rose E, de Graaf CA, Bahlo M and Dahl HH. Cochlear implants for DFNA17 deafness. Laryngoscope 116: 2211–2215 (2006)
Hill MK and Sahhar M. Genetic counselling for psychiatric disorders. Medical Journal of Australia 185: 507–510 (2006)
Hiscock H, Bayer J, Gold L, Hampton A, Ukoumunne O and Wake M. Improving infant sleep and maternal mental health: A cluster randomised trial (advanced online publication). Archives of Disease in Childhood (2006)
Hiscock H, Canterford L, Ukoumunne O and Wake M. Adverse associations of sleep problems in Australian pre schoolers: National population study. Pediatrics 119: 86–93 (2006)
Hiscock H. The crying baby. Australian Family Physician 35: 680–684 (2006)
Hofman T, Cranswick N, Kuna P, Boznanski A, Latos T, Gold M, Murrell DF, Gebauer K, Behre U, Machura E, Olafsson J, Szalai Z, Int Tacrolimus Ointment Study Group. Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity in children. Archives of Disease in Childhood 91: 905–910 (2006)
Hogg GG, Darlington RJ, Hogg KG and Lester R. Measles immunity and immunisation status in Australian children 1 to 4 years of age. Journal of Paediatrics & Child Health 42: 165–169 (2006)
Hopyan S, Tan JW, Graham HK and Torode IP. Function and upright time following limb salvage, amputation, and rotationplasty for pediatric sarcoma of bone. Journal of Pediatric Orthopaedics 26: 405–408 (2006)
Howden SE, Wardan H, Voullaire L, McLenachan S, Williamson R, Ioannou P and Vadolas J. Chromatin binding regions of EBNA1 protein facilitate the enhanced transfection of epstein barr virus based vectors. Human Gene Therapy 17: 833–844 (2006)
Hughes NR, Pairojkul C, Royce SG, Clouston A and Bhathal PS. Liver fluke associated and sporadic cholangiocarcinoma: An immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes. Journal of Clinical Pathology 59: 1073–1078 (2006)
Hui J, Kirby DM, Thorburn DR an Boneh A. Decreased activities of mitochondrial respiratory chain complexes in non mitochondrial respiratory chain diseases. Developmental Medicine & Child Neurology 48: 132–136 (2006)
Hunt RW and Inder TE. Perinatal and neonatal ischaemic stroke: A review. Thrombosis Research 118: 39–48 (2006)
Hutchinson A and Johnston L. Beyond the barriers scale. Commonly reported barriers to research use. The Journal of Nursing Administration 36: 189–190 (2006)
Huxham F, Gong J, Baker R, Morris M and Iansek R. Defining spatial parameters for non linear walking. Gait & Posture 23: 159–163 (2006)
Hynson JL, Aroni R, Bauld C, Sawyer SM. Research with bereaved parents: A question of how not why. Palliative Medicine 20: 805–811 (2006)
Ignjatovic V, Furmedge J, Newall F, Chan A, Berry L, Fong C, Cheng K and Monagle, P. Age related differences in heparin response. Thrombosis Research 118: 741–745 (2006)
Ignjatovic V, Summerhayes R, Gan A, Than J, Chan A, Cochrane A, Bennett M, Horton S, Shann F, Lane G, RossSmith M and Monagle P. Monitoring unfractionated heparin therapy: Which anti factor Xa assay is appropriate? (advanced online publication) Thrombosis Research (2006)
Incharoen T, Thephinlap C, Srichairatanakool S, Chattipakorn S, Winichagoon P, Fucharoen S, Vadolas J and Chattipakorn N. Heart rate variability in beta thalassemic mice (advanced online publication). International Journal of Cardiology (2006)
Ismail D, Gebert R, Vuillermin PJ, Fraser L, McDonnell CM, Donath SM and Cameron FJ. Social consumption of alcohol in adolescents with Type 1 diabetes is associated with increased glucose lability, but not hypoglycaemia. Diabetic Medicine 23: 830–833 (2006)
Ismail D, O’Connell MA and Zacharin MR. Dexamphetamine use for management of obesity and hypersomnolence following hypothalamic injury. Journal of Pediatric Endocrinology & Metabolism 19: 129–134 (2006)
Jabbour AM, Puryer MA, Yu JY, Lithgow T, Riffkin CD, Ashley DM, Vaux DL, Ekert PG and Hawkins CJ. Human Bcl 2 cannot directly inhibit the Caenorhabditis elegans Apaf 1 homologue CED 4, but can interact with EGL 1. Journal of Cell Science 119: 2572–2582 (2006)
Jacquet JM, Begue P, Grimprel E, Reinert P, Sandbu S, Silfverdal SA, Faldella G, Nolan T, Lambert S, Richmond P, Marshall H, Roberton D and Schuerman, L. Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age: A review. Vaccine 24: 2440–2448 (2006)
James P, Parry S, Arnold J and Winship I. Confirming a diagnosis of hereditary colorectal cancer: The impact of a Familial Bowel Cancer Registry in New Zealand. New Zealand Medical Journal 119: U2168 (2006)
Jamsai D, Zaibak F, Vadolas J, Voullaire L, Fowler KJ, Gazeas S, Peters H, Fucharoen S, Williamson R and Ioannou PA. A humanized BAC transgenic/knockout mouse model for HbE/ beta thalassemia. Genomics 88: 309–315 (2006)
Jaques AM, Collins VR, Haynes K, Sheffield LJ, Francis I, Forbes R and Halliday JL. Using record linkage and manual follow up to evaluate the Victorian maternal serum screening quadruple test for Down’s syndrome, trisomy 18 and neural tube defects. Journal of Medical Screening 13: 8–13 (2006)
Jayasinghe Y and Garland, SM. Genital warts in children: what do they mean? Archives of Disease in Childhood 91: 696–700 (2006)
Jayasinghe Y, Moore P, Donath S, Campbell J and Monagle P. Bleeding disorders in teenagers presenting with menorrhagia. Australian & New Zealand Journal of Obstetrics & Gynaecology 45: 439–443 (2006)
Jenkins MA, Dharmage SC, Flander LB, Douglass JA, Ugoni AM, Carlin JB, Sawyer SM, Giles GG and Hopper, JL. Parity and decreased use of oral contraceptives as predictors of asthma in young women. Clinical & Experimental Allergy 36: 609–613 (2006)
Johnston L and Fineout-Overholt, E. Teaching EBP: Implementation of evidence-moving from evidence to action. Worldviews on Evidence-Based Nursing 3:4 194–200 (2006)
Johnston L and Fineout-Overholt E Teaching EBP. The Critical Step of Critically Appraising the Literature. Worldviews on Evidence-Based Nursing 3: 44–46 (2006)
Johnston L. Breatsfeeding the preterm infant: The importance of social bonds. Journal of Neonatal Nursing 12: 148–150 (2006)
Johnston L. Quality of life after surgical correction of congenital anorectal malformations and congenital disphragmatic hernia. Journal of Neonatal Nursing 12: 75–77 (2006)
Jones G, Ma D and Cameron FJ. Bone density interpretation and relevance in Caucasian children aged 9–17 years of age: insights from a population based fracture study. Journal of Clinical Densitometry 9: 202–209 (2006)
Jordan B, Heine RG, Meehan M, Catto-Smith AG and Lubitz L. Effect of antireflux medication, placebo and infant mental health intervention on persistent crying: a randomized clinical trial. Journal of Paediatrics & Child Health 42: 49–58 (2006)
Justice FA, Auldist AW and Bines JE. Intussusception: Trends in clinical presentation and management. Journal of Gastroenterology & Hepatology 21: 842–846 (2006)
Justice FA, de Campo M, Liem NT, Son TN, Ninh TP and Bines JE. Accuracy of ultrasonography for the diagnosis of intussusception in infants in Vietnam (advanced online publication). Pediatric Radiology (2006)
Kakakios A and Heine RG. Eosinophilic oesophagitis Medical Journal of Australia 185: 401 (2006)
Kalitsis P, Griffiths B and Choo KH. Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation. Proceedings of the National Academy of Sciences USA 103: 8786–8791 (2006)
Kamlin CO, O’Donnell CP, Everest NJ, Davis PG and Morley CJ. Accuracy of clinical assessment of infant heart rate in the delivery room. Resuscitation 71: 319–321 (2006)
Kamlin COF, O’Donnell CPF, Davis PG and Morley CJ. Oxygen saturation in healthy infants immediately after birth. Journal of Pediatrics 148: 585–589 (2006)
Kamlin, CF, Davis, PG and Morley, CJ. Predicting successful extubation of very low birthweight infants. Archives of Disease in Childhood — Fetal & Neonatal Edition 91: 0–0 (2006)
Kanetsky PA, Rebbeck TR, Hummer AJ, Panossian S, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Culver HA, Zanetti R, Gallagher RP, Dwyer T, Busam K, From L, Mujumdar U, Wilcox H, Begg CB and Berwick, M. Population based study of natural variation in the melanocortin-1 receptor gene and melanoma. Cancer Research 66: 9330–9337 (2006)
Kang HH, Williams R, Leary J, KconFab Investigators, Ringland C, Kirk J and Ward R. Evaluation of models to predict BRCA germline mutations. British Journal of Cancer 95: 914–920 (2006)
Kannu, P, Savarirayan, R, Ozoemena, L, White, SM and McGrath, JA. Rapp Hodgkin ectodermal dysplasia syndrome: The clinical and molecular overlap with Hay-Wells syndrome. American Journal of Medical Genetics Part A 0: 887–891 (2006)
Karl TR and Horton S. Centrifugal pump extracorporeal life support in paediatric cardiac surgery in Chang AC. In: Towbin JA (eds). Heart failure in children and young adults Saunders Elselvier (2006)
Karl TR, Horton SB and Brizard C. Postoperative support with the centrifugal pump ventricular assist device (VAD). Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual 83–91 (2006)
Karl TR, Kirschbom P and Horton SB. Mechanical circulatory support in infants and children. In: Nichols DG, Cameron DE, Ungerleider RM et al (eds). Critical heart disease in infants and children. Mosby Elsevier (2006)
Kelly JJ, Donath S, Jamsen K and Chalkiadis GA. Postoperative sleep disturbance in pediatric patients using patient controlled devices (PCA). Paediatric Anaesthesia 16: 1051–1056 (2006)
King SK, Southwell BR and Hutson JM. An association of multiple endocrine neoplasia 2B, a RET mutation, constipation, and low substance P nerve fiber density in colonic circular muscle. Journal of Pediatric Surgery 41: 437–442 (2006)
Kirkwood CD, Bogdanovic-Sakran N, Cannan D, Bishop RF and Barnes GL. National rotavirus surveillance program annual report, 2004–05. Communicable Diseases Intelligence 30: 133–136 (2006)
Klimek J, Morley CJ, Lau R and Davis PG Does measuring respiratory function improve neonatal ventilation? Journal of Paediatrics & Child Health 42: 140–142 (2006)
Korman SH, Pitt JJ, Boneh A, Dweikat I, Zater M, Meiner V, Gutman A and Brivet M. A novel SLC25A20 splicing mutation in patients of different ethnic origin with neonatally lethal carnitine acylcarnitine translocase (CACT) deficiency. Molecular Genetics & Metabolism 89: 332–338 (2006)
Korman SH. Inborn errors of isoleucine degradation: A review. Molecular Genetics & Metabolism 89: 289–299 (2006)
Kroenke CD, Bretthorst GL, Inder TE and Neil JJ. Modeling water diffusion anisotropy within fixed newborn primate brain using Bayesian probability theory. Magnetic Resonance Imaging 55: 187–197 (2006)
Lamande SR, Morgelin M, Adams NE, Selan C and Allen JM. The C5 domain of the collagen VI alpha3(VI) chain is critical for extracellular microfibril formation and is present in the extracellular matrix of cultured cells. Journal of Biological Chemistry 281: 16607–16614 (2006)
Lau WF, Zacharin MR, Waters K, Wheeler G, Johnston V and Hicks RJ. Management of paediatric thyroid carcinoma: Recent experience with recombinant human thyroid stimulating hormone in preparation for radioiodine therapy. Internal Medicine Journal 36: 564–570 (2006)
Lekgabe ED, Royce SG, Hewitson TD, Tang ML, Zhao C, Moore XL, Tregear GW, Bathgate RA, Du XJ and Samuel CS. The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs. Endocrinology 147: 5575–5583 (2006)
Lepore DA, Jokubaitis VJ, Simmons PJ, Roeszler KN, Rossi R, Bauer K and Thomas PQ. A role for angiotensin converting enzyme in the characterization, enrichment and proliferation potential of adult murine pituitary colony forming cells. Stem Cells. 24: 2382–2390 (2006)
Lewena S and Young S. When benzodiazepines fail: How effective is second line therapy for status epilepticus in children? Emergency Medicine Australasia 18: 45–50 (2006)
Lewis S, Curnow L, Ross M and Massie J. Parental attitudes to the identification of their infants as carriers of cystic fibrosis by newborn screening. Journal of Paediatrics & Child Health 42: 533–537 (2006)
Lewis SM, Cullinane FM, Carlin JB and Halliday JL. Women’s and health professionals’ preferences for prenatal testing for Down syndrome in Australia. Australian & New Zealand Journal of Obstetrics & Gynaecology 46: 205–211 (2006)
Lewis SM, Cullinane FN, Bishop AJ, Chitty LS, Marteau TM and Halliday JL. A comparison of Australian and UK obstetricians’ and midwives’ preferences for screening tests for Down syndrome. Prenatal Diagnosis 26: 60–66 (2006)
Li L, McVety S, Younan R, Liang P, Du Sart D, Gordon PH, Hutter P, Hogervorst FB, Chong G and Foulkes WD. Distinct patterns of germ-line deletions in MLH1 and MSH2: The implication of Alu repetitive element in the genetic etiology of Lynch syndrome (HNPCC). Human Mutation 27: 388–388 (2006)
Li S, Ferguson MJ, Hawkins CJ, Smith C and Elwood NJ. Human telomerase reverse transcriptase protects hematopoietic progenitor TF-1 cells from death and quiescence induced by cytokine withdrawal. Leukemia 20: 1270–1278 (2006)
Lim YW, Steinhoff M, Girosi F, Holtzman D, Campbell H, Boer R, Black R and Mulholland K. Reducing the global burden of acute lower respiratory infections in children: The contribution of new diagnostics. Nature 444: 9–18 (2006)
Linnane B, Hafen GM and Ranganathan SC. Diameter of paediatric sized flexible bronchoscopes: When size matters. Pediatric Pulmonology 41: 787–789 (2006)
Loeliger M, Inder T, Cain S, Ramesh RC, Camm E, Thomsom MA, Coalson J and Rees SM. Cerebral outcomes in a preterm baboon model of early versus delayed nasal continuous positive airway pressure. Pediatrics 118: 1640–1653 (2006)
Long E, Colquhoun S and Carapetis JR. Antibiotic prophylaxis for the prevention of recurrent urinary tract infections in children. Advances in Experimental Medicine & Biology 582: 243–249 (2006)
Loughlin E. Infertility: An unspoken presence in the lives of teens and young women with Turners syndrome in sexuality and fertility issues in ill health and disability. In: Balen R and Crawshaw M (eds). Sexuality and fertility issues in ill health and disability. Jessica Kingsley Press (2006)
Lovelock PK, Healey S, Au W, Sum EY, Tesoriero A, Wong EM, Hinson S, Brinkworth R, Bekessy A, Diez O, KconFab Investigators and others. Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants. Journal of Medical Genetics 43: 74–83 (2006)
Lovelock PK, Wong EM, Sprung CN, Marsh A, Hobson K, French JD, Southey M, KconFab Investigators, Sculley T, Pandeya N, Brown MA and others. Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability. Breast Cancer Research and Treatment (2006)
Low Y, Deshpande AV and Hutson JM. Lethal comorbidity with genital anomaly in the infant. Journal of Pediatric Urology 2: 534–538 (2006)
Lowe AJ,Carlin JB, Bennett CM, Abramson MJ, Hosking CS, Hill DJ and Dharmage SC. Atopic disease and breast feeding cause or consequence? Journal of Allergy & Clinical Immunology 117: 682–687 (2006)
Lucas RM, Ponsonby AL Considering the potential benefits as well as adverse effects of sun exposure: Can all the potential benefits be provided by oral vitamin D supplementation? Progress in Biophysics & Molecular Biology 92: 140–149 (2006)
Luck SN, Badea L, Bennett-Wood V, Robins-Browne RM and Hartland EL. Contribution of FliC to epithelial cell invasion by enterohemorrhagic Escherichia coli O113 H21. Infection & Immunity 74: 6999–7004 (2006)
Lum S, Gustafsson P, Ljungberg H, Hulskamp G, Bush A, Carr SB, Castle R, Hoo AF, Price JF, Ranganathan S, Stroobant J, Wade A, Wallis C, Wyatt H and Stocks J. Early detection of cystic fibrosis lung disease: multiple breath washout vs. raised volume tests (advanced online publication). Thorax (2006)
Ma FYP, Selber P, Nattrass GR, Harvey AR, Wolfe R and Graham HK. Lengthening and transfer of hamstrings for a flexion deformity of the knee in children with bilateral cerebral palsy: Technique and preliminary results. Journal of Bone & Joint Surgery — British Volume 88-B: 248–254 (2006)
Mackay, M. Epilepsy in childhood and adolescence. Medicine Today 7: 33–42 (2006)
Mackenzie G, Carapetis J, Leach A, Hare K and Morris P. Indirect effects of childhood pneumococcal vaccination on pneumococcal carriage among adults and older children in Australian Aboriginal communities (advanced online publication). Vaccine (2006)
MacLean HE, Favaloro JM, Warne GL and Zajac JD. Double strand DNA break repair with replication slippage on two strands: A novel mechanism of deletion formation. Human Mutation 27: 483–489 (2006)
Magnussen CG, Venn A, Dwyer T and Raitakari OT. Cardiovascular risk factors in childhood and carotid artery intima media thickness in adulthood: The childhood determinants of adult health study. Atherosclerosis Supplements 2006: 483–484 (2006)
Mahoney EK, Kilpatrick M and Swain MV. Behaviour of primary incisor caries: a micromechanical study. International Journal of Pediatric Dentistry 16: 270–277 (2006)
Maldonado-Saldivia J, van den Bergen J, Krouskos M, Gilchrist M, Li R, Sinclair AH, Surani MA and Western PS. Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line (advanced online publication). Stem Cells (2006)
Mangum JE, Veith PD, Reynolds EC, and Hubbard MJ. Towards second generation proteome analysis of murine enamel forming cells. European Journal of Oral Sciences 114: 259–265 (2006)
Manji SS, Sorensen BS, Klockars T, Lam T, Hutchison W and Dahl HH. Molecular characterization and expression of maternally expressed gene 3(Meg3/Gtl2) RNA in the mouse inner ear. Journal of Neuroscience Research 83: 181–190 (2006)
Mann GJ, Thorne H, Balleine RL, Butow PN, Clarke CL, Edkins E, Evans GM, Fereday S, Haan E, Gattas M, KconFab Investigators and others. Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research 2006 8: R12
Marsh A, Healey S, Lewis A, Spurdle AB, Kedda MA, Khanna KK, KconFab Investigators, Mann GJ, Pupo GM, Lakhani SR and Chenevix-Trench G. Mutation analysis of five candidate genes in familial breast cancer. Breast Cancer Research and Treatment (2006)
Marshall H, Nolan T, Roberton D, Richmond P, Lambert S, Jacquet JM, and Schuerman LA. A comparison of booster immunisation with a combination DTPa-IPV vaccine or DTPa plus IPV in separate injections when co administered with MMR at age 4–6 years. Vaccine 24: 6120–6128 (2006)
Maskari SN, Cochrane AD and Penny DJ. Unusual cause of persistent impairment of ventricular function after repair of coarctation of the aorta. Pediatric Cardiology 26: 836–838 (2006)
Massie J and Cranswick N. Pharmacokinetic profile of once daily intravenous tobramycin in children with cystic fibrosis. Journal of Paediatrics & Child Health 42: 601–605 (2006)
Massie J. Cough in children: When does it matter? Paediatric Respiratory Reviews 7: 9–14 (2006)
Mathers M, Toumbourou JW, Catalano RF, Williams J and Patton GC. Consequences of youth tobacco use: A review of prospective behavioural studies. Addiction 101: 948–958 (2006)
Mayosi B, Robertson K, Volmink J, Adebo W, Akinyore K, Amoah A, Bannerman C, Biesman-Simons S, Carapetis J, Cilliers A, Commerford P, Croasdale A, Damasceno A, Dean J, Dean M, De Souza R, Filipe A, Hugo-Hamman C, JurgensClur SA, Kombila-Koumba P, Kotzenberg C, Lawrenson J, Manga P, Matenga J, Mathivha T, Mntla P, Mocumbi A, Mokone T, Ogola E, Omokhodion S, Palweni C, Pearce A, Salo A, Thomas B, Walker K, Wiysonge C and Zaher S. The Drakensberg declaration on the control of rheumatic fever and rheumatic heart disease in Africa. South African Medical Journal 96: 246 (2006)
McCallum Z, Wake M, Gerner B, Baur LA, Gibbons K, Gold L, Gunn J, Harris C, Naughton G, Riess C, Sanci L, Sheehan J, Ukoumunne OC and Waters E. Outcome data from the LEAP (Live, Eat and Play) trial: A randomized controlled trial of a primary care intervention for childhood overweight/mild obesity (advanced online publication). International Journal of Obesity (2006)
McClorey G, Fall AM, Moulton HM, Iversen PL, Rasko JE, Ryan M, Fletcher S and Wilton SD. Induced dystrophin exon skipping in human muscle explants. Neuromuscular Disorders 16: 585–590 (2006)
McDonald M, Dougall A, Holt D, Huygens F, Oppedisano F, Giffard PM, Inman-Bamber J, Stephens AJ, Towers R, Carapetis JR and Currie BJ. Use of a single nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin resistant Staphylococcus aureus in remote Aboriginal communities. Journal of Clinical Microbiology 44: 3720–3727 (2006)
McDonald M, Towers R, Fagan P, McKinnon M, Benger N, Andrews R, Currie BJ and Carapetis JR. Recovering streptococci from the throat, a practical alternative to direct plating in remote tropical communities. Journal of Clinical Microbiology 44: 547–552 (2006)
McDonald MI, Towers RJ, Andrews RM, Benger N, Currie BJ and Carapetis JR. Low rates of streptococcal pharyngitis and high rates of pyoderma in Australian aboriginal communities where acute rheumatic fever is hyperendemic. Clinical Infectious Diseases 43: 683–689 (2006)
McDonald, MI, Benger, N, Brown, A, Currie, BJ and Carapetis, JR. Practical challenges of conducting research into rheumatic fever in remote Aboriginal communities. Medical Journal of Australia 184: 511–513 (2006)
McDonnell, CM and Zacharin, MR. Maternal primary hyperparathyroidism: Discordant outcomes in a twin pregnancy. Journal of Paediatrics & Child Health 42: 70–71 (2006)
McGinley JL, Morris ME, Greenwood KM, Goldie PA and Olney SJ. Accuracy of clinical observations of push off during gait after stroke. Archives of Physical Medicine & Rehabilitation 87: 779–785 (2006)
McGuire V, John EM, Felberg A, Haile RW, Boyd NF, Thomas DC, Jenkins MA, Milne RL, Daly MB, Ward J, KconFab Investigators and others. No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years. Cancer Epidemiology Biomarkers & Prevention 2006 15: 1565–1567
Mckenzie GA, Carapetis JR, Morris PS and Leach AJ. Current issues regarding the use of pneumococcal conjugate and polysaccharide vaccines in Australian children. Journal of Paediatrics & Child Health 41: 0–208 (2006)
McKenzie, M, Lazarou, M, Thorburn, DR and Ryan, MT. Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients. Journal of Molecular Biology 361: 462–469 (2006)
McMorris BJ, Hemphill SA, Toumbourou JW, Catalano RF and Patton GC. Prevalence of substance use and delinquent behavior in adolescents from Victoria, Australia and Washington, USA (advanced online publication). Health Education & Behaviour (2006)
McMullan DM, Oppido G, Alphonso N, Cochrane AD, d’Acoz YD and Brizard CP. Evaluation of downsized homograft conduits for right ventricle to pulmonary artery reconstruction. Journal of Thoracic and Cardiovascular Surgery 132: 66–71 (2006)
McVernon J, Slack MPE and Ramsay ME. Changes in the epidemiology of epiglottitis following introduction of Haemophilus influenzae type b (Hib) conjugate vaccines in England: A comparison of two data sources. Epidemiology & Infection 134: 570–572 (2006)
Menahem S, Anderson RH. Cleft mitral valve in transposition with intact ventricular septum. Cardiology in the Young 14: 550–552 (2006)
Mewes AUJ, Huppi P, Als H, Rybicki FY, Inder TE, McAnulty G, Mulkern RV, Robertson R, Rivkin M and Warfield SK. Regional brain development in serial magnetic resonance imaging of low risks preterm infants. Pediatrics 118: 23–33 (2006)
Miller J. Skills, bravery, courage and foolhardiness: 75 years of social work in health care in Melbourne, Australia. Social Work in Health Care 43: 173–191 (2006)
Millikan RC, Hummer A, Begg C, Player J, de Cotret AR, Winkel S, Mohrenweiser H, Thomas N, Armstrong B, Kricker A, Marrett LD, Gruber SB, Culver HA, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Busam K, From L, Mujumdar U and Berwick M. Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: The Genes Environment and Melanoma Study. Carcinogenesis 2006: 610–618 (2006)
Mishra UK, Jacobs SE, Doyle LW and Garland SM. Newer approaches to the diagnosis of early onset neonatal sepsis. Archives of Disease in Childhood — Fetal & Neonatal Edition 91: F208–F212 (2006)
Mitra B, Cameron PA, Butt W and Rosenfeld JV. Children or young adults? A population based study on adolescent head injury. Australian & New Zealand Journal of Surgery 76: 343–350 (2006)
Monagle P, Barnes C, Ignjatovic V, Furmedge J, Newall F, Chan A, De Rosa L, Hamilton S, Ragg P, Robinson S, Auldist A, Crock C, Roy N and Rowlands S. Developmental haemostasis. Impact for clinical haemostasis laboratories. Thrombosis & Haemostasis 95: 362–372 (2006)
Mookerjee I, Solly NR, Royce SG, Tregear GW, Samuel CS and Tang MLK. Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease. Endocrinology 147: 754–761 (2006)
Moran P, Coffey C, Mann A, Carlin JB and Patton GC. Dimensional characteristics of DSM-IV personality disorders in a large epidemiological sample. ACTA Psychiatrica Scandinavica 113: 233–236 (2006)
Moran P, Coffey C, Mann A, Carlin JB and Patton GC. Personality and substance use disorders in young adults. British Journal of Psychiatry 188: 374–379 (2006)
Morley R, Carlin JB, Pasco JA and Wark JD. Maternal 25hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. Journal of Clinical Endocrinology & Metabolism 91: 906–912 (2006)
Morley R, Dwyer T and Carlin JB. Studies of twins: What can they tell us about the developmental origins of adult health and disease? Advances in Experimental Medicine & Biology 573: 29–40 (2006)
Morley R, McCalman J and Carlin JB. Birthweight and coronary heart disease in a cohort born 1857–1900 in Melbourne, Australia. International Journal of Epidemiology 35: 880–885 (2006)
Morley R, Umstad MP, Bond J, Moore VM, Owens JA, Dwyer T and Carlin, JB. Maternal dietary intake in twin pregnancies: Does it diminish towards term? Twin Research & Human Genetics 9: 656–658 (2006)
Morley R. Fetal origins of adult disease. Seminars In Fetal & Neonatal Medicine 11: 73–78 (2006)
Muggli EE, Collins VR and Halliday JL. Mapping uptake of prenatal diagnosis for Down syndrome and other chromosome abnormalities across Victoria, Australia. Australian & New Zealand Journal of Obstetrics & Gynaecology 46: 492–500 (2006)
Muggli EE, McCloskey D and Halliday JL. Health behaviour modelling for prenatal diagnosis in Australia: A geodemographic framework for health service utilisation and policy development. BMC Health Services Research 6: 109 (2006)
Muggli EE. Data collections on congenital disabilities: More than just numbers. Journal of Intellectual & Developmental Disability 31: 243–245 (2006)
Mulholland K. Perspectives on the burden of pneumonia in children (advanced online publication). Vaccine (2006)
Murthi P, Doherty V, Said J, Donath S, Brennecke SP and Kalionis B. Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. American Journal of Pathology 168: 511–518 (2006)
Murthi P, Doherty VL, Said JM, Donath S, Brennecke SP and Kalionis, B. Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction. Molecular Human Reproduction 12: 335–340 (2006)
Murthi P, Said JM, Doherty VL, Donath S, Nowell CJ, Brennecke SP and Kalionis, B. Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction. Molecular Human Reproduction 2006: 763–769 (2006)
Muscat A, Hawkins C and Ashley DM. Caspase 8 levels correlate with the expression of signal transducer and activator of transcription 1 in high grade but not lower grade neuroblastoma. Cancer 107: 824–831 (2006)
Nagle C, Lewis S, Meiser B, Metcalfe S, Carlin JB, Bell R, Gunn J and Halliday J. Evaluation of a decision aid for prenatal testing of fetal abnormalities: A cluster randomised trial [ISRCTN22532458]. BMC Public Health 6: 96– (2006)
Namachivayam P and Tibballs J. Methylene blue for diagnosis of displaced atrial lines. Anaesthesia & Intensive Care 34: 280–281 (2006)
Namachivayam P, Crossland DS, Butt WW and Shekerdemian LS. Early experience with Levosimendan in children with ventricular dysfunction. Pediatric Critical Care Medicine 7: 445–448 (2006)
Namachivayam, P, Theilen, U, Butt, WW, Cooper, SM, Penny, DJ, Shekerdemian, LS. Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children. American Journal of Respiratory & Critical Care Medicine 174: 1042–1047 (2006)
Navakatikyan MA, Colditz PB, Burke CJ, Inder TE, Richmond J and Williams CJ. Seizure detection algorithm for neonates based on wave-sequence analysis. Clinical Neurophysiology 117: 1190–1203 (2006)
Newall F and Bauman M. Point of care antithrombotic monitoring in children. Thrombosis Research 118: 113–121 (2006)
Newall F, Johnston L and Monagle P. A survey of pediatric cardiology nurses’ understanding of warfarin therapy. Pediatric Cardiology 27: 204–208 (2006)
Newall F, Monagle P and Johnston L. Home INR monitoring of oral anticoagulant therapy in children using the CoaguChek S point of care monitor and a robust education program. Thrombosis Research 118: 587–593 (2006)
Newall F, Wallace T, Crock C, Campbell J, Savoia H, Barnes C and Monagle P. Venous thromboembolic disease: A single centre case series study. Journal of Paediatrics & Child Health 42: 803–807 (2006)
Newcomb AE, Negri JC, Brizard CP and d’Udekem Y. Successful left ventricular assist device bridge to transplantation after failure of a fontan revision. Journal of Heart & Lung Transplantation 25: 365–367 (2006)
Newton HJ, Sansorn FA, Bennett-Wood V and Hartland EL. Identification of Legionella pneumophila specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry. Infection & Immunity 74: 1683–1691 (2006)
Nguyen AT, Brown JJ and Warne GL. Growth in congenital adrenal hyperplasia. Indian Journal of Pediatrics 73: 89–93 (2006)
Nguyen ATT, Zacharin MR, Smith M and Hardikar W. Isolated intestinal ganglioneuromatosis with a new mutation of RET proto oncogene. European Journal of Gastroenterology & Hepatology 18: 803–805 (2006)
Nguyen RN, Taylor LS, Tauschek M and Robins-Browne RM. Atypical enteropathogenic Escherichia coli infection and prolonged diarrhea in children. Emerging Infectious Diseases 12: 597–603 (2006)
Nguyen T and Zacharin MR. Pamidronate treatment of steroid associated osteonecrosis in young patients treated for acute lymphoblastic leukaemia: Two year outcomes. Journal of Pediatric Endocrinology & Metabolism 19: 161–167 (2006)
Niggemann B and Heine RG. Who should manage infants and young children with food induced symptoms? Archives of Disease in Childhood 91: 379–382 (2006)
Nisselle AE, Collins VR, Gason AA, Flouris A, Delatycki MB, Allen KJ, Aitken MA, Metcalfe SA. Educational outcomes of a workplace screening program for genetic susceptibility to hemochromatosis. Clinical Genetics 69: 163–170 (2006)
Nolan T, Bernstein H, Blatte, MM, Bromberg K, Guerra F, Kennedy W, Pichichero M, Senders SD, Trofa A, Collard A, Sullivan DC and Descamps D. Immunogenicity and safety of an inactivated hepatitis A vaccine administered concomitantly with diphtheria-tetanus acellular pertussis and haemophilus influenzae type B vaccines to children less than 2 years of age. Pediatrics 118: 0–0 (2006)
Nolen LD, Amor D, Haywood A, Heaps LS, Willcock C, Mihelec M, Tam,P, Billson F, Grigg J, Peters G and Jamieson RV. Deletion at 14q22–23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. American Journal of Medical Genetics Part A 0: 1711–1718 (2006)
Norgaard MA, Alphonso N, Cochrane AD, Menahem S, Brizard CP and d’Udekem, Y. Major aorto-pulmonary collateral arteries of patients with pulmonary atresia and ventricular septal defect are dilated bronchial arteries. European Journal of Cardio-Thoracic Surgery 29: 653–658 (2006)
Norgaard MA, Alphonso N, Newcomb AE, Brizard CP and Cochrane AD. Absent pulmonary valve syndrome. Surgical and clinical outcome with long term follow up. European Journal of Cardio-Thoracic Surgery 29: 682–687 (2006)
Northam EA, Rankins D and Cameron FJ. Therapy insight: The impact of type 1 diabetes on brain development and function. Nature Clinical Practice. Neurology. 2: 78–86 (2006)
Northam EA, Todd S and Cameron FJ. Interventions to promote optimal health outcomes in children with Type 1 diabetes — are they effective? Diabetic Medicine 23: 113–121 (2006)
Nydegger A and Bines JE. Energy metabolism in infants with congenital heart disease. Nutrition 22: 697–704 (2006)
Nydegger A, Catto-Smith AG, Tiedemann K and Hardikar W. Diagnosis of gastrointestinal graft-versus-host disease — Is rectal biopsy enough? (advanced online publication) Pediatric Blood & Cancer (2006)
Nydegger A, Couper RTL and Oliver MR. Childhood pancreatitis. Journal of Gastroenterology & Hepatology 21: 499–509 (2006)
Oakley E, Stocker S, Staubli G and Young S. Using video recording to identify management errors in pediatric trauma resuscitation. Pediatrics 117: 658–664 (2006)
O’Donnell CP and Morley CJ. Paralyzed right hemidiaphragm in a newborn infant. Journal of Pediatrics 149: 730– (2006)
O’Donnell CP, Gibson AT and Davis PG. Pinching, electrocution, ravens’ beaks, and positive pressure ventilation: A brief history of neonatal resuscitation Archives of Disease in Childhood — Fetal & Neonatal Edition 91: F369–F373 (2006)
O’Donnell CPF, Kamlin COF, Davis PG and Morley CJ. Endotracheal intubation attempts during neonatal resuscitation: Success rates, duration and adverse effects. Pediatrics 117: E16–E21 (2006)
O’Donnell CPF, Kamlin COF, Davis PG, Carlin JB and Morley, CJ. Interobserver variability of the 5 minute Apgar score. Journal of Pediatrics 149: 486–489 (2006)
O’Grady JG, Hardy P, Burroughs AK, Elbourne D et al. Randomized controlled trial of tacrolimus versus microemulsified cyclosporin (TMC) in liver transplantation: Poststudy surveillance to 3 years. American Journal of Transplantation (2006)
O’Sullivan,R, Oakley E and Starr M. Wound repair in children. Australian Family Physician 35: 476–479 (2006)
Pagnamenta AT, Taanman JW, Wilson CJ, Anderson NE, Marotta R, Duncan AJ, Bitner-Glindzicz M, Taylo, RW, Laskowski A, Thorburn DR and Rahman, S. Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma. Human Reproduction 21: 2467–2473 (2006)
Palmer GM, Frawley GP, Heine RG, Oliver MR. Complications associated with endoscopic removal of percutaneous endoscopic gastrostomy (PEG) tubes in children. Journal of Pediatric Gastroenterology & Nutrition 42: 443–445 (2006)
Pardo J, Urban C, Galvez EM, Ekert PG, Muller U, KwonChung J, Lobigs M, Mullbacher A, Wallich R, Borner C and Simon MM. The mitochondrial protein Bak is pivotal for gliotoxin induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. Journal of Cell Biology 174: 509–519 (2006)
Pathak, MS, Nguyen HT, Graham HK and Moore AP. Management of spasticity in adults: Practical application of botulinum toxin. European Journal of Neurology 13: 42–50 (2006)
Patradoon-Ho P, Gunkesera H, Ryan MM and Amber GR. Inhaled corticosteroids, adrenal suppression and benign intracranial hypertension. Medical Journal of Australia 185: 279–280 (2006)
Patton GC, Bond L, Carlin JB, Thomas L, Butler H, Glover S, Catalano R and Bowes G. Promoting social inclusion in schools: A group-randomized trial of effects on student health risk behavior and well-being. American Journal of Public Health 96: 1582–1587 (2006)
Patton GC, Coffey C, Carlin JB, Sawyer SM, Wakefield M. Teen smokers reach their mid twenties. Journal of Adolescent Health 39: 214–220 (2006)
Peacock S, Apicella C, Andrews L, Tucker K, Bankie, A, Daly MB and Hopper JL. A discrete choice experiment of preferences for genetic counselling among Jewish women seeking cancer genetics services. British Journal of Cancer 95: 1448–1453 (2006)
Pedreira CC, Stargatt R, Maroulis H, Rosenfeld J, Maixner W, Warne GL and Zacharin MR. Health related quality of life and psychological outcome in patients treated for craniopharyngioma in childhood. Journal of Pediatric Endocrinology & Metabolism 19: 15–24 (2006)
Pedreira, CC, Hameed, R, Kanumakala S and Zacharin, M. Health care problems of Turner syndrome in the adult woman: a cross sectional study of a Victorian cohort and a case for transition. Internal Medicine Journal 36: 54–57 (2006)
Penny, DJ. The systemic delivery and consumption of oxygen in the infant after cardiac surgery. Cardiology in the Young 16: 144–150 (2006)
Pereira PM and Bines JE. New growth factor therapies aimed at improving intestinal adaptation in short bowel syndrome. Journal of Gastroenterology & Hepatology 21: 932–940 (2006)
Phillips KA, Jenkins MA, Lindeman GJ, McLachlan SA, McKinley JM, Weideman PC, Hopper JL, Friedlander ML and KconFab Investigators. Risk-reducing surgery, screening and chemoprevention practices of BRCA1 and BRCA2 mutation carriers: a prospective cohort study. Clinical Genetics 70: 198–206 (2006)
Piers EF, Daubeney AW, Nugent PC, Carlin JB, Colan SD, Cheung M, Davis AM, Chow W and Weintraub RG. National Australian childhood cardiomyopathy study. Clinical features and outcomes of childhood dilated cardiomyopathy: Results from a national population based study. Circulation 114: 2671–2678 (2006)
Ponsonby AL, Dwyer T, van der Mei I, Kemp A, Blizzard L, Taylor B, Kilpatrick T and Simmons R. Asthma onset prior to multiple sclerosis and the contribution of sibling exposure in early life. Clinical & Experimental Immunology 146: 463–470 (2006)
Ponsonby AL, Lucas RM and Van Der Mei IA. UVR, vitamin D and three autoimmune diseases: Multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochemistry & Photobiology 81: 1267–1275 (2006)
Poomthavorn P and Zacharin M. Early manifestation of obesity and calcinosis cutis in infantile pseudohypoparathyroidism. Journal of Paediatrics & Child Health 42: 821–823 (2006)
Powell LW, Dixon JL, Ramm GA, Purdie DM, Lincoln DJ, Anderson GJ, Subramaniam VN, Hewett DG, Searle JW, Fletcher LM, Crawford DH, Rodgers H, Allen KJ, Cavanaugh JA and Bassett ML. Screening for hemochromatosis in asymptomatic subjects with or without a family history. Archives of Internal Medicine 166: 294–301 (2006)
Priestley JD and Berkowitz RG. Closure of tracheocutaneous fistula in children. International Journal of Pediatric Otorhinolaryngology 70: 1357–1359 (2006)
Priestley S, Babl FE, Krieser D, Law A, Miller J, Spicer M and Tully M. Evaluation of the impact of a paediatric procedural sedation credentialing programme on quality of care. Emergency Medicine Australasia 18: 498–504 (2006)
Puryer, MA and Hawkins, CJ. Human, insect and nematode caspases kill Saccharomyces cerevisiae independently of YCA1 and Aif1p. Apoptosis 11: 509–517 (2006)
Quigley A, Lowes K, Kornberg AJ, Cook MJ and Kapsa, R. Therapeutic DNA delivery to skeletal muscle. Current Genomics 7: 179–190 (2006)
Raetzman LT, Wheeler BS, Ross SA, Thomas PQ and Camper, SA.Persistent expression of Notch2 delays gonadotrope differentiation. Molecular Endocrinology 20: 2898–2908 (2006)
Ranganathan S, Connell T and Curtis N. Interferon gamma release assays in children: No better than tuberculin skin testing? (advanced online publication) Journal of Infection (2006)
Rankins D, Bradshaw JL and Georgiou-Karistianis N. The semantic Simon effect in Tourette’s syndrome and obsessive compulsive disorder. Brain & Cognition 61: 225–234 (2006)
Reddihough, D. Visual diagnosis in pediatrics. Journal of Paediatrics & Child Health 42: 828– (2006)
Reid J, Kilpatrick N and Reilly S. A prospective, longitudinal study of feeding skills in a cohort of babies with cleft conditions. Cleft Palate — Craniofacial Journal 43: 702–709 (2006)
Reid S, Halliday J, Ditchfield M, Ekert H, Byron K, Glynn A, Petrou V and Reddihough D. Factor V Leiden mutation: A contributory factor for cerebral palsy? Developmental Medicine & Child Neurology 48: 14–19 (2006)
Reid SM, Lanigan A and Reddihough DS. Post neonatally acquired cerebral palsy in Victoria, Australia, 1970–1999. Journal of Paediatrics & Child Health 42: 606–611 (2006)
Reilly S, Eadie P, Bavin EL, Wake M, Prior M, Williams J, Bretherton L, Barrett Y and Ukoumunne OC. Growth of infant communication between 8 and 12 months: A population study. Journal of Paediatrics & Child Health 42: 764–770 (2006)
Reilly, S. Communication and swallowing disorders associated with congenital syndromes. Advances in Speech-Language Pathology 8: 1– (2006)
Rinehart NJ, Tonge BJ, Iansek R, McGinley J, Brereton AV, Enticott PG and Bradshaw JL. Gait function in newly diagnosed children with autism: Cerebellar and basal ganglia related motor disorder. Developmental Medicine & Child Neurology 48: 819–824 (2006)
Riordan SM, Skinner NA, Kurtovic J, Locarnini S, McIver CJ, Williams R and Visvanathan K. Toll like receptor expression in chronic hepatitis C: Correlation with pro-inflammatory cytokine levels and liver injury. Inflammation Research 55: 279–285 (2006)
Roberts G, Bellinger D and McCormick MC. A cumulative risk factor model for early identification of academic difficulties in premature and low birth weight infants (advanced online publication). Maternal & Child Health Journal (2006)
Robertson CF, Price D, Henry R, Mellis C, Glasgow N, Fitzgerald D, Lee AJ, Turner J and Sant M. Short course montelukast for intermittent asthma cn Children: A randomised controlled trial (advanced online publication). American Journal of Respiratory & Critical Care Medicine (2006)
Robin NH, Taylo, CJ, McDonald-McGinn DM, Zackai EH, Bingham P, Collins KJ, Earl D, Gill D, Granata T, Guerrini R, Katz N, Kimonis V, Lin JP, Lynch DR, Mohammed SN, Massey RF, McDonald M, Rogers RC, Splitt M, Stevens CA and Tischkowitz MD. Polymicrogyria and deletion 22q11.2 syndrome: Window to the etiology of a common cortical malformation. American Journal of Medical Genetics Part A 140: 2416–2425 (2006)
Robins-Browne RM. Treatment and prevention of travellers’ diarrhoea. Australian Journal of Pharmacy 87: 62–65 (2006)
Rodda JM, Graham HK, Nattrass GR, Galea MP, Baker R and Wolfe R. Correction of severe crouch gait in patients with spastic diplegia with use of multilevel orthopaedic surgery. Journal of Bone & Joint Surgery — American Volume 88: 2653–2664 (2006)
Rosenthal MA, Drummond KJ, Dally M, Murphy M, Cher L, Ashley D, Thursfield V and Giles GG. Management of glioma in Victoria (1998–2000): Retrospective cohort study. Medical Journal of Australia 184: 270–273 (2006)
Rotenberg BW and Berkowitz RG. Changing trends in the success rate of anterior cricoid split. Annals of Otology Rhinology and Laryngology 115: 833–836 (2006)
Rubin KH, Hemphill SA, Chen XY, Hastings P, Sanson A, Lo Coco A, Zappulla C, Chung OB, Park SY, Doh HS, Chen HC, Sun L, Yoon CH and Cui LY. A cross-cultural study of behavioral inhibition in toddlers: East West North South. International Journal of Behavioural Development 30: 219–226 (2006)
Russell FM, Biribo SSN, Selvaraj G, Oppedisano F, Warren S, Seduadua A, Mulholland EK and Carapetis, JR. As a bacterial culture medium, citrated sheep blood agar is a practical alternative to citrated human blood agar in laboratories of developing countries. Journal of Clinical Microbiology 44: 3346–3351 (2006)
Russell FM, Carapetis JR, Ketaiwai S, Kunabuli V, Taoi M, Biribo S, Seduadua A and Mulholland EK. Pneumococcal nasopharyngeal carriage and patterns of penicillin resistance in young children in Fiji. Annals of Tropical Paediatrics 26: 187–197 (2006)
Ryhammer PK, Shekerdemian LS, Penny DJ and Ravn HB. Effect of intravenous sildenafil on pulmonary hemodynamics and gas exchange in the presence and absence of acute lung injury in piglets. Pediatric Research 59: 762–766 (2006)
Sadleir LG, Farrell K, Smith S, Connolly MB and Scheffer, IE. Electroclinical features of absence seizures in childhood absence epilepsy. Neurology 67: 413–418 (2006)
Sale SM, Read JA, Stoddart PA and Wolf AR. Prospective comparison of sevoflurane and desflurane in formerly premature infants undergoing inguinal herniotomy. British Journal of Anaesthesia 96: 774–778 (2006)
Sanci L, Vance A, Haller D, Patton G and Chanen A. Common mental health problems in adolescence. In Blashki G, Jud F and Piterman L (eds). General Practice Psychiatry. Sydney: McGraw Hill (2006)
Sanghera N, Chan PY, Khaki ZF, Planner C, Lee KKC, Cranswick NE and Wong, ICK. Interventions of hospital pharmacists in improving drug therapy in children: A systematic literature review. Drug Safety 29: 1031–1047 (2006)
Savulescu J, Foddy B and Rogers J. What should we say? Journal of Medical Ethics 32: 7–12 (2006)
Savulescu J, Hemsley M, Newson A and Foddy B. Behavioural genetics: Why eugenic selection is preferable to enhancement. Journal of Applied Philosophy 23: 157–171 (2006)
Sawyer MG, Miller-Lewis L, Guy S, Wake M, Canterford L and Carlin JB. Is there a relationship between overweight and obesity and mental health problems in 4 to 5 year old Australian children? Ambulatory Pediatrics 6: 306–311 (2006)
Sawyer SM, Cerritelli B, Carter LS, Cooke M, Glazner JA and Massie J. Changing their minds with time: A comparison of hypothetical and actual reproductive behaviors in parents of children with cystic fibrosis. Pediatrics 118: e649–e656 (2006)
Sawyer SM, Cooke R, Conn J, Marks MK, Roseby R and Cerritelli B. Improving medical student performance in smoking health promotion: Effect of a vertically integrated curriculum. Medical Teacher 28: e135–e138 (2006)
Sawyer SM. Asthma friendly schools: The importance of school policy for children with asthma. Journal of Paediatrics & Child Health 42: 483–485 (2006)
Schache AG and Baker R. On the expression of joint moments during gait (advanced online publication). Gait & Posture (2006)
Schache AG, Baker R and Lamoreux LW. Defining the knee joint flexion extension axis for purposes of quantitative gait analysis: an evaluation of methods. Gait & Posture 24: 100–109 (2006)
Schache AG, Baker R and Vaughan CL. Differences in lower limb transverse plane joint moments during gait when expressed in two alternative reference frames. Journal of Biomechanics 40: 9–19 (2006)
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W and Caffeine for Apnea of Prematurity Trial Group. Caffeine therapy for apnea of prematurity. New England Journal of Medicine 354: 2112–2121 (2006)
Schmidt B, Roberts RS, Fanaroff A, Davis P, Kirpalani HM, Nwaesei C, Vincer M and TIPP Investigators. Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: Further analyses from the trial of indomethacin prophylaxis in preterms (TIPP). Journal of Pediatrics 148: 730–734 (2006)
Schwartz MH, Koop SE, Bourke JL and Baker R. A nondimensional normalization scheme for oxygen utilization data. Gait & Posture 24: 14–22 (2006)
Selvaraj G, Kirkwood C, Bines J and Buttery J. Molecular epidemiology of adenovirus isolates from patients diagnosed with intussusception in Melbourne, Australia. Journal of Clinical Microbiology 44: 3371–3373 (2006)
Sethi D, Aljunid S, Sulong BS, Clemens F, Hardy P, Elbourne D and Zwi A. Comparison of the effectiveness of trauma services provided by secondary and tertiary hospitals in Malaysia. Annals of Emergency Medicine (2006)
Shah DK, Anderson PJ, Carlin JB, Pavlovic M, Howard K, Thompson DK, Warfield SK and Inder TE. Reduction in cerebellar volumes in preterm infants: relationship to white matter injury and neurodevelopment at two years of age. Pediatric Research 60: 97–102 (2006)
Shah DK, Guinane C, August P, Austin NC, Woodward LJ, Thompson DK, Warfield SK, Clemett R and Inder TE. Reduced occipital regional volumes at term predict impaired visual function in early childhood in very low birth weight infants. Investigative Opthamology & Visual Science 47: 3366–3373 (2006)
Shah DK, Lavery S, Doyle LW, Wong C, McDougall P and Inder, TE. Use of 2 channel bedside electroencephalogram monitoring in term born encephalopathic infants related to cerebral injury defined by magnetic resonance imaging. Pediatrics 118: 47–55 (2006)
Shah K, Kirkwood CD, Bhave M and Palombo EA. Genetic variation of NSP1 and NSP4 genes among serotype G9 rotaviruses causing hospitalization of children in Melbourne, Australia, 1997–2002. Journal of Medical Virology 78: 1124–1130 (2006)
Shah S, Bell RJ, Savage G, Goldstat R, Papalia MA, Kulkarni J, Donath S and Davis SR. Testosterone aromatization and cognition in women: A randomized, placebo-controlled trial. Menopause — The Journal of the North American Menopause Society 13: 600–608 (2006)
Shann F. Warfare and the state of the world’s children Advances in Experimental Medicine & Biology 582: 1–7 (2006)
Shekerdemian L and Bohn D. Acute viral myocarditis: Epidemiology & pathophysiology Pediatric Critical Care Medicine 7: 52–57 (2006)
Shenker NS, Huynh J, Farmer PJ and Hutson JM. A new role for androgen in testicular descent: permitting gubernacular cell proliferation in response to the neuropeptide, calcitonin gene-related peptide. Journal of Pediatric Surgery 41: 407–412 (2006)
Shoemark, H. Infant directed singing as a vehicle for regulation rehearsal in the medically fragile full term unfant. Australian Journal of Music Therapy 17: 54–63 (2006)
Shortt A, Toumbourou JW and Chapman R. The resilient families program: Helping to prepare adolescents for success in school and life. Youth Studies Australia 25: 57–58 (2006)
Shortt A, Toumbourou JW, Chapman R and Power E. The resilient families program: Promoting health and wellbeing in adolescents and their parents during the transition to secondary school. Youth Studies Australia 25: 33–40 (2006)
Shortt AL and Spence SH. Risk and protective factors for depression in youth. Behaviour Change 23: 1–30 (2006)
Siahpush M and Carlin JB. Financial stress, smoking cessation and relapse: results from a prospective study of an Australian national sample. Addiction 101: 121–127 (2006)
Siemering K, Manji SS, Hutchison WM, Du Sart D, Phelan D and Dahl HH. Detection of mutations in genes associated with hearing loss using a microarray based approach. Journal of Molecular Diagnostics 8: 483–0 (2006)
Simm PJ and Zacharin MR. The psychosocial impact of Klinefelter syndrome: A 10 year review. Journal of Pediatric Endocrinology & Metabolism 19: 499–505 (2006)
Simpson CM, Penny DJ, Cochrane AD, Davis AM, Rose ML, Wilson SE and Weintraub RG. Preliminary experience with bosentan as initial therapy in childhood idiopathic pulmonary arterial hypertension. Journal of Heart & Lung Transplantation 25: 469–473 (2006)
Simpson CM, Sterne JA, Walker RG, Francis DM, Robertson AJ and Jones CL. Stent related ureteric obstruction in paediatric renal transplantation. Pediatric Nephrology 21: 79–85 (2006)
Simpson MJ, Landman KA and Newgreen, DF. Chemotactic and diffusive migration on a nonuniformly growing domain: Numerical algorithm development and applications. Journal of Computational & Applied Mathematics 192: 282–300 (2006)
Simpson,MJ, Landman KA, Hughes BD and Newgreen DF. Looking inside an invasion wave of cells using continuum models: Proliferation is the key. Journal of Theoretical Biology 243: 343–360 (2006)
Skok A, Harvey D and Reddihough D. Perceived stress, perceived social support, and wellbeing among mothers of school aged children with cerebral palsy. Journal of Intellectual & Developmental Disability 31: 53–57 (2006)
Smith A, Ho SY, Anderson RH, Connell MG, Arnold R, Wilkinson JL and Cook AC. The diverse cardiac morphology seen in hearts with isomerism of the atrial appendages with reference to the disposition of the specialised conduction system. Cardiology in the Young 16: 437–454 (2006)
Smith L, Tesoriero A, Mead L, Royce SG, Grubb G, Young J, Giles G, Jenkins M, Macrae F, Hopper JL and Southey MC. Large genomic alterations in hMSH2 and hMLH1 in early onset colorectal cancer: identification of a large complex de novo hMLH1 alteration. Clinical Genetics 70: 250–252 (2006)
Smith P, McGuffog L, Easton DF, Mann GJ, Pupo GM, Newman B, Chenevix-Trench G, KconFab Investigators, Szabo C, Southey M, Renard H and others. A genome wide linkage search for breast cancer susceptibility genes. Genes, Chromosomes and Cancer 45: 646–655 (2006)
Snape KM, Fahey MC, McGillivray G, Gupta P, Milewicz DM and Delatycki MB. Long term survival in a child with severe congenital contractural arachnodactyly, autism and severe intellectual disability. Clinical Dysmorphology 15: 95–99 (2006)
Soo B, Howard JJ, Boyd RN, Reid SM, Lanigan A, Wolfe R, Reddihough D and Graham HK. Hip displacement in cerebral palsy. Journal of Bone & Joint Surgery — American Volume 88: 121–129 (2006)
Southwell BR. Staging of intestinal development in the chick embryo. Anatomy Record Part A — Discoveries in Molecular, Cellular & Evolutionary Biology 288: 909–920 (2006)
Spooner CG, Berkovic SF, Mitchell LA, Wrennall JA and Harvey, AS. New onset temporal lobe epilepsy in children: lesion on MRI predicts poor seizure outcome. Neurology 67: 2147–2153 (2006)
Stargatt R, Davidson AJ, Huang GH, Czarnecki C, Gibson MA, Stewart SA and Jamsen K. A cohort study of the incidence and risk factors for negative behavior changes in children after general anesthesia. Paediatric Anaesthesia 16: 846–859 (2006)
Stargatt R, Rosenfeld JV, Anderson V, Hassall T, Maixner W and Ashley D. Intelligence and adaptive function in children diagnosed with brain tumour during infancy. Journal of NeuroOncology 80: 295–303 (2006)
Steer AC, Starr M and Kornberg AJ. Bickerstaff brainstem encephalitis associated with Mycoplasma pneumoniae infection. Journal of Child Neurology 21: 533–534 (2006)
Steinmann K and Babl FE. Antibiotic prescribing rates for acute otitis media in a paediatric emergency department. Journal of Paediatrics & Child Health 42: 204–205 (2006)
Stevens MP, Garland SM and Tabrizi SN. Human papillomavirus genotyping using a modified linear array detection protocol. Journal of Virological Methods 135: 124–126 (2006)
Stevens MP, Rudland E, Garland SM and Tabrizi SN. Assessment of MagNA pure LC extraction system for detection of human papillomavirus (HPV) DNA in PreservCyt samples by the Roche AMPLICOR and LINEAR ARRAY HPV tests. Journal of Clinical Microbiology 44: 2428–2433 (2006)
Stevens MP, Tabrizi SN, Quinn MA and Garland SM. Human papillomavirus genotype prevalence in cervical biopsies from women diagnosed with cervical intraepithelial neoplasia or cervical cancer in Melbourne, Australia. International Journal of Gynecological Cancer 16: 1017–1024 (2006)
Stewart C, Spicer M and Babl FE. Caring for adolescents with mental health problems: Challenges in the emergency department. Journal of Paediatrics & Child Health 42: 726–730 (2006)
Stewart MC, Fosang AJ, Bai Y, Osborn B, Plaas A and Sandy JD. ADAMTS5–mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. Osteoarthritis & Cartilage 14: 392–402 (2006)
Stocker CF and Shekerdemian LS. Recent developments in the perioperative management of the paediatric cardiac patient. Current Opinions in Anaesthesiology 19: 375–381 (2006)
Sudarsha, CD, Cochrane AD, Jun ZH, Soto R and Brizard, CP. Repair of coarctation of the aorta in infants weighing less than 2 kilograms. Annals of Thoracic Surgery 82: 158–163 (2006)
Sumer EU, Sondergaard BC, Rousseau JC, Delmas PD, Fosang AJ, Karsdal MA, Christiansen C and Qvist P. MMP and non MMP mediated release of aggrecan and its fragments from articular cartilage: A comparative study of three different aggrecan and glycosaminoglycan assays (advanced online publication). Osteoarthritis & Cartilage (2006)
Sundararajan V, Korman T, Macisaac C, Presneill JJ, Cade JF and Visvanathan K. The microbiology and outcome of sepsis in Victoria, Australia. Epidemiology & Infection 134: 307–314 (2006)
Szoeke CEI, Newton M, Wood JM, Goldstein D, Berkovic SF, OBrien TJ and Sheffield LJ. Update on pharmacogenetics in epilepsy: A brief review. Lancet Neurology 5: 189–196 (2006)
Tabrizi SN, Fairley CK, Bradshaw CS and Garland SM. Prevalence of Gardnerella vaginalis and Atopobium vaginae in virginal women. Sexually Transmitted Disease 33: 663–665 (2006)
Tan NCK, Mulley JC and Scheffer IE. Genetic dissection of the common epilepsies. Current Opinion in Neurology 19: 157–163 (2006)
Tan TY and Amor DJ. Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: A novel syndrome. American Journal of Medical Genetics Part A 143: 114–118 (2006)
Tan TY and Amor, DJ. Tumour surveillance in Beckwith Wiedemann syndrome and hemihyperplasia: A critical review of the evidence and suggested guidelines for local practice Journal of Paediatrics & Child Health 42: 486–490 (2006)
Tan TY, Amor DJ and Chow CW. Juvenile papillomatosis of the breast associated with neurofibromatosis 1 (advanced online publication). Pediatric Blood & Cancer (2006)
Tan TY, Nazaretian S, McGillivray G, Simpson I and Bankier A. Distinctive collection of fetal anomalies: Cleft lip and palate, multicystic dysplastic kidneys, 1–2 syndactyly, heterotopic olivary tissue and thymic hypoplasia. Clinical Dysmorphology 15: 101–105 (2006)
Tang ML, Wilson JW, Stewart AG and Royce SG. Airway remodelling in asthma: current understanding and implications for future therapies. Pharmacology & Therapeutics 112: 474–488 (2006)
Tassicker, RJ, Marshall, PK, Liebeck, TA, Keville, MA, Singaram, BM and Richards, FH. Predictive and pre-natal testing for Huntington Disease in Australia: results and challenges encountered during a 10-year period (1994–2003). Clinical Genetics 70:6 480–489 (2006)
Teichtahl AJ, Morris ME, Wluka AE, Baker R, Wolfe R, Davi, SR and Cicuttini FM. Foot rotation: A potential target to modify the knee adduction moment. Journal of Science & Medicine in Sport 9: 67–71 (2006)
Thomas C, Mitchell P, O’Rourke P and Wainwright C. Quality of life in children and adolescents with cystic fibrosis managed in both regional outreach and cystic fibrosis center settings in Queensland. Journal of Pediatrics 148: 508–516 (2006)
Thomas DM, Seymour JF, O’Brien T, Sawyer SM and Ashley DM. Adolescent and young adult cancer: a revolution in evolution? Internal Medicine Journal 36: 302–307 (2006)
Thompson DK, Warfield SK, Carlin JB, Pavlovic M, Wang HX, Bear M, Kean MJ, Doyle LW, Egan GF and Inder TE. Perinatal risk factors altering regional brain structure in the preterm infant (advanced online publication) Brain (2006)
Thornton V, Lennon D, Rasanathan K, O’Hallahan J, Oster P, Stewart J, Tilman S, Aaberge I, Feiring B, Nokleby H, Rosenqvist E, White K, Reid S, Mulholland K, Wakefield MJ and Martin D. Safety and immunogenicity of New Zealand strain meningococcal serogroup B OMV vaccine in healthy adults: beginning of epidemic control. Vaccine 24: 1395–1400 (2006)
Thuys C, Horton S, Bennett M and Augustin S. New technology increases perioperative haemoglobin levels for paediatric cardiopulmonary bypass: what is the benefit? Perfusion 21: 39–44 (2006)
Tibballs J and Kinney S. A prospective study of outcome of in-patient paediatric cardiopulmonary arrest. Resuscitation 71: 310–318 (2006)
Tibballs J, Cathie R, Buist M, Shimizu K, Stokes K and Millar J. Upper airway obstruction caused by ingestion of concentrated acetic acid. Anaesthesia & Intensive Care 34: 379–381 (2006)
Tibballs J, Fasulakis S, Robertson CF, Berkowitz RG, Massie J, Brizard C, Rose E, Bekhit E, Eyres R and Ragg P. Polyflextrade mark stenting of tracheomalacia after surgery for congenital tracheal stenosis. International Journal of Pediatric Otorhinolaryngology 71: 159–163 (2006)
Tibballs J, Robertson C and Wall R. Tracheal ulceration and obstruction associated with flexible Bivona tracheostomy tubes. Anaesthesia & Intensive Care 34: 495–497 (2006)
Tibballs J. Australian Resuscitation Council: Paediatric advanced life support (PALS) guidelines. Critical Care Resuscitation 8: 132–134 (2006)
Tibballs J. Australian venomous jellyfish, envenomation syndromes, toxins and therapy. Toxicon 48: 830–859 (2006)
Tibballs J. The legal basis for ethical withholding and withdrawing of life sustaining medical treatment in children. Journal of Law & Medicine 14: 244–261 (2006)
Tibballs J. Withdrawal of futile treatment from children: Implications of NHS Trust versus MB. Journal of Paediatrics & Child Health 42: 563–564 (2006)
Trembath MK, Tassicker RJ, Collins VR, Mansie S, Sheffield LJ and Delatycki MB. Fifteen years of experience in predictive testing for Huntington disease at a single testing center in Victoria, Australia. Genetics in Medicine 8: 673–680 (2006)
Tubridy-Clark M and Carapetis JR. Subclinical carditis in rheumatic fever: A systematic review (advanced online publication). International Journal of Cardiology (2006) Tweddle EA and Berkowitz RG. Adolescent otolaryngology. International Journal of Pediatric Otorhinolaryngology 70: 609–612 (2006)
Ukoumunne OC, Carlin JB and Gulliford MC. A simulation study of odds ratio estimation for binary outcomes from cluster randomized trials (advanced online publication). Statistics in Medicine (2006)
Vadlamudi L, Kheldsen MJ, Corey LA, Solaas MH, Friis ML, Pellock JM, Nakken KO, Milne RL, Scheffer IE, Harvey AS and Hopper J L. Analyzing the etiology of benign rolandic epilepsy: A multicenter twin collaboration. Epilepsia 47: 550–555 (2006)
Vadolas J, Nefedov M, Wardan H, Mansooriderakshan S, Voullaire L, Jamsai D, Williamson R and Ioannou PA. Humanized beta thalassemia mouse model containing the common IVSI-110 splicing mutation. Journal of Biological Chemistry 281: 7399–7405 (2006)
Vallino-Napoli LD, Riley MM and Halliday JL. An epidemiologic study of orofacial clefts with other birth defects in Victoria, Australia Cleft Palate — Craniofacial Journal 43: 571–576 (2006)
van der Mei IAF, Blizzard L, Ponsonby AL and Dwyer T. Validity and reliability of adult recall of past sun exposure in a case control study of multiple sclerosis. Cancer Epidemiology Biomarkers & Prevention 15: 1538–1544 (2006)
van Werkhoven MA, Thorburn DR, Gedeon AK and Pitt JJ. Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome. Journal of Lipid Research 47: 2346–2351 (2006)
Vance A, Arduca Y, Sanders M, Karamitsios M, Hall N and Hetrick S. Attention deficit hyperactivity disorder, combined type, dysthymic disorder and anxiety disorders: Differential patterns of neurodevelopmental deficits. Psychiatry Research 143: 213–222 (2006)
Vance A, Hall N, Bellgrove MA, Casey M, Karsz F and Maruff P. Visuospatial working memory deficits in adolescent onset schizophrenia. Schizophrenia Research 87: 223–227 (2006)
Verhagen AM, Kratina TK, Hawkins CJ, Silke J, Ekert PG and Vaux DL. Identification of mammalian mitochondrial proteins that interact with IAPs via N terminal IAP binding motifs (advanced online publication). Cell Death & Differentiation (2006)
Waddell N, Jonnalagadda J, Marsh A, Grist S, Jenkins M, Hobson K, Taylor M, Lindeman GJ, Tavtigian SV, Suthers G, KconFab Investigators and others. Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling. Genes, Chromosomes and Cancer 45: 1169–1181 (2006)
Wake M, Hardy P, Canterford L, Sawyer M and Carlin J. Overweight, obesity and girth of Australian preschoolers: Prevalence and socioeconomic correlates (advance online publication). International Journal of Obesity (2006)
Wake M, Morton-Allen E, Poulakis Z, Hiscock H, Gallagher S and Oberklaid F. Prevalence, stability, and outcomes of cryfuss and sleep problems in the first 2 years of life: prospective community based study. Pediatrics 117: 836–842 (2006)
Wake M, Tobin S, Cone-Wesson B, Dahl HH, Gillam L, McCormick L, Poulakis Z, Rickards FW, Saunders K, Ukoumunne OC and Williams J. Slight/mild sensorineural hearing loss in children. Pediatrics 118: 1842–1851 (2006)
Wandi F, Peel D and Duke T. Hypoxaemia among children in rural hospitals in Papua New Guinea: Epidemiology and resource availability — a study to support a national oxygen programme. Annals of Tropical Paediatrics 26: 27–284 (2006)
Wang, YHJ, Andrews, RM and Lambert, SB. Measles surveillance in Victoria, Australia. Bulletin of the World Health Organization 84: 105–111 (2006)
Ward RL, Kirkwood CD, Sander DS, Smith VE, Shao M, Bean JA, Sack DA and Bernstein DI. Reductions in cross neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89–12. Journal of Infectious Diseases 194: 1729–1736 (2006)
Ward,BK, Cameron FJ, Magno AL, McDonnell CM, Stuckey BGA and Ratajczak T. A novel homozygous deletion in the calcium-sensing receptor ligand binding domain associated with neonatal severe hyperparathyroidism. Journal of Pediatric Endocrinology & Metabolism 19: 93–100 (2006)
Walterfang, M, O’Donovan, J, Fahey, M and Velakoulis, D. Psychiatric Morbidity in Adrenomyeloneuropathy. Australian and New Zealand Journal of Psychiatry 40: suppl.1: (June 2006)
Waters E, Doyle J, Jackson N, Howes F, Brunton G and Oakley A. Evaluating the effectiveness of public health interventions: the role and activities of the Cochrane Collaboration. Journal of Epidemiology & Community Health 60: 285–289 (2006)
Watkins WJ, Harris SE, Craven MJ, Vincent AL, Winship IM, Gersak K and Shelling AN. An investigation into FOXE1 polyalanine tract length in premature ovarian failure. Molecular Human Reproduction 12: 145–149 (2006)
Webby RJ, Bines JE, Barnes GL, Tindall H, Krause V and Patel, M. Intussusception in the northern territory: The incidence is low in aboriginal and torres strait islander children. Journal of Paediatrics & Child Health 42: 235–239 (2006)
Wei BP, Robins-Browne RM, Shepherd RK, Azzopardi K, Clark GM and O’Leary SJ. Protective effects of local administration of ciprofloxacin on the risk of pneumococcal meningitis after cochlear implantation. Laryngoscope 116: 2138–2144 (2006)
Wei BP, Shepherd RK, Robins-Browne RM, Clark GM and O’Leary SJ. Pneumococcal meningitis threshold model: A potential tool to assess infectious risk of new or existing inner ear surgical interventions. Otology & Neurotology 27: 1152–1161 (2006)
Wei BPC, Shepherd RK, Robins-Browne RM, Clarke GM and O’Leary SJ. Pneumococcal Meningitis: Development of a New Animal Model. Otology & Neurotology 27: 844–854 (2006)
Wertheim E, Freeman M, Trinder M and Sanson A. Lessons drawn from the enhancing relationships in school communities project. The Australian Community Psychologist 18: 71–81 (2006)
White SM. Talking genes. Advances in Speech-Language Pathology 8: 2–6 (2006)
Wilkinson DJ, Baikie G, Berkowitz RG and Reddihough DS. Awake upper airway obstruction in children with spastic quadriplegic cerebral palsy. Journal of Paediatrics & Child Health 42: 44–48 (2006)
Wilkinson DJ, Buttery JP and Andersen CC. Influenza in the neonatal intensive care unit. Journal of Perinatology 26: 772–776 (2006)
Wilkinson DJ, Fitzsimons JJ, Dargaville PA, Campbell NT, Loughnan PM, McDougall PN and Mills JF. Death in the neonatal intensive care unit: Changing patterns of end of life care over two decades. Archives of Disease in Childhood — Fetal & Neonatal Edition 91: 0–0 (2006)
Wilkinson-Berka JL, Wraight C and Werther G. The role of growth hormone, insulin like growth factor and somatostatin in diabetic retinopathy. Current Medicinal Chemistry 13: 3307–3317 (2006)
William V, Burrow MF, Palamara JEA and Messer LB. Microshear bond strength of resin composite to teeth affected by molar hypomineralization using 2 adhesive systems. Pediatric Dentistry 28: 233–241 (2006)
William V, Messer LB and Burrow MF. Molar incisor hypomineralization: Review and recommendations for clinical management Pediatric Dentistry 28: 224–232 (2006)
Wong FY, Mitchell PJ, Tress BM, Dargaville PA and Loughnan PM. Hemodynamic disturbances associated with endovascular embolization in newborn infants with vein of Galen malformation. Journal of Perinatology 26: 273–278 (2006)
Wong NC, Wong LH, Quach JM, Canham P, Craig JM, Song JZ, Clark SJ and Choo KH. Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation. PLoS Genetics 2: 0– (2006)
Woodward LJ, Anderson PJ, Austin NC, Howard K and Inder TE. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. New England Journal of Medicine 355: 685–694 (2006)
Wu K, Anderson V and Castiello U. Attention deficit/ hyperactivity disorder and working memory: A task switching paradigm. Journal of Clinical & Experimental Neuropsychology 28: 1288–1306 (2006)
Yang J, Baldi DL, Tauschek M, Strugnell RA and RobinsBrowne RM. Transcriptional regulation of the yghJ-pppAyghG-gspCDEFGHIJKLM cluster encoding the type II secretion pathway in enterotoxigenic E. coli. (advanced online publication) Journal of Bacteriology (2006)
Young HM, Newgreen DF and Burns AJ. The development of the enteric nervous system in relation to Hirschsprung’s disease. In: Ferretti P, Copp A, Tickle C and Moore G (eds). Embryos, Genes and Birth Defects. John Wiley and Sons (2006)
Zain Z, Zadinello M, Menahem S and Brizard C. Neonatal isolated critical aortic valve stenosis: Balloon valvuloplasty or surgical valvotomy. Heart, Lung & Circulation 15: 18–23 (2006)
Zhao YC and Berkowitz, RG. Prolonged hospitalization following tonsillectomy in healthy children. International Journal of Pediatric Otorhinolaryngology 70: 1885–1889 (2006)
Murdoch Childrens Research Institute and its controlled entities
i ncome Statement for the year ended 31 d ecember 2006
Murdoch Childrens Research Institute and its controlled entities
balance Sheet aS at 31 december 2006
Murdoch Childrens Research Institute and its controlled entities
Statement of caSh flowS for the year ended 31 december 2006
staFF and students
2005 TOTAL STAFF AND STUDENTS: 745 (+12% from 2005)
STAFF: 600 (+12% from 2005)
STUDENTS: 66 (+9% from 2005)
The policy team is responsible for the development and implementation of policies and strategies that support and advance the research goals of the institute.
In 2006 working closely with the Director and theme directors, the policy team launched a unique institute wide research performance evaluation process. Comprehensive data linked to key performance areas was collected from the six research themes. In keeping with the institute’s mission the key areas included knowledge generation (publications), research contribution (competitive funding), clinical and public health outcomes.
The performance evaluation committee assessed the performance data, research development and innovation, to calculate the allocation of internal funding to each theme. A valuable outcome of the evaluation process was the feedback provided to themes about the areas of research performance that required attention. Thanks to all who contributed to the performance evaluation process, which will be conducted annually in the future.
The policy team led the development of a policy for the allocation of research space on the RCH campus, which is currently limited (or at capacity).
The key principle of the policy is that the allocation of research space is based on research performance and allows the institute to continue to conduct globally competitive research. The policy is being utilised by the space committee, chaired by the Chief Operating Officer, which is responsible for making recommendations on the strategic allocation of research space to existing or new research groups.
Another important focus for the policy team was the advocacy campaign seeking funding for additional research space in the new RCH development. Public affairs consultants Gavin Anderson & Co were appointed to assist with the campaign in August 2006. We thank Allan Scroope and his team for an outstanding contribution.
The campaign involved MCRI Chairman Laurence Cox, Director Professor Terry Dwyer and Policy Advisor Moira Clay meeting with Cabinet Ministers, backbench MPs and their advisors in Canberra and Melbourne, in addition to countless hours dedicated to preparing MCRI’s business case for funding. The response has been positive and MCRI has gained valuable experience interacting with senior bureaucrats in government departments. The board has sought assistance from leaders in the business community to support MCRI’s cause. The
advocacy campaign will continue in 2007, permitting a seamless transition into the next stage of the institute’s strategic growth and development.
Finally, the policy team has worked closely with the executive committee in a number of strategic planning exercises throughout the year. The most recent workshop focused on mentoring of researchers and support staff. An innovative career mentoring program is now in development, to be rolled out in 2007.
Growth and development of the Institute continued to increase demand on corporate services staff in 2006.
With more grant applications submitted and greater success in grants and contracts awarded there was an increased need for support from all areas.
• Initiated a major project to upgrade and renovate MCRI accommodation on the RCH campus
• Commenced a review of all the non-research activities of the Institute to determine where change is needed to support anticipated growth of the institute in the future
• Revamped and significantly expanded the individual Performance Evaluation Program to more closely align individual performance with MCRI goals
• Recognised for the fourth consecutive year as an “Employer of Choice for Women”
Continued growth of the Institute in 2006 saw a 40% increase in the number of grant applications submitted by MCRI researchers. This increase contributed to a rise in grants awarded as more of our researchers gained external funding. One benefit in particular is the award of $14million in National Health and Medical Research Council grants and fellowships commencing in 2007.
Myles Gaffney was appointed to the grants team mid-year in a full time position, to assist with increased requests and support required for researchers on campus. An important role for Myles is the sourcing of new avenues of funding, both national and international.
In collaboration with the human resources department a student support system was developed for the MCRI/RCH campus. One component is “Top Ups”, which are competitive awards in addition to scholarships, designed to assist high-achieving students as they continue their studies. An individual award of $7500 per annum is named in recognition of the Institute’s first Director, Professor David Danks.
In mid 2006, the Institute commenced a major undertaking to upgrade and renovate accommodation on the RCH campus. This was made possible by a Commonwealth Government infrastructure grant of $10million. The aim of the funding was to assist MCRI develop onsite capital assets and alleviate the existing and future operational pressures caused by the growth of the Institute.
• The office refurbishment for epigenetics on the 9th floor was the first project completed under this program. This project provided the newly formed group with much needed office space for its senior researchers, research assistants and students
• Upgrades to laboratories on the 9th floor main building allowed the relocation of groups and initiated the establishment of an MCRI core histology facility
• Significant renovation of laboratories and offices on the 3rd floor commenced. Lack of MCRI office space on the 3rd floor was helped by the conversion of a large, ageing laboratory into office accommodation. This area will address the work requirements for the Early Development and Disease and Musculoskeletal Disorders themes
• The information technology group was moved into newly renovated office accommodation. The area that once served as an onsite library was refurbished to allow the consolidation of this group into a single location adjacent to MCRI operations. The office space freed up in
the move will go towards the establishment of a dedicated VCGS Pathology specimen reception area and allowed the upgrade of the MCRI server room which in the past struggled to cope with increased demands caused by the growth of the Institute.
Human resources were kept busy in 2006 with extensive recruitment of new researchers and the continued development of policies and processes to provide greater clarity and consistency for all staff in their working lives.
The individual performance evaluation program was also revamped and expanded significantly. This helped to more closely align individual performance with organisational goals of greater research productivity, and increased knowledge in the area of child health.
New training initiatives were introduced and will continue as HR broadens its role of providing learning and development programs to all staff.
As the Institute grows, there is continued demand for increased network storage space. As a consequence, IT expanded the amount of space available and installed a power backup supply with a comfortable margin in the event of a power failure.
Wireless network technology provided staff with an alternative means of network connectivity. With minimal up front investment, this allowed the institute to cater for the growing network requirements of research groups. We thank the RCH IT department for its assistance and support in this area.
Considerable effort went into improving support for databases. One feature allows access to stored data via web browsers. Through web-accessible forms this will be a common way of providing information to researchers.
MCRI was proud to be recognised by the Equal Opportunity for Women Agency for the fourth consecutive year as an “Employer of Choice for Women”. This continued achievement reflects the Institute’s success in leading and managing diversity, our work life balance initiatives and many of our staff management practices. Only 131 Australian employers (and 39 in Victoria) have been awarded this status.
Internet technology was used to gather data for research projects during 2006. The IT department assisted one of the Institute’s research groups in a successful trial where a questionnaire was delivered via mobile phone and responses captured via SMS. In future, this may prove to be an effective way to capture real time data.
1. Chief Operating Officer, Anne Cronin 2. Finance Manager, Viren Abeyasinghe 3. Human Resources Manager, Kathryn Bellion 4. Grants Management, Julia Malone 5. Building and Development, Ross McKenzie 6. Occupational Health and Safety, Yvette Muller 7. Information Technology Manager, George Teng 8. Payroll Manager, Debbie Zombolas
There was a further increase to the patent portfolio and a number of new initiatives to assist in the commercialisation of MCRI’s world class research in 2006.
Nine new international patent applications were filed to support the research and commercial partnership with the Victorian Infectious Diseases Reference Laboratory (VIDRL). This is in addition to the six international patent applications previously submitted, which make up an impressive portfolio of 15 international patent applications.
An exclusive option agreement for the hepatitis B virus diagnostic and therapeutic technology was signed in late 2006. Melbourne Health has now taken the commercial lead for this technology due to its expertise in the field of hepatitis and commercial contacts in this area.
Let’s Read is a collaboration established between the Centre of Community and Child Health at MCRI and the Smith Family. It is a nationwide program promoting literacy in children between from birth to five years of age. A license agreement to access the program has been signed in 34 centres in Australia.
POSSUM is a software tool to diagnose syndromes in patients and can also be used as a useful teaching tool, as it contains information on more than 3000 syndromes, including chromosomal and skeletal syndromes. Since its conception more than 600 licenses to POSSUM have been sold worldwide. POSSUM Web was officially launched at the International Congress of Human Genetics in Brisbane in 2006. The new web product was evaluated by more than 40 users in more than 20 countries and is due for release in April 2007.
MCRI was a founding partner and a leading Shareholder in Antisense Therapeutics Limited (ATL) – ASX code: ANP. ATL is an Australian publicly traded pharmaceutical drug discovery and development company. In 2006 the company commenced a phase IIa trial for its product for the treatment of Multiple Sclerosis. Further information on this company can be found at www.antisense.com.au.
The success of POSSUM continues with more than 600 licences now sold worldwide. An additional 35 license agreements were signed in 2006. This includes 34 license agreements for the Let’s Read program and a license agreement with Millipore for unique antibody reagents.
MCRI filed a total of 13 patent applications in 2006. These include:
• Three invention disclosures submitted with two new provisional patents being submitted; one relating to a new rotavirus vaccine and the second to a new technology for the detection of Down syndrome
• Two provisional applications converted into international applications in the areas of cancer and arthritis
• Nine international patent applications filed in the area of hepatitis B treatment
The following initiatives were introduced to assist in developing commercial activities at MCRI:
• A license agreement with Nerac in USA for its patent-searching services to assist in the identification of prior art
• License agreement with LEX in Australia for a patent database management system
• A patent attorney was appointed one day per week for three months to assist with the patent portfolio
• Business development manager position was created to commence in 2007
• A license agreement with the intermediary service InnovationXChange (IXC) to increase access to commercial networks
• A commercialisation course run by CIS Consulting and Implementation Services was attended by 10 senior scientists to assist their understanding of the commercialisation process. Dr Jim Vadolas who attended this course was successful in obtaining an NHMRC development grant for the identification of novel therapeutic agents for the treatment of thalassemia as well as other anaemic disorders. This development grant will assist in advancing his work into a commercial venture in the future.
Anne Cronin Chief Operating Officer
The scientific services team provided specific expertise and training in laboratory support, tissue culture and disease models.
Laboratory support is responsible for management of biological and radioactive waste, preparation and sterilisation of glassware and solutions, maintenance of equipment and the supply of common reagents and plastic ware.
The tissue culture laboratory provided cell cultures and media for research as well as establishing skin fibroblast or lymphoblast cultures from patients for diagnostic testing. In March, the institute welcomed John Waddington as the new head of tissue culture to replace our long-time tissue culture expert Marjorie Crawford. During 2006, two state-of-the-art vapour phase liquid nitrogen tanks were commissioned, which enabled the transfer of more than 30,000 ampoules of cells into new tanks and the removal of liquid nitrogen from the main block building at RCH. This process was underpinned by the development of a secure database by MCRI IT, who worked with members of the tissue culture laboratory and researchers.
The disease model unit takes care of approximately 50 strains of genetically modified mice for researchers studying diseases such as thalassemia, arthritis, asthma and complex 1 deficiency. Many of the staff members in the unit have joint appointments with MCRI research groups that use mice, which helps the research groups minimise the use of laboratory mice as well as manage the regulatory reporting of mouse usage to the MCRI animal ethics committee, Bureau of Animal Welfare Victoria and National Health & Medical Research Council.
In September, Dr Kerry Fowler attended the Australian and New Zealand Society for Laboratory Animal Scientists meeting in Canberra, presenting the unit’s results on the use of isoflurane anaesthesia for mice and the development of an improved cage lid with the commercial company RE Walters.
With collaborators George Teng and Stanley Ho, Dr Fowler was awarded the 2006 Murdoch Childrens Research Institute Innovation Award for work developing two web-based computer programs for the mandatory tracking and reporting of animals used in medical research.
The flow cytometry and confocal microscopy facility provides specialised, high-performance instrumentation and support for analysis, cell sorting and imaging facilities to both internal and external researchers.
The facility moved to a new laboratory in 2006, providing researchers with a single centralised resource for their cytometry and imaging requirements. Equipped with an LSR II analytical flow cytometer, Leica TCS SP2 confocal microscope and MoFlo cell sorter, the facility contributed to many research projects and groups throughout the institute. The recently acquired cell sorter allows for the isolation and purification of specific chromosomes from cells, a service no other laboratory within Australia currently provides.
1. Dr Kerry Fowler
2. Dr Matt Burton
3. John Waddington
Staff
CHIEF OPERATING OFFICER
Anne Cronin
Colleen King Personal Assistant to COO
BUILDING AND SCIENTIFIC SERVICES
Andrew Grimes Technical Services Manager
Dr Ross McKenzie Business and Building Development Officer
Yvette Mueller
OH&S Coordinator
Mandy Parkinson Bates
Assistant Operations Officer
Robert Kimoski Purchasing Officer
FINANCE
Viren Abeyasinghe Finance Manager
Neil Harker
Finance Consultant
Geraldine Allen Accountant
Joanne Le Accountant
Maria Telford Accountant
Neofita Hajigeorgi
Administrative Assistant
Maggie Fu Patient Accounts
Christine Keenan
Patient Accounts
Caroline Schram
Patient Accounts
GRANTS
Julia Malone
Grants Officer
Myles Gaffney
Grants
Administrative Assistant
GRAPHIC DESIGN
Voula Boukouvalas
Photographer / Graphic Artist
Michele Winsor
Photographer / Graphic Artist
HUMAN RESOURCES
Kathryn Bellion
Human Resources Manager
Andrea Frigo
Human Resources Officer
Nicki Hockley
Human Resources Officer
INFORMATION TECHNOLOGY
George Teng
IT Manager
Joe Nuchthapho
Network Officer
Jason Elliott
Web Administrator
Michael Mariani
Network Officer
Jim Ristevski
Support Officer
Shilpa Shah
Support Officer
Michael Black
Computer Programmer
Stanley Ho
Computer Programmer
PAYROLL
Debbie Zombolas
Payroll Manager
Sandra Nield
Senior Payroll Officer
Sharon Dughetti Payroll Officer
RECEPTION / SECRETARIAL SERVICES
Jacqueline Beach
Administrative Assistant
Jo Buckle
Research Affiliate
Vicki Hirt
Receptionist /
Library Assistant
Sarah Lacey
Personal Assistant
Jan Morrison
Executive Assistant to Director
Helen Raschella
Administrative Assistant
DISEASE MODELS
Dr Kerry Fowler
Group Leader
Sophie Gazeas
Senior Technical Officer
Amanda Blaik
Technical Assistant
Anna Cawood
Technical Assistant
Shelley McCaig
Technical Assistant
Lana Ninkovic
Technical Assistant
Amy Pope
Technical Assistant
Meagan Thornton
Technical Assistant
Carly Turner
Technical Assistant
Frances Voth
Technical Assistant
FLOW CYTOMETRY & CONFOCAL
MICROSCOPY
Dr Matt Burton
Flow Cytometry Manager
LABORATORY
SUPPORT
Dino Disint
Technical Assistant
Sophie Kotsakidis
Technical Assistant
Paul Lau
Technical Assistant
Zahra Manji
Technical Assistant
Tom Milovac
Technical Officer
TISSUE CULTURE
John Waddington
Group Leader
Anna Czajko
Technical Assistant
Mark Edmunds
Technical Assistant
Josefina (Lucy)
Perez
Technical Officer
Murdoch Childrens Research Institute PR & Development team raised income from foundations, corporate supporters, fundraising events, bequests and private donors to support the institute’s independence and ability to strategically invest in research.
• Integrate and consolidate fundraising and communication activities
• Invest in infrastructure and human resources to build more diverse development programs
• Increase support from corporate sector including The PUMA Lap
• Consolidate brand to build awareness and increase emotional engagement of supporters
• Develop and implement advertising campaign
Donor relations
A key strategy was to engage a new generation of friends and supporters and leverage pro bono support, while maintaining relationships with current supporters and consolidating development programs. Support and expertise donated by the development board and committees was essential
for success. Our database of loyal supporters increased from 3000 in 2005 to 4500 in 2006. New donor database software allowed us to better capture and track donation information.
Through integration of fundraising with communications, recruitment of additional staff and policy development, we increased fundraising income from donations and events from $2.5million to $2.6million in 2006. The PUMA Lap corporate challenge was particularly successful with more than 1200 corporate staff from 60 organisations raising $430,000.
Despite the success of our events, donation income had slowed in the third quarter of 2006 so a new Christmas campaign was created. Promoted by Dame Elisabeth Murdoch AC DBE, the campaign was highly successful. Bequest income was $1.67million in 2005 and $1.43million in 2006, boosted in both years by the estate of Joan Roxburgh.
We identified opportunities in corporate partnerships and corporate philanthropy and engaged causerelated marketing experts Cavill + Co to commence a 12 month strategy to secure major partners in 2007.
The development board’s purpose was reviewed and terms of reference developed. Antony Catalano, Aimee Dean Pritchard, Jane Fenton, Alex Lowen, Jason Newman and Ryan O’Hare resigned after three years of valuable service. We recruited Tony Davies from Citigroup Private Bank, Ben James from UBS Wealth Management and Ion Teska from Teska Carson. Cruden Farm family day, the Heritage Charity Golf Day and The PUMA Lap were all supported by the development board and committees. Our ambassador Sarah Murdoch once again demonstrated her commitment to the institute through invaluable personal support, hosting lunches to encourage corporate participation in The PUMA Lap corporate challenge and launching the event in Sydney.
Working with creative agency Hub Group, all MCRI communications, including e-bulletins, brochures, newsletters, annual report, DVD, and advertisements were redesigned as part of the new brand strategy. We secured pro bono market research from Sweeney Research to measure community awareness and attitudes towards MCRI to inform future strategy development.
News Limited continued to generously support MCRI by $1million worth of ad space in The Australian. We also received pro bono ad space in the Herald Sun and The Age. Advertising targeted to corporate audiences was supported by Inlink and Qantas.
Through media relations activities, we achieved 300 media stories and further positioned MCRI as a national leader on child health issues. Fifty staff underwent intensive media training. Media highlights included coverage about childhood obesity research, a new genetic test for cystic fibrosis risk, the bird flu vaccine trial, the launch of the Children’s MRI Centre and a feature on new epigenetics research.
To improve internal communications following the MCRI restructure, new e-bulletins, monthly director’s reports and quarterly director’s forums were introduced. A new staff achievement awards scheme was also introduced.
• To increase fundraising income from donations and events to $3.6million
• To complete work with Cavill + Co to secure major brand driven corporate partnerships
• To build income and new supporters through events
• To increase support from corporate philanthropy, pro bono support and workplace giving
• To complete the website redevelopment and to develop a new online donation facility
• To develop a e-communications program to engage a new generation of supporters
• To further develop direct mail campaigns, through better use of donor segmentation
• To increase pro bono advertising to raise MCRI’s profile nationally
Dr Narelle Curtis
PR & Development Manager
1. Chair, Mrs Suzi Carp
2. Deputy Chair, Mr Angus Reynolds
3. Mrs Prue Brown
4. Mrs Susannah Calvert-Jones
5. Dr Narelle Curtis
6. Mr Tony Davies
7. Mr Ben James
8. Mr Fraser Macvean
9. Mrs Sarah Murdoch
10. Mr Sam Patterson
11. Mr Ion Teska Staff list
Dr Narelle Curtis
PR & Development Manager
Rebecca Harford
Development Officer (from March 2006)
Alyssa Jones
Communications Coordinator
Daniela Moreira
Administrative Assistant
Aaron Begg
PR Assistant / Volunteer
Michelle Goldstein
Volunteer
Lisa Purnell
PR Assistant / Volunteer
Murdoch Childrens
Research Institute has many
loyal supporters, including major private donors, trusts and foundations and corporate supporters
The Royal Children’s Hospital and the University of Melbourne Department of Paediatrics are committed to working with MCRI to provide world class care and medical research to better prevent and treat conditions affecting children.
The Good Friday Appeal continued its long standing success in 2006, raising more than $10 million.
A substantial portion of the funds raised by the appeal was directed to MCRI research, allowing us to continue our work to improve the health and wellbeing of children.
The Federal government awarded funding through the National Health & Medical Research Council, Australian Research Council, Department of Health & Ageing and Department of Family and Community Services. This included a $10 million grant for capital development. State funding was received through Department of Innovation, Industry & Regional Development, Department of Human Services and VicHealth.
Our research was again generously supported by many charitable organisations including:
ANZ Medical Trusts, Australian Cancer Research Foundation, Australian Rotary Health Research Fund, Burge Trust, Colonial Foundation, CP Foundation, Diabetes Australia Research Trust, Friedreich’s Ataxia Research Alliance, Garnett Passe & Rodney Williams Memorial Foundation, Heart Foundation, Helen Macpherson Smith Trust, Hugh Williamson Foundation, Ilhan Foundation, Jack Brockhoff Foundation, Marian & EH Flack Trust, Miller Foundation, Perpetual Trustees, Pratt Foundation, RE Ross Trust, Rotary Inner Wheel Australia, Telstra Foundation, Victor Smorgon Charitable Foundation and Windermere Foundation.
Major funding was won competitively from international sources including the Juvenile Diabetes Research Foundation International, March of Dimes Birth Defects Foundation, Muscular Dystrophy Association (US), National Childhood Cancer Foundation, National Institutes of Health USA, Nutricia Research Foundation, Paediatric Brain Tumor Foundation of the United States, World Health Organization and World Heart Federation.
Our patron Dame Elisabeth Murdoch and her family continued their ongoing generous and personal support. Dame Elisabeth once again opened her gardens to 2000 friends of the institute for our second annual family day at Cruden Farm.
Dame Elisabeth’s daughter Janet Calvert-Jones and grand-daughter Judy Paterson continued to serve on the board. Janet’s daughter in law Susannah CalvertJones served on the development board.
We continued to receive support from corporate organisations through donations, event sponsorship and considerable in kind support. We greatly appreciate continued support from ABN AMRO,
The Age, ANZ Client & Relationship Group & Private Bank, AON, Austereo Network, Australian Medical Insurance Limited, Axum International Trading, Bexton Personnel, BHP Billiton, Bridge Real Estate, CHE/ OMD, Clayton Utz, Colliers International, Deacons lawyers, Deloitte, Eclipse, Elite Fitness Equipment, Ernst & Young, Fenton Communications, FOXTEL, Hub Group, HBOS, The Herald & Weekly Times, Hicksons Lawyers, Howarth, Inlink Media, Investec Bank Limited, Kay & Burton, KordaMentha, KPMG, Minter Ellison, National Australia Bank, News Custom Publishing, News Limited, PUMA, PKF, PUMA, Qantas, Ross Human Directions, River Capital, Russell Investment Group, SAI, SalesForce, Splitrock, St George Bank Limited, The Swann Group, Suncorp, Sweeney Research, Telstra, Village Roadshow Limited and William Buck.
1 Judy Paterson, Martin Delatycki, Terry Dwyer and Susannah Calvert-Jones 2 A/Professor David Thorburn, Professor Andrew Sinclair and the Honourable Tony Abbott MP 3 Janet and John Calvert-Jones with Dame Elisabeth Murdoch
Cruden farm family day
The second annual family fun day held at Dame Elisabeth Murdoch’s Cruden Farm was a great success with 2000 parents and children attending to raise $70,000. Thanks to our major sponsors the Herald Sun, Leader Community Newspapers, Aromababy and Country Road. We also received significant pro bono support from Circus Oz who provided the entertainment on the day. Thank you also to the organising committee, led by Susannah Calvert-Jones and all our wonderful volunteers.
Organising committee: Romy Bursztyn, Susannah Calvert-Jones, Narelle Curtis, Aimee Dean Pritchard, Gwenda Hance, Danni Hosking, Victoria Lord, Fraser Macvean, Lara Reynolds, Julia Rockman.
1 Dorothy the Dinosaur with Krissy and Rupert Clemenger 2 Charlotte and Isabella Taylor at the Country Road stall 3 Western bulldogs footballers Allan Toovey, Daniel Nicholls and Shannon Cox with Thomas, Callan and Joel 4 Angus Reynolds, David Gillespie, Antony Catalano, Allan Curtis 5 Josh, Tim, Romy and Ellie Burzstyn 6 Mime clown with Britney Percel
MCRI continued its three year involvement with The Age Portsea Polo Charity Cup, as the appointed charity of the exclusive player’s marquee hosted by Australia’s top player Ruki Baillieu, which raised $7000 for MCRI.
More than 300 people attended MCRI’s annual general meeting in May. CSIRO chairman Catherine Livingstone gave an informative talk on Australian research and development and MCRI director Professor Terry Dwyer outlined the institute’s research successes for the year.
1 Marita and Anthony McIntosh and Sarah Freeman 2 Hamish Cole and Amelia Coote 3 The winning Lexus polo team: Will Burrell, Gill and Hamish McLachlan, and Ruki Baillieu 4 The onfield action, the polo teams from Lexus and Country Road 5 Angus Reynolds and Cheralyn Price 6 John Calvert Jones with Prue McLeod and Rowly Paterson 7 Ilhan Foundation CEO Mary Benson with Dr Katie Allen
The first annual charity golf day for MCRI was marketed primarily to corporate organisations, as part of strategic efforts to increase fundraising income from this sector. More than $17,000 was raised and the event was very well received by the 60 attending golfers. Thanks to Dale St George and his team at The Heritage Golf & Country Club, and Jane Fenton and the team at Fenton Communications who planned and organised the day.
1 Our charity golf day team 2 Kristie Newton 3 Tim and Jane Derham with Barry Reardon and David Martin 4 Jamie Spry, Kristie Newton, Anthony McIntosh and Warwick Brown 5 Heath Jones, Darren Berry, Daniel Harford and Dale St George 6 Peter and Marilyn Bartels with Sandra and Bob Brannell 7 Jamie Spry 8 Ben Potter 9 Andrew Morley 10 Melissa Rothfield, Geoff Stansen, Suwanee Dharmal-Ingam and Ion Teska
The Puma Lap challenge saw 1200 corporate staff from 60 organisations competing in a 10 hour treadmill challenge to run as many 100 metre laps as possible. Participants were sponsored by their friends, family and colleagues to raise $430,000 for MCRI.
Sarah Murdoch launched the CEO challenge in Sydney, which saw corporate executives running on treadmills in Martin Place. The Melbourne CEO challenge was launched by Foxtel’s Mike Hammond and Sophie Falkiner and police chief Christine Nixon.
The team from Hicksons Lawyers won the award for running the most laps in Sydney, with the team from Salesforce victorious in Melbourne. By raising $19,738, the Clayton Utz team raised the most funds in Sydney, whilst the team from KordaMentha in Melbourne raised an incredible $26,000.
Thanks to PUMA, Nab, Foxtel, Eclipse, Get a life and The Australian Human Resources Institute.
1 Sarah Murdoch launches the Puma Lap challenge in Sydney 2 Mike Hammond and Sophie Falkiner with police chief Christine Nixon 3 AFL players Luke Hodge and Mark Coughlan 4 The team from HBOS with Sarah Murdoch 5 The winning team from Melbourne, Salesforce 6 The Melbourne CEO challenge
Thank you to all our generous donors, sponsors and event supporters in 2006.
ATony Aarons
Abercromby’s Real Estate
ABN AMRO
Paul Adams
Elizabeth Adler
AIG Australasia
Amanda Atkins
Alexander Robertson & Co
Tara Allan
JL Allanby
Alex Allegos
David Amor
Sofia Anagnostou
Peter Anderson
Jasmine Andrew
ANZ Client & Relationship Group & Private Bank
AON
Maria Aravantinos
Helen Archer
G M & C A Armour
Armoababy
Arnold Wittner Charitable Trust
Asian Pacific Building Corporation
Association of Greek & Affiliated
Panhellenic Interests
Diane Atkins
Toni Atkins
Australian Medical Insurance Limited
Axum International Trading
B
Lawrence & Davina Baillieu
Agnes Bankier
Baracon Group
Luigi & Iole Barbieri
Elli Bardas
Peter Barker
Sally Barnett
WH John Barr
Peter & Marilyn Bartels
Harry Barrass
Ken Barry
Sharon Bassat
MC Becke
Judy Begg
Katherine Behrend
Bell Charitable Fund
Bendigo Fire Station
Bendigo Truss Plant
Sandy Benjamin
John Bennie
Mary Benvenuto
Ross Betts
Bexton Personnel
Mrs & Mrs Billson
John & Dorothy Bines
Peter Bird & Cherie Zannette
CWD Blandy
Kate Boundy
Bowden Farm
Elaine Brennan
Bridge Real Estate
Carole Briggs
James Briggs
Kemal Brick
L Brokensha & S Hunt
Virginia Brook
Errol C Broome
Paul Brotchie
Nick & Prue Brown
RJ & IT Brown
David Brown
C Bull
Meredith Bunn
Eileen Burder
Timothy Burke
Michael Burn
Tim & Romy Bursztyn
David Burt
Anna Butler
Glen Butler
Michelle Butler
Rex Buzwell
CCafé Estella Pty Ltd
The Calvert-Jones Foundation
James & Susannah Calvert-Jones
John & Janet Calvert-Jones
Camec
Gary Cameron
Cecile Campbell
Canterbury Partners
Joseph Carbone
S Carolyn & H Kay
Brandon & Nicky Carp
Barry & Suzi Carp
B Carr
Clare Castell
Charities Aid Foundation
CHE / OMD
Dennis L Cheong
Wilson & Winnie Chong
Arthur Chong
Stella Clark
Clayton Utz
M Coates
Coca Cola
Cochrane-Scholfield Charitable Fund
Eyal Cohen
B & T Cohen
Charlotte Cole
Colliers International
Emma Cooper
Samantha Cooper
Philip & Caroline Cornish
Don Coulthard
Country Road
Cecily R Cox
Laura Cozzi
Kammeron Crea
Anne Cronin
Nicholas Crook
D Cullen
E M Cunningham
Rosanne Cunningham
Elizabeth Cunningham
Lorraine & Allan Curtis
Narelle Curtis
Cyprus Club Karavas Lambousa
Cyprus Community of Melbourne & Victoria
D
Deborah Damman
June Danks
Jane Darmon
Steve Davidson
DBR Corporation
Richard & Sarah de Crespigny
Miranda de La Masse-Homsy
Nigel Dearing
Martin Delatycki
Deloitte
Deloitte Foundation
Kate Dema
Lisa Dempsey
Katharine Derham-Moore
DesignInc Melbourne
Simon Dethridge
Nicole Dews
Diamond Valley & Eltham Kindergarten
Teachers Association
Dim Furniture
Sue Dixon
Michael Dowling
Desiree Du Sart
Thomas Duggan
Sandy Dupuis
E
Megan Edleston
Eclipse
Ekas Marketing Research Services
Andrew Eliadees
Elumina
Embelton Limited
Ernst & Young
Jennifer Esam
FPeter & Mary Fama
Deidre Farfor
Allan Fels
Fenton Communications
Carmel Ferretti
Alan Finney
Ann Fitzsimmons
The Flew Foundation
Foenix Ansett Group
FOXTEL
Elizabeth Fraser
Cameron Frewer
Friedreich Ataxia Research Association
Aaron Froling
GVelta Galens
Pamela Gali
Gandean
Neilma Ganter
Bruce Garratt
Libby Gellert
Sylvia Gelman
George Castan Family Charitable Foundation
Renos & Con Georgiou
Irene Giakoumis
Kerry Gillespie
S & M Gooley
Vivienne Gorman
Con & Genny Goulas
Louise Gourlay
Gourlay Charitable Trust
Antony Grage
Hugh Graham
Jamie & Rebecca Gray
Rebecca Gray
Rosemary Griffith
H
Michael Haintz
Maurice Hall
Reg Hall
BM Hall
Tom Hall
Pam Halligan
FJ & ER Ham
B J Hamilton
Susan Hamson
Addie Lee Hance
Peter Hardy-Smith
Judith Harley
Colin Harris
BC & AM Hartzer
Nicholas Hawkins
Brian Hay
Nan Haydon
Sam Hayes
Hayman Design
Barbara Haynes
Anne Hayward
HBOS
HBOS Australia Foundation
Heartkids New South Wales
HeartKids Queensland
Geoffrey Heeley
Peta Heffernan
Brian Hendy
B Henly
The Herald & Weekly Times
Heritage Golf & Country Club
Hicksons Laywers
Barbara Higgins
Hartley Higgins
DM & EP Hocking
Michael Hodder
WH Hodgson
James Hogan
KM & MJV Hoggard
Tanya Hollis
Marcus Holloway
Georgina Hope
Katrina Hope
Peter Howard
Victoria Howard
Howarth
The Hugh Williamson Foundation
Leanne Hughson
SEK Hulme
Michelle Hunt
Huraya
The Ilhan Foundation
Stevan Ilic
Independent Living Centre
Investec Bank Limited
Karina James
Michael James
Margaret James
Ben & Ros James
Kirsty Jamieson
Chrissie Japp
His Excellency Major General Michael
Jeffery
Jellis Craig
The Jenour Foundation
Shareen Joel
Fran Johnson
K
Kambos Community of Australia
Eleanor Kappelle
A Karanicolas
Veronica Kavanagh
Kay & Burton
Peter Kent
Kilwinning Nominees
Rob Kimoski
James Kimpton
Sheila Kimpton
Adrian King
Lorelle King
John & Heather King
Kirsty King
Mary Kipouropoulos
Barbara Knott
David Kolieb
KordaMentha
Michael Koutrouzas
KPMG
Kwik Kopy
Tony Kyriacou
L
Georgie La Fontaine
Nick Lanaras
JM Landy
Andrew Lane
Con & Nicole Lappas
Tim Laragy
IR Lawrence
Leader Community Newspapers
Gillie Learmonth
Fran Lefroy
GA & FJ Lefroy
Jean Lefroy
Joan Lefroy
Marj Lefory
Maxwell Lefroy
N Lefroy
G Leggo
Kristine Lempriere
Marie Lerigo
J B Leslie
Leonard Levy
Elizabeth Lewis
QiaoXin Li
George & Janet Limb
Lions Club of Clarinda
Elizabeth Lithgow
Brian Little
Anthony Loschiavo
Tom Lowenstein
Peter Lynch M
Janet Macdonald
Dame Patricia Mackinnon
Andrew MacLachlan
Alisdair MacLeod
Hamish Macmillan
Macquarie Bank Foundation
Macquarie Bank Limited
Fraser & Annika Macvean
Anthony Macvean
Julie Madison
Sue Magee
Elizabeth Mair
Jack Mangan
Joshua Mantello
Adrian Marchesani
Denis Margetic
Daniela Mariani
Vas Maroulis
Peter R Marriott
Tony Marsh
Elizabeth Marshall
Marshall White
Paul Mather
Sotiris Matis
Althea Maxwell
Ian McAlister
David McCallum
E J McDonald
C A McDonald
Anthony McIntosh
Douglas Meagher
Melbourne Community Fund
Ann Michod
The Miller Foundation
Michael Minski
Minter Ellison
Dean Mohr
Anthony Monea
Rosemary Monotti
Sir Mark Moody
Dr Spiros Moraitis
Suzanne Morgan
Hugh M Morgan
Marie Morton
Jacinta Munro
Ashley Murdoch
Dame Elisabeth Murdoch AC DBE
M Murray
Sabrina Murray
Myer Foundation
N Nab
Nab Private Bank
Naousa Club
Nationwide News
Stuart Nelson
C Neophitou
Phito Neophitou
Chris Nicholas
John Nickson
Andreas & Panayiota Nicolaou
Carolyn Nikakis
Helen Noble
Nordia Foundation
North East Newspapers
O
Susan O’Brien
Michelle O’Brien
Anthea O’Connor
Ogilivy Healthworld
Fred & Martine Oldfield
Dawn Osborne
Michael Osborne
Kevin O’Sullivan
P
Andrew Papp
Ben Patterson
Sam Patterson
Raymond Paul
Cameron Perkins
Peter Isaacson Foundation
Justin Peters
Paul Peterson
Dr D J Pittard
PKF
Mark Podgornik
Karen Pollock
Michael Porter
Sally Porter
Georgegina Poulos
J & E Powell
Robert Pratt
The Pratt Foundation
Karen Price
Proteus Research Dinner
Ronda Puckey
PUMA
Q
Adrian Quilter
R
Shelley Racine
Brendan Redden
Sheena Reilly
Garry Reynolds
Angus & Lara Reynolds
Jenny Ridgway
S Riggall & NJ Lefroy
Sam Riggall
H Riggall
Emma Ritchie’s Trust Fund
River Capital
June Roberts
Annette Roberts
The Rotary Club of Keilor
Dr & Mrs Robinson
B J Roper
Sandra Rosen
Paul & Gay Rosen
Jeremy Rosenbaum
Rosemary Ross
Ross Human Directions
AS Partners
Annette Rowe
Peter Rowsthorn
Adele Rushton
Russell Investment Group
Simone Ryan
S Sally Sadler
SADS Foundation
M Sahhar
SAI Private Investments
SalesForce
John Salmons
Raoul Salter
Dennis Sams
S Sarkar
Heather Saunders
Ros Savas
Peter Scales
Adelaide Scarborough
Cameron W Scharl
Julian Schiller
Katrin Schneider
Caroline Scully
Servcorp
W Seward
Jeremy Shapiro
Paul Sheahan
A & J Sheats
Frank & Ann Shelton
Kim Shepherd
M L Sims
Seelan J Singham
Gail Siracusa
Karin Sitte-Meagher
D E Slack
Stephen Smith
Annette Smorgon
Amanda Smorgon
Ian Soloman
Betty Sommerville
Mary Spanos
Neil Spitzer
Nicole Spore
Sportsco
St George Bank Limited
St Thomas’ Ladies Guild
Margarete Steffens
Ninian & Valery Stephen
Valery Stephen
FD Stephens
Grant R Stephenson
M Stewart
Hayden Stockdale
Tammy Stokie
Simon Stuart
Suncorp
Richard Sutcliffe
R Sutton
IA Swain
The Swann Group
Robin Syme T
Jillian Tacon
Andrew Tauro
Matthew Taylor
Templestowe Valley Primary School
E Templeton
Telstra
Kevin Teoh
TeskaCarson
Susan Thacore
Thalassaemia Association of Western
Australia
Thalassaemia Society of South Australia
Thalassaemia Society of Victoria
Thalsassaemia Society of New South Wales
Theo Metal Polishers
The Theresa Byrnes Foundation
Anthony Thomas
Peter & Debbie
Thomas
Mark Thompson
Tialon
Tim & Terry Oyster Supply
Alison Tough U
Uncle Bob’s Club V
Jim Vadolas
Maria Vamvakinou
Variety the Childrens Charity
Leonard S Vary
John Vaughan
Jasmin Vergins
The Victor Smorgon Charitable Foundation
Victorian Preceptor Psi Chapter
Victorian Transport Association
Georgie Vile
Village Roadshow
Vintage Cellars
M & D Vukadinovic
W
Colin Walker
Nick Ward & Anna Lee
Timothy Ward
C & R Watkins
J D Watson
Andrea Watson
Wealth Solutions Australia
Jenny Webb
Westbury Office Supplies
Patrick Western
Wheatgrass
H Wheelahan
Donna White
Bill White
Ursula Whiteside
The William Angliss Charitable Fund
William Buck
The William Burrell Charitable Trust
Bob Williamson
M & P Wong
Billie & Sue Wood
Michael Yates
ER Yencken
Leonard & Doreen Yong
Lukas Zdanius
Ferial Zakiman
Oren Zohar
Estates
Estate of NE Creaton
Estate of Ursula May Frawley
Estate of Gladys Mabel Morton
Estate of L I Roach
Estate of Agnes Tait Robertson
Estate of Joan Roxburgh
Estate of Daisy Violet Waller
In lieu of gifts for Helen Carp’s birthday
Barry & Lorraine Bloom
Norman & Pauline Bloom
Stephen & Betty Briggs
Mr & Mrs Joe & Pam Bursztyn
Michael & Carol Casper
Colin & Debbie Edwards
Barry & Kaye Fink
Joe & Glenda Flinkier
John & Jenny Fox (Foxworth)
Leigh & Yvonne Goldbloom
Robert & Pauline Grodski
David & Rhonda Jacobson
Mr & Mrs Morris & Leonie Joel
Mel & Judi Korman
Mr & Mrs Lionel & Marian Krongold
Bori & Helen Liberman
Jeffrey & Helen Mahemoff
David & Roslyn Smorgon
Ms Lynn Trayer
Morry & Pauline Wrobel
In honour of the 70th Birthday of
Mrs Noga Shub
Micheline Adorjan
P & M Bancroft
Rosetta Baron
D Gibgot
C & E Goldberg
RG & MR Goldsmith
R J Hall
Janet Isaacs
Ivanoff Nominees
David & Audrey Johnstone
I & A Kiven
R Levy
M010225
R A Marshall
JL Moffatt
JM Mylius
Reuben & Delysia Pahoff
D Porritt
J & A Rose
Helena Rymer
Bennie Schreiber
A Segal
Viko Industries Australia
In lieu of Christmas gifts for the
Curtis family
John Halligan
In lieu of Christmas gifts for the Mackay family
Jenny Shelmerdine
In lieu of corporate Christmas cards
Beaton Consulting
Fenton Communications
In memory of David Bland
ARA Electrical Services
Louise Bland
The Bowe Family
Elizabeth Brookes
Catherine Cabena
Gail Cockram
Catherine Franklin-Hensler
Cathie Harle
Edith Harris
Ophelia Leviny
Melbourne Grammar School
Melbourne Grammar School - Wadhurst
Drama
Rupert Le Messurier
Angela Mosca
Maxine O’Neill
Lorna Parke
Nehama Patkin
Sue Peden
Bill, Jen, Beth, David & Ann Pretty
Andrew Sheahan
Sue Sweeney
Elly Symons
Grant & Sue Taylor
Timberwolves Basketball Club
Miriam Toussant
Victorian Music Teachers’ Association
Jenny Waterston
Mary Young
In memory of Suzanne Brown
Jack & Irene Brown
In memory of William Brown
Mr & Mrs Harries
In memory of Shaun Nicholas
Martin
Bonnie & Steve Redman
Ken & Irene Redman
In memory of Indiana Jasmine
Orlando
Brian, Sarah & Emma Hanly
J Warlow
In memory of Indiana Orlando and William Tudhope
Judith Gardner
In memory of Matthew Paikos
Arthur & Heather Paikos
Maria Paikos
In memory of Emma Ritchie
Robyna Calisthenic College
In memory of Sam Ryder
Bridge Real Estate P/L
In memory of William B Tudhope
Townsville Golf Club (Tuesday morning
ladies)
Rosslyn & Robert Murray
P & W Nannini
Event sponsors
Abercromby’s Real Estate
Armoababy
Coca Cola
Country Road
Deloitte
Eclipse
Elumina
Fenton Communications
FOXTEL
The Herald & Weekly Times
Heritage Golf & Country Club
KPMG
Kwik Kopy
Leader Community Newspapers
Nab
PUMA
Sportsco
Vintage Cellars
The PUMA Lap participating teams
ABN AMRO
ANZ Client & Relationship Group & Private
Bank
AON
Australian Medical Insurance Limited
CHE / OMD
Clayton Utz
Colliers International
Deloitte
Eclipse
Ernst & Young
FOXTEL
HBOS
Hicksons Laywers
Howarth
Investec Bank Limited
KordaMentha
KPMG
Nab Private Bank
Nab
Macquarie Bank Limited
Minter Ellison
PKF
PUMA
River Capital
Ross Human Directions
Russell Investment Group
SAI
SalesForce
Servcorp
St George Bank Limited
Suncorp
Telstra
William Buck
Heritage Charity Golf Day
participating teams
ABN AMRO
Abercromby’s Real Estate
Peter & Marilyn Bartels
Canterbury Parnters
Elumina
Fenton Communications
Anthony McIntosh
KPMG
Kwik Kopy
Sportsco
TeskaCarson
Major pro bono supporters
The Age
Austereo Network
Decons lawyers
Elite Fitness Equipment
Eclipse
Fenton Communications
John & Agita Haddad
Herald Sun
Hub Group
Inlink Media
KPMG
Macquarie Bank Limited
News Custom Publishing
News Limited
Qantas
River Capital
Splitrock
Sweeney Research
Tara Press
Village Roadshow Limited
Event supporters (pro bono)
Adairs
Aussie Bodies Health Bars
Australia Post
Bib Stillwell BMW
Bliss Models
Bump to 3
Cadbury Schweppes
Café Racer
Calibre
Carter Humphries
Cate Boots
Channel 9
Cheviot Bridge
Chino Kids
Circus Oz
Collingwood Football Club
CPL Services
Creative Balloon Company
Creative Brands
Dominique Horne
Elite Health
Sophie Falkiner
FPC Australian Parents Magazine
Fosters
Fruit Only
Get a Life
Great Golf Events
Greentix
Gwenda Hance
Mike Hammond
Healthbrands Australia
Inspired Living
Kittee Accessories
Kormico Soft Toys
kounia-bella
Asher Kuerten
Marcus B
Marshall White
Melbourne Victory
Mercedes Waratah Press
MILO
Mobile Playgrounds
Music Theatre Australia
Nestle
Noah’s Aeroplane
Octopus Promotions
Passionfoods
Patrick Jones Photographic Studio
Peninsula Horse & Cart Rides
Phillipa’s
Pizza at Home
Prestige lip gloss
Rubyteva
Scanlon & Theodore
SDP Photo
Seed
Slim Secrets
Smiggle
Smudge
SPC Ardmona
Sportsgirl
The Council
The Sebel Heritage, Yarra Valley
The Wiggles
Tiffany Cherry
Town Mouse
TTFM
Vango Coffee
Vintage Cellars
Western Bulldogs Football Club
Windsor Farm Foods
Thanks to the following organisations who generously assisted in the production of this report.
Design
News Custom Publishing
Printing Southern Colour
Paper stock Paperlinx
Edited by Dr Narelle Curtis, Alyssa Jones & Tiffyn Smillie (pr@mcri.edu.au)
Cover photograph Getty Images
Murdoch Childrens Research Institute
Royal Children’s Hospital
Flemington Road, Parkville
Phone:
www.mcri.edu.au